-- dump date 20140620_065109 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_401729.1 82775383 3799883 190..255 1 NC_007606.1 thr operon leader peptide 255 thrL 3799883 thrL Shigella dysenteriae Sd197 thr operon leader peptide YP_401729.1 190 D 300267 CDS YP_401730.1 82775384 3796040 336..2798 1 NC_007606.1 homoserine dehydrogenase I; multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2798 thrA 3796040 thrA Shigella dysenteriae Sd197 bifunctional aspartokinase I/homoserine dehydrogenase I YP_401730.1 336 D 300267 CDS YP_401731.1 82775385 3796041 2800..3732 1 NC_007606.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3732 thrB 3796041 thrB Shigella dysenteriae Sd197 homoserine kinase YP_401731.1 2800 D 300267 CDS YP_401732.1 82775386 3796042 3733..5019 1 NC_007606.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5019 thrC 3796042 thrC Shigella dysenteriae Sd197 threonine synthase YP_401732.1 3733 D 300267 CDS YP_401733.1 82775387 3796043 5233..5529 1 NC_007606.1 hypothetical protein 5529 3796043 SDY_0005 Shigella dysenteriae Sd197 hypothetical protein YP_401733.1 5233 D 300267 CDS YP_401734.1 82775388 3796044 complement(5682..6458) 1 NC_007606.1 Code: S; COG: COG3022; hypothetical protein 6458 yaaA 3796044 yaaA Shigella dysenteriae Sd197 hypothetical protein YP_401734.1 5682 R 300267 CDS YP_401736.1 82775390 3796046 8230..9183 1 NC_007606.1 Code: G; COG: COG0176; transaldolase B 9183 talB 3796046 talB Shigella dysenteriae Sd197 transaldolase B YP_401736.1 8230 D 300267 CDS YP_401737.1 82775391 3796047 9298..9885 1 NC_007606.1 required for the efficient incorporation of molybdate into molybdoproteins; forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein 9885 mogA 3796047 mogA Shigella dysenteriae Sd197 molybdenum cofactor biosynthesis protein YP_401737.1 9298 D 300267 CDS YP_401738.1 82775392 3796048 complement(9920..10486) 1 NC_007606.1 Code: S; COG: COG1584; hypothetical protein 10486 yaaH 3796048 yaaH Shigella dysenteriae Sd197 hypothetical protein YP_401738.1 9920 R 300267 CDS YP_401739.1 82775393 3796049 complement(10635..11348) 1 NC_007606.1 Code: S; COG: COG4735; hypothetical protein 11348 3796049 SDY_0011 Shigella dysenteriae Sd197 hypothetical protein YP_401739.1 10635 R 300267 CDS YP_401740.1 82775394 3796050 complement(11374..11733) 1 NC_007606.1 hypothetical protein 11733 yaaI 3796050 yaaI Shigella dysenteriae Sd197 hypothetical protein YP_401740.1 11374 R 300267 CDS YP_401741.1 82775395 3796051 12155..14071 1 NC_007606.1 DNA biosynthesis; autoregulated heat shock proteins; heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14071 dnaK 3796051 dnaK Shigella dysenteriae Sd197 molecular chaperone DnaK YP_401741.1 12155 D 300267 CDS YP_401742.1 82775396 3796052 14160..15290 1 NC_007606.1 chaperone with DnaK; ''chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion''; molecular chaperone DnaJ 15290 dnaJ 3796052 dnaJ Shigella dysenteriae Sd197 molecular chaperone DnaJ YP_401742.1 14160 D 300267 CDS YP_401743.1 82775397 3796053 complement(15394..15603) 1 NC_007606.1 interferes with membrane function when in excess; Gef protein 15603 gef 3796053 gef Shigella dysenteriae Sd197 Gef protein YP_401743.1 15394 R 300267 CDS YP_009000618.1 578793077 18262935 complement(16286..16558) 1 NC_007606.1 insertion element iso-IS1N protein InsA 16558 18262935 SDY_0017a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000618.1 16286 R 300267 CDS YP_401746.1 82775400 3796056 16905..18071 1 NC_007606.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 18071 nhaA 3796056 nhaA Shigella dysenteriae Sd197 pH-dependent sodium/proton antiporter YP_401746.1 16905 D 300267 CDS YP_401747.1 82775401 3796057 18131..19036 1 NC_007606.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 19036 nhaR 3796057 nhaR Shigella dysenteriae Sd197 transcriptional activator NhaR YP_401747.1 18131 D 300267 CDS YP_401748.1 82775402 3796058 complement(19074..19601) 1 NC_007606.1 hypothetical protein 19601 3796058 SDY_0020 Shigella dysenteriae Sd197 hypothetical protein YP_401748.1 19074 R 300267 CDS YP_009000619.1 578793078 18262936 19712..19984 1 NC_007606.1 insertion element iso-IS1N protein InsA 19984 18262936 SDY_0022a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000619.1 19712 D 300267 CDS YP_401750.1 82775404 3797315 20011..20406 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 20406 3797315 SDY_0022 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_401750.1 20011 D 300267 CDS YP_401751.1 82775405 3797316 complement(20512..20889) 1 NC_007606.1 Code: L; COG: COG1662; insertion sequence element IS1 transposase 20889 insB 3797316 insB Shigella dysenteriae Sd197 insertion sequence element IS1 transposase YP_401751.1 20512 R 300267 CDS YP_401752.1 82775406 3797317 complement(20934..21209) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 21209 insA 3797317 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401752.1 20934 R 300267 CDS YP_401753.1 82775407 3797318 21788..24385 1 NC_007606.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 24385 acnB 3797318 acnB Shigella dysenteriae Sd197 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_401753.1 21788 D 300267 CDS YP_401754.2 161950172 3797319 24560..24922 1 NC_007606.1 Code: S; COG: COG3112; hypothetical protein 24922 yacL 3797319 yacL Shigella dysenteriae Sd197 hypothetical protein YP_401754.2 24560 D 300267 CDS YP_401755.1 82775409 3797320 complement(24960..25754) 1 NC_007606.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 25754 speD 3797320 speD Shigella dysenteriae Sd197 S-adenosylmethionine decarboxylase YP_401755.1 24960 R 300267 CDS YP_401756.1 82775410 3797321 complement(25770..26636) 1 NC_007606.1 putrescine aminopropyltransferase; catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 26636 speE 3797321 speE Shigella dysenteriae Sd197 spermidine synthase YP_401756.1 25770 R 300267 CDS YP_401758.1 82775412 3797323 27255..28805 1 NC_007606.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 28805 yacK 3797323 yacK Shigella dysenteriae Sd197 multicopper oxidase YP_401758.1 27255 D 300267 CDS YP_401759.1 82779654 3797324 29799..30074 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 30074 insA 3797324 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401759.1 29799 D 300267 CDS YP_401760.1 82775413 3797325 30119..30496 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 30496 insB 3797325 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401760.1 30119 D 300267 CDS YP_401761.2 161950171 3797327 32224..32760 1 NC_007606.1 Code: F; COG: COG0634; hypoxanthine phosphoribosyltransferase 32760 hpt 3797327 hpt Shigella dysenteriae Sd197 hypoxanthine phosphoribosyltransferase YP_401761.2 32224 D 300267 CDS YP_401762.1 82775415 3797328 complement(32801..33463) 1 NC_007606.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 33463 yadF 3797328 yadF Shigella dysenteriae Sd197 carbonic anhydrase YP_401762.1 32801 R 300267 CDS YP_401763.1 82775416 3797329 33572..34498 1 NC_007606.1 Code: V; COG: COG1131; ATPase 34498 yadG 3797329 yadG Shigella dysenteriae Sd197 ATPase YP_401763.1 33572 D 300267 CDS YP_401764.1 82775417 3797330 34495..35265 1 NC_007606.1 Code: V; COG: COG0842; hypothetical protein 35265 yadH 3797330 yadH Shigella dysenteriae Sd197 hypothetical protein YP_401764.1 34495 D 300267 CDS YP_401765.1 82775418 3797331 35370..35810 1 NC_007606.1 Code: G; COG: COG2893; PTS system transporter subunit IIB 35810 yadI 3797331 yadI Shigella dysenteriae Sd197 PTS system transporter subunit IIB YP_401765.1 35370 D 300267 CDS YP_401768.1 82775421 3799806 complement(37108..37488) 1 NC_007606.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 37488 panD 3799806 panD Shigella dysenteriae Sd197 aspartate alpha-decarboxylase YP_401768.1 37108 R 300267 CDS YP_401769.1 82775422 3799807 37762..38562 1 NC_007606.1 Code: S; COG: COG5464; hypothetical protein 38562 yadD 3799807 yadD Shigella dysenteriae Sd197 hypothetical protein YP_401769.1 37762 D 300267 CDS YP_401770.1 82775423 3799808 38591..38866 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 38866 insA 3799808 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401770.1 38591 D 300267 CDS YP_401771.1 82775424 3799809 38911..39288 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 39288 insB 3799809 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401771.1 38911 D 300267 CDS YP_401772.1 82775425 3799810 complement(39604..39867) 1 NC_007606.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 39867 rpsT 3799810 rpsT Shigella dysenteriae Sd197 30S ribosomal protein S20 YP_401772.1 39604 R 300267 CDS YP_401773.1 82775426 3799811 39970..40188 1 NC_007606.1 hypothetical protein 40188 3799811 SDY_0046 Shigella dysenteriae Sd197 hypothetical protein YP_401773.1 39970 D 300267 CDS YP_401774.1 82775427 3799812 40196..41137 1 NC_007606.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 41137 ribF 3799812 ribF Shigella dysenteriae Sd197 bifunctional riboflavin kinase/FMN adenylyltransferase YP_401774.1 40196 D 300267 CDS YP_401775.1 82775428 3799813 41180..43996 1 NC_007606.1 ''IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme''; isoleucyl-tRNA synthetase 43996 ileS 3799813 ileS Shigella dysenteriae Sd197 isoleucyl-tRNA synthetase YP_401775.1 41180 D 300267 CDS YP_401776.1 82775429 3799814 43996..44490 1 NC_007606.1 SPase II; lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 44490 lspA 3799814 lspA Shigella dysenteriae Sd197 lipoprotein signal peptidase YP_401776.1 43996 D 300267 CDS YP_401777.1 82775430 3799815 44578..45027 1 NC_007606.1 rotamase; Code: O; COG: COG1047; FKBP-type peptidylprolyl isomerase 45027 slpA 3799815 slpA Shigella dysenteriae Sd197 FKBP-type peptidylprolyl isomerase YP_401777.1 44578 D 300267 CDS YP_401778.1 82775431 3799816 45029..45979 1 NC_007606.1 involved in penicillin tolerance; catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 45979 ispH 3799816 ispH Shigella dysenteriae Sd197 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_401778.1 45029 D 300267 CDS YP_401779.1 82775432 3799817 46045..46959 1 NC_007606.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 46959 yaaF 3799817 yaaF Shigella dysenteriae Sd197 ribonucleoside hydrolase RihC YP_401779.1 46045 D 300267 CDS YP_401780.1 82775433 3799818 47126..47947 1 NC_007606.1 ''catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis''; dihydrodipicolinate reductase 47947 dapB 3799818 dapB Shigella dysenteriae Sd197 dihydrodipicolinate reductase YP_401780.1 47126 D 300267 CDS YP_401781.1 82775434 3799819 48405..49553 1 NC_007606.1 small subunit; catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 49553 carA 3799819 carA Shigella dysenteriae Sd197 carbamoyl phosphate synthase small subunit YP_401781.1 48405 D 300267 CDS YP_401782.1 82775435 3799820 49571..52792 1 NC_007606.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 52792 carB 3799820 carB Shigella dysenteriae Sd197 carbamoyl phosphate synthase large subunit YP_401782.1 49571 D 300267 CDS YP_401784.1 82775437 3799822 complement(53534..54145) 1 NC_007606.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 54145 caiE 3799822 caiE Shigella dysenteriae Sd197 carnitine operon protein CaiE YP_401784.1 53534 R 300267 CDS YP_401785.1 82775438 3799823 complement(54130..55023) 1 NC_007606.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 55023 caiD 3799823 caiD Shigella dysenteriae Sd197 carnitinyl-CoA dehydratase YP_401785.1 54130 R 300267 CDS YP_401786.1 82775439 3799824 complement(55024..56592) 1 NC_007606.1 Code: IQ; COG: COG0318; crotonobetaine/carnitine-CoA ligase 56592 caiC 3799824 caiC Shigella dysenteriae Sd197 crotonobetaine/carnitine-CoA ligase YP_401786.1 55024 R 300267 CDS YP_401787.1 82775440 3798940 complement(56651..57868) 1 NC_007606.1 ''catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine''; crotonobetainyl-CoA:carnitine CoA-transferase 57868 caiB 3798940 caiB Shigella dysenteriae Sd197 crotonobetainyl-CoA:carnitine CoA-transferase YP_401787.1 56651 R 300267 CDS YP_401788.1 82775441 3798941 complement(57997..59139) 1 NC_007606.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 59139 caiA 3798941 caiA Shigella dysenteriae Sd197 crotonobetainyl-CoA dehydrogenase YP_401788.1 57997 R 300267 CDS YP_401789.1 82775442 3798942 complement(59170..60684) 1 NC_007606.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 60684 caiT 3798942 caiT Shigella dysenteriae Sd197 L-carnitine/gamma-butyrobetaine antiporter YP_401789.1 59170 R 300267 CDS YP_401790.2 161950169 3798943 61156..61926 1 NC_007606.1 probable flavoprotein subunit; carnitine metabolism; ''required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase''; electron transfer flavoprotein FixA 61926 fixA 3798943 fixA Shigella dysenteriae Sd197 electron transfer flavoprotein FixA YP_401790.2 61156 D 300267 CDS YP_401791.1 82775444 3798944 61941..62882 1 NC_007606.1 probable flavoprotein subunit; carnitine metabolism; involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 62882 fixB 3798944 fixB Shigella dysenteriae Sd197 electron transfer flavoprotein FixB YP_401791.1 61941 D 300267 CDS YP_401793.1 82775446 3798946 64215..64502 1 NC_007606.1 Code: C; COG: COG2440; ferredoxin 64502 fixX 3798946 fixX Shigella dysenteriae Sd197 ferredoxin YP_401793.1 64215 D 300267 CDS YP_401796.1 82775449 3798949 66002..66532 1 NC_007606.1 ''Required for full activity of KefC, a potassium-proton antiporter''; glutathione-regulated potassium-efflux system ancillary protein KefF 66532 yabF 3798949 yabF Shigella dysenteriae Sd197 glutathione-regulated potassium-efflux system ancillary protein KefF YP_401796.1 66002 D 300267 CDS YP_401797.1 82775450 3798950 66525..68192 1 NC_007606.1 Code: P; COG: COG1226; K+ efflux antiporter, glutathione-regulated 68192 kefC 3798950 kefC Shigella dysenteriae Sd197 K+ efflux antiporter, glutathione-regulated YP_401797.1 66525 D 300267 CDS YP_401798.1 82775451 3798951 68384..68863 1 NC_007606.1 trimethoprim resistance; catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 68863 folA 3798951 folA Shigella dysenteriae Sd197 dihydrofolate reductase YP_401798.1 68384 D 300267 CDS YP_401799.1 82775452 3798952 68949..69182 1 NC_007606.1 Code: R; COG: COG5302; antitoxin of gyrase inhibiting toxin-antitoxin system 69182 3798952 SDY_0072 Shigella dysenteriae Sd197 antitoxin of gyrase inhibiting toxin-antitoxin system YP_401799.1 68949 D 300267 CDS YP_401800.1 82775453 3798953 69185..69499 1 NC_007606.1 toxin of gyrase inhibiting toxin-antitoxin system 69499 3798953 SDY_0073 Shigella dysenteriae Sd197 toxin of gyrase inhibiting toxin-antitoxin system YP_401800.1 69185 D 300267 CDS YP_401801.1 82775454 3798954 complement(69496..70344) 1 NC_007606.1 ''hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP''; diadenosine tetraphosphatase 70344 apaH 3798954 apaH Shigella dysenteriae Sd197 diadenosine tetraphosphatase YP_401801.1 69496 R 300267 CDS YP_401802.1 82775455 3798955 complement(70351..70728) 1 NC_007606.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 70728 apaG 3798955 apaG Shigella dysenteriae Sd197 ApaG protein YP_401802.1 70351 R 300267 CDS YP_401803.1 82775456 3798956 complement(70731..71552) 1 NC_007606.1 rRNA dimethyltransferase; catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 71552 ksgA 3798956 ksgA Shigella dysenteriae Sd197 dimethyladenosine transferase YP_401803.1 70731 R 300267 CDS YP_401804.1 82775457 3798957 complement(71549..72538) 1 NC_007606.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 72538 pdxA 3798957 pdxA Shigella dysenteriae Sd197 4-hydroxythreonine-4-phosphate dehydrogenase YP_401804.1 71549 R 300267 CDS YP_401805.1 82775458 3798958 complement(72538..73824) 1 NC_007606.1 ''Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB''; peptidyl-prolyl cis-trans isomerase SurA 73824 surA 3798958 surA Shigella dysenteriae Sd197 peptidyl-prolyl cis-trans isomerase SurA YP_401805.1 72538 R 300267 CDS YP_401806.1 82775459 3798959 complement(73877..76231) 1 NC_007606.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 76231 imp 3798959 imp Shigella dysenteriae Sd197 organic solvent tolerance protein YP_401806.1 73877 R 300267 CDS YP_401807.1 82775460 3799440 76486..77301 1 NC_007606.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 77301 djlA 3799440 djlA Shigella dysenteriae Sd197 Dna-J like membrane chaperone protein YP_401807.1 76486 D 300267 CDS YP_401808.1 82775461 3799441 77596..78312 1 NC_007606.1 hypothetical protein 78312 yabP 3799441 yabP Shigella dysenteriae Sd197 hypothetical protein YP_401808.1 77596 D 300267 CDS YP_401809.1 82775462 3799442 complement(78719..79378) 1 NC_007606.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 79378 yabO 3799442 yabO Shigella dysenteriae Sd197 23S rRNA/tRNA pseudouridine synthase A YP_401809.1 78719 R 300267 CDS YP_401810.1 82775463 3799443 complement(79390..82296) 1 NC_007606.1 ''transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA''; ATP-dependent helicase HepA 82296 hepA 3799443 hepA Shigella dysenteriae Sd197 ATP-dependent helicase HepA YP_401810.1 79390 R 300267 CDS YP_401811.1 82775464 3799444 complement(83937..84332) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 84332 3799444 SDY_0084 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_401811.1 83937 R 300267 CDS YP_009000620.1 578793079 18262937 complement(84359..84631) 1 NC_007606.1 insertion element iso-IS1N protein InsA 84631 18262937 SDY_0084a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000620.1 84359 R 300267 CDS YP_401812.1 82775465 3799445 85070..85345 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 85345 insA 3799445 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401812.1 85070 D 300267 CDS YP_401813.1 82775466 3799446 85390..85767 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 85767 insB 3799446 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401813.1 85390 D 300267 CDS YP_401814.1 82775467 3799448 complement(86437..87132) 1 NC_007606.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 87132 araD 3799448 araD Shigella dysenteriae Sd197 L-ribulose-5-phosphate 4-epimerase YP_401814.1 86437 R 300267 CDS YP_401815.1 82775468 3799449 complement(87300..88802) 1 NC_007606.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 88802 araA 3799449 araA Shigella dysenteriae Sd197 L-arabinose isomerase YP_401815.1 87300 R 300267 CDS YP_401816.1 82775469 3799450 complement(88813..90513) 1 NC_007606.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 90513 araB 3799450 araB Shigella dysenteriae Sd197 ribulokinase YP_401816.1 88813 R 300267 CDS YP_401817.1 82775470 3799452 91820..92584 1 NC_007606.1 Code: S; COG: COG0586; hypothetical protein 92584 yabI 3799452 yabI Shigella dysenteriae Sd197 hypothetical protein YP_401817.1 91820 D 300267 CDS YP_401818.1 82775471 3799453 complement(92698..93396) 1 NC_007606.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine ABC transporter ATP-binding protein 93396 thiQ 3799453 thiQ Shigella dysenteriae Sd197 thiamine ABC transporter ATP-binding protein YP_401818.1 92698 R 300267 CDS YP_401819.1 82775472 3799454 complement(93380..94990) 1 NC_007606.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine ABC transporter permease 94990 thiP 3799454 thiP Shigella dysenteriae Sd197 thiamine ABC transporter permease YP_401819.1 93380 R 300267 CDS YP_401820.1 82775473 3799455 complement(94966..95949) 1 NC_007606.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine ABC transporter substrate-binding protein 95949 tbpA 3799455 tbpA Shigella dysenteriae Sd197 thiamine ABC transporter substrate-binding protein YP_401820.1 94966 R 300267 CDS YP_401821.1 82775474 3799456 complement(96649..96924) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 96924 insA 3799456 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401821.1 96649 R 300267 CDS YP_401822.1 82775475 3799457 complement(97447..99105) 1 NC_007606.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 99105 yabN 3799457 yabN Shigella dysenteriae Sd197 transcriptional regulator SgrR YP_401822.1 97447 R 300267 CDS YP_401823.1 82775476 3799458 complement(99433..100038) 1 NC_007606.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 100038 leuD 3799458 leuD Shigella dysenteriae Sd197 isopropylmalate isomerase small subunit YP_401823.1 99433 R 300267 CDS YP_401824.1 82775477 3795905 complement(100049..101449) 1 NC_007606.1 dehydratase subunit; ''dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate''; isopropylmalate isomerase large subunit 101449 leuC 3795905 leuC Shigella dysenteriae Sd197 isopropylmalate isomerase large subunit YP_401824.1 100049 R 300267 CDS YP_401825.2 161950168 3795906 complement(101452..102543) 1 NC_007606.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 102543 leuB 3795906 leuB Shigella dysenteriae Sd197 3-isopropylmalate dehydrogenase YP_401825.2 101452 R 300267 CDS YP_401826.1 82775479 3795907 complement(102543..104114) 1 NC_007606.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 104114 leuA 3795907 leuA Shigella dysenteriae Sd197 2-isopropylmalate synthase YP_401826.1 102543 R 300267 CDS YP_401827.1 82775480 3795908 complement(104207..104290) 1 NC_007606.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 104290 leuL 3795908 leuL Shigella dysenteriae Sd197 leu operon leader peptide YP_401827.1 104207 R 300267 CDS YP_009000621.1 578793080 18262938 104462..104734 1 NC_007606.1 insertion element iso-IS1N protein InsA 104734 18262938 SDY_0102a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000621.1 104462 D 300267 CDS YP_009000622.1 578793081 3795911 complement(105404..105781) 1 NC_007606.1 insertion sequence element IS1 transposase 105781 insB 3795911 insB Shigella dysenteriae Sd197 insertion sequence element IS1 transposase YP_009000622.1 105404 R 300267 CDS YP_401830.1 82775483 3795912 complement(105826..106101) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 106101 insA 3795912 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_401830.1 105826 R 300267 CDS YP_401831.1 82775484 3795913 106283..108007 1 NC_007606.1 ''catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive''; acetolactate synthase 3 catalytic subunit 108007 ilvI 3795913 ilvI Shigella dysenteriae Sd197 acetolactate synthase 3 catalytic subunit YP_401831.1 106283 D 300267 CDS YP_401832.1 82775485 3795914 108010..108501 1 NC_007606.1 valine sensitive; ''with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit''; acetolactate synthase 3 regulatory subunit 108501 ilvH 3795914 ilvH Shigella dysenteriae Sd197 acetolactate synthase 3 regulatory subunit YP_401832.1 108010 D 300267 CDS YP_401834.1 82775487 3795916 108681..109685 1 NC_007606.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 109685 fruR 3795916 fruR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator FruR YP_401834.1 108681 D 300267 CDS YP_401835.1 82775488 3795917 110288..110746 1 NC_007606.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 110746 yabB 3795917 yabB Shigella dysenteriae Sd197 cell division protein MraZ YP_401835.1 110288 D 300267 CDS YP_401836.1 82775489 3795918 110748..111689 1 NC_007606.1 Code: M; COG: COG0275; S-adenosyl-methyltransferase MraW 111689 mraW 3795918 mraW Shigella dysenteriae Sd197 S-adenosyl-methyltransferase MraW YP_401836.1 110748 D 300267 CDS YP_401837.1 82775490 3795919 111686..112051 1 NC_007606.1 ingrowth of wall at septum; membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 112051 ftsL 3795919 ftsL Shigella dysenteriae Sd197 cell division protein FtsL YP_401837.1 111686 D 300267 CDS YP_401838.1 82775491 3795920 112067..113833 1 NC_007606.1 septum formation; peptidoglycan synthetase; Code: M; COG: COG0768; penicillin-binding protein 3 113833 ftsI 3795920 ftsI Shigella dysenteriae Sd197 penicillin-binding protein 3 YP_401838.1 112067 D 300267 CDS YP_401839.1 82775492 3795921 113820..115307 1 NC_007606.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 115307 murE 3795921 murE Shigella dysenteriae Sd197 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_401839.1 113820 D 300267 CDS YP_401840.1 82775493 3795922 115304..116662 1 NC_007606.1 Code: M; COG: COG0770; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 116662 murF 3795922 murF Shigella dysenteriae Sd197 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_401840.1 115304 D 300267 CDS YP_401841.1 82775494 3795923 116656..117738 1 NC_007606.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 117738 mraY 3795923 mraY Shigella dysenteriae Sd197 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_401841.1 116656 D 300267 CDS YP_401842.1 82775495 3795924 117741..119057 1 NC_007606.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 119057 murD 3795924 murD Shigella dysenteriae Sd197 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_401842.1 117741 D 300267 CDS YP_401843.1 82775496 3799344 119057..120301 1 NC_007606.1 cell division; membrane protein involved in shape determination; integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 120301 ftsW 3799344 ftsW Shigella dysenteriae Sd197 cell division protein FtsW YP_401843.1 119057 D 300267 CDS YP_401844.1 82775497 3799345 120298..121365 1 NC_007606.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 121365 murG 3799345 murG Shigella dysenteriae Sd197 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_401844.1 120298 D 300267 CDS YP_401845.1 82775498 3799346 121419..122894 1 NC_007606.1 L-alanine adding enzyme; Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 122894 murC 3799346 murC Shigella dysenteriae Sd197 UDP-N-acetylmuramate--L-alanine ligase YP_401845.1 121419 D 300267 CDS YP_401846.1 82775499 3799347 122887..123807 1 NC_007606.1 affects cell division; D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 123807 ddl 3799347 ddl Shigella dysenteriae Sd197 D-alanine--D-alanine ligase YP_401846.1 122887 D 300267 CDS YP_401847.1 82775500 3799348 123809..124639 1 NC_007606.1 ingrowth of wall at septum; involved in septum formation; cell division protein FtsQ 124639 ftsQ 3799348 ftsQ Shigella dysenteriae Sd197 cell division protein FtsQ YP_401847.1 123809 D 300267 CDS YP_401848.1 82775501 3799349 124636..125898 1 NC_007606.1 septation process, complexes with FtsZ; associated with junctions of inner and outer membranes; ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 125898 ftsA 3799349 ftsA Shigella dysenteriae Sd197 cell division protein FtsA YP_401848.1 124636 D 300267 CDS YP_401849.1 82775502 3799350 125959..127110 1 NC_007606.1 cell division; forms circumferential ring; ''GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function''; cell division protein FtsZ 127110 ftsZ 3799350 ftsZ Shigella dysenteriae Sd197 cell division protein FtsZ YP_401849.1 125959 D 300267 CDS YP_401850.1 82775503 3799351 127211..128128 1 NC_007606.1 lipid A biosynthesis; zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 128128 lpxC 3799351 lpxC Shigella dysenteriae Sd197 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_401850.1 127211 D 300267 CDS YP_401851.2 161950167 3799352 128358..128870 1 NC_007606.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 128870 yacA 3799352 yacA Shigella dysenteriae Sd197 SecA regulator SecM YP_401851.2 128358 D 300267 CDS YP_401852.1 82775505 3799353 128932..131637 1 NC_007606.1 secretion protein; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 131637 secA 3799353 secA Shigella dysenteriae Sd197 preprotein translocase subunit SecA YP_401852.1 128932 D 300267 CDS YP_401853.1 82775506 3799354 131697..132095 1 NC_007606.1 prefers dGTP; causes AT-GC transversions; Code: LR; COG: COG0494; nucleoside triphosphate pyrophosphohydrolase 132095 mutT 3799354 mutT Shigella dysenteriae Sd197 nucleoside triphosphate pyrophosphohydrolase YP_401853.1 131697 D 300267 CDS YP_401854.1 82775507 3799355 complement(132100..132234) 1 NC_007606.1 hypothetical protein 132234 3799355 SDY_0130 Shigella dysenteriae Sd197 hypothetical protein YP_401854.1 132100 R 300267 CDS YP_401855.1 82775508 3799356 complement(132185..132382) 1 NC_007606.1 Code: S; COG: COG3024; zinc-binding protein 132382 yacG 3799356 yacG Shigella dysenteriae Sd197 zinc-binding protein YP_401855.1 132185 R 300267 CDS YP_401856.1 82775509 3799357 complement(132392..133135) 1 NC_007606.1 Code: S; COG: COG4582; hypothetical protein 133135 yacF 3799357 yacF Shigella dysenteriae Sd197 hypothetical protein YP_401856.1 132392 R 300267 CDS YP_401857.1 82775510 3799358 complement(133135..133755) 1 NC_007606.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 133755 coaE 3799358 coaE Shigella dysenteriae Sd197 dephospho-CoA kinase YP_401857.1 133135 R 300267 CDS YP_401858.1 82775511 3799359 133980..135023 1 NC_007606.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 135023 guaC 3799359 guaC Shigella dysenteriae Sd197 guanosine 5'-monophosphate oxidoreductase YP_401858.1 133980 D 300267 CDS YP_401861.1 82775514 3799054 complement(137641..138081) 1 NC_007606.1 Code: NU; COG: COG4969; major pilin subunit 138081 ppdD 3799054 ppdD Shigella dysenteriae Sd197 major pilin subunit YP_401861.1 137641 R 300267 CDS YP_401862.1 82775515 3799055 complement(138284..139177) 1 NC_007606.1 ''catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide''; quinolinate phosphoribosyltransferase 139177 nadC 3799055 nadC Shigella dysenteriae Sd197 quinolinate phosphoribosyltransferase YP_401862.1 138284 R 300267 CDS YP_401863.1 82775516 3799056 139265..139816 1 NC_007606.1 Code: V; COG: COG3023; N-acetyl-anhydromuranmyl-L-alanine amidase 139816 ampD 3799056 ampD Shigella dysenteriae Sd197 N-acetyl-anhydromuranmyl-L-alanine amidase YP_401863.1 139265 D 300267 CDS YP_401864.1 82775517 3799057 139813..140667 1 NC_007606.1 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 140667 ampE 3799057 ampE Shigella dysenteriae Sd197 regulatory protein AmpE YP_401864.1 139813 D 300267 CDS YP_401865.1 82775518 3799058 complement(140710..142083) 1 NC_007606.1 Code: E; COG: COG1113; aromatic amino acid transporter 142083 aroP 3799058 aroP Shigella dysenteriae Sd197 aromatic amino acid transporter YP_401865.1 140710 R 300267 CDS YP_401866.1 82775519 3799059 142624..143388 1 NC_007606.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 143388 pdhR 3799059 pdhR Shigella dysenteriae Sd197 transcriptional regulator PdhR YP_401866.1 142624 D 300267 CDS YP_401867.1 82775520 3799060 143549..146212 1 NC_007606.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 146212 aceE 3799060 aceE Shigella dysenteriae Sd197 pyruvate dehydrogenase subunit E1 YP_401867.1 143549 D 300267 CDS YP_401868.1 82775521 3799061 146227..148107 1 NC_007606.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 148107 aceF 3799061 aceF Shigella dysenteriae Sd197 dihydrolipoamide acetyltransferase YP_401868.1 146227 D 300267 CDS YP_401869.1 82775522 3799062 148315..149739 1 NC_007606.1 component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 149739 lpdA 3799062 lpdA Shigella dysenteriae Sd197 dihydrolipoamide dehydrogenase YP_401869.1 148315 D 300267 CDS YP_401872.1 82775525 3799065 complement(151404..151781) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 151781 insB 3799065 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401872.1 151404 R 300267 CDS YP_401873.1 82775526 3799066 complement(151826..152101) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 152101 insA 3799066 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401873.1 151826 R 300267 CDS YP_401874.1 82775527 3799067 complement(152152..152643) 1 NC_007606.1 hypothetical protein 152643 3799067 SDY_0151 Shigella dysenteriae Sd197 hypothetical protein YP_401874.1 152152 R 300267 CDS YP_401875.1 82775528 3799068 complement(152621..153016) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 153016 3799068 SDY_0152 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_401875.1 152621 R 300267 CDS YP_009000623.1 578793082 18262939 complement(153043..153315) 1 NC_007606.1 insertion element iso-IS1N protein InsA 153315 18262939 SDY0152a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000623.1 153043 R 300267 CDS YP_401877.1 82775530 3799070 153922..154716 1 NC_007606.1 ''catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate''; 3-methyl-2-oxobutanoate hydroxymethyltransferase 154716 panB 3799070 panB Shigella dysenteriae Sd197 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_401877.1 153922 D 300267 CDS YP_401878.1 82775531 3799071 154728..155579 1 NC_007606.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 155579 panC 3799071 panC Shigella dysenteriae Sd197 pantoate--beta-alanine ligase YP_401878.1 154728 D 300267 CDS YP_401879.1 82775532 3799072 156192..156569 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 156569 insB 3799072 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401879.1 156192 D 300267 CDS YP_009000624.1 578793083 18262940 156818..157090 1 NC_007606.1 insertion element iso-IS1N protein InsA 157090 18262940 SDY0156a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000624.1 156818 D 300267 CDS YP_401880.1 82775533 3799073 157117..157512 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 157512 3799073 SDY_0157 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_401880.1 157117 D 300267 CDS YP_401881.1 82775534 3795789 complement(157582..158061) 1 NC_007606.1 ''catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP''; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 158061 folK 3795789 folK Shigella dysenteriae Sd197 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_401881.1 157582 R 300267 CDS YP_401882.2 161950166 3795790 complement(158058..159476) 1 NC_007606.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase 159476 pcnB 3795790 pcnB Shigella dysenteriae Sd197 poly(A) polymerase YP_401882.2 158058 R 300267 CDS YP_401883.2 161950165 3795791 complement(159515..160411) 1 NC_007606.1 ''this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu''; glutamyl-Q tRNA(Asp) synthetase 160411 yadB 3795791 yadB Shigella dysenteriae Sd197 glutamyl-Q tRNA(Asp) synthetase YP_401883.2 159515 R 300267 CDS YP_401884.1 82775537 3795792 complement(160478..160933) 1 NC_007606.1 Code: T; COG: COG1734; DnaK transcriptional regulator DksA 160933 dksA 3795792 dksA Shigella dysenteriae Sd197 DnaK transcriptional regulator DksA YP_401884.1 160478 R 300267 CDS YP_401885.1 82775538 3795793 complement(161111..161815) 1 NC_007606.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 161815 sfsA 3795793 sfsA Shigella dysenteriae Sd197 sugar fermentation stimulation protein A YP_401885.1 161111 R 300267 CDS YP_401886.1 82775539 3795794 complement(161830..162369) 1 NC_007606.1 Code: J; COG: COG1514; hypothetical protein 162369 yadP 3795794 yadP Shigella dysenteriae Sd197 hypothetical protein YP_401886.1 161830 R 300267 CDS YP_401887.1 82775540 3795796 165059..167593 1 NC_007606.1 penicillin-binding protein 1B; ''bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell''; penicillin-binding protein 1b 167593 mrcB 3795796 mrcB Shigella dysenteriae Sd197 penicillin-binding protein 1b YP_401887.1 165059 D 300267 CDS YP_401888.1 82775541 3795797 167813..170056 1 NC_007606.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 170056 fhuA 3795797 fhuA Shigella dysenteriae Sd197 ferrichrome outer membrane transporter YP_401888.1 167813 D 300267 CDS YP_401889.1 82775542 3795798 170107..170904 1 NC_007606.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate ABC transporter ATP-binding protein 170904 fhuC 3795798 fhuC Shigella dysenteriae Sd197 iron-hydroxamate ABC transporter ATP-binding protein YP_401889.1 170107 D 300267 CDS YP_401890.1 82775543 3795799 170904..171794 1 NC_007606.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate ABC transporter substrate-binding protein 171794 fhuD 3795799 fhuD Shigella dysenteriae Sd197 iron-hydroxamate ABC transporter substrate-binding protein YP_401890.1 170904 D 300267 CDS YP_401891.1 82775544 3795800 171791..173773 1 NC_007606.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate ABC transporter permease 173773 fhuB 3795800 fhuB Shigella dysenteriae Sd197 iron-hydroxamate ABC transporter permease YP_401891.1 171791 D 300267 CDS YP_401892.1 82775545 3795801 complement(173808..175088) 1 NC_007606.1 aminomutase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 175088 hemL 3795801 hemL Shigella dysenteriae Sd197 glutamate-1-semialdehyde aminotransferase YP_401892.1 173808 R 300267 CDS YP_401893.1 82775546 3795802 175313..176734 1 NC_007606.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 176734 yadQ 3795802 yadQ Shigella dysenteriae Sd197 chloride channel protein YP_401893.1 175313 D 300267 CDS YP_401894.1 82775547 3795803 176816..177160 1 NC_007606.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 177160 yadR 3795803 yadR Shigella dysenteriae Sd197 iron-sulfur cluster insertion protein ErpA YP_401894.1 176816 D 300267 CDS YP_401895.1 82775548 3795804 complement(177207..177830) 1 NC_007606.1 Code: S; COG: COG2860; hypothetical protein 177830 yadS 3795804 yadS Shigella dysenteriae Sd197 hypothetical protein YP_401895.1 177207 R 300267 CDS YP_401896.1 82775549 3795805 complement(177868..178668) 1 NC_007606.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 178668 yadT 3795805 yadT Shigella dysenteriae Sd197 vitamin B12-transporter protein BtuF YP_401896.1 177868 R 300267 CDS YP_401897.1 82775550 3795806 complement(178661..179359) 1 NC_007606.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 179359 pfs 3795806 pfs Shigella dysenteriae Sd197 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_401897.1 178661 R 300267 CDS YP_009000625.1 578793084 18262941 180498..180770 1 NC_007606.1 insertion element iso-IS1N protein InsA 180770 18262941 SDY_0177a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000625.1 180498 D 300267 CDS YP_401898.1 82775551 3798524 180797..181192 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 181192 3798524 SDY_0177 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_401898.1 180797 D 300267 CDS YP_401899.1 82775552 3798525 181864..183288 1 NC_007606.1 heat shock protein HtrA; protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 183288 htrA 3798525 htrA Shigella dysenteriae Sd197 serine endoprotease YP_401899.1 181864 D 300267 CDS YP_401902.1 82775555 3798528 complement(184685..185071) 1 NC_007606.1 hypothetical protein 185071 yaeH 3798528 yaeH Shigella dysenteriae Sd197 hypothetical protein YP_401902.1 184685 R 300267 CDS YP_401903.1 82775556 3798529 complement(185385..186209) 1 NC_007606.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 186209 dapD 3798529 dapD Shigella dysenteriae Sd197 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_401903.1 185385 R 300267 CDS YP_401904.1 82775557 3798530 complement(186240..188912) 1 NC_007606.1 uridylyltransferase acts on regulator of glnA; catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 188912 glnD 3798530 glnD Shigella dysenteriae Sd197 PII uridylyl-transferase YP_401904.1 186240 R 300267 CDS YP_401905.1 82775558 3798531 complement(188974..189768) 1 NC_007606.1 ''catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn''; methionine aminopeptidase 189768 map 3798531 map Shigella dysenteriae Sd197 methionine aminopeptidase YP_401905.1 188974 R 300267 CDS YP_401906.1 82775559 3798532 190136..190861 1 NC_007606.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 190861 rpsB 3798532 rpsB Shigella dysenteriae Sd197 30S ribosomal protein S2 YP_401906.1 190136 D 300267 CDS YP_401907.1 82775560 3798533 191119..191970 1 NC_007606.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 191970 tsf 3798533 tsf Shigella dysenteriae Sd197 elongation factor Ts YP_401907.1 191119 D 300267 CDS YP_401908.1 82775561 3798534 192117..192842 1 NC_007606.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 192842 pyrH 3798534 pyrH Shigella dysenteriae Sd197 uridylate kinase YP_401908.1 192117 D 300267 CDS YP_401909.1 82775562 3798535 193134..193691 1 NC_007606.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 193691 frr 3798535 frr Shigella dysenteriae Sd197 ribosome recycling factor YP_401909.1 193134 D 300267 CDS YP_401910.1 82775563 3798536 193783..194979 1 NC_007606.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 194979 yaeM 3798536 yaeM Shigella dysenteriae Sd197 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_401910.1 193783 D 300267 CDS YP_401911.1 82775564 3798537 195165..195926 1 NC_007606.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 195926 yaeS 3798537 yaeS Shigella dysenteriae Sd197 undecaprenyl pyrophosphate synthase YP_401911.1 195165 D 300267 CDS YP_401912.2 161950164 3798538 195939..196796 1 NC_007606.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 196796 cdsA 3798538 cdsA Shigella dysenteriae Sd197 CDP-diglyceride synthase YP_401912.2 195939 D 300267 CDS YP_401913.1 82775566 3798539 196808..198160 1 NC_007606.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 198160 yaeL 3798539 yaeL Shigella dysenteriae Sd197 zinc metallopeptidase RseP YP_401913.1 196808 D 300267 CDS YP_401914.1 82775567 3798540 198190..200622 1 NC_007606.1 ''part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins''; outer membrane protein assembly factor YaeT 200622 yaeT 3798540 yaeT Shigella dysenteriae Sd197 outer membrane protein assembly factor YaeT YP_401914.1 198190 D 300267 CDS YP_401915.1 82775568 3798541 200744..201229 1 NC_007606.1 located in outer membrane or nucleoid; Code: M; COG: COG2825; periplasmic chaperone 201229 hlpA 3798541 hlpA Shigella dysenteriae Sd197 periplasmic chaperone YP_401915.1 200744 D 300267 CDS YP_401916.1 82775569 3798542 201233..202258 1 NC_007606.1 third step of endotoxin (lipidA) synthesis; adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 202258 lpxD 3798542 lpxD Shigella dysenteriae Sd197 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_401916.1 201233 D 300267 CDS YP_401917.1 82775570 3798543 202363..202818 1 NC_007606.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 202818 fabZ 3798543 fabZ Shigella dysenteriae Sd197 (3R)-hydroxymyristoyl-ACP dehydratase YP_401917.1 202363 D 300267 CDS YP_401918.1 82775571 3795730 202822..203610 1 NC_007606.1 lipid A biosynthesis; catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 203610 lpxA 3795730 lpxA Shigella dysenteriae Sd197 UDP-N-acetylglucosamine acyltransferase YP_401918.1 202822 D 300267 CDS YP_401919.1 82775572 3795731 203610..204758 1 NC_007606.1 lipid A biosynthesis, penultimate step; ''catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM''; lipid-A-disaccharide synthase 204758 lpxB 3795731 lpxB Shigella dysenteriae Sd197 lipid-A-disaccharide synthase YP_401919.1 203610 D 300267 CDS YP_401920.1 82775573 3795732 204755..205351 1 NC_007606.1 degrades RNA of DNA-RNA hybrids; RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 205351 rnhB 3795732 rnhB Shigella dysenteriae Sd197 ribonuclease HII YP_401920.1 204755 D 300267 CDS YP_401921.1 82775574 3795733 205388..208870 1 NC_007606.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 208870 dnaE 3795733 dnaE Shigella dysenteriae Sd197 DNA polymerase III subunit alpha YP_401921.1 205388 D 300267 CDS YP_401922.1 82775575 3795734 208883..209842 1 NC_007606.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 209842 accA 3795734 accA Shigella dysenteriae Sd197 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_401922.1 208883 D 300267 CDS YP_401923.1 82775576 3795735 210154..210429 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 210429 insA 3795735 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401923.1 210154 D 300267 CDS YP_401924.1 82775577 3795736 210474..210851 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 210851 insB 3795736 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401924.1 210474 D 300267 CDS YP_401925.1 82775578 3795738 212959..213291 1 NC_007606.1 Code: E; COG: COG0346; hypothetical protein 213291 yaeR 3795738 yaeR Shigella dysenteriae Sd197 hypothetical protein YP_401925.1 212959 D 300267 CDS YP_401926.1 82775579 3795739 213359..214654 1 NC_007606.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 214654 tilS 3795739 tilS Shigella dysenteriae Sd197 tRNA(Ile)-lysidine synthetase YP_401926.1 213359 D 300267 CDS YP_401927.1 82775580 3795740 complement(214707..214967) 1 NC_007606.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 214967 yaeO 3795740 yaeO Shigella dysenteriae Sd197 Rho-binding antiterminator YP_401927.1 214707 R 300267 CDS YP_401928.1 82775581 3795741 complement(214954..215172) 1 NC_007606.1 hypothetical protein 215172 yaeP 3795741 yaeP Shigella dysenteriae Sd197 hypothetical protein YP_401928.1 214954 R 300267 CDS YP_401929.1 82775582 3795742 215320..215865 1 NC_007606.1 Code: S; COG: COG4681; hypothetical protein 215865 yaeQ 3795742 yaeQ Shigella dysenteriae Sd197 hypothetical protein YP_401929.1 215320 D 300267 CDS YP_401930.1 82775583 3795743 215862..216284 1 NC_007606.1 Code: J; COG: COG1186; peptidyl-tRNA hydrolase domain-containing protein 216284 yaeJ 3795743 yaeJ Shigella dysenteriae Sd197 peptidyl-tRNA hydrolase domain-containing protein YP_401930.1 215862 D 300267 CDS YP_401931.1 82775584 3795744 216298..217008 1 NC_007606.1 lipoprotein; Code: MP; COG: COG3015; copper homeostasis and adhesion lipoprotein 217008 cutF 3795744 cutF Shigella dysenteriae Sd197 copper homeostasis and adhesion lipoprotein YP_401931.1 216298 D 300267 CDS YP_401932.1 82775585 3795745 complement(217152..217976) 1 NC_007606.1 hypothetical protein 217976 yaeF 3795745 yaeF Shigella dysenteriae Sd197 hypothetical protein YP_401932.1 217152 R 300267 CDS YP_401933.1 82775586 3795746 complement(218029..219747) 1 NC_007606.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 219747 proS 3795746 proS Shigella dysenteriae Sd197 prolyl-tRNA synthetase YP_401933.1 218029 R 300267 CDS YP_401934.1 82775587 3795747 complement(219858..220565) 1 NC_007606.1 Code: S; COG: COG1720; hypothetical protein 220565 yaeB 3795747 yaeB Shigella dysenteriae Sd197 hypothetical protein YP_401934.1 219858 R 300267 CDS YP_401935.1 82775588 3795748 complement(220562..220966) 1 NC_007606.1 interacts with RcsB; outer membrane lipoprotein 220966 rcsF 3795748 rcsF Shigella dysenteriae Sd197 outer membrane lipoprotein YP_401935.1 220562 R 300267 CDS YP_401936.1 82775589 3797846 complement(221084..221899) 1 NC_007606.1 Code: P; COG: COG1464; DL-methionine ABC transporter substrate-binding protein 221899 metQ 3797846 metQ Shigella dysenteriae Sd197 DL-methionine ABC transporter substrate-binding protein YP_401936.1 221084 R 300267 CDS YP_401937.1 82775590 3797847 complement(221939..222592) 1 NC_007606.1 part of the MetNIQ methionine uptake system; DL-methionine ABC transporter permease 222592 yaeE 3797847 yaeE Shigella dysenteriae Sd197 DL-methionine ABC transporter permease YP_401937.1 221939 R 300267 CDS YP_401938.1 82775591 3797848 complement(222585..223616) 1 NC_007606.1 part of the metNIQ transport system for methionine; DL-methionine ABC transporter ATP-binding protein 223616 metN 3797848 metN Shigella dysenteriae Sd197 DL-methionine ABC transporter ATP-binding protein YP_401938.1 222585 R 300267 CDS YP_401939.1 82775592 3797849 223804..224376 1 NC_007606.1 ''Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate''; D,D-heptose 1,7-bisphosphate phosphatase 224376 yaeD 3797849 yaeD Shigella dysenteriae Sd197 D,D-heptose 1,7-bisphosphate phosphatase YP_401939.1 223804 D 300267 CDS YP_401940.1 82775593 3797856 230128..230895 1 NC_007606.1 ''catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid''; 2,5-diketo-D-gluconate reductase B 230895 dkgB 3797856 dkgB Shigella dysenteriae Sd197 2,5-diketo-D-gluconate reductase B YP_401940.1 230128 D 300267 CDS YP_401941.1 82775594 3797857 complement(230927..231841) 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 231841 yafC 3797857 yafC Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_401941.1 230927 R 300267 CDS YP_401942.1 82775595 3797858 232082..232882 1 NC_007606.1 Code: S; COG: COG3021; hypothetical protein 232882 yafD 3797858 yafD Shigella dysenteriae Sd197 hypothetical protein YP_401942.1 232082 D 300267 CDS YP_401944.1 82775597 3796958 complement(233762..235120) 1 NC_007606.1 cytochrome c552; ''catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall''; membrane-bound lytic murein transglycosylase D 235120 mltD 3796958 mltD Shigella dysenteriae Sd197 membrane-bound lytic murein transglycosylase D YP_401944.1 233762 R 300267 CDS YP_401945.1 82775598 3796959 complement(235192..235947) 1 NC_007606.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 235947 gloB 3796959 gloB Shigella dysenteriae Sd197 hydroxyacylglutathione hydrolase YP_401945.1 235192 R 300267 CDS YP_401946.1 82775599 3796960 235963..236703 1 NC_007606.1 Code: QR; COG: COG0500; hypothetical protein 236703 yafS 3796960 yafS Shigella dysenteriae Sd197 hypothetical protein YP_401946.1 235963 D 300267 CDS YP_401947.1 82775600 3796961 complement(236700..237167) 1 NC_007606.1 degrades RNA of DNA-RNA hybrids, participates in DNA replication; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 237167 rnhA 3796961 rnhA Shigella dysenteriae Sd197 ribonuclease H YP_401947.1 236700 R 300267 CDS YP_401948.1 82775601 3796962 237232..237963 1 NC_007606.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 237963 dnaQ 3796962 dnaQ Shigella dysenteriae Sd197 DNA polymerase III subunit epsilon YP_401948.1 237232 D 300267 CDS YP_401949.1 82775602 3796964 complement(238404..238781) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 238781 insB 3796964 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401949.1 238404 R 300267 CDS YP_401950.1 82775603 3796965 complement(238826..239101) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 239101 insA 3796965 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401950.1 238826 R 300267 CDS YP_401951.1 82775604 3796966 complement(239152..239412) 1 NC_007606.1 hypothetical protein 239412 3796966 SDY_0238 Shigella dysenteriae Sd197 hypothetical protein YP_401951.1 239152 R 300267 CDS YP_009000626.1 578793085 18262942 complement(239971..240243) 1 NC_007606.1 insertion element iso-IS1N protein InsA 240243 18262942 SDY_0241a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000626.1 239971 R 300267 CDS YP_009000627.1 578793086 18262943 241442..241714 1 NC_007606.1 insertion element iso-IS1N protein InsA 241714 18262943 SDY0242a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000627.1 241442 D 300267 CDS YP_401955.2 161950163 3796970 241741..242136 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 242136 3796970 SDY_0242 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_401955.2 241741 D 300267 CDS YP_401958.1 82775611 3796973 complement(243525..244295) 1 NC_007606.1 Code: R; COG: COG0388; hypothetical protein 244295 yafV 3796973 yafV Shigella dysenteriae Sd197 hypothetical protein YP_401958.1 243525 R 300267 CDS YP_401959.1 82775612 3796974 244449..244922 1 NC_007606.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 244922 ykfE 3796974 ykfE Shigella dysenteriae Sd197 C-lysozyme inhibitor YP_401959.1 244449 D 300267 CDS YP_401960.1 82775613 3799596 247649..248227 1 NC_007606.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 248227 gmhA 3799596 gmhA Shigella dysenteriae Sd197 phosphoheptose isomerase YP_401960.1 247649 D 300267 CDS YP_401961.1 82775614 3799597 248433..249200 1 NC_007606.1 Code: R; COG: COG0121; amidotransferase 249200 yafJ 3799597 yafJ Shigella dysenteriae Sd197 amidotransferase YP_401961.1 248433 D 300267 CDS YP_401962.1 82775615 3799598 complement(249171..249911) 1 NC_007606.1 Code: S; COG: COG3034; hypothetical protein 249911 yafK 3799598 yafK Shigella dysenteriae Sd197 hypothetical protein YP_401962.1 249171 R 300267 CDS YP_401963.1 82775616 3799599 complement(250067..250345) 1 NC_007606.1 Code: S; COG: COG3041; hypothetical protein 250345 yafQ 3799599 yafQ Shigella dysenteriae Sd197 hypothetical protein YP_401963.1 250067 R 300267 CDS YP_401964.1 82775617 3799600 complement(250348..250608) 1 NC_007606.1 Code: L; COG: COG3077; damage-inducible protein J 250608 dinJ 3799600 dinJ Shigella dysenteriae Sd197 damage-inducible protein J YP_401964.1 250348 R 300267 CDS YP_401965.1 82775618 3799601 250818..251567 1 NC_007606.1 Code: M; COG: COG0791; lipoprotein 251567 yafL 3799601 yafL Shigella dysenteriae Sd197 lipoprotein YP_401965.1 250818 D 300267 CDS YP_401966.1 82775619 3799602 251743..252081 1 NC_007606.1 Code: L; COG: COG1943; hypothetical protein 252081 yafM 3799602 yafM Shigella dysenteriae Sd197 hypothetical protein YP_401966.1 251743 D 300267 CDS YP_009000628.1 578793087 18262944 252117..252389 1 NC_007606.1 insertion element iso-IS1N protein InsA 252389 18262944 SDY_0254a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000628.1 252117 D 300267 CDS YP_401967.1 82775620 3799603 252416..252811 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 252811 3799603 SDY_0255 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_401967.1 252416 D 300267 CDS YP_401968.1 82775621 3799604 253042..253407 1 NC_007606.1 Code: NU; COG: COG3121; chaperone 253407 sfmC 3799604 sfmC Shigella dysenteriae Sd197 chaperone YP_401968.1 253042 D 300267 CDS YP_401969.1 82775622 3799605 253441..253716 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 253716 insA 3799605 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401969.1 253441 D 300267 CDS YP_401970.1 82775623 3799606 253761..254138 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 254138 insB 3799606 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401970.1 253761 D 300267 CDS YP_401971.1 82775624 3799608 complement(254653..255048) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 255048 3799608 SDY_0260 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_401971.1 254653 R 300267 CDS YP_009000629.1 578793088 18262945 complement(255075..255347) 1 NC_007606.1 insertion element iso-IS1N protein InsA 255347 18262945 SDY_0260a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000629.1 255075 R 300267 CDS YP_009000630.1 578793089 18262946 255702..255974 1 NC_007606.1 insertion element iso-IS1N protein InsA 255974 18262946 SDY_0263a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000630.1 255702 D 300267 CDS YP_401972.1 82775625 3799609 256001..256396 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 256396 3799609 SDY_0261 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_401972.1 256001 D 300267 CDS YP_009000631.1 578793090 3799844 263221..263598 1 NC_007606.1 insertion element iso-IS1d protein InsB 263598 insB 3799844 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_009000631.1 263221 D 300267 CDS YP_401977.1 82775630 3799845 263934..265604 1 NC_007606.1 involved in protein transport; multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 265604 fdrA 3799845 fdrA Shigella dysenteriae Sd197 membrane protein FdrA YP_401977.1 263934 D 300267 CDS YP_401978.2 578793091 3799846 265614..266873 1 NC_007606.1 hypothetical protein 266873 ylbE 3799846 ylbE Shigella dysenteriae Sd197 hypothetical protein YP_401978.2 265614 D 300267 CDS YP_401979.1 82775632 3799847 266884..267699 1 NC_007606.1 carboxylase 267699 ylbF 3799847 ylbF Shigella dysenteriae Sd197 carboxylase YP_401979.1 266884 D 300267 CDS YP_401980.1 82775633 3799849 complement(267968..268345) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 268345 insB 3799849 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_401980.1 267968 R 300267 CDS YP_401981.1 82775634 3799850 complement(268390..268665) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 268665 insA 3799850 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401981.1 268390 R 300267 CDS YP_401982.1 82775635 3799851 complement(269505..270572) 1 NC_007606.1 phosphoribosylaminoimidazole carboxylase; With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 270572 purK 3799851 purK Shigella dysenteriae Sd197 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_401982.1 269505 R 300267 CDS YP_401983.1 82775636 3799852 complement(270569..271078) 1 NC_007606.1 phosphoribosylaminoimidazole carboxylase; Code: F; COG: COG0041; AIR carboxylase, catalytic subunit 271078 purE 3799852 purE Shigella dysenteriae Sd197 AIR carboxylase, catalytic subunit YP_401983.1 270569 R 300267 CDS YP_401984.1 82775637 3799853 complement(271196..271918) 1 NC_007606.1 ''catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine''; UDP-2,3-diacylglucosamine hydrolase 271918 ybbF 3799853 ybbF Shigella dysenteriae Sd197 UDP-2,3-diacylglucosamine hydrolase YP_401984.1 271196 R 300267 CDS YP_401985.1 82775638 3799854 complement(271921..272415) 1 NC_007606.1 rotamase B; Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase B 272415 ppiB 3799854 ppiB Shigella dysenteriae Sd197 peptidyl-prolyl cis-trans isomerase B YP_401985.1 271921 R 300267 CDS YP_401986.1 82775639 3799855 272589..273974 1 NC_007606.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 273974 cysS 3799855 cysS Shigella dysenteriae Sd197 cysteinyl-tRNA synthetase YP_401986.1 272589 D 300267 CDS YP_401988.1 82775641 3799857 complement(274483..274872) 1 NC_007606.1 Code: S; COG: COG2501; hypothetical protein 274872 ybcJ 3799857 ybcJ Shigella dysenteriae Sd197 hypothetical protein YP_401988.1 274483 R 300267 CDS YP_401989.1 82775642 3799858 complement(274853..275719) 1 NC_007606.1 5,10-methylene-tetrahydrofolate cyclohydrolase; Code: H; COG: COG0190; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 275719 folD 3799858 folD Shigella dysenteriae Sd197 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_401989.1 274853 R 300267 CDS YP_401990.1 82775643 3799859 complement(276328..276603) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 276603 insA 3799859 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_401990.1 276328 R 300267 CDS YP_401991.1 82775644 3799860 complement(276714..277427) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 277427 3799860 SDY_0283 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_401991.1 276714 R 300267 CDS YP_401992.1 82775645 3799861 complement(277568..277870) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 277870 3799861 SDY_0284 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_401992.1 277568 R 300267 CDS YP_401994.1 82775647 3798960 279904..280599 1 NC_007606.1 ''YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His''; queuosine biosynthesis protein QueC 280599 ybaX 3798960 ybaX Shigella dysenteriae Sd197 queuosine biosynthesis protein QueC YP_401994.1 279904 D 300267 CDS YP_401995.1 82775648 3798961 complement(280651..281049) 1 NC_007606.1 Code: R; COG: COG0824; hypothetical protein 281049 ybaW 3798961 ybaW Shigella dysenteriae Sd197 hypothetical protein YP_401995.1 280651 R 300267 CDS YP_009000632.1 578793092 18262947 complement(281510..281782) 1 NC_007606.1 insertion element iso-IS1N protein InsA 281782 18262947 SDY_0288a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000632.1 281510 R 300267 CDS YP_401998.1 82775651 3798964 complement(281930..282301) 1 NC_007606.1 Code: L; COG: COG1555; hypothetical protein 282301 ybaV 3798964 ybaV Shigella dysenteriae Sd197 hypothetical protein YP_401998.1 281930 R 300267 CDS YP_401999.1 82775652 3798965 complement(282452..284323) 1 NC_007606.1 Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase 284323 ybaU 3798965 ybaU Shigella dysenteriae Sd197 peptidyl-prolyl cis-trans isomerase YP_401999.1 282452 R 300267 CDS YP_402000.1 82775653 3798966 complement(284515..284787) 1 NC_007606.1 NS1 (HU-1); histone-like DNA-binding protein; transcriptional regulator HU subunit beta 284787 hupB 3798966 hupB Shigella dysenteriae Sd197 transcriptional regulator HU subunit beta YP_402000.1 284515 R 300267 CDS YP_402001.1 82775654 3798967 complement(284921..287359) 1 NC_007606.1 heat shock K-protein; Code: O; COG: COG0466; DNA-binding ATP-dependent protease La 287359 lon 3798967 lon Shigella dysenteriae Sd197 DNA-binding ATP-dependent protease La YP_402001.1 284921 R 300267 CDS YP_402002.1 82775655 3798968 complement(287547..288821) 1 NC_007606.1 chaperone; binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 288821 clpX 3798968 clpX Shigella dysenteriae Sd197 ATP-dependent protease ATP-binding subunit ClpX YP_402002.1 287547 R 300267 CDS YP_402003.1 82775656 3798969 complement(288947..289570) 1 NC_007606.1 heat shock protein F21.5; ''hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates''; ATP-dependent Clp protease proteolytic subunit 289570 clpP 3798969 clpP Shigella dysenteriae Sd197 ATP-dependent Clp protease proteolytic subunit YP_402003.1 288947 R 300267 CDS YP_402004.1 82775657 3798970 complement(289815..291113) 1 NC_007606.1 a molecular chaperone involved in cell division; Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 291113 tig 3798970 tig Shigella dysenteriae Sd197 trigger factor YP_402004.1 289815 R 300267 CDS YP_402006.2 161950162 3798972 complement(291457..291774) 1 NC_007606.1 ''positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress''; transcriptional regulator BolA 291774 bolA 3798972 bolA Shigella dysenteriae Sd197 transcriptional regulator BolA YP_402006.2 291457 R 300267 CDS YP_402007.2 161950161 3798973 292079..292657 1 NC_007606.1 Code: M; COG: COG3056; hypothetical protein 292657 yajG 3798973 yajG Shigella dysenteriae Sd197 hypothetical protein YP_402007.2 292079 D 300267 CDS YP_402008.1 82775661 3798974 292701..294176 1 NC_007606.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 294176 ampG 3798974 ampG Shigella dysenteriae Sd197 muropeptide transporter YP_402008.1 292701 D 300267 CDS YP_402009.1 82775662 3798975 complement(294273..294668) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 294668 3798975 SDY_0301 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402009.1 294273 R 300267 CDS YP_009000633.1 578793093 18262948 complement(294695..294967) 1 NC_007606.1 insertion element iso-IS1N protein InsA 294967 18262948 SDY_0303a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000633.1 294695 R 300267 CDS YP_402011.1 82775664 3798977 295062..296432 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 296432 yajR 3798977 yajR Shigella dysenteriae Sd197 transport protein YP_402011.1 295062 D 300267 CDS YP_402012.2 161950160 3798978 complement(296560..297051) 1 NC_007606.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 297051 yajQ 3798978 yajQ Shigella dysenteriae Sd197 nucleotide-binding protein YP_402012.2 296560 R 300267 CDS YP_402013.1 82775666 3798979 297219..298130 1 NC_007606.1 involved in thiamin biosynthesis; alternative pyrimidine biosynthesis; ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 298130 apbA 3798979 apbA Shigella dysenteriae Sd197 2-dehydropantoate 2-reductase YP_402013.1 297219 D 300267 CDS YP_402014.1 82775667 3799690 298087..298683 1 NC_007606.1 Code: R; COG: COG0693; hypothetical protein 298683 thiJ 3799690 thiJ Shigella dysenteriae Sd197 hypothetical protein YP_402014.1 298087 D 300267 CDS YP_402015.1 82775668 3799691 complement(298737..300185) 1 NC_007606.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 300185 yajK 3799691 yajK Shigella dysenteriae Sd197 thiamine biosynthesis protein ThiI YP_402015.1 298737 R 300267 CDS YP_402016.1 82775669 3799692 300391..300633 1 NC_007606.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 300633 xseB 3799692 xseB Shigella dysenteriae Sd197 exodeoxyribonuclease VII small subunit YP_402016.1 300391 D 300267 CDS YP_402017.1 82775670 3799693 300633..301532 1 NC_007606.1 farnesyldiphosphate synthase; Code: H; COG: COG0142; geranyltranstransferase 301532 ispA 3799693 ispA Shigella dysenteriae Sd197 geranyltranstransferase YP_402017.1 300633 D 300267 CDS YP_402018.1 82775671 3799694 301557..303419 1 NC_007606.1 flavoprotein; catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 303419 dxs 3799694 dxs Shigella dysenteriae Sd197 1-deoxy-D-xylulose-5-phosphate synthase YP_402018.1 301557 D 300267 CDS YP_402019.1 82775672 3799695 303474..304448 1 NC_007606.1 Code: C; COG: COG0667; NAD(P)H-dependent xylose reductase 304448 yajO 3799695 yajO Shigella dysenteriae Sd197 NAD(P)H-dependent xylose reductase YP_402019.1 303474 D 300267 CDS YP_009000634.1 578793094 18262949 304526..304798 1 NC_007606.1 insertion element iso-IS1N protein InsA 304798 18262949 SDY_0311a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000634.1 304526 D 300267 CDS YP_402020.1 82775673 3799696 304825..305220 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 305220 3799696 SDY_0312 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402020.1 304825 D 300267 CDS YP_402021.1 82775674 3799697 305221..305625 1 NC_007606.1 hypothetical protein 305625 3799697 SDY_0313 Shigella dysenteriae Sd197 hypothetical protein YP_402021.1 305221 D 300267 CDS YP_402022.1 82775675 3799698 complement(305622..306017) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 306017 3799698 SDY_0314 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402022.1 305622 R 300267 CDS YP_009000635.1 578793095 18262950 complement(306044..306316) 1 NC_007606.1 insertion element iso-IS1N protein InsA 306316 18262950 SDY_0314a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000635.1 306044 R 300267 CDS YP_402023.1 82775676 3799699 306388..306627 1 NC_007606.1 hypothetical protein 306627 3799699 SDY_0315 Shigella dysenteriae Sd197 hypothetical protein YP_402023.1 306388 D 300267 CDS YP_402024.1 82775677 3799700 complement(306805..307320) 1 NC_007606.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 307320 pgpA 3799700 pgpA Shigella dysenteriae Sd197 phosphatidylglycerophosphatase A YP_402024.1 306805 R 300267 CDS YP_402025.1 82775678 3799701 complement(307298..308275) 1 NC_007606.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 308275 thiL 3799701 thiL Shigella dysenteriae Sd197 thiamine monophosphate kinase YP_402025.1 307298 R 300267 CDS YP_402026.1 82775679 3799702 complement(308353..308772) 1 NC_007606.1 transcription termination; L factor; Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 308772 nusB 3799702 nusB Shigella dysenteriae Sd197 transcription antitermination protein NusB YP_402026.1 308353 R 300267 CDS YP_402027.1 82775680 3799703 complement(308792..309262) 1 NC_007606.1 ''RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not''; 6,7-dimethyl-8-ribityllumazine synthase 309262 ribH 3799703 ribH Shigella dysenteriae Sd197 6,7-dimethyl-8-ribityllumazine synthase YP_402027.1 308792 R 300267 CDS YP_402028.1 82775681 3799704 complement(309351..310454) 1 NC_007606.1 in pathway of riboflavin synthesis; ''riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil''; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 310454 ribD 3799704 ribD Shigella dysenteriae Sd197 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_402028.1 309351 R 300267 CDS YP_402029.1 82775682 3799705 complement(310458..310907) 1 NC_007606.1 Code: K; COG: COG1327; transcriptional regulator NrdR 310907 nrdR 3799705 nrdR Shigella dysenteriae Sd197 transcriptional regulator NrdR YP_402029.1 310458 R 300267 CDS YP_402030.2 161950159 3799706 311058..311597 1 NC_007606.1 hypothetical protein 311597 yajI 3799706 yajI Shigella dysenteriae Sd197 hypothetical protein YP_402030.2 311058 D 300267 CDS YP_402031.1 82775684 3799707 311896..312780 1 NC_007606.1 receptor of phage T6 and colicin K; Code: M; COG: COG3248; nucleoside channel 312780 tsx 3799707 tsx Shigella dysenteriae Sd197 nucleoside channel YP_402031.1 311896 D 300267 CDS YP_402032.1 82775685 3799708 complement(312957..313304) 1 NC_007606.1 Code: V; COG: COG1403; hypothetical protein 313304 yajD 3799708 yajD Shigella dysenteriae Sd197 hypothetical protein YP_402032.1 312957 R 300267 CDS YP_402033.1 82775686 3797461 complement(313433..314404) 1 NC_007606.1 ''forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF''; preprotein translocase subunit SecF 314404 secF 3797461 secF Shigella dysenteriae Sd197 preprotein translocase subunit SecF YP_402033.1 313433 R 300267 CDS YP_402034.1 82775687 3797462 complement(314415..316262) 1 NC_007606.1 protein secretion; membrane protein, part of the channel; ''part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane''; preprotein translocase subunit SecD 316262 secD 3797462 secD Shigella dysenteriae Sd197 preprotein translocase subunit SecD YP_402034.1 314415 R 300267 CDS YP_402035.1 82775688 3797463 complement(316290..316622) 1 NC_007606.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 316622 yajC 3797463 yajC Shigella dysenteriae Sd197 preprotein translocase subunit YajC YP_402035.1 316290 R 300267 CDS YP_402036.1 82775689 3797464 complement(316645..317772) 1 NC_007606.1 ''Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)''; queuine tRNA-ribosyltransferase 317772 tgt 3797464 tgt Shigella dysenteriae Sd197 queuine tRNA-ribosyltransferase YP_402036.1 316645 R 300267 CDS YP_402037.1 82775690 3797465 complement(317827..318897) 1 NC_007606.1 synthesis of queuine in tRNA; Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 318897 queA 3797465 queA Shigella dysenteriae Sd197 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_402037.1 317827 R 300267 CDS YP_009000636.1 578793096 18262951 320045..320317 1 NC_007606.1 insertion element iso-IS1N protein InsA 320317 18262951 SDY_0332a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000636.1 320045 D 300267 CDS YP_402042.1 82775695 3797471 complement(322222..323595) 1 NC_007606.1 ''cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation''; proline-specific permease 323595 proY 3797471 proY Shigella dysenteriae Sd197 proline-specific permease YP_402042.1 322222 R 300267 CDS YP_402043.1 82775696 3797472 complement(323671..324990) 1 NC_007606.1 Code: E; COG: COG1114; branched chain amino acid transport system II carrier protein 324990 brnQ 3797472 brnQ Shigella dysenteriae Sd197 branched chain amino acid transport system II carrier protein YP_402043.1 323671 R 300267 CDS YP_402044.1 82775697 3797474 complement(326751..327440) 1 NC_007606.1 sensor is PhoR (or CreC); two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 327440 phoB 3797474 phoB Shigella dysenteriae Sd197 transcriptional regulator PhoB YP_402044.1 326751 R 300267 CDS YP_402045.1 82775698 3797476 complement(328417..329763) 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 329763 3797476 SDY_0340 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_402045.1 328417 R 300267 CDS YP_402046.1 82775699 3797477 330267..333404 1 NC_007606.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 333404 sbcC 3797477 sbcC Shigella dysenteriae Sd197 exonuclease SbcC YP_402046.1 330267 D 300267 CDS YP_402047.2 161950158 3797479 334611..335006 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 335006 3797479 SDY_0343 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402047.2 334611 D 300267 CDS YP_402048.2 161950157 3796843 complement(335631..336539) 1 NC_007606.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 336539 yajF 3796843 yajF Shigella dysenteriae Sd197 fructokinase YP_402048.2 335631 R 300267 CDS YP_402049.1 82775701 3797480 336664..337575 1 NC_007606.1 Required for efficient pilin antigenic variation; recombination associated protein 337575 rdgC 3797480 rdgC Shigella dysenteriae Sd197 recombination associated protein YP_402049.1 336664 D 300267 CDS YP_402050.1 82775703 3796844 complement(337653..338108) 1 NC_007606.1 hypothetical protein 338108 3796844 SDY_0346 Shigella dysenteriae Sd197 hypothetical protein YP_402050.1 337653 R 300267 CDS YP_402051.1 82775704 3796845 complement(338249..338644) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 338644 3796845 SDY_0347 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402051.1 338249 R 300267 CDS YP_009000637.1 578793097 18262952 complement(338671..338943) 1 NC_007606.1 insertion element iso-IS1N protein InsA 338943 18262952 SDY_0347a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000637.1 338671 R 300267 CDS YP_402053.1 82775706 3796847 340068..340433 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 340433 3796847 SDY_0349 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402053.1 340068 D 300267 CDS YP_402054.2 161950156 3796848 340391..341296 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 341296 3796848 SDY_0350 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402054.2 340391 D 300267 CDS YP_009000638.1 578793098 18262953 341547..341819 1 NC_007606.1 insertion element iso-IS1N protein InsA 341819 18262953 SDY_0350a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000638.1 341547 D 300267 CDS YP_402055.1 82775708 3796849 342028..342243 1 NC_007606.1 insertion element iso-IS1n protein InsB 342243 3796849 SDY_0351 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402055.1 342028 D 300267 CDS YP_402056.1 82775709 3796850 complement(342329..342613) 1 NC_007606.1 Code: S; COG: COG3123; hypothetical protein 342613 yaiE 3796850 yaiE Shigella dysenteriae Sd197 hypothetical protein YP_402056.1 342329 R 300267 CDS YP_402057.1 82775710 3796851 complement(342685..343362) 1 NC_007606.1 regulated by aroR; hypothetical protein 343362 aroM 3796851 aroM Shigella dysenteriae Sd197 hypothetical protein YP_402057.1 342685 R 300267 CDS YP_402058.1 82775711 3796852 complement(343620..343811) 1 NC_007606.1 hypothetical protein 343811 yaiA 3796852 yaiA Shigella dysenteriae Sd197 hypothetical protein YP_402058.1 343620 R 300267 CDS YP_402059.1 82775712 3796853 complement(343861..344385) 1 NC_007606.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 344385 aroL 3796853 aroL Shigella dysenteriae Sd197 shikimate kinase YP_402059.1 343861 R 300267 CDS YP_402060.2 161950155 3796855 complement(344568..345026) 1 NC_007606.1 Code: S; COG: COG1671; hypothetical protein 345026 yaiI 3796855 yaiI Shigella dysenteriae Sd197 hypothetical protein YP_402060.2 344568 R 300267 CDS YP_402061.1 82775713 3796854 345146..345955 1 NC_007606.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 345955 proC 3796854 proC Shigella dysenteriae Sd197 pyrroline-5-carboxylate reductase YP_402061.1 345146 D 300267 CDS YP_402062.1 82775715 3796856 complement(345972..347087) 1 NC_007606.1 ''catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis''; diguanylate cyclase AdrA 347087 adrA 3796856 adrA Shigella dysenteriae Sd197 diguanylate cyclase AdrA YP_402062.1 345972 R 300267 CDS YP_402063.1 82775716 3796857 complement(347269..347982) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 347982 3796857 SDY_0359 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402063.1 347269 R 300267 CDS YP_402064.1 82775717 3796858 complement(348519..348794) 1 NC_007606.1 induced by phosphate starvation 348794 psiF 3796858 psiF Shigella dysenteriae Sd197 induced by phosphate starvation YP_402064.1 348519 R 300267 CDS YP_009000639.1 578793099 18262954 350377..350649 1 NC_007606.1 insertion element iso-IS1N protein InsA 350649 18262954 SDY_0360a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000639.1 350377 D 300267 CDS YP_402065.1 82775718 3796860 350676..351071 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 351071 3796860 SDY_0362 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402065.1 350676 D 300267 CDS YP_402066.1 82775719 3796861 complement(351184..351444) 1 NC_007606.1 hypothetical protein 351444 yaiB 3796861 yaiB Shigella dysenteriae Sd197 hypothetical protein YP_402066.1 351184 R 300267 CDS YP_402067.1 82775720 3799557 complement(351496..351891) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 351891 3799557 SDY_0364 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402067.1 351496 R 300267 CDS YP_009000640.1 578793100 18262955 complement(351918..352190) 1 NC_007606.1 insertion element iso-IS1N protein InsA 352190 18262955 SDY_0365a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000640.1 351918 R 300267 CDS YP_402068.1 82775721 3799558 352680..353774 1 NC_007606.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 353774 ddl 3799558 ddl Shigella dysenteriae Sd197 D-alanyl-alanine synthetase A YP_402068.1 352680 D 300267 CDS YP_402069.1 82775722 3799559 complement(353798..354142) 1 NC_007606.1 hypothetical protein 354142 3799559 SDY_0366 Shigella dysenteriae Sd197 hypothetical protein YP_402069.1 353798 R 300267 CDS YP_402070.1 82775723 3799560 354270..354578 1 NC_007606.1 hypothetical protein 354578 3799560 SDY_0367 Shigella dysenteriae Sd197 hypothetical protein YP_402070.1 354270 D 300267 CDS YP_402071.1 82775724 3799561 complement(354637..355731) 1 NC_007606.1 hypothetical protein 355731 yaiW 3799561 yaiW Shigella dysenteriae Sd197 hypothetical protein YP_402071.1 354637 R 300267 CDS YP_402072.1 82775725 3799562 complement(355744..356964) 1 NC_007606.1 possible envelop protein; ''in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope''; transporter 356964 sbmA 3799562 sbmA Shigella dysenteriae Sd197 transporter YP_402072.1 355744 R 300267 CDS YP_402073.1 82775726 3799563 357316..358485 1 NC_007606.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 358485 yaiH 3799563 yaiH Shigella dysenteriae Sd197 beta-lactam binding protein AmpH YP_402073.1 357316 D 300267 CDS YP_402074.1 82775727 3799564 complement(358474..358707) 1 NC_007606.1 hypothetical protein 358707 3799564 SDY_0371 Shigella dysenteriae Sd197 hypothetical protein YP_402074.1 358474 R 300267 CDS YP_009000641.1 578793101 18262956 358871..359143 1 NC_007606.1 insertion element iso-IS1N protein InsA 359143 18262956 SDY_0371a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000641.1 358871 D 300267 CDS YP_402075.1 82775728 3799565 359170..359565 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 359565 3799565 SDY_0372 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402075.1 359170 D 300267 CDS YP_402076.1 82775729 3799566 complement(359575..359916) 1 NC_007606.1 hypothetical protein 359916 yaiV 3799566 yaiV Shigella dysenteriae Sd197 hypothetical protein YP_402076.1 359575 R 300267 CDS YP_402077.1 82775730 3799567 complement(360005..360382) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 360382 insB 3799567 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402077.1 360005 R 300267 CDS YP_402078.1 82775731 3799568 complement(360427..360702) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 360702 insA 3799568 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402078.1 360427 R 300267 CDS YP_009000642.1 578793102 18262957 361181..361453 1 NC_007606.1 insertion element iso-IS1N protein InsA 361453 18262957 SDY_0375a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000642.1 361181 D 300267 CDS YP_402079.2 161950154 3799570 361480..361875 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 361875 3799570 SDY_0377 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402079.2 361480 D 300267 CDS YP_402081.1 82775734 3799572 complement(365263..366345) 1 NC_007606.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 366345 lacI 3799572 lacI Shigella dysenteriae Sd197 lac repressor YP_402081.1 365263 R 300267 CDS YP_402082.1 82775735 3799573 complement(366382..366864) 1 NC_007606.1 hypothetical protein 366864 3799573 SDY_0380 Shigella dysenteriae Sd197 hypothetical protein YP_402082.1 366382 R 300267 CDS YP_402083.1 82775736 3799574 366880..367182 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 367182 3799574 SDY_0381 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402083.1 366880 D 300267 CDS YP_402084.1 82775737 3799575 367323..368036 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 368036 3799575 SDY_0382 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402084.1 367323 D 300267 CDS YP_402085.1 82775738 3799576 368064..368510 1 NC_007606.1 Code: R; COG: COG0561; hypothetical protein 368510 cof 3799576 cof Shigella dysenteriae Sd197 hypothetical protein YP_402085.1 368064 D 300267 CDS YP_402086.1 82775739 3799577 368576..369121 1 NC_007606.1 Code: K; COG: COG1522; LRP-like transcriptional regulator 369121 ybaO 3799577 ybaO Shigella dysenteriae Sd197 LRP-like transcriptional regulator YP_402086.1 368576 D 300267 CDS YP_402087.1 82775740 3799578 369151..370923 1 NC_007606.1 Code: V; COG: COG1132; multidrug transporter membrane protein/ATP-binding protein 370923 mdlA 3799578 mdlA Shigella dysenteriae Sd197 multidrug transporter membrane protein/ATP-binding protein YP_402087.1 369151 D 300267 CDS YP_402088.1 82775741 3799579 370916..372697 1 NC_007606.1 Code: V; COG: COG1132; multidrug transporter membrane protein/ATP-binding protein 372697 mdlB 3799579 mdlB Shigella dysenteriae Sd197 multidrug transporter membrane protein/ATP-binding protein YP_402088.1 370916 D 300267 CDS YP_402089.1 82775742 3799580 372878..373216 1 NC_007606.1 ''indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.''; nitrogen regulatory protein P-II 2 373216 glnK 3799580 glnK Shigella dysenteriae Sd197 nitrogen regulatory protein P-II 2 YP_402089.1 372878 D 300267 CDS YP_402090.1 82775743 3799581 373246..374532 1 NC_007606.1 Code: P; COG: COG0004; ammonium transporter 374532 amtB 3799581 amtB Shigella dysenteriae Sd197 ammonium transporter YP_402090.1 373246 D 300267 CDS YP_402091.1 82775744 3799582 complement(374581..375441) 1 NC_007606.1 Code: I; COG: COG1946; acyl-CoA thioesterase 375441 tesB 3799582 tesB Shigella dysenteriae Sd197 acyl-CoA thioesterase YP_402091.1 374581 R 300267 CDS YP_402092.1 82775745 3799584 complement(376262..376651) 1 NC_007606.1 Code: L; COG: COG3695; hypothetical protein 376651 ybaZ 3799584 ybaZ Shigella dysenteriae Sd197 hypothetical protein YP_402092.1 376262 R 300267 CDS YP_402093.1 82775746 3799585 376952..377305 1 NC_007606.1 Code: S; COG: COG5507; hypothetical protein 377305 ybaA 3799585 ybaA Shigella dysenteriae Sd197 hypothetical protein YP_402093.1 376952 D 300267 CDS YP_402094.1 82775747 3799586 complement(377347..378660) 1 NC_007606.1 Code: T; COG: COG4943; hypothetical protein 378660 ylaB 3799586 ylaB Shigella dysenteriae Sd197 hypothetical protein YP_402094.1 377347 R 300267 CDS YP_402095.1 82775748 3799587 378730..379005 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 379005 insA 3799587 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402095.1 378730 D 300267 CDS YP_402096.1 82775749 3799588 complement(379362..380921) 1 NC_007606.1 Code: R; COG: COG3960; glyoxylate carboligase 380921 gcl 3799588 gcl Shigella dysenteriae Sd197 glyoxylate carboligase YP_402096.1 379362 R 300267 CDS YP_402097.1 82775750 3799589 complement(381011..381826) 1 NC_007606.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 381826 ybbU 3799589 ybbU Shigella dysenteriae Sd197 DNA-binding transcriptional repressor AllR YP_402097.1 381011 R 300267 CDS YP_402098.1 82775751 3799590 complement(381904..382386) 1 NC_007606.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 382386 ybbT 3799590 ybbT Shigella dysenteriae Sd197 ureidoglycolate hydrolase YP_402098.1 381904 R 300267 CDS YP_402099.1 82775752 3799591 382615..383541 1 NC_007606.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 383541 ybbS 3799591 ybbS Shigella dysenteriae Sd197 DNA-binding transcriptional activator AllS YP_402099.1 382615 D 300267 CDS YP_402100.1 82775753 3799592 383610..384704 1 NC_007606.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 384704 ybbB 3799592 ybbB Shigella dysenteriae Sd197 tRNA 2-selenouridine synthase YP_402100.1 383610 D 300267 CDS YP_402101.1 82775754 3799593 384784..385191 1 NC_007606.1 hypothetical protein 385191 3799593 SDY_0400 Shigella dysenteriae Sd197 hypothetical protein YP_402101.1 384784 D 300267 CDS YP_402102.1 82775755 3799594 385896..386171 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 386171 insA 3799594 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402102.1 385896 D 300267 CDS YP_402103.1 82775756 3799595 386216..386593 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 386593 insB 3799595 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402103.1 386216 D 300267 CDS YP_402104.1 82775758 3796152 complement(389100..389786) 1 NC_007606.1 Code: Q; COG: COG4181; ABC transporter ATP-binding protein YbbA 389786 ybbA 3796152 ybbA Shigella dysenteriae Sd197 ABC transporter ATP-binding protein YbbA YP_402104.1 389100 R 300267 CDS YP_402105.1 82775757 3796151 389754..390380 1 NC_007606.1 also functions as protease I; Code: E; COG: COG2755; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 390380 tesA 3796151 tesA Shigella dysenteriae Sd197 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 YP_402105.1 389754 D 300267 CDS YP_402106.1 82775759 3796153 390370..391179 1 NC_007606.1 Code: IQR; COG: COG1028; short chain dehydrogenase 391179 ybbO 3796153 ybbO Shigella dysenteriae Sd197 short chain dehydrogenase YP_402106.1 390370 D 300267 CDS YP_402107.1 82775760 3796154 391204..392094 1 NC_007606.1 Code: O; COG: COG3118; thioredoxin-like protein 392094 ybbN 3796154 ybbN Shigella dysenteriae Sd197 thioredoxin-like protein YP_402107.1 391204 D 300267 CDS YP_402108.1 82775761 3796155 complement(392157..392963) 1 NC_007606.1 Code: R; COG: COG0390; metal resistance protein 392963 ybbM 3796155 ybbM Shigella dysenteriae Sd197 metal resistance protein YP_402108.1 392157 R 300267 CDS YP_402109.1 82775762 3796156 complement(392923..393600) 1 NC_007606.1 Code: R; COG: COG4619; ABC transporter ATP-binding protein YbbL 393600 ybbL 3796156 ybbL Shigella dysenteriae Sd197 ABC transporter ATP-binding protein YbbL YP_402109.1 392923 R 300267 CDS YP_402110.1 82775763 3796157 393746..394663 1 NC_007606.1 Code: O; COG: COG0330; protease 394663 ybbK 3796157 ybbK Shigella dysenteriae Sd197 protease YP_402110.1 393746 D 300267 CDS YP_402111.1 82775764 3796158 394660..395118 1 NC_007606.1 Code: OU; COG: COG1585; hypothetical protein 395118 ybbJ 3796158 ybbJ Shigella dysenteriae Sd197 hypothetical protein YP_402111.1 394660 D 300267 CDS YP_402112.1 82775765 3796159 complement(395198..395560) 1 NC_007606.1 hypothetical protein 395560 3796159 SDY_0412 Shigella dysenteriae Sd197 hypothetical protein YP_402112.1 395198 R 300267 CDS YP_009000643.1 578793103 18262958 396353..396625 1 NC_007606.1 insertion element iso-IS1N protein InsA 396625 18262958 SDY_0413a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000643.1 396353 D 300267 CDS YP_402114.1 82775767 3796161 396652..397047 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 397047 3796161 SDY_0414 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402114.1 396652 D 300267 CDS YP_402115.1 82775768 3796162 complement(397196..397603) 1 NC_007606.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 397603 ybbI 3796162 ybbI Shigella dysenteriae Sd197 DNA-binding transcriptional regulator CueR YP_402115.1 397196 R 300267 CDS YP_402116.1 82775769 3796163 complement(397600..398775) 1 NC_007606.1 Code: M; COG: COG0845; membrane spanning export protein 398775 3796163 SDY_0416 Shigella dysenteriae Sd197 membrane spanning export protein YP_402116.1 397600 R 300267 CDS YP_402117.1 82775770 3796164 complement(398772..400298) 1 NC_007606.1 Code: V; COG: COG2274; cytoplasmic membrane export protein 400298 3796164 SDY_0417 Shigella dysenteriae Sd197 cytoplasmic membrane export protein YP_402117.1 398772 R 300267 CDS YP_009000644.1 578793104 18262959 415932..416204 1 NC_007606.1 insertion element iso-IS1N protein InsA 416204 18262959 SDY_0427a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000644.1 415932 D 300267 CDS YP_402127.1 82775780 3799097 416231..416626 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 416626 3799097 SDY_0427 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402127.1 416231 D 300267 CDS YP_402130.1 82775783 3799100 417654..417929 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 417929 insA 3799100 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402130.1 417654 D 300267 CDS YP_009000645.1 578793105 3799101 417974..418351 1 NC_007606.1 insertion element iso-IS1d protein InsB 418351 insB 3799101 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_009000645.1 417974 D 300267 CDS YP_402132.1 82775785 3799102 complement(418512..419804) 1 NC_007606.1 Code: E; COG: COG0531; amino acid/amine transport protein 419804 ybaT 3799102 ybaT Shigella dysenteriae Sd197 amino acid/amine transport protein YP_402132.1 418512 R 300267 CDS YP_402133.1 82775786 3799104 421002..423506 1 NC_007606.1 Code: P; COG: COG2217; copper exporting ATPase 423506 copA 3799104 copA Shigella dysenteriae Sd197 copper exporting ATPase YP_402133.1 421002 D 300267 CDS YP_402134.1 82775787 3799105 complement(423620..424015) 1 NC_007606.1 Code: R; COG: COG3093; hypothetical protein 424015 ybaQ 3799105 ybaQ Shigella dysenteriae Sd197 hypothetical protein YP_402134.1 423620 R 300267 CDS YP_402135.1 82775788 3799106 424099..424893 1 NC_007606.1 Code: S; COG: COG3735; ligase 424893 ybaP 3799106 ybaP Shigella dysenteriae Sd197 ligase YP_402135.1 424099 D 300267 CDS YP_402136.1 82775789 3799107 425097..425576 1 NC_007606.1 Code: S; COG: COG2606; hypothetical protein 425576 ybaK 3799107 ybaK Shigella dysenteriae Sd197 hypothetical protein YP_402136.1 425097 D 300267 CDS YP_402137.1 82775790 3799108 complement(425613..427265) 1 NC_007606.1 5'-nucleotidase; ''catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides''; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 427265 ushA 3799108 ushA Shigella dysenteriae Sd197 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic YP_402137.1 425613 R 300267 CDS YP_402138.1 82775791 3799110 complement(427709..429055) 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 429055 3799110 SDY_0440 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_402138.1 427709 R 300267 CDS YP_402139.1 82775792 3799111 430380..432056 1 NC_007606.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 432056 ybaL 3799111 ybaL Shigella dysenteriae Sd197 cation:proton antiport protein YP_402139.1 430380 D 300267 CDS YP_402140.1 82775793 3798060 complement(432190..433494) 1 NC_007606.1 Code: G; COG: COG0524; inosine-guanosine kinase 433494 gsk 3798060 gsk Shigella dysenteriae Sd197 inosine-guanosine kinase YP_402140.1 432190 R 300267 CDS YP_402141.1 82775794 3798062 complement(434602..435564) 1 NC_007606.1 final enzyme of heme biosynthesis; protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 435564 hemH 3798062 hemH Shigella dysenteriae Sd197 ferrochelatase YP_402141.1 434602 R 300267 CDS YP_402142.1 82775795 3798063 complement(435696..436340) 1 NC_007606.1 adenylate kinase activity; pleiotropic effects on glycerol-3-phosphate acyltransferase activity; essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 436340 adk 3798063 adk Shigella dysenteriae Sd197 adenylate kinase YP_402142.1 435696 R 300267 CDS YP_402143.1 82775796 3798064 complement(436521..438395) 1 NC_007606.1 heat shock protein C 62.5; molecular chaperone; heat shock protein 90 438395 htpG 3798064 htpG Shigella dysenteriae Sd197 heat shock protein 90 YP_402143.1 436521 R 300267 CDS YP_402144.1 82775797 3798065 complement(438505..439110) 1 NC_007606.1 ''involved in a recombinational process of DNA repair, independent of the recBC complex''; recombination protein RecR 439110 recR 3798065 recR Shigella dysenteriae Sd197 recombination protein RecR YP_402144.1 438505 R 300267 CDS YP_402145.1 82775798 3798066 complement(439110..439439) 1 NC_007606.1 Code: S; COG: COG0718; hypothetical protein 439439 ybaB 3798066 ybaB Shigella dysenteriae Sd197 hypothetical protein YP_402145.1 439110 R 300267 CDS YP_402146.1 82775799 3798067 complement(439492..441423) 1 NC_007606.1 DNA elongation factor III; ''catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA''; DNA polymerase III subunits gamma and tau 441423 dnaX 3798067 dnaX Shigella dysenteriae Sd197 DNA polymerase III subunits gamma and tau YP_402146.1 439492 R 300267 CDS YP_402147.1 82775800 3798068 complement(441552..442103) 1 NC_007606.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 442103 apt 3798068 apt Shigella dysenteriae Sd197 adenine phosphoribosyltransferase YP_402147.1 441552 R 300267 CDS YP_402148.1 82775801 3798069 complement(442256..442633) 1 NC_007606.1 Code: S; COG: COG2832; hypothetical protein 442633 ybaN 3798069 ybaN Shigella dysenteriae Sd197 hypothetical protein YP_402148.1 442256 R 300267 CDS YP_402149.1 82775802 3798070 442703..443230 1 NC_007606.1 ''PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks''; primosomal replication protein N'' 443230 priC 3798070 priC Shigella dysenteriae Sd197 primosomal replication protein N'' YP_402149.1 442703 D 300267 CDS YP_402150.1 82775803 3798071 443244..443408 1 NC_007606.1 hypothetical protein 443408 ybaM 3798071 ybaM Shigella dysenteriae Sd197 hypothetical protein YP_402150.1 443244 D 300267 CDS YP_402151.1 82775804 3798072 complement(443447..446809) 1 NC_007606.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 446809 aefA 3798072 aefA Shigella dysenteriae Sd197 potassium efflux protein KefA YP_402151.1 443447 R 300267 CDS YP_402152.1 82775805 3798073 complement(446937..447584) 1 NC_007606.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 447584 acrR 3798073 acrR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor AcrR YP_402152.1 446937 R 300267 CDS YP_402153.1 82775806 3798074 447726..448919 1 NC_007606.1 Code: M; COG: COG0845; acridine efflux pump 448919 acrA 3798074 acrA Shigella dysenteriae Sd197 acridine efflux pump YP_402153.1 447726 D 300267 CDS YP_402154.1 82775807 3798075 448942..452091 1 NC_007606.1 Code: V; COG: COG0841; acridine efflux pump 452091 acrB 3798075 acrB Shigella dysenteriae Sd197 acridine efflux pump YP_402154.1 448942 D 300267 CDS YP_402155.1 82775808 3798076 452637..453011 1 NC_007606.1 hypothetical protein 453011 ybaJ 3798076 ybaJ Shigella dysenteriae Sd197 hypothetical protein YP_402155.1 452637 D 300267 CDS YP_402156.1 82775809 3798077 453037..453255 1 NC_007606.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins; hemolysin expression-modulating protein 453255 hha 3798077 hha Shigella dysenteriae Sd197 hemolysin expression-modulating protein YP_402156.1 453037 D 300267 CDS YP_402157.1 82775810 3798078 453427..453978 1 NC_007606.1 Code: R; COG: COG0110; maltose O-acetyltransferase 453978 ylaD 3798078 ylaD Shigella dysenteriae Sd197 maltose O-acetyltransferase YP_402157.1 453427 D 300267 CDS YP_402158.1 82775811 3798079 454055..454564 1 NC_007606.1 hypothetical protein 454564 ylaC 3798079 ylaC Shigella dysenteriae Sd197 hypothetical protein YP_402158.1 454055 D 300267 CDS YP_402159.1 82775812 3796170 454728..454928 1 NC_007606.1 hypothetical protein 454928 3796170 SDY_0462 Shigella dysenteriae Sd197 hypothetical protein YP_402159.1 454728 D 300267 CDS YP_402160.1 82775813 3796171 455017..455382 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 455382 3796171 SDY_0463 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402160.1 455017 D 300267 CDS YP_402161.2 161950153 3796172 455340..456245 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 456245 3796172 SDY_0464 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402161.2 455340 D 300267 CDS YP_402162.1 82775815 3796173 complement(456311..456688) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 456688 insB 3796173 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402162.1 456311 R 300267 CDS YP_402163.1 82775816 3796174 complement(456733..457008) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 457008 insA 3796174 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402163.1 456733 R 300267 CDS YP_402164.1 82775817 3796175 457321..457623 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 457623 3796175 SDY_0467 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402164.1 457321 D 300267 CDS YP_009000646.1 578793106 18262960 458669..458941 1 NC_007606.1 insertion element iso-IS1N protein InsA 458941 18262960 SDY_0470a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000646.1 458669 D 300267 CDS YP_402167.1 82775820 3796178 458968..459363 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 459363 3796178 SDY_0470 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402167.1 458968 D 300267 CDS YP_402169.1 82775822 3796181 complement(460593..461846) 1 NC_007606.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 461846 proA 3796181 proA Shigella dysenteriae Sd197 gamma-glutamyl phosphate reductase YP_402169.1 460593 R 300267 CDS YP_402170.1 82775823 3796182 complement(461858..462961) 1 NC_007606.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 462961 proB 3796182 proB Shigella dysenteriae Sd197 gamma-glutamyl kinase YP_402170.1 461858 R 300267 CDS YP_402171.1 82775824 3796183 463189..463464 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 463464 insA 3796183 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402171.1 463189 D 300267 CDS YP_402172.1 82775825 3796184 463509..463886 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 463886 insB 3796184 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402172.1 463509 D 300267 CDS YP_402173.1 82775826 3796185 complement(463961..464362) 1 NC_007606.1 transcriptional regulator of cryptic csgA gene for curli surface fibers; involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 464362 crl 3796185 crl Shigella dysenteriae Sd197 DNA-binding transcriptional regulator Crl YP_402173.1 463961 R 300267 CDS YP_402174.1 82775827 3796186 complement(464420..465664) 1 NC_007606.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 465664 frsA 3796186 frsA Shigella dysenteriae Sd197 fermentation/respiration switch protein YP_402174.1 464420 R 300267 CDS YP_402175.1 82775828 3796187 complement(465756..466214) 1 NC_007606.1 ''catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively''; xanthine-guanine phosphoribosyltransferase 466214 gpt 3796187 gpt Shigella dysenteriae Sd197 xanthine-guanine phosphoribosyltransferase YP_402175.1 465756 R 300267 CDS YP_402176.1 82775829 3796079 466475..467932 1 NC_007606.1 peptidase D; Code: E; COG: COG2195; aminoacyl-histidine dipeptidase 467932 pepD 3796079 pepD Shigella dysenteriae Sd197 aminoacyl-histidine dipeptidase YP_402176.1 466475 D 300267 CDS YP_402177.1 82775830 3796080 complement(467989..468489) 1 NC_007606.1 peptide chain release factor-like protein 468489 prfH 3796080 prfH Shigella dysenteriae Sd197 peptide chain release factor-like protein YP_402177.1 467989 R 300267 CDS YP_402178.1 82775831 3796081 complement(468458..468724) 1 NC_007606.1 Code: S; COG: COG1690; hypothetical protein 468724 3796081 SDY_0482 Shigella dysenteriae Sd197 hypothetical protein YP_402178.1 468458 R 300267 CDS YP_402179.1 82775832 3796082 complement(469480..470535) 1 NC_007606.1 tRNA synthetase; involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 470535 dinP 3796082 dinP Shigella dysenteriae Sd197 DNA polymerase IV YP_402179.1 469480 R 300267 CDS YP_402180.1 82775833 3796083 complement(470606..471385) 1 NC_007606.1 Code: N; COG: COG1360; hypothetical protein 471385 mbhA 3796083 mbhA Shigella dysenteriae Sd197 hypothetical protein YP_402180.1 470606 R 300267 CDS YP_402181.1 82775834 3796084 complement(471532..472275) 1 NC_007606.1 Code: N; COG: COG1291; flagellar motor transmembrane channel protein 472275 3796084 SDY_0485 Shigella dysenteriae Sd197 flagellar motor transmembrane channel protein YP_402181.1 471532 R 300267 CDS YP_009000647.1 578793107 18262961 472198..472470 1 NC_007606.1 insertion element iso-IS1N protein InsA 472470 18262961 SDY_0485a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000647.1 472198 D 300267 CDS YP_402182.1 82775835 3796085 472497..472892 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 472892 3796085 SDY_0486 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402182.1 472497 D 300267 CDS YP_402183.1 82775836 3796086 473162..473449 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 473449 insA 3796086 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_402183.1 473162 D 300267 CDS YP_402184.1 82775837 3796087 473945..475327 1 NC_007606.1 hypothetical protein 475327 3796087 SDY_0488 Shigella dysenteriae Sd197 hypothetical protein YP_402184.1 473945 D 300267 CDS YP_402185.1 82775838 3796088 475429..476805 1 NC_007606.1 Code: E; COG: COG1113; phenylalanine transporter 476805 pheP 3796088 pheP Shigella dysenteriae Sd197 phenylalanine transporter YP_402185.1 475429 D 300267 CDS YP_402186.1 82775839 3796089 complement(476873..478120) 1 NC_007606.1 Code: M; COG: COG0668; transporter 478120 ybdG 3796089 ybdG Shigella dysenteriae Sd197 transporter YP_402186.1 476873 R 300267 CDS YP_402187.1 82775840 3796090 complement(478228..478881) 1 NC_007606.1 ''catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive''; dihydropteridine reductase 478881 nfnB 3796090 nfnB Shigella dysenteriae Sd197 dihydropteridine reductase YP_402187.1 478228 R 300267 CDS YP_402188.1 82775841 3796091 complement(478975..479343) 1 NC_007606.1 Code: S; COG: COG2315; hypothetical protein 479343 ybdF 3796091 ybdF Shigella dysenteriae Sd197 hypothetical protein YP_402188.1 478975 R 300267 CDS YP_402189.1 82775842 3796092 complement(479408..479656) 1 NC_007606.1 hypothetical protein 479656 ybdJ 3796092 ybdJ Shigella dysenteriae Sd197 hypothetical protein YP_402189.1 479408 R 300267 CDS YP_402190.1 82775843 3796093 complement(479722..480840) 1 NC_007606.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 480840 ybdK 3796093 ybdK Shigella dysenteriae Sd197 carboxylate-amine ligase YP_402190.1 479722 R 300267 CDS YP_009000648.1 578793108 18262962 481279..481431 1 NC_007606.1 toxic polypeptide 481431 18262962 SDY_0495a Shigella dysenteriae Sd197 toxic polypeptide YP_009000648.1 481279 D 300267 CDS YP_402191.2 161950152 3796094 complement(481764..482669) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 482669 3796094 SDY_0495 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402191.2 481764 R 300267 CDS YP_402192.1 82775845 3796095 complement(482627..482992) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 482992 3796095 SDY_0496 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402192.1 482627 R 300267 CDS YP_402193.1 82775846 3796096 483003..483995 1 NC_007606.1 hypothetical protein 483995 3796096 SDY_0497 Shigella dysenteriae Sd197 hypothetical protein YP_402193.1 483003 D 300267 CDS YP_402194.1 82775847 3796097 484134..484817 1 NC_007606.1 hypothetical protein 484817 3796097 SDY_0498 Shigella dysenteriae Sd197 hypothetical protein YP_402194.1 484134 D 300267 CDS YP_402195.1 82775848 3796098 484868..485143 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 485143 insA 3796098 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402195.1 484868 D 300267 CDS YP_402196.1 82775849 3797427 485188..485565 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 485565 insB 3797427 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402196.1 485188 D 300267 CDS YP_402197.1 82775850 3797428 485847..486854 1 NC_007606.1 porphobilinogen synthase; catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 486854 hemB 3797428 hemB Shigella dysenteriae Sd197 delta-aminolevulinic acid dehydratase YP_402197.1 485847 D 300267 CDS YP_402198.1 82775851 3797429 complement(486961..487812) 1 NC_007606.1 2-oxoglutarate-dependent; catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 487812 tauD 3797429 tauD Shigella dysenteriae Sd197 taurine dioxygenase YP_402198.1 486961 R 300267 CDS YP_402199.1 82775852 3797430 complement(487809..488636) 1 NC_007606.1 Code: P; COG: COG0600; taurine transporter subunit 488636 tauC 3797430 tauC Shigella dysenteriae Sd197 taurine transporter subunit YP_402199.1 487809 R 300267 CDS YP_402200.1 82775853 3797431 complement(488633..489400) 1 NC_007606.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine ABC transporter ATP-binding protein 489400 tauB 3797431 tauB Shigella dysenteriae Sd197 taurine ABC transporter ATP-binding protein YP_402200.1 488633 R 300267 CDS YP_402201.1 82775854 3797432 complement(489413..490375) 1 NC_007606.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 490375 tauA 3797432 tauA Shigella dysenteriae Sd197 taurine transporter substrate binding subunit YP_402201.1 489413 R 300267 CDS YP_402202.1 82775855 3797433 490678..491307 1 NC_007606.1 hexosephosphate transport; Code: TK; COG: COG2197; response regulator 491307 3797433 SDY_0506 Shigella dysenteriae Sd197 response regulator YP_402202.1 490678 D 300267 CDS YP_402206.1 82775859 3797437 complement(493226..493591) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 493591 3797437 SDY_0510 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402206.1 493226 R 300267 CDS YP_009000649.1 578793109 18262963 493717..493869 1 NC_007606.1 toxic polypeptide 493869 18262963 SDY_0510a Shigella dysenteriae Sd197 toxic polypeptide YP_009000649.1 493717 D 300267 CDS YP_402207.1 82775860 3797438 complement(493991..494620) 1 NC_007606.1 Code: Q; COG: COG2977; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 494620 entD 3797438 entD Shigella dysenteriae Sd197 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_402207.1 493991 R 300267 CDS YP_402208.1 82775861 3797439 complement(494786..497026) 1 NC_007606.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 497026 fepA 3797439 fepA Shigella dysenteriae Sd197 outer membrane receptor FepA YP_402208.1 494786 R 300267 CDS YP_402209.1 82775862 3797440 497347..498471 1 NC_007606.1 Code: P; COG: COG2382; enterobactin/ferric enterobactin esterase 498471 fes 3797440 fes Shigella dysenteriae Sd197 enterobactin/ferric enterobactin esterase YP_402209.1 497347 D 300267 CDS YP_402210.1 82775863 3797441 498474..498692 1 NC_007606.1 Code: S; COG: COG3251; hypothetical protein 498692 ybdZ 3797441 ybdZ Shigella dysenteriae Sd197 hypothetical protein YP_402210.1 498474 D 300267 CDS YP_402211.1 82775864 3797442 498689..502570 1 NC_007606.1 may be part of enterobactin synthase as component F; ''with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin''; enterobactin synthase subunit F 502570 entF 3797442 entF Shigella dysenteriae Sd197 enterobactin synthase subunit F YP_402211.1 498689 D 300267 CDS YP_009000650.1 578793110 3797443 complement(502790..503167) 1 NC_007606.1 insertion element iso-IS1d protein InsB 503167 insB 3797443 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_009000650.1 502790 R 300267 CDS YP_402213.1 82775866 3797444 complement(503212..503487) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 503487 insA 3797444 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402213.1 503212 R 300267 CDS YP_402214.1 82775867 3797445 503562..504695 1 NC_007606.1 enterochelin transport; part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 504695 fepE 3797445 fepE Shigella dysenteriae Sd197 ferric enterobactin transport protein FepE YP_402214.1 503562 D 300267 CDS YP_402215.1 82775868 3799884 complement(504692..505507) 1 NC_007606.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter ATP-binding protein 505507 fepC 3799884 fepC Shigella dysenteriae Sd197 iron-enterobactin ABC transporter ATP-binding protein YP_402215.1 504692 R 300267 CDS YP_402216.1 82775869 3799885 complement(505504..506496) 1 NC_007606.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter permease 506496 fepG 3799885 fepG Shigella dysenteriae Sd197 iron-enterobactin ABC transporter permease YP_402216.1 505504 R 300267 CDS YP_402217.1 82775870 3799886 complement(506493..507497) 1 NC_007606.1 enterochelin transport; with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter permease 507497 fepD 3799886 fepD Shigella dysenteriae Sd197 iron-enterobactin ABC transporter permease YP_402217.1 506493 R 300267 CDS YP_402218.1 82775871 3799887 507608..508858 1 NC_007606.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 508858 ybdA 3799887 ybdA Shigella dysenteriae Sd197 enterobactin exporter EntS YP_402218.1 507608 D 300267 CDS YP_402219.1 82775872 3799888 complement(508939..509904) 1 NC_007606.1 enterochelin binding protein; periplasmic component; with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter substrate-binding protein 509904 fepB 3799888 fepB Shigella dysenteriae Sd197 iron-enterobactin ABC transporter substrate-binding protein YP_402219.1 508939 R 300267 CDS YP_402220.1 82775873 3799889 510093..511268 1 NC_007606.1 enterochelin biosynthesis; Code: HQ; COG: COG1169; isochorismate hydroxymutase 511268 entC 3799889 entC Shigella dysenteriae Sd197 isochorismate hydroxymutase YP_402220.1 510093 D 300267 CDS YP_402221.1 82775874 3799890 511278..512888 1 NC_007606.1 ''bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate''; enterobactin synthase subunit E 512888 entE 3799890 entE Shigella dysenteriae Sd197 enterobactin synthase subunit E YP_402221.1 511278 D 300267 CDS YP_402222.1 82775875 3799891 512902..513759 1 NC_007606.1 isochroismatase; Code: Q; COG: COG1535; 2,3-dihydro-2,3-dihydroxybenzoate synthetase 513759 entB 3799891 entB Shigella dysenteriae Sd197 2,3-dihydro-2,3-dihydroxybenzoate synthetase YP_402222.1 512902 D 300267 CDS YP_402223.1 82775876 3799892 513759..514505 1 NC_007606.1 enterochelin biosynthesis; ''catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin''; 2,3-dihydroxybenzoate-2,3-dehydrogenase 514505 entA 3799892 entA Shigella dysenteriae Sd197 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_402223.1 513759 D 300267 CDS YP_402224.1 82775877 3799893 514508..514921 1 NC_007606.1 Code: Q; COG: COG2050; hypothetical protein 514921 ybdB 3799893 ybdB Shigella dysenteriae Sd197 hypothetical protein YP_402224.1 514508 D 300267 CDS YP_402225.1 82775878 3799895 517389..517586 1 NC_007606.1 Code: S; COG: COG2879; hypothetical protein 517586 ybdD 3799895 ybdD Shigella dysenteriae Sd197 hypothetical protein YP_402225.1 517389 D 300267 CDS YP_402226.1 82775879 3799896 complement(517596..518684) 1 NC_007606.1 member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein 518684 ybdH 3799896 ybdH Shigella dysenteriae Sd197 hypothetical protein YP_402226.1 517596 R 300267 CDS YP_402229.1 82775882 3799899 complement(520556..521143) 1 NC_007606.1 hypothetical protein 521143 3799899 SDY_0534 Shigella dysenteriae Sd197 hypothetical protein YP_402229.1 520556 R 300267 CDS YP_402230.1 82775883 3799900 521209..521511 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 521511 3799900 SDY_0535 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402230.1 521209 D 300267 CDS YP_402231.1 82775884 3799901 521652..522365 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 522365 3799901 SDY_0536 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402231.1 521652 D 300267 CDS YP_402232.1 82775885 3799902 complement(522390..523043) 1 NC_007606.1 Code: R; COG: COG3969; hypothetical protein 523043 ybdN 3799902 ybdN Shigella dysenteriae Sd197 hypothetical protein YP_402232.1 522390 R 300267 CDS YP_009000651.1 578793111 18262964 523516..523788 1 NC_007606.1 insertion element iso-IS1N protein InsA 523788 18262964 SDY_0537a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000651.1 523516 D 300267 CDS YP_402233.1 82775886 3799903 523815..524210 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 524210 3799903 SDY_0538 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402233.1 523815 D 300267 CDS YP_402234.1 82775887 3797335 525582..526145 1 NC_007606.1 detoxification of hydroperoxides; with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 526145 ahpC 3797335 ahpC Shigella dysenteriae Sd197 alkyl hydroperoxide reductase YP_402234.1 525582 D 300267 CDS YP_402235.1 82775888 3797336 526244..527839 1 NC_007606.1 detoxification of hydroperoxides; Code: O; COG: COG3634; alkyl hydroperoxide reductase 527839 ahpF 3797336 ahpF Shigella dysenteriae Sd197 alkyl hydroperoxide reductase YP_402235.1 526244 D 300267 CDS YP_402236.1 82775889 3797337 complement(527960..528388) 1 NC_007606.1 Code: T; COG: COG0589; hypothetical protein 528388 ybdQ 3797337 ybdQ Shigella dysenteriae Sd197 hypothetical protein YP_402236.1 527960 R 300267 CDS YP_402237.1 82775890 3797338 528601..528876 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 528876 insA 3797338 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402237.1 528601 D 300267 CDS YP_402238.1 82775891 3797339 528921..529298 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 529298 insB 3797339 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402238.1 528921 D 300267 CDS YP_402239.1 82775892 3797340 529510..529782 1 NC_007606.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 529782 pagP 3797340 pagP Shigella dysenteriae Sd197 palmitoyl transferase YP_402239.1 529510 D 300267 CDS YP_402240.1 82775893 3797341 529957..530166 1 NC_007606.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 530166 cspE 3797341 cspE Shigella dysenteriae Sd197 cold shock protein CspE YP_402240.1 529957 D 300267 CDS YP_402241.1 82775894 3797342 complement(530220..530603) 1 NC_007606.1 Code: D; COG: COG0239; hypothetical protein 530603 crcB 3797342 crcB Shigella dysenteriae Sd197 hypothetical protein YP_402241.1 530220 R 300267 CDS YP_402243.1 82775896 3797344 531613..531816 1 NC_007606.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 531816 tatE 3797344 tatE Shigella dysenteriae Sd197 twin arginine translocase E YP_402243.1 531613 D 300267 CDS YP_402244.1 82775897 3797345 complement(531917..532882) 1 NC_007606.1 possible sulfur insertion; catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 532882 lipA 3797345 lipA Shigella dysenteriae Sd197 lipoyl synthase YP_402244.1 531917 R 300267 CDS YP_402245.1 82775898 3797346 complement(533091..534026) 1 NC_007606.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 534026 ybeF 3797346 ybeF Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YP_402245.1 533091 R 300267 CDS YP_402246.2 161950151 3797347 complement(534439..535080) 1 NC_007606.1 lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism; lipoyltransferase 535080 lipB 3797347 lipB Shigella dysenteriae Sd197 lipoyltransferase YP_402246.2 534439 R 300267 CDS YP_402247.1 82775900 3797348 complement(535180..535443) 1 NC_007606.1 Code: S; COG: COG2921; hypothetical protein 535443 ybeD 3797348 ybeD Shigella dysenteriae Sd197 hypothetical protein YP_402247.1 535180 R 300267 CDS YP_402248.1 82775901 3797349 complement(535553..536764) 1 NC_007606.1 penicillin-binding protein 5; penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 536764 dacA 3797349 dacA Shigella dysenteriae Sd197 D-alanyl-D-alanine carboxypeptidase YP_402248.1 535553 R 300267 CDS YP_402249.1 82775902 3797350 complement(536904..537992) 1 NC_007606.1 Code: M; COG: COG0797; rare lipoprotein A 537992 rlpA 3797350 rlpA Shigella dysenteriae Sd197 rare lipoprotein A YP_402249.1 536904 R 300267 CDS YP_402250.1 82775903 3797351 complement(538003..539115) 1 NC_007606.1 sensitivity to radiation and drugs; Code: D; COG: COG0772; cell wall shape-determining protein 539115 mrdB 3797351 mrdB Shigella dysenteriae Sd197 cell wall shape-determining protein YP_402250.1 538003 R 300267 CDS YP_402251.1 82775904 3797352 complement(539118..541019) 1 NC_007606.1 cell elongation, e phase; peptidoglycan synthetase; Code: M; COG: COG0768; penicillin-binding protein 2 541019 mrdA 3797352 mrdA Shigella dysenteriae Sd197 penicillin-binding protein 2 YP_402251.1 539118 R 300267 CDS YP_402252.1 82775905 3799672 complement(541050..541517) 1 NC_007606.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 541517 ybeA 3799672 ybeA Shigella dysenteriae Sd197 rRNA large subunit methyltransferase YP_402252.1 541050 R 300267 CDS YP_402253.2 578793112 3799673 complement(541521..541838) 1 NC_007606.1 Code: S; COG: COG0799; hypothetical protein 541838 ybeB 3799673 ybeB Shigella dysenteriae Sd197 hypothetical protein YP_402253.2 541521 R 300267 CDS YP_402254.1 82775907 3799675 complement(542741..543382) 1 NC_007606.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 543382 nadD 3799675 nadD Shigella dysenteriae Sd197 nicotinic acid mononucleotide adenylyltransferase YP_402254.1 542741 R 300267 CDS YP_402255.1 82775908 3799676 complement(543384..544415) 1 NC_007606.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 544415 holA 3799676 holA Shigella dysenteriae Sd197 DNA polymerase III subunit delta YP_402255.1 543384 R 300267 CDS YP_402256.1 82775909 3799677 complement(544415..544996) 1 NC_007606.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 544996 rlpB 3799677 rlpB Shigella dysenteriae Sd197 LPS-assembly lipoprotein RlpB YP_402256.1 544415 R 300267 CDS YP_402257.1 82775910 3799678 complement(545011..547593) 1 NC_007606.1 ''leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase''; leucyl-tRNA synthetase 547593 leuS 3799678 leuS Shigella dysenteriae Sd197 leucyl-tRNA synthetase YP_402257.1 545011 R 300267 CDS YP_402258.1 82775911 3799679 547792..548094 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 548094 3799679 SDY_0565 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402258.1 547792 D 300267 CDS YP_402259.1 82775912 3799680 548121..548960 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 548960 3799680 SDY_0566 Shigella dysenteriae Sd197 insertion sequence element IS911 integrase core domain-containing protein YP_402259.1 548121 D 300267 CDS YP_402260.1 82775913 3799681 549081..549563 1 NC_007606.1 hypothetical protein 549563 ybeL 3799681 ybeL Shigella dysenteriae Sd197 hypothetical protein YP_402260.1 549081 D 300267 CDS YP_402261.1 82775914 3799682 complement(549633..550616) 1 NC_007606.1 Code: R; COG: COG0790; hypothetical protein 550616 ybeQ 3799682 ybeQ Shigella dysenteriae Sd197 hypothetical protein YP_402261.1 549633 R 300267 CDS YP_402262.1 82775915 3799683 complement(550845..551222) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 551222 insB 3799683 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402262.1 550845 R 300267 CDS YP_402263.1 82775916 3799684 complement(551267..551542) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 551542 insA 3799684 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402263.1 551267 R 300267 CDS YP_009000652.1 578793113 18262965 complement(552013..552285) 1 NC_007606.1 insertion element iso-IS1N protein InsA 552285 18262965 SDY_0572a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000652.1 552013 R 300267 CDS YP_402266.1 82775919 3798981 complement(553055..553612) 1 NC_007606.1 bacteriophage protein 553612 3798981 SDY_0577 Shigella dysenteriae Sd197 bacteriophage protein YP_402266.1 553055 R 300267 CDS YP_402267.1 82775920 3798982 complement(553885..554439) 1 NC_007606.1 hypothetical protein 554439 3798982 SDY_0578 Shigella dysenteriae Sd197 hypothetical protein YP_402267.1 553885 R 300267 CDS YP_402268.1 82775921 3798983 complement(554436..554726) 1 NC_007606.1 bacteriophage protein 554726 3798983 SDY_0579 Shigella dysenteriae Sd197 bacteriophage protein YP_402268.1 554436 R 300267 CDS YP_402269.1 82775922 3798984 complement(554933..555538) 1 NC_007606.1 hypothetical protein 555538 3798984 SDY_0580 Shigella dysenteriae Sd197 hypothetical protein YP_402269.1 554933 R 300267 CDS YP_402270.1 82775923 3798985 complement(555577..555864) 1 NC_007606.1 hypothetical protein 555864 3798985 SDY_0581 Shigella dysenteriae Sd197 hypothetical protein YP_402270.1 555577 R 300267 CDS YP_402271.1 82775924 3798986 complement(555930..556175) 1 NC_007606.1 hypothetical protein 556175 3798986 SDY_0582 Shigella dysenteriae Sd197 hypothetical protein YP_402271.1 555930 R 300267 CDS YP_402274.1 82775927 3798989 complement(556949..557251) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 557251 3798989 SDY_0585 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402274.1 556949 R 300267 CDS YP_402275.1 82775928 3798990 557290..557649 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 557649 3798990 SDY_0586 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402275.1 557290 D 300267 CDS YP_402276.1 82775929 3798991 557676..558515 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 558515 3798991 SDY_0587 Shigella dysenteriae Sd197 insertion sequence element IS911 integrase core domain-containing protein YP_402276.1 557676 D 300267 CDS YP_402277.1 82775930 3798992 complement(558682..559356) 1 NC_007606.1 Code: E; COG: COG0765; glutamate/aspartate ABC transporter permease 559356 gltK 3798992 gltK Shigella dysenteriae Sd197 glutamate/aspartate ABC transporter permease YP_402277.1 558682 R 300267 CDS YP_402278.1 82775931 3798994 560013..560315 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 560315 3798994 SDY_0590 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402278.1 560013 D 300267 CDS YP_402279.1 82775932 3798995 560456..561268 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 561268 3798995 SDY_0591 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402279.1 560456 D 300267 CDS YP_402280.1 82775933 3798996 complement(561524..562432) 1 NC_007606.1 Code: ET; COG: COG0834; glutamate/aspartate ABC transporter substrate-binding protein 562432 ybeJ 3798996 ybeJ Shigella dysenteriae Sd197 glutamate/aspartate ABC transporter substrate-binding protein YP_402280.1 561524 R 300267 CDS YP_402281.1 82775934 3796099 complement(562829..564367) 1 NC_007606.1 copper homeostasis protein; inner membrane; Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 564367 lnt 3796099 lnt Shigella dysenteriae Sd197 apolipoprotein N-acyltransferase YP_402281.1 562829 R 300267 CDS YP_402282.1 82775935 3796100 complement(564392..565270) 1 NC_007606.1 Code: P; COG: COG4535; transport protein 565270 ybeX 3796100 ybeX Shigella dysenteriae Sd197 transport protein YP_402282.1 564392 R 300267 CDS YP_402283.1 82775936 3796101 complement(565360..565827) 1 NC_007606.1 Code: R; COG: COG0319; metalloprotease 565827 ybeY 3796101 ybeY Shigella dysenteriae Sd197 metalloprotease YP_402283.1 565360 R 300267 CDS YP_402284.1 82775937 3796102 complement(565824..566903) 1 NC_007606.1 Code: T; COG: COG1702; ATP-binding protein 566903 ybeZ 3796102 ybeZ Shigella dysenteriae Sd197 ATP-binding protein YP_402284.1 565824 R 300267 CDS YP_402285.1 82775938 3796103 complement(567017..568441) 1 NC_007606.1 Code: J; COG: COG0621; hypothetical protein 568441 yleA 3796103 yleA Shigella dysenteriae Sd197 hypothetical protein YP_402285.1 567017 R 300267 CDS YP_402286.1 82775939 3796104 568587..569762 1 NC_007606.1 ''catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q''; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 569762 ubiF 3796104 ubiF Shigella dysenteriae Sd197 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_402286.1 568587 D 300267 CDS YP_402290.1 82775943 3798561 complement(570887..572551) 1 NC_007606.1 ''functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP''; asparagine synthetase B 572551 asnB 3798561 asnB Shigella dysenteriae Sd197 asparagine synthetase B YP_402290.1 570887 R 300267 CDS YP_402291.1 82775944 3798562 complement(572808..573560) 1 NC_007606.1 Code: G; COG: COG0647; UMP phosphatase 573560 nagD 3798562 nagD Shigella dysenteriae Sd197 UMP phosphatase YP_402291.1 572808 R 300267 CDS YP_402292.1 82775945 3798563 complement(573608..574828) 1 NC_007606.1 transcriptional repressor of nag operon; Code: KG; COG: COG1940; N-acetylglucosamine operon transcriptional repressor 574828 nagC 3798563 nagC Shigella dysenteriae Sd197 N-acetylglucosamine operon transcriptional repressor YP_402292.1 573608 R 300267 CDS YP_402293.1 82775946 3798564 complement(574837..575985) 1 NC_007606.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 575985 nagA 3798564 nagA Shigella dysenteriae Sd197 N-acetylglucosamine-6-phosphate deacetylase YP_402293.1 574837 R 300267 CDS YP_402294.1 82775947 3798565 complement(576045..576845) 1 NC_007606.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 576845 nagB 3798565 nagB Shigella dysenteriae Sd197 glucosamine-6-phosphate deaminase YP_402294.1 576045 R 300267 CDS YP_402295.1 82775948 3798566 577179..579125 1 NC_007606.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 579125 nagE 3798566 nagE Shigella dysenteriae Sd197 PTS system N-acetyl glucosamine specific transporter subunit IIABC YP_402295.1 577179 D 300267 CDS YP_402296.1 82775949 3798567 579328..580992 1 NC_007606.1 ''catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; glutaminyl-tRNA synthetase 580992 glnS 3798567 glnS Shigella dysenteriae Sd197 glutaminyl-tRNA synthetase YP_402296.1 579328 D 300267 CDS YP_402297.1 82775950 3798568 complement(581099..581476) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 581476 insB 3798568 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402297.1 581099 R 300267 CDS YP_402298.1 82775951 3798569 complement(581521..581826) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 581826 insA 3798569 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_402298.1 581521 R 300267 CDS YP_402299.1 82775952 3798570 582091..582486 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 582486 3798570 SDY_0617 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402299.1 582091 D 300267 CDS YP_402300.1 82775953 3798571 582716..583078 1 NC_007606.1 hypothetical protein 583078 3798571 SDY_0618 Shigella dysenteriae Sd197 hypothetical protein YP_402300.1 582716 D 300267 CDS YP_402301.1 82775954 3798572 583129..583404 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 583404 insA 3798572 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_402301.1 583129 D 300267 CDS YP_402305.1 82775958 3798576 complement(585361..585807) 1 NC_007606.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 585807 fur 3798576 fur Shigella dysenteriae Sd197 ferric uptake regulator YP_402305.1 585361 R 300267 CDS YP_402306.1 82775959 3798577 complement(586096..586626) 1 NC_007606.1 ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''; flavodoxin FldA 586626 fldA 3798577 fldA Shigella dysenteriae Sd197 flavodoxin FldA YP_402306.1 586096 R 300267 CDS YP_402307.1 82775960 3798578 complement(586766..587128) 1 NC_007606.1 LexA regulated protein 587128 ybfE 3798578 ybfE Shigella dysenteriae Sd197 LexA regulated protein YP_402307.1 586766 R 300267 CDS YP_402308.1 82775961 3799383 complement(587199..587963) 1 NC_007606.1 Code: R; COG: COG0596; hypothetical protein 587963 ybfF 3799383 ybfF Shigella dysenteriae Sd197 hypothetical protein YP_402308.1 587199 R 300267 CDS YP_402309.1 82775962 3799384 588148..588693 1 NC_007606.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 588693 seqA 3799384 seqA Shigella dysenteriae Sd197 replication initiation regulator SeqA YP_402309.1 588148 D 300267 CDS YP_402310.1 82775963 3799385 588719..590359 1 NC_007606.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 590359 pgm 3799385 pgm Shigella dysenteriae Sd197 phosphoglucomutase YP_402310.1 588719 D 300267 CDS YP_402311.1 82775964 3799386 complement(590523..591200) 1 NC_007606.1 transcriptional effector; response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 591200 kdpE 3799386 kdpE Shigella dysenteriae Sd197 DNA-binding transcriptional activator KdpE YP_402311.1 590523 R 300267 CDS YP_402312.1 82775965 3799388 complement(593880..594452) 1 NC_007606.1 ''One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex''; potassium-transporting ATPase subunit C 594452 kdpC 3799388 kdpC Shigella dysenteriae Sd197 potassium-transporting ATPase subunit C YP_402312.1 593880 R 300267 CDS YP_402313.1 82775966 3799391 complement(598183..598272) 1 NC_007606.1 potassium ion accessory transporter KdpF 598272 kdpF 3799391 kdpF Shigella dysenteriae Sd197 potassium ion accessory transporter KdpF YP_402313.1 598183 R 300267 CDS YP_402314.1 82775967 3799392 598585..598791 1 NC_007606.1 hypothetical protein 598791 ybfA 3799392 ybfA Shigella dysenteriae Sd197 hypothetical protein YP_402314.1 598585 D 300267 CDS YP_402315.1 82775968 3799393 599034..602297 1 NC_007606.1 Code: M; COG: COG3209; rhs element protein RhsC 602297 rhsC 3799393 rhsC Shigella dysenteriae Sd197 rhs element protein RhsC YP_402315.1 599034 D 300267 CDS YP_402316.1 82775969 3799394 complement(602307..602702) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 602702 3799394 SDY_0637 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402316.1 602307 R 300267 CDS YP_009000653.1 578793114 18262967 complement(602729..603001) 1 NC_007606.1 insertion element iso-IS1N protein InsA 603001 18262967 SDY_0637a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000653.1 602729 R 300267 CDS YP_402319.1 82775972 3799397 complement(603707..604102) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 604102 3799397 SDY_0640 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402319.1 603707 R 300267 CDS YP_009000654.1 578793115 18262968 complement(604129..604401) 1 NC_007606.1 insertion element iso-IS1N protein InsA 604401 18262968 SDY_0642a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000654.1 604129 R 300267 CDS YP_402321.1 82775974 3799399 604976..605485 1 NC_007606.1 Code: S; COG: COG3272; hypothetical protein 605485 ybgA 3799399 ybgA Shigella dysenteriae Sd197 hypothetical protein YP_402321.1 604976 D 300267 CDS YP_402322.1 82775975 3799400 605482..606900 1 NC_007606.1 photoreactivation; UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 606900 phrB 3799400 phrB Shigella dysenteriae Sd197 deoxyribodipyrimidine photolyase YP_402322.1 605482 D 300267 CDS YP_402323.1 82775976 3799709 608802..609545 1 NC_007606.1 Code: S; COG: COG0327; hydrolase-oxidase 609545 ybgI 3799709 ybgI Shigella dysenteriae Sd197 hydrolase-oxidase YP_402323.1 608802 D 300267 CDS YP_402324.1 82775977 3799710 609568..610224 1 NC_007606.1 Code: E; COG: COG2049; carboxylase 610224 ybgJ 3799710 ybgJ Shigella dysenteriae Sd197 carboxylase YP_402324.1 609568 D 300267 CDS YP_402325.1 82775978 3799711 610218..611150 1 NC_007606.1 Code: E; COG: COG1984; carboxylase 611150 ybgK 3799711 ybgK Shigella dysenteriae Sd197 carboxylase YP_402325.1 610218 D 300267 CDS YP_402326.1 82775979 3799712 611140..611874 1 NC_007606.1 Code: R; COG: COG1540; LamB/YcsF family protein 611874 ybgL 3799712 ybgL Shigella dysenteriae Sd197 LamB/YcsF family protein YP_402326.1 611140 D 300267 CDS YP_402327.1 82775980 3799713 611910..612701 1 NC_007606.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 612701 nei 3799713 nei Shigella dysenteriae Sd197 endonuclease VIII YP_402327.1 611910 D 300267 CDS YP_402328.1 82775981 3799714 complement(612698..613759) 1 NC_007606.1 Code: R; COG: COG3180; transport protein 613759 abrB 3799714 abrB Shigella dysenteriae Sd197 transport protein YP_402328.1 612698 R 300267 CDS YP_402329.1 82775982 3799715 complement(613893..614954) 1 NC_007606.1 hypothetical protein 614954 ybgO 3799715 ybgO Shigella dysenteriae Sd197 hypothetical protein YP_402329.1 613893 R 300267 CDS YP_402330.1 82775983 3799716 complement(614951..615646) 1 NC_007606.1 Code: NU; COG: COG3121; chaperone 615646 ybgP 3799716 ybgP Shigella dysenteriae Sd197 chaperone YP_402330.1 614951 R 300267 CDS YP_009000655.1 578793116 18262969 615569..615841 1 NC_007606.1 insertion element iso-IS1N protein InsA 615841 18262969 SDY_0562a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000655.1 615569 D 300267 CDS YP_402331.1 82775984 3799717 615868..616263 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 616263 3799717 SDY_0653 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402331.1 615868 D 300267 CDS YP_402332.1 82775985 3799719 complement(618980..619546) 1 NC_007606.1 Code: NU; COG: COG3539; fimbrial-like protein 619546 ybgD 3799719 ybgD Shigella dysenteriae Sd197 fimbrial-like protein YP_402332.1 618980 R 300267 CDS YP_402333.1 82775986 3799720 complement(619572..619949) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 619949 insB 3799720 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402333.1 619572 R 300267 CDS YP_402334.1 82775987 3799721 complement(619994..620269) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 620269 insA 3799721 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402334.1 619994 R 300267 CDS YP_402335.1 82775988 3799722 complement(620710..621993) 1 NC_007606.1 ''type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH''; type II citrate synthase 621993 gltA 3799722 gltA Shigella dysenteriae Sd197 type II citrate synthase YP_402335.1 620710 R 300267 CDS YP_402336.1 82775989 3799723 622702..623091 1 NC_007606.1 cytochrome b556; Code: C; COG: COG2009; succinate dehydrogenase cytochrome b556 large membrane subunit 623091 sdhC 3799723 sdhC Shigella dysenteriae Sd197 succinate dehydrogenase cytochrome b556 large membrane subunit YP_402336.1 622702 D 300267 CDS YP_402337.1 82775990 3799724 623085..623432 1 NC_007606.1 Code: C; COG: COG2142; succinate dehydrogenase cytochrome b556 small membrane subunit 623432 sdhD 3799724 sdhD Shigella dysenteriae Sd197 succinate dehydrogenase cytochrome b556 small membrane subunit YP_402337.1 623085 D 300267 CDS YP_402338.1 82775991 3799725 623432..625198 1 NC_007606.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 625198 sdhA 3799725 sdhA Shigella dysenteriae Sd197 succinate dehydrogenase flavoprotein subunit YP_402338.1 623432 D 300267 CDS YP_402339.1 82775992 3799726 625214..625930 1 NC_007606.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 625930 sdhB 3799726 sdhB Shigella dysenteriae Sd197 succinate dehydrogenase iron-sulfur subunit YP_402339.1 625214 D 300267 CDS YP_402340.1 82775993 3799727 625989..626249 1 NC_007606.1 hypothetical protein 626249 3799727 SDY_0663 Shigella dysenteriae Sd197 hypothetical protein YP_402340.1 625989 D 300267 CDS YP_402341.1 82775994 3799728 626231..629032 1 NC_007606.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 629032 sucA 3799728 sucA Shigella dysenteriae Sd197 2-oxoglutarate dehydrogenase E1 YP_402341.1 626231 D 300267 CDS YP_402342.1 82775995 3799209 629047..630264 1 NC_007606.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 630264 sucB 3799209 sucB Shigella dysenteriae Sd197 dihydrolipoamide succinyltransferase YP_402342.1 629047 D 300267 CDS YP_402343.1 82775996 3799210 630358..631524 1 NC_007606.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 631524 sucC 3799210 sucC Shigella dysenteriae Sd197 succinyl-CoA synthetase subunit beta YP_402343.1 630358 D 300267 CDS YP_402344.1 82775997 3799211 631524..632393 1 NC_007606.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 632393 sucD 3799211 sucD Shigella dysenteriae Sd197 succinyl-CoA synthetase subunit alpha YP_402344.1 631524 D 300267 CDS YP_402345.1 82775998 3799212 633099..633374 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 633374 insA 3799212 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402345.1 633099 D 300267 CDS YP_402346.1 82775999 3799213 633419..633796 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 633796 insB 3799213 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402346.1 633419 D 300267 CDS YP_402347.1 82776000 3799214 633874..634149 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 634149 insA 3799214 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402347.1 633874 D 300267 CDS YP_402348.1 82776001 3799215 634194..634571 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 634571 insB 3799215 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402348.1 634194 D 300267 CDS YP_402349.1 82776002 3799216 complement(634675..636045) 1 NC_007606.1 hypothetical protein 636045 3799216 SDY_0672 Shigella dysenteriae Sd197 hypothetical protein YP_402349.1 634675 R 300267 CDS YP_402350.1 82776003 3799217 complement(636049..637290) 1 NC_007606.1 Code: E; COG: COG3799; methylaspartate ammonia-lyase 637290 3799217 SDY_0673 Shigella dysenteriae Sd197 methylaspartate ammonia-lyase YP_402350.1 636049 R 300267 CDS YP_402351.1 82776004 3799218 complement(637290..638654) 1 NC_007606.1 Code: E; COG: COG4865; glutamate mutase subunit E 638654 3799218 SDY_0674 Shigella dysenteriae Sd197 glutamate mutase subunit E YP_402351.1 637290 R 300267 CDS YP_402352.1 82776005 3799219 complement(638673..640061) 1 NC_007606.1 glutamate mutase L 640061 3799219 SDY_0675 Shigella dysenteriae Sd197 glutamate mutase L YP_402352.1 638673 R 300267 CDS YP_402353.1 82776006 3799220 complement(640061..640573) 1 NC_007606.1 converts methylaspartate to L-glutamate; methylaspartate mutase subunit S 640573 3799220 SDY_0676 Shigella dysenteriae Sd197 methylaspartate mutase subunit S YP_402353.1 640061 R 300267 CDS YP_009000656.1 578793117 18262970 641282..641554 1 NC_007606.1 insertion element iso-IS1N protein InsA 641554 18262970 SDY_0676a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000656.1 641282 D 300267 CDS YP_402357.1 82776010 3799224 644083..645654 1 NC_007606.1 Code: C; COG: COG1271; cytochrome d terminal oxidase polypeptide subunit I 645654 cydA 3799224 cydA Shigella dysenteriae Sd197 cytochrome d terminal oxidase polypeptide subunit I YP_402357.1 644083 D 300267 CDS YP_402358.1 82776011 3799225 645670..646809 1 NC_007606.1 Code: C; COG: COG1294; cytochrome d terminal oxidase polypeptide subunit II 646809 cydB 3799225 cydB Shigella dysenteriae Sd197 cytochrome d terminal oxidase polypeptide subunit II YP_402358.1 645670 D 300267 CDS YP_402359.1 82776012 3799226 646824..646937 1 NC_007606.1 Code: S; COG: COG4890; outer membrane lipoprotein 646937 ybgT 3799226 ybgT Shigella dysenteriae Sd197 outer membrane lipoprotein YP_402359.1 646824 D 300267 CDS YP_402360.1 82776013 3799227 646937..647230 1 NC_007606.1 Code: S; COG: COG3790; hypothetical protein 647230 ybgE 3799227 ybgE Shigella dysenteriae Sd197 hypothetical protein YP_402360.1 646937 D 300267 CDS YP_402361.1 82776014 3796634 647380..647784 1 NC_007606.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 647784 ybgC 3796634 ybgC Shigella dysenteriae Sd197 acyl-CoA thioester hydrolase YP_402361.1 647380 D 300267 CDS YP_402362.1 82776015 3796635 647781..648473 1 NC_007606.1 membrane-spanning; maintains integrity of cell envelope; tolerance to group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 648473 tolQ 3796635 tolQ Shigella dysenteriae Sd197 colicin uptake protein TolQ YP_402362.1 647781 D 300267 CDS YP_402363.1 82776016 3796636 648477..648905 1 NC_007606.1 involved in the tonB-independent uptake of group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 648905 tolR 3796636 tolR Shigella dysenteriae Sd197 colicin uptake protein TolR YP_402363.1 648477 D 300267 CDS YP_402364.1 82776017 3796637 648970..650235 1 NC_007606.1 required for outer membrane integrity; ''inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins''; cell envelope integrity inner membrane protein TolA 650235 tolA 3796637 tolA Shigella dysenteriae Sd197 cell envelope integrity inner membrane protein TolA YP_402364.1 648970 D 300267 CDS YP_402365.1 82776018 3796638 650368..651660 1 NC_007606.1 involved in the tonb-independent uptake of group A colicins; forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 651660 tolB 3796638 tolB Shigella dysenteriae Sd197 translocation protein TolB YP_402365.1 650368 D 300267 CDS YP_402366.1 82776019 3796639 651695..652216 1 NC_007606.1 Code: M; COG: COG2885; peptidoglycan-associated outer membrane lipoprotein 652216 pal 3796639 pal Shigella dysenteriae Sd197 peptidoglycan-associated outer membrane lipoprotein YP_402366.1 651695 D 300267 CDS YP_402367.1 82776020 3796640 652226..653017 1 NC_007606.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 653017 ybgF 3796640 ybgF Shigella dysenteriae Sd197 tol-pal system protein YbgF YP_402367.1 652226 D 300267 CDS YP_402368.1 82776021 3796644 653866..654909 1 NC_007606.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 654909 nadA 3796644 nadA Shigella dysenteriae Sd197 quinolinate synthetase YP_402368.1 653866 D 300267 CDS YP_402369.1 82776022 3796645 654947..655666 1 NC_007606.1 Code: H; COG: COG3201; nicotinamide mononucleotide transporter PnuC 655666 pnuC 3796645 pnuC Shigella dysenteriae Sd197 nicotinamide mononucleotide transporter PnuC YP_402369.1 654947 D 300267 CDS YP_402370.1 82776023 3796646 complement(655663..656604) 1 NC_007606.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 656604 ybgR 3796646 ybgR Shigella dysenteriae Sd197 zinc transporter ZitB YP_402370.1 655663 R 300267 CDS YP_402371.1 82776024 3796647 complement(656718..657098) 1 NC_007606.1 homeobox protein 657098 3796647 SDY_0697 Shigella dysenteriae Sd197 homeobox protein YP_402371.1 656718 R 300267 CDS YP_009000657.1 578793118 18262971 657364..657636 1 NC_007606.1 insertion element iso-IS1N protein InsA 657636 18262971 SDY_0699a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000657.1 657364 D 300267 CDS YP_402375.1 82776028 3799479 658187..659239 1 NC_007606.1 DAHP synthetase; phenylalanine repressible; ''catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive''; phospho-2-dehydro-3-deoxyheptonate aldolase 659239 aroG 3799479 aroG Shigella dysenteriae Sd197 phospho-2-dehydro-3-deoxyheptonate aldolase YP_402375.1 658187 D 300267 CDS YP_402376.1 82776029 3799480 complement(659398..660150) 1 NC_007606.1 Code: G; COG: COG0588; phosphoglyceromutase 660150 gpmA 3799480 gpmA Shigella dysenteriae Sd197 phosphoglyceromutase YP_402376.1 659398 R 300267 CDS YP_402377.1 82776030 3799481 complement(660355..661395) 1 NC_007606.1 mutarotase; ''catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose''; aldose 1-epimerase 661395 galM 3799481 galM Shigella dysenteriae Sd197 aldose 1-epimerase YP_402377.1 660355 R 300267 CDS YP_402378.1 82776031 3799482 complement(661389..662537) 1 NC_007606.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 662537 galK 3799482 galK Shigella dysenteriae Sd197 galactokinase YP_402378.1 661389 R 300267 CDS YP_402379.1 82776032 3799483 complement(662541..663587) 1 NC_007606.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 663587 galT 3799483 galT Shigella dysenteriae Sd197 galactose-1-phosphate uridylyltransferase YP_402379.1 662541 R 300267 CDS YP_402380.1 82776033 3799484 complement(663597..664613) 1 NC_007606.1 Code: M; COG: COG1087; UDP-galactose-4-epimerase 664613 galE 3799484 galE Shigella dysenteriae Sd197 UDP-galactose-4-epimerase YP_402380.1 663597 R 300267 CDS YP_402381.1 82776034 3799485 complement(664875..666347) 1 NC_007606.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 666347 modF 3799485 modF Shigella dysenteriae Sd197 molybdenum transport ATP-binding protein ModF YP_402381.1 664875 R 300267 CDS YP_402382.1 82776035 3799486 complement(666415..667203) 1 NC_007606.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 667203 modE 3799486 modE Shigella dysenteriae Sd197 DNA-binding transcriptional regulator ModE YP_402382.1 666415 R 300267 CDS YP_402383.1 82776036 3799487 667332..667481 1 NC_007606.1 hypothetical protein 667481 3799487 SDY_0709 Shigella dysenteriae Sd197 hypothetical protein YP_402383.1 667332 D 300267 CDS YP_402384.1 82776037 3799488 667648..668421 1 NC_007606.1 permease; with ModCB is involved in the high-affinity transport of molybdate; molybdate ABC transporter substrate-binding protein 668421 modA 3799488 modA Shigella dysenteriae Sd197 molybdate ABC transporter substrate-binding protein YP_402384.1 667648 D 300267 CDS YP_402385.1 82776038 3799489 668421..669110 1 NC_007606.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 669110 modB 3799489 modB Shigella dysenteriae Sd197 molybdate ABC transporter permease YP_402385.1 668421 D 300267 CDS YP_402386.1 82776039 3799490 669113..670171 1 NC_007606.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate ABC transporter ATP-binding protein 670171 modC 3799490 modC Shigella dysenteriae Sd197 molybdate ABC transporter ATP-binding protein YP_402386.1 669113 D 300267 CDS YP_402388.1 82776041 3799493 complement(672580..672882) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 672882 3799493 SDY_0715 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402388.1 672580 R 300267 CDS YP_402389.1 82776042 3799494 complement(672953..673348) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 673348 3799494 SDY_0716 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402389.1 672953 R 300267 CDS YP_009000658.1 578793119 18262972 complement(673375..673647) 1 NC_007606.1 insertion element iso-IS1N protein InsA 673647 18262972 SDY_0718a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000658.1 673375 R 300267 CDS YP_402393.1 82776046 3799131 complement(674813..675115) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 675115 3799131 SDY_0720 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402393.1 674813 R 300267 CDS YP_402395.1 82776048 3799133 complement(675741..676100) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 676100 3799133 SDY_0722 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402395.1 675741 R 300267 CDS YP_402396.1 82776049 3799134 676139..676441 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 676441 3799134 SDY_0723 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402396.1 676139 D 300267 CDS YP_402397.1 82776050 3799135 676582..677478 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 677478 3799135 SDY_0724 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402397.1 676582 D 300267 CDS YP_402398.1 82776051 3799136 678909..679673 1 NC_007606.1 bacteriophage protein 679673 3799136 SDY_0725 Shigella dysenteriae Sd197 bacteriophage protein YP_402398.1 678909 D 300267 CDS YP_402399.1 82776052 3799137 679597..680415 1 NC_007606.1 Code: R; COG: COG1783; bacteriophage protein 680415 3799137 SDY_0726 Shigella dysenteriae Sd197 bacteriophage protein YP_402399.1 679597 D 300267 CDS YP_402400.1 82776053 3799138 complement(680338..681171) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 681171 3799138 SDY_0727 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402400.1 680338 R 300267 CDS YP_402401.1 82776054 3799139 complement(681312..681614) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 681614 3799139 SDY_0728 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402401.1 681312 R 300267 CDS YP_402402.2 161950150 3799140 complement(681711..682616) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 682616 3799140 SDY_0729 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402402.2 681711 R 300267 CDS YP_402403.1 82776056 3799141 complement(682574..682939) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 682939 3799141 SDY_0730 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402403.1 682574 R 300267 CDS YP_402404.1 82776057 3799142 683003..683404 1 NC_007606.1 bacteriophage protein 683404 3799142 SDY_0731 Shigella dysenteriae Sd197 bacteriophage protein YP_402404.1 683003 D 300267 CDS YP_402406.1 82776059 3799144 683625..683945 1 NC_007606.1 hypothetical protein 683945 3799144 SDY_0733 Shigella dysenteriae Sd197 hypothetical protein YP_402406.1 683625 D 300267 CDS YP_402407.1 82776060 3799145 683996..684271 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 684271 insA 3799145 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402407.1 683996 D 300267 CDS YP_402408.1 82776061 3799146 684316..684693 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 684693 insB 3799146 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402408.1 684316 D 300267 CDS YP_402409.1 82776062 3799147 complement(684954..686081) 1 NC_007606.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 686081 rumB 3799147 rumB Shigella dysenteriae Sd197 23S rRNA methyluridine methyltransferase YP_402409.1 684954 R 300267 CDS YP_402410.1 82776063 3799148 complement(686122..686610) 1 NC_007606.1 hypothetical protein 686610 ybjO 3799148 ybjO Shigella dysenteriae Sd197 hypothetical protein YP_402410.1 686122 R 300267 CDS YP_402411.1 82776064 3799149 complement(686671..687516) 1 NC_007606.1 permease; Code: E; COG: COG1177; putrescine ABC transporter membrane protein 687516 potI 3799149 potI Shigella dysenteriae Sd197 putrescine ABC transporter membrane protein YP_402411.1 686671 R 300267 CDS YP_402412.1 82776065 3799284 complement(687513..688466) 1 NC_007606.1 permease; Code: E; COG: COG1176; putrescine ABC transporter membrane protein 688466 potH 3799284 potH Shigella dysenteriae Sd197 putrescine ABC transporter membrane protein YP_402412.1 687513 R 300267 CDS YP_402413.1 82776066 3799285 complement(688476..689609) 1 NC_007606.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein 689609 potG 3799285 potG Shigella dysenteriae Sd197 putrescine ABC transporter ATP-binding protein YP_402413.1 688476 R 300267 CDS YP_402414.1 82776067 3799286 complement(689704..690816) 1 NC_007606.1 permease; Code: E; COG: COG0687; putrescine ABC transporter substrate-binding protein 690816 potF 3799286 potF Shigella dysenteriae Sd197 putrescine ABC transporter substrate-binding protein YP_402414.1 689704 R 300267 CDS YP_402415.1 82776068 3799287 complement(691167..691643) 1 NC_007606.1 sensory transduction regulator 691643 ybjN 3799287 ybjN Shigella dysenteriae Sd197 sensory transduction regulator YP_402415.1 691167 R 300267 CDS YP_402416.1 82776069 3799288 complement(691731..692633) 1 NC_007606.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 692633 rimK 3799288 rimK Shigella dysenteriae Sd197 ribosomal protein S6 modification protein YP_402416.1 691731 R 300267 CDS YP_402417.1 82776070 3799289 complement(692694..693416) 1 NC_007606.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 693416 mdaA 3799289 mdaA Shigella dysenteriae Sd197 nitroreductase A YP_402417.1 692694 R 300267 CDS YP_402418.1 82776071 3799290 complement(693400..693687) 1 NC_007606.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 693687 ybjC 3799290 ybjC Shigella dysenteriae Sd197 hypothetical protein YP_402418.1 693400 R 300267 CDS YP_402419.1 82776072 3799291 693847..694104 1 NC_007606.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 694104 grxA 3799291 grxA Shigella dysenteriae Sd197 glutaredoxin YP_402419.1 693847 D 300267 CDS YP_402420.1 82776073 3799292 complement(694134..694511) 1 NC_007606.1 hypothetical protein 694511 ybjM 3799292 ybjM Shigella dysenteriae Sd197 hypothetical protein YP_402420.1 694134 R 300267 CDS YP_402421.1 82776074 3799293 694781..696466 1 NC_007606.1 Code: R; COG: COG2985; hypothetical protein 696466 3799293 SDY_0748 Shigella dysenteriae Sd197 hypothetical protein YP_402421.1 694781 D 300267 CDS YP_402422.1 82776075 3799294 696799..697350 1 NC_007606.1 Code: E; COG: COG1045; hypothetical protein 697350 3799294 SDY_0749 Shigella dysenteriae Sd197 hypothetical protein YP_402422.1 696799 D 300267 CDS YP_402423.1 82776076 3799295 complement(697410..697946) 1 NC_007606.1 Code: S; COG: COG3226; DeoR-type transcriptional regulator 697946 3799295 SDY_0750 Shigella dysenteriae Sd197 DeoR-type transcriptional regulator YP_402423.1 697410 R 300267 CDS YP_402424.1 82776077 3799296 698030..699238 1 NC_007606.1 Code: GEPR; COG: COG0477; DeoR-type transcriptional regulator 699238 3799296 SDY_0751 Shigella dysenteriae Sd197 DeoR-type transcriptional regulator YP_402424.1 698030 D 300267 CDS YP_402425.1 82776078 3799297 699238..699498 1 NC_007606.1 hypothetical protein 699498 3799297 SDY_0752 Shigella dysenteriae Sd197 hypothetical protein YP_402425.1 699238 D 300267 CDS YP_402426.1 82776079 3799298 complement(699492..699869) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 699869 insB 3799298 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402426.1 699492 R 300267 CDS YP_402427.1 82776080 3799299 complement(699914..700189) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 700189 insA 3799299 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_402427.1 699914 R 300267 CDS YP_402428.1 82776081 3799300 complement(700282..701193) 1 NC_007606.1 Code: EP; COG: COG1173; transport system permease 701193 3799300 SDY_0755 Shigella dysenteriae Sd197 transport system permease YP_402428.1 700282 R 300267 CDS YP_402429.1 82776082 3799301 complement(701196..702116) 1 NC_007606.1 Code: EP; COG: COG0601; transport system permease 702116 3799301 SDY_0756 Shigella dysenteriae Sd197 transport system permease YP_402429.1 701196 R 300267 CDS YP_402430.1 82776083 3799302 complement(702134..703672) 1 NC_007606.1 Code: E; COG: COG0747; transport protein 703672 3799302 SDY_0757 Shigella dysenteriae Sd197 transport protein YP_402430.1 702134 R 300267 CDS YP_402431.1 82776084 3799303 complement(703692..705530) 1 NC_007606.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione ABC transporter ATP-binding protein 705530 3799303 SDY_0758 Shigella dysenteriae Sd197 glutathione ABC transporter ATP-binding protein YP_402431.1 703692 R 300267 CDS YP_402432.1 82776085 3799190 complement(705550..706515) 1 NC_007606.1 Code: E; COG: COG1446; L-asparaginase 706515 ybiK 3799190 ybiK Shigella dysenteriae Sd197 L-asparaginase YP_402432.1 705550 R 300267 CDS YP_402433.1 82776086 3799191 706719..707954 1 NC_007606.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 707954 moeA 3799191 moeA Shigella dysenteriae Sd197 molybdopterin biosynthesis protein MoeA YP_402433.1 706719 D 300267 CDS YP_402434.1 82776087 3799192 707954..708703 1 NC_007606.1 ''ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase''; molybdopterin biosynthesis protein MoeB 708703 moeB 3799192 moeB Shigella dysenteriae Sd197 molybdopterin biosynthesis protein MoeB YP_402434.1 707954 D 300267 CDS YP_402435.2 161950149 3799193 complement(708779..709441) 1 NC_007606.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 709441 mipB 3799193 mipB Shigella dysenteriae Sd197 fructose-6-phosphate aldolase YP_402435.2 708779 R 300267 CDS YP_402436.1 82776089 3799194 709545..710471 1 NC_007606.1 Code: O; COG: COG1180; pyruvate formate-lyase 2 activating enzyme 710471 ybiY 3799194 ybiY Shigella dysenteriae Sd197 pyruvate formate-lyase 2 activating enzyme YP_402436.1 709545 D 300267 CDS YP_402437.1 82776090 3799195 710477..712909 1 NC_007606.1 Code: C; COG: COG1882; formate acetyltransferase 712909 ybiW 3799195 ybiW Shigella dysenteriae Sd197 formate acetyltransferase YP_402437.1 710477 D 300267 CDS YP_402438.1 82776091 3799196 713055..713711 1 NC_007606.1 Code: R; COG: COG0561; hypothetical protein 713711 3799196 SDY_0765 Shigella dysenteriae Sd197 hypothetical protein YP_402438.1 713055 D 300267 CDS YP_402439.1 82776092 3799197 complement(713708..714103) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 714103 3799197 SDY_0766 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402439.1 713708 R 300267 CDS YP_009000659.1 578793120 18262973 complement(714130..714402) 1 NC_007606.1 insertion element iso-IS1N protein InsA 714402 18262973 SDY_0767a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000659.1 714130 R 300267 CDS YP_402440.1 82776093 3799198 complement(714683..715228) 1 NC_007606.1 Code: K; COG: COG1396; regulatory protein 715228 3799198 SDY_0767 Shigella dysenteriae Sd197 regulatory protein YP_402440.1 714683 R 300267 CDS YP_402442.1 82776095 3799200 complement(716050..716763) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 716763 3799200 SDY_0769 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402442.1 716050 R 300267 CDS YP_402443.1 82776096 3799201 complement(716904..717206) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 717206 3799201 SDY_0770 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402443.1 716904 R 300267 CDS YP_402444.1 82776097 3799202 717245..717574 1 NC_007606.1 hypothetical protein 717574 3799202 SDY_0771 Shigella dysenteriae Sd197 hypothetical protein YP_402444.1 717245 D 300267 CDS YP_402445.1 82776098 3799203 717561..718613 1 NC_007606.1 phage tail fiber protein 718613 3799203 SDY_0772 Shigella dysenteriae Sd197 phage tail fiber protein YP_402445.1 717561 D 300267 CDS YP_402446.1 82776099 3799204 718914..719540 1 NC_007606.1 hypothetical protein 719540 3799204 SDY_0773 Shigella dysenteriae Sd197 hypothetical protein YP_402446.1 718914 D 300267 CDS YP_402447.1 82776100 3799205 719801..720517 1 NC_007606.1 DNA modification protein 720517 3799205 SDY_0774 Shigella dysenteriae Sd197 DNA modification protein YP_402447.1 719801 D 300267 CDS YP_402448.1 82776101 3799206 720885..722144 1 NC_007606.1 hypothetical protein 722144 ybiU 3799206 ybiU Shigella dysenteriae Sd197 hypothetical protein YP_402448.1 720885 D 300267 CDS YP_402449.1 82776102 3799207 complement(722385..723977) 1 NC_007606.1 Code: R; COG: COG0488; ATPase 723977 ybiT 3799207 ybiT Shigella dysenteriae Sd197 ATPase YP_402449.1 722385 R 300267 CDS YP_402450.1 82776103 3799208 724196..725116 1 NC_007606.1 Code: S; COG: COG1376; hypothetical protein 725116 ybiS 3799208 ybiS Shigella dysenteriae Sd197 hypothetical protein YP_402450.1 724196 D 300267 CDS YP_402452.1 82776105 3797880 complement(726290..726757) 1 NC_007606.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 726757 3797880 SDY_0779 Shigella dysenteriae Sd197 manganese transport regulator MntR YP_402452.1 726290 R 300267 CDS YP_402453.1 82776106 3797881 727343..728926 1 NC_007606.1 Code: R; COG: COG2194; sulfatase 728926 ybiP 3797881 ybiP Shigella dysenteriae Sd197 sulfatase YP_402453.1 727343 D 300267 CDS YP_402454.1 82776107 3797882 complement(728975..729490) 1 NC_007606.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 729490 ompX 3797882 ompX Shigella dysenteriae Sd197 outer membrane protein X YP_402454.1 728975 R 300267 CDS YP_402455.1 82776108 3797884 731030..731533 1 NC_007606.1 for starvation conditions; binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 731533 dps 3797884 dps Shigella dysenteriae Sd197 DNA starvation/stationary phase protection protein Dps YP_402455.1 731030 D 300267 CDS YP_402456.1 82776109 3797885 complement(731934..732209) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 732209 insA 3797885 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_402456.1 731934 R 300267 CDS YP_402457.1 82776110 3797886 732583..733329 1 NC_007606.1 permease; similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter substrate-binding protein 733329 glnH 3797886 glnH Shigella dysenteriae Sd197 glutamine ABC transporter substrate-binding protein YP_402457.1 732583 D 300267 CDS YP_402458.1 82776111 3797887 733468..734127 1 NC_007606.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 734127 glnP 3797887 glnP Shigella dysenteriae Sd197 glutamine ABC transporter permease YP_402458.1 733468 D 300267 CDS YP_402459.1 82776112 3797888 734124..734846 1 NC_007606.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 734846 glnQ 3797888 glnQ Shigella dysenteriae Sd197 glutamine ABC transporter ATP-binding protein YP_402459.1 734124 D 300267 CDS YP_402460.1 82776113 3797890 complement(736332..736727) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 736727 3797890 SDY_0789 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402460.1 736332 R 300267 CDS YP_009000660.1 578793121 18262974 complement(736754..737026) 1 NC_007606.1 insertion element iso-IS1N protein InsA 737026 18262974 SDY_0788a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000660.1 736754 R 300267 CDS YP_402461.1 82776114 3797891 complement(737959..738966) 1 NC_007606.1 Code: R; COG: COG3129; SAM-dependent methyltransferase 738966 ybiN 3797891 ybiN Shigella dysenteriae Sd197 SAM-dependent methyltransferase YP_402461.1 737959 R 300267 CDS YP_402462.2 578793122 3797892 739161..739421 1 NC_007606.1 hypothetical protein 739421 ybiM 3797892 ybiM Shigella dysenteriae Sd197 hypothetical protein YP_402462.2 739161 D 300267 CDS YP_402463.1 82776116 3797893 739686..740018 1 NC_007606.1 hypothetical protein 740018 3797893 SDY_0792 Shigella dysenteriae Sd197 hypothetical protein YP_402463.1 739686 D 300267 CDS YP_402464.1 82776117 3797894 740057..741403 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 741403 3797894 SDY_0793 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_402464.1 740057 D 300267 CDS YP_402465.1 82776118 3797895 741577..743406 1 NC_007606.1 ''Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein''; catecholate siderophore receptor Fiu 743406 3797895 SDY_0794 Shigella dysenteriae Sd197 catecholate siderophore receptor Fiu YP_402465.1 741577 D 300267 CDS YP_402466.2 161950148 3797896 743448..744125 1 NC_007606.1 Code: S; COG: COG3128; hydroxylase 744125 ybiX 3797896 ybiX Shigella dysenteriae Sd197 hydroxylase YP_402466.2 743448 D 300267 CDS YP_402467.1 82776120 3797897 744199..744465 1 NC_007606.1 Code: T; COG: COG1734; hypothetical protein 744465 ybiI 3797897 ybiI Shigella dysenteriae Sd197 hypothetical protein YP_402467.1 744199 D 300267 CDS YP_402468.1 82776121 3797898 744731..744991 1 NC_007606.1 hypothetical protein 744991 ybiJ 3797898 ybiJ Shigella dysenteriae Sd197 hypothetical protein YP_402468.1 744731 D 300267 CDS YP_402469.1 82776122 3799074 complement(745219..746304) 1 NC_007606.1 Code: C; COG: COG2055; hypothetical protein 746304 ybiC 3799074 ybiC Shigella dysenteriae Sd197 hypothetical protein YP_402469.1 745219 R 300267 CDS YP_402470.1 82776123 3799075 complement(746445..747407) 1 NC_007606.1 Code: E; COG: COG0547; glycosyl transferase 747407 ybiB 3799075 ybiB Shigella dysenteriae Sd197 glycosyl transferase YP_402470.1 746445 R 300267 CDS YP_402471.1 82776124 3799076 complement(747435..749585) 1 NC_007606.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 749585 dinG 3799076 dinG Shigella dysenteriae Sd197 ATP-dependent DNA helicase DinG YP_402471.1 747435 R 300267 CDS YP_402472.1 82776125 3799077 complement(749982..750377) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 750377 3799077 SDY_0801 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402472.1 749982 R 300267 CDS YP_009000661.1 578793123 18262975 complement(750404..750676) 1 NC_007606.1 insertion element iso-IS1N protein InsA 750676 18262975 SDY_0801a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000661.1 750404 R 300267 CDS YP_402474.1 82776127 3799079 750928..751266 1 NC_007606.1 hypothetical protein 751266 3799079 SDY_0803 Shigella dysenteriae Sd197 hypothetical protein YP_402474.1 750928 D 300267 CDS YP_009000662.1 578793124 18262976 751302..751574 1 NC_007606.1 insertion element iso-IS1N protein InsA 751574 18262976 SDY_803a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000662.1 751302 D 300267 CDS YP_402476.1 82776129 3799081 751601..751996 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 751996 3799081 SDY_0805 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402476.1 751601 D 300267 CDS YP_402477.1 82776130 3799082 complement(752216..753580) 1 NC_007606.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 753580 rhlE 3799082 rhlE Shigella dysenteriae Sd197 ATP-dependent RNA helicase RhlE YP_402477.1 752216 R 300267 CDS YP_402478.1 82776131 3799083 753797..754480 1 NC_007606.1 Code: K; COG: COG1309; DNA-binding transcriptional regulator 754480 ybiH 3799083 ybiH Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YP_402478.1 753797 D 300267 CDS YP_402479.1 82776132 3799084 754480..755478 1 NC_007606.1 Code: M; COG: COG0845; hypothetical protein 755478 3799084 SDY_0808 Shigella dysenteriae Sd197 hypothetical protein YP_402479.1 754480 D 300267 CDS YP_402480.1 82776133 3799085 755456..757207 1 NC_007606.1 Code: V; COG: COG1131; ATPase 757207 ybhF 3799085 ybhF Shigella dysenteriae Sd197 ATPase YP_402480.1 755456 D 300267 CDS YP_402481.1 82776134 3799086 757200..758333 1 NC_007606.1 Code: V; COG: COG0842; hypothetical protein 758333 ybhS 3799086 ybhS Shigella dysenteriae Sd197 hypothetical protein YP_402481.1 757200 D 300267 CDS YP_402482.1 82776135 3799087 758344..759450 1 NC_007606.1 Code: V; COG: COG0842; hypothetical protein 759450 ybhR 3799087 ybhR Shigella dysenteriae Sd197 hypothetical protein YP_402482.1 758344 D 300267 CDS YP_402483.1 82776136 3799088 complement(759412..759822) 1 NC_007606.1 hypothetical protein 759822 ybhQ 3799088 ybhQ Shigella dysenteriae Sd197 hypothetical protein YP_402483.1 759412 R 300267 CDS YP_402484.1 82776137 3799089 759955..760716 1 NC_007606.1 Code: R; COG: COG3568; hypothetical protein 760716 ybhP 3799089 ybhP Shigella dysenteriae Sd197 hypothetical protein YP_402484.1 759955 D 300267 CDS YP_402485.1 82776138 3799090 760713..761945 1 NC_007606.1 Code: I; COG: COG1502; cardiolipin synthase 2 761945 ybhO 3799090 ybhO Shigella dysenteriae Sd197 cardiolipin synthase 2 YP_402485.1 760713 D 300267 CDS YP_402486.1 82776139 3799091 761945..762685 1 NC_007606.1 Code: S; COG: COG0392; hypothetical protein 762685 ybhN 3799091 ybhN Shigella dysenteriae Sd197 hypothetical protein YP_402486.1 761945 D 300267 CDS YP_402487.1 82776140 3799092 complement(762669..762995) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1N protein InsA 762995 3799092 SDY_0816 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_402487.1 762669 R 300267 CDS YP_402488.1 82776141 3795808 complement(763048..763602) 1 NC_007606.1 Code: R; COG: COG0670; hypothetical protein 763602 ybhL 3795808 ybhL Shigella dysenteriae Sd197 hypothetical protein YP_402488.1 763048 R 300267 CDS YP_402489.2 161950147 3795809 complement(763714..764109) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 764109 3795809 SDY_0818 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402489.2 763714 R 300267 CDS YP_009000663.1 578793125 18262977 complement(764136..764408) 1 NC_007606.1 insertion element iso-IS1N protein InsA 764408 18262977 SDY_0819a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000663.1 764136 R 300267 CDS YP_402490.1 82776143 3795810 764468..764833 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 764833 3795810 SDY_0819 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402490.1 764468 D 300267 CDS YP_402491.2 161950146 3795811 764791..765696 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 765696 3795811 SDY_0820 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402491.2 764791 D 300267 CDS YP_402492.1 82776145 3795812 complement(766002..766454) 1 NC_007606.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase large subunit 766454 moaE 3795812 moaE Shigella dysenteriae Sd197 molybdopterin synthase large subunit YP_402492.1 766002 R 300267 CDS YP_402493.1 82776146 3795813 complement(766456..766701) 1 NC_007606.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 766701 moaD 3795813 moaD Shigella dysenteriae Sd197 molybdopterin synthase small subunit YP_402493.1 766456 R 300267 CDS YP_402494.1 82776147 3795814 complement(766694..767179) 1 NC_007606.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein C 767179 moaC 3795814 moaC Shigella dysenteriae Sd197 molybdenum cofactor biosynthesis protein C YP_402494.1 766694 R 300267 CDS YP_402495.1 82776148 3795815 complement(767182..767694) 1 NC_007606.1 Code: H; COG: COG0521; molybdopterin biosynthesis, protein B 767694 moaB 3795815 moaB Shigella dysenteriae Sd197 molybdopterin biosynthesis, protein B YP_402495.1 767182 R 300267 CDS YP_402496.1 82776149 3795816 complement(767716..768705) 1 NC_007606.1 ''together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z''; molybdenum cofactor biosynthesis protein A 768705 moaA 3795816 moaA Shigella dysenteriae Sd197 molybdenum cofactor biosynthesis protein A YP_402496.1 767716 R 300267 CDS YP_402497.1 82776150 3795817 769102..770010 1 NC_007606.1 Code: S; COG: COG0391; structural protein 770010 ybhK 3795817 ybhK Shigella dysenteriae Sd197 structural protein YP_402497.1 769102 D 300267 CDS YP_402498.1 82776151 3795818 complement(770201..772222) 1 NC_007606.1 DNA repair; ''The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion''; excinuclease ABC subunit B 772222 uvrB 3795818 uvrB Shigella dysenteriae Sd197 excinuclease ABC subunit B YP_402498.1 770201 R 300267 CDS YP_402499.1 82776152 3795819 complement(772801..773478) 1 NC_007606.1 ''DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium''; dithiobiotin synthetase 773478 bioD 3795819 bioD Shigella dysenteriae Sd197 dithiobiotin synthetase YP_402499.1 772801 R 300267 CDS YP_402500.1 82776153 3795820 complement(773471..774226) 1 NC_007606.1 reaction prior to pimeloyl CoA; ''methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth''; biotin biosynthesis protein BioC 774226 bioC 3795820 bioC Shigella dysenteriae Sd197 biotin biosynthesis protein BioC YP_402500.1 773471 R 300267 CDS YP_402501.1 82776154 3795821 complement(774213..775367) 1 NC_007606.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 775367 bioF 3795821 bioF Shigella dysenteriae Sd197 8-amino-7-oxononanoate synthase YP_402501.1 774213 R 300267 CDS YP_402502.1 82776155 3795822 complement(775364..776404) 1 NC_007606.1 possible sulfur insertion; Code: H; COG: COG0502; biotin synthase 776404 bioB 3795822 bioB Shigella dysenteriae Sd197 biotin synthase YP_402502.1 775364 R 300267 CDS YP_402503.1 82776156 3795823 776492..777781 1 NC_007606.1 ''catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate''; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 777781 bioA 3795823 bioA Shigella dysenteriae Sd197 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_402503.1 776492 D 300267 CDS YP_402504.1 82776157 3795824 777840..778316 1 NC_007606.1 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 778316 ybhB 3795824 ybhB Shigella dysenteriae Sd197 kinase inhibitor protein YP_402504.1 777840 D 300267 CDS YP_402505.1 82776158 3795825 778896..780659 1 NC_007606.1 Code: S; COG: COG4886; invasion plasmid antigen 780659 ipaH_1 3795825 ipaH_1 Shigella dysenteriae Sd197 invasion plasmid antigen YP_402505.1 778896 D 300267 CDS YP_402506.1 82776159 3795826 780984..781286 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 781286 3795826 SDY_0835 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402506.1 780984 D 300267 CDS YP_402507.1 82776160 3795827 781427..782140 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 782140 3795827 SDY_0836 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402507.1 781427 D 300267 CDS YP_402509.1 82776162 3799460 complement(782376..783008) 1 NC_007606.1 Code: O; COG: COG0625; transferase 783008 yliJ 3799460 yliJ Shigella dysenteriae Sd197 transferase YP_402509.1 782376 R 300267 CDS YP_402510.1 82776163 3799461 complement(783238..783633) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 783633 3799461 SDY_0839 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402510.1 783238 R 300267 CDS YP_009000664.1 578793126 18262978 complement(783660..783932) 1 NC_007606.1 insertion element iso-IS1N protein InsA 783932 18262978 SDY_0839a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000664.1 783660 R 300267 CDS YP_402512.1 82776165 3799463 784024..785226 1 NC_007606.1 penicillin-binding protein 6; ''penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''; D-alanyl-D-alanine carboxypeptidase 785226 dacC 3799463 dacC Shigella dysenteriae Sd197 D-alanyl-D-alanine carboxypeptidase YP_402512.1 784024 D 300267 CDS YP_402513.1 82776166 3799464 complement(785273..786031) 1 NC_007606.1 Code: KG; COG: COG1349; DNA-binding transcriptional repressor DeoR 786031 deoR 3799464 deoR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor DeoR YP_402513.1 785273 R 300267 CDS YP_402514.1 82776167 3799465 complement(786089..786685) 1 NC_007606.1 Code: I; COG: COG0671; undecaprenyl pyrophosphate phosphatase 786685 ybjG 3799465 ybjG Shigella dysenteriae Sd197 undecaprenyl pyrophosphate phosphatase YP_402514.1 786089 R 300267 CDS YP_402515.1 82776168 3799467 788515..788817 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 788817 3799467 SDY_0845 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402515.1 788515 D 300267 CDS YP_402516.1 82776169 3799468 788862..789683 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 789683 3799468 SDY_0846 Shigella dysenteriae Sd197 insertion sequence element IS911 integrase core domain-containing protein YP_402516.1 788862 D 300267 CDS YP_402517.1 82776170 3799469 790070..790783 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 790783 3799469 SDY_0847 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402517.1 790070 D 300267 CDS YP_402518.1 82776171 3799470 790780..791334 1 NC_007606.1 hypothetical protein 791334 3799470 SDY_0848 Shigella dysenteriae Sd197 hypothetical protein YP_402518.1 790780 D 300267 CDS YP_402519.1 82779656 3799471 792549..792851 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 792851 3799471 SDY_0849 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402519.1 792549 D 300267 CDS YP_402520.1 82779655 3799472 792992..793795 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 793795 3799472 SDY_0850 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402520.1 792992 D 300267 CDS YP_402521.1 82776172 3799474 795138..799652 1 NC_007606.1 Code: R; COG: COG2373; large extracellular alpha-helical protein 799652 yfaSR 3799474 yfaSR Shigella dysenteriae Sd197 large extracellular alpha-helical protein YP_402521.1 795138 D 300267 CDS YP_402522.1 82776173 3799475 799653..801302 1 NC_007606.1 Code: S; COG: COG5445; hypothetical protein 801302 3799475 SDY_0853 Shigella dysenteriae Sd197 hypothetical protein YP_402522.1 799653 D 300267 CDS YP_402525.2 161950145 3799652 802357..805206 1 NC_007606.1 probable histidine kinase acting on RcsB; Code: T; COG: COG0642; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 805206 rcsC 3799652 rcsC Shigella dysenteriae Sd197 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_402525.2 802357 D 300267 CDS YP_402526.1 82776177 3799653 complement(805406..806056) 1 NC_007606.1 sensor, RcsC; two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 806056 rcsB 3799653 rcsB Shigella dysenteriae Sd197 transcriptional regulator RcsB YP_402526.1 805406 R 300267 CDS YP_402527.1 82776178 3799654 complement(806073..808745) 1 NC_007606.1 Code: T; COG: COG0642; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 808745 yojN 3799654 yojN Shigella dysenteriae Sd197 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_402527.1 806073 R 300267 CDS YP_402528.1 82776179 3799655 complement(809182..809577) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 809577 3799655 SDY_0859 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402528.1 809182 R 300267 CDS YP_009000665.1 578793127 18262979 complement(809604..809876) 1 NC_007606.1 insertion element iso-IS1N protein InsA 809876 18262979 SDY_0861a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000665.1 809604 R 300267 CDS YP_402530.1 82776181 3799657 810258..811385 1 NC_007606.1 Ib;c; allows for ions and hydrophilic solutes to cross the outer membrane; porin 811385 ompC 3799657 ompC Shigella dysenteriae Sd197 porin YP_402530.1 810258 D 300267 CDS YP_402531.1 82776182 3799658 811497..812552 1 NC_007606.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 812552 yojL 3799658 yojL Shigella dysenteriae Sd197 thiamine biosynthesis lipoprotein ApbE YP_402531.1 811497 D 300267 CDS YP_402532.1 82776183 3799659 812626..813690 1 NC_007606.1 transcription activator/repressor; Code: F; COG: COG2169; O6-methylguanine-DNA methyltransferase 813690 ada 3799659 ada Shigella dysenteriae Sd197 O6-methylguanine-DNA methyltransferase YP_402532.1 812626 D 300267 CDS YP_402533.1 82776184 3799660 813690..814340 1 NC_007606.1 Code: L; COG: COG3145; DNA repair system specific for alkylated DNA 814340 alkB 3799660 alkB Shigella dysenteriae Sd197 DNA repair system specific for alkylated DNA YP_402533.1 813690 D 300267 CDS YP_402534.1 82776185 3799661 814416..816059 1 NC_007606.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding protein 816059 yojI 3799661 yojI Shigella dysenteriae Sd197 multidrug transporter membrane protein/ATP-binding protein YP_402534.1 814416 D 300267 CDS YP_402535.1 82776186 3799662 816277..817923 1 NC_007606.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 817923 yojH 3799662 yojH Shigella dysenteriae Sd197 malate:quinone oxidoreductase YP_402535.1 816277 D 300267 CDS YP_402536.1 82776187 3799663 complement(818619..819395) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 819395 3799663 SDY_0867 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402536.1 818619 R 300267 CDS YP_402537.1 82776188 3799664 complement(819536..819838) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 819838 3799664 SDY_0868 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402537.1 819536 R 300267 CDS YP_402538.1 82776189 3799666 820463..820957 1 NC_007606.1 electron transfer; Predicted role in electron transfer to the periplasmic nitrate reductase NapA; ferredoxin-type protein 820957 napF 3799666 napF Shigella dysenteriae Sd197 ferredoxin-type protein YP_402538.1 820463 D 300267 CDS YP_402539.1 82776190 3799667 820947..821210 1 NC_007606.1 Code: P; COG: COG3062; assembly protein for periplasmic nitrate reductase 821210 napD 3799667 napD Shigella dysenteriae Sd197 assembly protein for periplasmic nitrate reductase YP_402539.1 820947 D 300267 CDS YP_402540.1 82776191 3799668 821207..823693 1 NC_007606.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 823693 napA 3799668 napA Shigella dysenteriae Sd197 nitrate reductase catalytic subunit YP_402540.1 821207 D 300267 CDS YP_402541.1 82776192 3799669 823700..824395 1 NC_007606.1 electron transfer; part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic subunit 824395 napG 3799669 napG Shigella dysenteriae Sd197 quinol dehydrogenase periplasmic subunit YP_402541.1 823700 D 300267 CDS YP_402542.1 82776193 3799670 824382..825245 1 NC_007606.1 electron transfer; part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane subunit 825245 napH 3799670 napH Shigella dysenteriae Sd197 quinol dehydrogenase membrane subunit YP_402542.1 824382 D 300267 CDS YP_402543.2 161950144 3799671 825242..825691 1 NC_007606.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 825691 napB 3799671 napB Shigella dysenteriae Sd197 citrate reductase cytochrome c-type subunit YP_402543.2 825242 D 300267 CDS YP_402544.1 82776195 3796881 825701..826303 1 NC_007606.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 826303 napC 3796881 napC Shigella dysenteriae Sd197 cytochrome c-type protein NapC YP_402544.1 825701 D 300267 CDS YP_402545.1 82776196 3796882 826322..826939 1 NC_007606.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 826939 ccmA 3796882 ccmA Shigella dysenteriae Sd197 cytochrome c biogenesis protein CcmA YP_402545.1 826322 D 300267 CDS YP_402546.1 82776197 3796883 826936..827598 1 NC_007606.1 cytochrome c-type biogenesis protein; Code: O; COG: COG2386; heme exporter protein B 827598 ccmB 3796883 ccmB Shigella dysenteriae Sd197 heme exporter protein B YP_402546.1 826936 D 300267 CDS YP_402547.1 82776198 3796884 827640..828377 1 NC_007606.1 Code: O; COG: COG0755; heme exporter protein C 828377 ccmC 3796884 ccmC Shigella dysenteriae Sd197 heme exporter protein C YP_402547.1 827640 D 300267 CDS YP_402548.1 82776199 3796885 828374..828583 1 NC_007606.1 Code: U; COG: COG3114; heme exporter protein C 828583 ccmD 3796885 ccmD Shigella dysenteriae Sd197 heme exporter protein C YP_402548.1 828374 D 300267 CDS YP_402549.1 82776200 3796886 828580..829059 1 NC_007606.1 possible subunit of a heme lyase; CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 829059 ccmE 3796886 ccmE Shigella dysenteriae Sd197 cytochrome c-type biogenesis protein CcmE YP_402549.1 828580 D 300267 CDS YP_402550.1 82776201 3796887 829056..830999 1 NC_007606.1 Code: O; COG: COG1138; cytochrome c-type biogenesis protein 830999 ccmF 3796887 ccmF Shigella dysenteriae Sd197 cytochrome c-type biogenesis protein YP_402550.1 829056 D 300267 CDS YP_402551.1 82776202 3796888 830996..831553 1 NC_007606.1 possibly involved in biogenesis of cytochrome c; Code: OC; COG: COG0526; disulfide oxidoreductase 831553 dsbE 3796888 dsbE Shigella dysenteriae Sd197 disulfide oxidoreductase YP_402551.1 830996 D 300267 CDS YP_402552.1 82776203 3796889 831550..832602 1 NC_007606.1 Code: O; COG: COG4235; subunit of heme lyase 832602 ccmH 3796889 ccmH Shigella dysenteriae Sd197 subunit of heme lyase YP_402552.1 831550 D 300267 CDS YP_402553.1 82776204 3796890 complement(832813..833460) 1 NC_007606.1 sensor NarQ; nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 833460 narP 3796890 narP Shigella dysenteriae Sd197 transcriptional regulator NarP YP_402553.1 832813 R 300267 CDS YP_402554.1 82776205 3796891 complement(834089..834484) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 834484 3796891 SDY_0886 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402554.1 834089 R 300267 CDS YP_009000666.1 578793128 18262980 complement(834511..834783) 1 NC_007606.1 insertion element iso-IS1N protein InsA 834783 18262980 SDY_0886a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000666.1 834511 R 300267 CDS YP_402556.1 82776207 3796893 complement(835389..835664) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 835664 insA 3796893 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402556.1 835389 R 300267 CDS YP_402557.1 82776208 3796894 835867..837921 1 NC_007606.1 Code: MU; COG: COG3468; ATPase 837921 yejO 3796894 yejO Shigella dysenteriae Sd197 ATPase YP_402557.1 835867 D 300267 CDS YP_402558.1 82776209 3796896 complement(838174..839934) 1 NC_007606.1 Code: R; COG: COG3083; sulfatase 839934 yejM 3796896 yejM Shigella dysenteriae Sd197 sulfatase YP_402558.1 838174 R 300267 CDS YP_402559.1 82776210 3796897 complement(839954..840181) 1 NC_007606.1 Code: S; COG: COG3082; hypothetical protein 840181 yejL 3796897 yejL Shigella dysenteriae Sd197 hypothetical protein YP_402559.1 839954 R 300267 CDS YP_402560.1 82776211 3796898 840363..841370 1 NC_007606.1 Code: R; COG: COG3081; nucleoid-associated protein NdpA 841370 yejK 3796898 yejK Shigella dysenteriae Sd197 nucleoid-associated protein NdpA YP_402560.1 840363 D 300267 CDS YP_402561.1 82776212 3799304 complement(841509..841793) 1 NC_007606.1 ''the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response''; 50S ribosomal protein L25 841793 rplY 3799304 rplY Shigella dysenteriae Sd197 50S ribosomal protein L25 YP_402561.1 841509 R 300267 CDS YP_402562.1 82776213 3799305 complement(841918..843678) 1 NC_007606.1 Code: KL; COG: COG1061; ATP-dependent helicase 843678 yejH 3799305 yejH Shigella dysenteriae Sd197 ATP-dependent helicase YP_402562.1 841918 R 300267 CDS YP_402563.1 82776214 3799306 843828..844523 1 NC_007606.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 844523 rsuA 3799306 rsuA Shigella dysenteriae Sd197 16S rRNA pseudouridylate synthase A YP_402563.1 843828 D 300267 CDS YP_402564.1 82776215 3799307 844551..845741 1 NC_007606.1 transmembrane protein; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 845741 bcr 3799307 bcr Shigella dysenteriae Sd197 bicyclomycin/multidrug efflux system protein YP_402564.1 844551 D 300267 CDS YP_402565.1 82776216 3799308 846074..846418 1 NC_007606.1 hypothetical protein 846418 yejG 3799308 yejG Shigella dysenteriae Sd197 hypothetical protein YP_402565.1 846074 D 300267 CDS YP_402566.1 82776217 3799309 complement(846422..848011) 1 NC_007606.1 Code: R; COG: COG4172; ATPase 848011 yejF 3799309 yejF Shigella dysenteriae Sd197 ATPase YP_402566.1 846422 R 300267 CDS YP_402567.1 82776218 3799310 complement(848013..849038) 1 NC_007606.1 Code: R; COG: COG4239; transport system permease 849038 yejE 3799310 yejE Shigella dysenteriae Sd197 transport system permease YP_402567.1 848013 R 300267 CDS YP_402568.1 82776219 3799311 complement(849038..850132) 1 NC_007606.1 Code: R; COG: COG4174; transport system permease 850132 yejB 3799311 yejB Shigella dysenteriae Sd197 transport system permease YP_402568.1 849038 R 300267 CDS YP_402569.2 161950143 3799312 complement(850133..851947) 1 NC_007606.1 Code: E; COG: COG4166; hypothetical protein 851947 yejA 3799312 yejA Shigella dysenteriae Sd197 hypothetical protein YP_402569.2 850133 R 300267 CDS YP_402570.1 82776221 3799313 complement(852029..853585) 1 NC_007606.1 Code: T; COG: COG2200; hypothetical protein 853585 rtn 3799313 rtn Shigella dysenteriae Sd197 hypothetical protein YP_402570.1 852029 R 300267 CDS YP_402571.1 82776222 3799314 complement(853766..854332) 1 NC_007606.1 ''by similarity, Spr seems to have peptidase activity; involved in thermoresistance''; outer membrane lipoprotein 854332 spr 3799314 spr Shigella dysenteriae Sd197 outer membrane lipoprotein YP_402571.1 853766 R 300267 CDS YP_402572.1 82776223 3799315 complement(854744..855493) 1 NC_007606.1 Code: I; COG: COG0671; hypothetical protein 855493 3799315 SDY_0905 Shigella dysenteriae Sd197 hypothetical protein YP_402572.1 854744 R 300267 CDS YP_402573.1 82776224 3799316 complement(855496..856482) 1 NC_007606.1 Code: R; COG: COG0523; hypothetical protein 856482 yeiR 3799316 yeiR Shigella dysenteriae Sd197 hypothetical protein YP_402573.1 855496 R 300267 CDS YP_402575.2 161950142 3799318 complement(858289..858861) 1 NC_007606.1 ''Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein''; elongation factor P 858861 yeiP 3799318 yeiP Shigella dysenteriae Sd197 elongation factor P YP_402575.2 858289 R 300267 CDS YP_009000667.1 578793129 18262981 859016..859270 1 NC_007606.1 hypothetical protein 859270 18262981 SDY_0907a Shigella dysenteriae Sd197 hypothetical protein YP_009000667.1 859016 D 300267 CDS YP_402576.1 82776227 3799319 complement(859267..860448) 1 NC_007606.1 Code: GEPR; COG: COG0477; transporter 860448 yeiO 3799319 yeiO Shigella dysenteriae Sd197 transporter YP_402576.1 859267 R 300267 CDS YP_402577.1 82776228 3799320 complement(860588..860803) 1 NC_007606.1 insertion element iso-IS1n protein InsB 860803 3799320 SDY_0910 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402577.1 860588 R 300267 CDS YP_009000668.1 578793130 18262982 complement(861009..861281) 1 NC_007606.1 insertion element iso-IS1N protein InsA 861281 18262982 SDY_0912a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000668.1 861009 R 300267 CDS YP_402579.1 82776230 3799322 861552..862385 1 NC_007606.1 hypothetical protein 862385 3799322 SDY_0912 Shigella dysenteriae Sd197 hypothetical protein YP_402579.1 861552 D 300267 CDS YP_009000669.1 578793131 18262983 862481..862753 1 NC_007606.1 insertion element iso-IS1N protein InsA 862753 18262983 SDY_0913a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000669.1 862481 D 300267 CDS YP_402580.1 82776231 3799323 862959..863174 1 NC_007606.1 insertion element iso-IS1n protein InsB 863174 3799323 SDY_0913 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402580.1 862959 D 300267 CDS YP_402581.1 82776232 3799615 863152..864219 1 NC_007606.1 Code: NU; COG: COG3539; FimH-like protein 864219 3799615 SDY_0914 Shigella dysenteriae Sd197 FimH-like protein YP_402581.1 863152 D 300267 CDS YP_402582.1 82776233 3799616 864263..864772 1 NC_007606.1 Code: NU; COG: COG3539; fimbrial-like protein 864772 3799616 SDY_0915 Shigella dysenteriae Sd197 fimbrial-like protein YP_402582.1 864263 D 300267 CDS YP_402583.1 82776234 3799617 864732..865295 1 NC_007606.1 Code: NU; COG: COG3539; fimbrial-like protein 865295 3799617 SDY_0916 Shigella dysenteriae Sd197 fimbrial-like protein YP_402583.1 864732 D 300267 CDS YP_402584.1 82776235 3799618 865261..865998 1 NC_007606.1 Code: NU; COG: COG3121; pili assembly chaperone 865998 ycbF 3799618 ycbF Shigella dysenteriae Sd197 pili assembly chaperone YP_402584.1 865261 D 300267 CDS YP_402585.1 82776236 3799619 866109..867119 1 NC_007606.1 ''catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors''; dihydroorotate dehydrogenase 2 867119 pyrD 3799619 pyrD Shigella dysenteriae Sd197 dihydroorotate dehydrogenase 2 YP_402585.1 866109 D 300267 CDS YP_402586.1 82776237 3799620 867257..867835 1 NC_007606.1 hypothetical protein 867835 ycbW 3799620 ycbW Shigella dysenteriae Sd197 hypothetical protein YP_402586.1 867257 D 300267 CDS YP_402587.1 82776238 3799621 complement(867832..868941) 1 NC_007606.1 Code: R; COG: COG3217; hypothetical protein 868941 3799621 SDY_0920 Shigella dysenteriae Sd197 hypothetical protein YP_402587.1 867832 R 300267 CDS YP_402588.1 82776239 3799622 869185..871293 1 NC_007606.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 871293 rlmL 3799622 rlmL Shigella dysenteriae Sd197 23S rRNA m(2)G2445 methyltransferase YP_402588.1 869185 D 300267 CDS YP_402589.1 82776240 3799623 871305..873212 1 NC_007606.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 873212 uup 3799623 uup Shigella dysenteriae Sd197 ABC transporter ATPase YP_402589.1 871305 D 300267 CDS YP_402590.1 82776241 3799624 873342..874595 1 NC_007606.1 Code: S; COG: COG2995; paraquat-inducible protein A 874595 pqiA 3799624 pqiA Shigella dysenteriae Sd197 paraquat-inducible protein A YP_402590.1 873342 D 300267 CDS YP_402591.1 82776242 3799625 874600..876240 1 NC_007606.1 Code: R; COG: COG3008; paraquat-inducible protein B 876240 pqiB 3799625 pqiB Shigella dysenteriae Sd197 paraquat-inducible protein B YP_402591.1 874600 D 300267 CDS YP_402592.1 82776243 3799626 876252..876800 1 NC_007606.1 Code: S; COG: COG3009; hypothetical protein 876800 ymbA 3799626 ymbA Shigella dysenteriae Sd197 hypothetical protein YP_402592.1 876252 D 300267 CDS YP_402593.1 82776244 3799627 877056..877223 1 NC_007606.1 Code: J; COG: COG3130; ribosome modulation factor 877223 rmf 3799627 rmf Shigella dysenteriae Sd197 ribosome modulation factor YP_402593.1 877056 D 300267 CDS YP_402594.1 82776245 3799628 complement(877293..877811) 1 NC_007606.1 trans-2-decenoyl-ACP isomerase; ''catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP''; 3-hydroxydecanoyl-ACP dehydratase 877811 fabA 3799628 fabA Shigella dysenteriae Sd197 3-hydroxydecanoyl-ACP dehydratase YP_402594.1 877293 R 300267 CDS YP_402595.1 82776246 3799630 879851..880303 1 NC_007606.1 Code: S; COG: COG3120; hypothetical protein 880303 ycbG 3799630 ycbG Shigella dysenteriae Sd197 hypothetical protein YP_402595.1 879851 D 300267 CDS YP_402596.1 82776247 3799631 complement(880379..881431) 1 NC_007606.1 II*;G;d; ''OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d''; outer membrane protein OmpA 881431 ompA 3799631 ompA Shigella dysenteriae Sd197 outer membrane protein OmpA YP_402596.1 880379 R 300267 CDS YP_402597.1 82776248 3799632 882087..882389 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 882389 3799632 SDY_0931 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402597.1 882087 D 300267 CDS YP_402598.1 82776249 3799633 882530..883315 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 883315 3799633 SDY_0932 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402598.1 882530 D 300267 CDS YP_402599.1 82776250 3798487 883786..884415 1 NC_007606.1 Code: K; COG: COG3070; hypothetical protein 884415 3798487 SDY_0934 Shigella dysenteriae Sd197 hypothetical protein YP_402599.1 883786 D 300267 CDS YP_402600.1 82776251 3798488 complement(884378..886540) 1 NC_007606.1 Code: S; COG: COG1289; hypothetical protein 886540 3798488 SDY_0935 Shigella dysenteriae Sd197 hypothetical protein YP_402600.1 884378 R 300267 CDS YP_402601.1 82776252 3798489 complement(886550..886996) 1 NC_007606.1 Code: S; COG: COG3304; hypothetical protein 886996 yccF 3798489 yccF Shigella dysenteriae Sd197 hypothetical protein YP_402601.1 886550 R 300267 CDS YP_402602.1 82776253 3798490 887119..889173 1 NC_007606.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 889173 helD 3798490 helD Shigella dysenteriae Sd197 DNA helicase IV YP_402602.1 887119 D 300267 CDS YP_402603.2 161950141 3798491 complement(889205..889663) 1 NC_007606.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 889663 mgsA 3798491 mgsA Shigella dysenteriae Sd197 methylglyoxal synthase YP_402603.2 889205 R 300267 CDS YP_402604.1 82776255 3798492 complement(889759..890421) 1 NC_007606.1 Code: S; COG: COG3110; hypothetical protein 890421 3798492 SDY_0939 Shigella dysenteriae Sd197 hypothetical protein YP_402604.1 889759 R 300267 CDS YP_402605.1 82776256 3798493 890513..891007 1 NC_007606.1 Code: R; COG: COG1832; hypothetical protein 891007 3798493 SDY_0940 Shigella dysenteriae Sd197 hypothetical protein YP_402605.1 890513 D 300267 CDS YP_402606.1 82776257 3798494 complement(891052..891420) 1 NC_007606.1 Code: S; COG: COG3785; hypothetical protein 891420 yccV 3798494 yccV Shigella dysenteriae Sd197 hypothetical protein YP_402606.1 891052 R 300267 CDS YP_402607.1 82776258 3798495 complement(891427..892623) 1 NC_007606.1 Code: R; COG: COG1092; hypothetical protein 892623 yccW 3798495 yccW Shigella dysenteriae Sd197 hypothetical protein YP_402607.1 891427 R 300267 CDS YP_402608.1 82776259 3798496 892718..892996 1 NC_007606.1 Code: C; COG: COG1254; hypothetical protein 892996 3798496 SDY_0943 Shigella dysenteriae Sd197 hypothetical protein YP_402608.1 892718 D 300267 CDS YP_402609.2 161950140 3798497 complement(892993..893322) 1 NC_007606.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 893322 yccK 3798497 yccK Shigella dysenteriae Sd197 sulfur transfer protein TusE YP_402609.2 892993 R 300267 CDS YP_402610.1 82776261 3798498 complement(893413..894072) 1 NC_007606.1 Code: R; COG: COG0670; hypothetical protein 894072 yccA 3798498 yccA Shigella dysenteriae Sd197 hypothetical protein YP_402610.1 893413 R 300267 CDS YP_402611.1 82776262 3798500 894797..895915 1 NC_007606.1 Code: C; COG: COG1740; hydrogenase-1 small subunit 895915 hyaA 3798500 hyaA Shigella dysenteriae Sd197 hydrogenase-1 small subunit YP_402611.1 894797 D 300267 CDS YP_402613.1 82776264 3798502 897710..898417 1 NC_007606.1 Code: C; COG: COG1969; hydrogenase 1 b-type cytochrome subunit 898417 hyaC 3798502 hyaC Shigella dysenteriae Sd197 hydrogenase 1 b-type cytochrome subunit YP_402613.1 897710 D 300267 CDS YP_402614.1 82776265 3798503 898414..899001 1 NC_007606.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 899001 hyaD 3798503 hyaD Shigella dysenteriae Sd197 hydrogenase 1 maturation protease YP_402614.1 898414 D 300267 CDS YP_402615.1 82776266 3798504 898998..899396 1 NC_007606.1 involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 899396 hyaE 3798504 hyaE Shigella dysenteriae Sd197 hydrogenase-1 operon protein HyaE YP_402615.1 898998 D 300267 CDS YP_402616.1 82776267 3798729 900384..901928 1 NC_007606.1 Code: C; COG: COG1271; cytochrome bd-II oxidase subunit I 901928 appC 3798729 appC Shigella dysenteriae Sd197 cytochrome bd-II oxidase subunit I YP_402616.1 900384 D 300267 CDS YP_402617.1 82776268 3798730 901940..903076 1 NC_007606.1 Code: C; COG: COG1294; cytochrome bd-II oxidase subunit II 903076 appB 3798730 appB Shigella dysenteriae Sd197 cytochrome bd-II oxidase subunit II YP_402617.1 901940 D 300267 CDS YP_402618.1 82776269 3798731 903089..903181 1 NC_007606.1 Code: S; COG: COG4890; hypothetical protein 903181 yccB 3798731 yccB Shigella dysenteriae Sd197 hypothetical protein YP_402618.1 903089 D 300267 CDS YP_402619.1 82776270 3798732 903261..904565 1 NC_007606.1 pH 2.5 acid phosphatase; periplasmic; phosphoanhydride phosphorylase 904565 appA 3798732 appA Shigella dysenteriae Sd197 phosphoanhydride phosphorylase YP_402619.1 903261 D 300267 CDS YP_402620.1 82776271 3798733 complement(904685..906865) 1 NC_007606.1 Code: M; COG: COG3206; cryptic autophosphorylating protein tyrosine kinase Etk 906865 yccC 3798733 yccC Shigella dysenteriae Sd197 cryptic autophosphorylating protein tyrosine kinase Etk YP_402620.1 904685 R 300267 CDS YP_402621.2 161950139 3798734 complement(906885..907331) 1 NC_007606.1 ''Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk''; phosphotyrosine-protein phosphatase 907331 etp 3798734 etp Shigella dysenteriae Sd197 phosphotyrosine-protein phosphatase YP_402621.2 906885 R 300267 CDS YP_402622.1 82776273 3798735 complement(907319..908458) 1 NC_007606.1 Code: M; COG: COG1596; function in exopolysaccharide production 908458 yccZ 3798735 yccZ Shigella dysenteriae Sd197 function in exopolysaccharide production YP_402622.1 907319 R 300267 CDS YP_402623.1 82776274 3798736 complement(908504..910600) 1 NC_007606.1 hypothetical protein 910600 ymcA 3798736 ymcA Shigella dysenteriae Sd197 hypothetical protein YP_402623.1 908504 R 300267 CDS YP_402624.1 82776275 3798737 complement(910600..911346) 1 NC_007606.1 hypothetical protein 911346 ymcB 3798737 ymcB Shigella dysenteriae Sd197 hypothetical protein YP_402624.1 910600 R 300267 CDS YP_402625.1 82776276 3798738 complement(911343..911987) 1 NC_007606.1 regulator 911987 ymcC 3798738 ymcC Shigella dysenteriae Sd197 regulator YP_402625.1 911343 R 300267 CDS YP_402626.1 82776277 3798739 complement(912094..912417) 1 NC_007606.1 hypothetical protein 912417 ymcD 3798739 ymcD Shigella dysenteriae Sd197 hypothetical protein YP_402626.1 912094 R 300267 CDS YP_402627.1 82776278 3798740 complement(912841..913053) 1 NC_007606.1 Code: K; COG: COG1278; cold shock-like protein 913053 cspH 3798740 cspH Shigella dysenteriae Sd197 cold shock-like protein YP_402627.1 912841 R 300267 CDS YP_402628.1 82776279 3798741 complement(913330..913725) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 913725 3798741 SDY_0965 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402628.1 913330 R 300267 CDS YP_009000670.1 578793132 18262984 complement(913752..914024) 1 NC_007606.1 insertion element iso-IS1N protein InsA 914024 18262984 SDY_0965a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000670.1 913752 R 300267 CDS YP_402629.1 82776280 3798742 complement(914060..914620) 1 NC_007606.1 Code: C; COG: COG0348; hypothetical protein 914620 yccM 3798742 yccM Shigella dysenteriae Sd197 hypothetical protein YP_402629.1 914060 R 300267 CDS YP_402630.1 82776281 3798744 917512..918540 1 NC_007606.1 part of regulation of tor operon, periplasmic; periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 918540 torT 3798744 torT Shigella dysenteriae Sd197 TMAO reductase system periplasmic protein TorT YP_402630.1 917512 D 300267 CDS YP_402631.1 82776282 3798745 complement(918513..919205) 1 NC_007606.1 sensor TorS; response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 919205 torR 3798745 torR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator TorR YP_402631.1 918513 R 300267 CDS YP_402632.1 82776283 3797068 922989..923588 1 NC_007606.1 ''TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor''; chaperone protein TorD 923588 torD 3797068 torD Shigella dysenteriae Sd197 chaperone protein TorD YP_402632.1 922989 D 300267 CDS YP_402633.1 82776284 3797069 complement(923740..924045) 1 NC_007606.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 924045 yccD 3797069 yccD Shigella dysenteriae Sd197 chaperone-modulator protein CbpM YP_402633.1 923740 R 300267 CDS YP_402634.1 82776285 3797070 complement(924045..924965) 1 NC_007606.1 functions closely related to DnaJ; ''functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock''; curved DNA-binding protein CbpA 924965 cbpA 3797070 cbpA Shigella dysenteriae Sd197 curved DNA-binding protein CbpA YP_402634.1 924045 R 300267 CDS YP_009000671.1 578793133 18262985 925232..925504 1 NC_007606.1 insertion element iso-IS1N protein InsA 925504 18262985 SDY_0974a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000671.1 925232 D 300267 CDS YP_009000672.1 578793134 3797071 925531..925815 1 NC_007606.1 hypothetical protein 925815 3797071 SDY_0975 Shigella dysenteriae Sd197 hypothetical protein YP_009000672.1 925531 D 300267 CDS YP_402636.1 82776287 3797072 complement(925809..926186) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 926186 insB 3797072 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402636.1 925809 R 300267 CDS YP_402638.1 82776289 3797074 927854..929095 1 NC_007606.1 glucose-1-phosphatase/inositol phosphatase 929095 agp 3797074 agp Shigella dysenteriae Sd197 glucose-1-phosphatase/inositol phosphatase YP_402638.1 927854 D 300267 CDS YP_402639.1 82776290 3797075 complement(929133..929360) 1 NC_007606.1 hypothetical protein 929360 yccJ 3797075 yccJ Shigella dysenteriae Sd197 hypothetical protein YP_402639.1 929133 R 300267 CDS YP_402640.1 82776291 3797076 complement(929381..929977) 1 NC_007606.1 affects association of trp repressor and operator; stationary phase that binds TrpR repressor; TrpR binding protein WrbA 929977 wrbA 3797076 wrbA Shigella dysenteriae Sd197 TrpR binding protein WrbA YP_402640.1 929381 R 300267 CDS YP_009000673.1 578793135 18262986 930350..930523 1 NC_007606.1 hypothetical protein 930523 18262986 SDY_0980a Shigella dysenteriae Sd197 hypothetical protein YP_009000673.1 930350 D 300267 CDS YP_402641.1 82776292 3797077 complement(930606..932000) 1 NC_007606.1 Code: F; COG: COG2233; transport protein 932000 ycdG 3797077 ycdG Shigella dysenteriae Sd197 transport protein YP_402641.1 930606 R 300267 CDS YP_402642.1 82776293 3797078 complement(931955..932413) 1 NC_007606.1 Code: R; COG: COG1853; hypothetical protein 932413 3797078 SDY_0982 Shigella dysenteriae Sd197 hypothetical protein YP_402642.1 931955 R 300267 CDS YP_402643.1 82776294 3797079 complement(932460..933050) 1 NC_007606.1 Code: C; COG: COG0778; hypothetical protein 933050 3797079 SDY_0983 Shigella dysenteriae Sd197 hypothetical protein YP_402643.1 932460 R 300267 CDS YP_402644.1 82776295 3797080 complement(933060..933734) 1 NC_007606.1 Code: R; COG: COG0596; acetyltransferase 933734 3797080 SDY_0984 Shigella dysenteriae Sd197 acetyltransferase YP_402644.1 933060 R 300267 CDS YP_402645.1 82776296 3797081 complement(933742..934128) 1 NC_007606.1 Code: J; COG: COG0251; hypothetical protein 934128 3797081 SDY_0985 Shigella dysenteriae Sd197 hypothetical protein YP_402645.1 933742 R 300267 CDS YP_402646.1 82776297 3797083 complement(934832..935980) 1 NC_007606.1 Code: C; COG: COG2141; hypothetical protein 935980 3797083 SDY_0987 Shigella dysenteriae Sd197 hypothetical protein YP_402646.1 934832 R 300267 CDS YP_402647.1 82776298 3797084 936212..936850 1 NC_007606.1 Code: K; COG: COG1309; tet operon regulator 936850 ycdC 3797084 ycdC Shigella dysenteriae Sd197 tet operon regulator YP_402647.1 936212 D 300267 CDS YP_402648.1 82776299 3797125 941275..942783 1 NC_007606.1 Code: ER; COG: COG0591; major sodium/proline symporter 942783 putP 3797125 putP Shigella dysenteriae Sd197 major sodium/proline symporter YP_402648.1 941275 D 300267 CDS YP_402651.1 82776302 3797128 944740..945015 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 945015 insA 3797128 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402651.1 944740 D 300267 CDS YP_402652.1 82776303 3797129 945060..945437 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 945437 insB 3797129 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402652.1 945060 D 300267 CDS YP_009000674.1 578793136 18262987 complement(945759..946031) 1 NC_007606.1 insertion element iso-IS1N protein InsA 946031 18262987 SDY_0995a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000674.1 945759 R 300267 CDS YP_402654.1 82776305 3797132 946490..946879 1 NC_007606.1 2nd curli operon; chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 946879 csgE 3797132 csgE Shigella dysenteriae Sd197 curli assembly protein CsgE YP_402654.1 946490 D 300267 CDS YP_402655.1 82776306 3797133 946904..947320 1 NC_007606.1 2nd curli operon; nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 947320 csgF 3797133 csgF Shigella dysenteriae Sd197 curli assembly protein CsgF YP_402655.1 946904 D 300267 CDS YP_402656.1 82776307 3797134 947347..948180 1 NC_007606.1 2nd curli operon; Code: M; COG: COG1462; curli production assembly/transport protein 948180 csgG 3797134 csgG Shigella dysenteriae Sd197 curli production assembly/transport protein YP_402656.1 947347 D 300267 CDS YP_009000675.1 578793137 18262988 948272..948544 1 NC_007606.1 insertion element iso-IS1N protein InsA 948544 18262988 SDY_0999a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000675.1 948272 D 300267 CDS YP_402657.1 82776308 3797135 948571..948966 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 948966 3797135 SDY_1000 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402657.1 948571 D 300267 CDS YP_402658.1 82776309 3797136 complement(949018..949557) 1 NC_007606.1 hypothetical protein 949557 ycdZ 3797136 ycdZ Shigella dysenteriae Sd197 hypothetical protein YP_402658.1 949018 R 300267 CDS YP_402659.1 82776310 3797137 complement(949611..950165) 1 NC_007606.1 Code: R; COG: COG3381; oxidoreductase 950165 ycdY 3797137 ycdY Shigella dysenteriae Sd197 oxidoreductase YP_402659.1 949611 R 300267 CDS YP_402660.1 82776311 3797138 complement(950189..950926) 1 NC_007606.1 Code: ER; COG: COG1387; hydrolase 950926 ycdX 3797138 ycdX Shigella dysenteriae Sd197 hydrolase YP_402660.1 950189 R 300267 CDS YP_402661.1 82776312 3797139 complement(950981..951958) 1 NC_007606.1 Code: HE; COG: COG0111; dehydrogenase 951958 ycdW 3797139 ycdW Shigella dysenteriae Sd197 dehydrogenase YP_402661.1 950981 R 300267 CDS YP_402662.1 82776313 3797141 complement(952390..953232) 1 NC_007606.1 hypothetical protein 953232 3797141 SDY_1006 Shigella dysenteriae Sd197 hypothetical protein YP_402662.1 952390 R 300267 CDS YP_402663.1 82776314 3797142 complement(953329..953526) 1 NC_007606.1 hypothetical protein 953526 3797142 SDY_1007 Shigella dysenteriae Sd197 hypothetical protein YP_402663.1 953329 R 300267 CDS YP_402664.1 82776315 3797163 complement(953538..954029) 1 NC_007606.1 hypothetical protein 954029 3797163 SDY_1008 Shigella dysenteriae Sd197 hypothetical protein YP_402664.1 953538 R 300267 CDS YP_402665.1 82776316 3797164 complement(954026..954400) 1 NC_007606.1 hypothetical protein 954400 yeeV 3797164 yeeV Shigella dysenteriae Sd197 hypothetical protein YP_402665.1 954026 R 300267 CDS YP_402666.1 82776317 3797165 complement(954447..954824) 1 NC_007606.1 structural protein 954824 yeeU 3797165 yeeU Shigella dysenteriae Sd197 structural protein YP_402666.1 954447 R 300267 CDS YP_402667.1 82776318 3797166 complement(954874..955518) 1 NC_007606.1 hypothetical protein 955518 3797166 SDY_1011 Shigella dysenteriae Sd197 hypothetical protein YP_402667.1 954874 R 300267 CDS YP_402668.1 82776319 3797167 complement(955537..955758) 1 NC_007606.1 hypothetical protein 955758 yeeT 3797167 yeeT Shigella dysenteriae Sd197 hypothetical protein YP_402668.1 955537 R 300267 CDS YP_402669.1 82776320 3797168 complement(955827..956279) 1 NC_007606.1 Code: L; COG: COG2003; radC-like protein YeeS 956279 3797168 SDY_1013 Shigella dysenteriae Sd197 radC-like protein YeeS YP_402669.1 955827 R 300267 CDS YP_402670.1 82776321 3797169 complement(956295..956840) 1 NC_007606.1 hypothetical protein 956840 3797169 SDY_1014 Shigella dysenteriae Sd197 hypothetical protein YP_402670.1 956295 R 300267 CDS YP_402671.1 82776322 3797170 complement(957048..957869) 1 NC_007606.1 hypothetical protein 957869 3797170 SDY_1015 Shigella dysenteriae Sd197 hypothetical protein YP_402671.1 957048 R 300267 CDS YP_402672.1 82776323 3797171 complement(958263..958526) 1 NC_007606.1 hypothetical protein 958526 3797171 SDY_1016 Shigella dysenteriae Sd197 hypothetical protein YP_402672.1 958263 R 300267 CDS YP_402673.1 82776324 3797172 complement(959177..959644) 1 NC_007606.1 hypothetical protein 959644 3797172 SDY_1017 Shigella dysenteriae Sd197 hypothetical protein YP_402673.1 959177 R 300267 CDS YP_402674.1 82776325 3797173 960581..961423 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 961423 3797173 SDY_1018 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402674.1 960581 D 300267 CDS YP_402675.2 161950138 3797174 complement(961257..962162) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 962162 3797174 SDY_1019 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402675.2 961257 R 300267 CDS YP_402676.1 82776327 3797175 complement(962120..962485) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 962485 3797175 SDY_1020 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402676.1 962120 R 300267 CDS YP_402677.1 82776328 3797176 complement(963197..963592) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 963592 3797176 SDY_1021 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402677.1 963197 R 300267 CDS YP_009000676.1 578793138 18262989 complement(963619..963891) 1 NC_007606.1 insertion element iso-IS1N protein InsA 963891 18262989 SDY_1021a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000676.1 963619 R 300267 CDS YP_402678.1 82776329 3797177 963985..966162 1 NC_007606.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 966162 iroN 3797177 iroN Shigella dysenteriae Sd197 outer membrane receptor FepA YP_402678.1 963985 D 300267 CDS YP_402679.1 82776330 3797178 complement(966207..967163) 1 NC_007606.1 Code: R; COG: COG2819; hypothetical protein 967163 iroE 3797178 iroE Shigella dysenteriae Sd197 hypothetical protein YP_402679.1 966207 R 300267 CDS YP_402680.1 82776331 3797179 complement(967248..968477) 1 NC_007606.1 Code: P; COG: COG2382; ferric enterochelin esterase 968477 iroD 3797179 iroD Shigella dysenteriae Sd197 ferric enterochelin esterase YP_402680.1 967248 R 300267 CDS YP_402681.1 82776332 3797180 complement(968581..972240) 1 NC_007606.1 Code: V; COG: COG1132; ABC transporter protein 972240 iroC 3797180 iroC Shigella dysenteriae Sd197 ABC transporter protein YP_402681.1 968581 R 300267 CDS YP_402682.1 82776333 3797181 complement(972380..973495) 1 NC_007606.1 Code: GC; COG: COG1819; glycosyl transferase 973495 iroB 3797181 iroB Shigella dysenteriae Sd197 glycosyl transferase YP_402682.1 972380 R 300267 CDS YP_402686.1 82776337 3796806 complement(975122..975424) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 975424 3796806 SDY_1030 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402686.1 975122 R 300267 CDS YP_402687.1 82776338 3796807 complement(976057..976452) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 976452 3796807 SDY_1031 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402687.1 976057 R 300267 CDS YP_009000677.1 578793139 18262990 complement(976479..976751) 1 NC_007606.1 insertion element iso-IS1N protein InsA 976751 18262990 SDY_1031a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000677.1 976479 R 300267 CDS YP_402689.1 82776340 3796809 complement(977103..977753) 1 NC_007606.1 Code: R; COG: COG3443; hypothetical protein 977753 3796809 SDY_1033 Shigella dysenteriae Sd197 hypothetical protein YP_402689.1 977103 R 300267 CDS YP_402690.1 82776341 3796810 complement(978010..978645) 1 NC_007606.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 978645 3796810 SDY_1034 Shigella dysenteriae Sd197 sulfite oxidase subunit YedZ YP_402690.1 978010 R 300267 CDS YP_402691.1 82776342 3796811 complement(978646..979650) 1 NC_007606.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 979650 3796811 SDY_1035 Shigella dysenteriae Sd197 sulfite oxidase subunit YedY YP_402691.1 978646 R 300267 CDS YP_402692.1 82776343 3796812 complement(979876..980271) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 980271 3796812 SDY_1036 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402692.1 979876 R 300267 CDS YP_009000678.1 578793140 18262991 complement(980298..980570) 1 NC_007606.1 insertion element iso-IS1N protein InsA 980570 18262991 SDY_1038a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000678.1 980298 R 300267 CDS YP_402694.1 82776345 3796814 complement(980610..980936) 1 NC_007606.1 Code: R; COG: COG2351; hypothetical protein 980936 3796814 SDY_1038 Shigella dysenteriae Sd197 hypothetical protein YP_402694.1 980610 R 300267 CDS YP_402695.2 161950137 3796815 981069..981719 1 NC_007606.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulator YedW 981719 yedW 3796815 yedW Shigella dysenteriae Sd197 transcriptional regulator YedW YP_402695.2 981069 D 300267 CDS YP_402696.1 82776347 3796816 complement(981694..982089) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 982089 3796816 SDY_1040 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402696.1 981694 R 300267 CDS YP_009000679.1 578793141 18262992 complement(982116..982388) 1 NC_007606.1 insertion element iso-IS1N protein InsA 982388 18262992 SDY_1042a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000679.1 982116 R 300267 CDS YP_402698.1 82776349 3796818 982511..982894 1 NC_007606.1 hypothetical protein 982894 3796818 SDY_1042 Shigella dysenteriae Sd197 hypothetical protein YP_402698.1 982511 D 300267 CDS YP_402701.1 82776352 3796821 983685..985103 1 NC_007606.1 Code: L; COG: COG0270; DNA cytosine methylase 985103 dcm 3796821 dcm Shigella dysenteriae Sd197 DNA cytosine methylase YP_402701.1 983685 D 300267 CDS YP_402702.1 82776353 3796822 985084..985554 1 NC_007606.1 Code: L; COG: COG3727; DNA mismatch endonuclease 985554 vsr 3796822 vsr Shigella dysenteriae Sd197 DNA mismatch endonuclease YP_402702.1 985084 D 300267 CDS YP_402703.1 82776354 3796728 complement(985543..986463) 1 NC_007606.1 Code: GER; COG: COG0697; hypothetical protein 986463 yedA 3796728 yedA Shigella dysenteriae Sd197 hypothetical protein YP_402703.1 985543 R 300267 CDS YP_402704.1 82776355 3796729 986636..987553 1 NC_007606.1 Code: S; COG: COG2354; hypothetical protein 987553 yedI 3796729 yedI Shigella dysenteriae Sd197 hypothetical protein YP_402704.1 986636 D 300267 CDS YP_402705.1 82776356 3796730 987632..987814 1 NC_007606.1 Code: S; COG: COG5475; hypothetical protein 987814 3796730 SDY_1049 Shigella dysenteriae Sd197 hypothetical protein YP_402705.1 987632 D 300267 CDS YP_402706.1 82776357 3796731 988003..989679 1 NC_007606.1 Code: T; COG: COG2199; hypothetical protein 989679 3796731 SDY_1050 Shigella dysenteriae Sd197 hypothetical protein YP_402706.1 988003 D 300267 CDS YP_402707.1 82776358 3796732 complement(989676..990491) 1 NC_007606.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 990491 3796732 SDY_1051 Shigella dysenteriae Sd197 mannosyl-3-phosphoglycerate phosphatase YP_402707.1 989676 R 300267 CDS YP_402708.1 82776359 3796733 complement(990789..991031) 1 NC_007606.1 hypothetical protein 991031 3796733 SDY_1052 Shigella dysenteriae Sd197 hypothetical protein YP_402708.1 990789 R 300267 CDS YP_402709.1 82776360 3796734 991165..991353 1 NC_007606.1 hypothetical protein 991353 dsrB 3796734 dsrB Shigella dysenteriae Sd197 hypothetical protein YP_402709.1 991165 D 300267 CDS YP_009000680.1 578793142 18262993 991693..991965 1 NC_007606.1 insertion element iso-IS1N protein InsA 991965 18262993 SDY_1053a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000680.1 991693 D 300267 CDS YP_402710.1 82776361 3796735 991992..992387 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 992387 3796735 SDY_1054 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402710.1 991992 D 300267 CDS YP_402711.1 82776362 3796736 complement(992462..992839) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 992839 insB 3796736 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402711.1 992462 R 300267 CDS YP_402712.1 82776363 3796737 complement(992884..993159) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 993159 insA 3796737 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402712.1 992884 R 300267 CDS YP_402713.1 82776364 3796738 complement(993493..993888) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 993888 3796738 SDY_1057 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402713.1 993493 R 300267 CDS YP_009000681.1 578793143 18262994 complement(993915..994187) 1 NC_007606.1 insertion element iso-IS1N protein InsA 994187 18262994 SDY_1057a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000681.1 993915 R 300267 CDS YP_402716.2 578793144 3796741 996113..996769 1 NC_007606.1 Code: QR; COG: COG0500; hypothetical protein 996769 3796741 SDY_1060 Shigella dysenteriae Sd197 hypothetical protein YP_402716.2 996113 D 300267 CDS YP_009000682.1 578793145 18262995 997133..997405 1 NC_007606.1 insertion element iso-IS1N protein InsA 997405 18262995 SDY_1061a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000682.1 997133 D 300267 CDS YP_402717.1 82776368 3796742 997432..997827 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 997827 3796742 SDY_1061 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402717.1 997432 D 300267 CDS YP_402719.1 82776370 3796744 complement(999324..1000109) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1000109 3796744 SDY_1063 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402719.1 999324 R 300267 CDS YP_402720.1 82776371 3796745 complement(1000250..1000552) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1000552 3796745 SDY_1064 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402720.1 1000250 R 300267 CDS YP_402721.1 82776372 3796746 complement(1001080..1002129) 1 NC_007606.1 tail fiber protein 1002129 3796746 SDY_1065 Shigella dysenteriae Sd197 tail fiber protein YP_402721.1 1001080 R 300267 CDS YP_402722.1 82776373 3796747 complement(1002153..1002641) 1 NC_007606.1 tail fiber assembly protein 1002641 3796747 SDY_1066 Shigella dysenteriae Sd197 tail fiber assembly protein YP_402722.1 1002153 R 300267 CDS YP_402723.1 82776374 3799923 complement(1002701..1002814) 1 NC_007606.1 phage tail fiber protein 1002814 3799923 SDY_1067 Shigella dysenteriae Sd197 phage tail fiber protein YP_402723.1 1002701 R 300267 CDS YP_402724.1 82776375 3799924 1002853..1003155 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1003155 3799924 SDY_1068 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402724.1 1002853 D 300267 CDS YP_402725.1 82776376 3799925 1003296..1004009 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1004009 3799925 SDY_1069 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402725.1 1003296 D 300267 CDS YP_402726.1 82776377 3799926 complement(1004265..1004660) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1004660 3799926 SDY_1070 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402726.1 1004265 R 300267 CDS YP_009000683.1 578793146 18262996 complement(1004687..1004959) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1004959 18262996 SDY_1069a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000683.1 1004687 R 300267 CDS YP_402727.1 82776378 3799928 1005276..1006112 1 NC_007606.1 Code: S; COG: COG3228; hypothetical protein 1006112 3799928 SDY_1072 Shigella dysenteriae Sd197 hypothetical protein YP_402727.1 1005276 D 300267 CDS YP_402728.1 82776379 3799930 1006574..1006978 1 NC_007606.1 hypothetical protein 1006978 3799930 SDY_1074 Shigella dysenteriae Sd197 hypothetical protein YP_402728.1 1006574 D 300267 CDS YP_402729.1 82776380 3799931 1007089..1007865 1 NC_007606.1 hypothetical protein 1007865 3799931 SDY_1075 Shigella dysenteriae Sd197 hypothetical protein YP_402729.1 1007089 D 300267 CDS YP_402730.1 82776381 3799932 1007889..1008107 1 NC_007606.1 hypothetical protein 1008107 3799932 SDY_1076 Shigella dysenteriae Sd197 hypothetical protein YP_402730.1 1007889 D 300267 CDS YP_402731.1 82776382 3799933 1008318..1008851 1 NC_007606.1 hypothetical protein 1008851 3799933 SDY_1077 Shigella dysenteriae Sd197 hypothetical protein YP_402731.1 1008318 D 300267 CDS YP_402732.2 161950136 3799934 complement(1008822..1009727) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1009727 3799934 SDY_1078 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402732.2 1008822 R 300267 CDS YP_402733.1 82776384 3799935 complement(1009685..1010050) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1010050 3799935 SDY_1079 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402733.1 1009685 R 300267 CDS YP_402735.1 82776386 3799937 complement(1011244..1011639) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1011639 3799937 SDY_1081 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402735.1 1011244 R 300267 CDS YP_009000684.1 578793147 18262997 complement(1011666..1011938) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1011938 18262997 SDY_1083a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000684.1 1011666 R 300267 CDS YP_402737.1 82776388 3799939 complement(1012083..1012478) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1012478 3799939 SDY_1083 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402737.1 1012083 R 300267 CDS YP_009000685.1 578793148 18262998 complement(1012505..1012777) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1012777 18262998 SDY_1084a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000685.1 1012505 R 300267 CDS YP_402738.1 82776389 3797826 complement(1012902..1013573) 1 NC_007606.1 Code: S; COG: COG2135; hypothetical protein 1013573 yedK 3797826 yedK Shigella dysenteriae Sd197 hypothetical protein YP_402738.1 1012902 R 300267 CDS YP_402739.1 82776390 3797827 complement(1013682..1013915) 1 NC_007606.1 Code: O; COG: COG0425; hypothetical protein 1013915 yedF 3797827 yedF Shigella dysenteriae Sd197 hypothetical protein YP_402739.1 1013682 R 300267 CDS YP_402740.1 82776391 3797828 complement(1013912..1015117) 1 NC_007606.1 Code: R; COG: COG2391; inner membrane protein 1015117 yedE 3797828 yedE Shigella dysenteriae Sd197 inner membrane protein YP_402740.1 1013912 R 300267 CDS YP_402741.1 82776392 3797829 1015304..1015717 1 NC_007606.1 hypothetical protein 1015717 yedD 3797829 yedD Shigella dysenteriae Sd197 hypothetical protein YP_402741.1 1015304 D 300267 CDS YP_402742.1 82776393 3797830 complement(1015751..1017238) 1 NC_007606.1 ''converts 1,4-alpha-D-glucans to maltodextrin''; alpha-amylase 1017238 amyA 3797830 amyA Shigella dysenteriae Sd197 alpha-amylase YP_402742.1 1015751 R 300267 CDS YP_402743.1 82776394 3797832 complement(1017681..1018091) 1 NC_007606.1 flagellar biosynthesis; RflA activity; flagellin specific chaperone; flagellar protein FliS 1018091 fliS 3797832 fliS Shigella dysenteriae Sd197 flagellar protein FliS YP_402743.1 1017681 R 300267 CDS YP_402744.1 82776395 3797833 complement(1018116..1019513) 1 NC_007606.1 flagellar biosynthesis; enables filament assembly; involved in flagellin assembly; flagellar capping protein 1019513 fliD 3797833 fliD Shigella dysenteriae Sd197 flagellar capping protein YP_402744.1 1018116 R 300267 CDS YP_402745.1 82776396 3797835 complement(1021134..1021511) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1021511 insB 3797835 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402745.1 1021134 R 300267 CDS YP_402746.1 82776397 3797836 complement(1021556..1021831) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1021831 insA 3797836 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402746.1 1021556 R 300267 CDS YP_402747.1 82776398 3797837 1022538..1023257 1 NC_007606.1 flagellar biosynthesis; regulation of flagellar operons; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 1023257 fliA 3797837 fliA Shigella dysenteriae Sd197 flagellar biosynthesis sigma factor YP_402747.1 1022538 D 300267 CDS YP_402748.1 82776399 3797838 1023267..1023854 1 NC_007606.1 ''expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence''; flagella biosynthesis protein FliZ 1023854 fliZ 3797838 fliZ Shigella dysenteriae Sd197 flagella biosynthesis protein FliZ YP_402748.1 1023267 D 300267 CDS YP_402749.1 82776400 3797839 1023942..1024742 1 NC_007606.1 Code: ET; COG: COG0834; cystine transporter subunit 1024742 fliY 3797839 fliY Shigella dysenteriae Sd197 cystine transporter subunit YP_402749.1 1023942 D 300267 CDS YP_402750.2 161950135 3797840 1024847..1025833 1 NC_007606.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1025833 yedO 3797840 yedO Shigella dysenteriae Sd197 D-cysteine desulfhydrase YP_402750.2 1024847 D 300267 CDS YP_402751.1 82776402 3797841 1025848..1026516 1 NC_007606.1 formerly yecC; Code: E; COG: COG0765; transport system permease 1026516 yecS 3797841 yecS Shigella dysenteriae Sd197 transport system permease YP_402751.1 1025848 D 300267 CDS YP_402752.1 82776403 3797842 1026513..1027265 1 NC_007606.1 Code: E; COG: COG1126; amino-acid ABC transporter ATP-binding protein YecC 1027265 yecC 3797842 yecC Shigella dysenteriae Sd197 amino-acid ABC transporter ATP-binding protein YecC YP_402752.1 1026513 D 300267 CDS YP_009000686.1 578793149 18262999 1028108..1028380 1 NC_007606.1 insertion element iso-IS1N protein InsA 1028380 18262999 SDY_1101a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000686.1 1028108 D 300267 CDS YP_402753.1 82776404 3797844 1028407..1028802 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1028802 3797844 SDY_1102 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402753.1 1028407 D 300267 CDS YP_402754.1 82776405 3797845 complement(1029059..1029283) 1 NC_007606.1 hypothetical protein 1029283 yecF 3797845 yecF Shigella dysenteriae Sd197 hypothetical protein YP_402754.1 1029059 R 300267 CDS YP_402755.1 82776406 3795445 1029742..1030398 1 NC_007606.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 1030398 uvrY 3795445 uvrY Shigella dysenteriae Sd197 response regulator YP_402755.1 1029742 D 300267 CDS YP_402756.2 161950134 3795446 1030395..1032122 1 NC_007606.1 repair of UV damage to DNA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1032122 uvrC 3795446 uvrC Shigella dysenteriae Sd197 excinuclease ABC subunit C YP_402756.2 1030395 D 300267 CDS YP_402757.1 82776408 3795447 1032286..1032834 1 NC_007606.1 Code: I; COG: COG0558; phosphatidylglycerophosphate synthetase 1032834 pgsA 3795447 pgsA Shigella dysenteriae Sd197 phosphatidylglycerophosphate synthetase YP_402757.1 1032286 D 300267 CDS YP_402758.1 82776409 3795451 1033484..1034149 1 NC_007606.1 Code: R; COG: COG3318; hypothetical protein 1034149 yecA 3795451 yecA Shigella dysenteriae Sd197 hypothetical protein YP_402758.1 1033484 D 300267 CDS YP_402759.1 82776410 3795452 complement(1034211..1035422) 1 NC_007606.1 Code: E; COG: COG0814; tyrosine-specific transporter 1035422 tyrP 3795452 tyrP Shigella dysenteriae Sd197 tyrosine-specific transporter YP_402759.1 1034211 R 300267 CDS YP_402760.1 82776411 3795453 1035614..1035853 1 NC_007606.1 hypothetical protein 1035853 yecH 3795453 yecH Shigella dysenteriae Sd197 hypothetical protein YP_402760.1 1035614 D 300267 CDS YP_402761.1 82776412 3795454 complement(1035891..1036388) 1 NC_007606.1 iron storage protein; cytoplasmic iron storage protein; ferritin 1036388 ftn 3795454 ftn Shigella dysenteriae Sd197 ferritin YP_402761.1 1035891 R 300267 CDS YP_402762.1 82776413 3795455 complement(1036559..1036882) 1 NC_007606.1 hypothetical protein 1036882 3795455 SDY_1114 Shigella dysenteriae Sd197 hypothetical protein YP_402762.1 1036559 R 300267 CDS YP_402763.1 82776414 3795456 complement(1037093..1037488) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1037488 3795456 SDY_1115 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402763.1 1037093 R 300267 CDS YP_009000687.1 578793150 18263000 complement(1037515..1037787) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1037787 18263000 SDY_1115a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000687.1 1037515 R 300267 CDS YP_402764.1 82776415 3795457 1038290..1038793 1 NC_007606.1 Code: P; COG: COG1528; ferritin 1038793 yecI 3795457 yecI Shigella dysenteriae Sd197 ferritin YP_402764.1 1038290 D 300267 CDS YP_402765.1 82776416 3795458 complement(1038872..1039123) 1 NC_007606.1 hypothetical protein 1039123 3795458 SDY_1117 Shigella dysenteriae Sd197 hypothetical protein YP_402765.1 1038872 R 300267 CDS YP_402766.1 82776418 3795460 complement(1039412..1039807) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1039807 3795460 SDY_1119 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402766.1 1039412 R 300267 CDS YP_402768.1 82776419 3799748 1040222..1041211 1 NC_007606.1 Code: G; COG: COG1879; L-arabinose-binding protein 1041211 araF 3799748 araF Shigella dysenteriae Sd197 L-arabinose-binding protein YP_402768.1 1040222 D 300267 CDS YP_402769.1 82776420 3799749 1041281..1042795 1 NC_007606.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose ABC transporter ATP-binding protein 1042795 araG 3799749 araG Shigella dysenteriae Sd197 L-arabinose ABC transporter ATP-binding protein YP_402769.1 1041281 D 300267 CDS YP_402770.1 82776421 3799750 1042807..1043796 1 NC_007606.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose ABC transporter permease 1043796 araH 3799750 araH Shigella dysenteriae Sd197 L-arabinose ABC transporter permease YP_402770.1 1042807 D 300267 CDS YP_402771.1 82776422 3799751 1044340..1044642 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1044642 3799751 SDY_1123 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402771.1 1044340 D 300267 CDS YP_402773.1 82776424 3799753 complement(1046365..1046706) 1 NC_007606.1 hypothetical protein 1046706 3799753 SDY_1125 Shigella dysenteriae Sd197 hypothetical protein YP_402773.1 1046365 R 300267 CDS YP_402775.1 82776426 3799755 complement(1047596..1047970) 1 NC_007606.1 Code: R; COG: COG2372; hypothetical protein 1047970 3799755 SDY_1127 Shigella dysenteriae Sd197 hypothetical protein YP_402775.1 1047596 R 300267 CDS YP_402776.1 82776427 3799756 1048109..1048339 1 NC_007606.1 DNA polymerase III subunit theta 1048339 holE 3799756 holE Shigella dysenteriae Sd197 DNA polymerase III subunit theta YP_402776.1 1048109 D 300267 CDS YP_402777.1 82776428 3799757 1048441..1049097 1 NC_007606.1 Code: R; COG: COG0388; hypothetical protein 1049097 3799757 SDY_1129 Shigella dysenteriae Sd197 hypothetical protein YP_402777.1 1048441 D 300267 CDS YP_402778.1 82776429 3799758 1049121..1049783 1 NC_007606.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1049783 3799758 SDY_1130 Shigella dysenteriae Sd197 exodeoxyribonuclease X YP_402778.1 1049121 D 300267 CDS YP_402779.1 82776430 3799759 complement(1049780..1051840) 1 NC_007606.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1051840 ptrB 3799759 ptrB Shigella dysenteriae Sd197 protease 2 YP_402779.1 1049780 R 300267 CDS YP_402780.1 82776431 3799760 complement(1052049..1052708) 1 NC_007606.1 Code: S; COG: COG2979; hypothetical protein 1052708 yebE 3799760 yebE Shigella dysenteriae Sd197 hypothetical protein YP_402780.1 1052049 R 300267 CDS YP_402781.1 82776432 3799761 complement(1053032..1053400) 1 NC_007606.1 secreted protein; unknown function; hypothetical protein 1053400 yebF 3799761 yebF Shigella dysenteriae Sd197 hypothetical protein YP_402781.1 1053032 R 300267 CDS YP_402782.1 82776433 3799762 complement(1053455..1053745) 1 NC_007606.1 Code: S; COG: COG3141; DNA damage-inducible protein YebG 1053745 yebG 3799762 yebG Shigella dysenteriae Sd197 DNA damage-inducible protein YebG YP_402782.1 1053455 R 300267 CDS YP_402783.1 82776434 3799763 1053879..1055057 1 NC_007606.1 ''non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis''; phosphoribosylglycinamide formyltransferase 2 1055057 purT 3799763 purT Shigella dysenteriae Sd197 phosphoribosylglycinamide formyltransferase 2 YP_402783.1 1053879 D 300267 CDS YP_402784.1 82776435 3799764 complement(1055113..1055754) 1 NC_007606.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1055754 eda 3799764 eda Shigella dysenteriae Sd197 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_402784.1 1055113 R 300267 CDS YP_402785.1 82776436 3799765 complement(1055791..1057602) 1 NC_007606.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1057602 edd 3799765 edd Shigella dysenteriae Sd197 phosphogluconate dehydratase YP_402785.1 1055791 R 300267 CDS YP_402786.1 82776437 3799766 complement(1057837..1059312) 1 NC_007606.1 ''catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate''; glucose-6-phosphate 1-dehydrogenase 1059312 zwf 3799766 zwf Shigella dysenteriae Sd197 glucose-6-phosphate 1-dehydrogenase YP_402786.1 1057837 R 300267 CDS YP_402789.1 82776440 3795462 1060646..1062088 1 NC_007606.1 glucose stimulated; catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1062088 pykA 3795462 pykA Shigella dysenteriae Sd197 pyruvate kinase YP_402789.1 1060646 D 300267 CDS YP_402790.1 82776441 3795463 complement(1062219..1063190) 1 NC_007606.1 heat shock protein; ''Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA''; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1063190 msbB 3795463 msbB Shigella dysenteriae Sd197 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_402790.1 1062219 R 300267 CDS YP_402791.2 161950133 3795464 complement(1063310..1064632) 1 NC_007606.1 Code: M; COG: COG0739; hypothetical protein 1064632 yebA 3795464 yebA Shigella dysenteriae Sd197 hypothetical protein YP_402791.2 1063310 R 300267 CDS YP_402792.2 161950132 3795465 complement(1064648..1065580) 1 NC_007606.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc ABC transporter substrate-binding protein 1065580 znuA 3795465 znuA Shigella dysenteriae Sd197 high-affinity zinc ABC transporter substrate-binding protein YP_402792.2 1064648 R 300267 CDS YP_402793.1 82776444 3795466 1065659..1066414 1 NC_007606.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc ABC transporter ATPase 1066414 znuC 3795466 znuC Shigella dysenteriae Sd197 high-affinity zinc ABC transporter ATPase YP_402793.1 1065659 D 300267 CDS YP_402794.1 82776445 3795467 1066411..1067196 1 NC_007606.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc ABC transporter permease 1067196 znuB 3795467 znuB Shigella dysenteriae Sd197 high-affinity zinc ABC transporter permease YP_402794.1 1066411 D 300267 CDS YP_402795.1 82776446 3795468 complement(1067343..1068353) 1 NC_007606.1 branch migration; repair; promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1068353 ruvB 3795468 ruvB Shigella dysenteriae Sd197 Holliday junction DNA helicase RuvB YP_402795.1 1067343 R 300267 CDS YP_402796.1 82776447 3795469 complement(1068362..1068973) 1 NC_007606.1 branch migration; repair; plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1068973 ruvA 3795469 ruvA Shigella dysenteriae Sd197 Holliday junction DNA helicase RuvA YP_402796.1 1068362 R 300267 CDS YP_402797.2 161950131 3795470 1069248..1069850 1 NC_007606.1 hypothetical protein 1069850 yebB 3795470 yebB Shigella dysenteriae Sd197 hypothetical protein YP_402797.2 1069248 D 300267 CDS YP_402798.1 82776449 3795471 complement(1069852..1070373) 1 NC_007606.1 resolution of structures; repair; endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1070373 ruvC 3795471 ruvC Shigella dysenteriae Sd197 Holliday junction resolvase YP_402798.1 1069852 R 300267 CDS YP_402799.1 82776450 3795472 complement(1070408..1071148) 1 NC_007606.1 Code: S; COG: COG0217; hypothetical protein 1071148 yebC 3795472 yebC Shigella dysenteriae Sd197 hypothetical protein YP_402799.1 1070408 R 300267 CDS YP_402800.1 82776451 3795473 complement(1071177..1071629) 1 NC_007606.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1071629 ntpA 3795473 ntpA Shigella dysenteriae Sd197 dATP pyrophosphohydrolase YP_402800.1 1071177 R 300267 CDS YP_402801.1 82776452 3795474 complement(1071747..1073519) 1 NC_007606.1 ''catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes''; aspartyl-tRNA synthetase 1073519 aspS 3795474 aspS Shigella dysenteriae Sd197 aspartyl-tRNA synthetase YP_402801.1 1071747 R 300267 CDS YP_402802.1 82776453 3795475 1073829..1074083 1 NC_007606.1 hypothetical protein 1074083 3795475 SDY_1154 Shigella dysenteriae Sd197 hypothetical protein YP_402802.1 1073829 D 300267 CDS YP_402803.1 82776454 3795476 1074275..1075471 1 NC_007606.1 Code: L; COG: COG3547; insertion element IS110 transposase 1075471 3795476 SDY_1155 Shigella dysenteriae Sd197 insertion element IS110 transposase YP_402803.1 1074275 D 300267 CDS YP_402804.1 82776455 3795477 1075974..1076249 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1076249 insA 3795477 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402804.1 1075974 D 300267 CDS YP_402806.1 82776457 3795479 1077771..1078073 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1078073 3795479 SDY_1158 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402806.1 1077771 D 300267 CDS YP_402809.1 82776460 3796825 complement(1079466..1079918) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 4 protein InsB 1079918 insB 3796825 insB Shigella dysenteriae Sd197 insertion element IS1 4 protein InsB YP_402809.1 1079466 R 300267 CDS YP_402810.2 161950130 3796826 complement(1079903..1080808) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1080808 3796826 SDY_1162 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402810.2 1079903 R 300267 CDS YP_402811.1 82776462 3796827 complement(1080766..1081131) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1081131 3796827 SDY_1163 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402811.1 1080766 R 300267 CDS YP_402812.1 82776463 3796828 complement(1081224..1081499) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1081499 insA 3796828 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402812.1 1081224 R 300267 CDS YP_402813.1 82776464 3796829 complement(1081860..1082255) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1082255 3796829 SDY_1165 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402813.1 1081860 R 300267 CDS YP_402814.1 82776465 3796830 complement(1082590..1083207) 1 NC_007606.1 hypothetical protein 1083207 3796830 SDY_1166 Shigella dysenteriae Sd197 hypothetical protein YP_402814.1 1082590 R 300267 CDS YP_402815.1 82776466 3796831 1083311..1083658 1 NC_007606.1 hypothetical protein 1083658 3796831 SDY_1167 Shigella dysenteriae Sd197 hypothetical protein YP_402815.1 1083311 D 300267 CDS YP_402816.2 161950129 3796832 1083711..1084106 1 NC_007606.1 Code: R; COG: COG3788; hypothetical protein 1084106 yecN 3796832 yecN Shigella dysenteriae Sd197 hypothetical protein YP_402816.2 1083711 D 300267 CDS YP_402817.1 82776468 3796833 1084147..1084890 1 NC_007606.1 Code: QR; COG: COG0500; hypothetical protein 1084890 yecO 3796833 yecO Shigella dysenteriae Sd197 hypothetical protein YP_402817.1 1084147 D 300267 CDS YP_402818.1 82776469 3796834 1084887..1085858 1 NC_007606.1 Code: QR; COG: COG0500; S-adenosyl-L-methionine-dependent methyltransferase 1085858 yecP 3796834 yecP Shigella dysenteriae Sd197 S-adenosyl-L-methionine-dependent methyltransferase YP_402818.1 1084887 D 300267 CDS YP_402819.1 82776470 3796835 complement(1086023..1088383) 1 NC_007606.1 Code: C; COG: COG0243; biotin sulfoxide reductase 1088383 bisZ 3796835 bisZ Shigella dysenteriae Sd197 biotin sulfoxide reductase YP_402819.1 1086023 R 300267 CDS YP_009000688.1 578793151 18263001 complement(1089317..1089589) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1089589 18263001 SDY_1174a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000688.1 1089317 R 300267 CDS YP_402822.1 82776473 3796838 complement(1090044..1090439) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1090439 3796838 SDY_1174 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402822.1 1090044 R 300267 CDS YP_009000689.1 578793152 18263002 complement(1090466..1090738) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1090738 18263002 SDY_1176a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000689.1 1090466 R 300267 CDS YP_402823.1 82776474 3796840 complement(1091345..1091740) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1091740 3796840 SDY_1176 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402823.1 1091345 R 300267 CDS YP_009000690.1 578793153 18263003 complement(1091767..1092039) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1092039 18263003 SDY_1178a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000690.1 1091767 R 300267 CDS YP_402825.1 82776476 3796842 complement(1092199..1092945) 1 NC_007606.1 Code: P; COG: COG3142; copper homeostasis protein CutC 1092945 cutC 3796842 cutC Shigella dysenteriae Sd197 copper homeostasis protein CutC YP_402825.1 1092199 R 300267 CDS YP_402826.1 82776477 3795480 complement(1092959..1093531) 1 NC_007606.1 Code: S; COG: COG3102; hypothetical protein 1093531 yecM 3795480 yecM Shigella dysenteriae Sd197 hypothetical protein YP_402826.1 1092959 R 300267 CDS YP_402827.1 82776478 3795481 1093741..1095474 1 NC_007606.1 ''catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase''; arginyl-tRNA synthetase 1095474 argS 3795481 argS Shigella dysenteriae Sd197 arginyl-tRNA synthetase YP_402827.1 1093741 D 300267 CDS YP_402828.1 82776479 3795482 1095709..1095984 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 1095984 insA 3795482 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_402828.1 1095709 D 300267 CDS YP_402829.1 82776480 3795483 1096029..1096406 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1096406 insB 3795483 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402829.1 1096029 D 300267 CDS YP_402830.1 82776481 3795484 complement(1097038..1097430) 1 NC_007606.1 flagellar protein 1097430 flhE 3795484 flhE Shigella dysenteriae Sd197 flagellar protein YP_402830.1 1097038 R 300267 CDS YP_402831.1 82776482 3795486 complement(1099045..1099440) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1099440 3795486 SDY_1185 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402831.1 1099045 R 300267 CDS YP_402832.1 82776483 3795487 1099853..1100155 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1100155 3795487 SDY_1186 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402832.1 1099853 D 300267 CDS YP_402833.1 82776484 3795488 1100296..1101009 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1101009 3795488 SDY_1187 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402833.1 1100296 D 300267 CDS YP_402834.1 82776485 3795490 complement(1101937..1102824) 1 NC_007606.1 no effect on switching; With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1102824 motA 3795490 motA Shigella dysenteriae Sd197 flagellar motor protein MotA YP_402834.1 1101937 R 300267 CDS YP_402835.1 82776486 3795491 complement(1102950..1103495) 1 NC_007606.1 transcription initiation factor; With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 1103495 flhC 3795491 flhC Shigella dysenteriae Sd197 transcriptional activator FlhC YP_402835.1 1102950 R 300267 CDS YP_402836.1 82776487 3795492 complement(1103498..1103857) 1 NC_007606.1 transcriptional initiation factor; with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 1103857 flhD 3795492 flhD Shigella dysenteriae Sd197 transcriptional activator FlhD YP_402836.1 1103498 R 300267 CDS YP_402837.1 82776488 3795493 1104628..1105056 1 NC_007606.1 ''ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress''; universal stress protein UspC 1105056 yecG 3795493 yecG Shigella dysenteriae Sd197 universal stress protein UspC YP_402837.1 1104628 D 300267 CDS YP_402838.1 82776489 3795494 complement(1105063..1106487) 1 NC_007606.1 Code: G; COG: COG0380; trehalose-6-phosphate synthase 1106487 otsA 3795494 otsA Shigella dysenteriae Sd197 trehalose-6-phosphate synthase YP_402838.1 1105063 R 300267 CDS YP_402839.1 82776490 3795496 complement(1107028..1107867) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 1107867 3795496 SDY_1195 Shigella dysenteriae Sd197 insertion sequence element IS911 integrase core domain-containing protein YP_402839.1 1107028 R 300267 CDS YP_402840.1 82776491 3795497 complement(1107894..1108220) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1108220 3795497 SDY_1196 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402840.1 1107894 R 300267 CDS YP_402841.1 82776492 3795498 complement(1108193..1108963) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1108963 3795498 SDY_1197 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_402841.1 1108193 R 300267 CDS YP_402842.1 82776493 3795596 complement(1109104..1109406) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1109406 3795596 SDY_1198 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402842.1 1109104 R 300267 CDS YP_402843.1 82776494 3795597 1109483..1109758 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1109758 insA 3795597 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402843.1 1109483 D 300267 CDS YP_402844.1 82776495 3795598 1109803..1110180 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1110180 insB 3795598 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402844.1 1109803 D 300267 CDS YP_009000691.1 578793154 18263004 1110728..1111000 1 NC_007606.1 insertion element iso-IS1N protein InsA 1111000 18263004 SDY_1200a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000691.1 1110728 D 300267 CDS YP_402845.1 82776496 3795599 1111027..1111422 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1111422 3795599 SDY_1201 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402845.1 1111027 D 300267 CDS YP_402846.1 82776497 3795600 1111815..1112834 1 NC_007606.1 hypothetical protein 1112834 3795600 SDY_1202 Shigella dysenteriae Sd197 hypothetical protein YP_402846.1 1111815 D 300267 CDS YP_402847.1 82776498 3795601 complement(1112809..1113204) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1113204 3795601 SDY_1203 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402847.1 1112809 R 300267 CDS YP_009000692.1 578793155 18263005 complement(1113231..1113503) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1113503 18263005 SDY_1203a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000692.1 1113231 R 300267 CDS YP_402848.1 82776499 3795602 1113426..1116020 1 NC_007606.1 Code: MU; COG: COG3468; ATPase 1116020 ypjA 3795602 ypjA Shigella dysenteriae Sd197 ATPase YP_402848.1 1113426 D 300267 CDS YP_402849.1 82776500 3795603 complement(1116391..1116657) 1 NC_007606.1 reverses MinC inhibition of ftsZ ring formation; works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1116657 minE 3795603 minE Shigella dysenteriae Sd197 cell division topological specificity factor MinE YP_402849.1 1116391 R 300267 CDS YP_402850.1 82776501 3795604 complement(1116661..1117473) 1 NC_007606.1 cell division inhibitor, a membrane ATPase, activates minC; ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1117473 minD 3795604 minD Shigella dysenteriae Sd197 cell division inhibitor MinD YP_402850.1 1116661 R 300267 CDS YP_402851.1 82776502 3795605 complement(1117497..1118192) 1 NC_007606.1 cell division inhibitor, inhibits ftsZ ring formation; blocks the formation of polar Z-ring septums; septum formation inhibitor 1118192 minC 3795605 minC Shigella dysenteriae Sd197 septum formation inhibitor YP_402851.1 1117497 R 300267 CDS YP_402852.1 82776503 3795606 complement(1118832..1119227) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1119227 3795606 SDY_1208 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402852.1 1118832 R 300267 CDS YP_009000693.1 578793156 18263006 complement(1119254..1119526) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1119526 18263006 SDY_1208a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000693.1 1119254 R 300267 CDS YP_402853.1 82776504 3795607 1119754..1120038 1 NC_007606.1 hypothetical protein 1120038 ycgJ 3795607 ycgJ Shigella dysenteriae Sd197 hypothetical protein YP_402853.1 1119754 D 300267 CDS YP_402854.1 82776505 3795608 complement(1120158..1120559) 1 NC_007606.1 hypothetical protein 1120559 ycgK 3795608 ycgK Shigella dysenteriae Sd197 hypothetical protein YP_402854.1 1120158 R 300267 CDS YP_402855.1 82776506 3795609 1120766..1121092 1 NC_007606.1 Code: S; COG: COG3100; hypothetical protein 1121092 ycgL 3795609 ycgL Shigella dysenteriae Sd197 hypothetical protein YP_402855.1 1120766 D 300267 CDS YP_402856.1 82776507 3795610 1121164..1121823 1 NC_007606.1 Code: Q; COG: COG0179; hypothetical protein 1121823 3795610 SDY_1212 Shigella dysenteriae Sd197 hypothetical protein YP_402856.1 1121164 D 300267 CDS YP_402857.2 161950128 3795611 1121915..1122361 1 NC_007606.1 Code: S; COG: COG2983; hypothetical protein 1122361 ycgN 3795611 ycgN Shigella dysenteriae Sd197 hypothetical protein YP_402857.2 1121915 D 300267 CDS YP_402858.1 82776509 3795612 1122444..1122719 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1122719 insA 3795612 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402858.1 1122444 D 300267 CDS YP_402859.1 82776510 3795613 1122764..1123141 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1123141 insB 3795613 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402859.1 1122764 D 300267 CDS YP_009000694.1 578793157 18263007 1123372..1123644 1 NC_007606.1 insertion element iso-IS1N protein InsA 1123644 18263007 SDY_1215a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000694.1 1123372 D 300267 CDS YP_402860.1 82776511 3795614 1123671..1124066 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1124066 3795614 SDY_1216 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402860.1 1123671 D 300267 CDS YP_009000695.1 578793158 18263008 1124223..1124495 1 NC_007606.1 insertion element iso-IS1N protein InsA 1124495 18263008 SDY_1216a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000695.1 1124223 D 300267 CDS YP_402862.1 82776513 3797183 1124522..1124917 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1124917 3797183 SDY_1218 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402862.1 1124522 D 300267 CDS YP_402863.1 82776514 3797185 1125536..1125955 1 NC_007606.1 SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC; binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1125955 umuD 3797185 umuD Shigella dysenteriae Sd197 DNA polymerase V subunit UmuD YP_402863.1 1125536 D 300267 CDS YP_402864.1 82776515 3797186 1125955..1127214 1 NC_007606.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1127214 umuC 3797186 umuC Shigella dysenteriae Sd197 DNA polymerase V subunit UmuC YP_402864.1 1125955 D 300267 CDS YP_402865.1 82776516 3797187 complement(1127260..1127790) 1 NC_007606.1 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella; disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1127790 dsbB 3797187 dsbB Shigella dysenteriae Sd197 disulfide bond formation protein B YP_402865.1 1127260 R 300267 CDS YP_402866.1 82776517 3797188 complement(1127936..1129477) 1 NC_007606.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1129477 nhaB 3797188 nhaB Shigella dysenteriae Sd197 sodium/proton antiporter YP_402866.1 1127936 R 300267 CDS YP_402867.1 82776518 3797189 1129699..1130418 1 NC_007606.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1130418 fadR 3797189 fadR Shigella dysenteriae Sd197 fatty acid metabolism regulator YP_402867.1 1129699 D 300267 CDS YP_402868.1 82776519 3797190 complement(1130470..1132002) 1 NC_007606.1 Code: S; COG: COG2719; SpoVR family protein 1132002 ycgB 3797190 ycgB Shigella dysenteriae Sd197 SpoVR family protein YP_402868.1 1130470 R 300267 CDS YP_402869.1 82776520 3797191 1132332..1133630 1 NC_007606.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1133630 dadA 3797191 dadA Shigella dysenteriae Sd197 D-amino acid dehydrogenase small subunit YP_402869.1 1132332 D 300267 CDS YP_402872.2 161950127 3797195 complement(1136962..1138698) 1 NC_007606.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1138698 3797195 SDY_1230 Shigella dysenteriae Sd197 potassium/proton antiporter YP_402872.2 1136962 R 300267 CDS YP_402873.1 82776525 3797197 complement(1138793..1139707) 1 NC_007606.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1139707 ldcA 3797197 ldcA Shigella dysenteriae Sd197 L,D-carboxypeptidase A YP_402873.1 1138793 R 300267 CDS YP_402874.1 82776524 3797196 1139693..1140418 1 NC_007606.1 Code: M; COG: COG0741; murein transglycosylase E 1140418 mltE 3797196 mltE Shigella dysenteriae Sd197 murein transglycosylase E YP_402874.1 1139693 D 300267 CDS YP_402875.1 82776526 3797198 complement(1140420..1141154) 1 NC_007606.1 Code: M; COG: COG5581; hypothetical protein 1141154 ycgR 3797198 ycgR Shigella dysenteriae Sd197 hypothetical protein YP_402875.1 1140420 R 300267 CDS YP_402876.1 82776527 3797199 1141355..1141609 1 NC_007606.1 Code: S; COG: COG2261; hypothetical protein 1141609 ymgE 3797199 ymgE Shigella dysenteriae Sd197 hypothetical protein YP_402876.1 1141355 D 300267 CDS YP_402877.1 82776528 3797200 complement(1141659..1143629) 1 NC_007606.1 probably tonB dependent; Code: P; COG: COG1629; outer membrane receptor 1143629 prrA 3797200 prrA Shigella dysenteriae Sd197 outer membrane receptor YP_402877.1 1141659 R 300267 CDS YP_402878.1 82776529 3797201 complement(1143655..1144509) 1 NC_007606.1 involved in molybdenum transport; molybdenum transport protein ModD 1144509 modD 3797201 modD Shigella dysenteriae Sd197 molybdenum transport protein ModD YP_402878.1 1143655 R 300267 CDS YP_009000696.1 578793159 18263009 1145010..1145282 1 NC_007606.1 insertion element iso-IS1N protein InsA 1145282 18263009 SDY_1238a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000696.1 1145010 D 300267 CDS YP_402880.1 82776531 3798350 1145309..1145704 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1145704 3798350 SDY_1238 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402880.1 1145309 D 300267 CDS YP_402881.1 82776532 3798351 complement(1145679..1146092) 1 NC_007606.1 Code: QR; COG: COG0500; hypothetical protein 1146092 3798351 SDY_1239 Shigella dysenteriae Sd197 hypothetical protein YP_402881.1 1145679 R 300267 CDS YP_402882.1 82776533 3798352 complement(1146102..1146860) 1 NC_007606.1 Code: PH; COG: COG1120; iron compound ABC transporter ATP-binding protein 1146860 3798352 SDY_1240 Shigella dysenteriae Sd197 iron compound ABC transporter ATP-binding protein YP_402882.1 1146102 R 300267 CDS YP_402883.1 82776534 3798353 complement(1146857..1147837) 1 NC_007606.1 Code: P; COG: COG0609; iron compound ABC transporter permease 1147837 3798353 SDY_1241 Shigella dysenteriae Sd197 iron compound ABC transporter permease YP_402883.1 1146857 R 300267 CDS YP_402886.1 82776537 3798356 complement(1149109..1149324) 1 NC_007606.1 insertion element iso-IS1n protein InsB 1149324 3798356 SDY_1244 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402886.1 1149109 R 300267 CDS YP_009000697.1 578793160 18263010 complement(1149533..1149805) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1149805 18263010 SDY_1244a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000697.1 1149533 R 300267 CDS YP_402887.1 82776539 3798358 complement(1149966..1151663) 1 NC_007606.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1151663 treA 3798358 treA Shigella dysenteriae Sd197 trehalase YP_402887.1 1149966 R 300267 CDS YP_402889.1 82776540 3798360 complement(1153413..1153748) 1 NC_007606.1 Code: G; COG: COG2376; dihydroxyacetone kinase 1153748 3798360 SDY_1248 Shigella dysenteriae Sd197 dihydroxyacetone kinase YP_402889.1 1153413 R 300267 CDS YP_402890.1 82776541 3798361 1153779..1154210 1 NC_007606.1 hypothetical protein 1154210 3798361 SDY_1249 Shigella dysenteriae Sd197 hypothetical protein YP_402890.1 1153779 D 300267 CDS YP_402891.1 82776542 3798363 complement(1157844..1158239) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1158239 3798363 SDY_1251 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402891.1 1157844 R 300267 CDS YP_009000698.1 578793161 18263011 complement(1158266..1158538) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1158538 18263011 SDY_1251a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000698.1 1158266 R 300267 CDS YP_402892.1 82776543 3798364 complement(1158812..1159903) 1 NC_007606.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1159903 ychF 3798364 ychF Shigella dysenteriae Sd197 GTP-dependent nucleic acid-binding protein EngD YP_402892.1 1158812 R 300267 CDS YP_402893.1 82776544 3798365 complement(1160020..1160604) 1 NC_007606.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1160604 pth 3798365 pth Shigella dysenteriae Sd197 peptidyl-tRNA hydrolase YP_402893.1 1160020 R 300267 CDS YP_402894.1 82776545 3798366 1160882..1161160 1 NC_007606.1 ''YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function''; hypothetical protein 1161160 ychH 3798366 ychH Shigella dysenteriae Sd197 hypothetical protein YP_402894.1 1160882 D 300267 CDS YP_402895.1 82776546 3798367 complement(1161215..1162867) 1 NC_007606.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 1162867 ychM 3798367 ychM Shigella dysenteriae Sd197 sulfate transporter YchM YP_402895.1 1161215 R 300267 CDS YP_402896.1 82776547 3798368 complement(1163019..1163966) 1 NC_007606.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1163966 prsA 3798368 prsA Shigella dysenteriae Sd197 ribose-phosphate pyrophosphokinase YP_402896.1 1163019 R 300267 CDS YP_402897.1 82776548 3798783 complement(1164117..1164968) 1 NC_007606.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1164968 ipk 3798783 ipk Shigella dysenteriae Sd197 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_402897.1 1164117 R 300267 CDS YP_402898.1 82776549 3798784 complement(1164968..1165591) 1 NC_007606.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB 1165591 lolB 3798784 lolB Shigella dysenteriae Sd197 molecular chaperone LolB YP_402898.1 1164968 R 300267 CDS YP_402899.1 82776550 3798785 1165805..1167061 1 NC_007606.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1167061 hemA 3798785 hemA Shigella dysenteriae Sd197 glutamyl-tRNA reductase YP_402899.1 1165805 D 300267 CDS YP_402900.1 82776551 3798786 1167103..1168185 1 NC_007606.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1168185 prfA 3798786 prfA Shigella dysenteriae Sd197 peptide chain release factor 1 YP_402900.1 1167103 D 300267 CDS YP_402901.1 82776552 3798787 1168185..1169018 1 NC_007606.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1169018 hemK 3798787 hemK Shigella dysenteriae Sd197 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_402901.1 1168185 D 300267 CDS YP_402902.1 82776553 3798788 1169015..1169407 1 NC_007606.1 Code: S; COG: COG3094; transcriptional regulator 1169407 3798788 SDY_1262 Shigella dysenteriae Sd197 transcriptional regulator YP_402902.1 1169015 D 300267 CDS YP_402903.1 82776554 3798789 1169411..1170220 1 NC_007606.1 Code: S; COG: COG2912; transcriptional regulator 1170220 ychA 3798789 ychA Shigella dysenteriae Sd197 transcriptional regulator YP_402903.1 1169411 D 300267 CDS YP_402904.1 82776555 3798790 1170256..1171110 1 NC_007606.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1171110 kdsA 3798790 kdsA Shigella dysenteriae Sd197 2-dehydro-3-deoxyphosphooctonate aldolase YP_402904.1 1170256 D 300267 CDS YP_402905.1 82776556 3798791 complement(1171258..1171392) 1 NC_007606.1 hypothetical protein 1171392 3798791 SDY_1265 Shigella dysenteriae Sd197 hypothetical protein YP_402905.1 1171258 R 300267 CDS YP_402906.1 82776557 3798792 complement(1171770..1172870) 1 NC_007606.1 Code: P; COG: COG0387; calcium/sodium:proton antiporter 1172870 chaA 3798792 chaA Shigella dysenteriae Sd197 calcium/sodium:proton antiporter YP_402906.1 1171770 R 300267 CDS YP_402907.1 82776558 3798793 1173140..1173415 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1173415 insA 3798793 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402907.1 1173140 D 300267 CDS YP_402909.1 82776560 3798795 1173917..1174147 1 NC_007606.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1174147 chaB 3798795 chaB Shigella dysenteriae Sd197 cation transport regulator YP_402909.1 1173917 D 300267 CDS YP_402910.1 82776561 3798796 1174284..1174940 1 NC_007606.1 Code: P; COG: COG3703; cation transport regulator 1174940 chaC 3798796 chaC Shigella dysenteriae Sd197 cation transport regulator YP_402910.1 1174284 D 300267 CDS YP_402911.1 82776562 3798797 complement(1175044..1175397) 1 NC_007606.1 Code: P; COG: COG1553; hypothetical protein 1175397 ychN 3798797 ychN Shigella dysenteriae Sd197 hypothetical protein YP_402911.1 1175044 R 300267 CDS YP_009000699.1 578793162 18263012 1175829..1176101 1 NC_007606.1 insertion element iso-IS1N protein InsA 1176101 18263012 SDY_1273a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000699.1 1175829 D 300267 CDS YP_402913.1 82776564 3798799 1176128..1176523 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1176523 3798799 SDY_1273 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402913.1 1176128 D 300267 CDS YP_402914.1 82776565 3798801 complement(1177738..1178388) 1 NC_007606.1 pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1178388 narL 3798801 narL Shigella dysenteriae Sd197 transcriptional regulator NarL YP_402914.1 1177738 R 300267 CDS YP_402915.1 82776566 3796785 complement(1178381..1180177) 1 NC_007606.1 histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850; nitrate/nitrite sensor protein NarX 1180177 narX 3796785 narX Shigella dysenteriae Sd197 nitrate/nitrite sensor protein NarX YP_402915.1 1178381 R 300267 CDS YP_402917.1 82776568 3796787 1180516..1181907 1 NC_007606.1 Code: P; COG: COG2223; nitrite extrusion protein 1181907 narK 3796787 narK Shigella dysenteriae Sd197 nitrite extrusion protein YP_402917.1 1180516 D 300267 CDS YP_402918.1 82776569 3796788 1182300..1186043 1 NC_007606.1 Code: C; COG: COG5013; nitrate reductase 1 subunit alpha 1186043 narG 3796788 narG Shigella dysenteriae Sd197 nitrate reductase 1 subunit alpha YP_402918.1 1182300 D 300267 CDS YP_402919.1 82776570 3796789 1186040..1187578 1 NC_007606.1 Code: C; COG: COG1140; nitrate reductase 1 subunit beta 1187578 narH 3796789 narH Shigella dysenteriae Sd197 nitrate reductase 1 subunit beta YP_402919.1 1186040 D 300267 CDS YP_402920.1 82776571 3796790 1187575..1188285 1 NC_007606.1 Code: C; COG: COG2180; nitrate reductase 1 subunit delta 1188285 narJ 3796790 narJ Shigella dysenteriae Sd197 nitrate reductase 1 subunit delta YP_402920.1 1187575 D 300267 CDS YP_402921.1 82776572 3796791 1188285..1188962 1 NC_007606.1 Code: C; COG: COG2181; nitrate reductase 1 cytochrome b(NR) subunit gamma 1188962 narI 3796791 narI Shigella dysenteriae Sd197 nitrate reductase 1 cytochrome b(NR) subunit gamma YP_402921.1 1188285 D 300267 CDS YP_402922.1 82776573 3796793 complement(1189567..1190409) 1 NC_007606.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1190409 purU 3796793 purU Shigella dysenteriae Sd197 formyltetrahydrofolate deformylase YP_402922.1 1189567 R 300267 CDS YP_402923.1 82776574 3796794 complement(1190459..1190917) 1 NC_007606.1 Code: S; COG: COG3012; hypothetical protein 1190917 ychJ 3796794 ychJ Shigella dysenteriae Sd197 hypothetical protein YP_402923.1 1190459 R 300267 CDS YP_402925.1 82776576 3796796 1192028..1193041 1 NC_007606.1 Code: T; COG: COG0784; response regulator of RpoS 1193041 hnr 3796796 hnr Shigella dysenteriae Sd197 response regulator of RpoS YP_402925.1 1192028 D 300267 CDS YP_402926.1 82776577 3796797 1193243..1194151 1 NC_007606.1 ''together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose''; UTP-glucose-1-phosphate uridylyltransferase 1194151 galU 3796797 galU Shigella dysenteriae Sd197 UTP-glucose-1-phosphate uridylyltransferase YP_402926.1 1193243 D 300267 CDS YP_402927.1 82776578 3796798 complement(1194295..1194708) 1 NC_007606.1 HU, BH2, HD, NS; pleiotropic regulator; Code: R; COG: COG2916; global DNA-binding transcriptional dual regulator H-NS 1194708 hns 3796798 hns Shigella dysenteriae Sd197 global DNA-binding transcriptional dual regulator H-NS YP_402927.1 1194295 R 300267 CDS YP_402928.1 82776579 3796799 1195312..1195929 1 NC_007606.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1195929 tdk 3796799 tdk Shigella dysenteriae Sd197 thymidine kinase YP_402928.1 1195312 D 300267 CDS YP_402929.1 82776580 3796800 complement(1195955..1196350) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1196350 3796800 SDY_1291 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402929.1 1195955 R 300267 CDS YP_402930.1 82776581 3796801 1197041..1198174 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 1198174 3796801 SDY_1292 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_402930.1 1197041 D 300267 CDS YP_402931.1 82776582 3796802 1198225..1198500 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1198500 insA 3796802 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402931.1 1198225 D 300267 CDS YP_402933.1 82776584 3796690 complement(1199206..1201881) 1 NC_007606.1 Code: C; COG: COG1454; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1201881 adhE 3796690 adhE Shigella dysenteriae Sd197 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_402933.1 1199206 R 300267 CDS YP_009000700.1 578793163 18263014 1202289..1202561 1 NC_007606.1 insertion element iso-IS1N protein InsA 1202561 18263014 SDY_1294a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000700.1 1202289 D 300267 CDS YP_402934.1 82776585 3796691 1202588..1202983 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1202983 3796691 SDY_1296 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_402934.1 1202588 D 300267 CDS YP_402935.1 82776586 3796692 1203112..1203387 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1203387 insA 3796692 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402935.1 1203112 D 300267 CDS YP_402936.1 82776587 3796693 1203432..1203809 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1203809 insB 3796693 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402936.1 1203432 D 300267 CDS YP_402937.1 82776588 3796694 complement(1204066..1204461) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1204461 3796694 SDY_1299 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_402937.1 1204066 R 300267 CDS YP_009000701.1 578793164 18263015 complement(1204488..1204760) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1204760 18263015 SDY_1301a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000701.1 1204488 R 300267 CDS YP_402939.1 82776590 3796696 1205560..1207191 1 NC_007606.1 oligopeptide transport; periplasmic binding protein; Code: E; COG: COG4166; hypothetical protein 1207191 oppA 3796696 oppA Shigella dysenteriae Sd197 hypothetical protein YP_402939.1 1205560 D 300267 CDS YP_402940.1 82776591 3796697 1207277..1208197 1 NC_007606.1 Code: EP; COG: COG0601; oligopeptide transporter permease 1208197 oppB 3796697 oppB Shigella dysenteriae Sd197 oligopeptide transporter permease YP_402940.1 1207277 D 300267 CDS YP_402941.1 82776592 3796698 1208212..1209120 1 NC_007606.1 Code: EP; COG: COG1173; hypothetical protein 1209120 oppC 3796698 oppC Shigella dysenteriae Sd197 hypothetical protein YP_402941.1 1208212 D 300267 CDS YP_402942.1 82776593 3796699 1209132..1210145 1 NC_007606.1 Code: EP; COG: COG0444; oligopeptide ABC transporter ATP-binding protein 1210145 oppD 3796699 oppD Shigella dysenteriae Sd197 oligopeptide ABC transporter ATP-binding protein YP_402942.1 1209132 D 300267 CDS YP_402943.1 82776594 3796700 1210142..1211146 1 NC_007606.1 Code: E; COG: COG4608; hypothetical protein 1211146 oppF 3796700 oppF Shigella dysenteriae Sd197 hypothetical protein YP_402943.1 1210142 D 300267 CDS YP_402944.2 161950126 3796701 complement(1211199..1211528) 1 NC_007606.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1211528 3796701 SDY_1306 Shigella dysenteriae Sd197 dsDNA-mimic protein YP_402944.2 1211199 R 300267 CDS YP_402945.1 82776596 3796702 complement(1211563..1213023) 1 NC_007606.1 a major membrane phospholipid; novobiocin sensitivity; catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1213023 cls 3796702 cls Shigella dysenteriae Sd197 cardiolipin synthetase YP_402945.1 1211563 R 300267 CDS YP_402946.1 82776597 3796703 complement(1213393..1214646) 1 NC_007606.1 Code: P; COG: COG1226; voltage-gated potassium channel 1214646 kch 3796703 kch Shigella dysenteriae Sd197 voltage-gated potassium channel YP_402946.1 1213393 R 300267 CDS YP_402947.2 161950125 3796704 complement(1214946..1215242) 1 NC_007606.1 ''unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity''; hypothetical protein 1215242 yciI 3796704 yciI Shigella dysenteriae Sd197 hypothetical protein YP_402947.2 1214946 R 300267 CDS YP_402948.1 82776599 3796705 1216727..1217092 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1217092 3796705 SDY_1310 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_402948.1 1216727 D 300267 CDS YP_402949.2 161950124 3796706 1217050..1217928 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1217928 3796706 SDY_1311 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_402949.2 1217050 D 300267 CDS YP_402950.1 82776601 3796707 1218133..1218684 1 NC_007606.1 Code: L; COG: COG1961; DNA invertase-like protein 1218684 3796707 SDY_1312 Shigella dysenteriae Sd197 DNA invertase-like protein YP_402950.1 1218133 D 300267 CDS YP_402951.1 82776602 3796708 1218765..1219067 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1219067 3796708 SDY_1313 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_402951.1 1218765 D 300267 CDS YP_402954.1 82776605 3798748 1220191..1220910 1 NC_007606.1 energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins; ''membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins''; transporter 1220910 tonB 3798748 tonB Shigella dysenteriae Sd197 transporter YP_402954.1 1220191 D 300267 CDS YP_402955.1 82776606 3798749 complement(1220950..1221348) 1 NC_007606.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase 1221348 yciA 3798749 yciA Shigella dysenteriae Sd197 acyl-CoA thioester hydrolase YP_402955.1 1220950 R 300267 CDS YP_402956.1 82776607 3798750 complement(1221453..1221992) 1 NC_007606.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1221992 yciB 3798750 yciB Shigella dysenteriae Sd197 intracellular septation protein A YP_402956.1 1221453 R 300267 CDS YP_402957.1 82776608 3798751 complement(1222022..1222765) 1 NC_007606.1 hypothetical protein 1222765 yciC 3798751 yciC Shigella dysenteriae Sd197 hypothetical protein YP_402957.1 1222022 R 300267 CDS YP_402958.1 82776609 3798752 1223122..1223760 1 NC_007606.1 receptor for colicin S4; outer membrane protein W 1223760 yciD 3798752 yciD Shigella dysenteriae Sd197 outer membrane protein W YP_402958.1 1223122 D 300267 CDS YP_402959.1 82776610 3798753 complement(1223820..1224329) 1 NC_007606.1 Code: S; COG: COG3685; hypothetical protein 1224329 yciE 3798753 yciE Shigella dysenteriae Sd197 hypothetical protein YP_402959.1 1223820 R 300267 CDS YP_402961.1 82776612 3798755 1224614..1224889 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1224889 insA 3798755 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402961.1 1224614 D 300267 CDS YP_402962.1 82776613 3798756 1224934..1225311 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1225311 insB 3798756 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402962.1 1224934 D 300267 CDS YP_009000702.1 578793165 18263016 1225496..1225768 1 NC_007606.1 insertion element iso-IS1N protein InsA 1225768 18263016 SDY_1324a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000702.1 1225496 D 300267 CDS YP_402964.1 82776615 3798758 1226204..1226506 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1226506 3798758 SDY_1326 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402964.1 1226204 D 300267 CDS YP_402966.1 82776617 3798760 complement(1227673..1228479) 1 NC_007606.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1228479 trpA 3798760 trpA Shigella dysenteriae Sd197 tryptophan synthase subunit alpha YP_402966.1 1227673 R 300267 CDS YP_402967.1 82776618 3798761 complement(1228479..1229672) 1 NC_007606.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1229672 trpB 3798761 trpB Shigella dysenteriae Sd197 tryptophan synthase subunit beta YP_402967.1 1228479 R 300267 CDS YP_402968.1 82776619 3798762 complement(1229684..1231045) 1 NC_007606.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1231045 trpC 3798762 trpC Shigella dysenteriae Sd197 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_402968.1 1229684 R 300267 CDS YP_402969.1 82776620 3798763 complement(1231046..1232641) 1 NC_007606.1 glutamine amidotransferase and phosphoribosylanthranilate transferase; bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1232641 trpD 3798763 trpD Shigella dysenteriae Sd197 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_402969.1 1231046 R 300267 CDS YP_402970.1 82776621 3798764 complement(1232641..1234203) 1 NC_007606.1 ''with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine''; anthranilate synthase component I 1234203 trpE 3798764 trpE Shigella dysenteriae Sd197 anthranilate synthase component I YP_402970.1 1232641 R 300267 CDS YP_402972.1 82776623 3797553 1234477..1235358 1 NC_007606.1 Code: R; COG: COG0613; metal-dependent phosphoesterase 1235358 yciV 3797553 yciV Shigella dysenteriae Sd197 metal-dependent phosphoesterase YP_402972.1 1234477 D 300267 CDS YP_402973.1 82776624 3797554 1235319..1235975 1 NC_007606.1 Code: J; COG: COG0009; hypothetical protein 1235975 yciO 3797554 yciO Shigella dysenteriae Sd197 hypothetical protein YP_402973.1 1235319 D 300267 CDS YP_402974.1 82776625 3797555 1236040..1236315 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1236315 insA 3797555 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402974.1 1236040 D 300267 CDS YP_402975.1 82776626 3797556 1236360..1236737 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1236737 insB 3797556 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402975.1 1236360 D 300267 CDS YP_402976.1 82776627 3797557 1236766..1237191 1 NC_007606.1 hypothetical protein 1237191 3797557 SDY_1338 Shigella dysenteriae Sd197 hypothetical protein YP_402976.1 1236766 D 300267 CDS YP_402977.1 82776628 3797558 1237404..1238276 1 NC_007606.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1238276 yciL 3797558 yciL Shigella dysenteriae Sd197 23S rRNA pseudouridylate synthase B YP_402977.1 1237404 D 300267 CDS YP_402978.1 82776629 3797559 complement(1238316..1238906) 1 NC_007606.1 ''catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide''; cob(I)yrinic acid a,c-diamide adenosyltransferase 1238906 btuR 3797559 btuR Shigella dysenteriae Sd197 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_402978.1 1238316 R 300267 CDS YP_402979.1 82776630 3797560 complement(1238903..1239661) 1 NC_007606.1 Code: IQR; COG: COG1028; short chain dehydrogenase 1239661 yciK 3797560 yciK Shigella dysenteriae Sd197 short chain dehydrogenase YP_402979.1 1238903 R 300267 CDS YP_402980.1 82776631 3797561 1239881..1240921 1 NC_007606.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1240921 sohB 3797561 sohB Shigella dysenteriae Sd197 periplasmic protease YP_402980.1 1239881 D 300267 CDS YP_402981.1 82776632 3797562 complement(1240957..1241208) 1 NC_007606.1 hypothetical protein 1241208 yciN 3797562 yciN Shigella dysenteriae Sd197 hypothetical protein YP_402981.1 1240957 R 300267 CDS YP_402982.1 82776633 3797563 1241588..1244185 1 NC_007606.1 ''catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity''; DNA topoisomerase I 1244185 topA 3797563 topA Shigella dysenteriae Sd197 DNA topoisomerase I YP_402982.1 1241588 D 300267 CDS YP_402983.1 82776634 3797564 1244395..1245369 1 NC_007606.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1245369 cysB 3797564 cysB Shigella dysenteriae Sd197 transcriptional regulator CysB YP_402983.1 1244395 D 300267 CDS YP_402984.1 82776635 3797565 complement(1245629..1246006) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1246006 insB 3797565 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402984.1 1245629 R 300267 CDS YP_402985.1 82776636 3797566 complement(1246051..1246326) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1246326 insA 3797566 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402985.1 1246051 R 300267 CDS YP_402986.1 82776637 3797567 1246440..1246604 1 NC_007606.1 hypothetical protein 1246604 3797567 SDY_1348 Shigella dysenteriae Sd197 hypothetical protein YP_402986.1 1246440 D 300267 CDS YP_402987.1 82776638 3797568 1246586..1246774 1 NC_007606.1 hypothetical protein 1246774 yciX 3797568 yciX Shigella dysenteriae Sd197 hypothetical protein YP_402987.1 1246586 D 300267 CDS YP_402989.1 82776640 3797571 complement(1250093..1250395) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1250395 3797571 SDY_1352 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_402989.1 1250093 R 300267 CDS YP_402990.1 82776641 3797046 complement(1251155..1251745) 1 NC_007606.1 ''catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate''; GTP cyclohydrolase II 1251745 ribA 3797046 ribA Shigella dysenteriae Sd197 GTP cyclohydrolase II YP_402990.1 1251155 R 300267 CDS YP_402991.1 82776642 3797047 1251915..1252679 1 NC_007606.1 Code: I; COG: COG0671; phosphatidylglycerophosphatase B 1252679 pgpB 3797047 pgpB Shigella dysenteriae Sd197 phosphatidylglycerophosphatase B YP_402991.1 1251915 D 300267 CDS YP_402992.1 82776643 3797048 1252828..1253136 1 NC_007606.1 Code: S; COG: COG3771; hypothetical protein 1253136 yciS 3797048 yciS Shigella dysenteriae Sd197 hypothetical protein YP_402992.1 1252828 D 300267 CDS YP_402993.1 82776644 3797049 1253143..1254312 1 NC_007606.1 Code: G; COG: COG2956; hypothetical protein 1254312 yciM 3797049 yciM Shigella dysenteriae Sd197 hypothetical protein YP_402993.1 1253143 D 300267 CDS YP_402994.1 82776645 3797050 1254505..1255242 1 NC_007606.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1255242 pyrF 3797050 pyrF Shigella dysenteriae Sd197 orotidine 5'-phosphate decarboxylase YP_402994.1 1254505 D 300267 CDS YP_402995.1 82776646 3797051 1255239..1255568 1 NC_007606.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1255568 yciH 3797051 yciH Shigella dysenteriae Sd197 translation initiation factor Sui1 YP_402995.1 1255239 D 300267 CDS YP_402996.1 82776647 3797052 complement(1255866..1256243) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1256243 insB 3797052 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_402996.1 1255866 R 300267 CDS YP_402997.1 82776648 3797053 complement(1256288..1256563) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1256563 insA 3797053 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_402997.1 1256288 R 300267 CDS YP_402998.1 82776649 3797054 complement(1256729..1257478) 1 NC_007606.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 1257478 3797054 SDY_1361 Shigella dysenteriae Sd197 DeoR-type transcriptional regulator YP_402998.1 1256729 R 300267 CDS YP_402999.1 82776650 3797055 complement(1257568..1257741) 1 NC_007606.1 hypothetical protein 1257741 3797055 SDY_1362 Shigella dysenteriae Sd197 hypothetical protein YP_402999.1 1257568 R 300267 CDS YP_403000.1 82776651 3797057 1259930..1260205 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1260205 insA 3797057 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403000.1 1259930 D 300267 CDS YP_403001.1 82776652 3797058 1260250..1260627 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1260627 insB 3797058 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403001.1 1260250 D 300267 CDS YP_403002.1 82776653 3797059 complement(1260887..1262821) 1 NC_007606.1 mRNA degradation; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1262821 rnb 3797059 rnb Shigella dysenteriae Sd197 exoribonuclease II YP_403002.1 1260887 R 300267 CDS YP_403004.1 82776655 3797061 complement(1264141..1264929) 1 NC_007606.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1264929 fabI 3797061 fabI Shigella dysenteriae Sd197 enoyl-ACP reductase YP_403004.1 1264141 R 300267 CDS YP_403005.1 82776656 3797062 complement(1265366..1265761) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1265761 3797062 SDY_1369 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403005.1 1265366 R 300267 CDS YP_403006.1 82776657 3797063 1265956..1266249 1 NC_007606.1 hypothetical protein 1266249 3797063 SDY_1370 Shigella dysenteriae Sd197 hypothetical protein YP_403006.1 1265956 D 300267 CDS YP_403007.1 82776658 3797064 complement(1266246..1266641) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1266641 3797064 SDY_1371 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403007.1 1266246 R 300267 CDS YP_009000703.1 578793166 18263017 complement(1266668..1266940) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1266940 18263017 SDY_1370a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000703.1 1266668 R 300267 CDS YP_403008.1 82776659 3797065 1267290..1270391 1 NC_007606.1 Code: V; COG: COG0841; multidrug-efflux transport protein 1270391 3797065 SDY_1372 Shigella dysenteriae Sd197 multidrug-efflux transport protein YP_403008.1 1267290 D 300267 CDS YP_403011.1 82776662 3796541 1271783..1272934 1 NC_007606.1 Code: GEPR; COG: COG0477; membrane transport protein 1272934 3796541 SDY_1375 Shigella dysenteriae Sd197 membrane transport protein YP_403011.1 1271783 D 300267 CDS YP_403012.1 82776663 3796542 complement(1272983..1274179) 1 NC_007606.1 Code: L; COG: COG3547; insertion element IS110 transposase 1274179 3796542 SDY_1376 Shigella dysenteriae Sd197 insertion element IS110 transposase YP_403012.1 1272983 R 300267 CDS YP_403013.1 82776664 3796543 complement(1274438..1275244) 1 NC_007606.1 Code: V; COG: COG4167; peptide ABC transporter ATP-binding protein 1275244 sapF 3796543 sapF Shigella dysenteriae Sd197 peptide ABC transporter ATP-binding protein YP_403013.1 1274438 R 300267 CDS YP_403014.1 82776665 3796544 complement(1275246..1276238) 1 NC_007606.1 Code: V; COG: COG4170; peptide ABC transporter ATP-binding protein 1276238 sapD 3796544 sapD Shigella dysenteriae Sd197 peptide ABC transporter ATP-binding protein YP_403014.1 1275246 R 300267 CDS YP_403015.1 82776666 3796545 complement(1276238..1277128) 1 NC_007606.1 Code: V; COG: COG4171; SapC protein 1277128 sapC 3796545 sapC Shigella dysenteriae Sd197 SapC protein YP_403015.1 1276238 R 300267 CDS YP_403016.1 82776667 3796546 1277263..1278492 1 NC_007606.1 Code: L; COG: COG0582; integrase 1278492 int 3796546 int Shigella dysenteriae Sd197 integrase YP_403016.1 1277263 D 300267 CDS YP_403017.1 82776668 3796547 1278706..1278981 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1278981 insA 3796547 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403017.1 1278706 D 300267 CDS YP_403018.1 82776669 3796548 complement(1279827..1280507) 1 NC_007606.1 exonuclease 1280507 3796548 SDY_1382 Shigella dysenteriae Sd197 exonuclease YP_403018.1 1279827 R 300267 CDS YP_403019.1 82776670 3796549 complement(1280504..1281289) 1 NC_007606.1 recombination protein Bet 1281289 bet 3796549 bet Shigella dysenteriae Sd197 recombination protein Bet YP_403019.1 1280504 R 300267 CDS YP_403020.1 82776671 3796550 complement(1281295..1281591) 1 NC_007606.1 host-nuclease inhibitor protein Gam 1281591 gam 3796550 gam Shigella dysenteriae Sd197 host-nuclease inhibitor protein Gam YP_403020.1 1281295 R 300267 CDS YP_403021.1 82776672 3796551 complement(1281588..1282082) 1 NC_007606.1 hypothetical protein 1282082 3796551 SDY_1385 Shigella dysenteriae Sd197 hypothetical protein YP_403021.1 1281588 R 300267 CDS YP_403022.1 82776673 3796552 1282475..1282777 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1282777 3796552 SDY_1386 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403022.1 1282475 D 300267 CDS YP_403025.1 82776676 3796555 1283865..1284812 1 NC_007606.1 Shiga toxin subunit A 1284812 stxA 3796555 stxA Shigella dysenteriae Sd197 Shiga toxin subunit A YP_403025.1 1283865 D 300267 CDS YP_403026.1 82776677 3796556 1284822..1285091 1 NC_007606.1 Shiga toxin subunit B 1285091 stxB 3796556 stxB Shigella dysenteriae Sd197 Shiga toxin subunit B YP_403026.1 1284822 D 300267 CDS YP_403027.1 82776678 3796557 1285601..1287511 1 NC_007606.1 Code: L; COG: COG2801; hypothetical protein 1287511 yjhS 3796557 yjhS Shigella dysenteriae Sd197 hypothetical protein YP_403027.1 1285601 D 300267 CDS YP_403028.1 82776679 3799150 1287698..1288105 1 NC_007606.1 hypothetical protein 1288105 3799150 SDY_1392 Shigella dysenteriae Sd197 hypothetical protein YP_403028.1 1287698 D 300267 CDS YP_403029.1 82776680 3799151 1288182..1288397 1 NC_007606.1 lysis protein S 1288397 3799151 SDY_1393 Shigella dysenteriae Sd197 lysis protein S YP_403029.1 1288182 D 300267 CDS YP_403030.1 82776681 3799152 1288402..1288935 1 NC_007606.1 Code: R; COG: COG3772; endolysin 1288935 3799152 SDY_1394 Shigella dysenteriae Sd197 endolysin YP_403030.1 1288402 D 300267 CDS YP_403031.1 82776682 3799153 complement(1289159..1289998) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 1289998 3799153 SDY_1395 Shigella dysenteriae Sd197 insertion sequence element IS911 integrase core domain-containing protein YP_403031.1 1289159 R 300267 CDS YP_403032.1 82776683 3799154 1290194..1290469 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1290469 insA 3799154 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403032.1 1290194 D 300267 CDS YP_403033.1 82776684 3799155 1290514..1290891 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1290891 insB 3799155 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403033.1 1290514 D 300267 CDS YP_403034.1 82776685 3799157 1291370..1292767 1 NC_007606.1 Code: R; COG: COG3106; hypothetical protein 1292767 ycjX 3799157 ycjX Shigella dysenteriae Sd197 hypothetical protein YP_403034.1 1291370 D 300267 CDS YP_403035.1 82776686 3799158 1292764..1293798 1 NC_007606.1 Code: S; COG: COG3768; hypothetical protein 1293798 ycjF 3799158 ycjF Shigella dysenteriae Sd197 hypothetical protein YP_403035.1 1292764 D 300267 CDS YP_403036.1 82776687 3799159 1293973..1295514 1 NC_007606.1 transcriptional regulation of aroF, aroG, tyrA and aromatic amino acid transport; regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1295514 tyrR 3799159 tyrR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator TyrR YP_403036.1 1293973 D 300267 CDS YP_403037.1 82776688 3799160 complement(1295558..1296064) 1 NC_007606.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1296064 tpx 3799160 tpx Shigella dysenteriae Sd197 thiol peroxidase YP_403037.1 1295558 R 300267 CDS YP_403038.1 82776689 3799161 1296141..1297148 1 NC_007606.1 Code: MR; COG: COG4948; muconate cycloisomerase I 1297148 ycjG 3799161 ycjG Shigella dysenteriae Sd197 muconate cycloisomerase I YP_403038.1 1296141 D 300267 CDS YP_403039.1 82776690 3799162 complement(1297123..1297911) 1 NC_007606.1 Code: E; COG: COG2866; murein peptide amidase A 1297911 ycjI 3799162 ycjI Shigella dysenteriae Sd197 murein peptide amidase A YP_403039.1 1297123 R 300267 CDS YP_403040.1 82776691 3799163 complement(1298299..1298694) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1298694 3799163 SDY_1405 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403040.1 1298299 R 300267 CDS YP_009000704.1 578793167 18263018 complement(1298721..1298993) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1298993 18263018 SDY_1407a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000704.1 1298721 R 300267 CDS YP_009000705.1 578793168 18263019 1299405..1299677 1 NC_007606.1 insertion element iso-IS1N protein InsA 1299677 18263019 SDY_1408a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000705.1 1299405 D 300267 CDS YP_403042.1 82776693 3799165 1299704..1300099 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1300099 3799165 SDY_1407 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403042.1 1299704 D 300267 CDS YP_403043.1 82776694 3799166 1300229..1301128 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1301128 ycjZ 3799166 ycjZ Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_403043.1 1300229 D 300267 CDS YP_403044.1 82776695 3799167 1301444..1303078 1 NC_007606.1 Code: E; COG: COG4166; transport periplasmic protein 1303078 3799167 SDY_1409 Shigella dysenteriae Sd197 transport periplasmic protein YP_403044.1 1301444 D 300267 CDS YP_403045.1 82776696 3799168 complement(1303129..1304160) 1 NC_007606.1 Code: M; COG: COG0668; hypothetical protein 1304160 3799168 SDY_1410 Shigella dysenteriae Sd197 hypothetical protein YP_403045.1 1303129 R 300267 CDS YP_403046.1 82776697 3799169 complement(1304541..1304918) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1304918 insB 3799169 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403046.1 1304541 R 300267 CDS YP_403047.1 82776698 3797918 complement(1304963..1305238) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1305238 insA 3797918 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403047.1 1304963 R 300267 CDS YP_403048.1 82776699 3797919 complement(1305488..1306438) 1 NC_007606.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1306438 ydaA 3797919 ydaA Shigella dysenteriae Sd197 universal stress protein UspE YP_403048.1 1305488 R 300267 CDS YP_403049.1 82776700 3797920 complement(1306532..1306927) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1306927 3797920 SDY_1414 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403049.1 1306532 R 300267 CDS YP_009000706.1 578793169 18263020 complement(1306954..1307226) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1307226 18263020 SDY_1414a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000706.1 1306954 R 300267 CDS YP_403050.1 82776701 3797921 complement(1307364..1308116) 1 NC_007606.1 transcriptional regulation of aerobic, anaerobic respiration, osmotic balance; Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1308116 fnr 3797921 fnr Shigella dysenteriae Sd197 fumarate/nitrate reduction transcriptional regulator YP_403050.1 1307364 R 300267 CDS YP_403051.1 82776702 3797922 complement(1308311..1308826) 1 NC_007606.1 Code: L; COG: COG0350; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1308826 ogt 3797922 ogt Shigella dysenteriae Sd197 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_403051.1 1308311 R 300267 CDS YP_009000707.1 578793170 18263021 1309446..1309718 1 NC_007606.1 insertion element iso-IS1N protein InsA 1309718 18263021 SDY_1416a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000707.1 1309446 D 300267 CDS YP_403053.1 82776704 3797924 1309745..1310140 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1310140 3797924 SDY_1418 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403053.1 1309745 D 300267 CDS YP_403054.1 82776705 3797925 1310832..1311395 1 NC_007606.1 Code: S; COG: COG2840; hypothetical protein 1311395 ydaL 3797925 ydaL Shigella dysenteriae Sd197 hypothetical protein YP_403054.1 1310832 D 300267 CDS YP_403055.1 82776706 3797926 complement(1311416..1311715) 1 NC_007606.1 Code: T; COG: COG2199; hypothetical protein 1311715 3797926 SDY_1420 Shigella dysenteriae Sd197 hypothetical protein YP_403055.1 1311416 R 300267 CDS YP_403056.1 82776707 3797927 1311754..1312056 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1312056 3797927 SDY_1421 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403056.1 1311754 D 300267 CDS YP_403057.1 82776708 3797928 1312197..1313003 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1313003 3797928 SDY_1422 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_403057.1 1312197 D 300267 CDS YP_403058.1 82776709 3797929 complement(1312936..1313916) 1 NC_007606.1 Code: T; COG: COG2202; hypothetical protein 1313916 3797929 SDY_1423 Shigella dysenteriae Sd197 hypothetical protein YP_403058.1 1312936 R 300267 CDS YP_403059.1 82776710 3797930 1314171..1315154 1 NC_007606.1 Code: P; COG: COG0598; zinc transporter 1315154 zntB 3797930 zntB Shigella dysenteriae Sd197 zinc transporter YP_403059.1 1314171 D 300267 CDS YP_403060.1 82776711 3797932 complement(1316535..1317470) 1 NC_007606.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1317470 ydaO 3797932 ydaO Shigella dysenteriae Sd197 C32 tRNA thiolase YP_403060.1 1316535 R 300267 CDS YP_403061.1 82776712 3797933 complement(1317522..1317761) 1 NC_007606.1 hypothetical protein 1317761 3797933 SDY_1427 Shigella dysenteriae Sd197 hypothetical protein YP_403061.1 1317522 R 300267 CDS YP_403064.1 82776715 3797936 complement(1319000..1319275) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1319275 insA 3797936 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403064.1 1319000 R 300267 CDS YP_009000708.1 578793171 18263022 1319801..1320073 1 NC_007606.1 insertion element iso-IS1N protein InsA 1320073 18263022 SDY_1430a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000708.1 1319801 D 300267 CDS YP_403065.1 82776716 3796022 1320100..1320495 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1320495 3796022 SDY_1431 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403065.1 1320100 D 300267 CDS YP_403066.1 82776717 3796023 1321016..1321171 1 NC_007606.1 polypeptide destructive to membrane potential 1321171 relF 3796023 relF Shigella dysenteriae Sd197 polypeptide destructive to membrane potential YP_403066.1 1321016 D 300267 CDS YP_403067.1 82776718 3796024 1321388..1321639 1 NC_007606.1 hypothetical protein 1321639 rem 3796024 rem Shigella dysenteriae Sd197 hypothetical protein YP_403067.1 1321388 D 300267 CDS YP_403068.1 82776719 3796025 1321986..1323035 1 NC_007606.1 hypothetical protein 1323035 3796025 SDY_1434 Shigella dysenteriae Sd197 hypothetical protein YP_403068.1 1321986 D 300267 CDS YP_403069.1 82776720 3796026 1323048..1323422 1 NC_007606.1 Code: L; COG: COG4570; endonuclease of prophage CP-933O 1323422 3796026 SDY_1435 Shigella dysenteriae Sd197 endonuclease of prophage CP-933O YP_403069.1 1323048 D 300267 CDS YP_403070.1 82776721 3796027 1323419..1324240 1 NC_007606.1 antitermination protein Q 1324240 3796027 SDY_1436 Shigella dysenteriae Sd197 antitermination protein Q YP_403070.1 1323419 D 300267 CDS YP_403071.1 82776722 3796030 1324726..1325001 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1325001 insA 3796030 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403071.1 1324726 D 300267 CDS YP_403072.1 82776723 3796031 1325046..1325423 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1325423 insB 3796031 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403072.1 1325046 D 300267 CDS YP_009000709.1 578793172 18263023 1325914..1326186 1 NC_007606.1 insertion element iso-IS1N protein InsA 1326186 18263023 SDY_1440a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000709.1 1325914 D 300267 CDS YP_403074.1 82776725 3796033 1326213..1326608 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1326608 3796033 SDY_1442 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403074.1 1326213 D 300267 CDS YP_403075.1 82776726 3796034 1326609..1326815 1 NC_007606.1 hypothetical protein 1326815 3796034 SDY_1443 Shigella dysenteriae Sd197 hypothetical protein YP_403075.1 1326609 D 300267 CDS YP_403076.1 82776727 3796035 1326985..1327287 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1327287 3796035 SDY_1444 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403076.1 1326985 D 300267 CDS YP_403078.1 82776729 3796037 complement(1328535..1328930) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1328930 3796037 SDY_1446 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403078.1 1328535 R 300267 CDS YP_009000710.1 578793173 18263024 complement(1328957..1329229) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1329229 18263024 SDY_1466a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000710.1 1328957 R 300267 CDS YP_403080.1 82776731 3796039 1329300..1329542 1 NC_007606.1 hypothetical protein 1329542 3796039 SDY_1448 Shigella dysenteriae Sd197 hypothetical protein YP_403080.1 1329300 D 300267 CDS YP_403081.1 82776732 3799402 1329900..1330265 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1330265 3799402 SDY_1449 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_403081.1 1329900 D 300267 CDS YP_403082.2 161950123 3799403 1330223..1331128 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1331128 3799403 SDY_1450 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_403082.2 1330223 D 300267 CDS YP_009000711.1 578793174 18263025 1331147..1331362 1 NC_007606.1 phage lysis protein 1331362 18263025 SDY_1450a Shigella dysenteriae Sd197 phage lysis protein YP_009000711.1 1331147 D 300267 CDS YP_009000712.1 578793175 18263026 1331367..1331552 1 NC_007606.1 prophage protein 1331552 18263026 SDY_1451a Shigella dysenteriae Sd197 prophage protein YP_009000712.1 1331367 D 300267 CDS YP_403084.1 82776735 3799405 complement(1332447..1332749) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1332749 3799405 SDY_1452 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403084.1 1332447 R 300267 CDS YP_403086.1 82776737 3799407 complement(1333997..1334854) 1 NC_007606.1 Code: P; COG: COG1108; iron ABC transporter permease 1334854 sitD 3799407 sitD Shigella dysenteriae Sd197 iron ABC transporter permease YP_403086.1 1333997 R 300267 CDS YP_403087.1 82776738 3799408 complement(1334851..1335708) 1 NC_007606.1 Code: P; COG: COG1108; iron ABC transporter permease 1335708 sitC 3799408 sitC Shigella dysenteriae Sd197 iron ABC transporter permease YP_403087.1 1334851 R 300267 CDS YP_403088.1 82776739 3799409 complement(1335705..1336532) 1 NC_007606.1 Code: P; COG: COG1121; iron ABC transporter ATP-binding protein 1336532 sitB 3799409 sitB Shigella dysenteriae Sd197 iron ABC transporter ATP-binding protein YP_403088.1 1335705 R 300267 CDS YP_403089.1 82776740 3799410 complement(1336532..1337446) 1 NC_007606.1 Code: P; COG: COG0803; iron ABC transporter substrate-binding protein 1337446 sitA 3799410 sitA Shigella dysenteriae Sd197 iron ABC transporter substrate-binding protein YP_403089.1 1336532 R 300267 CDS YP_403090.1 82776741 3799411 complement(1338033..1338539) 1 NC_007606.1 Code: T; COG: COG0589; filament protein 1338539 ynaF 3799411 ynaF Shigella dysenteriae Sd197 filament protein YP_403090.1 1338033 R 300267 CDS YP_403091.1 82776742 3799413 complement(1339983..1340696) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1340696 3799413 SDY_1460 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_403091.1 1339983 R 300267 CDS YP_403092.1 82776743 3799414 complement(1341364..1344888) 1 NC_007606.1 Code: C; COG: COG0674; oxidoreductase Fe-S subunit 1344888 ydbK 3799414 ydbK Shigella dysenteriae Sd197 oxidoreductase Fe-S subunit YP_403092.1 1341364 R 300267 CDS YP_403093.1 82776744 3799415 1345150..1345416 1 NC_007606.1 Code: R; COG: COG3042; hypothetical protein 1345416 3799415 SDY_1462 Shigella dysenteriae Sd197 hypothetical protein YP_403093.1 1345150 D 300267 CDS YP_403094.1 82776745 3799417 complement(1345935..1346924) 1 NC_007606.1 Code: CHR; COG: COG1052; fermentative D-lactate dehydrogenase 1346924 ldhA 3799417 ldhA Shigella dysenteriae Sd197 fermentative D-lactate dehydrogenase YP_403094.1 1345935 R 300267 CDS YP_403095.1 82776746 3799418 1347132..1349771 1 NC_007606.1 hypothetical protein 1349771 ydbH 3799418 ydbH Shigella dysenteriae Sd197 hypothetical protein YP_403095.1 1347132 D 300267 CDS YP_403096.1 82776747 3799419 1349768..1349953 1 NC_007606.1 hypothetical protein 1349953 ynbE 3799419 ynbE Shigella dysenteriae Sd197 hypothetical protein YP_403096.1 1349768 D 300267 CDS YP_009000713.1 578793176 18263027 1350245..1350517 1 NC_007606.1 insertion element iso-IS1N protein InsA 1350517 18263027 SDY_1468a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000713.1 1350245 D 300267 CDS YP_403098.1 82776749 3797988 1350544..1350939 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1350939 3797988 SDY_1468 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403098.1 1350544 D 300267 CDS YP_403099.1 82776750 3797989 1351167..1351442 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1351442 insA 3797989 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403099.1 1351167 D 300267 CDS YP_403100.1 82776751 3797990 1351487..1351864 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1351864 insB 3797990 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403100.1 1351487 D 300267 CDS YP_403101.1 82776752 3797991 1352005..1352562 1 NC_007606.1 hypothetical protein 1352562 3797991 SDY_1471 Shigella dysenteriae Sd197 hypothetical protein YP_403101.1 1352005 D 300267 CDS YP_403102.1 82776753 3797992 1352732..1353346 1 NC_007606.1 Code: I; COG: COG0558; hypothetical protein 1353346 3797992 SDY_1472 Shigella dysenteriae Sd197 hypothetical protein YP_403102.1 1352732 D 300267 CDS YP_403103.1 82776754 3797993 complement(1353321..1353716) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1353716 3797993 SDY_1473 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403103.1 1353321 R 300267 CDS YP_009000714.1 578793177 18263028 complement(1353743..1354015) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1354015 18263028 SDY_1469a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000714.1 1353743 R 300267 CDS YP_403104.1 82776755 3797994 complement(1354383..1355141) 1 NC_007606.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1355141 aroD 3797994 aroD Shigella dysenteriae Sd197 3-dehydroquinate dehydratase YP_403104.1 1354383 R 300267 CDS YP_403105.1 82776756 3797995 complement(1355172..1356065) 1 NC_007606.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1356065 ydiB 3797995 ydiB Shigella dysenteriae Sd197 quinate/shikimate dehydrogenase YP_403105.1 1355172 R 300267 CDS YP_403106.1 82776757 3797996 complement(1356043..1356258) 1 NC_007606.1 insertion element iso-IS1n protein InsB 1356258 3797996 SDY_1476 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403106.1 1356043 R 300267 CDS YP_009000715.1 578793178 18263029 complement(1356464..1356736) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1356736 18263029 SDY_1476a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000715.1 1356464 R 300267 CDS YP_403107.1 82776758 3797997 complement(1356823..1357176) 1 NC_007606.1 hypothetical protein 1357176 3797997 SDY_1477 Shigella dysenteriae Sd197 hypothetical protein YP_403107.1 1356823 R 300267 CDS YP_403108.1 82776759 3797998 complement(1357273..1357650) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1357650 insB 3797998 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403108.1 1357273 R 300267 CDS YP_403109.1 82776760 3797999 complement(1357695..1357970) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1357970 insA 3797999 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403109.1 1357695 R 300267 CDS YP_403111.1 82776762 3798001 complement(1358895..1359197) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1359197 3798001 SDY_1481 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403111.1 1358895 R 300267 CDS YP_403112.1 82776763 3798002 1359291..1359566 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1359566 insA 3798002 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403112.1 1359291 D 300267 CDS YP_403113.1 82776764 3798003 complement(1359923..1360801) 1 NC_007606.1 Code: GEPR; COG: COG0477; transport system permease 1360801 3798003 SDY_1483 Shigella dysenteriae Sd197 transport system permease YP_403113.1 1359923 R 300267 CDS YP_403114.1 82776765 3798004 complement(1360779..1361174) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1361174 3798004 SDY_1484 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403114.1 1360779 R 300267 CDS YP_009000716.1 578793179 18263030 complement(1361201..1361473) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1361473 18263030 SDY_1482a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000716.1 1361201 R 300267 CDS YP_403115.1 82776766 3798005 1361643..1362389 1 NC_007606.1 Code: M; COG: COG3713; hypothetical protein 1362389 yeaF 3798005 yeaF Shigella dysenteriae Sd197 hypothetical protein YP_403115.1 1361643 D 300267 CDS YP_403116.1 82776767 3798006 1362479..1363330 1 NC_007606.1 Code: R; COG: COG0656; aldehyde reductase 1363330 3798006 SDY_1486 Shigella dysenteriae Sd197 aldehyde reductase YP_403116.1 1362479 D 300267 CDS YP_403117.1 82776768 3798007 complement(1363381..1364286) 1 NC_007606.1 Code: G; COG: COG0676; hypothetical protein 1364286 yeaD 3798007 yeaD Shigella dysenteriae Sd197 hypothetical protein YP_403117.1 1363381 R 300267 CDS YP_403118.1 82776769 3797500 complement(1364349..1365344) 1 NC_007606.1 Code: G; COG: COG0057; glyceraldehyde-3-phosphate dehydrogenase 1365344 gapA 3797500 gapA Shigella dysenteriae Sd197 glyceraldehyde-3-phosphate dehydrogenase YP_403118.1 1364349 R 300267 CDS YP_403119.1 82776770 3797501 1365686..1366099 1 NC_007606.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1366099 yeaA 3797501 yeaA Shigella dysenteriae Sd197 methionine sulfoxide reductase B YP_403119.1 1365686 D 300267 CDS YP_403120.1 82776771 3797502 1366096..1366413 1 NC_007606.1 Code: S; COG: COG3139; hypothetical protein 1366413 3797502 SDY_1490 Shigella dysenteriae Sd197 hypothetical protein YP_403120.1 1366096 D 300267 CDS YP_403121.1 82776772 3797503 1366782..1367858 1 NC_007606.1 Code: ER; COG: COG1063; oxidoreductase 1367858 3797503 SDY_1491 Shigella dysenteriae Sd197 oxidoreductase YP_403121.1 1366782 D 300267 CDS YP_403122.1 82776773 3797504 1367885..1369264 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 1369264 3797504 SDY_1492 Shigella dysenteriae Sd197 transport protein YP_403122.1 1367885 D 300267 CDS YP_403123.1 82776774 3797505 1369320..1370327 1 NC_007606.1 Code: ER; COG: COG1063; oxidoreductase 1370327 ydjJ 3797505 ydjJ Shigella dysenteriae Sd197 oxidoreductase YP_403123.1 1369320 D 300267 CDS YP_403124.1 82776775 3797506 complement(1370684..1370959) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1370959 insA 3797506 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403124.1 1370684 R 300267 CDS YP_403125.1 82776776 3797507 1371015..1371659 1 NC_007606.1 Code: G; COG: COG0524; kinase 1371659 3797507 SDY_1495 Shigella dysenteriae Sd197 kinase YP_403125.1 1371015 D 300267 CDS YP_403128.1 82776779 3797510 1372787..1373545 1 NC_007606.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 1373545 3797510 SDY_1498 Shigella dysenteriae Sd197 DeoR-type transcriptional regulator YP_403128.1 1372787 D 300267 CDS YP_009000717.1 578793180 18263031 1374314..1374586 1 NC_007606.1 insertion element iso-IS1N protein InsA 1374586 18263031 SDY_1500a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000717.1 1374314 D 300267 CDS YP_403130.1 82776781 3797513 1375040..1375315 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1375315 insA 3797513 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403130.1 1375040 D 300267 CDS YP_403131.1 82776782 3797514 1375360..1375737 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1375737 insB 3797514 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403131.1 1375360 D 300267 CDS YP_403132.1 82776783 3797515 complement(1375960..1376355) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1376355 3797515 SDY_1503 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403132.1 1375960 R 300267 CDS YP_009000718.1 578793181 18263032 complement(1376382..1376654) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1376654 18263032 SDY_1503a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000718.1 1376382 R 300267 CDS YP_403134.2 161950122 3797517 complement(1377057..1377698) 1 NC_007606.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1377698 ydjB 3797517 ydjB Shigella dysenteriae Sd197 nicotinamidase/pyrazinamidase YP_403134.2 1377057 R 300267 CDS YP_403135.1 82776786 3797518 complement(1377709..1378725) 1 NC_007606.1 converts asparagine to aspartate and ammonia; asparaginase 1378725 ansA 3797518 ansA Shigella dysenteriae Sd197 asparaginase YP_403135.1 1377709 R 300267 CDS YP_403136.1 82776787 3799324 complement(1378879..1380735) 1 NC_007606.1 signal peptide peptidase; SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1380735 sppA 3799324 sppA Shigella dysenteriae Sd197 protease 4 YP_403136.1 1378879 R 300267 CDS YP_403137.1 82776788 3799325 1380896..1381447 1 NC_007606.1 Code: C; COG: COG0778; hypothetical protein 1381447 ydjA 3799325 ydjA Shigella dysenteriae Sd197 hypothetical protein YP_403137.1 1380896 D 300267 CDS YP_403138.1 82776789 3799326 1381564..1382607 1 NC_007606.1 H(2)Se added to acrylyl-tRNA; catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1382607 selD 3799326 selD Shigella dysenteriae Sd197 selenophosphate synthetase YP_403138.1 1381564 D 300267 CDS YP_403139.1 82776790 3799327 1382612..1384573 1 NC_007606.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1384573 topB 3799327 topB Shigella dysenteriae Sd197 DNA topoisomerase III YP_403139.1 1382612 D 300267 CDS YP_009000719.1 578793182 18263033 1384804..1385076 1 NC_007606.1 insertion element iso-IS1N protein InsA 1385076 18263033 SDY_1512a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000719.1 1384804 D 300267 CDS YP_403141.1 82776792 3799329 complement(1385351..1385746) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1385746 3799329 SDY_1512 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403141.1 1385351 R 300267 CDS YP_009000720.1 578793183 18263034 complement(1385773..1386045) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1386045 18263034 SDY_1513a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000720.1 1385773 R 300267 CDS YP_403142.2 161950121 3799330 1386335..1387288 1 NC_007606.1 hypothetical protein 1387288 3799330 SDY_1513 Shigella dysenteriae Sd197 hypothetical protein YP_403142.2 1386335 D 300267 CDS YP_403143.1 82776794 3799331 complement(1387405..1388748) 1 NC_007606.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1388748 gdhA 3799331 gdhA Shigella dysenteriae Sd197 glutamate dehydrogenase YP_403143.1 1387405 R 300267 CDS YP_403144.1 82776795 3799332 1388984..1389256 1 NC_007606.1 hypothetical protein 1389256 3799332 SDY_1515 Shigella dysenteriae Sd197 hypothetical protein YP_403144.1 1388984 D 300267 CDS YP_403145.1 82776796 3799333 complement(1389222..1389629) 1 NC_007606.1 Code: LR; COG: COG0494; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1389629 3799333 SDY_1516 Shigella dysenteriae Sd197 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_403145.1 1389222 R 300267 CDS YP_403147.1 82776798 3799336 complement(1391718..1392371) 1 NC_007606.1 Code: R; COG: COG4136; ATPase 1392371 3799336 SDY_1519 Shigella dysenteriae Sd197 ATPase YP_403147.1 1391718 R 300267 CDS YP_403151.1 82776802 3799340 complement(1395056..1395604) 1 NC_007606.1 Code: S; COG: COG2128; hypothetical protein 1395604 ynjA 3799340 ynjA Shigella dysenteriae Sd197 hypothetical protein YP_403151.1 1395056 R 300267 CDS YP_403152.1 82776803 3799341 complement(1395604..1396311) 1 NC_007606.1 Code: S; COG: COG0398; hypothetical protein 1396311 ydjZ 3799341 ydjZ Shigella dysenteriae Sd197 hypothetical protein YP_403152.1 1395604 R 300267 CDS YP_403153.1 82776804 3799342 complement(1396326..1397003) 1 NC_007606.1 hypothetical protein 1397003 ydjY 3799342 ydjY Shigella dysenteriae Sd197 hypothetical protein YP_403153.1 1396326 R 300267 CDS YP_403154.1 82776805 3799343 complement(1397008..1397571) 1 NC_007606.1 Code: S; COG: COG0398; hypothetical protein 1397571 ydjX 3799343 ydjX Shigella dysenteriae Sd197 hypothetical protein YP_403154.1 1397008 R 300267 CDS YP_403155.1 82776806 3799016 complement(1397738..1398544) 1 NC_007606.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1398544 xthA 3799016 xthA Shigella dysenteriae Sd197 exonuclease III YP_403155.1 1397738 R 300267 CDS YP_403156.1 82776807 3799018 complement(1400378..1400677) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 1400677 insA 3799018 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_403156.1 1400378 R 300267 CDS YP_403157.1 82776808 3799019 1400983..1402017 1 NC_007606.1 Code: E; COG: COG3138; arginine succinyltransferase 1402017 3799019 SDY_1530 Shigella dysenteriae Sd197 arginine succinyltransferase YP_403157.1 1400983 D 300267 CDS YP_403158.1 82776809 3799020 1402014..1403015 1 NC_007606.1 Code: C; COG: COG1012; aldehyde dehydrogenase 1403015 3799020 SDY_1531 Shigella dysenteriae Sd197 aldehyde dehydrogenase YP_403158.1 1402014 D 300267 CDS YP_403159.2 161950120 3799021 1403484..1404830 1 NC_007606.1 ''catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation''; succinylarginine dihydrolase 1404830 3799021 SDY_1532 Shigella dysenteriae Sd197 succinylarginine dihydrolase YP_403159.2 1403484 D 300267 CDS YP_403161.1 82776812 3799023 1406110..1406595 1 NC_007606.1 periplasmic protein related to spheroblast formation; periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein 1406595 spy 3799023 spy Shigella dysenteriae Sd197 hypothetical protein YP_403161.1 1406110 D 300267 CDS YP_403162.1 82776813 3799024 1406798..1407073 1 NC_007606.1 hypothetical protein 1407073 3799024 SDY_1535 Shigella dysenteriae Sd197 hypothetical protein YP_403162.1 1406798 D 300267 CDS YP_009000721.1 578793184 18263035 complement(1407470..1407742) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1407742 18263035 SDY_1537a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000721.1 1407470 R 300267 CDS YP_403166.1 82776817 3799028 complement(1408108..1408974) 1 NC_007606.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1408974 3799028 SDY_1539 Shigella dysenteriae Sd197 nucleotide excision repair endonuclease YP_403166.1 1408108 R 300267 CDS YP_403167.1 82776818 3799029 complement(1409204..1410031) 1 NC_007606.1 prefers NH3 over glutamine; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1410031 nadE 3799029 nadE Shigella dysenteriae Sd197 NAD synthetase YP_403167.1 1409204 R 300267 CDS YP_403168.1 82776819 3799030 1410233..1410571 1 NC_007606.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1410571 osmE 3799030 osmE Shigella dysenteriae Sd197 DNA-binding transcriptional activator OsmE YP_403168.1 1410233 D 300267 CDS YP_009000722.1 578793185 18263036 1410800..1411072 1 NC_007606.1 insertion element iso-IS1N protein InsA 1411072 18263036 SDY_1541a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000722.1 1410800 D 300267 CDS YP_403169.1 82776820 3799031 1411099..1411494 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1411494 3799031 SDY_1542 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403169.1 1411099 D 300267 CDS YP_403171.1 82776822 3799033 1413278..1413553 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1413553 insA 3799033 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403171.1 1413278 D 300267 CDS YP_403172.1 82776823 3799034 1413598..1413975 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1413975 insB 3799034 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403172.1 1413598 D 300267 CDS YP_403173.1 82776824 3796423 1414088..1414423 1 NC_007606.1 Code: R; COG: COG3136; hypothetical protein 1414423 ydgC 3796423 ydgC Shigella dysenteriae Sd197 hypothetical protein YP_403173.1 1414088 D 300267 CDS YP_403174.1 82776825 3796424 complement(1414420..1415142) 1 NC_007606.1 Code: IQR; COG: COG1028; short chain dehydrogenase 1415142 ydgB 3796424 ydgB Shigella dysenteriae Sd197 short chain dehydrogenase YP_403174.1 1414420 R 300267 CDS YP_403175.1 82776826 3796425 complement(1415179..1416561) 1 NC_007606.1 Code: E; COG: COG0531; arginine/ornithine antiporter 1416561 3796425 SDY_1548 Shigella dysenteriae Sd197 arginine/ornithine antiporter YP_403175.1 1415179 R 300267 CDS YP_403176.1 82776827 3796426 complement(1416747..1417691) 1 NC_007606.1 hypothetical protein 1417691 3796426 SDY_1549 Shigella dysenteriae Sd197 hypothetical protein YP_403176.1 1416747 R 300267 CDS YP_403177.1 82776828 3796427 1418215..1419747 1 NC_007606.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1419747 pntA 3796427 pntA Shigella dysenteriae Sd197 NAD(P) transhydrogenase subunit alpha YP_403177.1 1418215 D 300267 CDS YP_403178.1 82776829 3796428 1419758..1421146 1 NC_007606.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1421146 pntB 3796428 pntB Shigella dysenteriae Sd197 pyridine nucleotide transhydrogenase YP_403178.1 1419758 D 300267 CDS YP_403179.1 82776830 3796429 complement(1421171..1422205) 1 NC_007606.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transport protein 1422205 tqsA 3796429 tqsA Shigella dysenteriae Sd197 transport protein YP_403179.1 1421171 R 300267 CDS YP_403180.1 82776831 3796430 1422617..1422982 1 NC_007606.1 ''with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS''; multidrug efflux system protein MdtJ 1422982 3796430 SDY_1553 Shigella dysenteriae Sd197 multidrug efflux system protein MdtJ YP_403180.1 1422617 D 300267 CDS YP_403181.1 82776832 3796431 1422969..1423298 1 NC_007606.1 ''with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS''; multidrug efflux system protein MdtI 1423298 3796431 SDY_1554 Shigella dysenteriae Sd197 multidrug efflux system protein MdtI YP_403181.1 1422969 D 300267 CDS YP_403182.1 82776833 3796432 complement(1423337..1424158) 1 NC_007606.1 Code: E; COG: COG3591; hypothetical protein 1424158 3796432 SDY_1555 Shigella dysenteriae Sd197 hypothetical protein YP_403182.1 1423337 R 300267 CDS YP_403183.2 161950119 3796433 complement(1424434..1424742) 1 NC_007606.1 required for growth and survival under moderately acid conditions; acid shock protein 1424742 asr 3796433 asr Shigella dysenteriae Sd197 acid shock protein YP_403183.2 1424434 R 300267 CDS YP_009000723.1 578793186 18263037 1425129..1425401 1 NC_007606.1 insertion element iso-IS1N protein InsA 1425401 18263037 SDY_1556a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000723.1 1425129 D 300267 CDS YP_403187.1 82776838 3796437 1427626..1428003 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1428003 insB 3796437 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403187.1 1427626 D 300267 CDS YP_403188.1 82776839 3796438 1428076..1428969 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1428969 ynfL 3796438 ynfL Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_403188.1 1428076 D 300267 CDS YP_403189.1 82776840 3796439 1429104..1430324 1 NC_007606.1 Code: KG; COG: COG1940; NAGC-like transcriptional regulator 1430324 mlc 3796439 mlc Shigella dysenteriae Sd197 NAGC-like transcriptional regulator YP_403189.1 1429104 D 300267 CDS YP_403190.2 161950118 3796440 1430449..1431144 1 NC_007606.1 ''DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium''; dithiobiotin synthetase 1431144 3796440 SDY_1563 Shigella dysenteriae Sd197 dithiobiotin synthetase YP_403190.2 1430449 D 300267 CDS YP_403191.1 82776842 3796441 complement(1431097..1432434) 1 NC_007606.1 Code: P; COG: COG0038; voltage-gated ClC-type chloride channel ClcB 1432434 3796441 SDY_1564 Shigella dysenteriae Sd197 voltage-gated ClC-type chloride channel ClcB YP_403191.1 1431097 R 300267 CDS YP_403192.1 82776843 3797106 complement(1433204..1434058) 1 NC_007606.1 Code: R; COG: COG3302; DMSO reductase anchor subunit 1434058 3797106 SDY_1566 Shigella dysenteriae Sd197 DMSO reductase anchor subunit YP_403192.1 1433204 R 300267 CDS YP_403193.1 82776844 3797107 complement(1434060..1434677) 1 NC_007606.1 Code: C; COG: COG0437; oxidoreductase Fe-S subunit 1434677 3797107 SDY_1567 Shigella dysenteriae Sd197 oxidoreductase Fe-S subunit YP_403193.1 1434060 R 300267 CDS YP_403194.1 82776845 3797110 complement(1439771..1440118) 1 NC_007606.1 hypothetical protein 1440118 3797110 SDY_1570 Shigella dysenteriae Sd197 hypothetical protein YP_403194.1 1439771 R 300267 CDS YP_403195.2 161950117 3797111 1440184..1440894 1 NC_007606.1 hypothetical protein 1440894 ynfC 3797111 ynfC Shigella dysenteriae Sd197 hypothetical protein YP_403195.2 1440184 D 300267 CDS YP_403196.1 82776847 3797112 1440894..1441106 1 NC_007606.1 hypothetical protein 1441106 3797112 SDY_1572 Shigella dysenteriae Sd197 hypothetical protein YP_403196.1 1440894 D 300267 CDS YP_009000724.1 578793187 18263038 1441142..1441414 1 NC_007606.1 insertion element iso-IS1N protein InsA 1441414 18263038 SDY_1572a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000724.1 1441142 D 300267 CDS YP_403198.1 82776849 3797114 1441441..1441836 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1441836 3797114 SDY_1574 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403198.1 1441441 D 300267 CDS YP_403199.1 82776850 3797116 complement(1442266..1442607) 1 NC_007606.1 hypothetical protein 1442607 3797116 SDY_1576 Shigella dysenteriae Sd197 hypothetical protein YP_403199.1 1442266 R 300267 CDS YP_403200.1 82776851 3797117 1442742..1443068 1 NC_007606.1 Code: S; COG: COG1742; hypothetical protein 1443068 3797117 SDY_1577 Shigella dysenteriae Sd197 hypothetical protein YP_403200.1 1442742 D 300267 CDS YP_403201.1 82776852 3797120 complement(1445214..1445609) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1445609 3797120 SDY_1580 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403201.1 1445214 R 300267 CDS YP_009000725.1 578793188 18263039 complement(1445636..1445908) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1445908 18263039 SDY_1580a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000725.1 1445636 R 300267 CDS YP_403203.1 82776854 3797122 1446435..1447718 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 1447718 3797122 SDY_1582 Shigella dysenteriae Sd197 transport protein YP_403203.1 1446435 D 300267 CDS YP_403204.1 82776855 3797124 complement(1449303..1449506) 1 NC_007606.1 hypothetical protein 1449506 3797124 SDY_1584 Shigella dysenteriae Sd197 hypothetical protein YP_403204.1 1449303 R 300267 CDS YP_403205.1 82776856 3796899 complement(1449683..1450369) 1 NC_007606.1 Code: K; COG: COG1802; hypothetical protein 1450369 ydfH 3796899 ydfH Shigella dysenteriae Sd197 hypothetical protein YP_403205.1 1449683 R 300267 CDS YP_403206.1 82776857 3796900 complement(1450458..1451204) 1 NC_007606.1 ''NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine''; 3-hydroxy acid dehydrogenase 1451204 ydfG 3796900 ydfG Shigella dysenteriae Sd197 3-hydroxy acid dehydrogenase YP_403206.1 1450458 R 300267 CDS YP_403207.1 82776858 3796901 1451341..1453386 1 NC_007606.1 Code: E; COG: COG0339; dipeptidyl carboxypeptidase II 1453386 dcp 3796901 dcp Shigella dysenteriae Sd197 dipeptidyl carboxypeptidase II YP_403207.1 1451341 D 300267 CDS YP_403208.1 82776859 3796902 complement(1453431..1453949) 1 NC_007606.1 Code: R; COG: COG1546; competence damage-inducible protein A 1453949 ydeJ 3796902 ydeJ Shigella dysenteriae Sd197 competence damage-inducible protein A YP_403208.1 1453431 R 300267 CDS YP_403209.1 82776860 3796903 1454225..1454617 1 NC_007606.1 Code: S; COG: COG3111; hypothetical protein 1454617 ydeI 3796903 ydeI Shigella dysenteriae Sd197 hypothetical protein YP_403209.1 1454225 D 300267 CDS YP_403210.1 82776861 3796904 1454872..1455762 1 NC_007606.1 Code: T; COG: COG2199; hypothetical protein 1455762 ydeH 3796904 ydeH Shigella dysenteriae Sd197 hypothetical protein YP_403210.1 1454872 D 300267 CDS YP_403211.1 82776862 3796905 1456170..1456445 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1456445 insA 3796905 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403211.1 1456170 D 300267 CDS YP_403212.1 82776863 3796906 1456490..1456867 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1456867 insB 3796906 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403212.1 1456490 D 300267 CDS YP_403213.1 82776864 3796907 complement(1456979..1458166) 1 NC_007606.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 1458166 ydeF 3796907 ydeF Shigella dysenteriae Sd197 MFS-type transporter YdeE YP_403213.1 1456979 R 300267 CDS YP_403214.2 161950116 3796908 1458361..1459260 1 NC_007606.1 Code: GER; COG: COG0697; O-acetylserine/cysteine export protein 1459260 ydeD 3796908 ydeD Shigella dysenteriae Sd197 O-acetylserine/cysteine export protein YP_403214.2 1458361 D 300267 CDS YP_403215.2 161950115 3796910 complement(1459540..1459923) 1 NC_007606.1 multiple antibiotic resistance; transcriptional activator of defense systems; ''transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF''; DNA-binding transcriptional activator MarA 1459923 marA 3796910 marA Shigella dysenteriae Sd197 DNA-binding transcriptional activator MarA YP_403215.2 1459540 R 300267 CDS YP_403216.2 161950114 3796911 complement(1459943..1460377) 1 NC_007606.1 multiple antibiotic resistance protein; repressor of mar operon; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1460377 marR 3796911 marR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor MarR YP_403216.2 1459943 R 300267 CDS YP_403217.1 82776868 3796912 1460589..1461254 1 NC_007606.1 ''protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function''; multiple drug resistance protein MarC 1461254 ydeB 3796912 ydeB Shigella dysenteriae Sd197 multiple drug resistance protein MarC YP_403217.1 1460589 D 300267 CDS YP_403218.1 82776869 3796913 complement(1461279..1462337) 1 NC_007606.1 Code: G; COG: COG2814; sugar efflux transporter 1462337 ydeA 3796913 ydeA Shigella dysenteriae Sd197 sugar efflux transporter YP_403218.1 1461279 R 300267 CDS YP_009000726.1 578793189 18263040 1462519..1462791 1 NC_007606.1 insertion element iso-IS1N protein InsA 1462791 18263040 SDY_1599a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000726.1 1462519 D 300267 CDS YP_403220.1 82776871 3796915 1462818..1463213 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1463213 3796915 SDY_1601 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403220.1 1462818 D 300267 CDS YP_403222.1 82776873 3796917 complement(1463784..1464665) 1 NC_007606.1 Code: GER; COG: COG0697; hypothetical protein 1464665 yddG 3796917 yddG Shigella dysenteriae Sd197 hypothetical protein YP_403222.1 1463784 R 300267 CDS YP_403223.1 82776874 3796578 1467969..1468853 1 NC_007606.1 Code: C; COG: COG0437; formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit 1468853 fdnH 3796578 fdnH Shigella dysenteriae Sd197 formate dehydrogenase-N, nitrate-inducible, iron-sulfur beta subunit YP_403223.1 1467969 D 300267 CDS YP_403224.1 82776875 3796579 1468846..1469499 1 NC_007606.1 ''nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase''; formate dehydrogenase-N subunit gamma 1469499 fdnI 3796579 fdnI Shigella dysenteriae Sd197 formate dehydrogenase-N subunit gamma YP_403224.1 1468846 D 300267 CDS YP_403225.1 82776876 3796580 complement(1469727..1470089) 1 NC_007606.1 Code: R; COG: COG3093; hypothetical protein 1470089 yddM 3796580 yddM Shigella dysenteriae Sd197 hypothetical protein YP_403225.1 1469727 R 300267 CDS YP_403226.2 161950113 3796581 complement(1470071..1471168) 1 NC_007606.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1471168 adhP 3796581 adhP Shigella dysenteriae Sd197 alcohol dehydrogenase YP_403226.2 1470071 R 300267 CDS YP_403227.1 82776878 3796583 1472720..1473151 1 NC_007606.1 Code: O; COG: COG1764; osmotically inducible protein 1473151 osmC 3796583 osmC Shigella dysenteriae Sd197 osmotically inducible protein YP_403227.1 1472720 D 300267 CDS YP_403228.1 82776879 3796584 complement(1473207..1474133) 1 NC_007606.1 Code: EP; COG: COG1124; ATPase 1474133 3796584 SDY_1611 Shigella dysenteriae Sd197 ATPase YP_403228.1 1473207 R 300267 CDS YP_403229.1 82776880 3796586 complement(1475496..1476815) 1 NC_007606.1 Code: S; COG: COG1649; hypothetical protein 1476815 3796586 SDY_1613 Shigella dysenteriae Sd197 hypothetical protein YP_403229.1 1475496 R 300267 CDS YP_403230.1 82776881 3796587 complement(1476946..1478481) 1 NC_007606.1 Code: E; COG: COG0531; acid sensitivity protein 1478481 xasA 3796587 xasA Shigella dysenteriae Sd197 acid sensitivity protein YP_403230.1 1476946 R 300267 CDS YP_403231.1 82776882 3796588 complement(1478637..1480037) 1 NC_007606.1 Code: E; COG: COG0076; glutamate decarboxylase 1480037 gadB 3796588 gadB Shigella dysenteriae Sd197 glutamate decarboxylase YP_403231.1 1478637 R 300267 CDS YP_403234.1 82776885 3796591 1481079..1481507 1 NC_007606.1 hypothetical protein 1481507 3796591 SDY_1618 Shigella dysenteriae Sd197 hypothetical protein YP_403234.1 1481079 D 300267 CDS YP_403236.1 82776887 3796593 1482640..1482915 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1482915 insA 3796593 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403236.1 1482640 D 300267 CDS YP_009000727.1 578793190 18263041 1483479..1483706 1 NC_007606.1 insertion element iso-IS1N protein InsA 1483706 18263041 SDY_1622a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000727.1 1483479 D 300267 CDS YP_403239.1 82776890 3796596 1484106..1484918 1 NC_007606.1 Code: G; COG: COG1830; aldolase 1484918 yneB 3796596 yneB Shigella dysenteriae Sd197 aldolase YP_403239.1 1484106 D 300267 CDS YP_403240.1 82776891 3795944 1484942..1485232 1 NC_007606.1 Code: S; COG: COG1359; autoinducer-2 (AI-2) modifying protein LsrG 1485232 3795944 SDY_1624 Shigella dysenteriae Sd197 autoinducer-2 (AI-2) modifying protein LsrG YP_403240.1 1484942 D 300267 CDS YP_403241.1 82776892 3795945 1485289..1486047 1 NC_007606.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1486047 3795945 SDY_1625 Shigella dysenteriae Sd197 trans-aconitate 2-methyltransferase YP_403241.1 1485289 D 300267 CDS YP_403244.1 82776895 3795949 complement(1488678..1490177) 1 NC_007606.1 Code: T; COG: COG2199; hypothetical protein 1490177 3795949 SDY_1629 Shigella dysenteriae Sd197 hypothetical protein YP_403244.1 1488678 R 300267 CDS YP_403245.1 82776896 3795950 complement(1490316..1490675) 1 NC_007606.1 hypothetical protein 1490675 3795950 SDY_1630 Shigella dysenteriae Sd197 hypothetical protein YP_403245.1 1490316 R 300267 CDS YP_403246.1 82776897 3795951 complement(1490675..1491601) 1 NC_007606.1 catalyzes the formation of glutamate from glutamine; glutaminase 1491601 yneH 3795951 yneH Shigella dysenteriae Sd197 glutaminase YP_403246.1 1490675 R 300267 CDS YP_403247.1 82776898 3795952 complement(1491665..1493077) 1 NC_007606.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate-semialdehyde dehydrogenase 1493077 3795952 SDY_1632 Shigella dysenteriae Sd197 succinate-semialdehyde dehydrogenase YP_403247.1 1491665 R 300267 CDS YP_403248.1 82776899 3795953 1493154..1494035 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1494035 yneJ 3795953 yneJ Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_403248.1 1493154 D 300267 CDS YP_403249.1 82776900 3795954 1494113..1494754 1 NC_007606.1 hypothetical protein 1494754 3795954 SDY_1634 Shigella dysenteriae Sd197 hypothetical protein YP_403249.1 1494113 D 300267 CDS YP_403250.1 82776901 3795955 complement(1494751..1495146) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1495146 3795955 SDY_1635 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403250.1 1494751 R 300267 CDS YP_403251.1 82776902 3795956 1495597..1496088 1 NC_007606.1 hypothetical protein 1496088 3795956 SDY_1636 Shigella dysenteriae Sd197 hypothetical protein YP_403251.1 1495597 D 300267 CDS YP_403252.1 82776903 3795957 1496222..1496467 1 NC_007606.1 hypothetical protein 1496467 ymjA 3795957 ymjA Shigella dysenteriae Sd197 hypothetical protein YP_403252.1 1496222 D 300267 CDS YP_403253.1 82776904 3795958 1496780..1498423 1 NC_007606.1 Code: E; COG: COG4166; protein SapA 1498423 sapA 3795958 sapA Shigella dysenteriae Sd197 protein SapA YP_403253.1 1496780 D 300267 CDS YP_403254.1 82776905 3795959 1498420..1499385 1 NC_007606.1 Code: V; COG: COG4168; hypothetical protein 1499385 sapB 3795959 sapB Shigella dysenteriae Sd197 hypothetical protein YP_403254.1 1498420 D 300267 CDS YP_403259.1 82776910 3795847 1506137..1506439 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1506439 3795847 SDY_1644 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403259.1 1506137 D 300267 CDS YP_403260.2 161950112 3795848 complement(1506830..1507735) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1507735 3795848 SDY_1645 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_403260.2 1506830 R 300267 CDS YP_403261.1 82776912 3795849 complement(1507693..1508058) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1508058 3795849 SDY_1646 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_403261.1 1507693 R 300267 CDS YP_403264.1 82776915 3795854 1513880..1515403 1 NC_007606.1 Code: C; COG: COG1140; cryptic nitrate reductase 2 subunit beta 1515403 narY 3795854 narY Shigella dysenteriae Sd197 cryptic nitrate reductase 2 subunit beta YP_403264.1 1513880 D 300267 CDS YP_403265.1 82776916 3795855 1515403..1516098 1 NC_007606.1 Code: C; COG: COG2180; cryptic nitrate reductase 2 subunit delta 1516098 narW 3795855 narW Shigella dysenteriae Sd197 cryptic nitrate reductase 2 subunit delta YP_403265.1 1515403 D 300267 CDS YP_403266.1 82776917 3795856 1516095..1516775 1 NC_007606.1 Code: C; COG: COG2181; cryptic nitrate reductase 2 subunit gamma 1516775 narV 3795856 narV Shigella dysenteriae Sd197 cryptic nitrate reductase 2 subunit gamma YP_403266.1 1516095 D 300267 CDS YP_403267.1 82776918 3795857 1516855..1517748 1 NC_007606.1 Code: R; COG: COG0384; hypothetical protein 1517748 yddE 3795857 yddE Shigella dysenteriae Sd197 hypothetical protein YP_403267.1 1516855 D 300267 CDS YP_009000728.1 578793191 18263042 1518522..1518794 1 NC_007606.1 insertion element iso-IS1N protein InsA 1518794 18263042 SDY_1654a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000728.1 1518522 D 300267 CDS YP_403269.1 82776920 3795860 1519195..1519872 1 NC_007606.1 adhesin 1519872 3795860 SDY_1657 Shigella dysenteriae Sd197 adhesin YP_403269.1 1519195 D 300267 CDS YP_403270.1 82776921 3795861 1520206..1522485 1 NC_007606.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase 1522485 3795861 SDY_1658 Shigella dysenteriae Sd197 oxidoreductase YP_403270.1 1520206 D 300267 CDS YP_403271.1 82776922 3795862 1522734..1522931 1 NC_007606.1 hypothetical protein 1522931 3795862 SDY_1659 Shigella dysenteriae Sd197 hypothetical protein YP_403271.1 1522734 D 300267 CDS YP_403272.1 82776923 3795863 1523006..1523785 1 NC_007606.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1523785 3795863 SDY_1660 Shigella dysenteriae Sd197 transcriptional regulator YdeO YP_403272.1 1523006 D 300267 CDS YP_403273.1 82776924 3795864 1524172..1524657 1 NC_007606.1 hypothetical protein 1524657 3795864 SDY_1661 Shigella dysenteriae Sd197 hypothetical protein YP_403273.1 1524172 D 300267 CDS YP_403274.1 82776925 3795865 complement(1524905..1525300) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1525300 3795865 SDY_1662 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403274.1 1524905 R 300267 CDS YP_009000729.1 578793192 18263043 complement(1525327..1525599) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1525599 18263043 SDY_1661a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000729.1 1525327 R 300267 CDS YP_403275.1 82776926 3796227 1525712..1526020 1 NC_007606.1 hypothetical protein 1526020 3796227 SDY_1663 Shigella dysenteriae Sd197 hypothetical protein YP_403275.1 1525712 D 300267 CDS YP_009000730.1 578793193 18263044 1528216..1528488 1 NC_007606.1 insertion element iso-IS1N protein InsA 1528488 18263044 SDY_1667a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000730.1 1528216 D 300267 CDS YP_403279.1 82776930 3796231 1528515..1528910 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1528910 3796231 SDY_1667 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403279.1 1528515 D 300267 CDS YP_403280.1 82776931 3796232 1529017..1529355 1 NC_007606.1 hypothetical protein 1529355 3796232 SDY_1668 Shigella dysenteriae Sd197 hypothetical protein YP_403280.1 1529017 D 300267 CDS YP_403281.1 82776932 3796233 complement(1529522..1531258) 1 NC_007606.1 hypothetical protein 1531258 3796233 SDY_1669 Shigella dysenteriae Sd197 hypothetical protein YP_403281.1 1529522 R 300267 CDS YP_403282.1 82776933 3796234 complement(1531311..1532576) 1 NC_007606.1 hypothetical protein 1532576 3796234 SDY_1670 Shigella dysenteriae Sd197 hypothetical protein YP_403282.1 1531311 R 300267 CDS YP_403284.1 82776935 3796236 complement(1533550..1533852) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1533852 3796236 SDY_1672 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403284.1 1533550 R 300267 CDS YP_403285.1 82776936 3796237 complement(1534354..1534623) 1 NC_007606.1 hypothetical protein 1534623 3796237 SDY_1673 Shigella dysenteriae Sd197 hypothetical protein YP_403285.1 1534354 R 300267 CDS YP_403286.1 82776937 3796238 complement(1534642..1535052) 1 NC_007606.1 Code: Q; COG: COG2050; hypothetical protein 1535052 3796238 SDY_1674 Shigella dysenteriae Sd197 hypothetical protein YP_403286.1 1534642 R 300267 CDS YP_403287.1 82776938 3796239 complement(1535049..1538105) 1 NC_007606.1 Code: C; COG: COG0277; oxidase 1538105 ydiJ 3796239 ydiJ Shigella dysenteriae Sd197 oxidase YP_403287.1 1535049 R 300267 CDS YP_403288.1 82776939 3796240 1538494..1539606 1 NC_007606.1 ''YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function''; inner membrane protein 1539606 3796240 SDY_1676 Shigella dysenteriae Sd197 inner membrane protein YP_403288.1 1538494 D 300267 CDS YP_403290.1 82776941 3796242 complement(1540892..1541194) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1541194 3796242 SDY_1678 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403290.1 1540892 R 300267 CDS YP_403291.1 82776942 3796243 1541277..1541660 1 NC_007606.1 hypothetical protein 1541660 3796243 SDY_1679 Shigella dysenteriae Sd197 hypothetical protein YP_403291.1 1541277 D 300267 CDS YP_403292.1 82776943 3796244 complement(1541787..1542182) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1542182 3796244 SDY_1680 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403292.1 1541787 R 300267 CDS YP_009000731.1 578793194 18263045 complement(1542209..1542481) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1542481 18263045 SDY_1682a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000731.1 1542209 R 300267 CDS YP_403294.1 82776945 3796246 1542606..1542986 1 NC_007606.1 hypothetical protein 1542986 3796246 SDY_1682 Shigella dysenteriae Sd197 hypothetical protein YP_403294.1 1542606 D 300267 CDS YP_009000732.1 578793195 18263046 1543026..1543298 1 NC_007606.1 insertion element iso-IS1N protein InsA 1543298 18263046 SDY_1682b Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000732.1 1543026 D 300267 CDS YP_403296.1 82776947 3796248 1543799..1544161 1 NC_007606.1 Code: T; COG: COG2199; hypothetical protein 1544161 3796248 SDY_1684 Shigella dysenteriae Sd197 hypothetical protein YP_403296.1 1543799 D 300267 CDS YP_403297.1 82776948 3796249 1544204..1544707 1 NC_007606.1 Code: S; COG: COG2606; hypothetical protein 1544707 yeaK 3796249 yeaK Shigella dysenteriae Sd197 hypothetical protein YP_403297.1 1544204 D 300267 CDS YP_403298.1 82776949 3796250 complement(1544708..1544860) 1 NC_007606.1 hypothetical protein 1544860 3796250 SDY_1686 Shigella dysenteriae Sd197 hypothetical protein YP_403298.1 1544708 R 300267 CDS YP_403299.1 82776950 3796251 1544982..1545428 1 NC_007606.1 Code: S; COG: COG2707; hypothetical protein 1545428 yeaL 3796251 yeaL Shigella dysenteriae Sd197 hypothetical protein YP_403299.1 1544982 D 300267 CDS YP_403300.1 82776951 3796252 complement(1545385..1546206) 1 NC_007606.1 Code: K; COG: COG2207; AraC family transcriptional regulator 1546206 yeaM 3796252 yeaM Shigella dysenteriae Sd197 AraC family transcriptional regulator YP_403300.1 1545385 R 300267 CDS YP_403301.1 82776952 3796253 1546303..1547484 1 NC_007606.1 Code: P; COG: COG2807; amino acid/amine transport protein 1547484 yeaN 3796253 yeaN Shigella dysenteriae Sd197 amino acid/amine transport protein YP_403301.1 1546303 D 300267 CDS YP_403302.1 82776953 3796254 1547518..1547886 1 NC_007606.1 Code: S; COG: COG3189; hypothetical protein 1547886 yeaO 3796254 yeaO Shigella dysenteriae Sd197 hypothetical protein YP_403302.1 1547518 D 300267 CDS YP_403303.1 82776954 3796255 complement(1547908..1548162) 1 NC_007606.1 Code: R; COG: COG3042; hypothetical protein 1548162 yoaF 3796255 yoaF Shigella dysenteriae Sd197 hypothetical protein YP_403303.1 1547908 R 300267 CDS YP_403304.1 82776955 3796256 1548216..1549370 1 NC_007606.1 Code: T; COG: COG2203; hypothetical protein 1549370 yeaP 3796256 yeaP Shigella dysenteriae Sd197 hypothetical protein YP_403304.1 1548216 D 300267 CDS YP_403305.2 161950111 3796257 complement(1549529..1549924) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1549924 3796257 SDY_1693 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403305.2 1549529 R 300267 CDS YP_009000733.1 578793196 18263047 complement(1549951..1550223) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1550223 18263047 SDY_1695a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000733.1 1549951 R 300267 CDS YP_403307.1 82776958 3796259 complement(1550411..1550659) 1 NC_007606.1 Code: S; COG: COG2261; hypothetical protein 1550659 yeaQ 3796259 yeaQ Shigella dysenteriae Sd197 hypothetical protein YP_403307.1 1550411 R 300267 CDS YP_403308.1 82776959 3796260 complement(1550807..1550989) 1 NC_007606.1 hypothetical protein 1550989 yoaG 3796260 yoaG Shigella dysenteriae Sd197 hypothetical protein YP_403308.1 1550807 R 300267 CDS YP_403309.1 82776960 3796261 complement(1550993..1551352) 1 NC_007606.1 Code: P; COG: COG3615; hypothetical protein 1551352 yeaR 3796261 yeaR Shigella dysenteriae Sd197 hypothetical protein YP_403309.1 1550993 R 300267 CDS YP_403310.1 82776961 3796262 complement(1551525..1552163) 1 NC_007606.1 Code: E; COG: COG1280; leucine export protein LeuE 1552163 yeaS 3796262 yeaS Shigella dysenteriae Sd197 leucine export protein LeuE YP_403310.1 1551525 R 300267 CDS YP_403311.1 82776962 3796263 complement(1552263..1552658) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1552658 3796263 SDY_1699 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403311.1 1552263 R 300267 CDS YP_009000734.1 578793197 18263048 complement(1552686..1552958) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1552958 18263048 SDY_1699a Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000734.1 1552686 R 300267 CDS YP_403312.1 82776963 3796264 complement(1553027..1553971) 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1553971 yeaT 3796264 yeaT Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_403312.1 1553027 R 300267 CDS YP_403313.1 82776964 3796265 1554053..1555138 1 NC_007606.1 Code: CE; COG: COG0473; tartrate dehydrogenase 1555138 yeaU 3796265 yeaU Shigella dysenteriae Sd197 tartrate dehydrogenase YP_403313.1 1554053 D 300267 CDS YP_403314.1 82776965 3796266 1555389..1555604 1 NC_007606.1 hypothetical protein 1555604 3796266 SDY_1702 Shigella dysenteriae Sd197 hypothetical protein YP_403314.1 1555389 D 300267 CDS YP_403316.1 82776967 3796268 1555926..1556321 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1556321 3796268 SDY_1704 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403316.1 1555926 D 300267 CDS YP_403317.1 82776968 3796270 1557775..1558899 1 NC_007606.1 Code: PR; COG: COG4638; hypothetical protein 1558899 yeaW 3796270 yeaW Shigella dysenteriae Sd197 hypothetical protein YP_403317.1 1557775 D 300267 CDS YP_403318.1 82776969 3796271 1558955..1559920 1 NC_007606.1 Code: C; COG: COG1018; diogenase subunit beta 1559920 yeaX 3796271 yeaX Shigella dysenteriae Sd197 diogenase subunit beta YP_403318.1 1558955 D 300267 CDS YP_403319.1 82776970 3796272 complement(1559974..1561101) 1 NC_007606.1 processes tRNA precursor; Code: J; COG: COG0349; ribonuclease D 1561101 rnd 3796272 rnd Shigella dysenteriae Sd197 ribonuclease D YP_403319.1 1559974 R 300267 CDS YP_403320.1 82776971 3796273 complement(1561171..1562856) 1 NC_007606.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1562856 fadD 3796273 fadD Shigella dysenteriae Sd197 long-chain-fatty-acid--CoA ligase YP_403320.1 1561171 R 300267 CDS YP_403321.1 82776972 3796274 complement(1563061..1563642) 1 NC_007606.1 Code: M; COG: COG3065; outer membrane protein 1563642 3796274 SDY_1710 Shigella dysenteriae Sd197 outer membrane protein YP_403321.1 1563061 R 300267 CDS YP_403322.1 82776973 3796275 complement(1563682..1564377) 1 NC_007606.1 Code: O; COG: COG1214; hypothetical protein 1564377 yeaZ 3796275 yeaZ Shigella dysenteriae Sd197 hypothetical protein YP_403322.1 1563682 R 300267 CDS YP_403323.1 82776974 3796276 complement(1564435..1566345) 1 NC_007606.1 Code: KL; COG: COG1199; DNA helicase 1566345 3796276 SDY_1712 Shigella dysenteriae Sd197 DNA helicase YP_403323.1 1564435 R 300267 CDS YP_403324.1 82776975 3796277 1566429..1566821 1 NC_007606.1 Code: J; COG: COG0251; hypothetical protein 1566821 3796277 SDY_1713 Shigella dysenteriae Sd197 hypothetical protein YP_403324.1 1566429 D 300267 CDS YP_403325.1 82776976 3796278 1567023..1567298 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1567298 insA 3796278 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403325.1 1567023 D 300267 CDS YP_403326.1 82776977 3796279 1567343..1567720 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1567720 insB 3796279 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403326.1 1567343 D 300267 CDS YP_403328.1 82776979 3796281 complement(1568439..1568618) 1 NC_007606.1 Code: S; COG: COG3140; hypothetical protein 1568618 3796281 SDY_1717 Shigella dysenteriae Sd197 hypothetical protein YP_403328.1 1568439 R 300267 CDS YP_403329.1 82776980 3796282 1568692..1570053 1 NC_007606.1 Code: EH; COG: COG0147; para-aminobenzoate synthase component I 1570053 pabB 3796282 pabB Shigella dysenteriae Sd197 para-aminobenzoate synthase component I YP_403329.1 1568692 D 300267 CDS YP_403330.1 82776981 3796283 1570057..1570635 1 NC_007606.1 Code: LR; COG: COG0494; hypothetical protein 1570635 yeaB 3796283 yeaB Shigella dysenteriae Sd197 hypothetical protein YP_403330.1 1570057 D 300267 CDS YP_403331.1 82776982 3796284 1570819..1572183 1 NC_007606.1 Code: E; COG: COG1760; L-serine deaminase 1572183 sdaA 3796284 sdaA Shigella dysenteriae Sd197 L-serine deaminase YP_403331.1 1570819 D 300267 CDS YP_403332.1 82776983 3796285 1572553..1572828 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1572828 insA 3796285 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403332.1 1572553 D 300267 CDS YP_403333.1 82776984 3796286 1572873..1573250 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1573250 insB 3796286 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403333.1 1572873 D 300267 CDS YP_403334.1 82776985 3796287 complement(1573185..1573496) 1 NC_007606.1 hypothetical protein 1573496 3796287 SDY_1723 Shigella dysenteriae Sd197 hypothetical protein YP_403334.1 1573185 R 300267 CDS YP_403335.1 82776986 3796288 complement(1573694..1574824) 1 NC_007606.1 Code: R; COG: COG2130; oxidoreductase 1574824 yncB 3796288 yncB Shigella dysenteriae Sd197 oxidoreductase YP_403335.1 1573694 R 300267 CDS YP_403336.1 82776987 3796289 1574909..1575427 1 NC_007606.1 Code: M; COG: COG1247; resistance protein 1575427 3796289 SDY_1725 Shigella dysenteriae Sd197 resistance protein YP_403336.1 1574909 D 300267 CDS YP_403337.1 82776988 3796290 1575424..1575873 1 NC_007606.1 Code: S; COG: COG3238; hypothetical protein 1575873 3796290 SDY_1726 Shigella dysenteriae Sd197 hypothetical protein YP_403337.1 1575424 D 300267 CDS YP_403338.1 82776989 3796291 complement(1576053..1576448) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1576448 3796291 SDY_1727 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403338.1 1576053 R 300267 CDS YP_009000735.1 578793198 18263049 complement(1576475..1576747) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1576747 18263049 SDY_4665 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000735.1 1576475 R 300267 CDS YP_403340.2 578793199 3796293 complement(1576967..1577140) 1 NC_007606.1 hypothetical protein 1577140 3796293 SDY_1729 Shigella dysenteriae Sd197 hypothetical protein YP_403340.2 1576967 R 300267 CDS YP_403341.1 82776992 3796294 complement(1577527..1578951) 1 NC_007606.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1578951 3796294 SDY_1730 Shigella dysenteriae Sd197 gamma-aminobutyraldehyde dehydrogenase YP_403341.1 1577527 R 300267 CDS YP_403342.1 82776993 3796297 complement(1580610..1581623) 1 NC_007606.1 Code: E; COG: COG3842; ATPase 1581623 3796297 SDY_1733 Shigella dysenteriae Sd197 ATPase YP_403342.1 1580610 R 300267 CDS YP_403343.1 82776994 3796298 complement(1581641..1582786) 1 NC_007606.1 Code: E; COG: COG0687; transport protein 1582786 3796298 SDY_1734 Shigella dysenteriae Sd197 transport protein YP_403343.1 1581641 R 300267 CDS YP_403344.1 82776995 3796299 complement(1583031..1584437) 1 NC_007606.1 multi modular; also ATP-binding component of a transport system; Code: KE; COG: COG1167; transcriptional regulator 1584437 3796299 SDY_1735 Shigella dysenteriae Sd197 transcriptional regulator YP_403344.1 1583031 R 300267 CDS YP_403345.1 82776996 3796300 complement(1584516..1584953) 1 NC_007606.1 Code: S; COG: COG1598; hypothetical protein 1584953 3796300 SDY_1736 Shigella dysenteriae Sd197 hypothetical protein YP_403345.1 1584516 R 300267 CDS YP_403347.1 82776998 3796302 complement(1585246..1585641) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1585641 3796302 SDY_1738 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403347.1 1585246 R 300267 CDS YP_009000736.1 578793200 18263050 complement(1585668..1585940) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1585940 18263050 SDY_4666 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000736.1 1585668 R 300267 CDS YP_403349.1 82777000 3796304 complement(1586198..1587835) 1 NC_007606.1 Code: O; COG: COG0826; collagenase 1587835 ydcP 3796304 ydcP Shigella dysenteriae Sd197 collagenase YP_403349.1 1586198 R 300267 CDS YP_403350.1 82777001 3796306 complement(1587866..1588402) 1 NC_007606.1 Code: K; COG: COG1396; hypothetical protein 1588402 ydcN 3796306 ydcN Shigella dysenteriae Sd197 hypothetical protein YP_403350.1 1587866 R 300267 CDS YP_403352.1 82777003 3796308 complement(1589902..1590279) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1590279 insB 3796308 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403352.1 1589902 R 300267 CDS YP_403353.1 82777004 3796309 complement(1590324..1590599) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1590599 insA 3796309 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403353.1 1590324 R 300267 CDS YP_403354.1 82777005 3796310 complement(1590628..1590966) 1 NC_007606.1 hypothetical protein 1590966 3796310 SDY_1746 Shigella dysenteriae Sd197 hypothetical protein YP_403354.1 1590628 R 300267 CDS YP_403355.1 82777006 3796311 complement(1591269..1591862) 1 NC_007606.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1591862 tehB 3796311 tehB Shigella dysenteriae Sd197 tellurite resistance protein TehB YP_403355.1 1591269 R 300267 CDS YP_403356.1 82777007 3796312 complement(1591859..1592839) 1 NC_007606.1 Code: P; COG: COG1275; potassium-tellurite ethidium and proflavin transporter 1592839 tehA 3796312 tehA Shigella dysenteriae Sd197 potassium-tellurite ethidium and proflavin transporter YP_403356.1 1591859 R 300267 CDS YP_403359.1 82777010 3796315 complement(1593936..1594475) 1 NC_007606.1 acetylation of N-terminal serine of 30S ribosomal subunit protein L7; Code: J; COG: COG1670; ribosomal-protein-L7/L12-serine acetyltransferase 1594475 rimL 3796315 rimL Shigella dysenteriae Sd197 ribosomal-protein-L7/L12-serine acetyltransferase YP_403359.1 1593936 R 300267 CDS YP_403360.1 82777011 3796316 complement(1594538..1594705) 1 NC_007606.1 Code: S; COG: COG2841; hypothetical protein 1594705 ydcH 3796316 ydcH Shigella dysenteriae Sd197 hypothetical protein YP_403360.1 1594538 R 300267 CDS YP_403361.1 82777012 3796317 1594803..1595078 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1595078 insA 3796317 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403361.1 1594803 D 300267 CDS YP_403362.1 82777013 3796318 1595123..1595500 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1595500 insB 3796318 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403362.1 1595123 D 300267 CDS YP_403364.1 82777015 3796320 complement(1595679..1597334) 1 NC_007606.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1597334 mdoD 3796320 mdoD Shigella dysenteriae Sd197 glucan biosynthesis protein D YP_403364.1 1595679 R 300267 CDS YP_403365.1 82777016 3796321 complement(1597559..1598902) 1 NC_007606.1 Code: S; COG: COG5383; hypothetical protein 1598902 3796321 SDY_1757 Shigella dysenteriae Sd197 hypothetical protein YP_403365.1 1597559 R 300267 CDS YP_403366.1 82777017 3796322 1598978..1600033 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1600033 3796322 SDY_1758 Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_403366.1 1598978 D 300267 CDS YP_009000737.1 578793201 18263051 1600069..1600341 1 NC_007606.1 insertion element iso-IS1N protein InsA 1600341 18263051 SDY_4667 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000737.1 1600069 D 300267 CDS YP_403367.1 82777018 3796323 1600368..1600763 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1600763 3796323 SDY_1759 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403367.1 1600368 D 300267 CDS YP_403368.1 82777019 3796324 complement(1600836..1602269) 1 NC_007606.1 ribose sensor receptor; Code: NT; COG: COG0840; methyl-accepting chemotaxis protein III 1602269 trg 3796324 trg Shigella dysenteriae Sd197 methyl-accepting chemotaxis protein III YP_403368.1 1600836 R 300267 CDS YP_403369.1 82777020 3796325 complement(1602320..1602715) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1602715 3796325 SDY_1761 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403369.1 1602320 R 300267 CDS YP_009000738.1 578793202 18263052 complement(1602742..1603014) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1603014 18263052 SDY_4668 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000738.1 1602742 R 300267 CDS YP_403370.1 82777021 3796326 1603591..1603758 1 NC_007606.1 hypothetical protein 1603758 3796326 SDY_1762 Shigella dysenteriae Sd197 hypothetical protein YP_403370.1 1603591 D 300267 CDS YP_403371.1 82777022 3796327 complement(1603870..1604043) 1 NC_007606.1 hypothetical protein 1604043 ydcA 3796327 ydcA Shigella dysenteriae Sd197 hypothetical protein YP_403371.1 1603870 R 300267 CDS YP_403372.2 161950110 3796328 complement(1604288..1604818) 1 NC_007606.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1604818 cybB 3796328 cybB Shigella dysenteriae Sd197 cytochrome b561 YP_403372.2 1604288 R 300267 CDS YP_403374.1 82777025 3796332 complement(1607962..1608264) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1608264 3796332 SDY_1768 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403374.1 1607962 R 300267 CDS YP_403375.1 82777026 3796333 complement(1609012..1609227) 1 NC_007606.1 insertion element iso-IS1n protein InsB 1609227 3796333 SDY_1769 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403375.1 1609012 R 300267 CDS YP_009000739.1 578793203 18263053 complement(1609434..1609706) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1609706 18263053 SDY_4669 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000739.1 1609434 R 300267 CDS YP_403376.1 82777027 3796334 complement(1609746..1610159) 1 NC_007606.1 hypothetical protein 1610159 3796334 SDY_1770 Shigella dysenteriae Sd197 hypothetical protein YP_403376.1 1609746 R 300267 CDS YP_403377.1 82777028 3796335 1610390..1610665 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1610665 insA 3796335 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403377.1 1610390 D 300267 CDS YP_403378.1 82777029 3796336 1610710..1611087 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1611087 insB 3796336 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403378.1 1610710 D 300267 CDS YP_403380.1 82777031 3796338 complement(1611837..1615682) 1 NC_007606.1 ''involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain''; ATP-dependent RNA helicase HrpA 1615682 hrpA 3796338 hrpA Shigella dysenteriae Sd197 ATP-dependent RNA helicase HrpA YP_403380.1 1611837 R 300267 CDS YP_403381.1 82777032 3796339 1615940..1616545 1 NC_007606.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1616545 acpD 3796339 acpD Shigella dysenteriae Sd197 azoreductase YP_403381.1 1615940 D 300267 CDS YP_403382.1 82777033 3796340 complement(1616599..1617624) 1 NC_007606.1 Code: I; COG: COG0671; protein YnbD 1617624 ynbD 3796340 ynbD Shigella dysenteriae Sd197 protein YnbD YP_403382.1 1616599 R 300267 CDS YP_403383.1 82777034 3796341 complement(1617624..1617860) 1 NC_007606.1 hypothetical protein 1617860 3796341 SDY_1777 Shigella dysenteriae Sd197 hypothetical protein YP_403383.1 1617624 R 300267 CDS YP_009000740.1 578793204 18263054 1617756..1618028 1 NC_007606.1 insertion element iso-IS1N protein InsA 1618028 18263054 SDY_4670 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000740.1 1617756 D 300267 CDS YP_403384.1 82777035 3796342 1618055..1618450 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1618450 3796342 SDY_1778 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403384.1 1618055 D 300267 CDS YP_403385.1 82777036 3796343 complement(1618679..1620436) 1 NC_007606.1 Code: QR; COG: COG0500; hypothetical protein 1620436 3796343 SDY_1779 Shigella dysenteriae Sd197 hypothetical protein YP_403385.1 1618679 R 300267 CDS YP_009000741.1 578793205 18263055 complement(1621773..1622045) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1622045 18263055 SDY_4671 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000741.1 1621773 R 300267 CDS YP_403388.2 161950109 3796191 1622393..1623544 1 NC_007606.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 1623544 3796191 SDY_1783 Shigella dysenteriae Sd197 acyl-CoA dehydrogenase YP_403388.2 1622393 D 300267 CDS YP_403389.1 82777040 3796192 complement(1623587..1624720) 1 NC_007606.1 Code: L; COG: COG2801; fused IS600 integrase core domain-containing protein/HTH-type transcriptional regulator 1624720 3796192 SDY_1784 Shigella dysenteriae Sd197 fused IS600 integrase core domain-containing protein/HTH-type transcriptional regulator YP_403389.1 1623587 R 300267 CDS YP_403390.1 82777041 3796193 complement(1624861..1625163) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1625163 3796193 SDY_1785 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403390.1 1624861 R 300267 CDS YP_403391.1 82777042 3796194 complement(1625225..1625767) 1 NC_007606.1 Code: K; COG: COG2207; AraC family transcriptional regulator 1625767 3796194 SDY_1786 Shigella dysenteriae Sd197 AraC family transcriptional regulator YP_403391.1 1625225 R 300267 CDS YP_403393.1 82777044 3796197 complement(1627486..1627788) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1627788 3796197 SDY_1789 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403393.1 1627486 R 300267 CDS YP_403394.1 82777045 3796199 1629127..1630416 1 NC_007606.1 flavoprotein; probably electron transport; Code: C; COG: COG0644; hypothetical protein 1630416 ydiS 3796199 ydiS Shigella dysenteriae Sd197 hypothetical protein YP_403394.1 1629127 D 300267 CDS YP_403395.1 82777046 3796200 1630413..1630706 1 NC_007606.1 Code: C; COG: COG2440; hypothetical protein 1630706 ydiT 3796200 ydiT Shigella dysenteriae Sd197 hypothetical protein YP_403395.1 1630413 D 300267 CDS YP_403396.1 82777047 3796202 complement(1632467..1634845) 1 NC_007606.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1634845 ppsA 3796202 ppsA Shigella dysenteriae Sd197 phosphoenolpyruvate synthase YP_403396.1 1632467 R 300267 CDS YP_403397.1 82777048 3796203 1635073..1635438 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1635438 3796203 SDY_1795 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_403397.1 1635073 D 300267 CDS YP_403399.1 82777050 3796205 1636515..1637348 1 NC_007606.1 Code: S; COG: COG1806; hypothetical protein 1637348 ydiA 3796205 ydiA Shigella dysenteriae Sd197 hypothetical protein YP_403399.1 1636515 D 300267 CDS YP_403400.1 82777051 3796206 1637505..1638551 1 NC_007606.1 DAHP synthetase, tryptophan repressible; tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1638551 aroH 3796206 aroH Shigella dysenteriae Sd197 phospho-2-dehydro-3-deoxyheptonate aldolase YP_403400.1 1637505 D 300267 CDS YP_403401.1 82777052 3796207 1638683..1638874 1 NC_007606.1 Code: P; COG: COG4256; hypothetical protein 1638874 ydiE 3796207 ydiE Shigella dysenteriae Sd197 hypothetical protein YP_403401.1 1638683 D 300267 CDS YP_403404.1 82777055 3795985 complement(1640375..1641088) 1 NC_007606.1 Code: T; COG: COG2200; hypothetical protein 1641088 3795985 SDY_1802 Shigella dysenteriae Sd197 hypothetical protein YP_403404.1 1640375 R 300267 CDS YP_403405.1 82777056 3795986 complement(1641335..1641799) 1 NC_007606.1 Code: M; COG: COG0791; lipoprotein 1641799 nlpC 3795986 nlpC Shigella dysenteriae Sd197 lipoprotein YP_403405.1 1641335 R 300267 CDS YP_403406.1 82777057 3795987 complement(1641877..1642626) 1 NC_007606.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1642626 btuD 3795987 btuD Shigella dysenteriae Sd197 vitamin B12-transporter ATPase YP_403406.1 1641877 R 300267 CDS YP_403407.1 82777058 3795988 complement(1642626..1643177) 1 NC_007606.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 1643177 btuE 3795988 btuE Shigella dysenteriae Sd197 glutathione peroxidase YP_403407.1 1642626 R 300267 CDS YP_403408.1 82777059 3795989 complement(1643240..1644220) 1 NC_007606.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1644220 btuC 3795989 btuC Shigella dysenteriae Sd197 vtamin B12-transporter permease YP_403408.1 1643240 R 300267 CDS YP_403409.1 82777060 3795990 complement(1644321..1644620) 1 NC_007606.1 IHF; site-specific recombination; ''This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control''; integration host factor subunit alpha 1644620 ihfA 3795990 ihfA Shigella dysenteriae Sd197 integration host factor subunit alpha YP_403409.1 1644321 R 300267 CDS YP_403410.1 82777061 3795991 complement(1644625..1647012) 1 NC_007606.1 ''catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily''; phenylalanyl-tRNA synthetase subunit beta 1647012 pheT 3795991 pheT Shigella dysenteriae Sd197 phenylalanyl-tRNA synthetase subunit beta YP_403410.1 1644625 R 300267 CDS YP_403411.1 82777062 3795992 complement(1647027..1648010) 1 NC_007606.1 ''catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily''; phenylalanyl-tRNA synthetase subunit alpha 1648010 pheS 3795992 pheS Shigella dysenteriae Sd197 phenylalanyl-tRNA synthetase subunit alpha YP_403411.1 1647027 R 300267 CDS YP_403413.1 82777064 3795994 complement(1648460..1648816) 1 NC_007606.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1648816 rplT 3795994 rplT Shigella dysenteriae Sd197 50S ribosomal protein L20 YP_403413.1 1648460 R 300267 CDS YP_403414.1 82777065 3795995 complement(1648869..1649066) 1 NC_007606.1 Code: J; COG: COG0291; 50S ribosomal protein L35 1649066 rpmI 3795995 rpmI Shigella dysenteriae Sd197 50S ribosomal protein L35 YP_403414.1 1648869 R 300267 CDS YP_403415.2 578793206 3795996 complement(1649160..1649702) 1 NC_007606.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1649702 infC 3795996 infC Shigella dysenteriae Sd197 translation initiation factor IF-3 YP_403415.2 1649160 R 300267 CDS YP_403416.1 82777067 3795997 complement(1649706..1651634) 1 NC_007606.1 ''catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; threonyl-tRNA synthetase 1651634 thrS 3795997 thrS Shigella dysenteriae Sd197 threonyl-tRNA synthetase YP_403416.1 1649706 R 300267 CDS YP_009000742.1 578793207 18263056 1652079..1652351 1 NC_007606.1 insertion element iso-IS1N protein InsA 1652351 18263056 SDY_4672 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000742.1 1652079 D 300267 CDS YP_403417.1 82777068 3795998 1652378..1652773 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1652773 3795998 SDY_1815 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403417.1 1652378 D 300267 CDS YP_403418.1 82777069 3795999 1652940..1653869 1 NC_007606.1 suppressor of pfkA; Code: G; COG: COG1105; 6-phosphofructokinase 1653869 pfkB 3795999 pfkB Shigella dysenteriae Sd197 6-phosphofructokinase YP_403418.1 1652940 D 300267 CDS YP_403419.1 82777070 3796000 1653970..1654260 1 NC_007606.1 hypothetical protein 1654260 3796000 SDY_1817 Shigella dysenteriae Sd197 hypothetical protein YP_403419.1 1653970 D 300267 CDS YP_403420.1 82777071 3796001 1654366..1655226 1 NC_007606.1 Code: G; COG: COG3001; hypothetical protein 1655226 3796001 SDY_1818 Shigella dysenteriae Sd197 hypothetical protein YP_403420.1 1654366 D 300267 CDS YP_403421.1 82777072 3795691 complement(1655267..1655803) 1 NC_007606.1 hypothetical protein 1655803 3795691 SDY_1819 Shigella dysenteriae Sd197 hypothetical protein YP_403421.1 1655267 R 300267 CDS YP_403422.1 82777073 3795692 1655950..1656618 1 NC_007606.1 ''YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate''; 2-deoxyglucose-6-phosphatase 1656618 yniC 3795692 yniC Shigella dysenteriae Sd197 2-deoxyglucose-6-phosphatase YP_403422.1 1655950 D 300267 CDS YP_403423.2 161950108 3795693 1656782..1657372 1 NC_007606.1 Code: R; COG: COG1988; hypothetical protein 1657372 3795693 SDY_1821 Shigella dysenteriae Sd197 hypothetical protein YP_403423.2 1656782 D 300267 CDS YP_403424.1 82777075 3795694 complement(1657435..1657812) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1657812 insB 3795694 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403424.1 1657435 R 300267 CDS YP_403425.1 82777076 3795695 complement(1657857..1658132) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1658132 insA 3795695 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403425.1 1657857 R 300267 CDS YP_403426.1 82777077 3795696 1658219..1658935 1 NC_007606.1 RstB sensor; response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1658935 rstA 3795696 rstA Shigella dysenteriae Sd197 DNA-binding transcriptional regulator RstA YP_403426.1 1658219 D 300267 CDS YP_403427.1 82777078 3795697 1658939..1660240 1 NC_007606.1 RstA regulator; Code: T; COG: COG0642; sensor protein RstB 1660240 rstB 3795697 rstB Shigella dysenteriae Sd197 sensor protein RstB YP_403427.1 1658939 D 300267 CDS YP_403428.1 82777079 3795698 1660316..1661245 1 NC_007606.1 inhibition of replication at Ter sites; binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1661245 tus 3795698 tus Shigella dysenteriae Sd197 DNA replication terminus site-binding protein YP_403428.1 1660316 D 300267 CDS YP_403429.1 82777080 3795699 complement(1661242..1662645) 1 NC_007606.1 fumarate hydratase Class II; isozyme; class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1662645 fumC 3795699 fumC Shigella dysenteriae Sd197 fumarate hydratase YP_403429.1 1661242 R 300267 CDS YP_403430.1 82777081 3795700 complement(1662787..1664433) 1 NC_007606.1 fumarate hydratase Class I; aerobic isozyme; Code: C; COG: COG1951; fumarase A 1664433 fumA 3795700 fumA Shigella dysenteriae Sd197 fumarase A YP_403430.1 1662787 R 300267 CDS YP_403431.1 82777082 3795701 1664632..1665807 1 NC_007606.1 Code: G; COG: COG1482; mannose-6-phosphate isomerase 1665807 manA 3795701 manA Shigella dysenteriae Sd197 mannose-6-phosphate isomerase YP_403431.1 1664632 D 300267 CDS YP_403432.1 82777083 3795702 1665908..1667416 1 NC_007606.1 Code: S; COG: COG5339; hypothetical protein 1667416 ydgA 3795702 ydgA Shigella dysenteriae Sd197 hypothetical protein YP_403432.1 1665908 D 300267 CDS YP_009000743.1 578793208 18263057 1668648..1668920 1 NC_007606.1 insertion element iso-IS1N protein InsA 1668920 18263057 SDY_4673 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000743.1 1668648 D 300267 CDS YP_403433.1 82777084 3795704 1668947..1669342 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1669342 3795704 SDY_1832 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403433.1 1668947 D 300267 CDS YP_403437.1 82777088 3795709 complement(1673679..1674269) 1 NC_007606.1 Code: K; COG: COG1309; DNA-binding transcriptional repressor UidR 1674269 uidR 3795709 uidR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor UidR YP_403437.1 1673679 R 300267 CDS YP_403438.1 82777089 3795710 complement(1674498..1675265) 1 NC_007606.1 dehydroxylation of bile acids; Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1675265 hdhA 3795710 hdhA Shigella dysenteriae Sd197 7-alpha-hydroxysteroid dehydrogenase YP_403438.1 1674498 R 300267 CDS YP_403441.1 82777092 3795868 complement(1676800..1677828) 1 NC_007606.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1677828 malI 3795868 malI Shigella dysenteriae Sd197 DNA-binding transcriptional repressor MalI YP_403441.1 1676800 R 300267 CDS YP_403442.1 82777093 3795869 1678003..1679403 1 NC_007606.1 Code: G; COG: COG1263; PTS system maltose and glucose-specific transporter subunit IIABC 1679403 malX 3795869 malX Shigella dysenteriae Sd197 PTS system maltose and glucose-specific transporter subunit IIABC YP_403442.1 1678003 D 300267 CDS YP_403443.1 82777094 3795870 complement(1679378..1679773) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1679773 3795870 SDY_1843 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403443.1 1679378 R 300267 CDS YP_009000744.1 578793209 18263058 complement(1679800..1680054) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1680054 18263058 SDY_4674 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000744.1 1679800 R 300267 CDS YP_403445.1 82777096 3795872 1680362..1681534 1 NC_007606.1 enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase; Code: E; COG: COG1168; bifunctional beta-cystathionase/maltose operon regulator MalY 1681534 malY 3795872 malY Shigella dysenteriae Sd197 bifunctional beta-cystathionase/maltose operon regulator MalY YP_403445.1 1680362 D 300267 CDS YP_403446.1 82777097 3795873 1681638..1682639 1 NC_007606.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1682639 add 3795873 add Shigella dysenteriae Sd197 adenosine deaminase YP_403446.1 1681638 D 300267 CDS YP_403447.2 161950107 3795874 complement(1682675..1683715) 1 NC_007606.1 Code: R; COG: COG0673; oxidoreductase 1683715 3795874 SDY_1847 Shigella dysenteriae Sd197 oxidoreductase YP_403447.2 1682675 R 300267 CDS YP_403448.1 82777099 3795875 1684362..1684577 1 NC_007606.1 ''YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes''; oriC-binding nucleoid-associated protein 1684577 3795875 SDY_1848 Shigella dysenteriae Sd197 oriC-binding nucleoid-associated protein YP_403448.1 1684362 D 300267 CDS YP_403450.1 82777101 3795877 1685172..1685753 1 NC_007606.1 Code: C; COG: COG4657; Na(+)-translocating NADH-quinone reductase subunit E 1685753 3795877 SDY_1850 Shigella dysenteriae Sd197 Na(+)-translocating NADH-quinone reductase subunit E YP_403450.1 1685172 D 300267 CDS YP_403451.1 82777102 3795878 1685753..1686331 1 NC_007606.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1686331 3795878 SDY_1851 Shigella dysenteriae Sd197 electron transport complex protein RnfB YP_403451.1 1685753 D 300267 CDS YP_403452.1 82777103 3795879 1686324..1688642 1 NC_007606.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1688642 3795879 SDY_1852 Shigella dysenteriae Sd197 electron transport complex protein RnfC YP_403452.1 1686324 D 300267 CDS YP_403453.1 82777104 3795880 1688643..1689701 1 NC_007606.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1689701 rnfD 3795880 rnfD Shigella dysenteriae Sd197 electron transport complex protein RnfD YP_403453.1 1688643 D 300267 CDS YP_403454.1 82777105 3795881 1689705..1690325 1 NC_007606.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1690325 3795881 SDY_1854 Shigella dysenteriae Sd197 electron transport complex protein RnfG YP_403454.1 1689705 D 300267 CDS YP_403455.1 82777106 3795882 1690329..1691024 1 NC_007606.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 1691024 ydgQ 3795882 ydgQ Shigella dysenteriae Sd197 electron transport complex protein RsxE YP_403455.1 1690329 D 300267 CDS YP_403456.1 82777107 3795883 1691024..1691659 1 NC_007606.1 specific for apurinic and/or apyrimidinic sites; ''DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines''; endonuclease III 1691659 nth 3795883 nth Shigella dysenteriae Sd197 endonuclease III YP_403456.1 1691024 D 300267 CDS YP_403457.1 82777108 3795884 1692270..1693772 1 NC_007606.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1693772 tppB 3795884 tppB Shigella dysenteriae Sd197 tripeptide transporter permease YP_403457.1 1692270 D 300267 CDS YP_403458.1 82777109 3795769 1693878..1694483 1 NC_007606.1 Code: O; COG: COG0625; glutathionine S-transferase 1694483 gst 3795769 gst Shigella dysenteriae Sd197 glutathionine S-transferase YP_403458.1 1693878 D 300267 CDS YP_403459.1 82777110 3795770 complement(1694527..1695390) 1 NC_007606.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1695390 pdxY 3795770 pdxY Shigella dysenteriae Sd197 pyridoxamine kinase YP_403459.1 1694527 R 300267 CDS YP_403460.1 82777111 3795771 complement(1695449..1696723) 1 NC_007606.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1696723 tyrS 3795771 tyrS Shigella dysenteriae Sd197 tyrosyl-tRNA synthetase YP_403460.1 1695449 R 300267 CDS YP_403461.1 82777112 3795772 complement(1696852..1697508) 1 NC_007606.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1697508 pdxH 3795772 pdxH Shigella dysenteriae Sd197 pyridoxamine 5'-phosphate oxidase YP_403461.1 1696852 R 300267 CDS YP_403462.2 578793210 3795773 complement(1697567..1697896) 1 NC_007606.1 Code: R; COG: COG3895; hypothetical protein 1697896 ydhA 3795773 ydhA Shigella dysenteriae Sd197 hypothetical protein YP_403462.2 1697567 R 300267 CDS YP_403463.1 82777114 3795774 complement(1697994..1699103) 1 NC_007606.1 ''catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling''; anhydro-N-acetylmuramic acid kinase 1699103 anmK 3795774 anmK Shigella dysenteriae Sd197 anhydro-N-acetylmuramic acid kinase YP_403463.1 1697994 R 300267 CDS YP_403464.1 82777115 3795775 1699377..1699844 1 NC_007606.1 Code: M; COG: COG3133; outer membrane protein 1699844 slyB 3795775 slyB Shigella dysenteriae Sd197 outer membrane protein YP_403464.1 1699377 D 300267 CDS YP_403465.2 161950106 3795776 complement(1699891..1700325) 1 NC_007606.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1700325 slyA 3795776 slyA Shigella dysenteriae Sd197 transcriptional regulator SlyA YP_403465.2 1699891 R 300267 CDS YP_403466.1 82777117 3795777 1700526..1700762 1 NC_007606.1 hypothetical protein 1700762 3795777 SDY_1866 Shigella dysenteriae Sd197 hypothetical protein YP_403466.1 1700526 D 300267 CDS YP_403467.1 82777118 3795778 1700723..1701622 1 NC_007606.1 Code: V; COG: COG1566; hypothetical protein 1701622 3795778 SDY_1867 Shigella dysenteriae Sd197 hypothetical protein YP_403467.1 1700723 D 300267 CDS YP_403470.1 82777121 3795781 complement(1703649..1704170) 1 NC_007606.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1704170 sodC 3795781 sodC Shigella dysenteriae Sd197 superoxide dismutase YP_403470.1 1703649 R 300267 CDS YP_403471.1 82777122 3795782 complement(1704251..1705147) 1 NC_007606.1 Code: R; COG: COG4989; hypothetical protein 1705147 3795782 SDY_1871 Shigella dysenteriae Sd197 hypothetical protein YP_403471.1 1704251 R 300267 CDS YP_403472.1 82777124 3795784 complement(1705196..1705573) 1 NC_007606.1 Code: R; COG: COG3313; hypothetical protein 1705573 3795784 SDY_1873 Shigella dysenteriae Sd197 hypothetical protein YP_403472.1 1705196 R 300267 CDS YP_403473.1 82777123 3795783 1705538..1706137 1 NC_007606.1 Code: K; COG: COG1309; hypothetical protein 1706137 3795783 SDY_1872 Shigella dysenteriae Sd197 hypothetical protein YP_403473.1 1705538 D 300267 CDS YP_403474.1 82777125 3795785 complement(1706252..1706647) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1706647 3795785 SDY_1874 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403474.1 1706252 R 300267 CDS YP_009000745.1 578793211 18263059 complement(1706674..1706946) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1706946 18263059 SDY_4675 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000745.1 1706674 R 300267 CDS YP_403477.1 82777128 3795788 1708126..1708533 1 NC_007606.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1708533 gloA 3795788 gloA Shigella dysenteriae Sd197 glyoxalase I YP_403477.1 1708126 D 300267 CDS YP_403478.1 82777129 3798217 1708636..1709283 1 NC_007606.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1709283 rnt 3798217 rnt Shigella dysenteriae Sd197 ribonuclease T YP_403478.1 1708636 D 300267 CDS YP_403479.1 82777130 3798219 complement(1714043..1714390) 1 NC_007606.1 Code: O; COG: COG0278; hypothetical protein 1714390 ydhD 3798219 ydhD Shigella dysenteriae Sd197 hypothetical protein YP_403479.1 1714043 R 300267 CDS YP_403480.1 82777131 3798220 1714725..1715552 1 NC_007606.1 Code: M; COG: COG0791; lipoprotein 1715552 ydhO 3798220 ydhO Shigella dysenteriae Sd197 lipoprotein YP_403480.1 1714725 D 300267 CDS YP_403481.1 82777132 3798221 1715680..1716261 1 NC_007606.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1716261 sodB 3798221 sodB Shigella dysenteriae Sd197 superoxide dismutase YP_403481.1 1715680 D 300267 CDS YP_403482.1 82777133 3798222 complement(1716407..1717576) 1 NC_007606.1 Code: G; COG: COG2814; transport protein 1717576 3798222 SDY_1883 Shigella dysenteriae Sd197 transport protein YP_403482.1 1716407 R 300267 CDS YP_403483.1 82777134 3798223 1718130..1719155 1 NC_007606.1 transcriptional repressor for pur regulon, glyA, glnB, prsA, speA; ''binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers''; DNA-binding transcriptional repressor PurR 1719155 purR 3798223 purR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor PurR YP_403483.1 1718130 D 300267 CDS YP_403484.1 82777135 3798224 complement(1719152..1720084) 1 NC_007606.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 1720084 ydhB 3798224 ydhB Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YP_403484.1 1719152 R 300267 CDS YP_403485.1 82777136 3798225 1720197..1721408 1 NC_007606.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1721408 ydhC 3798225 ydhC Shigella dysenteriae Sd197 inner membrane transport protein YdhC YP_403485.1 1720197 D 300267 CDS YP_403486.1 82777137 3798226 1721699..1722847 1 NC_007606.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1722847 cfa 3798226 cfa Shigella dysenteriae Sd197 cyclopropane-fatty-acyl-phospholipid synthase YP_403486.1 1721699 D 300267 CDS YP_403487.1 82777138 3798227 complement(1722887..1723528) 1 NC_007606.1 ''catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine''; riboflavin synthase subunit alpha 1723528 ribE 3798227 ribE Shigella dysenteriae Sd197 riboflavin synthase subunit alpha YP_403487.1 1722887 R 300267 CDS YP_009000746.1 578793212 18263060 1723679..1723951 1 NC_007606.1 insertion element iso-IS1N protein InsA 1723951 18263060 SDY_4676 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000746.1 1723679 D 300267 CDS YP_403488.1 82777139 3798228 1723978..1724373 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1724373 3798228 SDY_1889 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403488.1 1723978 D 300267 CDS YP_403489.1 82777140 3798229 1724517..1725890 1 NC_007606.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1725890 ydhE 3798229 ydhE Shigella dysenteriae Sd197 multidrug efflux protein YP_403489.1 1724517 D 300267 CDS YP_403490.1 82777141 3798230 complement(1725931..1727187) 1 NC_007606.1 Code: MU; COG: COG3468; hypothetical protein 1727187 3798230 SDY_1891 Shigella dysenteriae Sd197 hypothetical protein YP_403490.1 1725931 R 300267 CDS YP_403492.1 82777143 3798311 complement(1728805..1729107) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1729107 3798311 SDY_1895 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403492.1 1728805 R 300267 CDS YP_403494.1 82777145 3798313 complement(1730729..1731541) 1 NC_007606.1 hypothetical protein 1731541 3798313 SDY_1897 Shigella dysenteriae Sd197 hypothetical protein YP_403494.1 1730729 R 300267 CDS YP_403495.1 82777146 3798314 complement(1731545..1732330) 1 NC_007606.1 Code: C; COG: COG4117; hypothetical protein 1732330 ydhU 3798314 ydhU Shigella dysenteriae Sd197 hypothetical protein YP_403495.1 1731545 R 300267 CDS YP_403496.1 82777147 3798315 complement(1732327..1733046) 1 NC_007606.1 Code: C; COG: COG0437; oxidoreductase Fe-S subunit 1733046 3798315 SDY_1899 Shigella dysenteriae Sd197 oxidoreductase Fe-S subunit YP_403496.1 1732327 R 300267 CDS YP_403497.1 82777148 3798316 complement(1733059..1733706) 1 NC_007606.1 hypothetical protein 1733706 3798316 SDY_1900 Shigella dysenteriae Sd197 hypothetical protein YP_403497.1 1733059 R 300267 CDS YP_403498.1 82777149 3798317 1733875..1734177 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1734177 3798317 SDY_1901 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403498.1 1733875 D 300267 CDS YP_403501.1 82777152 3798320 complement(1735129..1735338) 1 NC_007606.1 hypothetical protein 1735338 3798320 SDY_1904 Shigella dysenteriae Sd197 hypothetical protein YP_403501.1 1735129 R 300267 CDS YP_403502.1 82777153 3798321 1735895..1737307 1 NC_007606.1 formerly F; catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1737307 pykF 3798321 pykF Shigella dysenteriae Sd197 pyruvate kinase YP_403502.1 1735895 D 300267 CDS YP_403503.1 82777154 3798322 1737495..1737770 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1737770 insA 3798322 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403503.1 1737495 D 300267 CDS YP_403505.1 82777156 3798324 1738394..1738630 1 NC_007606.1 Code: M; COG: COG4238; murein lipoprotein 1738630 lpp 3798324 lpp Shigella dysenteriae Sd197 murein lipoprotein YP_403505.1 1738394 D 300267 CDS YP_403506.1 82777157 3798325 complement(1738693..1739697) 1 NC_007606.1 Code: S; COG: COG1376; hypothetical protein 1739697 ynhG 3798325 ynhG Shigella dysenteriae Sd197 hypothetical protein YP_403506.1 1738693 R 300267 CDS YP_403507.1 82777158 3798326 complement(1739846..1740262) 1 NC_007606.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1740262 ynhA 3798326 ynhA Shigella dysenteriae Sd197 cysteine desufuration protein SufE YP_403507.1 1739846 R 300267 CDS YP_403509.1 82777160 3798328 complement(1741492..1742763) 1 NC_007606.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase 1742763 ynhC 3798328 ynhC Shigella dysenteriae Sd197 cysteine desulfurase YP_403509.1 1741492 R 300267 CDS YP_403510.1 82777161 3798329 complement(1742738..1743484) 1 NC_007606.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 1743484 sufC 3798329 sufC Shigella dysenteriae Sd197 cysteine desulfurase YP_403510.1 1742738 R 300267 CDS YP_403512.1 82777163 3796443 complement(1744550..1745287) 1 NC_007606.1 phage Mu Mom-like protein 1745287 3796443 SDY_1915 Shigella dysenteriae Sd197 phage Mu Mom-like protein YP_403512.1 1744550 R 300267 CDS YP_403513.1 82777164 3796444 complement(1745479..1746072) 1 NC_007606.1 Code: L; COG: COG1961; DNA-invertase 1746072 3796444 SDY_1916 Shigella dysenteriae Sd197 DNA-invertase YP_403513.1 1745479 R 300267 CDS YP_403514.1 82777165 3796445 1746264..1746758 1 NC_007606.1 hypothetical protein 1746758 3796445 SDY_1917 Shigella dysenteriae Sd197 hypothetical protein YP_403514.1 1746264 D 300267 CDS YP_403515.1 82777166 3796446 complement(1746783..1747631) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1747631 3796446 SDY_1918 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_403515.1 1746783 R 300267 CDS YP_403516.1 82777167 3796447 complement(1749620..1750015) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1750015 3796447 SDY_1919 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403516.1 1749620 R 300267 CDS YP_009000747.1 578793213 18263061 complement(1750042..1750314) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1750314 18263061 SDY_4677 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000747.1 1750042 R 300267 CDS YP_403517.1 82777168 3796448 1750428..1750730 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1750730 3796448 SDY_1920 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403517.1 1750428 D 300267 CDS YP_403519.1 82777170 3796450 complement(1751625..1752287) 1 NC_007606.1 Fels-1 prophage DNA or RNA helicases of superfamily II; hypothetical protein 1752287 3796450 SDY_1922 Shigella dysenteriae Sd197 hypothetical protein YP_403519.1 1751625 R 300267 CDS YP_403520.1 82777171 3796451 complement(1752281..1752652) 1 NC_007606.1 hypothetical protein 1752652 3796451 SDY_1923 Shigella dysenteriae Sd197 hypothetical protein YP_403520.1 1752281 R 300267 CDS YP_403521.1 82777172 3796452 complement(1753199..1753402) 1 NC_007606.1 hypothetical protein 1753402 3796452 SDY_1924 Shigella dysenteriae Sd197 hypothetical protein YP_403521.1 1753199 R 300267 CDS YP_403522.1 82777173 3796453 1753498..1754211 1 NC_007606.1 Code: KT; COG: COG1974; repressor protein CI 1754211 3796453 SDY_1925 Shigella dysenteriae Sd197 repressor protein CI YP_403522.1 1753498 D 300267 CDS YP_403523.1 82777174 3796454 1754305..1755774 1 NC_007606.1 adenine-specific; site-specific DNA-methyltransferase 1755774 3796454 SDY_1926 Shigella dysenteriae Sd197 site-specific DNA-methyltransferase YP_403523.1 1754305 D 300267 CDS YP_403524.1 82777175 3796455 1755771..1756724 1 NC_007606.1 type II site-specific deoxyribonuclease 1756724 3796455 SDY_1927 Shigella dysenteriae Sd197 type II site-specific deoxyribonuclease YP_403524.1 1755771 D 300267 CDS YP_403525.1 82777176 3796456 1757618..1758034 1 NC_007606.1 hypothetical protein 1758034 3796456 SDY_1928 Shigella dysenteriae Sd197 hypothetical protein YP_403525.1 1757618 D 300267 CDS YP_403526.1 82777177 3796457 1758031..1758264 1 NC_007606.1 hypothetical protein 1758264 3796457 SDY_1929 Shigella dysenteriae Sd197 hypothetical protein YP_403526.1 1758031 D 300267 CDS YP_403529.1 82777180 3796460 complement(1759284..1759586) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1759586 3796460 SDY_1932 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_403529.1 1759284 R 300267 CDS YP_403530.1 82777181 3796461 1759633..1759800 1 NC_007606.1 prophage Kil protein 1759800 3796461 SDY_1933 Shigella dysenteriae Sd197 prophage Kil protein YP_403530.1 1759633 D 300267 CDS YP_403531.1 82777182 3798689 1759856..1760131 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1760131 insA 3798689 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403531.1 1759856 D 300267 CDS YP_009000748.1 578793214 18263062 1760176..1760553 1 NC_007606.1 insertion sequence element IS1 transposase 1760553 18263062 SDY_1934a Shigella dysenteriae Sd197 insertion sequence element IS1 transposase YP_009000748.1 1760176 D 300267 CDS YP_403532.1 82777183 3798691 complement(1761846..1762160) 1 NC_007606.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1762160 pspE 3798691 pspE Shigella dysenteriae Sd197 thiosulfate:cyanide sulfurtransferase YP_403532.1 1761846 R 300267 CDS YP_403533.1 82777184 3798692 complement(1762235..1762456) 1 NC_007606.1 peripheral inner membrane phage-shock protein 1762456 pspD 3798692 pspD Shigella dysenteriae Sd197 peripheral inner membrane phage-shock protein YP_403533.1 1762235 R 300267 CDS YP_403534.1 82777185 3798693 complement(1762465..1762824) 1 NC_007606.1 activates phage shock-protein expression; ''with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock''; DNA-binding transcriptional activator PspC 1762824 pspC 3798693 pspC Shigella dysenteriae Sd197 DNA-binding transcriptional activator PspC YP_403534.1 1762465 R 300267 CDS YP_403535.1 82777186 3798694 complement(1762824..1763048) 1 NC_007606.1 ''acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding''; phage shock protein B 1763048 pspB 3798694 pspB Shigella dysenteriae Sd197 phage shock protein B YP_403535.1 1762824 R 300267 CDS YP_403536.1 82777187 3798695 complement(1763102..1763770) 1 NC_007606.1 inner membrane protein; involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1763770 pspA 3798695 pspA Shigella dysenteriae Sd197 phage shock protein PspA YP_403536.1 1763102 R 300267 CDS YP_403537.2 161950105 3798696 1763937..1764914 1 NC_007606.1 ''transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor''; phage shock protein operon transcriptional activator 1764914 pspF 3798696 pspF Shigella dysenteriae Sd197 phage shock protein operon transcriptional activator YP_403537.2 1763937 D 300267 CDS YP_403538.1 82777189 3798698 complement(1766347..1767627) 1 NC_007606.1 Code: E; COG: COG0665; oxidoreductase 1767627 ordL 3798698 ordL Shigella dysenteriae Sd197 oxidoreductase YP_403538.1 1766347 R 300267 CDS YP_403539.1 82777190 3798700 complement(1769266..1769823) 1 NC_007606.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1769823 ycjC 3798700 ycjC Shigella dysenteriae Sd197 DNA-binding transcriptional repressor PuuR YP_403539.1 1769266 R 300267 CDS YP_403541.1 82777192 3798704 complement(1773369..1773764) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1773764 3798704 SDY_1949 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403541.1 1773369 R 300267 CDS YP_009000749.1 578793215 18263063 complement(1773791..1774063) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1774063 18263063 SDY_4678 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000749.1 1773791 R 300267 CDS YP_403542.1 82777193 3798705 complement(1774286..1774498) 1 NC_007606.1 hypothetical protein 1774498 3798705 SDY_1950 Shigella dysenteriae Sd197 hypothetical protein YP_403542.1 1774286 R 300267 CDS YP_403543.1 82777194 3798706 complement(1774574..1775182) 1 NC_007606.1 Code: O; COG: COG0625; transferase 1775182 3798706 SDY_1951 Shigella dysenteriae Sd197 transferase YP_403543.1 1774574 R 300267 CDS YP_403544.1 82777195 3798707 1775398..1776948 1 NC_007606.1 Code: E; COG: COG1113; L-asparagine permease 1776948 ansP 3798707 ansP Shigella dysenteriae Sd197 L-asparagine permease YP_403544.1 1775398 D 300267 CDS YP_403545.1 82777196 3798708 complement(1777061..1778122) 1 NC_007606.1 Code: S; COG: COG3391; receptor 1778122 3798708 SDY_1953 Shigella dysenteriae Sd197 receptor YP_403545.1 1777061 R 300267 CDS YP_403546.2 161950104 3798080 1778364..1780067 1 NC_007606.1 Code: P; COG: COG1629; outer membrane receptor for iron transport 1780067 3798080 SDY_1954 Shigella dysenteriae Sd197 outer membrane receptor for iron transport YP_403546.2 1778364 D 300267 CDS YP_009000750.1 578793216 18263064 1780361..1780633 1 NC_007606.1 insertion element iso-IS1N protein InsA 1780633 18263064 SDY_4679 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000750.1 1780361 D 300267 CDS YP_403548.1 82777199 3798082 1780660..1781055 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1781055 3798082 SDY_1956 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403548.1 1780660 D 300267 CDS YP_403549.1 82777200 3798083 complement(1781276..1781713) 1 NC_007606.1 Code: K; COG: COG1802; hypothetical protein 1781713 3798083 SDY_1957 Shigella dysenteriae Sd197 hypothetical protein YP_403549.1 1781276 R 300267 CDS YP_403550.1 82777201 3798084 1781775..1782050 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1782050 insA 3798084 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403550.1 1781775 D 300267 CDS YP_403551.1 82777202 3798085 1782095..1782472 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1782472 insB 3798085 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403551.1 1782095 D 300267 CDS YP_403554.1 82777205 3798088 complement(1783914..1785464) 1 NC_007606.1 Code: R; COG: COG1253; transport protein 1785464 yoaE 3798088 yoaE Shigella dysenteriae Sd197 transport protein YP_403554.1 1783914 R 300267 CDS YP_403555.1 82777206 3798089 1785928..1786899 1 NC_007606.1 Code: G; COG: COG2893; PTS system mannose-specific transporter subunit IIAB 1786899 manX 3798089 manX Shigella dysenteriae Sd197 PTS system mannose-specific transporter subunit IIAB YP_403555.1 1785928 D 300267 CDS YP_403556.1 82777207 3798091 1787767..1788627 1 NC_007606.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1788627 manZ 3798091 manZ Shigella dysenteriae Sd197 PTS system mannose-specific transporter subunit IID YP_403556.1 1787767 D 300267 CDS YP_403557.1 82777208 3798092 1788682..1789140 1 NC_007606.1 Code: S; COG: COG4811; hypothetical protein 1789140 3798092 SDY_1966 Shigella dysenteriae Sd197 hypothetical protein YP_403557.1 1788682 D 300267 CDS YP_403558.1 82777209 3798093 1789515..1790135 1 NC_007606.1 membrane protein YebN; hypothetical protein 1790135 3798093 SDY_1967 Shigella dysenteriae Sd197 hypothetical protein YP_403558.1 1789515 D 300267 CDS YP_403559.1 82777210 3798094 complement(1790132..1790941) 1 NC_007606.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase 1790941 rrmA 3798094 rrmA Shigella dysenteriae Sd197 23S rRNA methyltransferase YP_403559.1 1790132 R 300267 CDS YP_403560.1 82777211 3798095 complement(1791107..1791316) 1 NC_007606.1 Code: K; COG: COG1278; cold shock-like protein CspC 1791316 cspC 3798095 cspC Shigella dysenteriae Sd197 cold shock-like protein CspC YP_403560.1 1791107 R 300267 CDS YP_403561.1 82777212 3798096 complement(1791329..1791472) 1 NC_007606.1 hypothetical protein 1791472 3798096 SDY_1970 Shigella dysenteriae Sd197 hypothetical protein YP_403561.1 1791329 R 300267 CDS YP_009000751.1 578793217 18263065 1792051..1792323 1 NC_007606.1 insertion element iso-IS1N protein InsA 1792323 18263065 SDY_4680 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000751.1 1792051 D 300267 CDS YP_403562.1 82777213 3798097 1792350..1792745 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1792745 3798097 SDY_1971 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403562.1 1792350 D 300267 CDS YP_403563.1 82777214 3798098 complement(1792762..1793049) 1 NC_007606.1 hypothetical protein 1793049 3798098 SDY_1972 Shigella dysenteriae Sd197 hypothetical protein YP_403563.1 1792762 R 300267 CDS YP_403564.1 82777215 3798822 complement(1793124..1793267) 1 NC_007606.1 hypothetical protein 1793267 3798822 SDY_1973 Shigella dysenteriae Sd197 hypothetical protein YP_403564.1 1793124 R 300267 CDS YP_403565.1 82777216 3798823 1793426..1793665 1 NC_007606.1 hypothetical protein 1793665 3798823 SDY_1974 Shigella dysenteriae Sd197 hypothetical protein YP_403565.1 1793426 D 300267 CDS YP_403566.1 82777217 3798824 complement(1793809..1794600) 1 NC_007606.1 Code: K; COG: COG1414; regulator 1794600 3798824 SDY_1975 Shigella dysenteriae Sd197 regulator YP_403566.1 1793809 R 300267 CDS YP_403567.1 82777218 3798825 1794666..1796048 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 1796048 3798825 SDY_1976 Shigella dysenteriae Sd197 transport protein YP_403567.1 1794666 D 300267 CDS YP_403568.1 82777219 3798826 complement(1796191..1797072) 1 NC_007606.1 integral membrane protein; metalloprotease; heat shock protein HtpX 1797072 htpX 3798826 htpX Shigella dysenteriae Sd197 heat shock protein HtpX YP_403568.1 1796191 R 300267 CDS YP_403569.1 82777220 3798827 complement(1797264..1799312) 1 NC_007606.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1799312 prc 3798827 prc Shigella dysenteriae Sd197 carboxy-terminal protease YP_403569.1 1797264 R 300267 CDS YP_403570.1 82777221 3798828 complement(1799332..1800030) 1 NC_007606.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 1800030 proQ 3798828 proQ Shigella dysenteriae Sd197 solute/DNA competence effector YP_403570.1 1799332 R 300267 CDS YP_403571.1 82777222 3798829 complement(1800127..1800678) 1 NC_007606.1 Code: T; COG: COG1956; hypothetical protein 1800678 3798829 SDY_1980 Shigella dysenteriae Sd197 hypothetical protein YP_403571.1 1800127 R 300267 CDS YP_403572.1 82777223 3798830 1800754..1801074 1 NC_007606.1 hypothetical protein 1801074 3798830 SDY_1981 Shigella dysenteriae Sd197 hypothetical protein YP_403572.1 1800754 D 300267 CDS YP_403573.1 82777224 3798831 1801111..1801611 1 NC_007606.1 hypothetical protein 1801611 3798831 SDY_1982 Shigella dysenteriae Sd197 hypothetical protein YP_403573.1 1801111 D 300267 CDS YP_009000752.1 578793218 18263066 1801651..1801923 1 NC_007606.1 insertion element iso-IS1N protein InsA 1801923 18263066 SDY_4681 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000752.1 1801651 D 300267 CDS YP_403574.1 82777225 3798832 1801950..1802345 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1802345 3798832 SDY_1983 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403574.1 1801950 D 300267 CDS YP_403575.1 82777226 3798833 1802375..1802812 1 NC_007606.1 hypothetical protein 1802812 3798833 SDY_1984 Shigella dysenteriae Sd197 hypothetical protein YP_403575.1 1802375 D 300267 CDS YP_403576.1 82777227 3798834 1802775..1805402 1 NC_007606.1 Code: R; COG: COG3008; hypothetical protein 1805402 3798834 SDY_1985 Shigella dysenteriae Sd197 hypothetical protein YP_403576.1 1802775 D 300267 CDS YP_403577.1 82777228 3798835 1805476..1806921 1 NC_007606.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1806921 yebU 3798835 yebU Shigella dysenteriae Sd197 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_403577.1 1805476 D 300267 CDS YP_403578.1 82777229 3798836 1807024..1807275 1 NC_007606.1 hypothetical protein 1807275 3798836 SDY_1987 Shigella dysenteriae Sd197 hypothetical protein YP_403578.1 1807024 D 300267 CDS YP_403579.2 578793219 3798837 1807380..1807571 1 NC_007606.1 hypothetical protein 1807571 3798837 SDY_1988 Shigella dysenteriae Sd197 hypothetical protein YP_403579.2 1807380 D 300267 CDS YP_403581.1 82777232 3798840 1808751..1809053 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 1809053 3798840 SDY_1991 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_403581.1 1808751 D 300267 CDS YP_403582.1 82777233 3798841 1809080..1809919 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 1809919 3798841 SDY_1992 Shigella dysenteriae Sd197 insertion sequence element IS911 integrase core domain-containing protein YP_403582.1 1809080 D 300267 CDS YP_403583.1 82777234 3797538 complement(1809934..1810203) 1 NC_007606.1 hypothetical protein 1810203 3797538 SDY_1993 Shigella dysenteriae Sd197 hypothetical protein YP_403583.1 1809934 R 300267 CDS YP_403584.1 82777235 3797543 1810827..1811042 1 NC_007606.1 hypothetical protein 1811042 ybcR 3797543 ybcR Shigella dysenteriae Sd197 hypothetical protein YP_403584.1 1810827 D 300267 CDS YP_403585.1 82777236 3797544 1811227..1811529 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1811529 3797544 SDY_1999 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403585.1 1811227 D 300267 CDS YP_403587.1 82777238 3797546 complement(1812689..1814404) 1 NC_007606.1 Code: S; COG: COG4886; invasion plasmid antigen 1814404 ipaH_4 3797546 ipaH_4 Shigella dysenteriae Sd197 invasion plasmid antigen YP_403587.1 1812689 R 300267 CDS YP_009000753.1 578793220 18263067 1814862..1815134 1 NC_007606.1 insertion element iso-IS1N protein InsA 1815134 18263067 SDY_4682 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000753.1 1814862 D 300267 CDS YP_403588.1 82777239 3797547 1815161..1815556 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1815556 3797547 SDY_2002 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403588.1 1815161 D 300267 CDS YP_403589.1 82777240 3797548 1816133..1817884 1 NC_007606.1 Code: S; COG: COG4886; invasion plasmid antigen 1817884 ipaH_5 3797548 ipaH_5 Shigella dysenteriae Sd197 invasion plasmid antigen YP_403589.1 1816133 D 300267 CDS YP_403592.1 82777243 3797551 complement(1819408..1819680) 1 NC_007606.1 hypothetical protein 1819680 3797551 SDY_2006 Shigella dysenteriae Sd197 hypothetical protein YP_403592.1 1819408 R 300267 CDS YP_403593.1 82777244 3797552 complement(1819681..1820076) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1820076 3797552 SDY_2007 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403593.1 1819681 R 300267 CDS YP_009000754.1 578793221 18263068 complement(1820103..1820375) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1820375 18263068 SDY_4683 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000754.1 1820103 R 300267 CDS YP_403594.1 82777245 3799904 1820489..1820791 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1820791 3799904 SDY_2008 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403594.1 1820489 D 300267 CDS YP_403597.1 82777248 3799907 1821904..1822899 1 NC_007606.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 1822899 ybhE 3799907 ybhE Shigella dysenteriae Sd197 6-phosphogluconolactonase YP_403597.1 1821904 D 300267 CDS YP_403598.1 82777249 3799908 complement(1822940..1823392) 1 NC_007606.1 hypothetical protein 1823392 3799908 SDY_2012 Shigella dysenteriae Sd197 hypothetical protein YP_403598.1 1822940 R 300267 CDS YP_403599.1 82777250 3799909 complement(1823444..1823839) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1823839 3799909 SDY_2013 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403599.1 1823444 R 300267 CDS YP_009000755.1 578793222 18263069 complement(1823866..1824138) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1824138 18263069 SDY_4684 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000755.1 1823866 R 300267 CDS YP_403601.1 82777252 3799911 1824467..1824790 1 NC_007606.1 hypothetical protein 1824790 ycgW 3799911 ycgW Shigella dysenteriae Sd197 hypothetical protein YP_403601.1 1824467 D 300267 CDS YP_403602.1 82777253 3799912 complement(1824893..1826143) 1 NC_007606.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1826143 icdA 3799912 icdA Shigella dysenteriae Sd197 isocitrate dehydrogenase YP_403602.1 1824893 R 300267 CDS YP_403603.1 82777254 3799913 1826345..1826968 1 NC_007606.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1826968 ymfC 3799913 ymfC Shigella dysenteriae Sd197 23S rRNA pseudouridine synthase E YP_403603.1 1826345 D 300267 CDS YP_403604.1 82777255 3799914 1826978..1827439 1 NC_007606.1 Code: LR; COG: COG0494; phosphohydrolase 1827439 3799914 SDY_2018 Shigella dysenteriae Sd197 phosphohydrolase YP_403604.1 1826978 D 300267 CDS YP_403605.2 161950103 3799915 1827493..1828599 1 NC_007606.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1828599 mnmA 3799915 mnmA Shigella dysenteriae Sd197 tRNA-specific 2-thiouridylase MnmA YP_403605.2 1827493 D 300267 CDS YP_403606.1 82777257 3799916 1828635..1829276 1 NC_007606.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1829276 ycfC 3799916 ycfC Shigella dysenteriae Sd197 hypothetical protein YP_403606.1 1828635 D 300267 CDS YP_403607.1 82777258 3799917 1829280..1830650 1 NC_007606.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1830650 purB 3799917 purB Shigella dysenteriae Sd197 adenylosuccinate lyase YP_403607.1 1829280 D 300267 CDS YP_403608.1 82777259 3799918 1830819..1831490 1 NC_007606.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1831490 phoP 3799918 phoP Shigella dysenteriae Sd197 DNA-binding transcriptional regulator PhoP YP_403608.1 1830819 D 300267 CDS YP_403609.1 82777260 3799919 1831490..1832950 1 NC_007606.1 Code: T; COG: COG0642; sensor protein PhoQ 1832950 phoQ 3799919 phoQ Shigella dysenteriae Sd197 sensor protein PhoQ YP_403609.1 1831490 D 300267 CDS YP_403610.1 82777261 3799920 1833017..1834147 1 NC_007606.1 Code: S; COG: COG2850; hypothetical protein 1834147 ycfD 3799920 ycfD Shigella dysenteriae Sd197 hypothetical protein YP_403610.1 1833017 D 300267 CDS YP_403611.1 82777262 3799921 complement(1834196..1835422) 1 NC_007606.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1835422 pepT 3799921 pepT Shigella dysenteriae Sd197 peptidase T YP_403611.1 1834196 R 300267 CDS YP_403612.1 82777263 3799922 1835672..1836808 1 NC_007606.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1836808 potA 3799922 potA Shigella dysenteriae Sd197 putrescine/spermidine ABC transporter ATPase YP_403612.1 1835672 D 300267 CDS YP_403613.1 82777264 3799768 1836822..1837649 1 NC_007606.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter permease 1837649 potB 3799768 potB Shigella dysenteriae Sd197 spermidine/putrescine ABC transporter permease YP_403613.1 1836822 D 300267 CDS YP_403614.1 82777265 3799769 1837646..1838440 1 NC_007606.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter permease 1838440 potC 3799769 potC Shigella dysenteriae Sd197 spermidine/putrescine ABC transporter permease YP_403614.1 1837646 D 300267 CDS YP_403615.1 82777266 3799770 1838437..1839483 1 NC_007606.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1839483 potD 3799770 potD Shigella dysenteriae Sd197 spermidine/putrescine ABC transporter substrate-binding protein YP_403615.1 1838437 D 300267 CDS YP_403616.1 82777267 3799771 complement(1839639..1840460) 1 NC_007606.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1840460 cobB 3799771 cobB Shigella dysenteriae Sd197 NAD-dependent deacetylase YP_403616.1 1839639 R 300267 CDS YP_403617.1 82777268 3799772 complement(1840476..1841387) 1 NC_007606.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1841387 ycfX 3799772 ycfX Shigella dysenteriae Sd197 N-acetyl-D-glucosamine kinase YP_403617.1 1840476 R 300267 CDS YP_403618.1 82777269 3799773 complement(1841416..1842660) 1 NC_007606.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1842660 ycfW 3799773 ycfW Shigella dysenteriae Sd197 outer membrane-specific lipoprotein transporter subunit LolE YP_403618.1 1841416 R 300267 CDS YP_403619.2 161950102 3799774 complement(1842660..1843361) 1 NC_007606.1 ''outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone''; lipoprotein ABC transporter ATP-binding subunit 1843361 lolD 3799774 lolD Shigella dysenteriae Sd197 lipoprotein ABC transporter ATP-binding subunit YP_403619.2 1842660 R 300267 CDS YP_403620.1 82777271 3799775 complement(1843354..1844553) 1 NC_007606.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1844553 ycfU 3799775 ycfU Shigella dysenteriae Sd197 outer membrane-specific lipoprotein transporter subunit LolC YP_403620.1 1843354 R 300267 CDS YP_403621.1 82777272 3799776 1844815..1845888 1 NC_007606.1 Code: S; COG: COG4763; hypothetical protein 1845888 ycfT 3799776 ycfT Shigella dysenteriae Sd197 hypothetical protein YP_403621.1 1844815 D 300267 CDS YP_403622.1 82777273 3799777 1846016..1849462 1 NC_007606.1 mutation frequency decline; Code: LK; COG: COG1197; transcription-repair coupling factor 1849462 mfd 3799777 mfd Shigella dysenteriae Sd197 transcription-repair coupling factor YP_403622.1 1846016 D 300267 CDS YP_403623.1 82777274 3799778 1849604..1850566 1 NC_007606.1 Code: S; COG: COG1376; hypothetical protein 1850566 ycfS 3799778 ycfS Shigella dysenteriae Sd197 hypothetical protein YP_403623.1 1849604 D 300267 CDS YP_403624.1 82777275 3799779 complement(1850649..1850906) 1 NC_007606.1 hypothetical protein 1850906 ycfR 3799779 ycfR Shigella dysenteriae Sd197 hypothetical protein YP_403624.1 1850649 R 300267 CDS YP_403625.1 82777276 3799780 1851069..1851779 1 NC_007606.1 Code: K; COG: COG1309; hypothetical protein 1851779 ycfQ 3799780 ycfQ Shigella dysenteriae Sd197 hypothetical protein YP_403625.1 1851069 D 300267 CDS YP_403626.1 82777277 3799781 complement(1851841..1852380) 1 NC_007606.1 Code: S; COG: COG3134; hypothetical protein 1852380 ycfJ 3799781 ycfJ Shigella dysenteriae Sd197 hypothetical protein YP_403626.1 1851841 R 300267 CDS YP_403627.1 82777278 3799782 complement(1852607..1853911) 1 NC_007606.1 Code: C; COG: COG1252; respiratory NADH dehydrogenase 1853911 ndh 3799782 ndh Shigella dysenteriae Sd197 respiratory NADH dehydrogenase YP_403627.1 1852607 R 300267 CDS YP_403628.2 161950101 3799783 complement(1854317..1854859) 1 NC_007606.1 Code: R; COG: COG3150; hypothetical protein 1854859 ycfP 3799783 ycfP Shigella dysenteriae Sd197 hypothetical protein YP_403628.2 1854317 R 300267 CDS YP_403629.1 82777280 3799784 complement(1854882..1855907) 1 NC_007606.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1855907 ycfO 3799784 ycfO Shigella dysenteriae Sd197 beta-hexosaminidase YP_403629.1 1854882 R 300267 CDS YP_403630.1 82777281 3799785 complement(1855918..1856742) 1 NC_007606.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1856742 thiK 3799785 thiK Shigella dysenteriae Sd197 thiamine kinase YP_403630.1 1855918 R 300267 CDS YP_403631.1 82777282 3799786 complement(1856723..1857364) 1 NC_007606.1 Code: R; COG: COG3417; hypothetical protein 1857364 ycfM 3799786 ycfM Shigella dysenteriae Sd197 hypothetical protein YP_403631.1 1856723 R 300267 CDS YP_403632.1 82777283 3799787 complement(1857378..1857755) 1 NC_007606.1 Code: R; COG: COG5633; hypothetical protein 1857755 ycfL 3799787 ycfL Shigella dysenteriae Sd197 hypothetical protein YP_403632.1 1857378 R 300267 CDS YP_403633.1 82777284 3799518 complement(1857758..1858117) 1 NC_007606.1 Code: FGR; COG: COG0537; purine nucleoside phosphoramidase 1858117 ycfF 3799518 ycfF Shigella dysenteriae Sd197 purine nucleoside phosphoramidase YP_403633.1 1857758 R 300267 CDS YP_403634.1 82777285 3799519 1858440..1860629 1 NC_007606.1 Code: P; COG: COG4773; ferric-rhodotorulic acid outer membrane transporter 1860629 fhuE 3799519 fhuE Shigella dysenteriae Sd197 ferric-rhodotorulic acid outer membrane transporter YP_403634.1 1858440 D 300267 CDS YP_403635.1 82777286 3799520 complement(1860689..1862122) 1 NC_007606.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1862122 ptsG 3799520 ptsG Shigella dysenteriae Sd197 PTS system glucose-specific transporter subunit IIBC YP_403635.1 1860689 R 300267 CDS YP_403636.1 82777287 3799521 complement(1862417..1863214) 1 NC_007606.1 Code: L; COG: COG0084; metallodependent hydrolase 1863214 ycfH 3799521 ycfH Shigella dysenteriae Sd197 metallodependent hydrolase YP_403636.1 1862417 R 300267 CDS YP_403637.1 82777288 3799522 complement(1863225..1864229) 1 NC_007606.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1864229 holB 3799522 holB Shigella dysenteriae Sd197 DNA polymerase III subunit delta' YP_403637.1 1863225 R 300267 CDS YP_403638.1 82777289 3799523 complement(1864226..1864867) 1 NC_007606.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1864867 tmk 3799523 tmk Shigella dysenteriae Sd197 thymidylate kinase YP_403638.1 1864226 R 300267 CDS YP_403639.1 82777290 3799524 complement(1864857..1865879) 1 NC_007606.1 Code: R; COG: COG1559; hypothetical protein 1865879 yceG 3799524 yceG Shigella dysenteriae Sd197 hypothetical protein YP_403639.1 1864857 R 300267 CDS YP_403640.1 82777291 3799525 complement(1865882..1866691) 1 NC_007606.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1866691 pabC 3799525 pabC Shigella dysenteriae Sd197 4-amino-4-deoxychorismate lyase YP_403640.1 1865882 R 300267 CDS YP_403641.1 82777292 3799526 complement(1866811..1868052) 1 NC_007606.1 ''FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''; 3-oxoacyl-ACP synthase 1868052 fabF 3799526 fabF Shigella dysenteriae Sd197 3-oxoacyl-ACP synthase YP_403641.1 1866811 R 300267 CDS YP_403642.1 82777293 3799527 complement(1868138..1868374) 1 NC_007606.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1868374 acpP 3799527 acpP Shigella dysenteriae Sd197 acyl carrier protein YP_403642.1 1868138 R 300267 CDS YP_403643.1 82777294 3799528 complement(1868585..1869319) 1 NC_007606.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1869319 fabG 3799528 fabG Shigella dysenteriae Sd197 3-ketoacyl-ACP reductase YP_403643.1 1868585 R 300267 CDS YP_403644.1 82777295 3799529 complement(1869332..1870261) 1 NC_007606.1 Code: I; COG: COG0331; malonyl CoA-ACP transacylase 1870261 fabD 3799529 fabD Shigella dysenteriae Sd197 malonyl CoA-ACP transacylase YP_403644.1 1869332 R 300267 CDS YP_403645.1 82777296 3799530 complement(1870277..1871230) 1 NC_007606.1 acetylCoA ACP transacylase; FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1871230 fabH 3799530 fabH Shigella dysenteriae Sd197 3-oxoacyl-ACP synthase YP_403645.1 1870277 R 300267 CDS YP_403646.2 161950100 3799531 complement(1871298..1872368) 1 NC_007606.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1872368 plsX 3799531 plsX Shigella dysenteriae Sd197 glycerol-3-phosphate acyltransferase PlsX YP_403646.2 1871298 R 300267 CDS YP_403647.1 82777298 3799532 complement(1872449..1872622) 1 NC_007606.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1872622 rpmF 3799532 rpmF Shigella dysenteriae Sd197 50S ribosomal protein L32 YP_403647.1 1872449 R 300267 CDS YP_403648.1 82777299 3799533 complement(1872674..1873195) 1 NC_007606.1 Code: R; COG: COG1399; hypothetical protein 1873195 yceD 3799533 yceD Shigella dysenteriae Sd197 hypothetical protein YP_403648.1 1872674 R 300267 CDS YP_403649.1 82777300 3799534 complement(1873768..1874163) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1874163 3799534 SDY_2063 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403649.1 1873768 R 300267 CDS YP_403651.1 82777302 3799536 complement(1874864..1875823) 1 NC_007606.1 ''catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA''; 23S rRNA pseudouridylate synthase C 1875823 yceC 3799536 yceC Shigella dysenteriae Sd197 23S rRNA pseudouridylate synthase C YP_403651.1 1874864 R 300267 CDS YP_403652.1 82777303 3799498 complement(1875941..1876315) 1 NC_007606.1 hypothetical protein 1876315 3799498 SDY_2066 Shigella dysenteriae Sd197 hypothetical protein YP_403652.1 1875941 R 300267 CDS YP_403653.1 82777304 3799499 1876396..1879581 1 NC_007606.1 membrane attachment, mRNA turnover, maturation 5S RNA; ''bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase''; ribonuclease E 1879581 rne 3799499 rne Shigella dysenteriae Sd197 ribonuclease E YP_403653.1 1876396 D 300267 CDS YP_403655.1 82777306 3799502 complement(1882427..1883368) 1 NC_007606.1 flagellar biosynthesis; Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1883368 flgJ 3799502 flgJ Shigella dysenteriae Sd197 flagellar rod assembly protein/muramidase FlgJ YP_403655.1 1882427 R 300267 CDS YP_403656.1 82777307 3799503 complement(1883368..1884465) 1 NC_007606.1 ''part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum''; flagellar basal body P-ring biosynthesis protein FlgA 1884465 flgI 3799503 flgI Shigella dysenteriae Sd197 flagellar basal body P-ring biosynthesis protein FlgA YP_403656.1 1883368 R 300267 CDS YP_403657.1 82777308 3799504 complement(1884477..1885175) 1 NC_007606.1 flagellar biosynthesis; lipopolysaccharide layer; ''part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod''; flagellar basal body L-ring protein 1885175 flgH 3799504 flgH Shigella dysenteriae Sd197 flagellar basal body L-ring protein YP_403657.1 1884477 R 300267 CDS YP_403658.1 82777309 3799507 complement(1886919..1888127) 1 NC_007606.1 flagellar biosynthesis; the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1888127 flgE 3799507 flgE Shigella dysenteriae Sd197 flagellar hook protein FlgE YP_403658.1 1886919 R 300267 CDS YP_403659.1 82777310 3799508 complement(1888152..1888847) 1 NC_007606.1 flagellar biosynthesis; ''acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production''; flagellar basal body rod modification protein 1888847 flgD 3799508 flgD Shigella dysenteriae Sd197 flagellar basal body rod modification protein YP_403659.1 1888152 R 300267 CDS YP_403660.1 82777311 3799509 complement(1888859..1889263) 1 NC_007606.1 flagellar biosynthesis; with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1889263 flgC 3799509 flgC Shigella dysenteriae Sd197 flagellar basal body rod protein FlgC YP_403660.1 1888859 R 300267 CDS YP_403661.1 82777312 3799510 complement(1889267..1889683) 1 NC_007606.1 flagellar biosynthesis; with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1889683 flgB 3799510 flgB Shigella dysenteriae Sd197 flagellar basal-body rod protein FlgB YP_403661.1 1889267 R 300267 CDS YP_009000756.1 578793223 18263070 1889767..1890039 1 NC_007606.1 insertion element iso-IS1N protein InsA 1890039 18263070 SDY_4685 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000756.1 1889767 D 300267 CDS YP_403662.1 82777313 3799511 1890066..1890461 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1890461 3799511 SDY_2079 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403662.1 1890066 D 300267 CDS YP_403663.1 82777314 3799512 1890612..1891271 1 NC_007606.1 flagellar biosynthesis; required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1891271 flgA 3799512 flgA Shigella dysenteriae Sd197 flagellar basal body P-ring biosynthesis protein FlgA YP_403663.1 1890612 D 300267 CDS YP_403664.1 82777315 3799513 1891347..1891640 1 NC_007606.1 anti-sigma factor; also known as RflB protein; regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM 1891640 flgM 3799513 flgM Shigella dysenteriae Sd197 anti-sigma-28 factor FlgM YP_403664.1 1891347 D 300267 CDS YP_403665.1 82777316 3799515 complement(1892093..1893628) 1 NC_007606.1 Code: R; COG: COG0728; virulence factor 1893628 mviN 3799515 mviN Shigella dysenteriae Sd197 virulence factor YP_403665.1 1892093 R 300267 CDS YP_403666.1 82777317 3799516 complement(1893738..1894661) 1 NC_007606.1 Code: R; COG: COG0673; virulence factor 1894661 mviM 3799516 mviM Shigella dysenteriae Sd197 virulence factor YP_403666.1 1893738 R 300267 CDS YP_403667.1 82777318 3799517 complement(1894663..1895310) 1 NC_007606.1 Code: S; COG: COG3132; hypothetical protein 1895310 yceH 3799517 yceH Shigella dysenteriae Sd197 hypothetical protein YP_403667.1 1894663 R 300267 CDS YP_403668.1 82777319 3798842 complement(1895321..1895905) 1 NC_007606.1 Code: J; COG: COG1670; ribosomal-protein-S5-alanine N-acetyltransferase 1895905 rimJ 3798842 rimJ Shigella dysenteriae Sd197 ribosomal-protein-S5-alanine N-acetyltransferase YP_403668.1 1895321 R 300267 CDS YP_403669.1 82777320 3798843 complement(1896075..1896470) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1896470 3798843 SDY_2087 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403669.1 1896075 R 300267 CDS YP_009000757.1 578793224 18263071 complement(1896497..1896769) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1896769 18263071 SDY_4686 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000757.1 1896497 R 300267 CDS YP_403671.1 82777322 3798845 1898185..1898832 1 NC_007606.1 cofactor involved in the reduction of disulfides; glutaredoxin 1898832 grxB 3798845 grxB Shigella dysenteriae Sd197 glutaredoxin YP_403671.1 1898185 D 300267 CDS YP_403672.1 82777323 3798846 1898966..1899526 1 NC_007606.1 hypothetical protein 1899526 yceB 3798846 yceB Shigella dysenteriae Sd197 hypothetical protein YP_403672.1 1898966 D 300267 CDS YP_403673.1 82777324 3798847 1899632..1900678 1 NC_007606.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1900678 pyrC 3798847 pyrC Shigella dysenteriae Sd197 dihydroorotase YP_403673.1 1899632 D 300267 CDS YP_403674.1 82777325 3798848 1900752..1900997 1 NC_007606.1 DNA damage-inducible protein I 1900997 dinI 3798848 dinI Shigella dysenteriae Sd197 DNA damage-inducible protein I YP_403674.1 1900752 D 300267 CDS YP_403675.1 82777326 3798849 complement(1901073..1901468) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1901468 3798849 SDY_2093 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403675.1 1901073 R 300267 CDS YP_009000758.1 578793225 18263072 complement(1901495..1901767) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1901767 18263072 SDY_4687 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000758.1 1901495 R 300267 CDS YP_403677.1 82777328 3798851 1902061..1902315 1 NC_007606.1 ''BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing''; biofilm formation regulatory protein BssS 1902315 bssS 3798851 bssS Shigella dysenteriae Sd197 biofilm formation regulatory protein BssS YP_403677.1 1902061 D 300267 CDS YP_403678.1 82777329 3798852 1902430..1903548 1 NC_007606.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1903548 solA 3798852 solA Shigella dysenteriae Sd197 N-methyltryptophan oxidase YP_403678.1 1902430 D 300267 CDS YP_403679.1 82777330 3798853 1903569..1903709 1 NC_007606.1 hypothetical protein 1903709 yceO 3798853 yceO Shigella dysenteriae Sd197 hypothetical protein YP_403679.1 1903569 D 300267 CDS YP_403680.1 82777331 3798854 complement(1903913..1904308) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1904308 3798854 SDY_2098 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403680.1 1903913 R 300267 CDS YP_009000759.1 578793226 18263073 complement(1904335..1904607) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1904607 18263073 SDY_4688 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000759.1 1904335 R 300267 CDS YP_403681.1 82777332 3798855 complement(1904733..1905392) 1 NC_007606.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 1905392 yeiL 3798855 yeiL Shigella dysenteriae Sd197 DNA-binding transcriptional activator YeiL YP_403681.1 1904733 R 300267 CDS YP_403682.2 161950099 3798856 complement(1905416..1905811) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1905811 3798856 SDY_2100 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403682.2 1905416 R 300267 CDS YP_009000760.1 578793227 18263074 complement(1905838..1906110) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1906110 18263074 SDY_4689 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000760.1 1905838 R 300267 CDS YP_403685.1 82777336 3798859 complement(1906920..1907195) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 1907195 insA 3798859 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_403685.1 1906920 R 300267 CDS YP_403686.1 82777337 3798860 1907237..1908052 1 NC_007606.1 Code: F; COG: COG1957; hypothetical protein 1908052 yeiK 3798860 yeiK Shigella dysenteriae Sd197 hypothetical protein YP_403686.1 1907237 D 300267 CDS YP_403687.1 82777338 3798861 1908152..1909402 1 NC_007606.1 Code: F; COG: COG1972; transport system permease 1909402 yeiJ 3798861 yeiJ Shigella dysenteriae Sd197 transport system permease YP_403687.1 1908152 D 300267 CDS YP_403688.1 82777339 3798862 complement(1909458..1910546) 1 NC_007606.1 Code: G; COG: COG0524; hypothetical protein 1910546 yeiI 3798862 yeiI Shigella dysenteriae Sd197 hypothetical protein YP_403688.1 1909458 R 300267 CDS YP_403689.1 82777340 3798863 complement(1910549..1911406) 1 NC_007606.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 1911406 nfo 3798863 nfo Shigella dysenteriae Sd197 endonuclease IV YP_403689.1 1910549 R 300267 CDS YP_403690.1 82777341 3798864 complement(1911480..1912529) 1 NC_007606.1 Code: S; COG: COG2855; hypothetical protein 1912529 yeiH 3798864 yeiH Shigella dysenteriae Sd197 hypothetical protein YP_403690.1 1911480 R 300267 CDS YP_403691.1 82777342 3798865 1912628..1913509 1 NC_007606.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 1913509 yeiE 3798865 yeiE Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YP_403691.1 1912628 D 300267 CDS YP_403692.1 82777343 3798866 1913714..1915183 1 NC_007606.1 Code: E; COG: COG0833; lysine transporter 1915183 lysP 3798866 lysP Shigella dysenteriae Sd197 lysine transporter YP_403692.1 1913714 D 300267 CDS YP_403693.1 82777344 3798868 complement(1917488..1918324) 1 NC_007606.1 Code: R; COG: COG0627; esterase 1918324 yeiG 3798868 yeiG Shigella dysenteriae Sd197 esterase YP_403693.1 1917488 R 300267 CDS YP_403694.1 82777345 3798869 complement(1918252..1918536) 1 NC_007606.1 hypothetical protein 1918536 3798869 SDY_2113 Shigella dysenteriae Sd197 hypothetical protein YP_403694.1 1918252 R 300267 CDS YP_009000761.1 578793228 18263075 1918432..1918704 1 NC_007606.1 insertion element iso-IS1N protein InsA 1918704 18263075 SDY_4690 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000761.1 1918432 D 300267 CDS YP_403696.1 82777347 3798871 complement(1919220..1919627) 1 NC_007606.1 bacteriophage protein 1919627 3798871 SDY_2115 Shigella dysenteriae Sd197 bacteriophage protein YP_403696.1 1919220 R 300267 CDS YP_403697.1 82777348 3798872 complement(1919856..1920797) 1 NC_007606.1 bacteriophage protein 1920797 3798872 SDY_2116 Shigella dysenteriae Sd197 bacteriophage protein YP_403697.1 1919856 R 300267 CDS YP_403700.1 82777351 3798875 complement(1921319..1922191) 1 NC_007606.1 bacteriophage protein 1922191 3798875 SDY_2119 Shigella dysenteriae Sd197 bacteriophage protein YP_403700.1 1921319 R 300267 CDS YP_403701.1 82777352 3798876 complement(1922269..1922532) 1 NC_007606.1 hypothetical protein 1922532 3798876 SDY_2120 Shigella dysenteriae Sd197 hypothetical protein YP_403701.1 1922269 R 300267 CDS YP_403702.1 82777353 3798877 complement(1923170..1924252) 1 NC_007606.1 bacteriophage protein 1924252 3798877 SDY_2121 Shigella dysenteriae Sd197 bacteriophage protein YP_403702.1 1923170 R 300267 CDS YP_403703.1 82777354 3798878 complement(1924345..1924722) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1924722 insB 3798878 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403703.1 1924345 R 300267 CDS YP_403704.1 82777355 3798879 1925132..1926613 1 NC_007606.1 Code: P; COG: COG3119; sulfatase 1926613 3798879 SDY_2123 Shigella dysenteriae Sd197 sulfatase YP_403704.1 1925132 D 300267 CDS YP_009000762.1 578793229 18263076 1927144..1927416 1 NC_007606.1 insertion element iso-IS1N protein InsA 1927416 18263076 SDY_4691 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000762.1 1927144 D 300267 CDS YP_403706.1 82777357 3796520 complement(1927702..1928079) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1928079 insB 3796520 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403706.1 1927702 R 300267 CDS YP_403708.1 82777359 3796522 1928844..1929512 1 NC_007606.1 ''involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer''; GTP cyclohydrolase I 1929512 folE 3796522 folE Shigella dysenteriae Sd197 GTP cyclohydrolase I YP_403708.1 1928844 D 300267 CDS YP_403710.1 82777361 3796524 1930827..1931867 1 NC_007606.1 galactose operon inducer; negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 1931867 galS 3796524 galS Shigella dysenteriae Sd197 DNA-binding transcriptional regulator GalS YP_403710.1 1930827 D 300267 CDS YP_403711.1 82777362 3796525 1932147..1933145 1 NC_007606.1 receptor for galactose taxis; Code: G; COG: COG1879; galactose-binding transport protein 1933145 mglB 3796525 mglB Shigella dysenteriae Sd197 galactose-binding transport protein YP_403711.1 1932147 D 300267 CDS YP_403713.1 82777364 3796527 1933756..1934151 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1934151 3796527 SDY_2132 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403713.1 1933756 D 300267 CDS YP_403714.1 82777365 3796529 1935402..1935779 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1935779 insB 3796529 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403714.1 1935402 D 300267 CDS YP_403715.1 82777366 3796530 complement(1936153..1936530) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 1936530 insB 3796530 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403715.1 1936153 R 300267 CDS YP_403716.1 82777367 3796531 complement(1936575..1936850) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 1936850 insA 3796531 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403716.1 1936575 R 300267 CDS YP_403717.1 82777368 3796532 1936984..1937877 1 NC_007606.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 1937877 mglC 3796532 mglC Shigella dysenteriae Sd197 beta-methylgalactoside transporter inner membrane protein YP_403717.1 1936984 D 300267 CDS YP_403718.1 82777369 3796533 complement(1938145..1938540) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1938540 3796533 SDY_2138 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403718.1 1938145 R 300267 CDS YP_009000763.1 578793230 18263077 complement(1938567..1938839) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1938839 18263077 SDY_4692 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000763.1 1938567 R 300267 CDS YP_009000764.1 578793231 18263078 complement(1938875..1939957) 1 NC_007606.1 dihydropyrimidine dehydrogenase 1939957 18263078 SDY_2140a Shigella dysenteriae Sd197 dihydropyrimidine dehydrogenase YP_009000764.1 1938875 R 300267 CDS YP_009000765.1 578793232 18263079 1941264..1941536 1 NC_007606.1 insertion element iso-IS1N protein InsA 1941536 18263079 SDY_4693 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000765.1 1941264 D 300267 CDS YP_403720.1 82777371 3796536 1941563..1941958 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1941958 3796536 SDY_2141 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403720.1 1941563 D 300267 CDS YP_403721.1 82777372 3796537 complement(1942157..1942396) 1 NC_007606.1 hypothetical protein 1942396 3796537 SDY_2142 Shigella dysenteriae Sd197 hypothetical protein YP_403721.1 1942157 R 300267 CDS YP_403722.1 82777373 3796538 complement(1942399..1943118) 1 NC_007606.1 Code: S; COG: COG2949; hypothetical protein 1943118 sanA 3796538 sanA Shigella dysenteriae Sd197 hypothetical protein YP_403722.1 1942399 R 300267 CDS YP_403723.1 82777374 3798920 complement(1943268..1944152) 1 NC_007606.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 1944152 cdd 3798920 cdd Shigella dysenteriae Sd197 cytidine deaminase YP_403723.1 1943268 R 300267 CDS YP_403724.1 82777375 3798921 complement(1944282..1944977) 1 NC_007606.1 Code: M; COG: COG1346; hypothetical protein 1944977 yohK 3798921 yohK Shigella dysenteriae Sd197 hypothetical protein YP_403724.1 1944282 R 300267 CDS YP_403725.1 82777376 3798922 complement(1944974..1945372) 1 NC_007606.1 Code: R; COG: COG1380; hypothetical protein 1945372 yohJ 3798922 yohJ Shigella dysenteriae Sd197 hypothetical protein YP_403725.1 1944974 R 300267 CDS YP_403727.1 82777378 3798924 complement(1946879..1947274) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 1947274 3798924 SDY_2148 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403727.1 1946879 R 300267 CDS YP_009000766.1 578793233 18263080 complement(1947301..1947573) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1947573 18263080 SDY_4694 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000766.1 1947301 R 300267 CDS YP_403730.1 82777381 3798927 1949351..1950112 1 NC_007606.1 Code: IQR; COG: COG1028; acetoin dehydrogenase 1950112 yohF 3798927 yohF Shigella dysenteriae Sd197 acetoin dehydrogenase YP_403730.1 1949351 D 300267 CDS YP_403731.1 82777382 3798928 complement(1950242..1950856) 1 NC_007606.1 Code: S; COG: COG0586; hypothetical protein 1950856 yohD 3798928 yohD Shigella dysenteriae Sd197 hypothetical protein YP_403731.1 1950242 R 300267 CDS YP_403732.1 82777383 3798929 1950966..1951577 1 NC_007606.1 hypothetical protein 1951577 yohC 3798929 yohC Shigella dysenteriae Sd197 hypothetical protein YP_403732.1 1950966 D 300267 CDS YP_403733.1 82777384 3798930 1951742..1952683 1 NC_007606.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 1952683 pbpG 3798930 pbpG Shigella dysenteriae Sd197 D-alanyl-D-alanine endopeptidase YP_403733.1 1951742 D 300267 CDS YP_403734.1 82777385 3798931 complement(1952722..1954437) 1 NC_007606.1 ''component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent''; D-lactate dehydrogenase 1954437 dld 3798931 dld Shigella dysenteriae Sd197 D-lactate dehydrogenase YP_403734.1 1952722 R 300267 CDS YP_403735.1 82777386 3798932 1954633..1956930 1 NC_007606.1 Code: G; COG: COG1472; beta-D-glucoside glucohydrolase 1956930 bglX 3798932 bglX Shigella dysenteriae Sd197 beta-D-glucoside glucohydrolase YP_403735.1 1954633 D 300267 CDS YP_403736.1 82777387 3798933 1957182..1958099 1 NC_007606.1 Code: M; COG: COG1732; transport system permease 1958099 yehZ 3798933 yehZ Shigella dysenteriae Sd197 transport system permease YP_403736.1 1957182 D 300267 CDS YP_403737.1 82777388 3798936 1960183..1960914 1 NC_007606.1 Code: E; COG: COG1174; transport system permease 1960914 yehW 3798936 yehW Shigella dysenteriae Sd197 transport system permease YP_403737.1 1960183 D 300267 CDS YP_403738.1 82777389 3798937 complement(1960895..1961002) 1 NC_007606.1 hypothetical protein 1961002 3798937 SDY_2161 Shigella dysenteriae Sd197 hypothetical protein YP_403738.1 1960895 R 300267 CDS YP_403739.1 82777390 3798938 complement(1961062..1961793) 1 NC_007606.1 Code: K; COG: COG0789; transcriptional regulator 1961793 yehV 3798938 yehV Shigella dysenteriae Sd197 transcriptional regulator YP_403739.1 1961062 R 300267 CDS YP_403740.1 82777391 3798939 1962015..1963700 1 NC_007606.1 Code: T; COG: COG3275; 2-component sensor protein 1963700 yehU 3798939 yehU Shigella dysenteriae Sd197 2-component sensor protein YP_403740.1 1962015 D 300267 CDS YP_403741.1 82777392 3799228 1963682..1964416 1 NC_007606.1 unknown function; when overproduced it confers drug-resistance; two-component response-regulator YehT 1964416 yehT 3799228 yehT Shigella dysenteriae Sd197 two-component response-regulator YehT YP_403741.1 1963682 D 300267 CDS YP_403742.1 82777393 3799229 1964463..1964933 1 NC_007606.1 Code: S; COG: COG4807; hypothetical protein 1964933 yehS 3799229 yehS Shigella dysenteriae Sd197 hypothetical protein YP_403742.1 1964463 D 300267 CDS YP_403743.1 82777394 3799230 complement(1964975..1965448) 1 NC_007606.1 Code: S; COG: COG4808; hypothetical protein 1965448 yehR 3799230 yehR Shigella dysenteriae Sd197 hypothetical protein YP_403743.1 1964975 R 300267 CDS YP_403744.1 82777395 3799231 complement(1965561..1966532) 1 NC_007606.1 hypothetical protein 1966532 3799231 SDY_2167 Shigella dysenteriae Sd197 hypothetical protein YP_403744.1 1965561 R 300267 CDS YP_403745.2 161950098 3799232 complement(1966560..1967465) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1967465 3799232 SDY_2168 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_403745.2 1966560 R 300267 CDS YP_403746.1 82777397 3799233 complement(1967423..1967788) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 1967788 3799233 SDY_2169 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_403746.1 1967423 R 300267 CDS YP_403747.1 82777398 3799234 complement(1967830..1968921) 1 NC_007606.1 Code: L; COG: COG2801; hypothetical protein 1968921 3799234 SDY_2170 Shigella dysenteriae Sd197 hypothetical protein YP_403747.1 1967830 R 300267 CDS YP_009000767.1 578793234 18263081 1972241..1972513 1 NC_007606.1 insertion element iso-IS1N protein InsA 1972513 18263081 SDY_4695 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000767.1 1972241 D 300267 CDS YP_403752.1 82777403 3799239 1972540..1972935 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1972935 3799239 SDY_2175 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403752.1 1972540 D 300267 CDS YP_403755.1 82777406 3799242 complement(1976253..1976651) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 1976651 3799242 SDY_2178 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403755.1 1976253 R 300267 CDS YP_009000768.1 578793235 18263082 complement(1976678..1976950) 1 NC_007606.1 insertion element iso-IS1N protein InsA 1976950 18263082 SDY_4696 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000768.1 1976678 R 300267 CDS YP_403756.1 82777407 3799243 complement(1976986..1977411) 1 NC_007606.1 hypothetical protein 1977411 3799243 SDY_2179 Shigella dysenteriae Sd197 hypothetical protein YP_403756.1 1976986 R 300267 CDS YP_403757.1 82777408 3799244 complement(1977371..1978459) 1 NC_007606.1 hypothetical protein 1978459 3799244 SDY_2180 Shigella dysenteriae Sd197 hypothetical protein YP_403757.1 1977371 R 300267 CDS YP_403758.1 82777409 3799245 complement(1978813..1980846) 1 NC_007606.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1980846 metG 3799245 metG Shigella dysenteriae Sd197 methionyl-tRNA synthetase YP_403758.1 1978813 R 300267 CDS YP_403759.2 161950097 3799246 1980978..1982087 1 NC_007606.1 Code: D; COG: COG0489; ATPase 1982087 mrp 3799246 mrp Shigella dysenteriae Sd197 ATPase YP_403759.2 1980978 D 300267 CDS YP_403760.1 82777411 3799363 1982350..1982613 1 NC_007606.1 hypothetical protein 1982613 yehE 3799363 yehE Shigella dysenteriae Sd197 hypothetical protein YP_403760.1 1982350 D 300267 CDS YP_403761.1 82777412 3799364 1982665..1982967 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 1982967 3799364 SDY_2184 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403761.1 1982665 D 300267 CDS YP_403762.1 82777413 3799365 1983108..1983923 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 1983923 3799365 SDY_2185 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_403762.1 1983108 D 300267 CDS YP_009000769.1 578793236 18263083 complement(1983848..1984147) 1 NC_007606.1 hypothetical protein 1984147 18263083 DY_2185a Shigella dysenteriae Sd197 hypothetical protein YP_009000769.1 1983848 R 300267 CDS YP_403763.1 82777414 3799366 complement(1984338..1985060) 1 NC_007606.1 sensor BaeS; ''response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport''; DNA-binding transcriptional regulator BaeR 1985060 baeR 3799366 baeR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator BaeR YP_403763.1 1984338 R 300267 CDS YP_403764.1 82777415 3799367 complement(1985057..1986460) 1 NC_007606.1 Code: T; COG: COG0642; signal transduction histidine-protein kinase BaeS 1986460 baeS 3799367 baeS Shigella dysenteriae Sd197 signal transduction histidine-protein kinase BaeS YP_403764.1 1985057 R 300267 CDS YP_403765.1 82777416 3799368 complement(1986354..1987400) 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 1987400 yegB 3799368 yegB Shigella dysenteriae Sd197 transport protein YP_403765.1 1986354 R 300267 CDS YP_403766.1 82777417 3799369 complement(1987467..1988663) 1 NC_007606.1 Code: L; COG: COG3547; insertion element IS110 transposase 1988663 3799369 SDY_2189 Shigella dysenteriae Sd197 insertion element IS110 transposase YP_403766.1 1987467 R 300267 CDS YP_403767.1 82777418 3799370 1989099..1989758 1 NC_007606.1 Code: R; COG: COG4245; hypothetical protein 1989758 3799370 SDY_2190 Shigella dysenteriae Sd197 hypothetical protein YP_403767.1 1989099 D 300267 CDS YP_403768.1 82777419 3799371 1989755..1990516 1 NC_007606.1 hypothetical protein 1990516 3799371 SDY_2191 Shigella dysenteriae Sd197 hypothetical protein YP_403768.1 1989755 D 300267 CDS YP_403769.1 82777420 3799372 1990513..1992453 1 NC_007606.1 Code: R; COG: COG4248; chaperonin 1992453 3799372 SDY_2192 Shigella dysenteriae Sd197 chaperonin YP_403769.1 1990513 D 300267 CDS YP_403770.2 161950096 3799373 complement(1992465..1993817) 1 NC_007606.1 Code: O; COG: COG0443; chaperone 1993817 yegD 3799373 yegD Shigella dysenteriae Sd197 chaperone YP_403770.2 1992465 R 300267 CDS YP_403771.1 82777422 3799374 1993951..1994799 1 NC_007606.1 ''inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine''; 3-methyladenine DNA glycosylase 1994799 alkA 3799374 alkA Shigella dysenteriae Sd197 3-methyladenine DNA glycosylase YP_403771.1 1993951 D 300267 CDS YP_403772.2 161950095 3799376 1998534..1999175 1 NC_007606.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1999175 udk 3799376 udk Shigella dysenteriae Sd197 uridine kinase YP_403772.2 1998534 D 300267 CDS YP_403773.1 82777424 3799377 1999267..1999848 1 NC_007606.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1999848 dcd 3799377 dcd Shigella dysenteriae Sd197 deoxycytidine triphosphate deaminase YP_403773.1 1999267 D 300267 CDS YP_403774.1 82777425 3799378 1999870..2001723 1 NC_007606.1 ''YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs''; assembly protein 2001723 asmA 3799378 asmA Shigella dysenteriae Sd197 assembly protein YP_403774.1 1999870 D 300267 CDS YP_403775.1 82777426 3799379 complement(2001776..2002066) 1 NC_007606.1 Code: S; COG: COG5606; hypothetical protein 2002066 3799379 SDY_2199 Shigella dysenteriae Sd197 hypothetical protein YP_403775.1 2001776 R 300267 CDS YP_403776.1 82777427 3799380 complement(2002056..2002277) 1 NC_007606.1 hypothetical protein 2002277 3799380 SDY_2200 Shigella dysenteriae Sd197 hypothetical protein YP_403776.1 2002056 R 300267 CDS YP_403777.1 82777428 3799381 complement(2002615..2004237) 1 NC_007606.1 Code: R; COG: COG1253; transport protein 2004237 yegH 3799381 yegH Shigella dysenteriae Sd197 transport protein YP_403777.1 2002615 R 300267 CDS YP_009000770.1 578793237 18263084 2004604..2004876 1 NC_007606.1 insertion element iso-IS1N protein InsA 2004876 18263084 SDY_4697 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000770.1 2004604 D 300267 CDS YP_403778.1 82777429 3799382 2004903..2005298 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2005298 3799382 SDY_2202 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403778.1 2004903 D 300267 CDS YP_403779.1 82777430 3797481 2005517..2006410 1 NC_007606.1 ''together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose''; UTP-glucose-1-phosphate uridylyltransferase 2006410 galF 3797481 galF Shigella dysenteriae Sd197 UTP-glucose-1-phosphate uridylyltransferase YP_403779.1 2005517 D 300267 CDS YP_403780.1 82777431 3797482 2006782..2007867 1 NC_007606.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose-4,6-dehydratase 2007867 rfbB 3797482 rfbB Shigella dysenteriae Sd197 dTDP-glucose-4,6-dehydratase YP_403780.1 2006782 D 300267 CDS YP_403781.1 82777432 3797483 2007867..2008766 1 NC_007606.1 ''with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose''; dTDP-4-dehydrorhamnose reductase 2008766 rfbD 3797483 rfbD Shigella dysenteriae Sd197 dTDP-4-dehydrorhamnose reductase YP_403781.1 2007867 D 300267 CDS YP_403782.1 82777433 3797484 2008824..2009702 1 NC_007606.1 Code: M; COG: COG1209; glucose-1-phosphate thymidylyltransferase 2009702 rfbA 3797484 rfbA Shigella dysenteriae Sd197 glucose-1-phosphate thymidylyltransferase YP_403782.1 2008824 D 300267 CDS YP_403783.1 82777434 3797485 2009705..2010262 1 NC_007606.1 Code: M; COG: COG1898; dTDP-4-dehydrorhamnose 3,5-epimerase 2010262 rfbC 3797485 rfbC Shigella dysenteriae Sd197 dTDP-4-dehydrorhamnose 3,5-epimerase YP_403783.1 2009705 D 300267 CDS YP_403784.1 82777435 3797486 2010259..2011449 1 NC_007606.1 Code: R; COG: COG2244; O-antigen transporter 2011449 rfbX 3797486 rfbX Shigella dysenteriae Sd197 O-antigen transporter YP_403784.1 2010259 D 300267 CDS YP_403785.1 82777436 3797487 2011446..2012588 1 NC_007606.1 O-antigen polymerase 2012588 rfc 3797487 rfc Shigella dysenteriae Sd197 O-antigen polymerase YP_403785.1 2011446 D 300267 CDS YP_403786.1 82777437 3797488 2012581..2013429 1 NC_007606.1 rhamnosyl transferase II 2013429 rfbR 3797488 rfbR Shigella dysenteriae Sd197 rhamnosyl transferase II YP_403786.1 2012581 D 300267 CDS YP_403787.1 82777438 3797489 2013454..2014365 1 NC_007606.1 rhamnosyl transferase I 2014365 rfbQ 3797489 rfbQ Shigella dysenteriae Sd197 rhamnosyl transferase I YP_403787.1 2013454 D 300267 CDS YP_403788.1 82777439 3797490 2015551..2016957 1 NC_007606.1 decarboxylating; catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2016957 gnd 3797490 gnd Shigella dysenteriae Sd197 6-phosphogluconate dehydrogenase YP_403788.1 2015551 D 300267 CDS YP_403789.1 82777440 3797491 2017207..2018373 1 NC_007606.1 Code: M; COG: COG1004; UDP-glucose 6-dehydrogenase 2018373 ugd 3797491 ugd Shigella dysenteriae Sd197 UDP-glucose 6-dehydrogenase YP_403789.1 2017207 D 300267 CDS YP_403790.1 82777441 3797492 2018463..2019497 1 NC_007606.1 Code: M; COG: COG3765; O-antigen chain length regulator 2019497 wzzB 3797492 wzzB Shigella dysenteriae Sd197 O-antigen chain length regulator YP_403790.1 2018463 D 300267 CDS YP_403791.1 82777442 3797493 complement(2019594..2020205) 1 NC_007606.1 phosphoribosyl-ATP pyrophosphatase; catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2020205 hisI 3797493 hisI Shigella dysenteriae Sd197 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_403791.1 2019594 R 300267 CDS YP_403792.1 82777443 3797494 complement(2020199..2020975) 1 NC_007606.1 imidazole glycerol phsphate synthase holoenzyme; ''catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase''; imidazole glycerol phosphate synthase subunit HisF 2020975 hisF 3797494 hisF Shigella dysenteriae Sd197 imidazole glycerol phosphate synthase subunit HisF YP_403792.1 2020199 R 300267 CDS YP_403793.2 161950094 3797495 complement(2020957..2021694) 1 NC_007606.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2021694 hisA 3797495 hisA Shigella dysenteriae Sd197 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_403793.2 2020957 R 300267 CDS YP_403794.1 82777445 3797496 complement(2021694..2022284) 1 NC_007606.1 imidazole glycerol phosphate synthase holoenzyme; ''with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide''; imidazole glycerol phosphate synthase subunit HisH 2022284 hisH 3797496 hisH Shigella dysenteriae Sd197 imidazole glycerol phosphate synthase subunit HisH YP_403794.1 2021694 R 300267 CDS YP_403795.2 161950093 3797497 complement(2022284..2023351) 1 NC_007606.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2023351 hisB 3797497 hisB Shigella dysenteriae Sd197 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_403795.2 2022284 R 300267 CDS YP_403796.1 82777447 3797498 complement(2023351..2024421) 1 NC_007606.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2024421 hisC 3797498 hisC Shigella dysenteriae Sd197 histidinol-phosphate aminotransferase YP_403796.1 2023351 R 300267 CDS YP_403797.1 82777448 3797499 complement(2024418..2025722) 1 NC_007606.1 L-histidinol:NAD+ oxidoreductase; catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2025722 hisD 3797499 hisD Shigella dysenteriae Sd197 histidinol dehydrogenase YP_403797.1 2024418 R 300267 CDS YP_403798.1 82777449 3797143 complement(2025728..2026627) 1 NC_007606.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2026627 hisG 3797143 hisG Shigella dysenteriae Sd197 ATP phosphoribosyltransferase YP_403798.1 2025728 R 300267 CDS YP_403799.1 82777450 3797144 2027230..2028054 1 NC_007606.1 Code: MG; COG: COG0451; nucleoside-diphosphate-sugar epimerase 2028054 3797144 SDY_2223 Shigella dysenteriae Sd197 nucleoside-diphosphate-sugar epimerase YP_403799.1 2027230 D 300267 CDS YP_403802.1 82777453 3797147 2029290..2030654 1 NC_007606.1 Code: E; COG: COG0531; amino acid/amine transport protein 2030654 yeeF 3797147 yeeF Shigella dysenteriae Sd197 amino acid/amine transport protein YP_403802.1 2029290 D 300267 CDS YP_403803.2 161950092 3797149 complement(2031174..2032079) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2032079 3797149 SDY_2228 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_403803.2 2031174 R 300267 CDS YP_403804.1 82777455 3797150 complement(2032037..2032402) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2032402 3797150 SDY_2229 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_403804.1 2032037 R 300267 CDS YP_403805.1 82777456 3797151 2033229..2033456 1 NC_007606.1 Code: O; COG: COG0425; hypothetical protein 2033456 yeeD 3797151 yeeD Shigella dysenteriae Sd197 hypothetical protein YP_403805.1 2033229 D 300267 CDS YP_403806.1 82777457 3797152 complement(2033499..2034926) 1 NC_007606.1 3' --> 5' specific; deoxyribophosphodiesterase; Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2034926 sbcB 3797152 sbcB Shigella dysenteriae Sd197 exonuclease I YP_403806.1 2033499 R 300267 CDS YP_403807.1 82777458 3797153 complement(2035177..2035572) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2035572 3797153 SDY_2232 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403807.1 2035177 R 300267 CDS YP_009000771.1 578793238 18263085 complement(2035599..2035871) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2035871 18263085 SDY_4698 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000771.1 2035599 R 300267 CDS YP_403808.1 82777459 3797154 2035938..2037074 1 NC_007606.1 ''removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''; D-alanyl-D-alanine carboxypeptidase 2037074 dacD 3797154 dacD Shigella dysenteriae Sd197 D-alanyl-D-alanine carboxypeptidase YP_403808.1 2035938 D 300267 CDS YP_009000772.1 578793239 18263086 2037591..2037863 1 NC_007606.1 insertion element iso-IS1N protein InsA 2037863 18263086 SDY_4699 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000772.1 2037591 D 300267 CDS YP_403809.1 82777460 3797156 2037890..2038285 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2038285 3797156 SDY_2235 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403809.1 2037890 D 300267 CDS YP_403810.1 82777461 3797157 2038639..2039697 1 NC_007606.1 Code: S; COG: COG1289; hypothetical protein 2039697 yeeA 3797157 yeeA Shigella dysenteriae Sd197 hypothetical protein YP_403810.1 2038639 D 300267 CDS YP_403811.1 82777462 3797158 2039803..2040198 1 NC_007606.1 Code: S; COG: COG2926; hypothetical protein 2040198 yeeX 3797158 yeeX Shigella dysenteriae Sd197 hypothetical protein YP_403811.1 2039803 D 300267 CDS YP_403812.1 82777463 3797159 complement(2040427..2040822) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2040822 3797159 SDY_2238 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403812.1 2040427 R 300267 CDS YP_403813.1 82777464 3797160 2041017..2041358 1 NC_007606.1 hypothetical protein 2041358 3797160 SDY_2239 Shigella dysenteriae Sd197 hypothetical protein YP_403813.1 2041017 D 300267 CDS YP_403814.1 82777465 3797161 2041772..2042317 1 NC_007606.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2042317 cobU 3797161 cobU Shigella dysenteriae Sd197 adenosylcobinamide kinase YP_403814.1 2041772 D 300267 CDS YP_403815.1 82777466 3797162 2042314..2043057 1 NC_007606.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2043057 cobS 3797162 cobS Shigella dysenteriae Sd197 cobalamin synthase YP_403815.1 2042314 D 300267 CDS YP_403816.1 82777467 3796976 2043069..2044148 1 NC_007606.1 ''catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole''; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2044148 cobT 3796976 cobT Shigella dysenteriae Sd197 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_403816.1 2043069 D 300267 CDS YP_403817.1 82777468 3796977 2044213..2045145 1 NC_007606.1 Code: S; COG: COG1376; hypothetical protein 2045145 erfK 3796977 erfK Shigella dysenteriae Sd197 hypothetical protein YP_403817.1 2044213 D 300267 CDS YP_403818.1 82777469 3796979 2045602..2046519 1 NC_007606.1 ''Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation''; nitrogen assimilation transcriptional regulator 2046519 nac 3796979 nac Shigella dysenteriae Sd197 nitrogen assimilation transcriptional regulator YP_403818.1 2045602 D 300267 CDS YP_403819.1 82777470 3796980 2046621..2047571 1 NC_007606.1 accessory regulatory circuit affecting cysM; LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2047571 cbl 3796980 cbl Shigella dysenteriae Sd197 transcriptional regulator Cbl YP_403819.1 2046621 D 300267 CDS YP_403820.1 82777471 3796982 2048019..2048519 1 NC_007606.1 hypothetical protein 2048519 3796982 SDY_2248 Shigella dysenteriae Sd197 hypothetical protein YP_403820.1 2048019 D 300267 CDS YP_403821.1 82777472 3796983 2048510..2049358 1 NC_007606.1 hypothetical protein 2049358 3796983 SDY_2249 Shigella dysenteriae Sd197 hypothetical protein YP_403821.1 2048510 D 300267 CDS YP_403822.1 82777473 3796985 2049619..2049894 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2049894 insA 3796985 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403822.1 2049619 D 300267 CDS YP_403823.1 82777474 3796986 2049939..2050316 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2050316 insB 3796986 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403823.1 2049939 D 300267 CDS YP_403824.1 82777475 3796987 complement(2050352..2051806) 1 NC_007606.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2051806 amn 3796987 amn Shigella dysenteriae Sd197 AMP nucleosidase YP_403824.1 2050352 R 300267 CDS YP_403825.1 82777476 3796988 complement(2051908..2053224) 1 NC_007606.1 Code: GEPR; COG: COG0477; shikimate transporter 2053224 shiA 3796988 shiA Shigella dysenteriae Sd197 shikimate transporter YP_403825.1 2051908 R 300267 CDS YP_403828.1 82777479 3796991 2054303..2054554 1 NC_007606.1 Code: K; COG: COG3609; hypothetical protein 2054554 3796991 SDY_2257 Shigella dysenteriae Sd197 hypothetical protein YP_403828.1 2054303 D 300267 CDS YP_403829.1 82777480 3797026 2054574..2054852 1 NC_007606.1 Code: R; COG: COG3668; plasmid stabilization protein 2054852 3797026 SDY_2258 Shigella dysenteriae Sd197 plasmid stabilization protein YP_403829.1 2054574 D 300267 CDS YP_403830.1 82777481 3797027 2054955..2056316 1 NC_007606.1 Code: O; COG: COG0826; hypothetical protein 2056316 yegQ 3797027 yegQ Shigella dysenteriae Sd197 hypothetical protein YP_403830.1 2054955 D 300267 CDS YP_403831.1 82777482 3797028 complement(2056646..2056978) 1 NC_007606.1 hypothetical protein 2056978 3797028 SDY_2260 Shigella dysenteriae Sd197 hypothetical protein YP_403831.1 2056646 R 300267 CDS YP_403832.1 82777483 3797029 2057377..2058276 1 NC_007606.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2058276 3797029 SDY_2261 Shigella dysenteriae Sd197 lipid kinase YP_403832.1 2057377 D 300267 CDS YP_403833.1 82777484 3797030 complement(2058358..2059137) 1 NC_007606.1 Code: KG; COG: COG1349; galactitol utilization operon repressor 2059137 gatR 3797030 gatR Shigella dysenteriae Sd197 galactitol utilization operon repressor YP_403833.1 2058358 R 300267 CDS YP_403834.1 82777485 3797031 complement(2059237..2060277) 1 NC_007606.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2060277 gatD 3797031 gatD Shigella dysenteriae Sd197 galactitol-1-phosphate dehydrogenase YP_403834.1 2059237 R 300267 CDS YP_403835.1 82777486 3797033 complement(2061709..2061969) 1 NC_007606.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2061969 gatB 3797033 gatB Shigella dysenteriae Sd197 PTS system galactitol-specific transporter subunit IIB YP_403835.1 2061709 R 300267 CDS YP_403836.1 82777487 3797035 complement(2062586..2062981) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2062981 3797035 SDY_2267 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403836.1 2062586 R 300267 CDS YP_009000773.1 578793240 18263087 complement(2063008..2063280) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2063280 18263087 SDY_4700 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000773.1 2063008 R 300267 CDS YP_403837.2 161950091 3797037 complement(2064363..2065217) 1 NC_007606.1 ''catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway''; tagatose-bisphosphate aldolase 2065217 gatY 3797037 gatY Shigella dysenteriae Sd197 tagatose-bisphosphate aldolase YP_403837.2 2064363 R 300267 CDS YP_403838.2 161950090 3797038 complement(2065447..2066499) 1 NC_007606.1 ''catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate''; fructose-bisphosphate aldolase 2066499 3797038 SDY_2270 Shigella dysenteriae Sd197 fructose-bisphosphate aldolase YP_403838.2 2065447 R 300267 CDS YP_403839.1 82777490 3797039 2066756..2068033 1 NC_007606.1 Code: GEPR; COG: COG0477; nucleoside permease 2068033 yegT 3797039 yegT Shigella dysenteriae Sd197 nucleoside permease YP_403839.1 2066756 D 300267 CDS YP_403840.1 82777491 3797040 2068030..2069034 1 NC_007606.1 Code: O; COG: COG1397; hypothetical protein 2069034 3797040 SDY_2272 Shigella dysenteriae Sd197 hypothetical protein YP_403840.1 2068030 D 300267 CDS YP_403841.1 82777492 3797041 2069031..2069996 1 NC_007606.1 Code: G; COG: COG0524; kinase 2069996 3797041 SDY_2273 Shigella dysenteriae Sd197 kinase YP_403841.1 2069031 D 300267 CDS YP_403842.1 82777493 3797042 complement(2069970..2070716) 1 NC_007606.1 Code: K; COG: COG2188; transcriptional regulator 2070716 yegW 3797042 yegW Shigella dysenteriae Sd197 transcriptional regulator YP_403842.1 2069970 R 300267 CDS YP_403845.1 82777496 3797045 complement(2071651..2072451) 1 NC_007606.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2072451 thiD 3797045 thiD Shigella dysenteriae Sd197 phosphomethylpyrimidine kinase YP_403845.1 2071651 R 300267 CDS YP_403846.1 82777497 3796919 complement(2072448..2073236) 1 NC_007606.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2073236 thiM 3796919 thiM Shigella dysenteriae Sd197 hydroxyethylthiazole kinase YP_403846.1 2072448 R 300267 CDS YP_403847.1 82777498 3796920 complement(2073459..2073731) 1 NC_007606.1 Code: S; COG: COG1937; hypothetical protein 2073731 yohL 3796920 yohL Shigella dysenteriae Sd197 hypothetical protein YP_403847.1 2073459 R 300267 CDS YP_403848.1 82777499 3796921 2073829..2074686 1 NC_007606.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2074686 yohM 3796921 yohM Shigella dysenteriae Sd197 nickel/cobalt efflux protein RcnA YP_403848.1 2073829 D 300267 CDS YP_403849.2 578793241 3796922 2074904..2075242 1 NC_007606.1 Code: S; COG: COG5455; hypothetical protein 2075242 3796922 SDY_2281 Shigella dysenteriae Sd197 hypothetical protein YP_403849.2 2074904 D 300267 CDS YP_009000774.1 578793242 18263088 2075480..2075752 1 NC_007606.1 insertion element iso-IS1N protein InsA 2075752 18263088 SDY_4701 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000774.1 2075480 D 300267 CDS YP_403853.1 82777504 3796926 complement(2076763..2077158) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2077158 3796926 SDY_2285 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403853.1 2076763 R 300267 CDS YP_009000775.1 578793243 18263089 complement(2077185..2077457) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2077457 18263089 SDY_4702 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000775.1 2077185 R 300267 CDS YP_403855.1 82777506 3796928 complement(2077541..2079334) 1 NC_007606.1 Code: NU; COG: COG3188; outer membrane protein 2079334 yehB 3796928 yehB Shigella dysenteriae Sd197 outer membrane protein YP_403855.1 2077541 R 300267 CDS YP_403856.1 82777507 3796929 complement(2079455..2079832) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2079832 insB 3796929 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403856.1 2079455 R 300267 CDS YP_403857.1 82777508 3796930 complement(2079877..2080152) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2080152 insA 3796930 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403857.1 2079877 R 300267 CDS YP_403859.1 82777510 3796932 complement(2080948..2081250) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2081250 3796932 SDY_2291 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403859.1 2080948 R 300267 CDS YP_403860.1 82777511 3796933 complement(2081395..2082447) 1 NC_007606.1 Code: R; COG: COG1054; hypothetical protein 2082447 yceA 3796933 yceA Shigella dysenteriae Sd197 hypothetical protein YP_403860.1 2081395 R 300267 CDS YP_403861.1 82777512 3796934 2082672..2083592 1 NC_007606.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2083592 htrB 3796934 htrB Shigella dysenteriae Sd197 lipid A biosynthesis lauroyl acyltransferase YP_403861.1 2082672 D 300267 CDS YP_403864.1 82777515 3796937 complement(2085138..2085440) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 2085440 3796937 SDY_2296 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_403864.1 2085138 R 300267 CDS YP_403865.1 82777516 3798177 2085936..2086907 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 2086907 yceE 3798177 yceE Shigella dysenteriae Sd197 transport protein YP_403865.1 2085936 D 300267 CDS YP_403866.1 82777517 3798178 2086862..2086960 1 NC_007606.1 hypothetical protein 2086960 3798178 SDY_2298 Shigella dysenteriae Sd197 hypothetical protein YP_403866.1 2086862 D 300267 CDS YP_403867.1 82777518 3798179 2086987..2087364 1 NC_007606.1 suppresses mutants lacking function of protein export; hypothetical protein 2087364 msyB 3798179 msyB Shigella dysenteriae Sd197 hypothetical protein YP_403867.1 2086987 D 300267 CDS YP_403868.1 82777519 3798180 complement(2087365..2087592) 1 NC_007606.1 Code: R; COG: COG5645; hypothetical protein 2087592 yceK 3798180 yceK Shigella dysenteriae Sd197 hypothetical protein YP_403868.1 2087365 R 300267 CDS YP_403869.1 82777520 3798181 complement(2087765..2090308) 1 NC_007606.1 synthesis of membrane-derived oligosaccharide (MDO); necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 2090308 mdoH 3798181 mdoH Shigella dysenteriae Sd197 glucosyltransferase MdoH YP_403869.1 2087765 R 300267 CDS YP_403870.1 82777521 3798182 complement(2090301..2091836) 1 NC_007606.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 2091836 mdoG 3798182 mdoG Shigella dysenteriae Sd197 glucan biosynthesis protein G YP_403870.1 2090301 R 300267 CDS YP_403871.1 82777522 3798183 2092230..2093387 1 NC_007606.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 2093387 mdoC 3798183 mdoC Shigella dysenteriae Sd197 glucans biosynthesis protein YP_403871.1 2092230 D 300267 CDS YP_403872.1 82777523 3798184 complement(2093395..2094876) 1 NC_007606.1 Code: I; COG: COG1502; synthase 2094876 ymdC 3798184 ymdC Shigella dysenteriae Sd197 synthase YP_403872.1 2093395 R 300267 CDS YP_403873.1 82777524 3798185 complement(2094818..2095351) 1 NC_007606.1 Code: R; COG: COG2110; hypothetical protein 2095351 3798185 SDY_2305 Shigella dysenteriae Sd197 hypothetical protein YP_403873.1 2094818 R 300267 CDS YP_403874.1 82777525 3798186 complement(2095446..2095757) 1 NC_007606.1 hypothetical protein 2095757 3798186 SDY_2306 Shigella dysenteriae Sd197 hypothetical protein YP_403874.1 2095446 R 300267 CDS YP_403875.1 82777526 3798187 2096116..2096391 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2096391 insA 3798187 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_403875.1 2096116 D 300267 CDS YP_403876.1 82777527 3798188 2096436..2096813 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2096813 insB 3798188 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403876.1 2096436 D 300267 CDS YP_403879.1 82777530 3798191 complement(2097982..2098569) 1 NC_007606.1 Code: S; COG: COG2353; hypothetical protein 2098569 yceI 3798191 yceI Shigella dysenteriae Sd197 hypothetical protein YP_403879.1 2097982 R 300267 CDS YP_403880.1 82777531 3798192 complement(2098573..2099139) 1 NC_007606.1 Code: C; COG: COG3038; cytochrome 2099139 3798192 SDY_2312 Shigella dysenteriae Sd197 cytochrome YP_403880.1 2098573 R 300267 CDS YP_403881.1 82777532 3798193 complement(2099117..2099380) 1 NC_007606.1 hypothetical protein 2099380 3798193 SDY_2313 Shigella dysenteriae Sd197 hypothetical protein YP_403881.1 2099117 R 300267 CDS YP_009000776.1 578793244 18263090 2099276..2099548 1 NC_007606.1 insertion element iso-IS1N protein InsA 2099548 18263090 SDY_4703 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000776.1 2099276 D 300267 CDS YP_403882.1 82777533 3798194 2099575..2099970 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2099970 3798194 SDY_2314 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403882.1 2099575 D 300267 CDS YP_403883.1 82777534 3798195 complement(2100400..2102091) 1 NC_007606.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC 2102091 fruA 3798195 fruA Shigella dysenteriae Sd197 PTS system fructose-specific transporter subunit IIBC YP_403883.1 2100400 R 300267 CDS YP_403884.1 82777535 3798196 complement(2102108..2103046) 1 NC_007606.1 ''converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers''; 1-phosphofructokinase 2103046 fruK 3798196 fruK Shigella dysenteriae Sd197 1-phosphofructokinase YP_403884.1 2102108 R 300267 CDS YP_403885.1 82777536 3795616 complement(2103046..2104176) 1 NC_007606.1 ''phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr''; bifunctional fructose-specific PTS IIA/HPr protein 2104176 fruB 3795616 fruB Shigella dysenteriae Sd197 bifunctional fructose-specific PTS IIA/HPr protein YP_403885.1 2103046 R 300267 CDS YP_403886.1 82777537 3795617 complement(2104448..2104843) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2104843 3795617 SDY_2318 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403886.1 2104448 R 300267 CDS YP_009000777.1 578793245 18263091 complement(2104870..2105142) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2105142 18263091 SDY_4704 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000777.1 2104870 R 300267 CDS YP_403887.1 82777538 3795618 2105310..2105885 1 NC_007606.1 Code: R; COG: COG0431; NAD(P)H-dependent FMN reductase 2105885 ycbP 3795618 ycbP Shigella dysenteriae Sd197 NAD(P)H-dependent FMN reductase YP_403887.1 2105310 D 300267 CDS YP_403888.1 82777539 3795619 2105878..2106870 1 NC_007606.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 2106870 ycbO 3795619 ycbO Shigella dysenteriae Sd197 alkanesulfonate transporter substrate-binding subunit YP_403888.1 2105878 D 300267 CDS YP_403891.1 82777542 3795622 2107845..2108636 1 NC_007606.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease 2108636 ssuC 3795622 ssuC Shigella dysenteriae Sd197 alkanesulfonate transporter permease YP_403891.1 2107845 D 300267 CDS YP_403893.1 82777544 3795624 complement(2109427..2112039) 1 NC_007606.1 Code: E; COG: COG0308; aminopeptidase 2112039 pepN 3795624 pepN Shigella dysenteriae Sd197 aminopeptidase YP_403893.1 2109427 R 300267 CDS YP_403894.1 82777545 3795625 2112305..2113507 1 NC_007606.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 2113507 pncB 3795625 pncB Shigella dysenteriae Sd197 nicotinate phosphoribosyltransferase YP_403894.1 2112305 D 300267 CDS YP_403895.1 82777546 3795626 2113677..2115077 1 NC_007606.1 ''catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; asparaginyl-tRNA synthetase 2115077 asnC 3795626 asnC Shigella dysenteriae Sd197 asparaginyl-tRNA synthetase YP_403895.1 2113677 D 300267 CDS YP_403896.1 82777547 3795627 2115680..2116768 1 NC_007606.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 2116768 ompF 3795627 ompF Shigella dysenteriae Sd197 outer membrane protein F YP_403896.1 2115680 D 300267 CDS YP_403897.1 82777548 3795628 2116953..2118143 1 NC_007606.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 2118143 aspC 3795628 aspC Shigella dysenteriae Sd197 aromatic amino acid aminotransferase YP_403897.1 2116953 D 300267 CDS YP_403898.1 82777549 3795629 complement(2118193..2118840) 1 NC_007606.1 Code: R; COG: COG0491; hypothetical protein 2118840 ycbL 3795629 ycbL Shigella dysenteriae Sd197 hypothetical protein YP_403898.1 2118193 R 300267 CDS YP_403899.1 82777550 3795630 complement(2118867..2119415) 1 NC_007606.1 Code: S; COG: COG3108; hypothetical protein 2119415 ycbK 3795630 ycbK Shigella dysenteriae Sd197 hypothetical protein YP_403899.1 2118867 R 300267 CDS YP_403900.1 82777551 3795631 complement(2119596..2121443) 1 NC_007606.1 Code: S; COG: COG2989; hypothetical protein 2121443 ycbB 3795631 ycbB Shigella dysenteriae Sd197 hypothetical protein YP_403900.1 2119596 R 300267 CDS YP_403901.1 82777552 3795632 complement(2121629..2122024) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2122024 3795632 SDY_2333 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403901.1 2121629 R 300267 CDS YP_009000778.1 578793246 18263092 complement(2122051..2122323) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2122323 18263092 SDY_4705 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000778.1 2122051 R 300267 CDS YP_403902.1 82777553 3795633 complement(2122426..2126877) 1 NC_007606.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 2126877 mukB 3795633 mukB Shigella dysenteriae Sd197 cell division protein MukB YP_403902.1 2122426 R 300267 CDS YP_403903.1 82777554 3795634 complement(2126877..2127554) 1 NC_007606.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 2127554 mukE 3795634 mukE Shigella dysenteriae Sd197 condesin subunit E YP_403903.1 2126877 R 300267 CDS YP_403904.1 82777555 3795425 complement(2127562..2128884) 1 NC_007606.1 killing factor KICB; acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 2128884 mukF 3795425 mukF Shigella dysenteriae Sd197 condesin subunit F YP_403904.1 2127562 R 300267 CDS YP_403905.1 82777556 3795426 complement(2128881..2129666) 1 NC_007606.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 2129666 smtA 3795426 smtA Shigella dysenteriae Sd197 metallothionein SmtA YP_403905.1 2128881 R 300267 CDS YP_403906.1 82777557 3795427 2129804..2130583 1 NC_007606.1 Code: S; COG: COG1434; hypothetical protein 2130583 ycbC 3795427 ycbC Shigella dysenteriae Sd197 hypothetical protein YP_403906.1 2129804 D 300267 CDS YP_403907.1 82777558 3795428 complement(2130560..2131453) 1 NC_007606.1 hypothetical protein 2131453 3795428 SDY_2339 Shigella dysenteriae Sd197 hypothetical protein YP_403907.1 2130560 R 300267 CDS YP_403908.1 82777559 3795429 complement(2131607..2132353) 1 NC_007606.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 2132353 kdsB 3795429 kdsB Shigella dysenteriae Sd197 3-deoxy-manno-octulosonate cytidylyltransferase YP_403908.1 2131607 R 300267 CDS YP_403909.1 82777560 3795430 complement(2132350..2132532) 1 NC_007606.1 Code: S; COG: COG2835; hypothetical protein 2132532 ycaR 3795430 ycaR Shigella dysenteriae Sd197 hypothetical protein YP_403909.1 2132350 R 300267 CDS YP_403910.1 82777561 3795431 complement(2132584..2133816) 1 NC_007606.1 Code: S; COG: COG3214; hypothetical protein 2133816 ycaQ 3795431 ycaQ Shigella dysenteriae Sd197 hypothetical protein YP_403910.1 2132584 R 300267 CDS YP_403911.1 82777562 3795432 complement(2133853..2134839) 1 NC_007606.1 ''transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate''; tetraacyldisaccharide 4'-kinase 2134839 lpxK 3795432 lpxK Shigella dysenteriae Sd197 tetraacyldisaccharide 4'-kinase YP_403911.1 2133853 R 300267 CDS YP_403912.1 82777563 3795433 complement(2134836..2136584) 1 NC_007606.1 multicopy suppressor of htrB; involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 2136584 msbA 3795433 msbA Shigella dysenteriae Sd197 lipid transporter ATP-binding/permease YP_403912.1 2134836 R 300267 CDS YP_403913.2 161950089 3795434 complement(2136621..2138885) 1 NC_007606.1 Code: R; COG: COG0658; hypothetical protein 2138885 ycaI 3795434 ycaI Shigella dysenteriae Sd197 hypothetical protein YP_403913.2 2136621 R 300267 CDS YP_403914.1 82777565 3795435 complement(2139092..2139376) 1 NC_007606.1 IHF; site-specific recombination; ''This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control''; integration host factor subunit beta 2139376 ihfB 3795435 ihfB Shigella dysenteriae Sd197 integration host factor subunit beta YP_403914.1 2139092 R 300267 CDS YP_403915.1 82777566 3795436 complement(2139536..2141209) 1 NC_007606.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 2141209 rpsA 3795436 rpsA Shigella dysenteriae Sd197 30S ribosomal protein S1 YP_403915.1 2139536 R 300267 CDS YP_403916.1 82777567 3795437 complement(2141320..2142003) 1 NC_007606.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 2142003 cmk 3795437 cmk Shigella dysenteriae Sd197 cytidylate kinase YP_403916.1 2141320 R 300267 CDS YP_403917.1 82777568 3795438 complement(2142176..2142940) 1 NC_007606.1 Code: O; COG: COG0501; heat shock protein 2142940 ycaL 3795438 ycaL Shigella dysenteriae Sd197 heat shock protein YP_403917.1 2142176 R 300267 CDS YP_403918.1 82777569 3795439 2142994..2143404 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2143404 3795439 SDY_2350 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_403918.1 2142994 D 300267 CDS YP_403919.2 161950088 3795440 2143362..2144267 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2144267 3795440 SDY_2351 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_403919.2 2143362 D 300267 CDS YP_403920.1 82777571 3795441 2144465..2145811 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 2145811 3795441 SDY_2352 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_403920.1 2144465 D 300267 CDS YP_403921.1 82777572 3795442 complement(2145893..2147167) 1 NC_007606.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 2147167 aroA 3795442 aroA Shigella dysenteriae Sd197 3-phosphoshikimate 1-carboxyvinyltransferase YP_403921.1 2145893 R 300267 CDS YP_403922.1 82777573 3795443 complement(2147238..2148326) 1 NC_007606.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 2148326 serC 3795443 serC Shigella dysenteriae Sd197 phosphoserine aminotransferase YP_403922.1 2147238 R 300267 CDS YP_403923.1 82777574 3795444 complement(2148525..2149217) 1 NC_007606.1 Code: S; COG: COG2323; hypothetical protein 2149217 ycaP 3795444 ycaP Shigella dysenteriae Sd197 hypothetical protein YP_403923.1 2148525 R 300267 CDS YP_403925.1 82777576 3795965 2151514..2152371 1 NC_007606.1 formate channel 1; Code: P; COG: COG2116; formate transporter 2152371 focA 3795965 focA Shigella dysenteriae Sd197 formate transporter YP_403925.1 2151514 D 300267 CDS YP_403926.1 82777577 3795966 2152426..2154708 1 NC_007606.1 Code: C; COG: COG1882; formate acetyltransferase 1 2154708 pflB 3795966 pflB Shigella dysenteriae Sd197 formate acetyltransferase 1 YP_403926.1 2152426 D 300267 CDS YP_403927.1 82777578 3795967 2154900..2155640 1 NC_007606.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 2155640 pflA 3795967 pflA Shigella dysenteriae Sd197 pyruvate formate lyase-activating enzyme YP_403927.1 2154900 D 300267 CDS YP_009000779.1 578793247 18263093 2156213..2156485 1 NC_007606.1 insertion element iso-IS1N protein InsA 2156485 18263093 SDY_4706 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000779.1 2156213 D 300267 CDS YP_403928.2 161950087 3795968 2156512..2156907 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2156907 3795968 SDY_2360 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403928.2 2156512 D 300267 CDS YP_403929.1 82777580 3795969 complement(2158741..2159043) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2159043 3795969 SDY_2361 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403929.1 2158741 R 300267 CDS YP_403930.1 82777581 3795971 complement(2159533..2160681) 1 NC_007606.1 Code: GEPR; COG: COG0477; MFS family transporter protein 2160681 ycaD 3795971 ycaD Shigella dysenteriae Sd197 MFS family transporter protein YP_403930.1 2159533 R 300267 CDS YP_403932.1 82777583 3795973 complement(2161658..2162521) 1 NC_007606.1 Code: R; COG: COG3302; anaerobic dimethyl sulfoxide reductase subunit C 2162521 dmsC 3795973 dmsC Shigella dysenteriae Sd197 anaerobic dimethyl sulfoxide reductase subunit C YP_403932.1 2161658 R 300267 CDS YP_403933.1 82777584 3795975 complement(2163150..2165507) 1 NC_007606.1 Code: C; COG: COG0243; anaerobic dimethyl sulfoxide reductase subunit A 2165507 dmsA 3795975 dmsA Shigella dysenteriae Sd197 anaerobic dimethyl sulfoxide reductase subunit A YP_403933.1 2163150 R 300267 CDS YP_403934.1 82777585 3795976 complement(2165833..2167125) 1 NC_007606.1 ''catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; seryl-tRNA synthetase 2167125 serS 3795976 serS Shigella dysenteriae Sd197 seryl-tRNA synthetase YP_403934.1 2165833 R 300267 CDS YP_403935.1 82777586 3795977 complement(2167216..2168559) 1 NC_007606.1 Code: L; COG: COG2256; recombination factor protein RarA 2168559 ycaJ 3795977 ycaJ Shigella dysenteriae Sd197 recombination factor protein RarA YP_403935.1 2167216 R 300267 CDS YP_403936.1 82777587 3795978 complement(2168570..2169184) 1 NC_007606.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 2169184 lolA 3795978 lolA Shigella dysenteriae Sd197 outer-membrane lipoprotein carrier protein YP_403936.1 2168570 R 300267 CDS YP_403937.1 82777588 3795979 complement(2169336..2173442) 1 NC_007606.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 2173442 ftsK 3795979 ftsK Shigella dysenteriae Sd197 DNA translocase FtsK YP_403937.1 2169336 R 300267 CDS YP_403938.1 82777589 3795980 complement(2173577..2174071) 1 NC_007606.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 2174071 lrp 3795980 lrp Shigella dysenteriae Sd197 leucine-responsive transcriptional regulator YP_403938.1 2173577 R 300267 CDS YP_403939.1 82777590 3795981 2174616..2175581 1 NC_007606.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 2175581 trxB 3795981 trxB Shigella dysenteriae Sd197 thioredoxin reductase YP_403939.1 2174616 D 300267 CDS YP_403940.1 82777591 3795982 2175704..2177470 1 NC_007606.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2177470 cydD 3795982 cydD Shigella dysenteriae Sd197 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_403940.1 2175704 D 300267 CDS YP_403941.1 82777592 3798901 2177471..2179192 1 NC_007606.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 2179192 cydC 3798901 cydC Shigella dysenteriae Sd197 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_403941.1 2177471 D 300267 CDS YP_403942.1 82777593 3798902 2179234..2179938 1 NC_007606.1 ''leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys''; leucyl/phenylalanyl-tRNA--protein transferase 2179938 aat 3798902 aat Shigella dysenteriae Sd197 leucyl/phenylalanyl-tRNA--protein transferase YP_403942.1 2179234 D 300267 CDS YP_403943.1 82777594 3798903 2180223..2180441 1 NC_007606.1 ''stimulates the activities of the other two initiation factors, IF-2 and IF-3''; translation initiation factor IF-1 2180441 infA 3798903 infA Shigella dysenteriae Sd197 translation initiation factor IF-1 YP_403943.1 2180223 D 300267 CDS YP_403944.1 82777595 3798905 complement(2181125..2183401) 1 NC_007606.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 2183401 clpA 3798905 clpA Shigella dysenteriae Sd197 ATP-dependent Clp protease ATP-binding subunit YP_403944.1 2181125 R 300267 CDS YP_403945.1 82777596 3798906 complement(2183431..2183751) 1 NC_007606.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 2183751 clpS 3798906 clpS Shigella dysenteriae Sd197 ATP-dependent Clp protease adaptor protein ClpS YP_403945.1 2183431 R 300267 CDS YP_403946.1 82777597 3798907 2184074..2184298 1 NC_007606.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 2184298 cspD 3798907 cspD Shigella dysenteriae Sd197 stationary phase/starvation inducible regulatory protein CspD YP_403946.1 2184074 D 300267 CDS YP_403947.1 82777598 3798908 complement(2184371..2186323) 1 NC_007606.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 2186323 ybjZ 3798908 ybjZ Shigella dysenteriae Sd197 macrolide transporter ATP-binding /permease YP_403947.1 2184371 R 300267 CDS YP_403948.2 161950086 3798909 complement(2186320..2187369) 1 NC_007606.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 2187369 3798909 SDY_2383 Shigella dysenteriae Sd197 macrolide transporter subunit MacA YP_403948.2 2186320 R 300267 CDS YP_403949.1 82777600 3798910 2187484..2188476 1 NC_007606.1 Code: S; COG: COG2990; hypothetical protein 2188476 ybjX 3798910 ybjX Shigella dysenteriae Sd197 hypothetical protein YP_403949.1 2187484 D 300267 CDS YP_403950.1 82777601 3798911 complement(2188473..2190131) 1 NC_007606.1 Code: L; COG: COG3593; hypothetical protein 2190131 ybjD 3798911 ybjD Shigella dysenteriae Sd197 hypothetical protein YP_403950.1 2188473 R 300267 CDS YP_403951.1 82777602 3798912 complement(2190304..2190681) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2190681 insB 3798912 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_403951.1 2190304 R 300267 CDS YP_403952.1 82777603 3798913 complement(2190726..2191001) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2191001 insA 3798913 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_403952.1 2190726 R 300267 CDS YP_403953.1 82777604 3798914 2191334..2192011 1 NC_007606.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 2192011 aqpZ 3798914 aqpZ Shigella dysenteriae Sd197 aquaporin Z YP_403953.1 2191334 D 300267 CDS YP_403954.1 82777605 3798915 2192145..2193044 1 NC_007606.1 Code: S; COG: COG2431; surface protein 2193044 ybjE 3798915 ybjE Shigella dysenteriae Sd197 surface protein YP_403954.1 2192145 D 300267 CDS YP_403955.2 161950085 3798916 2193188..2194840 1 NC_007606.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 2194840 ybjW 3798916 ybjW Shigella dysenteriae Sd197 hydroxylamine reductase YP_403955.2 2193188 D 300267 CDS YP_403956.1 82777607 3798917 2194852..2195820 1 NC_007606.1 Code: C; COG: COG1018; HCP oxidoreductase 2195820 3798917 SDY_2391 Shigella dysenteriae Sd197 HCP oxidoreductase YP_403956.1 2194852 D 300267 CDS YP_403957.1 82777608 3798918 2195953..2197671 1 NC_007606.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 2197671 poxB 3798918 poxB Shigella dysenteriae Sd197 pyruvate dehydrogenase YP_403957.1 2195953 D 300267 CDS YP_403958.1 82777609 3798919 2197708..2198709 1 NC_007606.1 ''low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine''; L-threonine aldolase 2198709 ybjU 3798919 ybjU Shigella dysenteriae Sd197 L-threonine aldolase YP_403958.1 2197708 D 300267 CDS YP_403959.1 82777610 3797969 2198720..2200150 1 NC_007606.1 Code: MG; COG: COG0702; dTDP-glucose enzyme 2200150 ybjT 3797969 ybjT Shigella dysenteriae Sd197 dTDP-glucose enzyme YP_403959.1 2198720 D 300267 CDS YP_403960.1 82777611 3797970 2200213..2201262 1 NC_007606.1 Code: MG; COG: COG0451; nucleotide di-P-sugar epimerase or dehydratase 2201262 3797970 SDY_2395 Shigella dysenteriae Sd197 nucleotide di-P-sugar epimerase or dehydratase YP_403960.1 2200213 D 300267 CDS YP_403961.1 82777612 3797971 complement(2201259..2202089) 1 NC_007606.1 Code: V; COG: COG3023; regulator 2202089 3797971 SDY_2396 Shigella dysenteriae Sd197 regulator YP_403961.1 2201259 R 300267 CDS YP_403962.1 82777613 3797972 complement(2202086..2202409) 1 NC_007606.1 Code: S; COG: COG0393; hypothetical protein 2202409 3797972 SDY_2397 Shigella dysenteriae Sd197 hypothetical protein YP_403962.1 2202086 R 300267 CDS YP_403963.1 82777614 3797973 2203083..2203358 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2203358 insA 3797973 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_403963.1 2203083 D 300267 CDS YP_009000780.1 578793248 18263094 2203403..2203780 1 NC_007606.1 transposase IS1 2203780 18263094 SDY_2398a Shigella dysenteriae Sd197 transposase IS1 YP_009000780.1 2203403 D 300267 CDS YP_403965.1 82777616 3797975 complement(2204333..2204728) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2204728 3797975 SDY_2400 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_403965.1 2204333 R 300267 CDS YP_009000781.1 578793249 18263095 complement(2204755..2205027) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2205027 18263095 SDY_4707 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000781.1 2204755 R 300267 CDS YP_403966.1 82777617 3797976 complement(2205067..2205846) 1 NC_007606.1 hypothetical protein 2205846 3797976 SDY_2401 Shigella dysenteriae Sd197 hypothetical protein YP_403966.1 2205067 R 300267 CDS YP_009000782.1 578793250 18263096 2206170..2206442 1 NC_007606.1 insertion element iso-IS1N protein InsA 2206442 18263096 SDY_4708 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000782.1 2206170 D 300267 CDS YP_403967.1 82777618 3797977 2206469..2206864 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2206864 3797977 SDY_2402 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_403967.1 2206469 D 300267 CDS YP_403969.1 82777620 3797979 2208003..2208731 1 NC_007606.1 With ArtMQJI transports arginine across the inner membrane; arginine ABC transporter ATP-binding protein 2208731 artP 3797979 artP Shigella dysenteriae Sd197 arginine ABC transporter ATP-binding protein YP_403969.1 2208003 D 300267 CDS YP_403970.1 82777621 3797980 2208749..2209480 1 NC_007606.1 Code: ET; COG: COG0834; arginine ABC transporter substrate-binding protein 2209480 artI 3797980 artI Shigella dysenteriae Sd197 arginine ABC transporter substrate-binding protein YP_403970.1 2208749 D 300267 CDS YP_403971.1 82777622 3797981 2209487..2210203 1 NC_007606.1 with ArtPMJI transports arginine across the inner membrane; arginine ABC transporter permease ArtQ 2210203 artQ 3797981 artQ Shigella dysenteriae Sd197 arginine ABC transporter permease ArtQ YP_403971.1 2209487 D 300267 CDS YP_403972.1 82777623 3797982 2210203..2210871 1 NC_007606.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine ABC transporter permease ArtM 2210871 artM 3797982 artM Shigella dysenteriae Sd197 arginine ABC transporter permease ArtM YP_403972.1 2210203 D 300267 CDS YP_403974.1 82777625 3797985 complement(2211710..2212519) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2212519 3797985 SDY_2410 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_403974.1 2211710 R 300267 CDS YP_403975.1 82777626 3797986 complement(2212660..2212962) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2212962 3797986 SDY_2411 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403975.1 2212660 R 300267 CDS YP_009000783.1 578793251 18263097 complement(2213189..2213461) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2213461 18263097 SDY_4709 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000783.1 2213189 R 300267 CDS YP_403978.1 82777629 3797408 complement(2213696..2214424) 1 NC_007606.1 Code: S; COG: COG3645; DNA-binding protein Roi of bacteriophage BP-933W 2214424 3797408 SDY_2414 Shigella dysenteriae Sd197 DNA-binding protein Roi of bacteriophage BP-933W YP_403978.1 2213696 R 300267 CDS YP_403979.2 578793252 3797409 complement(2214493..2215170) 1 NC_007606.1 Code: K; COG: COG3561; antirepressor protein 2215170 3797409 SDY_2415 Shigella dysenteriae Sd197 antirepressor protein YP_403979.2 2214493 R 300267 CDS YP_403980.1 82777631 3797410 2215810..2216118 1 NC_007606.1 hypothetical protein 2216118 3797410 SDY_2416 Shigella dysenteriae Sd197 hypothetical protein YP_403980.1 2215810 D 300267 CDS YP_403981.1 82777632 3797411 complement(2216333..2216743) 1 NC_007606.1 recombination protein 2216743 ninB 3797411 ninB Shigella dysenteriae Sd197 recombination protein YP_403981.1 2216333 R 300267 CDS YP_403982.1 82777633 3797412 complement(2216796..2217584) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2217584 3797412 SDY_2418 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_403982.1 2216796 R 300267 CDS YP_403983.1 82777634 3797413 complement(2217725..2218027) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2218027 3797413 SDY_2419 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_403983.1 2217725 R 300267 CDS YP_403984.1 82777635 3797414 2218110..2219165 1 NC_007606.1 Code: L; COG: COG0582; integrase 2219165 3797414 SDY_2420 Shigella dysenteriae Sd197 integrase YP_403984.1 2218110 D 300267 CDS YP_403985.1 82777636 3797415 complement(2219223..2219783) 1 NC_007606.1 Code: S; COG: COG3234; hypothetical protein 2219783 3797415 SDY_2421 Shigella dysenteriae Sd197 hypothetical protein YP_403985.1 2219223 R 300267 CDS YP_403986.1 82777637 3797416 complement(2219780..2220256) 1 NC_007606.1 hypothetical protein 2220256 3797416 SDY_2422 Shigella dysenteriae Sd197 hypothetical protein YP_403986.1 2219780 R 300267 CDS YP_403987.1 82777638 3797417 complement(2220357..2222984) 1 NC_007606.1 type II topoisomerase; negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2222984 gyrA 3797417 gyrA Shigella dysenteriae Sd197 DNA gyrase subunit A YP_403987.1 2220357 R 300267 CDS YP_403988.1 82777639 3797418 2223131..2223853 1 NC_007606.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2223853 ubiG 3797418 ubiG Shigella dysenteriae Sd197 3-demethylubiquinone-9 3-methyltransferase YP_403988.1 2223131 D 300267 CDS YP_403992.1 82777643 3797422 2228442..2230727 1 NC_007606.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2230727 nrdA 3797422 nrdA Shigella dysenteriae Sd197 ribonucleotide-diphosphate reductase subunit alpha YP_403992.1 2228442 D 300267 CDS YP_403993.1 82777644 3797423 2230873..2232003 1 NC_007606.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2232003 nrdB 3797423 nrdB Shigella dysenteriae Sd197 ribonucleotide-diphosphate reductase subunit beta YP_403993.1 2230873 D 300267 CDS YP_403994.1 82777645 3797424 2232003..2232257 1 NC_007606.1 ''plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases''; 2Fe-2S ferredoxin 2232257 yfaE 3797424 yfaE Shigella dysenteriae Sd197 2Fe-2S ferredoxin YP_403994.1 2232003 D 300267 CDS YP_403996.1 82777647 3797426 complement(2233042..2234232) 1 NC_007606.1 Code: GEPR; COG: COG0477; antibiotic resistance protein 2234232 3797426 SDY_2432 Shigella dysenteriae Sd197 antibiotic resistance protein YP_403996.1 2233042 R 300267 CDS YP_403998.1 82777649 3798235 complement(2235313..2236392) 1 NC_007606.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2236392 glpQ 3798235 glpQ Shigella dysenteriae Sd197 glycerophosphodiester phosphodiesterase YP_403998.1 2235313 R 300267 CDS YP_403999.1 82777650 3798236 complement(2236397..2237755) 1 NC_007606.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2237755 glpT 3798236 glpT Shigella dysenteriae Sd197 sn-glycerol-3-phosphate transporter YP_403999.1 2236397 R 300267 CDS YP_404000.1 82777651 3798237 2238028..2239656 1 NC_007606.1 ''anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor''; sn-glycerol-3-phosphate dehydrogenase subunit A 2239656 glpA 3798237 glpA Shigella dysenteriae Sd197 sn-glycerol-3-phosphate dehydrogenase subunit A YP_404000.1 2238028 D 300267 CDS YP_404001.1 82777652 3798238 2239646..2240905 1 NC_007606.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2240905 glpB 3798238 glpB Shigella dysenteriae Sd197 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_404001.1 2239646 D 300267 CDS YP_404002.1 82777653 3798239 2240902..2242092 1 NC_007606.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2242092 glpC 3798239 glpC Shigella dysenteriae Sd197 sn-glycerol-3-phosphate dehydrogenase subunit C YP_404002.1 2240902 D 300267 CDS YP_404003.1 82777654 3798240 2242285..2243211 1 NC_007606.1 Code: S; COG: COG5464; hypothetical protein 2243211 yfaD 3798240 yfaD Shigella dysenteriae Sd197 hypothetical protein YP_404003.1 2242285 D 300267 CDS YP_404004.1 82777655 3798241 complement(2243252..2244055) 1 NC_007606.1 Code: G; COG: COG3836; aldolase 2244055 3798241 SDY_2440 Shigella dysenteriae Sd197 aldolase YP_404004.1 2243252 R 300267 CDS YP_009000784.1 578793253 18263098 2245207..2245482 1 NC_007606.1 transposase IS1 2245482 18263098 SDY_2440a Shigella dysenteriae Sd197 transposase IS1 YP_009000784.1 2245207 D 300267 CDS YP_404005.1 82777656 3798243 2245527..2245904 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2245904 insB 3798243 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404005.1 2245527 D 300267 CDS YP_404007.1 82777658 3798246 complement(2247649..2247924) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2247924 insA 3798246 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404007.1 2247649 R 300267 CDS YP_404010.1 82777661 3798249 2249008..2249403 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2249403 3798249 SDY_2448 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404010.1 2249008 D 300267 CDS YP_404011.1 82777662 3798250 2249487..2250014 1 NC_007606.1 hypothetical protein 2250014 3798250 SDY_2449 Shigella dysenteriae Sd197 hypothetical protein YP_404011.1 2249487 D 300267 CDS YP_404014.1 82777665 3797275 2252964..2253854 1 NC_007606.1 Code: G; COG: COG0726; hypothetical protein 2253854 3797275 SDY_2452 Shigella dysenteriae Sd197 hypothetical protein YP_404014.1 2252964 D 300267 CDS YP_404015.1 82777666 3797276 2253854..2255506 1 NC_007606.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2255506 arnT 3797276 arnT Shigella dysenteriae Sd197 4-amino-4-deoxy-L-arabinose transferase YP_404015.1 2253854 D 300267 CDS YP_404016.2 161950084 3797277 2255838..2256224 1 NC_007606.1 Code: GER; COG: COG0697; hypothetical protein 2256224 3797277 SDY_2454 Shigella dysenteriae Sd197 hypothetical protein YP_404016.2 2255838 D 300267 CDS YP_404017.1 82777668 3797278 complement(2256252..2256512) 1 NC_007606.1 polymyxin resistance protein B 2256512 pmrD 3797278 pmrD Shigella dysenteriae Sd197 polymyxin resistance protein B YP_404017.1 2256252 R 300267 CDS YP_404018.1 82777669 3797279 complement(2256592..2257947) 1 NC_007606.1 Code: IQ; COG: COG0318; O-succinylbenzoic acid--CoA ligase 2257947 menE 3797279 menE Shigella dysenteriae Sd197 O-succinylbenzoic acid--CoA ligase YP_404018.1 2256592 R 300267 CDS YP_404019.1 82777670 3797280 complement(2257944..2258906) 1 NC_007606.1 conversion of chorismate to 2-o-succinylbenzoyl-CoA; ''catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate''; O-succinylbenzoate synthase 2258906 menC 3797280 menC Shigella dysenteriae Sd197 O-succinylbenzoate synthase YP_404019.1 2257944 R 300267 CDS YP_404020.1 82777671 3797281 complement(2258906..2259763) 1 NC_007606.1 ''catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA''; naphthoate synthase 2259763 menB 3797281 menB Shigella dysenteriae Sd197 naphthoate synthase YP_404020.1 2258906 R 300267 CDS YP_404021.1 82777672 3797282 complement(2259778..2260536) 1 NC_007606.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase 2260536 yfbB 3797282 yfbB Shigella dysenteriae Sd197 acyl-CoA thioester hydrolase YP_404021.1 2259778 R 300267 CDS YP_404022.1 82777673 3797283 complement(2260533..2262203) 1 NC_007606.1 SHCHC synthase; SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2262203 menD 3797283 menD Shigella dysenteriae Sd197 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_404022.1 2260533 R 300267 CDS YP_404023.2 161950083 3797284 complement(2262292..2263587) 1 NC_007606.1 Code: HQ; COG: COG1169; isochorismate hydroxymutase 2263587 menF 3797284 menF Shigella dysenteriae Sd197 isochorismate hydroxymutase YP_404023.2 2262292 R 300267 CDS YP_404024.1 82777675 3797285 complement(2263666..2263971) 1 NC_007606.1 Code: S; COG: COG4575; hypothetical protein 2263971 elaB 3797285 elaB Shigella dysenteriae Sd197 hypothetical protein YP_404024.1 2263666 R 300267 CDS YP_404025.1 82777676 3797286 complement(2264026..2264487) 1 NC_007606.1 Code: R; COG: COG2153; hypothetical protein 2264487 elaA 3797286 elaA Shigella dysenteriae Sd197 hypothetical protein YP_404025.1 2264026 R 300267 CDS YP_404026.2 161950082 3797287 2264552..2265469 1 NC_007606.1 member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2265469 elaC 3797287 elaC Shigella dysenteriae Sd197 ribonuclease Z YP_404026.2 2264552 D 300267 CDS YP_404027.1 82777678 3797289 2266277..2266552 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2266552 insA 3797289 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404027.1 2266277 D 300267 CDS YP_404028.1 82777679 3797290 2266597..2266974 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2266974 insB 3797290 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404028.1 2266597 D 300267 CDS YP_009000785.1 578793254 18263099 complement(2267333..2267605) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2267605 18263099 SDY_4710 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000785.1 2267333 R 300267 CDS YP_009000786.1 578793255 18263100 2268084..2268356 1 NC_007606.1 insertion element iso-IS1N protein InsA 2268356 18263100 SDY_4711 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000786.1 2268084 D 300267 CDS YP_404030.1 82777681 3797292 2268383..2268778 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2268778 3797292 SDY_2469 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404030.1 2268383 D 300267 CDS YP_404032.1 82777683 3797294 2269166..2269669 1 NC_007606.1 hypothetical protein 2269669 yfbM 3797294 yfbM Shigella dysenteriae Sd197 hypothetical protein YP_404032.1 2269166 D 300267 CDS YP_404033.2 161950081 3797592 complement(2269736..2271193) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2271193 nuoN 3797592 nuoN Shigella dysenteriae Sd197 NADH dehydrogenase subunit N YP_404033.2 2269736 R 300267 CDS YP_404034.1 82777685 3797593 complement(2271200..2272729) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2272729 nuoM 3797593 nuoM Shigella dysenteriae Sd197 NADH dehydrogenase subunit M YP_404034.1 2271200 R 300267 CDS YP_404035.1 82777686 3797594 complement(2272960..2274801) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2274801 nuoL 3797594 nuoL Shigella dysenteriae Sd197 NADH dehydrogenase subunit L YP_404035.1 2272960 R 300267 CDS YP_404036.1 82777687 3797595 complement(2274798..2275100) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2275100 nuoK 3797595 nuoK Shigella dysenteriae Sd197 NADH dehydrogenase subunit K YP_404036.1 2274798 R 300267 CDS YP_404037.1 82777688 3797596 complement(2275097..2275651) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2275651 nuoJ 3797596 nuoJ Shigella dysenteriae Sd197 NADH dehydrogenase subunit J YP_404037.1 2275097 R 300267 CDS YP_404038.1 82777689 3797597 complement(2275663..2276205) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2276205 nuoI 3797597 nuoI Shigella dysenteriae Sd197 NADH dehydrogenase subunit I YP_404038.1 2275663 R 300267 CDS YP_404039.1 82777690 3797598 complement(2276220..2277197) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2277197 nuoH 3797598 nuoH Shigella dysenteriae Sd197 NADH dehydrogenase subunit H YP_404039.1 2276220 R 300267 CDS YP_404040.1 82777691 3797599 complement(2277194..2279926) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2279926 nuoG 3797599 nuoG Shigella dysenteriae Sd197 NADH dehydrogenase subunit G YP_404040.1 2277194 R 300267 CDS YP_404041.1 82777692 3797600 complement(2279973..2281310) 1 NC_007606.1 ''shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase''; NADH dehydrogenase I subunit F 2281310 nuoF 3797600 nuoF Shigella dysenteriae Sd197 NADH dehydrogenase I subunit F YP_404041.1 2279973 R 300267 CDS YP_404042.1 82777693 3797601 complement(2281307..2281807) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2281807 nuoE 3797601 nuoE Shigella dysenteriae Sd197 NADH dehydrogenase subunit E YP_404042.1 2281307 R 300267 CDS YP_404043.1 82777694 3797602 complement(2281810..2283612) 1 NC_007606.1 ''NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms''; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2283612 nuoC 3797602 nuoC Shigella dysenteriae Sd197 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_404043.1 2281810 R 300267 CDS YP_404044.1 82777695 3797603 complement(2283706..2284368) 1 NC_007606.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2284368 nuoB 3797603 nuoB Shigella dysenteriae Sd197 NADH dehydrogenase subunit B YP_404044.1 2283706 R 300267 CDS YP_404045.1 82777696 3797604 complement(2284384..2284827) 1 NC_007606.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2284827 nuoA 3797604 nuoA Shigella dysenteriae Sd197 NADH dehydrogenase subunit A YP_404045.1 2284384 R 300267 CDS YP_404046.1 82777697 3797605 complement(2285459..2286397) 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2286397 lrhA 3797605 lrhA Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_404046.1 2285459 R 300267 CDS YP_404047.1 82777698 3797606 2287311..2288528 1 NC_007606.1 ''broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor''; aminotransferase 2288528 3797606 SDY_2486 Shigella dysenteriae Sd197 aminotransferase YP_404047.1 2287311 D 300267 CDS YP_404048.1 82777699 3797607 2288612..2289211 1 NC_007606.1 Code: R; COG: COG1896; hypothetical protein 2289211 3797607 SDY_2487 Shigella dysenteriae Sd197 hypothetical protein YP_404048.1 2288612 D 300267 CDS YP_404049.1 82777700 3797608 complement(2289270..2291102) 1 NC_007606.1 Code: P; COG: COG0471; transport protein 2291102 yfbS 3797608 yfbS Shigella dysenteriae Sd197 transport protein YP_404049.1 2289270 R 300267 CDS YP_404050.1 82777701 3797609 complement(2291189..2291839) 1 NC_007606.1 Code: R; COG: COG0637; phosphatase 2291839 yfbT 3797609 yfbT Shigella dysenteriae Sd197 phosphatase YP_404050.1 2291189 R 300267 CDS YP_404051.2 161950080 3797610 complement(2291850..2292344) 1 NC_007606.1 Code: S; COG: COG3013; hypothetical protein 2292344 3797610 SDY_2490 Shigella dysenteriae Sd197 hypothetical protein YP_404051.2 2291850 R 300267 CDS YP_404052.1 82777703 3799537 complement(2292427..2292882) 1 NC_007606.1 Code: S; COG: COG3092; hypothetical protein 2292882 3799537 SDY_2491 Shigella dysenteriae Sd197 hypothetical protein YP_404052.1 2292427 R 300267 CDS YP_404053.1 82777704 3799538 2293220..2294422 1 NC_007606.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2294422 ackA 3799538 ackA Shigella dysenteriae Sd197 acetate kinase YP_404053.1 2293220 D 300267 CDS YP_404054.1 82777705 3799539 2294497..2296641 1 NC_007606.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2296641 pta 3799539 pta Shigella dysenteriae Sd197 phosphate acetyltransferase YP_404054.1 2294497 D 300267 CDS YP_404055.2 161950079 3799540 2296831..2298351 1 NC_007606.1 Code: S; COG: COG1288; hypothetical protein 2298351 yfcC 3799540 yfcC Shigella dysenteriae Sd197 hypothetical protein YP_404055.2 2296831 D 300267 CDS YP_404056.1 82777707 3799541 complement(2298384..2298926) 1 NC_007606.1 Code: LR; COG: COG0494; regulator 2298926 3799541 SDY_2495 Shigella dysenteriae Sd197 regulator YP_404056.1 2298384 R 300267 CDS YP_404057.1 82777708 3799542 complement(2298984..2299538) 1 NC_007606.1 Code: R; COG: COG0622; phosphodiesterase 2299538 yfcE 3799542 yfcE Shigella dysenteriae Sd197 phosphodiesterase YP_404057.1 2298984 R 300267 CDS YP_404060.1 82777711 3799545 2300371..2301018 1 NC_007606.1 Code: O; COG: COG0625; glutathione S-transferase 2301018 yfcG 3799545 yfcG Shigella dysenteriae Sd197 glutathione S-transferase YP_404060.1 2300371 D 300267 CDS YP_404061.1 82777712 3799546 2301075..2301437 1 NC_007606.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2301437 folX 3799546 folX Shigella dysenteriae Sd197 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_404061.1 2301075 D 300267 CDS YP_404062.1 82777713 3799547 2301458..2302351 1 NC_007606.1 Code: R; COG: COG1090; sugar nucleotide epimerase 2302351 3799547 SDY_2501 Shigella dysenteriae Sd197 sugar nucleotide epimerase YP_404062.1 2301458 D 300267 CDS YP_404063.1 82777714 3799548 complement(2302399..2303019) 1 NC_007606.1 Code: S; COG: COG5464; hypothetical protein 2303019 yfcI 3799548 yfcI Shigella dysenteriae Sd197 hypothetical protein YP_404063.1 2302399 R 300267 CDS YP_404066.1 82777717 3799551 complement(2304242..2305015) 1 NC_007606.1 Code: E; COG: COG4598; histidine/lysine/arginine/ornithine transporter protein 2305015 hisP 3799551 hisP Shigella dysenteriae Sd197 histidine/lysine/arginine/ornithine transporter protein YP_404066.1 2304242 R 300267 CDS YP_404067.1 82777718 3799552 complement(2305023..2305739) 1 NC_007606.1 Code: E; COG: COG4160; histidine transport system protein M 2305739 hisM 3799552 hisM Shigella dysenteriae Sd197 histidine transport system protein M YP_404067.1 2305023 R 300267 CDS YP_404068.1 82777719 3799553 complement(2305736..2306422) 1 NC_007606.1 Code: E; COG: COG4215; histidine transport system permease 2306422 hisQ 3799553 hisQ Shigella dysenteriae Sd197 histidine transport system permease YP_404068.1 2305736 R 300267 CDS YP_404069.1 82777720 3799554 complement(2306512..2307294) 1 NC_007606.1 Code: ET; COG: COG0834; high-affinity histidine transport system substrate-binding protein 2307294 hisJ 3799554 hisJ Shigella dysenteriae Sd197 high-affinity histidine transport system substrate-binding protein YP_404069.1 2306512 R 300267 CDS YP_404070.1 82777721 3799555 complement(2307515..2308297) 1 NC_007606.1 Code: ET; COG: COG0834; lysine-, arginine-, ornithine-binding periplasmic protein 2308297 argT 3799555 argT Shigella dysenteriae Sd197 lysine-, arginine-, ornithine-binding periplasmic protein YP_404070.1 2307515 R 300267 CDS YP_404071.1 82777722 3799556 complement(2308562..2309131) 1 NC_007606.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2309131 ubiX 3799556 ubiX Shigella dysenteriae Sd197 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_404071.1 2308562 R 300267 CDS YP_404072.1 82777723 3797651 complement(2309226..2310743) 1 NC_007606.1 PRPP amidotransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2310743 purF 3797651 purF Shigella dysenteriae Sd197 amidophosphoribosyltransferase YP_404072.1 2309226 R 300267 CDS YP_404073.1 82777724 3797652 complement(2310780..2311268) 1 NC_007606.1 membrane protein required for colicin V production; colicin V production protein 2311268 cvpA 3797652 cvpA Shigella dysenteriae Sd197 colicin V production protein YP_404073.1 2310780 R 300267 CDS YP_404074.2 161950078 3797653 complement(2311709..2312371) 1 NC_007606.1 Code: S; COG: COG3147; hypothetical protein 2312371 dedD 3797653 dedD Shigella dysenteriae Sd197 hypothetical protein YP_404074.2 2311709 R 300267 CDS YP_404075.1 82777726 3797654 complement(2312361..2313629) 1 NC_007606.1 dihydrofolate synthetase; Code: H; COG: COG0285; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2313629 folC 3797654 folC Shigella dysenteriae Sd197 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_404075.1 2312361 R 300267 CDS YP_404076.1 82777727 3797655 complement(2313699..2314613) 1 NC_007606.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2314613 accD 3797655 accD Shigella dysenteriae Sd197 acetyl-CoA carboxylase subunit beta YP_404076.1 2313699 R 300267 CDS YP_404077.1 82777728 3797656 complement(2314769..2315428) 1 NC_007606.1 Code: S; COG: COG0586; hypothetical protein 2315428 dedA 3797656 dedA Shigella dysenteriae Sd197 hypothetical protein YP_404077.1 2314769 R 300267 CDS YP_404078.1 82777729 3797657 complement(2315511..2316323) 1 NC_007606.1 ''mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability''; tRNA pseudouridine synthase A 2316323 truA 3797657 truA Shigella dysenteriae Sd197 tRNA pseudouridine synthase A YP_404078.1 2315511 R 300267 CDS YP_404079.1 82777730 3797658 complement(2316323..2317336) 1 NC_007606.1 Code: E; COG: COG0136; semialdehyde dehydrogenase 2317336 usg 3797658 usg Shigella dysenteriae Sd197 semialdehyde dehydrogenase YP_404079.1 2316323 R 300267 CDS YP_404080.1 82777731 3797659 complement(2317402..2318538) 1 NC_007606.1 Code: HE; COG: COG0111; erythronate-4-phosphate dehydrogenase 2318538 pdxB 3797659 pdxB Shigella dysenteriae Sd197 erythronate-4-phosphate dehydrogenase YP_404080.1 2317402 R 300267 CDS YP_404081.1 82777732 3797660 2318637..2319632 1 NC_007606.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2319632 flk 3797660 flk Shigella dysenteriae Sd197 flagella biosynthesis regulator YP_404081.1 2318637 D 300267 CDS YP_404082.1 82777733 3797661 complement(2319629..2320081) 1 NC_007606.1 hypothetical protein 2320081 3797661 SDY_2521 Shigella dysenteriae Sd197 hypothetical protein YP_404082.1 2319629 R 300267 CDS YP_404083.1 82777734 3797662 complement(2320477..2321697) 1 NC_007606.1 ''FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''; 3-oxoacyl-ACP synthase 2321697 fabB 3797662 fabB Shigella dysenteriae Sd197 3-oxoacyl-ACP synthase YP_404083.1 2320477 R 300267 CDS YP_404084.2 161950077 3797663 2321856..2323862 1 NC_007606.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2323862 mnmC 3797663 mnmC Shigella dysenteriae Sd197 5-methylaminomethyl-2-thiouridine methyltransferase YP_404084.2 2321856 D 300267 CDS YP_404085.1 82777736 3797664 complement(2323983..2324261) 1 NC_007606.1 hypothetical protein 2324261 3797664 SDY_2524 Shigella dysenteriae Sd197 hypothetical protein YP_404085.1 2323983 R 300267 CDS YP_404086.1 82777737 3797665 complement(2324295..2324843) 1 NC_007606.1 Code: S; COG: COG3101; transporting ATPase 2324843 3797665 SDY_2525 Shigella dysenteriae Sd197 transporting ATPase YP_404086.1 2324295 R 300267 CDS YP_404087.1 82777738 3797667 complement(2325652..2326476) 1 NC_007606.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2326476 mepA 3797667 mepA Shigella dysenteriae Sd197 penicillin-insensitive murein endopeptidase YP_404087.1 2325652 R 300267 CDS YP_404088.1 82777739 3797668 complement(2326480..2327565) 1 NC_007606.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2327565 aroC 3797668 aroC Shigella dysenteriae Sd197 chorismate synthase YP_404088.1 2326480 R 300267 CDS YP_404089.2 578793256 3797631 complement(2327600..2328532) 1 NC_007606.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2328532 3797631 SDY_2530 Shigella dysenteriae Sd197 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_404089.2 2327600 R 300267 CDS YP_404090.1 82777740 3797669 2328698..2329249 1 NC_007606.1 Code: S; COG: COG2840; hypothetical protein 2329249 3797669 SDY_2529 Shigella dysenteriae Sd197 hypothetical protein YP_404090.1 2328698 D 300267 CDS YP_404092.1 82777743 3797633 complement(2330258..2330797) 1 NC_007606.1 Code: NU; COG: COG3539; fimbrial-like protein 2330797 3797633 SDY_2532 Shigella dysenteriae Sd197 fimbrial-like protein YP_404092.1 2330258 R 300267 CDS YP_404093.1 82777744 3797634 complement(2330794..2331282) 1 NC_007606.1 Code: NU; COG: COG3539; hypothetical protein 2331282 3797634 SDY_2533 Shigella dysenteriae Sd197 hypothetical protein YP_404093.1 2330794 R 300267 CDS YP_404094.1 82777745 3797635 complement(2331279..2331785) 1 NC_007606.1 Code: NU; COG: COG3539; fimbrial protein 2331785 3797635 SDY_2534 Shigella dysenteriae Sd197 fimbrial protein YP_404094.1 2331279 R 300267 CDS YP_404095.1 82777746 3797636 complement(2331801..2332550) 1 NC_007606.1 Code: NU; COG: COG3121; chaperone 2332550 yfcS 3797636 yfcS Shigella dysenteriae Sd197 chaperone YP_404095.1 2331801 R 300267 CDS YP_404099.1 82777750 3797640 complement(2336242..2336619) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2336619 insB 3797640 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404099.1 2336242 R 300267 CDS YP_404100.1 82777751 3797641 complement(2336664..2336939) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2336939 insA 3797641 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404100.1 2336664 R 300267 CDS YP_404101.1 82777752 3797642 complement(2337298..2337783) 1 NC_007606.1 Code: T; COG: COG2062; phosphohistidine phosphatase 2337783 3797642 SDY_2541 Shigella dysenteriae Sd197 phosphohistidine phosphatase YP_404101.1 2337298 R 300267 CDS YP_404102.1 82777753 3797643 complement(2337986..2340130) 1 NC_007606.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2340130 fadJ 3797643 fadJ Shigella dysenteriae Sd197 multifunctional fatty acid oxidation complex subunit alpha YP_404102.1 2337986 R 300267 CDS YP_404103.1 82777754 3797644 complement(2340130..2341440) 1 NC_007606.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2341440 fadI 3797644 fadI Shigella dysenteriae Sd197 3-ketoacyl-CoA thiolase YP_404103.1 2340130 R 300267 CDS YP_404104.1 82777755 3797645 complement(2341621..2341929) 1 NC_007606.1 Code: S; COG: COG3691; hypothetical protein 2341929 3797645 SDY_2544 Shigella dysenteriae Sd197 hypothetical protein YP_404104.1 2341621 R 300267 CDS YP_404105.1 82777756 3797646 2342270..2343616 1 NC_007606.1 transport of long-chain fatty acids; sensitivity to phage T2; Code: I; COG: COG2067; long-chain fatty acid outer membrane transporter 2343616 fadL 3797646 fadL Shigella dysenteriae Sd197 long-chain fatty acid outer membrane transporter YP_404105.1 2342270 D 300267 CDS YP_009000787.1 578793257 18263101 2343883..2344155 1 NC_007606.1 insertion element iso-IS1N protein InsA 2344155 18263101 SDY_4712 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000787.1 2343883 D 300267 CDS YP_404108.1 82777759 3797649 complement(2344556..2344933) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2344933 insB 3797649 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404108.1 2344556 R 300267 CDS YP_404109.1 82777760 3797650 complement(2344978..2345253) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2345253 insA 3797650 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404109.1 2344978 R 300267 CDS YP_404110.1 82777761 3795635 complement(2346527..2347282) 1 NC_007606.1 Code: M; COG: COG2853; lipoprotein 2347282 vacJ 3795635 vacJ Shigella dysenteriae Sd197 lipoprotein YP_404110.1 2346527 R 300267 CDS YP_404111.1 82777762 3795636 2347575..2348507 1 NC_007606.1 Code: P; COG: COG2116; transporter 2348507 yfdC 3795636 yfdC Shigella dysenteriae Sd197 transporter YP_404111.1 2347575 D 300267 CDS YP_404112.1 82777763 3795638 complement(2349124..2349501) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2349501 insB 3795638 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404112.1 2349124 R 300267 CDS YP_404113.1 82777764 3795639 complement(2349546..2349821) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2349821 insA 3795639 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404113.1 2349546 R 300267 CDS YP_404114.1 82777765 3795640 2350792..2351187 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2351187 3795640 SDY_2555 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404114.1 2350792 D 300267 CDS YP_404115.1 82777766 3795643 2353098..2354531 1 NC_007606.1 Code: G; COG: COG1621; sucrose hydrolase 2354531 3795643 SDY_2558 Shigella dysenteriae Sd197 sucrose hydrolase YP_404115.1 2353098 D 300267 CDS YP_404116.1 82777767 3795644 complement(2354539..2355534) 1 NC_007606.1 Code: K; COG: COG1609; sucrose operon repressor 2355534 3795644 SDY_2559 Shigella dysenteriae Sd197 sucrose operon repressor YP_404116.1 2354539 R 300267 CDS YP_404117.1 82777768 3795645 2355777..2355995 1 NC_007606.1 D-serine permease 2355995 3795645 SDY_2560 Shigella dysenteriae Sd197 D-serine permease YP_404117.1 2355777 D 300267 CDS YP_404118.1 82777769 3795646 2356013..2357341 1 NC_007606.1 deaminase; catalyzes the formation of pyruvate from serine; D-serine dehydratase 2357341 dsdA 3795646 dsdA Shigella dysenteriae Sd197 D-serine dehydratase YP_404118.1 2356013 D 300267 CDS YP_404119.1 82777770 3795647 complement(2357449..2358987) 1 NC_007606.1 Code: GEPR; COG: COG0477; multidrug resistance protein Y 2358987 emrY 3795647 emrY Shigella dysenteriae Sd197 multidrug resistance protein Y YP_404119.1 2357449 R 300267 CDS YP_404120.1 82777771 3795648 complement(2358987..2360150) 1 NC_007606.1 Code: V; COG: COG1566; multidrug resistance protein K 2360150 emrK 3795648 emrK Shigella dysenteriae Sd197 multidrug resistance protein K YP_404120.1 2358987 R 300267 CDS YP_009000788.1 578793258 18263102 2360937..2361209 1 NC_007606.1 insertion element iso-IS1N protein InsA 2361209 18263102 SDY_4713 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000788.1 2360937 D 300267 CDS YP_404121.1 82777772 3795650 2361236..2361631 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2361631 3795650 SDY_2565 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404121.1 2361236 D 300267 CDS YP_404122.1 82777773 3795652 complement(2363192..2363587) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2363587 3795652 SDY_2567 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404122.1 2363192 R 300267 CDS YP_009000789.1 578793259 18263103 complement(2363614..2363886) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2363886 18263103 SDY_4714 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000789.1 2363614 R 300267 CDS YP_404123.1 82777774 3797086 complement(2364711..2364986) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2364986 insA 3797086 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404123.1 2364711 R 300267 CDS YP_404124.1 82777775 3797087 complement(2365253..2366437) 1 NC_007606.1 Code: C; COG: COG1804; hypothetical protein 2366437 yfdE 3797087 yfdE Shigella dysenteriae Sd197 hypothetical protein YP_404124.1 2365253 R 300267 CDS YP_404125.1 82777776 3797088 complement(2366472..2367416) 1 NC_007606.1 member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV 2367416 3797088 SDY_2570 Shigella dysenteriae Sd197 transporter YfdV YP_404125.1 2366472 R 300267 CDS YP_404126.1 82777777 3797089 complement(2367486..2369180) 1 NC_007606.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 2369180 3797089 SDY_2571 Shigella dysenteriae Sd197 oxalyl-CoA decarboxylase YP_404126.1 2367486 R 300267 CDS YP_404127.1 82777778 3797090 complement(2369234..2370484) 1 NC_007606.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2370484 3797090 SDY_2572 Shigella dysenteriae Sd197 formyl-coenzyme A transferase YP_404127.1 2369234 R 300267 CDS YP_404128.1 82777779 3797091 complement(2370996..2371628) 1 NC_007606.1 hypothetical protein 2371628 3797091 SDY_2573 Shigella dysenteriae Sd197 hypothetical protein YP_404128.1 2370996 R 300267 CDS YP_404129.1 82777780 3797092 2371924..2372199 1 NC_007606.1 hypothetical protein 2372199 3797092 SDY_2574 Shigella dysenteriae Sd197 hypothetical protein YP_404129.1 2371924 D 300267 CDS YP_404130.1 82777781 3797093 complement(2372276..2372518) 1 NC_007606.1 hypothetical protein 2372518 3797093 SDY_2575 Shigella dysenteriae Sd197 hypothetical protein YP_404130.1 2372276 R 300267 CDS YP_404131.2 161950076 3797094 2372871..2373791 1 NC_007606.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2373791 ddg 3797094 ddg Shigella dysenteriae Sd197 lipid A biosynthesis palmitoleoyl acyltransferase YP_404131.2 2372871 D 300267 CDS YP_404132.1 82777783 3797095 complement(2374284..2375522) 1 NC_007606.1 Code: E; COG: COG0436; aminotransferase 2375522 3797095 SDY_2577 Shigella dysenteriae Sd197 aminotransferase YP_404132.1 2374284 R 300267 CDS YP_404133.1 82777784 3797096 complement(2375602..2375847) 1 NC_007606.1 hypothetical protein 2375847 3797096 SDY_2578 Shigella dysenteriae Sd197 hypothetical protein YP_404133.1 2375602 R 300267 CDS YP_404134.1 82777785 3797097 2375899..2377596 1 NC_007606.1 Code: T; COG: COG3275; sensor protein 2377596 3797097 SDY_2579 Shigella dysenteriae Sd197 sensor protein YP_404134.1 2375899 D 300267 CDS YP_404135.1 82777786 3797101 complement(2381611..2382648) 1 NC_007606.1 metalloprotein; exoaminopeptidase 2382648 3797101 SDY_2583 Shigella dysenteriae Sd197 exoaminopeptidase YP_404135.1 2381611 R 300267 CDS YP_404136.1 82777787 3797102 complement(2382648..2383562) 1 NC_007606.1 Code: E; COG: COG0006; peptidase 2383562 3797102 SDY_2584 Shigella dysenteriae Sd197 peptidase YP_404136.1 2382648 R 300267 CDS YP_404137.1 82777788 3797103 complement(2383577..2384824) 1 NC_007606.1 Code: G; COG: COG1299; transport protein 2384824 3797103 SDY_2585 Shigella dysenteriae Sd197 transport protein YP_404137.1 2383577 R 300267 CDS YP_404138.1 82777789 3797104 complement(2384846..2385172) 1 NC_007606.1 Code: G; COG: COG1445; PTS system transporter subunit IIB 2385172 3797104 SDY_2586 Shigella dysenteriae Sd197 PTS system transporter subunit IIB YP_404138.1 2384846 R 300267 CDS YP_404139.1 82777790 3797105 complement(2385391..2386356) 1 NC_007606.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2386356 glk 3797105 glk Shigella dysenteriae Sd197 glucokinase YP_404139.1 2385391 R 300267 CDS YP_404140.1 82777791 3798544 complement(2386735..2387973) 1 NC_007606.1 Code: P; COG: COG1914; manganese transport protein MntH 2387973 3798544 SDY_2588 Shigella dysenteriae Sd197 manganese transport protein MntH YP_404140.1 2386735 R 300267 CDS YP_404141.1 82777792 3798545 2388271..2388681 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2388681 3798545 SDY_2589 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_404141.1 2388271 D 300267 CDS YP_404143.1 82777794 3798547 complement(2389430..2389645) 1 NC_007606.1 insertion element iso-IS1n protein InsB 2389645 3798547 SDY_2591 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404143.1 2389430 R 300267 CDS YP_009000790.1 578793260 18263104 complement(2389852..2390124) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2390124 18263104 SDY_4715 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000790.1 2389852 R 300267 CDS YP_404145.1 82777796 3798549 2390420..2391622 1 NC_007606.1 Code: F; COG: COG1972; nucleosides transporter 2391622 nupC 3798549 nupC Shigella dysenteriae Sd197 nucleosides transporter YP_404145.1 2390420 D 300267 CDS YP_404146.1 82777797 3798552 2394271..2394630 1 NC_007606.1 hypothetical protein 2394630 yfeC 3798552 yfeC Shigella dysenteriae Sd197 hypothetical protein YP_404146.1 2394271 D 300267 CDS YP_404147.1 82777798 3798553 2394632..2395024 1 NC_007606.1 hypothetical protein 2395024 yfeD 3798553 yfeD Shigella dysenteriae Sd197 hypothetical protein YP_404147.1 2394632 D 300267 CDS YP_404148.1 82777799 3798554 complement(2395064..2396272) 1 NC_007606.1 Code: L; COG: COG0675; virulence protein 2396272 3798554 SDY_2598 Shigella dysenteriae Sd197 virulence protein YP_404148.1 2395064 R 300267 CDS YP_404149.1 82777800 3798555 2396280..2396822 1 NC_007606.1 Code: L; COG: COG1943; transposase TnA 2396822 3798555 SDY_2599 Shigella dysenteriae Sd197 transposase TnA YP_404149.1 2396280 D 300267 CDS YP_404150.1 82777801 3798556 complement(2396823..2398238) 1 NC_007606.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2398238 gltX 3798556 gltX Shigella dysenteriae Sd197 glutamyl-tRNA synthetase YP_404150.1 2396823 R 300267 CDS YP_404151.1 82777802 3799788 2399046..2399387 1 NC_007606.1 hypothetical protein 2399387 flxA 3799788 flxA Shigella dysenteriae Sd197 hypothetical protein YP_404151.1 2399046 D 300267 CDS YP_404152.1 82777803 3799790 2400394..2401392 1 NC_007606.1 Code: R; COG: COG0385; cytochrome oxidase 2401392 yfeH 3799790 yfeH Shigella dysenteriae Sd197 cytochrome oxidase YP_404152.1 2400394 D 300267 CDS YP_404153.1 82777804 3799791 complement(2401389..2401607) 1 NC_007606.1 Code: S; COG: COG3530; hypothetical protein 2401607 3799791 SDY_2607 Shigella dysenteriae Sd197 hypothetical protein YP_404153.1 2401389 R 300267 CDS YP_404154.1 82777805 3799792 complement(2401609..2403624) 1 NC_007606.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2403624 ligA 3799792 ligA Shigella dysenteriae Sd197 NAD-dependent DNA ligase LigA YP_404154.1 2401609 R 300267 CDS YP_404155.1 82777806 3799793 complement(2403695..2404693) 1 NC_007606.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2404693 zipA 3799793 zipA Shigella dysenteriae Sd197 cell division protein ZipA YP_404155.1 2403695 R 300267 CDS YP_404156.1 82777807 3799794 2404923..2405684 1 NC_007606.1 role in sulfur assimilation; sulfate transport protein CysZ 2405684 cysZ 3799794 cysZ Shigella dysenteriae Sd197 sulfate transport protein CysZ YP_404156.1 2404923 D 300267 CDS YP_404157.1 82777808 3799795 2405869..2406840 1 NC_007606.1 O-acetylserine sulfhydrolase A; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2406840 cysK 3799795 cysK Shigella dysenteriae Sd197 cysteine synthase A YP_404157.1 2405869 D 300267 CDS YP_404158.1 82777809 3799796 2407224..2407481 1 NC_007606.1 Code: G; COG: COG1925; phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) 2407481 ptsH 3799796 ptsH Shigella dysenteriae Sd197 phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) YP_404158.1 2407224 D 300267 CDS YP_404159.1 82777810 3799797 2407526..2409253 1 NC_007606.1 ''Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system''; phosphoenolpyruvate-protein phosphotransferase 2409253 ptsI 3799797 ptsI Shigella dysenteriae Sd197 phosphoenolpyruvate-protein phosphotransferase YP_404159.1 2407526 D 300267 CDS YP_404160.1 82777811 3799798 2409294..2409803 1 NC_007606.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit IIA 2409803 crr 3799798 crr Shigella dysenteriae Sd197 PTS system glucose-specific transporter subunit IIA YP_404160.1 2409294 D 300267 CDS YP_404161.1 82777812 3799799 complement(2409846..2410697) 1 NC_007606.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2410697 pdxK 3799799 pdxK Shigella dysenteriae Sd197 pyridoxal kinase YP_404161.1 2409846 R 300267 CDS YP_404162.1 82777813 3799800 2410802..2411170 1 NC_007606.1 hypothetical protein 2411170 yfeK 3799800 yfeK Shigella dysenteriae Sd197 hypothetical protein YP_404162.1 2410802 D 300267 CDS YP_404163.1 82777814 3799801 complement(2411173..2412084) 1 NC_007606.1 O-acetylserine sulfhydrolase B; catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2412084 cysM 3799801 cysM Shigella dysenteriae Sd197 cysteine synthase B YP_404163.1 2411173 R 300267 CDS YP_404164.1 82777815 3799802 complement(2412218..2413315) 1 NC_007606.1 chromate resistance; Code: P; COG: COG1118; sulfate/thiosulfate ABC transporter ATP-binding protein 2413315 cysA 3799802 cysA Shigella dysenteriae Sd197 sulfate/thiosulfate ABC transporter ATP-binding protein YP_404164.1 2412218 R 300267 CDS YP_404165.1 82777816 3799803 complement(2413305..2414180) 1 NC_007606.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate ABC transporter substrate-binding protein 2414180 cysW 3799803 cysW Shigella dysenteriae Sd197 sulfate/thiosulfate ABC transporter substrate-binding protein YP_404165.1 2413305 R 300267 CDS YP_404166.1 82777817 3799804 complement(2414180..2415013) 1 NC_007606.1 Code: O; COG: COG0555; sulfate/thiosulfate transporter permease 2415013 cysU 3799804 cysU Shigella dysenteriae Sd197 sulfate/thiosulfate transporter permease YP_404166.1 2414180 R 300267 CDS YP_404167.1 82777818 3799805 complement(2415013..2416029) 1 NC_007606.1 Code: P; COG: COG4150; thiosulfate transporter extracellular solute-binding protein 2416029 cysP 3799805 cysP Shigella dysenteriae Sd197 thiosulfate transporter extracellular solute-binding protein YP_404167.1 2415013 R 300267 CDS YP_404168.2 161950075 3797949 complement(2416333..2417124) 1 NC_007606.1 Code: IQR; COG: COG1028; short chain dehydrogenase 2417124 ucpA 3797949 ucpA Shigella dysenteriae Sd197 short chain dehydrogenase YP_404168.2 2416333 R 300267 CDS YP_404169.1 82777820 3797950 complement(2417253..2418110) 1 NC_007606.1 Code: K; COG: COG1737; hypothetical protein 2418110 yfeT 3797950 yfeT Shigella dysenteriae Sd197 hypothetical protein YP_404169.1 2417253 R 300267 CDS YP_404170.1 82777821 3797951 2418274..2419170 1 NC_007606.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 2419170 murQ 3797951 murQ Shigella dysenteriae Sd197 N-acetylmuramic acid 6-phosphate etherase YP_404170.1 2418274 D 300267 CDS YP_404171.1 82777822 3797952 2419174..2420598 1 NC_007606.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; N-acetylmuramic acid phosphotransfer permease 2420598 murP 3797952 murP Shigella dysenteriae Sd197 N-acetylmuramic acid phosphotransfer permease YP_404171.1 2419174 D 300267 CDS YP_009000791.1 578793261 18263105 complement(2421945..2422217) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2422217 18263105 SDY_4716 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000791.1 2421945 R 300267 CDS YP_404174.1 82777825 3797956 complement(2422738..2423664) 1 NC_007606.1 Code: P; COG: COG2837; hypothetical protein 2423664 3797956 SDY_2629 Shigella dysenteriae Sd197 hypothetical protein YP_404174.1 2422738 R 300267 CDS YP_404175.1 82777826 3797957 complement(2423733..2424308) 1 NC_007606.1 hypothetical protein 2424308 3797957 SDY_2630 Shigella dysenteriae Sd197 hypothetical protein YP_404175.1 2423733 R 300267 CDS YP_404176.1 82777827 3797958 complement(2424369..2424824) 1 NC_007606.1 hypothetical protein 2424824 3797958 SDY_2631 Shigella dysenteriae Sd197 hypothetical protein YP_404176.1 2424369 R 300267 CDS YP_404177.2 161950074 3797959 complement(2424805..2425230) 1 NC_007606.1 Code: R; COG: COG0456; acetyltransferase 2425230 3797959 SDY_2632 Shigella dysenteriae Sd197 acetyltransferase YP_404177.2 2424805 R 300267 CDS YP_404178.1 82777829 3797960 2425444..2426313 1 NC_007606.1 Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase 2426313 amiA 3797960 amiA Shigella dysenteriae Sd197 N-acetylmuramoyl-L-alanine amidase YP_404178.1 2425444 D 300267 CDS YP_404179.1 82777830 3797961 2426317..2427216 1 NC_007606.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2427216 hemF 3797961 hemF Shigella dysenteriae Sd197 coproporphyrinogen III oxidase YP_404179.1 2426317 D 300267 CDS YP_404180.1 82777831 3797962 complement(2427222..2428274) 1 NC_007606.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2428274 yfeG 3797962 yfeG Shigella dysenteriae Sd197 transcriptional regulator EutR YP_404180.1 2427222 R 300267 CDS YP_404181.1 82777832 3797963 complement(2428320..2428826) 1 NC_007606.1 Code: QC; COG: COG4577; hypothetical protein 2428826 3797963 SDY_2636 Shigella dysenteriae Sd197 hypothetical protein YP_404181.1 2428320 R 300267 CDS YP_404182.1 82777833 3797964 complement(2428833..2429492) 1 NC_007606.1 Code: E; COG: COG4816; hypothetical protein 2429492 3797964 SDY_2637 Shigella dysenteriae Sd197 hypothetical protein YP_404182.1 2428833 R 300267 CDS YP_404183.1 82777834 3797965 complement(2429502..2430389) 1 NC_007606.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2430389 eutC 3797965 eutC Shigella dysenteriae Sd197 ethanolamine ammonia-lyase small subunit YP_404183.1 2429502 R 300267 CDS YP_009000792.1 578793262 18263106 2431210..2431482 1 NC_007606.1 insertion element iso-IS1N protein InsA 2431482 18263106 SDY_4717 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000792.1 2431210 D 300267 CDS YP_009000793.1 578793263 18263107 complement(2432675..2432947) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2432947 18263107 SDY_4718 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000793.1 2432675 R 300267 CDS YP_404188.1 82777839 3797297 2432843..2433073 1 NC_007606.1 hypothetical protein 2433073 3797297 SDY_2644 Shigella dysenteriae Sd197 hypothetical protein YP_404188.1 2432843 D 300267 CDS YP_404189.1 82777840 3797298 complement(2433384..2435663) 1 NC_007606.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2435663 3797298 SDY_2645 Shigella dysenteriae Sd197 malic enzyme YP_404189.1 2433384 R 300267 CDS YP_404190.1 82777841 3797301 complement(2437903..2438298) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2438298 3797301 SDY_2648 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404190.1 2437903 R 300267 CDS YP_009000794.1 578793264 18263108 complement(2438325..2438597) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2438597 18263108 SDY_4719 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000794.1 2438325 R 300267 CDS YP_404191.1 82777842 3797302 complement(2439779..2440846) 1 NC_007606.1 hypothetical protein 2440846 3797302 SDY_2649 Shigella dysenteriae Sd197 hypothetical protein YP_404191.1 2439779 R 300267 CDS YP_404192.1 82777843 3797303 complement(2440972..2441547) 1 NC_007606.1 Code: LR; COG: COG0494; hypothetical protein 2441547 yffH 3797303 yffH Shigella dysenteriae Sd197 hypothetical protein YP_404192.1 2440972 R 300267 CDS YP_404193.1 82777844 3797304 complement(2441615..2443594) 1 NC_007606.1 ''unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)''; oxidoreductase Fe-S binding subunit 2443594 yffG 3797304 yffG Shigella dysenteriae Sd197 oxidoreductase Fe-S binding subunit YP_404193.1 2441615 R 300267 CDS YP_404194.1 82777845 3797305 complement(2443626..2444021) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2444021 3797305 SDY_2652 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404194.1 2443626 R 300267 CDS YP_009000795.1 578793265 18263109 complement(2444048..2444320) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2444320 18263109 SDY_4720 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000795.1 2444048 R 300267 CDS YP_404195.1 82777846 3797306 2444574..2446274 1 NC_007606.1 protein histidine kinase (acts on NarP and narL); Code: T; COG: COG3850; nitrate/nitrite sensor protein NarQ 2446274 narQ 3797306 narQ Shigella dysenteriae Sd197 nitrate/nitrite sensor protein NarQ YP_404195.1 2444574 D 300267 CDS YP_404196.1 82777847 3797307 2446438..2449551 1 NC_007606.1 sensitivity to acriflavine, integral membrane protein, possible efflux pump; Code: V; COG: COG0841; aminoglycoside/multidrug efflux system 2449551 acrD 3797307 acrD Shigella dysenteriae Sd197 aminoglycoside/multidrug efflux system YP_404196.1 2446438 D 300267 CDS YP_404197.1 82777848 3797308 2450090..2450446 1 NC_007606.1 Code: P; COG: COG1393; hypothetical protein 2450446 yffB 3797308 yffB Shigella dysenteriae Sd197 hypothetical protein YP_404197.1 2450090 D 300267 CDS YP_404198.1 82777849 3797309 2450450..2451577 1 NC_007606.1 ''dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.''; succinyl-diaminopimelate desuccinylase 2451577 dapE 3797309 dapE Shigella dysenteriae Sd197 succinyl-diaminopimelate desuccinylase YP_404198.1 2450450 D 300267 CDS YP_404199.2 228861761 3797310 2451605..2451805 1 NC_007606.1 hypothetical protein 2451805 3797310 SDY_2657 Shigella dysenteriae Sd197 hypothetical protein YP_404199.2 2451605 D 300267 CDS YP_404202.1 82777853 3797313 complement(2452667..2453062) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2453062 3797313 SDY_2660 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404202.1 2452667 R 300267 CDS YP_009000796.1 578793266 18263110 complement(2453089..2453361) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2453361 18263110 SDY_4721 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000796.1 2453089 R 300267 CDS YP_404203.1 82777854 3798579 complement(2453433..2455448) 1 NC_007606.1 Code: R; COG: COG1444; hypothetical protein 2455448 ypfI 3798579 ypfI Shigella dysenteriae Sd197 hypothetical protein YP_404203.1 2453433 R 300267 CDS YP_404206.1 82777857 3798582 complement(2456494..2457207) 1 NC_007606.1 SAICAR synthetase; catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2457207 purC 3798582 purC Shigella dysenteriae Sd197 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_404206.1 2456494 R 300267 CDS YP_404208.1 82777859 3798584 complement(2457420..2458457) 1 NC_007606.1 Code: M; COG: COG3317; lipoprotein 2458457 nlpB 3798584 nlpB Shigella dysenteriae Sd197 lipoprotein YP_404208.1 2457420 R 300267 CDS YP_404209.1 82777860 3798585 complement(2458471..2459349) 1 NC_007606.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2459349 dapA 3798585 dapA Shigella dysenteriae Sd197 dihydrodipicolinate synthase YP_404209.1 2458471 R 300267 CDS YP_404210.2 161950072 3798586 2459495..2460067 1 NC_007606.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2460067 gcvR 3798586 gcvR Shigella dysenteriae Sd197 glycine cleavage system transcriptional repressor YP_404210.2 2459495 D 300267 CDS YP_404211.1 82777862 3798587 2460067..2460537 1 NC_007606.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2460537 bcp 3798587 bcp Shigella dysenteriae Sd197 thioredoxin-dependent thiol peroxidase YP_404211.1 2460067 D 300267 CDS YP_404212.1 82777863 3798588 2460751..2461407 1 NC_007606.1 Code: C; COG: COG1142; hydrogenase 4 Fe-S subunit 2461407 hyfA 3798588 hyfA Shigella dysenteriae Sd197 hydrogenase 4 Fe-S subunit YP_404212.1 2460751 D 300267 CDS YP_404213.1 82777864 3798589 2461407..2463425 1 NC_007606.1 Code: CP; COG: COG0651; hydrogenase 4 subunit B 2463425 hyfB 3798589 hyfB Shigella dysenteriae Sd197 hydrogenase 4 subunit B YP_404213.1 2461407 D 300267 CDS YP_404214.1 82777865 3798590 2463415..2464383 1 NC_007606.1 Code: C; COG: COG0650; hydrogenase 4 membrane subunit 2464383 hyfC 3798590 hyfC Shigella dysenteriae Sd197 hydrogenase 4 membrane subunit YP_404214.1 2463415 D 300267 CDS YP_404215.1 82777866 3798592 2465851..2466501 1 NC_007606.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2466501 hyfE 3798592 hyfE Shigella dysenteriae Sd197 hydrogenase 4 membrane subunit YP_404215.1 2465851 D 300267 CDS YP_404216.1 82777867 3798593 2466506..2468086 1 NC_007606.1 Code: CP; COG: COG0651; hydrogenase 4 subunit F 2468086 hyfF 3798593 hyfF Shigella dysenteriae Sd197 hydrogenase 4 subunit F YP_404216.1 2466506 D 300267 CDS YP_404217.1 82777868 3798594 2468076..2469791 1 NC_007606.1 Code: C; COG: COG3261; hydrogenase 4 subunit G 2469791 hyfG 3798594 hyfG Shigella dysenteriae Sd197 hydrogenase 4 subunit G YP_404217.1 2468076 D 300267 CDS YP_404218.1 82777869 3798596 2470343..2471101 1 NC_007606.1 Code: C; COG: COG3260; hydrogenase 4 Fe-S subunit 2471101 hyfI 3798596 hyfI Shigella dysenteriae Sd197 hydrogenase 4 Fe-S subunit YP_404218.1 2470343 D 300267 CDS YP_404219.1 82777870 3798597 2471031..2471507 1 NC_007606.1 protein processing element 2471507 3798597 SDY_2679 Shigella dysenteriae Sd197 protein processing element YP_404219.1 2471031 D 300267 CDS YP_404220.1 82777871 3798099 2473571..2474419 1 NC_007606.1 formate channel 2; inner membrane protein presumed to act as a formate transporter; member of the hyf operon; formate transporter 2474419 focB 3798099 focB Shigella dysenteriae Sd197 formate transporter YP_404220.1 2473571 D 300267 CDS YP_404221.1 82777872 3798100 complement(2474457..2475518) 1 NC_007606.1 Code: R; COG: COG0628; permease 2475518 perM 3798100 perM Shigella dysenteriae Sd197 permease YP_404221.1 2474457 R 300267 CDS YP_404222.1 82777873 3798101 2475732..2477195 1 NC_007606.1 Code: R; COG: COG4783; hypothetical protein 2477195 3798101 SDY_2683 Shigella dysenteriae Sd197 hypothetical protein YP_404222.1 2475732 D 300267 CDS YP_404223.1 82777874 3798102 2477216..2477575 1 NC_007606.1 Code: P; COG: COG1393; oxidoreductase 2477575 3798102 SDY_2684 Shigella dysenteriae Sd197 oxidoreductase YP_404223.1 2477216 D 300267 CDS YP_404224.1 82777875 3798103 complement(2477713..2478459) 1 NC_007606.1 ''controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP''; DNA replication initiation factor 2478459 3798103 SDY_2685 Shigella dysenteriae Sd197 DNA replication initiation factor YP_404224.1 2477713 R 300267 CDS YP_404225.1 82777876 3798104 complement(2478509..2479798) 1 NC_007606.1 Code: F; COG: COG2233; uracil transporter 2479798 uraA 3798104 uraA Shigella dysenteriae Sd197 uracil transporter YP_404225.1 2478509 R 300267 CDS YP_404226.2 161950071 3798105 complement(2479884..2480510) 1 NC_007606.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2480510 upp 3798105 upp Shigella dysenteriae Sd197 uracil phosphoribosyltransferase YP_404226.2 2479884 R 300267 CDS YP_404227.1 82777878 3798106 2480836..2481873 1 NC_007606.1 AIR synthetase; catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2481873 purM 3798106 purM Shigella dysenteriae Sd197 phosphoribosylaminoimidazole synthetase YP_404227.1 2480836 D 300267 CDS YP_404228.1 82777879 3798107 2481873..2482511 1 NC_007606.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2482511 purN 3798107 purN Shigella dysenteriae Sd197 phosphoribosylglycinamide formyltransferase YP_404228.1 2481873 D 300267 CDS YP_404229.1 82777880 3798108 2482682..2484748 1 NC_007606.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2484748 ppk 3798108 ppk Shigella dysenteriae Sd197 polyphosphate kinase YP_404229.1 2482682 D 300267 CDS YP_404230.1 82777881 3798109 2484753..2486294 1 NC_007606.1 Code: FP; COG: COG0248; exopolyphosphatase 2486294 ppx 3798109 ppx Shigella dysenteriae Sd197 exopolyphosphatase YP_404230.1 2484753 D 300267 CDS YP_404231.2 161950070 3798111 complement(2488581..2488976) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2488976 3798111 SDY_2693 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404231.2 2488581 R 300267 CDS YP_009000797.1 578793267 18263111 complement(2489003..2489275) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2489275 18263111 SDY_4722 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000797.1 2489003 R 300267 CDS YP_404233.1 82777884 3798113 complement(2489488..2489883) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2489883 3798113 SDY_2695 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404233.1 2489488 R 300267 CDS YP_009000798.1 578793268 18263112 complement(2489910..2490137) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2490137 18263112 SDY_4723 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000798.1 2489910 R 300267 CDS YP_404234.1 82777885 3798114 2490459..2490650 1 NC_007606.1 hypothetical protein 2490650 3798114 SDY_2696 Shigella dysenteriae Sd197 hypothetical protein YP_404234.1 2490459 D 300267 CDS YP_009000799.1 578793269 18263113 2491021..2491293 1 NC_007606.1 insertion element iso-IS1N protein InsA 2491293 18263113 SDY_4724 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000799.1 2491021 D 300267 CDS YP_404236.1 82777887 3798116 2491320..2491715 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2491715 3798116 SDY_2698 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404236.1 2491320 D 300267 CDS YP_404237.1 82777888 3798117 2491735..2492265 1 NC_007606.1 Code: M; COG: COG3133; outer membrane lipoprotein 2492265 3798117 SDY_2699 Shigella dysenteriae Sd197 outer membrane lipoprotein YP_404237.1 2491735 D 300267 CDS YP_404238.2 161950069 3798802 complement(2492236..2493141) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2493141 3798802 SDY_2700 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_404238.2 2492236 R 300267 CDS YP_404239.1 82777890 3798803 complement(2493099..2493464) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2493464 3798803 SDY_2701 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_404239.1 2493099 R 300267 CDS YP_404240.1 82777891 3798804 2493605..2494144 1 NC_007606.1 hypothetical protein 2494144 3798804 SDY_2702 Shigella dysenteriae Sd197 hypothetical protein YP_404240.1 2493605 D 300267 CDS YP_404241.1 82777892 3798805 complement(2494237..2495814) 1 NC_007606.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2495814 guaA 3798805 guaA Shigella dysenteriae Sd197 GMP synthase YP_404241.1 2494237 R 300267 CDS YP_404242.1 82777893 3798806 complement(2495883..2497349) 1 NC_007606.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2497349 guaB 3798806 guaB Shigella dysenteriae Sd197 inosine 5'-monophosphate dehydrogenase YP_404242.1 2495883 R 300267 CDS YP_404243.1 82777894 3798807 2497511..2498881 1 NC_007606.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2498881 xseA 3798807 xseA Shigella dysenteriae Sd197 exodeoxyribonuclease VII large subunit YP_404243.1 2497511 D 300267 CDS YP_404244.1 82777895 3798808 complement(2498878..2499114) 1 NC_007606.1 hypothetical protein 2499114 3798808 SDY_2706 Shigella dysenteriae Sd197 hypothetical protein YP_404244.1 2498878 R 300267 CDS YP_404245.2 161950068 3798809 complement(2499162..2500634) 1 NC_007606.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2500634 engA 3798809 engA Shigella dysenteriae Sd197 GTP-binding protein EngA YP_404245.2 2499162 R 300267 CDS YP_404246.1 82777897 3798810 complement(2500752..2501930) 1 NC_007606.1 ''with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis''; outer membrane protein assembly complex subunit YfgL 2501930 3798810 SDY_2708 Shigella dysenteriae Sd197 outer membrane protein assembly complex subunit YfgL YP_404246.1 2500752 R 300267 CDS YP_404247.1 82777898 3798811 complement(2501941..2502561) 1 NC_007606.1 Code: S; COG: COG2976; hypothetical protein 2502561 3798811 SDY_2709 Shigella dysenteriae Sd197 hypothetical protein YP_404247.1 2501941 R 300267 CDS YP_404248.1 82777899 3798812 complement(2502579..2503853) 1 NC_007606.1 ''catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG''; histidyl-tRNA synthetase 2503853 hisS 3798812 hisS Shigella dysenteriae Sd197 histidyl-tRNA synthetase YP_404248.1 2502579 R 300267 CDS YP_404249.1 82777900 3798813 complement(2503964..2505082) 1 NC_007606.1 ''catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis''; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2505082 ispG 3798813 ispG Shigella dysenteriae Sd197 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_404249.1 2503964 R 300267 CDS YP_404250.1 82777901 3798814 complement(2505109..2506122) 1 NC_007606.1 Code: S; COG: COG1426; hypothetical protein 2506122 yfgA 3798814 yfgA Shigella dysenteriae Sd197 hypothetical protein YP_404250.1 2505109 R 300267 CDS YP_404251.1 82777902 3798815 complement(2506407..2507561) 1 NC_007606.1 Code: R; COG: COG0820; hypothetical protein 2507561 yfgB 3798815 yfgB Shigella dysenteriae Sd197 hypothetical protein YP_404251.1 2506407 R 300267 CDS YP_404252.1 82777903 3798816 complement(2507711..2508142) 1 NC_007606.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2508142 ndk 3798816 ndk Shigella dysenteriae Sd197 nucleoside diphosphate kinase YP_404252.1 2507711 R 300267 CDS YP_404253.2 161950067 3798819 2515771..2516616 1 NC_007606.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2516616 sseA 3798819 sseA Shigella dysenteriae Sd197 3-mercaptopyruvate sulfurtransferase YP_404253.2 2515771 D 300267 CDS YP_404254.2 161950066 3798820 complement(2517763..2518539) 1 NC_007606.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2518539 sseB 3798820 sseB Shigella dysenteriae Sd197 enhanced serine sensitivity protein SseB YP_404254.2 2517763 R 300267 CDS YP_404255.2 161950065 3798821 complement(2518682..2519965) 1 NC_007606.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase 2519965 pepB 3798821 pepB Shigella dysenteriae Sd197 aminopeptidase YP_404255.2 2518682 R 300267 CDS YP_404256.1 82777907 3798253 complement(2520143..2520343) 1 NC_007606.1 Code: S; COG: COG2975; hypothetical protein 2520343 yfhJ 3798253 yfhJ Shigella dysenteriae Sd197 hypothetical protein YP_404256.1 2520143 R 300267 CDS YP_404257.1 82777908 3798254 complement(2520355..2520690) 1 NC_007606.1 Code: C; COG: COG0633; [2FE-2S] ferredoxin, electron carrer protein 2520690 fdx 3798254 fdx Shigella dysenteriae Sd197 [2FE-2S] ferredoxin, electron carrer protein YP_404257.1 2520355 R 300267 CDS YP_404258.1 82777909 3798255 complement(2520692..2522542) 1 NC_007606.1 heat shock protein, chaperone, member of Hsp70 protein family; involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2522542 hscA 3798255 hscA Shigella dysenteriae Sd197 chaperone protein HscA YP_404258.1 2520692 R 300267 CDS YP_404259.1 82777910 3798256 complement(2522559..2523074) 1 NC_007606.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2523074 hscB 3798256 hscB Shigella dysenteriae Sd197 co-chaperone HscB YP_404259.1 2522559 R 300267 CDS YP_404260.1 82777911 3798257 complement(2523170..2523493) 1 NC_007606.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2523493 iscA 3798257 iscA Shigella dysenteriae Sd197 iron-sulfur cluster assembly protein YP_404260.1 2523170 R 300267 CDS YP_404261.1 82777912 3798258 complement(2523510..2523896) 1 NC_007606.1 Code: C; COG: COG0822; scaffold protein 2523896 3798258 SDY_2725 Shigella dysenteriae Sd197 scaffold protein YP_404261.1 2523510 R 300267 CDS YP_404262.1 82777913 3798259 complement(2523924..2525162) 1 NC_007606.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2525162 yfhO 3798259 yfhO Shigella dysenteriae Sd197 cysteine desulfurase YP_404262.1 2523924 R 300267 CDS YP_404263.1 82777914 3798260 complement(2525250..2525738) 1 NC_007606.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2525738 3798260 SDY_2727 Shigella dysenteriae Sd197 DNA-binding transcriptional regulator IscR YP_404263.1 2525250 R 300267 CDS YP_404264.1 82777915 3798261 complement(2526038..2526775) 1 NC_007606.1 Code: J; COG: COG0565; ATP synthase subunit beta 2526775 3798261 SDY_2728 Shigella dysenteriae Sd197 ATP synthase subunit beta YP_404264.1 2526038 R 300267 CDS YP_404265.1 82777916 3798262 2526894..2527697 1 NC_007606.1 enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action; Code: G; COG: COG0483; inositol monophosphatase 2527697 suhB 3798262 suhB Shigella dysenteriae Sd197 inositol monophosphatase YP_404265.1 2526894 D 300267 CDS YP_404266.1 82777917 3798263 2527815..2528696 1 NC_007606.1 Code: R; COG: COG1073; hydrolase 2528696 3798263 SDY_2730 Shigella dysenteriae Sd197 hydrolase YP_404266.1 2527815 D 300267 CDS YP_404267.2 161950064 3798264 2528887..2530167 1 NC_007606.1 Code: K; COG: COG3711; stationary phase inducible protein CsiE 2530167 csiE 3798264 csiE Shigella dysenteriae Sd197 stationary phase inducible protein CsiE YP_404267.2 2528887 D 300267 CDS YP_404268.1 82777919 3798265 complement(2530159..2531298) 1 NC_007606.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 2531298 hcaT 3798265 hcaT Shigella dysenteriae Sd197 3-phenylpropionic acid transporter YP_404268.1 2530159 R 300267 CDS YP_404269.1 82777920 3798267 complement(2531458..2531748) 1 NC_007606.1 hypothetical protein 2531748 3798267 SDY_2734 Shigella dysenteriae Sd197 hypothetical protein YP_404269.1 2531458 R 300267 CDS YP_404270.1 82777921 3798268 2531970..2532365 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2532365 3798268 SDY_2735 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404270.1 2531970 D 300267 CDS YP_404273.1 82777924 3797611 complement(2536016..2536411) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2536411 3797611 SDY_2739 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404273.1 2536016 R 300267 CDS YP_009000800.1 578793270 18263114 complement(2536438..2536710) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2536710 18263114 SDY_4725 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000800.1 2536438 R 300267 CDS YP_404274.1 82777925 3797612 2536864..2538063 1 NC_007606.1 Code: KG; COG: COG1940; NAGC-like transcriptional regulator 2538063 yphH 3797612 yphH Shigella dysenteriae Sd197 NAGC-like transcriptional regulator YP_404274.1 2536864 D 300267 CDS YP_404275.1 82777926 3797613 complement(2538126..2539379) 1 NC_007606.1 ''catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate''; serine hydroxymethyltransferase 2539379 glyA 3797613 glyA Shigella dysenteriae Sd197 serine hydroxymethyltransferase YP_404275.1 2538126 R 300267 CDS YP_404276.1 82777927 3797614 2539706..2540896 1 NC_007606.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2540896 hmpA 3797614 hmpA Shigella dysenteriae Sd197 nitric oxide dioxygenase YP_404276.1 2539706 D 300267 CDS YP_404277.1 82777928 3797615 complement(2540941..2541279) 1 NC_007606.1 ''indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA''; nitrogen regulatory protein P-II 1 2541279 glnB 3797615 glnB Shigella dysenteriae Sd197 nitrogen regulatory protein P-II 1 YP_404277.1 2540941 R 300267 CDS YP_404278.1 82777929 3797616 complement(2541340..2542674) 1 NC_007606.1 Code: T; COG: COG2204; 2-component transcriptional regulator 2542674 yfhA 3797616 yfhA Shigella dysenteriae Sd197 2-component transcriptional regulator YP_404278.1 2541340 R 300267 CDS YP_404279.1 82777930 3797617 complement(2542664..2543377) 1 NC_007606.1 hypothetical protein 2543377 yfhG 3797617 yfhG Shigella dysenteriae Sd197 hypothetical protein YP_404279.1 2542664 R 300267 CDS YP_404280.1 82777931 3797618 complement(2543542..2545032) 1 NC_007606.1 Code: T; COG: COG0642; 2-component sensor protein 2545032 yfhK 3797618 yfhK Shigella dysenteriae Sd197 2-component sensor protein YP_404280.1 2543542 R 300267 CDS YP_404281.1 82777932 3797619 complement(2545533..2549420) 1 NC_007606.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2549420 purL 3797619 purL Shigella dysenteriae Sd197 phosphoribosylformylglycinamidine synthase YP_404281.1 2545533 R 300267 CDS YP_404282.1 82777933 3797620 2549820..2551238 1 NC_007606.1 ''YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function''; transglycosylase 2551238 yfhD 3797620 yfhD Shigella dysenteriae Sd197 transglycosylase YP_404282.1 2549820 D 300267 CDS YP_404283.1 82777934 3797621 complement(2551235..2551771) 1 NC_007606.1 Code: FJ; COG: COG0590; tRNA-specific adenosine deaminase 2551771 yfhC 3797621 yfhC Shigella dysenteriae Sd197 tRNA-specific adenosine deaminase YP_404283.1 2551235 R 300267 CDS YP_404284.2 161950063 3797622 complement(2551796..2552431) 1 NC_007606.1 Code: E; COG: COG0560; hypothetical protein 2552431 yfhB 3797622 yfhB Shigella dysenteriae Sd197 hypothetical protein YP_404284.2 2551796 R 300267 CDS YP_404285.2 161950062 3797623 2552640..2553488 1 NC_007606.1 Code: K; COG: COG1737; DNA-binding transcriptional regulator 2553488 yfhH 3797623 yfhH Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YP_404285.2 2552640 D 300267 CDS YP_404286.1 82777937 3797624 complement(2554379..2554819) 1 NC_007606.1 Code: L; COG: COG1961; DNA-invertase 2554819 3797624 SDY_2752 Shigella dysenteriae Sd197 DNA-invertase YP_404286.1 2554379 R 300267 CDS YP_404287.1 82777938 3797625 2555309..2557135 1 NC_007606.1 Code: S; COG: COG4886; invasion plasmid antigen 2557135 ipaH_6 3797625 ipaH_6 Shigella dysenteriae Sd197 invasion plasmid antigen YP_404287.1 2555309 D 300267 CDS YP_404289.1 82777940 3797627 complement(2558149..2558451) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2558451 3797627 SDY_2755 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404289.1 2558149 R 300267 CDS YP_009000801.1 578793271 18263115 2561099..2561371 1 NC_007606.1 insertion element iso-IS1N protein InsA 2561371 18263115 SDY_4726 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000801.1 2561099 D 300267 CDS YP_404295.1 82777946 3795355 2561398..2561793 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2561793 3795355 SDY_2761 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404295.1 2561398 D 300267 CDS YP_404296.1 82777947 3795356 complement(2561768..2562136) 1 NC_007606.1 hypothetical protein 2562136 yfiL 3795356 yfiL Shigella dysenteriae Sd197 hypothetical protein YP_404296.1 2561768 R 300267 CDS YP_404297.1 82777948 3795357 2562219..2562494 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2562494 insA 3795357 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_404297.1 2562219 D 300267 CDS YP_404299.1 82777950 3795359 2563123..2564193 1 NC_007606.1 DAHP synthetase, tyrosine repressible; ''catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive''; phospho-2-dehydro-3-deoxyheptonate aldolase 2564193 aroF 3795359 aroF Shigella dysenteriae Sd197 phospho-2-dehydro-3-deoxyheptonate aldolase YP_404299.1 2563123 D 300267 CDS YP_404300.1 82777951 3795360 2564204..2565325 1 NC_007606.1 prephenate dehydrogenase; catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2565325 tyrA 3795360 tyrA Shigella dysenteriae Sd197 bifunctional chorismate mutase/prephenate dehydrogenase YP_404300.1 2564204 D 300267 CDS YP_404301.1 82777952 3795361 complement(2565368..2566528) 1 NC_007606.1 prephenate dehydratase; catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2566528 pheA 3795361 pheA Shigella dysenteriae Sd197 bifunctional chorismate mutase/prephenate dehydratase YP_404301.1 2565368 R 300267 CDS YP_404302.1 82777953 3795362 complement(2566779..2567120) 1 NC_007606.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2567120 yfiA 3795362 yfiA Shigella dysenteriae Sd197 translation inhibitor protein RaiA YP_404302.1 2566779 R 300267 CDS YP_404304.1 82777955 3795364 2569222..2569524 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2569524 3795364 SDY_2770 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404304.1 2569222 D 300267 CDS YP_404305.1 82777956 3795365 2569665..2570378 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2570378 3795365 SDY_2771 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_404305.1 2569665 D 300267 CDS YP_404306.1 82777957 3795366 2570452..2571057 1 NC_007606.1 hypothetical protein 2571057 3795366 SDY_2772 Shigella dysenteriae Sd197 hypothetical protein YP_404306.1 2570452 D 300267 CDS YP_404307.1 82777958 3795367 2571250..2571927 1 NC_007606.1 tail fiber protein 2571927 3795367 SDY_2773 Shigella dysenteriae Sd197 tail fiber protein YP_404307.1 2571250 D 300267 CDS YP_404308.1 82777959 3795368 2571971..2572381 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2572381 3795368 SDY_2774 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_404308.1 2571971 D 300267 CDS YP_404310.1 82777961 3795370 complement(2573130..2573525) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2573525 3795370 SDY_2776 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404310.1 2573130 R 300267 CDS YP_404311.1 82777962 3795371 2573720..2574028 1 NC_007606.1 hypothetical protein 2574028 3795371 SDY_2777 Shigella dysenteriae Sd197 hypothetical protein YP_404311.1 2573720 D 300267 CDS YP_404314.1 82777965 3795887 complement(2575807..2576154) 1 NC_007606.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2576154 rplS 3795887 rplS Shigella dysenteriae Sd197 50S ribosomal protein L19 YP_404314.1 2575807 R 300267 CDS YP_404315.1 82777966 3795888 complement(2576196..2576963) 1 NC_007606.1 tRNA (guanine-7-)-methyltransferase; methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2576963 trmD 3795888 trmD Shigella dysenteriae Sd197 tRNA (guanine-N(1)-)-methyltransferase YP_404315.1 2576196 R 300267 CDS YP_404316.2 161950061 3795889 complement(2576994..2577542) 1 NC_007606.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2577542 rimM 3795889 rimM Shigella dysenteriae Sd197 16S rRNA-processing protein RimM YP_404316.2 2576994 R 300267 CDS YP_404317.1 82777968 3795890 complement(2577561..2577809) 1 NC_007606.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2577809 rpsP 3795890 rpsP Shigella dysenteriae Sd197 30S ribosomal protein S16 YP_404317.1 2577561 R 300267 CDS YP_404318.1 82777969 3795891 complement(2577946..2579307) 1 NC_007606.1 binds to signal sequence, GTP and RNA; with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2579307 ffh 3795891 ffh Shigella dysenteriae Sd197 signal recognition particle protein YP_404318.1 2577946 R 300267 CDS YP_404319.1 82777970 3795892 2579399..2580265 1 NC_007606.1 Code: R; COG: COG4137; hypothetical protein 2580265 3795892 SDY_2785 Shigella dysenteriae Sd197 hypothetical protein YP_404319.1 2579399 D 300267 CDS YP_404320.2 161950060 3795893 2580376..2581572 1 NC_007606.1 Code: P; COG: COG4536; hypothetical protein 2581572 yfjD 3795893 yfjD Shigella dysenteriae Sd197 hypothetical protein YP_404320.2 2580376 D 300267 CDS YP_404321.1 82777972 3795894 complement(2581627..2582220) 1 NC_007606.1 phage lambda replication; host DNA synthesis; heat shock protein; protein repair; with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2582220 grpE 3795894 grpE Shigella dysenteriae Sd197 heat shock protein GrpE YP_404321.1 2581627 R 300267 CDS YP_404322.1 82777973 3795895 2582343..2583221 1 NC_007606.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2583221 ppnK 3795895 ppnK Shigella dysenteriae Sd197 inorganic polyphosphate/ATP-NAD kinase YP_404322.1 2582343 D 300267 CDS YP_404323.1 82777974 3795896 2583307..2584968 1 NC_007606.1 Code: L; COG: COG0497; recombination and repair protein 2584968 recN 3795896 recN Shigella dysenteriae Sd197 recombination and repair protein YP_404323.1 2583307 D 300267 CDS YP_404324.2 161950059 3795897 2585117..2585458 1 NC_007606.1 Code: J; COG: COG2913; hypothetical protein 2585458 smpA 3795897 smpA Shigella dysenteriae Sd197 hypothetical protein YP_404324.2 2585117 D 300267 CDS YP_404325.2 161950058 3795898 complement(2585520..2585810) 1 NC_007606.1 Code: S; COG: COG2914; hypothetical protein 2585810 3795898 SDY_2791 Shigella dysenteriae Sd197 hypothetical protein YP_404325.2 2585520 R 300267 CDS YP_404326.1 82777977 3795899 complement(2585800..2586276) 1 NC_007606.1 Code: I; COG: COG2867; hypothetical protein 2586276 3795899 SDY_2792 Shigella dysenteriae Sd197 hypothetical protein YP_404326.1 2585800 R 300267 CDS YP_404327.1 82777978 3795900 2586408..2586890 1 NC_007606.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2586890 smpB 3795900 smpB Shigella dysenteriae Sd197 SsrA-binding protein YP_404327.1 2586408 D 300267 CDS YP_404328.1 82777979 3795901 complement(2587628..2587840) 1 NC_007606.1 hypothetical protein 2587840 3795901 SDY_2794 Shigella dysenteriae Sd197 hypothetical protein YP_404328.1 2587628 R 300267 CDS YP_009000802.1 578793272 18263116 2590094..2590366 1 NC_007606.1 insertion element iso-IS1N protein InsA 2590366 18263116 SDY_4727 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000802.1 2590094 D 300267 CDS YP_404331.1 82777982 3795904 2590393..2590788 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2590788 3795904 SDY_2797 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404331.1 2590393 D 300267 CDS YP_404332.1 82777983 3795499 2590988..2591923 1 NC_007606.1 Code: KL; COG: COG0553; hypothetical protein 2591923 3795499 SDY_2798 Shigella dysenteriae Sd197 hypothetical protein YP_404332.1 2590988 D 300267 CDS YP_404335.1 82777986 3795502 2593728..2593988 1 NC_007606.1 Code: C; COG: COG1145; hypothetical protein 2593988 yfhL 3795502 yfhL Shigella dysenteriae Sd197 hypothetical protein YP_404335.1 2593728 D 300267 CDS YP_404336.1 82777987 3795503 complement(2594468..2594863) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2594863 3795503 SDY_2802 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404336.1 2594468 R 300267 CDS YP_009000803.1 578793273 18263117 complement(2594890..2595162) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2595162 18263117 SDY_4728 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000803.1 2594890 R 300267 CDS YP_404338.1 82777989 3795505 complement(2595458..2595838) 1 NC_007606.1 ''Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids''; 4'-phosphopantetheinyl transferase 2595838 acpS 3795505 acpS Shigella dysenteriae Sd197 4'-phosphopantetheinyl transferase YP_404338.1 2595458 R 300267 CDS YP_404339.1 82777990 3795506 complement(2595838..2596569) 1 NC_007606.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2596569 pdxJ 3795506 pdxJ Shigella dysenteriae Sd197 pyridoxine 5'-phosphate synthase YP_404339.1 2595838 R 300267 CDS YP_404340.1 82777991 3795507 complement(2596581..2597309) 1 NC_007606.1 protein interacts with RecR and possibly RecF proteins; involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2597309 recO 3795507 recO Shigella dysenteriae Sd197 DNA repair protein RecO YP_404340.1 2596581 R 300267 CDS YP_404341.1 82777992 3795508 complement(2597321..2598226) 1 NC_007606.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2598226 era 3795508 era Shigella dysenteriae Sd197 GTP-binding protein Era YP_404341.1 2597321 R 300267 CDS YP_404342.1 82777993 3795509 complement(2598223..2598903) 1 NC_007606.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2598903 rnc 3795509 rnc Shigella dysenteriae Sd197 ribonuclease III YP_404342.1 2598223 R 300267 CDS YP_404343.1 82777994 3795510 complement(2599176..2600150) 1 NC_007606.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2600150 lepB 3795510 lepB Shigella dysenteriae Sd197 signal peptidase I YP_404343.1 2599176 R 300267 CDS YP_404344.1 82777995 3795511 complement(2600166..2601965) 1 NC_007606.1 may be inner membrane protein; binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2601965 lepA 3795511 lepA Shigella dysenteriae Sd197 GTP-binding protein LepA YP_404344.1 2600166 R 300267 CDS YP_404345.1 82777996 3795512 complement(2602163..2602642) 1 NC_007606.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2602642 rseC 3795512 rseC Shigella dysenteriae Sd197 SoxR reducing system protein RseC YP_404345.1 2602163 R 300267 CDS YP_404346.1 82777997 3795513 complement(2602639..2603595) 1 NC_007606.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2603595 rseB 3795513 rseB Shigella dysenteriae Sd197 periplasmic negative regulator of sigmaE YP_404346.1 2602639 R 300267 CDS YP_404347.1 82777998 3795514 complement(2603595..2604245) 1 NC_007606.1 Code: T; COG: COG3073; anti-RNA polymerase sigma factor SigE 2604245 rseA 3795514 rseA Shigella dysenteriae Sd197 anti-RNA polymerase sigma factor SigE YP_404347.1 2603595 R 300267 CDS YP_404348.1 82777999 3795515 complement(2604278..2604853) 1 NC_007606.1 sigma-E factor; heat shock and oxidative stress; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2604853 rpoE 3795515 rpoE Shigella dysenteriae Sd197 RNA polymerase sigma factor RpoE YP_404348.1 2604278 R 300267 CDS YP_404349.1 82778000 3795516 2605261..2606883 1 NC_007606.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2606883 nadB 3795516 nadB Shigella dysenteriae Sd197 L-aspartate oxidase YP_404349.1 2605261 D 300267 CDS YP_404350.1 82778001 3795517 complement(2606868..2607725) 1 NC_007606.1 Code: R; COG: COG4123; O-methyltransferase 2607725 yfiC 3795517 yfiC Shigella dysenteriae Sd197 O-methyltransferase YP_404350.1 2606868 R 300267 CDS YP_404351.1 82778002 3795408 2607737..2609071 1 NC_007606.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2609071 srmB 3795408 srmB Shigella dysenteriae Sd197 ATP-dependent RNA helicase SrmB YP_404351.1 2607737 D 300267 CDS YP_404352.1 82778003 3795409 complement(2609104..2610030) 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2610030 yfiE 3795409 yfiE Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_404352.1 2609104 R 300267 CDS YP_404353.1 82778004 3795410 2610310..2610612 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2610612 3795410 SDY_2819 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404353.1 2610310 D 300267 CDS YP_404355.1 82778006 3795412 2611478..2611867 1 NC_007606.1 Code: E; COG: COG1280; hypothetical protein 2611867 yfiK 3795412 yfiK Shigella dysenteriae Sd197 hypothetical protein YP_404355.1 2611478 D 300267 CDS YP_404356.1 82778007 3795413 complement(2611923..2612306) 1 NC_007606.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2612306 yfiD 3795413 yfiD Shigella dysenteriae Sd197 autonomous glycyl radical cofactor GrcA YP_404356.1 2611923 R 300267 CDS YP_404357.1 82778008 3795414 2612610..2613299 1 NC_007606.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2613299 ung 3795414 ung Shigella dysenteriae Sd197 uracil-DNA glycosylase YP_404357.1 2612610 D 300267 CDS YP_404358.1 82778009 3795415 complement(2613347..2614384) 1 NC_007606.1 Code: J; COG: COG0566; methyltransferase 2614384 yfiF 3795415 yfiF Shigella dysenteriae Sd197 methyltransferase YP_404358.1 2613347 R 300267 CDS YP_404359.1 82778010 3795416 2614591..2615010 1 NC_007606.1 Code: OC; COG: COG0526; thioredoxin 2615010 trxC 3795416 trxC Shigella dysenteriae Sd197 thioredoxin YP_404359.1 2614591 D 300267 CDS YP_404360.1 82778011 3795417 2615055..2615777 1 NC_007606.1 Code: S; COG: COG3148; hypothetical protein 2615777 yfiP 3795417 yfiP Shigella dysenteriae Sd197 hypothetical protein YP_404360.1 2615055 D 300267 CDS YP_404361.1 82778012 3795418 2615809..2618469 1 NC_007606.1 Code: C; COG: COG1042; hypothetical protein 2618469 yfiQ 3795418 yfiQ Shigella dysenteriae Sd197 hypothetical protein YP_404361.1 2615809 D 300267 CDS YP_404362.1 82778013 3795419 2618580..2619938 1 NC_007606.1 phospholipid synthesis; catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2619938 pssA 3795419 pssA Shigella dysenteriae Sd197 phosphatidylserine synthase YP_404362.1 2618580 D 300267 CDS YP_404363.1 82778014 3795420 2620011..2620307 1 NC_007606.1 Code: R; COG: COG5544; hypothetical protein 2620307 yfiM 3795420 yfiM Shigella dysenteriae Sd197 hypothetical protein YP_404363.1 2620011 D 300267 CDS YP_404364.1 82778015 3795421 complement(2620304..2621602) 1 NC_007606.1 Code: GEPR; COG: COG0477; alpha-ketoglutarate transporter 2621602 kgtP 3795421 kgtP Shigella dysenteriae Sd197 alpha-ketoglutarate transporter YP_404364.1 2620304 R 300267 CDS YP_404365.1 82778016 3796209 complement(2627369..2629942) 1 NC_007606.1 Code: O; COG: COG0542; protein disaggregation chaperone 2629942 clpB 3796209 clpB Shigella dysenteriae Sd197 protein disaggregation chaperone YP_404365.1 2627369 R 300267 CDS YP_404366.1 82778017 3796210 complement(2630072..2630803) 1 NC_007606.1 Code: S; COG: COG1496; hypothetical protein 2630803 yfiH 3796210 yfiH Shigella dysenteriae Sd197 hypothetical protein YP_404366.1 2630072 R 300267 CDS YP_404367.1 82778018 3796211 complement(2630800..2631780) 1 NC_007606.1 ''responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA''; 23S rRNA pseudouridine synthase D 2631780 rluD 3796211 rluD Shigella dysenteriae Sd197 23S rRNA pseudouridine synthase D YP_404367.1 2630800 R 300267 CDS YP_404368.1 82778019 3796212 2631915..2632652 1 NC_007606.1 ''with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline''; outer membrane protein assembly complex subunit YfiO 2632652 3796212 SDY_2838 Shigella dysenteriae Sd197 outer membrane protein assembly complex subunit YfiO YP_404368.1 2631915 D 300267 CDS YP_404369.1 82778020 3796213 complement(2632703..2634049) 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 2634049 3796213 SDY_2839 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_404369.1 2632703 R 300267 CDS YP_404371.1 82778022 3796215 2634493..2634813 1 NC_007606.1 Code: L; COG: COG3436; insertion sequence element ISSfl4 ORF2 2634813 3796215 SDY_2841 Shigella dysenteriae Sd197 insertion sequence element ISSfl4 ORF2 YP_404371.1 2634493 D 300267 CDS YP_404372.1 82778023 3796216 complement(2635051..2635881) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2635881 3796216 SDY_2842 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_404372.1 2635051 R 300267 CDS YP_404373.1 82778024 3796217 complement(2636022..2636324) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2636324 3796217 SDY_2843 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404373.1 2636022 R 300267 CDS YP_009000804.1 578793274 18263118 2636520..2636681 1 NC_007606.1 hypothetical protein 2636681 18263118 SDY_2844a Shigella dysenteriae Sd197 hypothetical protein YP_009000804.1 2636520 D 300267 CDS YP_404375.1 82778026 3796219 complement(2637298..2637600) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 2637600 3796219 SDY_2845 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_404375.1 2637298 R 300267 CDS YP_404376.1 82778027 3796220 complement(2637670..2638437) 1 NC_007606.1 Code: L; COG: COG2801; hypothetical protein 2638437 3796220 SDY_2846 Shigella dysenteriae Sd197 hypothetical protein YP_404376.1 2637670 R 300267 CDS YP_404377.1 82778028 3796221 complement(2638542..2638937) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2638937 3796221 SDY_2847 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404377.1 2638542 R 300267 CDS YP_009000805.1 578793275 18263119 complement(2638964..2639236) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2639236 18263119 SDY_4729 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000805.1 2638964 R 300267 CDS YP_404378.1 82778029 3796222 complement(2639272..2639802) 1 NC_007606.1 hypothetical protein 2639802 3796222 SDY_2848 Shigella dysenteriae Sd197 hypothetical protein YP_404378.1 2639272 R 300267 CDS YP_404379.1 82778030 3796223 complement(2639839..2640216) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2640216 insB 3796223 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404379.1 2639839 R 300267 CDS YP_404380.1 82778031 3796224 complement(2640261..2640536) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2640536 insA 3796224 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404380.1 2640261 R 300267 CDS YP_404381.1 82778032 3796131 2642377..2643777 1 NC_007606.1 Code: E; COG: COG1113; gamma-aminobutyrate transporter 2643777 gabP 3796131 gabP Shigella dysenteriae Sd197 gamma-aminobutyrate transporter YP_404381.1 2642377 D 300267 CDS YP_404382.2 161950057 3796132 2643798..2644460 1 NC_007606.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2644460 ygaE 3796132 ygaE Shigella dysenteriae Sd197 DNA-binding transcriptional regulator CsiR YP_404382.2 2643798 D 300267 CDS YP_404383.1 82778034 3796133 complement(2644461..2644910) 1 NC_007606.1 Code: S; COG: COG1652; LysM domain/BON superfamily protein 2644910 ygaU 3796133 ygaU Shigella dysenteriae Sd197 LysM domain/BON superfamily protein YP_404383.1 2644461 R 300267 CDS YP_404384.1 82778035 3796134 complement(2644994..2645152) 1 NC_007606.1 Code: S; COG: COG0401; hypothetical protein 2645152 3796134 SDY_2856 Shigella dysenteriae Sd197 hypothetical protein YP_404384.1 2644994 R 300267 CDS YP_404385.1 82778036 3796135 2645335..2645634 1 NC_007606.1 Code: K; COG: COG0640; hypothetical protein 2645634 3796135 SDY_2857 Shigella dysenteriae Sd197 hypothetical protein YP_404385.1 2645335 D 300267 CDS YP_404386.1 82778037 3796136 2645644..2646162 1 NC_007606.1 Code: P; COG: COG0607; hypothetical protein 2646162 ygaP 3796136 ygaP Shigella dysenteriae Sd197 hypothetical protein YP_404386.1 2645644 D 300267 CDS YP_404387.1 82778038 3796137 complement(2646215..2646619) 1 NC_007606.1 H-NS-like protein; chaperone activity; possibly involved in RNA splicing; Code: R; COG: COG2916; DNA binding protein 2646619 stpA 3796137 stpA Shigella dysenteriae Sd197 DNA binding protein YP_404387.1 2646215 R 300267 CDS YP_404388.1 82778039 3796138 2647288..2647737 1 NC_007606.1 hypothetical protein 2647737 3796138 SDY_2860 Shigella dysenteriae Sd197 hypothetical protein YP_404388.1 2647288 D 300267 CDS YP_009000806.1 578793276 18263120 2647858..2648130 1 NC_007606.1 insertion element iso-IS1N protein InsA 2648130 18263120 SDY_4730 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000806.1 2647858 D 300267 CDS YP_404390.1 82778041 3796140 complement(2648528..2648893) 1 NC_007606.1 hypothetical protein 2648893 ygaC 3796140 ygaC Shigella dysenteriae Sd197 hypothetical protein YP_404390.1 2648528 R 300267 CDS YP_404391.1 82778042 3796141 2649033..2649374 1 NC_007606.1 Code: S; COG: COG4575; hypothetical protein 2649374 ygaM 3796141 ygaM Shigella dysenteriae Sd197 hypothetical protein YP_404391.1 2649033 D 300267 CDS YP_404392.1 82778043 3796142 complement(2649524..2650858) 1 NC_007606.1 Code: KE; COG: COG1167; transcriptional regulator 2650858 3796142 SDY_2864 Shigella dysenteriae Sd197 transcriptional regulator YP_404392.1 2649524 R 300267 CDS YP_404393.1 82778044 3796143 2650946..2651377 1 NC_007606.1 Code: S; COG: COG2128; hypothetical protein 2651377 3796143 SDY_2865 Shigella dysenteriae Sd197 hypothetical protein YP_404393.1 2650946 D 300267 CDS YP_404394.1 82778045 3796144 2651587..2651832 1 NC_007606.1 hydrogen donor; Code: O; COG: COG0695; glutaredoxin-like protein 2651832 nrdH 3796144 nrdH Shigella dysenteriae Sd197 glutaredoxin-like protein YP_404394.1 2651587 D 300267 CDS YP_404395.1 82778046 3796145 2651829..2652239 1 NC_007606.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2652239 nrdI 3796145 nrdI Shigella dysenteriae Sd197 ribonucleotide reductase stimulatory protein YP_404395.1 2651829 D 300267 CDS YP_404397.1 82778048 3796147 2654366..2655334 1 NC_007606.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2655334 nrdF 3796147 nrdF Shigella dysenteriae Sd197 ribonucleotide-diphosphate reductase subunit beta YP_404397.1 2654366 D 300267 CDS YP_404398.1 82778049 3796148 complement(2655328..2655705) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2655705 insB 3796148 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404398.1 2655328 R 300267 CDS YP_404399.1 82778050 3796149 complement(2655750..2656025) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2656025 insA 3796149 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404399.1 2655750 R 300267 CDS YP_404400.1 82778051 3799634 2656201..2657226 1 NC_007606.1 Code: E; COG: COG4175; glycine, betaine and proline ABC transporter ATP-binding protein 2657226 proV 3799634 proV Shigella dysenteriae Sd197 glycine, betaine and proline ABC transporter ATP-binding protein YP_404400.1 2656201 D 300267 CDS YP_404401.1 82778052 3799635 2657219..2658283 1 NC_007606.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2658283 proW 3799635 proW Shigella dysenteriae Sd197 glycine betaine transporter membrane protein YP_404401.1 2657219 D 300267 CDS YP_404402.1 82778053 3799636 complement(2658396..2658791) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2658791 3799636 SDY_2874 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404402.1 2658396 R 300267 CDS YP_009000807.1 578793277 18263121 complement(2658818..2659090) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2659090 18263121 SDY_4732 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000807.1 2658818 R 300267 CDS YP_404403.1 82778054 3799638 2660298..2661482 1 NC_007606.1 major facilitator superfamily; Code: GEPR; COG: COG0477; permease 2661482 3799638 SDY_2876 Shigella dysenteriae Sd197 permease YP_404403.1 2660298 D 300267 CDS YP_404404.1 82778055 3799639 2661606..2662343 1 NC_007606.1 Code: E; COG: COG1296; hypothetical protein 2662343 3799639 SDY_2877 Shigella dysenteriae Sd197 hypothetical protein YP_404404.1 2661606 D 300267 CDS YP_404405.1 82778056 3799640 2662333..2662668 1 NC_007606.1 hypothetical protein 2662668 ygaH 3799640 ygaH Shigella dysenteriae Sd197 hypothetical protein YP_404405.1 2662333 D 300267 CDS YP_404406.1 82778057 3799641 2662759..2663289 1 NC_007606.1 microcin B17 synthesis; DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2663289 emrR 3799641 emrR Shigella dysenteriae Sd197 transcriptional repressor MprA YP_404406.1 2662759 D 300267 CDS YP_404407.1 82778058 3799642 2663416..2664588 1 NC_007606.1 Code: V; COG: COG1566; multidrug resistance secretion protein 2664588 emrA 3799642 emrA Shigella dysenteriae Sd197 multidrug resistance secretion protein YP_404407.1 2663416 D 300267 CDS YP_404408.1 82778059 3799644 2666401..2667108 1 NC_007606.1 hypothetical protein 2667108 3799644 SDY_2882 Shigella dysenteriae Sd197 hypothetical protein YP_404408.1 2666401 D 300267 CDS YP_404409.1 82778060 3799645 2667174..2668217 1 NC_007606.1 Code: J; COG: COG0617; hypothetical protein 2668217 3799645 SDY_2883 Shigella dysenteriae Sd197 hypothetical protein YP_404409.1 2667174 D 300267 CDS YP_404410.1 82778061 3799646 complement(2668266..2668781) 1 NC_007606.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2668781 ygaG 3799646 ygaG Shigella dysenteriae Sd197 S-ribosylhomocysteinase YP_404410.1 2668266 R 300267 CDS YP_404411.1 82778062 3799647 complement(2668931..2670487) 1 NC_007606.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2670487 gshA 3799647 gshA Shigella dysenteriae Sd197 glutamate--cysteine ligase YP_404411.1 2668931 R 300267 CDS YP_404413.1 82778064 3799649 complement(2670984..2671550) 1 NC_007606.1 ''YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent''; fructose-1-phosphatase 2671550 yqaB 3799649 yqaB Shigella dysenteriae Sd197 fructose-1-phosphatase YP_404413.1 2670984 R 300267 CDS YP_404414.1 82778065 3796619 complement(2672733..2672918) 1 NC_007606.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2672918 csrA 3796619 csrA Shigella dysenteriae Sd197 carbon storage regulator YP_404414.1 2672733 R 300267 CDS YP_404415.1 82778066 3796620 complement(2673153..2675783) 1 NC_007606.1 ''Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; alanyl-tRNA synthetase 2675783 alaS 3796620 alaS Shigella dysenteriae Sd197 alanyl-tRNA synthetase YP_404415.1 2673153 R 300267 CDS YP_404416.1 82778067 3796621 complement(2675911..2676411) 1 NC_007606.1 regulator; binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2676411 recX 3796621 recX Shigella dysenteriae Sd197 recombination regulator RecX YP_404416.1 2675911 R 300267 CDS YP_404417.1 82778068 3796622 complement(2676654..2677715) 1 NC_007606.1 DNA strand exchange and renaturation; ''catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs''; recombinase A 2677715 recA 3796622 recA Shigella dysenteriae Sd197 recombinase A YP_404417.1 2676654 R 300267 CDS YP_404418.1 82778069 3796623 complement(2677795..2678292) 1 NC_007606.1 Code: R; COG: COG1546; competence damage-inducible protein A 2678292 ygaD 3796623 ygaD Shigella dysenteriae Sd197 competence damage-inducible protein A YP_404418.1 2677795 R 300267 CDS YP_404419.1 82778070 3796624 complement(2678438..2679523) 1 NC_007606.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2679523 mltB 3796624 mltB Shigella dysenteriae Sd197 murein hydrolase B YP_404419.1 2678438 R 300267 CDS YP_404420.1 82778071 3796625 2679779..2680342 1 NC_007606.1 one of two; Code: G; COG: COG3730; PTS system glucitol/sorbitol-specific transporter subunit IIC 2680342 srlA 3796625 srlA Shigella dysenteriae Sd197 PTS system glucitol/sorbitol-specific transporter subunit IIC YP_404420.1 2679779 D 300267 CDS YP_009000808.1 578793278 18263122 complement(2681535..2681807) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2681807 18263122 SDY_4733 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000808.1 2681535 R 300267 CDS YP_404422.1 82778073 3796628 2682083..2682454 1 NC_007606.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2682454 srlB 3796628 srlB Shigella dysenteriae Sd197 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_404422.1 2682083 D 300267 CDS YP_404423.1 82778074 3796629 2682458..2683237 1 NC_007606.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2683237 srlD 3796629 srlD Shigella dysenteriae Sd197 sorbitol-6-phosphate dehydrogenase YP_404423.1 2682458 D 300267 CDS YP_404424.1 82778075 3796630 2683343..2683702 1 NC_007606.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2683702 gutM 3796630 gutM Shigella dysenteriae Sd197 DNA-binding transcriptional activator GutM YP_404424.1 2683343 D 300267 CDS YP_404425.1 82778076 3796631 2683769..2684542 1 NC_007606.1 regulator for gut (srl) operon; regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2684542 srlR 3796631 srlR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor SrlR YP_404425.1 2683769 D 300267 CDS YP_404426.2 161950056 3796632 2684535..2685500 1 NC_007606.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2685500 gutQ 3796632 gutQ Shigella dysenteriae Sd197 D-arabinose 5-phosphate isomerase YP_404426.2 2684535 D 300267 CDS YP_404427.2 161950055 3796633 complement(2685497..2687011) 1 NC_007606.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator 2687011 ygaA 3796633 ygaA Shigella dysenteriae Sd197 anaerobic nitric oxide reductase transcriptional regulator YP_404427.2 2685497 R 300267 CDS YP_404428.1 82778079 3796383 2687198..2688637 1 NC_007606.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2688637 3796383 SDY_2907 Shigella dysenteriae Sd197 anaerobic nitric oxide reductase flavorubredoxin YP_404428.1 2687198 D 300267 CDS YP_404429.1 82778080 3796384 2688634..2689767 1 NC_007606.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2689767 ygbD 3796384 ygbD Shigella dysenteriae Sd197 nitric oxide reductase YP_404429.1 2688634 D 300267 CDS YP_404430.1 82778081 3796385 complement(2689899..2692151) 1 NC_007606.1 Code: O; COG: COG0068; transcriptional regulator 2692151 hypF 3796385 hypF Shigella dysenteriae Sd197 transcriptional regulator YP_404430.1 2689899 R 300267 CDS YP_404431.1 82778082 3796387 complement(2692712..2693725) 1 NC_007606.1 Code: K; COG: COG1609; ascBF operon repressor 2693725 ascG 3796387 ascG Shigella dysenteriae Sd197 ascBF operon repressor YP_404431.1 2692712 R 300267 CDS YP_404432.1 82778083 3796388 2694840..2696264 1 NC_007606.1 cryptic protein; Code: G; COG: COG2723; cryptic 6-phospho-beta-glucosidase 2696264 ascB 3796388 ascB Shigella dysenteriae Sd197 cryptic 6-phospho-beta-glucosidase YP_404432.1 2694840 D 300267 CDS YP_404433.1 82778084 3796389 complement(2696379..2696864) 1 NC_007606.1 Code: K; COG: COG5499; hypothetical protein 2696864 3796389 SDY_2913 Shigella dysenteriae Sd197 hypothetical protein YP_404433.1 2696379 R 300267 CDS YP_404434.1 82778085 3796390 complement(2697034..2697501) 1 NC_007606.1 protease involved in processing C-terminal end of the large subunit of hydrogenase 3; involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 2697501 hycI 3796390 hycI Shigella dysenteriae Sd197 hydrogenase 3 maturation protease YP_404434.1 2697034 R 300267 CDS YP_404435.1 82778086 3796391 complement(2697494..2697904) 1 NC_007606.1 processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex); formate hydrogenlyase maturation protein HycH 2697904 hycH 3796391 hycH Shigella dysenteriae Sd197 formate hydrogenlyase maturation protein HycH YP_404435.1 2697494 R 300267 CDS YP_404436.1 82778087 3796393 complement(2698667..2699209) 1 NC_007606.1 part of FHL complex; ''electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate''; formate hydrogenlyase complex iron-sulfur subunit 2699209 hycF 3796393 hycF Shigella dysenteriae Sd197 formate hydrogenlyase complex iron-sulfur subunit YP_404436.1 2698667 R 300267 CDS YP_404437.1 82778088 3796394 complement(2699219..2700928) 1 NC_007606.1 part of FHL complex; Code: C; COG: COG3261; hydrogenase 3 large subunit 2700928 hycE 3796394 hycE Shigella dysenteriae Sd197 hydrogenase 3 large subunit YP_404437.1 2699219 R 300267 CDS YP_404439.1 82778090 3796397 complement(2703737..2704348) 1 NC_007606.1 part of formate hydrogenlyase (FHL) complex; Code: C; COG: COG1142; hydrogenase-3 iron-sulfur small subunit 2704348 hycB 3796397 hycB Shigella dysenteriae Sd197 hydrogenase-3 iron-sulfur small subunit YP_404439.1 2703737 R 300267 CDS YP_404440.1 82778091 3796398 complement(2704473..2704934) 1 NC_007606.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 2704934 hycA 3796398 hycA Shigella dysenteriae Sd197 formate hydrogenlyase regulatory protein HycA YP_404440.1 2704473 R 300267 CDS YP_404441.1 82778092 3796399 2705146..2705496 1 NC_007606.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2705496 hypA 3796399 hypA Shigella dysenteriae Sd197 hydrogenase nickel incorporation protein YP_404441.1 2705146 D 300267 CDS YP_404442.1 82778093 3796400 2705500..2706372 1 NC_007606.1 functions as nickel donor for large subunit of hydrogenase 3; GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2706372 hypB 3796400 hypB Shigella dysenteriae Sd197 hydrogenase nickel incorporation protein HypB YP_404442.1 2705500 D 300267 CDS YP_404443.1 82778094 3796401 2706363..2706635 1 NC_007606.1 ''HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase''; hydrogenase assembly chaperone 2706635 hypC 3796401 hypC Shigella dysenteriae Sd197 hydrogenase assembly chaperone YP_404443.1 2706363 D 300267 CDS YP_404444.1 82778095 3796402 2706635..2707756 1 NC_007606.1 Code: O; COG: COG0409; hydrogenase expression/formation protein HypD 2707756 hypD 3796402 hypD Shigella dysenteriae Sd197 hydrogenase expression/formation protein HypD YP_404444.1 2706635 D 300267 CDS YP_404445.1 82778096 3796501 2707795..2708763 1 NC_007606.1 plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309; hypothetical protein 2708763 hypE 3796501 hypE Shigella dysenteriae Sd197 hypothetical protein YP_404445.1 2707795 D 300267 CDS YP_404446.1 82778097 3796503 complement(2710642..2711355) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2711355 3796503 SDY_2929 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_404446.1 2710642 R 300267 CDS YP_404447.1 82778098 3796504 complement(2711496..2711798) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2711798 3796504 SDY_2930 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404447.1 2711496 R 300267 CDS YP_404448.1 82778099 3796505 2712202..2712645 1 NC_007606.1 Code: R; COG: COG2005; molybdenum-pterin-binding-protein 2712645 3796505 SDY_2931 Shigella dysenteriae Sd197 molybdenum-pterin-binding-protein YP_404448.1 2712202 D 300267 CDS YP_404449.1 82778100 3796506 complement(2712684..2713028) 1 NC_007606.1 hypothetical protein 2713028 ygbA 3796506 ygbA Shigella dysenteriae Sd197 hypothetical protein YP_404449.1 2712684 R 300267 CDS YP_404450.1 82778101 3796507 2713315..2715876 1 NC_007606.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2715876 mutS 3796507 mutS Shigella dysenteriae Sd197 DNA mismatch repair protein MutS YP_404450.1 2713315 D 300267 CDS YP_404451.1 82778102 3796508 complement(2715940..2716317) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2716317 insB 3796508 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404451.1 2715940 R 300267 CDS YP_404452.1 82778103 3796509 complement(2716362..2716637) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2716637 insA 3796509 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404452.1 2716362 R 300267 CDS YP_404453.1 82778104 3796510 complement(2716734..2716970) 1 NC_007606.1 hypothetical protein 2716970 3796510 SDY_2936 Shigella dysenteriae Sd197 hypothetical protein YP_404453.1 2716734 R 300267 CDS YP_404455.1 82778106 3796512 complement(2718407..2719000) 1 NC_007606.1 Code: H; COG: COG0163; phenylacrylic acid decarboxylase-like protein 2719000 3796512 SDY_2938 Shigella dysenteriae Sd197 phenylacrylic acid decarboxylase-like protein YP_404455.1 2718407 R 300267 CDS YP_404456.1 82778107 3796513 2719147..2719554 1 NC_007606.1 Code: K; COG: COG1846; transcriptional regulator 2719554 3796513 SDY_2939 Shigella dysenteriae Sd197 transcriptional regulator YP_404456.1 2719147 D 300267 CDS YP_404457.1 82778108 3796514 complement(2719674..2720666) 1 NC_007606.1 sigma38 factor; synthesis of many growth phase related proteins; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 2720666 rpoS 3796514 rpoS Shigella dysenteriae Sd197 RNA polymerase sigma factor RpoS YP_404457.1 2719674 R 300267 CDS YP_404458.1 82778109 3796515 complement(2720729..2721868) 1 NC_007606.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 2721868 nlpD 3796515 nlpD Shigella dysenteriae Sd197 lipoprotein NlpD YP_404458.1 2720729 R 300267 CDS YP_404459.1 82778110 3796516 complement(2722008..2722634) 1 NC_007606.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 2722634 pcm 3796516 pcm Shigella dysenteriae Sd197 protein-L-isoaspartate O-methyltransferase YP_404459.1 2722008 R 300267 CDS YP_404460.1 82778111 3796517 complement(2722628..2723389) 1 NC_007606.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2723389 surE 3796517 surE Shigella dysenteriae Sd197 stationary phase survival protein SurE YP_404460.1 2722628 R 300267 CDS YP_404461.1 82778112 3796518 complement(2723370..2724419) 1 NC_007606.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2724419 truD 3796518 truD Shigella dysenteriae Sd197 tRNA pseudouridine synthase D YP_404461.1 2723370 R 300267 CDS YP_404462.1 82778113 3796519 complement(2724416..2724895) 1 NC_007606.1 ''catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate''; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2724895 ispF 3796519 ispF Shigella dysenteriae Sd197 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_404462.1 2724416 R 300267 CDS YP_404463.1 82778114 3796403 complement(2724895..2725605) 1 NC_007606.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2725605 ispD 3796403 ispD Shigella dysenteriae Sd197 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_404463.1 2724895 R 300267 CDS YP_404464.1 82778115 3796404 complement(2725624..2725935) 1 NC_007606.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 2725935 ftsB 3796404 ftsB Shigella dysenteriae Sd197 cell division protein FtsB YP_404464.1 2725624 R 300267 CDS YP_404465.1 82778116 3796405 complement(2726129..2726452) 1 NC_007606.1 hypothetical protein 2726452 ygbE 3796405 ygbE Shigella dysenteriae Sd197 hypothetical protein YP_404465.1 2726129 R 300267 CDS YP_404466.1 82778117 3796406 complement(2726502..2727107) 1 NC_007606.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 2727107 cysC 3796406 cysC Shigella dysenteriae Sd197 adenylylsulfate kinase YP_404466.1 2726502 R 300267 CDS YP_404467.1 82778118 3796407 complement(2727107..2728534) 1 NC_007606.1 ATP:sulfate adenylyltransferase; probably a GTPase; may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 2728534 cysN 3796407 cysN Shigella dysenteriae Sd197 sulfate adenylyltransferase subunit 1 YP_404467.1 2727107 R 300267 CDS YP_404468.1 82778119 3796408 complement(2728536..2729444) 1 NC_007606.1 ATP:sulfate adenylyltransferase; probably a GTPase; with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2729444 cysD 3796408 cysD Shigella dysenteriae Sd197 sulfate adenylyltransferase subunit 2 YP_404468.1 2728536 R 300267 CDS YP_404469.1 82778120 3796409 2729697..2730734 1 NC_007606.1 alkaline phosphatase isozyme conversion; catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 2730734 iap 3796409 iap Shigella dysenteriae Sd197 alkaline phosphatase YP_404469.1 2729697 D 300267 CDS YP_404470.2 161950054 3796410 complement(2731133..2731417) 1 NC_007606.1 hypothetical protein 2731417 ygbF 3796410 ygbF Shigella dysenteriae Sd197 hypothetical protein YP_404470.2 2731133 R 300267 CDS YP_404472.1 82778123 3796412 complement(2732352..2732951) 1 NC_007606.1 hypothetical protein 2732951 3796412 SDY_2955 Shigella dysenteriae Sd197 hypothetical protein YP_404472.1 2732352 R 300267 CDS YP_404473.1 82778124 3796413 2733329..2733604 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2733604 insA 3796413 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404473.1 2733329 D 300267 CDS YP_404474.1 82778125 3796414 2733649..2734026 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2734026 insB 3796414 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404474.1 2733649 D 300267 CDS YP_404477.1 82778128 3796417 2735185..2735487 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2735487 3796417 SDY_2960 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404477.1 2735185 D 300267 CDS YP_404478.1 82778129 3796418 2735628..2736440 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2736440 3796418 SDY_2961 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_404478.1 2735628 D 300267 CDS YP_404479.1 82778130 3796419 complement(2736469..2736846) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2736846 insB 3796419 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404479.1 2736469 R 300267 CDS YP_404480.1 82778131 3796420 complement(2736891..2737166) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2737166 insA 3796420 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404480.1 2736891 R 300267 CDS YP_404481.1 82778132 3796421 complement(2737233..2737967) 1 NC_007606.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2737967 cysH 3796421 cysH Shigella dysenteriae Sd197 phosphoadenosine phosphosulfate reductase YP_404481.1 2737233 R 300267 CDS YP_404482.1 82778133 3796422 complement(2738041..2739753) 1 NC_007606.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2739753 cysI 3796422 cysI Shigella dysenteriae Sd197 sulfite reductase subunit beta YP_404482.1 2738041 R 300267 CDS YP_404483.1 82778134 3798041 complement(2739753..2741552) 1 NC_007606.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 2741552 cysJ 3798041 cysJ Shigella dysenteriae Sd197 sulfite reductase subunit alpha YP_404483.1 2739753 R 300267 CDS YP_404484.1 82778135 3798042 2741868..2742233 1 NC_007606.1 Code: H; COG: COG0720; 6-pyruvoyl tetrahydrobiopterin synthase 2742233 ygcM 3798042 ygcM Shigella dysenteriae Sd197 6-pyruvoyl tetrahydrobiopterin synthase YP_404484.1 2741868 D 300267 CDS YP_404485.1 82778136 3798043 2742281..2743582 1 NC_007606.1 Code: C; COG: COG0644; hypothetical protein 2743582 ygcN 3798043 ygcN Shigella dysenteriae Sd197 hypothetical protein YP_404485.1 2742281 D 300267 CDS YP_404486.1 82778137 3798044 2743537..2743833 1 NC_007606.1 Code: C; COG: COG2440; hypothetical protein 2743833 ygcO 3798044 ygcO Shigella dysenteriae Sd197 hypothetical protein YP_404486.1 2743537 D 300267 CDS YP_404487.1 82778138 3798045 2743850..2744425 1 NC_007606.1 Code: K; COG: COG1954; anti-terminator regulatory protein 2744425 ygcP 3798045 ygcP Shigella dysenteriae Sd197 anti-terminator regulatory protein YP_404487.1 2743850 D 300267 CDS YP_404488.1 82778139 3798048 complement(2746187..2747596) 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 2747596 ygcS 3798048 ygcS Shigella dysenteriae Sd197 transport protein YP_404488.1 2746187 R 300267 CDS YP_404490.1 82778141 3798050 complement(2749115..2749510) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2749510 3798050 SDY_2975 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404490.1 2749115 R 300267 CDS YP_009000809.1 578793279 18263123 complement(2749537..2749809) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2749809 18263123 SDY_4734 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000809.1 2749537 R 300267 CDS YP_404491.1 82778142 3798051 complement(2749916..2750701) 1 NC_007606.1 Code: IQR; COG: COG1028; oxidoreductase 2750701 ygcW 3798051 ygcW Shigella dysenteriae Sd197 oxidoreductase YP_404491.1 2749916 R 300267 CDS YP_404492.1 82778143 3798053 2752322..2753800 1 NC_007606.1 Code: G; COG: COG1070; kinase 2753800 ygcE 3798053 ygcE Shigella dysenteriae Sd197 kinase YP_404492.1 2752322 D 300267 CDS YP_404493.2 161950053 3798054 complement(2753973..2754878) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2754878 3798054 SDY_2979 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_404493.2 2753973 R 300267 CDS YP_404494.1 82778145 3798055 complement(2754836..2755201) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 2755201 3798055 SDY_2980 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_404494.1 2754836 R 300267 CDS YP_404495.1 82778146 3798056 complement(2755549..2756220) 1 NC_007606.1 Code: O; COG: COG0602; hypothetical protein 2756220 ygcF 3798056 ygcF Shigella dysenteriae Sd197 hypothetical protein YP_404495.1 2755549 R 300267 CDS YP_009000810.1 578793280 18263124 2756464..2756736 1 NC_007606.1 insertion element iso-IS1N protein InsA 2756736 18263124 SDY_4735 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000810.1 2756464 D 300267 CDS YP_404497.1 82778148 3798058 2756763..2757158 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2757158 3798058 SDY_2983 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404497.1 2756763 D 300267 CDS YP_404500.1 82778151 3797388 complement(2757727..2758122) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2758122 3797388 SDY_2986 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404500.1 2757727 R 300267 CDS YP_009000811.1 578793281 18263125 complement(2758149..2758421) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2758421 18263125 SDY_4736 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000811.1 2758149 R 300267 CDS YP_404501.1 82778152 3797389 2758535..2758837 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2758837 3797389 SDY_2987 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404501.1 2758535 D 300267 CDS YP_404504.1 82778155 3797392 complement(2760150..2760452) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2760452 3797392 SDY_2990 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404504.1 2760150 R 300267 CDS YP_404506.1 82778157 3797394 2760757..2761467 1 NC_007606.1 Code: R; COG: COG1512; hypothetical protein 2761467 3797394 SDY_2992 Shigella dysenteriae Sd197 hypothetical protein YP_404506.1 2760757 D 300267 CDS YP_404507.1 82778158 3797395 complement(2761461..2761838) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2761838 insB 3797395 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404507.1 2761461 R 300267 CDS YP_404508.1 82778159 3797396 complement(2761883..2762158) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2762158 insA 3797396 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404508.1 2761883 R 300267 CDS YP_404509.1 82778160 3797397 2762297..2762563 1 NC_007606.1 hypothetical protein 2762563 3797397 SDY_2995 Shigella dysenteriae Sd197 hypothetical protein YP_404509.1 2762297 D 300267 CDS YP_404510.1 82778161 3797398 complement(2762623..2763921) 1 NC_007606.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 2763921 eno 3797398 eno Shigella dysenteriae Sd197 phosphopyruvate hydratase YP_404510.1 2762623 R 300267 CDS YP_404511.1 82778162 3797399 complement(2764009..2765646) 1 NC_007606.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 2765646 pyrG 3797399 pyrG Shigella dysenteriae Sd197 CTP synthetase YP_404511.1 2764009 R 300267 CDS YP_404512.1 82778163 3797400 complement(2765869..2766660) 1 NC_007606.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 2766660 mazG 3797400 mazG Shigella dysenteriae Sd197 nucleoside triphosphate pyrophosphohydrolase YP_404512.1 2765869 R 300267 CDS YP_404513.1 82778164 3797401 complement(2766731..2767066) 1 NC_007606.1 autoregulated; MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 2767066 chpA 3797401 chpA Shigella dysenteriae Sd197 toxin ChpA YP_404513.1 2766731 R 300267 CDS YP_404514.1 82778165 3797402 complement(2767066..2767314) 1 NC_007606.1 autoregulated; part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 2767314 chpR 3797402 chpR Shigella dysenteriae Sd197 antitoxin MazE YP_404514.1 2767066 R 300267 CDS YP_404515.1 82778166 3797403 complement(2767392..2769626) 1 NC_007606.1 GTP pyrophosphokinase; regulation of RNA synthesis; stringent factor; (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 2769626 relA 3797403 relA Shigella dysenteriae Sd197 GDP/GTP pyrophosphokinase YP_404515.1 2767392 R 300267 CDS YP_404516.1 82778167 3797404 complement(2769674..2770975) 1 NC_007606.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 2770975 rumA 3797404 rumA Shigella dysenteriae Sd197 23S rRNA 5-methyluridine methyltransferase YP_404516.1 2769674 R 300267 CDS YP_404517.1 82778168 3797405 2771032..2773788 1 NC_007606.1 activates OmpR by phophorylation; part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2773788 barA 3797405 barA Shigella dysenteriae Sd197 hybrid sensory histidine kinase BarA YP_404517.1 2771032 D 300267 CDS YP_404518.1 82778169 3796346 complement(2778498..2778947) 1 NC_007606.1 ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''; flavodoxin 2778947 3796346 SDY_3007 Shigella dysenteriae Sd197 flavodoxin YP_404518.1 2778498 R 300267 CDS YP_404519.1 82778170 3796347 complement(2778965..2779747) 1 NC_007606.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 2779747 yqcB 3796347 yqcB Shigella dysenteriae Sd197 tRNA pseudouridine synthase C YP_404519.1 2778965 R 300267 CDS YP_404520.1 82778171 3796348 complement(2779747..2780076) 1 NC_007606.1 Code: S; COG: COG3098; hypothetical protein 2780076 3796348 SDY_3009 Shigella dysenteriae Sd197 hypothetical protein YP_404520.1 2779747 R 300267 CDS YP_404521.1 82778172 3796349 complement(2780698..2781243) 1 NC_007606.1 interacts with secY; SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 2781243 syd 3796349 syd Shigella dysenteriae Sd197 SecY interacting protein Syd YP_404521.1 2780698 R 300267 CDS YP_404522.1 82778173 3796350 2781311..2782159 1 NC_007606.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2782159 queF 3796350 queF Shigella dysenteriae Sd197 7-cyano-7-deazaguanine reductase YP_404522.1 2781311 D 300267 CDS YP_404523.1 82778174 3796351 2782271..2783635 1 NC_007606.1 Code: R; COG: COG1611; hypothetical protein 2783635 ygdH 3796351 ygdH Shigella dysenteriae Sd197 hypothetical protein YP_404523.1 2782271 D 300267 CDS YP_404524.1 82778175 3796352 2784192..2785481 1 NC_007606.1 Code: E; COG: COG0814; serine transporter 2785481 sdaC 3796352 sdaC Shigella dysenteriae Sd197 serine transporter YP_404524.1 2784192 D 300267 CDS YP_404525.1 82778176 3796353 2785539..2786906 1 NC_007606.1 deaminase, L-SD2; Code: E; COG: COG1760; L-serine dehydratase 2786906 sdaB 3796353 sdaB Shigella dysenteriae Sd197 L-serine dehydratase YP_404525.1 2785539 D 300267 CDS YP_404526.1 82778177 3796354 2786928..2787773 1 NC_007606.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2787773 xni 3796354 xni Shigella dysenteriae Sd197 exonuclease IX YP_404526.1 2786928 D 300267 CDS YP_404527.1 82778178 3796355 complement(2787828..2788979) 1 NC_007606.1 Code: C; COG: COG1454; L-1,2-propanediol oxidoreductase 2788979 fucO 3796355 fucO Shigella dysenteriae Sd197 L-1,2-propanediol oxidoreductase YP_404527.1 2787828 R 300267 CDS YP_404528.1 82778179 3796356 complement(2789004..2789651) 1 NC_007606.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 2789651 fucA 3796356 fucA Shigella dysenteriae Sd197 L-fuculose phosphate aldolase YP_404528.1 2789004 R 300267 CDS YP_404529.1 82778180 3796358 2791116..2791511 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2791511 3796358 SDY_3019 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404529.1 2791116 D 300267 CDS YP_404530.1 82778181 3796359 2792322..2794097 1 NC_007606.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2794097 fucI 3796359 fucI Shigella dysenteriae Sd197 L-fucose isomerase YP_404530.1 2792322 D 300267 CDS YP_404531.1 82778182 3796360 2794176..2795624 1 NC_007606.1 Code: G; COG: COG1070; L-fuculokinase 2795624 fucK 3796360 fucK Shigella dysenteriae Sd197 L-fuculokinase YP_404531.1 2794176 D 300267 CDS YP_404532.1 82778183 3796361 2795626..2796048 1 NC_007606.1 Code: G; COG: COG4154; L-fucose mutarotase 2796048 fucU 3796361 fucU Shigella dysenteriae Sd197 L-fucose mutarotase YP_404532.1 2795626 D 300267 CDS YP_404533.1 82778184 3796362 2796106..2796837 1 NC_007606.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2796837 fucR 3796362 fucR Shigella dysenteriae Sd197 DNA-binding transcriptional activator FucR YP_404533.1 2796106 D 300267 CDS YP_404534.1 82778185 3796113 complement(2796881..2797981) 1 NC_007606.1 Code: R; COG: COG2933; RNA 2'-O-ribose methyltransferase 2797981 ygdE 3796113 ygdE Shigella dysenteriae Sd197 RNA 2'-O-ribose methyltransferase YP_404534.1 2796881 R 300267 CDS YP_404535.1 82778186 3796114 complement(2797974..2798369) 1 NC_007606.1 Code: S; COG: COG2363; hypothetical protein 2798369 ygdD 3796114 ygdD Shigella dysenteriae Sd197 hypothetical protein YP_404535.1 2797974 R 300267 CDS YP_404536.1 82778187 3796115 complement(2798388..2799305) 1 NC_007606.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 2799305 gcvA 3796115 gcvA Shigella dysenteriae Sd197 DNA-binding transcriptional activator GcvA YP_404536.1 2798388 R 300267 CDS YP_404537.1 82778188 3796116 complement(2799656..2799886) 1 NC_007606.1 hypothetical protein 2799886 3796116 SDY_3027 Shigella dysenteriae Sd197 hypothetical protein YP_404537.1 2799656 R 300267 CDS YP_404538.1 82778189 3796117 2800075..2801280 1 NC_007606.1 Code: E; COG: COG0520; cysteine sulfinate desulfinase 2801280 3796117 SDY_3028 Shigella dysenteriae Sd197 cysteine sulfinate desulfinase YP_404538.1 2800075 D 300267 CDS YP_404539.1 82778190 3796118 2801280..2801723 1 NC_007606.1 Code: R; COG: COG2166; hypothetical protein 2801723 ygdK 3796118 ygdK Shigella dysenteriae Sd197 hypothetical protein YP_404539.1 2801280 D 300267 CDS YP_404540.1 82778191 3796119 complement(2801774..2802580) 1 NC_007606.1 Code: H; COG: COG1179; sulfur acceptor protein CsdL 2802580 ygdL 3796119 ygdL Shigella dysenteriae Sd197 sulfur acceptor protein CsdL YP_404540.1 2801774 R 300267 CDS YP_404541.1 82778192 3796120 complement(2802819..2803916) 1 NC_007606.1 ''membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues''; murein transglycosylase A 2803916 mltA 3796120 mltA Shigella dysenteriae Sd197 murein transglycosylase A YP_404541.1 2802819 R 300267 CDS YP_404542.1 82778193 3796123 complement(2804385..2805728) 1 NC_007606.1 Code: M; COG: COG0860; amidase 2805728 3796123 SDY_3034 Shigella dysenteriae Sd197 amidase YP_404542.1 2804385 R 300267 CDS YP_404543.1 82778194 3796124 2805870..2807201 1 NC_007606.1 amino acid acetyltransferase; catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 2807201 argA 3796124 argA Shigella dysenteriae Sd197 N-acetylglutamate synthase YP_404543.1 2805870 D 300267 CDS YP_404544.1 82778195 3796125 complement(2807263..2809089) 1 NC_007606.1 DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 2809089 recD 3796125 recD Shigella dysenteriae Sd197 exonuclease V subunit alpha YP_404544.1 2807263 R 300267 CDS YP_404545.1 82778196 3796126 complement(2809089..2812631) 1 NC_007606.1 DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 2812631 recB 3796126 recB Shigella dysenteriae Sd197 exonuclease V subunit beta YP_404545.1 2809089 R 300267 CDS YP_404546.1 82778197 3796127 complement(2812624..2815512) 1 NC_007606.1 Code: O; COG: COG1025; protease III 2815512 ptr 3796127 ptr Shigella dysenteriae Sd197 protease III YP_404546.1 2812624 R 300267 CDS YP_404547.1 82778198 3796128 complement(2815688..2819056) 1 NC_007606.1 DNA helicase; ssDNA endonuclease; catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 2819056 recC 3796128 recC Shigella dysenteriae Sd197 exonuclease V subunit gamma YP_404547.1 2815688 R 300267 CDS YP_404548.1 82778199 3796129 complement(2819069..2819392) 1 NC_007606.1 Code: NU; COG: COG4967; hypothetical protein 2819392 ppdC 3796129 ppdC Shigella dysenteriae Sd197 hypothetical protein YP_404548.1 2819069 R 300267 CDS YP_404549.2 161950052 3796130 complement(2819377..2819784) 1 NC_007606.1 hypothetical protein 2819784 ygdB 3796130 ygdB Shigella dysenteriae Sd197 hypothetical protein YP_404549.2 2819377 R 300267 CDS YP_404550.1 82778201 3795925 complement(2819781..2820344) 1 NC_007606.1 Code: U; COG: COG4795; hypothetical protein 2820344 ppdB 3795925 ppdB Shigella dysenteriae Sd197 hypothetical protein YP_404550.1 2819781 R 300267 CDS YP_404551.1 82778202 3795926 complement(2820335..2820805) 1 NC_007606.1 Code: NU; COG: COG2165; hypothetical protein 2820805 ppdA 3795926 ppdA Shigella dysenteriae Sd197 hypothetical protein YP_404551.1 2820335 R 300267 CDS YP_404552.1 82778203 3795927 complement(2820990..2821784) 1 NC_007606.1 ''ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived''; thymidylate synthase 2821784 thyA 3795927 thyA Shigella dysenteriae Sd197 thymidylate synthase YP_404552.1 2820990 R 300267 CDS YP_404553.1 82778204 3795928 complement(2821791..2822666) 1 NC_007606.1 a major membrane phospholipid; transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 2822666 lgt 3795928 lgt Shigella dysenteriae Sd197 prolipoprotein diacylglyceryl transferase YP_404553.1 2821791 R 300267 CDS YP_404554.1 82778205 3795929 complement(2822818..2825064) 1 NC_007606.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 2825064 ptsP 3795929 ptsP Shigella dysenteriae Sd197 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_404554.1 2822818 R 300267 CDS YP_404555.1 82778206 3795930 complement(2825077..2825607) 1 NC_007606.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 2825607 ygdP 3795930 ygdP Shigella dysenteriae Sd197 dinucleoside polyphosphate hydrolase YP_404555.1 2825077 R 300267 CDS YP_404556.1 82778207 3795931 2826292..2826981 1 NC_007606.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 2826981 mutH 3795931 mutH Shigella dysenteriae Sd197 DNA mismatch repair protein YP_404556.1 2826292 D 300267 CDS YP_404557.1 82778208 3795932 2827050..2827763 1 NC_007606.1 Code: P; COG: COG0861; transport protein 2827763 3795932 SDY_3049 Shigella dysenteriae Sd197 transport protein YP_404557.1 2827050 D 300267 CDS YP_404558.1 82778209 3795933 2827901..2828119 1 NC_007606.1 hypothetical protein 2828119 3795933 SDY_3050 Shigella dysenteriae Sd197 hypothetical protein YP_404558.1 2827901 D 300267 CDS YP_404559.1 82778210 3795934 2828227..2829267 1 NC_007606.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 2829267 tas 3795934 tas Shigella dysenteriae Sd197 aldo-keto reductase YP_404559.1 2828227 D 300267 CDS YP_404560.1 82778211 3795935 complement(2829299..2830492) 1 NC_007606.1 Code: GEPR; COG: COG0477; lysophospholipid transporter LplT 2830492 ygeD 3795935 ygeD Shigella dysenteriae Sd197 lysophospholipid transporter LplT YP_404560.1 2829299 R 300267 CDS YP_404561.1 82778212 3795936 complement(2830485..2832644) 1 NC_007606.1 acyl-acyl-carrier protein synthetase; Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 2832644 aas 3795936 aas Shigella dysenteriae Sd197 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_404561.1 2830485 R 300267 CDS YP_404562.1 82778213 3795937 2833230..2834261 1 NC_007606.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 2834261 galR 3795937 galR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator GalR YP_404562.1 2833230 D 300267 CDS YP_404563.1 82778214 3795938 complement(2834268..2835530) 1 NC_007606.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 2835530 lysA 3795938 lysA Shigella dysenteriae Sd197 diaminopimelate decarboxylase YP_404563.1 2834268 R 300267 CDS YP_404564.1 82778215 3795939 2835652..2836587 1 NC_007606.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 2836587 lysR 3795939 lysR Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_404564.1 2835652 D 300267 CDS YP_404565.1 82778216 3795940 complement(2836574..2837257) 1 NC_007606.1 Code: M; COG: COG1794; racemase 2837257 ygeA 3795940 ygeA Shigella dysenteriae Sd197 racemase YP_404565.1 2836574 R 300267 CDS YP_404566.1 82778217 3795941 complement(2837386..2838615) 1 NC_007606.1 Code: GEPR; COG: COG0477; low-affinity L-arabinose transport system proton symport protein 2838615 araE 3795941 araE Shigella dysenteriae Sd197 low-affinity L-arabinose transport system proton symport protein YP_404566.1 2837386 R 300267 CDS YP_404567.1 82778218 3795942 complement(2838863..2839240) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2839240 insB 3795942 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404567.1 2838863 R 300267 CDS YP_404568.1 82778219 3795943 complement(2839285..2839560) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2839560 insA 3795943 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_404568.1 2839285 R 300267 CDS YP_404569.2 161950051 3796059 complement(2839759..2840586) 1 NC_007606.1 ''methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate''; 2,5-diketo-D-gluconate reductase A 2840586 dkgA 3796059 dkgA Shigella dysenteriae Sd197 2,5-diketo-D-gluconate reductase A YP_404569.2 2839759 R 300267 CDS YP_404570.1 82778222 3796061 complement(2840691..2841854) 1 NC_007606.1 Code: C; COG: COG1979; oxidoreductase 2841854 yqhD 3796061 yqhD Shigella dysenteriae Sd197 oxidoreductase YP_404570.1 2840691 R 300267 CDS YP_404571.1 82778221 3796060 2841820..2842947 1 NC_007606.1 Code: K; COG: COG2207; AraC family transcriptional regulator 2842947 yqhC 3796060 yqhC Shigella dysenteriae Sd197 AraC family transcriptional regulator YP_404571.1 2841820 D 300267 CDS YP_404572.1 82778223 3796062 complement(2842987..2843646) 1 NC_007606.1 Code: S; COG: COG0586; hypothetical protein 2843646 yghB 3796062 yghB Shigella dysenteriae Sd197 hypothetical protein YP_404572.1 2842987 R 300267 CDS YP_404573.1 82778224 3796063 complement(2843787..2844974) 1 NC_007606.1 beta-cystathionase; catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 2844974 metC 3796063 metC Shigella dysenteriae Sd197 cystathionine beta-lyase YP_404573.1 2843787 R 300267 CDS YP_404574.1 82778225 3796064 2845078..2845233 1 NC_007606.1 hypothetical protein 2845233 3796064 SDY_3066 Shigella dysenteriae Sd197 hypothetical protein YP_404574.1 2845078 D 300267 CDS YP_404575.1 82778226 3796065 2845226..2845960 1 NC_007606.1 uptake of enterochelin; tonB-dependent uptake of B colicins; membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 2845960 exbB 3796065 exbB Shigella dysenteriae Sd197 biopolymer transport protein ExbB YP_404575.1 2845226 D 300267 CDS YP_404576.1 82778227 3796066 2845967..2846392 1 NC_007606.1 uptake of enterochelin; tonB-dependent uptake of B colicins; membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 2846392 exbD 3796066 exbD Shigella dysenteriae Sd197 biopolymer transport protein ExbD YP_404576.1 2845967 D 300267 CDS YP_404577.1 82778228 3796067 complement(2846431..2847315) 1 NC_007606.1 Code: IQR; COG: COG1028; oxidoreductase 2847315 yghA 3796067 yghA Shigella dysenteriae Sd197 oxidoreductase YP_404577.1 2846431 R 300267 CDS YP_404578.1 82778229 3796068 2847506..2848000 1 NC_007606.1 Code: S; COG: COG2862; hypothetical protein 2848000 yqhA 3796068 yqhA Shigella dysenteriae Sd197 hypothetical protein YP_404578.1 2847506 D 300267 CDS YP_404579.1 82778230 3796069 complement(2848300..2848677) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2848677 insB 3796069 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404579.1 2848300 R 300267 CDS YP_404580.1 82778231 3796070 complement(2848722..2848997) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2848997 insA 3796070 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404580.1 2848722 R 300267 CDS YP_404581.1 82778232 3796071 complement(2849048..2849857) 1 NC_007606.1 Code: C; COG: COG0667; reductase 2849857 3796071 SDY_3073 Shigella dysenteriae Sd197 reductase YP_404581.1 2849048 R 300267 CDS YP_404582.1 82778233 3796073 2851021..2851308 1 NC_007606.1 hypothetical protein 2851308 3796073 SDY_3075 Shigella dysenteriae Sd197 hypothetical protein YP_404582.1 2851021 D 300267 CDS YP_404583.1 82778234 3796074 2851497..2852615 1 NC_007606.1 involved in hydrogen uptake; hydrogenase 2 small subunit 2852615 3796074 SDY_3076 Shigella dysenteriae Sd197 hydrogenase 2 small subunit YP_404583.1 2851497 D 300267 CDS YP_404584.1 82778235 3796075 2852618..2853604 1 NC_007606.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 2853604 hybA 3796075 hybA Shigella dysenteriae Sd197 hydrogenase 2 protein HybA YP_404584.1 2852618 D 300267 CDS YP_404585.1 82778236 3796076 2853594..2854772 1 NC_007606.1 ''HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits''; hydrogenase 2 b cytochrome subunit 2854772 hybB 3796076 hybB Shigella dysenteriae Sd197 hydrogenase 2 b cytochrome subunit YP_404585.1 2853594 D 300267 CDS YP_404586.1 82778237 3796077 2854769..2856472 1 NC_007606.1 involved in hydrogen uptake; hydrogenase 2 large subunit 2856472 hybC 3796077 hybC Shigella dysenteriae Sd197 hydrogenase 2 large subunit YP_404586.1 2854769 D 300267 CDS YP_404587.1 82778238 3796078 2856472..2856966 1 NC_007606.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 2856966 hybD 3796078 hybD Shigella dysenteriae Sd197 hydrogenase 2 maturation endopeptidase YP_404587.1 2856472 D 300267 CDS YP_404588.1 82778239 3799729 2856959..2857447 1 NC_007606.1 hydrogenase 2-specific chaperone 2857447 hybE 3799729 hybE Shigella dysenteriae Sd197 hydrogenase 2-specific chaperone YP_404588.1 2856959 D 300267 CDS YP_404589.1 82778240 3799730 2857440..2857781 1 NC_007606.1 may modulate levels of hydrogenase-2; plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 2857781 hybF 3799730 hybF Shigella dysenteriae Sd197 hydrogenase nickel incorporation protein HybF YP_404589.1 2857440 D 300267 CDS YP_404590.1 82778241 3799731 2857794..2858042 1 NC_007606.1 may effect maturation of large subunit of hydrogenase-2; Code: O; COG: COG0298; hydrogenase 2 accessory protein HypG 2858042 hybG 3799731 hybG Shigella dysenteriae Sd197 hydrogenase 2 accessory protein HypG YP_404590.1 2857794 D 300267 CDS YP_404591.1 82778242 3799732 complement(2858165..2859079) 1 NC_007606.1 YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase YghU 2859079 3799732 SDY_3084 Shigella dysenteriae Sd197 glutathione S-transferase YghU YP_404591.1 2858165 R 300267 CDS YP_404592.1 82778243 3799733 2859236..2861095 1 NC_007606.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 2861095 gsp 3799733 gsp Shigella dysenteriae Sd197 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_404592.1 2859236 D 300267 CDS YP_404593.1 82778244 3799734 2861387..2862886 1 NC_007606.1 Code: P; COG: COG0306; low-affinity phosphate transport protein 2862886 pitB 3799734 pitB Shigella dysenteriae Sd197 low-affinity phosphate transport protein YP_404593.1 2861387 D 300267 CDS YP_404594.1 82778245 3799735 complement(2862935..2863639) 1 NC_007606.1 hypothetical protein 2863639 yghT 3799735 yghT Shigella dysenteriae Sd197 hypothetical protein YP_404594.1 2862935 R 300267 CDS YP_404595.1 82778246 3799736 2863681..2863956 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 2863956 insA 3799736 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_404595.1 2863681 D 300267 CDS YP_404596.1 82778247 3799737 complement(2864313..2865290) 1 NC_007606.1 Code: MG; COG: COG0702; hypothetical protein 2865290 3799737 SDY_3089 Shigella dysenteriae Sd197 hypothetical protein YP_404596.1 2864313 R 300267 CDS YP_404597.2 161950050 3799738 complement(2865287..2866975) 1 NC_007606.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 2866975 3799738 SDY_3090 Shigella dysenteriae Sd197 acyl-CoA synthetase YP_404597.2 2865287 R 300267 CDS YP_404598.1 82778249 3799739 complement(2867021..2867416) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2867416 3799739 SDY_3091 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404598.1 2867021 R 300267 CDS YP_009000812.1 578793282 18263126 complement(2867443..2867715) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2867715 18263126 SDY_4737 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000812.1 2867443 R 300267 CDS YP_404599.1 82778250 3799740 2867995..2868825 1 NC_007606.1 ''part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm''; type II secretion protein GspC 2868825 gspC 3799740 gspC Shigella dysenteriae Sd197 type II secretion protein GspC YP_404599.1 2867995 D 300267 CDS YP_404600.1 82778251 3799741 2869065..2870900 1 NC_007606.1 Code: NU; COG: COG1450; type II secretion protein 2870900 gspD 3799741 gspD Shigella dysenteriae Sd197 type II secretion protein YP_404600.1 2869065 D 300267 CDS YP_404601.1 82778252 3799742 2870900..2872393 1 NC_007606.1 Code: NU; COG: COG2804; type II secretion protein 2872393 gspE 3799742 gspE Shigella dysenteriae Sd197 type II secretion protein YP_404601.1 2870900 D 300267 CDS YP_404602.1 82778253 3799743 2872393..2873592 1 NC_007606.1 Code: NU; COG: COG1459; type II secretion protein 2873592 gspF 3799743 gspF Shigella dysenteriae Sd197 type II secretion protein YP_404602.1 2872393 D 300267 CDS YP_404603.1 82778254 3799744 2873633..2874088 1 NC_007606.1 Code: NU; COG: COG2165; type II secretion protein 2874088 gspG 3799744 gspG Shigella dysenteriae Sd197 type II secretion protein YP_404603.1 2873633 D 300267 CDS YP_404604.1 82778255 3799745 2874125..2874655 1 NC_007606.1 type II secretion protein 2874655 gspH 3799745 gspH Shigella dysenteriae Sd197 type II secretion protein YP_404604.1 2874125 D 300267 CDS YP_404605.1 82778256 3799746 2874652..2875023 1 NC_007606.1 Code: NU; COG: COG2165; type II secretion protein 2875023 gspI 3799746 gspI Shigella dysenteriae Sd197 type II secretion protein YP_404605.1 2874652 D 300267 CDS YP_404606.1 82778257 3799747 2875056..2875625 1 NC_007606.1 Code: U; COG: COG4795; type II secretion protein 2875625 gspJ 3799747 gspJ Shigella dysenteriae Sd197 type II secretion protein YP_404606.1 2875056 D 300267 CDS YP_404607.1 82778258 3799035 2875622..2876599 1 NC_007606.1 Code: U; COG: COG3156; type II secretion protein 2876599 gspK 3799035 gspK Shigella dysenteriae Sd197 type II secretion protein YP_404607.1 2875622 D 300267 CDS YP_404608.1 82778259 3799036 2876914..2877774 1 NC_007606.1 similar to general secretory pathway protein L; GspL-like protein 2877774 gspL 3799036 gspL Shigella dysenteriae Sd197 GspL-like protein YP_404608.1 2876914 D 300267 CDS YP_404610.1 82778261 3799039 2879112..2879387 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2879387 insA 3799039 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404610.1 2879112 D 300267 CDS YP_404611.1 82778262 3799040 2879432..2879809 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2879809 insB 3799040 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404611.1 2879432 D 300267 CDS YP_404612.1 82778263 3799042 2880516..2882651 1 NC_007606.1 Code: E; COG: COG1982; ornithine decarboxylase 2882651 speC 3799042 speC Shigella dysenteriae Sd197 ornithine decarboxylase YP_404612.1 2880516 D 300267 CDS YP_404613.1 82778264 3799043 complement(2882701..2884005) 1 NC_007606.1 permease; Code: GEPR; COG: COG0477; nucleosides transporter 2884005 nupG 3799043 nupG Shigella dysenteriae Sd197 nucleosides transporter YP_404613.1 2882701 R 300267 CDS YP_404614.1 82778265 3799044 complement(2884159..2885241) 1 NC_007606.1 ''Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues''; murein transglycosylase C 2885241 mltC 3799044 mltC Shigella dysenteriae Sd197 murein transglycosylase C YP_404614.1 2884159 R 300267 CDS YP_404615.1 82778266 3799045 complement(2885303..2885578) 1 NC_007606.1 Code: CO; COG: COG2924; hypothetical protein 2885578 yggX 3799045 yggX Shigella dysenteriae Sd197 hypothetical protein YP_404615.1 2885303 R 300267 CDS YP_404616.1 82778267 3799046 complement(2885606..2886658) 1 NC_007606.1 G.C --> T.A transversions; Code: L; COG: COG1194; adenine DNA glycosylase 2886658 mutY 3799046 mutY Shigella dysenteriae Sd197 adenine DNA glycosylase YP_404616.1 2885606 R 300267 CDS YP_404617.1 82778268 3799047 2886819..2887538 1 NC_007606.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 2887538 trmB 3799047 trmB Shigella dysenteriae Sd197 tRNA (guanine-N(7)-)-methyltransferase YP_404617.1 2886819 D 300267 CDS YP_404618.2 161950049 3799048 2887538..2887864 1 NC_007606.1 Code: S; COG: COG3171; hypothetical protein 2887864 yggL 3799048 yggL Shigella dysenteriae Sd197 hypothetical protein YP_404618.2 2887538 D 300267 CDS YP_404619.1 82778270 3799049 2888048..2888767 1 NC_007606.1 hypothetical protein 2888767 yggN 3799049 yggN Shigella dysenteriae Sd197 hypothetical protein YP_404619.1 2888048 D 300267 CDS YP_404620.1 82778271 3799050 2888943..2889989 1 NC_007606.1 ''catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis''; L-asparaginase II 2889989 ansB 3799050 ansB Shigella dysenteriae Sd197 L-asparaginase II YP_404620.1 2888943 D 300267 CDS YP_404621.1 82778272 3799051 2890106..2891113 1 NC_007606.1 alpha helix chain 2891113 yggM 3799051 yggM Shigella dysenteriae Sd197 alpha helix chain YP_404621.1 2890106 D 300267 CDS YP_404622.1 82778273 3799052 complement(2891265..2892401) 1 NC_007606.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 2892401 yggW 3799052 yggW Shigella dysenteriae Sd197 coproporphyrinogen III oxidase YP_404622.1 2891265 R 300267 CDS YP_404623.1 82778274 3799053 complement(2892394..2892987) 1 NC_007606.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 2892987 yggV 3799053 yggV Shigella dysenteriae Sd197 deoxyribonucleotide triphosphate pyrophosphatase YP_404623.1 2892394 R 300267 CDS YP_404624.2 161950048 3798997 complement(2892995..2893285) 1 NC_007606.1 Code: S; COG: COG1872; hypothetical protein 2893285 yggU 3798997 yggU Shigella dysenteriae Sd197 hypothetical protein YP_404624.2 2892995 R 300267 CDS YP_404625.1 82778276 3798998 complement(2893282..2893848) 1 NC_007606.1 Code: S; COG: COG0762; resistance protein 2893848 yggT 3798998 yggT Shigella dysenteriae Sd197 resistance protein YP_404625.1 2893282 R 300267 CDS YP_404626.1 82778278 3799000 complement(2893866..2894570) 1 NC_007606.1 Code: R; COG: COG0325; hypothetical protein 2894570 yggS 3799000 yggS Shigella dysenteriae Sd197 hypothetical protein YP_404626.1 2893866 R 300267 CDS YP_404627.1 82778277 3798999 2894543..2895568 1 NC_007606.1 Code: NU; COG: COG2805; pilus retraction ATPase PilT 2895568 yggR 3798999 yggR Shigella dysenteriae Sd197 pilus retraction ATPase PilT YP_404627.1 2894543 D 300267 CDS YP_404628.1 82778279 3799001 complement(2895757..2896173) 1 NC_007606.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 2896173 yqgF 3799001 yqgF Shigella dysenteriae Sd197 Holliday junction resolvase-like protein YP_404628.1 2895757 R 300267 CDS YP_404629.2 161950047 3799002 complement(2896173..2896736) 1 NC_007606.1 Code: K; COG: COG1678; hypothetical protein 2896736 yqgE 3799002 yqgE Shigella dysenteriae Sd197 hypothetical protein YP_404629.2 2896173 R 300267 CDS YP_404630.1 82778281 3799003 complement(2896845..2897795) 1 NC_007606.1 ''The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione''; glutathione synthetase 2897795 gshB 3799003 gshB Shigella dysenteriae Sd197 glutathione synthetase YP_404630.1 2896845 R 300267 CDS YP_404631.2 161950046 3799004 complement(2897808..2898539) 1 NC_007606.1 ''in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase''; 16S ribosomal RNA methyltransferase RsmE 2898539 yggJ 3799004 yggJ Shigella dysenteriae Sd197 16S ribosomal RNA methyltransferase RsmE YP_404631.2 2897808 R 300267 CDS YP_404632.1 82778283 3799005 complement(2898619..2899326) 1 NC_007606.1 Code: L; COG: COG2356; DNA-specific endonuclease I 2899326 endA 3799005 endA Shigella dysenteriae Sd197 DNA-specific endonuclease I YP_404632.1 2898619 R 300267 CDS YP_404633.1 82778284 3799006 complement(2899421..2899918) 1 NC_007606.1 Code: S; COG: COG3091; hypothetical protein 2899918 sprT 3799006 sprT Shigella dysenteriae Sd197 hypothetical protein YP_404633.1 2899421 R 300267 CDS YP_404634.1 82778285 3799007 complement(2899995..2901389) 1 NC_007606.1 Code: GEPR; COG: COG0477; galactose-proton symporter 2901389 galP 3799007 galP Shigella dysenteriae Sd197 galactose-proton symporter YP_404634.1 2899995 R 300267 CDS YP_404635.1 82778286 3799008 complement(2901826..2902980) 1 NC_007606.1 AdoMet synthetase; methyl and propylamine donor, corepressor of met genes; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 2902980 metK 3799008 metK Shigella dysenteriae Sd197 S-adenosylmethionine synthetase YP_404635.1 2901826 R 300267 CDS YP_404636.1 82778287 3799009 2903036..2903287 1 NC_007606.1 hypothetical protein 2903287 yqgD 3799009 yqgD Shigella dysenteriae Sd197 hypothetical protein YP_404636.1 2903036 D 300267 CDS YP_404637.1 82778288 3799010 complement(2903284..2903499) 1 NC_007606.1 hypothetical protein 2903499 yqgC 3799010 yqgC Shigella dysenteriae Sd197 hypothetical protein YP_404637.1 2903284 R 300267 CDS YP_404638.1 82778289 3799011 2903620..2903766 1 NC_007606.1 hypothetical protein 2903766 yqgB 3799011 yqgB Shigella dysenteriae Sd197 hypothetical protein YP_404638.1 2903620 D 300267 CDS YP_404639.1 82778290 3799012 2903775..2905751 1 NC_007606.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 2905751 speA 3799012 speA Shigella dysenteriae Sd197 arginine decarboxylase YP_404639.1 2903775 D 300267 CDS YP_404640.1 82778291 3799013 2905897..2906169 1 NC_007606.1 hypothetical protein 2906169 3799013 SDY_3135 Shigella dysenteriae Sd197 hypothetical protein YP_404640.1 2905897 D 300267 CDS YP_009000813.1 578793283 18263127 2906209..2906481 1 NC_007606.1 insertion element iso-IS1N protein InsA 2906481 18263127 SDY_4738 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000813.1 2906209 D 300267 CDS YP_404642.1 82778293 3799015 2906508..2906903 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2906903 3799015 SDY_3137 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404642.1 2906508 D 300267 CDS YP_404643.1 82778294 3795388 2907035..2907409 1 NC_007606.1 lipoprotein 2907409 3795388 SDY_3138 Shigella dysenteriae Sd197 lipoprotein YP_404643.1 2907035 D 300267 CDS YP_404644.1 82778295 3795389 2907545..2908465 1 NC_007606.1 catalyzes the formation of putrescine from agmatine; agmatinase 2908465 speB 3795389 speB Shigella dysenteriae Sd197 agmatinase YP_404644.1 2907545 D 300267 CDS YP_404645.1 82778296 3795390 complement(2908513..2909271) 1 NC_007606.1 Code: O; COG: COG0501; hypothetical protein 2909271 yggG 3795390 yggG Shigella dysenteriae Sd197 hypothetical protein YP_404645.1 2908513 R 300267 CDS YP_404646.1 82778297 3795391 2909549..2911540 1 NC_007606.1 ''catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase''; transketolase 2911540 tktA 3795391 tktA Shigella dysenteriae Sd197 transketolase YP_404646.1 2909549 D 300267 CDS YP_404647.1 82778298 3795392 complement(2911856..2912251) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2912251 3795392 SDY_3142 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404647.1 2911856 R 300267 CDS YP_009000814.1 578793284 18263128 complement(2912278..2912550) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2912550 18263128 SDY_4739 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000814.1 2912278 R 300267 CDS YP_404648.1 82778299 3795393 2912628..2913071 1 NC_007606.1 ''TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein''; PTS system mannitol transporter subunit IIA 2913071 cmtB 3795393 cmtB Shigella dysenteriae Sd197 PTS system mannitol transporter subunit IIA YP_404648.1 2912628 D 300267 CDS YP_404649.1 82778300 3795394 2913099..2914487 1 NC_007606.1 Code: G; COG: COG2213; cryptic PTS system mannitol-specific transporter subunit IIBC 2914487 cmtA 3795394 cmtA Shigella dysenteriae Sd197 cryptic PTS system mannitol-specific transporter subunit IIBC YP_404649.1 2913099 D 300267 CDS YP_404650.2 578793285 3795395 2914502..2915779 1 NC_007606.1 Code: ER; COG: COG1063; oxidoreductase 2915779 3795395 SDY_3145 Shigella dysenteriae Sd197 oxidoreductase YP_404650.2 2914502 D 300267 CDS YP_404651.1 82778302 3795397 2916763..2917272 1 NC_007606.1 Code: K; COG: COG3722; DNA-binding transcriptional regulator 2917272 yggD 3795397 yggD Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YP_404651.1 2916763 D 300267 CDS YP_404652.1 82778303 3795398 2917269..2917982 1 NC_007606.1 Code: H; COG: COG1072; fructose transport system kinase 2917982 frcK 3795398 frcK Shigella dysenteriae Sd197 fructose transport system kinase YP_404652.1 2917269 D 300267 CDS YP_404653.1 82778304 3795399 complement(2917954..2918631) 1 NC_007606.1 Code: P; COG: COG1118; ABC transporter ATP-binding protein 2918631 3795399 SDY_3149 Shigella dysenteriae Sd197 ABC transporter ATP-binding protein YP_404653.1 2917954 R 300267 CDS YP_404656.1 82778307 3795402 complement(2919290..2919997) 1 NC_007606.1 Code: P; COG: COG0619; hypothetical protein 2919997 3795402 SDY_3152 Shigella dysenteriae Sd197 hypothetical protein YP_404656.1 2919290 R 300267 CDS YP_404657.1 82778308 3795403 complement(2919998..2920576) 1 NC_007606.1 hypothetical protein 2920576 3795403 SDY_3153 Shigella dysenteriae Sd197 hypothetical protein YP_404657.1 2919998 R 300267 CDS YP_404658.1 82778309 3795404 complement(2920599..2921030) 1 NC_007606.1 Code: R; COG: COG1661; hypothetical protein 2921030 3795404 SDY_3154 Shigella dysenteriae Sd197 hypothetical protein YP_404658.1 2920599 R 300267 CDS YP_404659.1 82778310 3795405 2921402..2922421 1 NC_007606.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 2922421 epd 3795405 epd Shigella dysenteriae Sd197 erythrose 4-phosphate dehydrogenase YP_404659.1 2921402 D 300267 CDS YP_404660.1 82778311 3795406 2922471..2923634 1 NC_007606.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 2923634 pgk 3795406 pgk Shigella dysenteriae Sd197 phosphoglycerate kinase YP_404660.1 2922471 D 300267 CDS YP_404661.1 82778312 3795407 2923849..2924928 1 NC_007606.1 ''catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate''; fructose-bisphosphate aldolase 2924928 fba 3795407 fba Shigella dysenteriae Sd197 fructose-bisphosphate aldolase YP_404661.1 2923849 D 300267 CDS YP_404662.1 82778313 3795558 2925119..2925979 1 NC_007606.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive ion channel MscS 2925979 yggB 3795558 yggB Shigella dysenteriae Sd197 mechanosensitive ion channel MscS YP_404662.1 2925119 D 300267 CDS YP_404663.1 82778314 3795559 2926118..2926753 1 NC_007606.1 Involved in the export of arginine; arginine exporter protein 2926753 yggA 3795559 yggA Shigella dysenteriae Sd197 arginine exporter protein YP_404663.1 2926118 D 300267 CDS YP_404664.1 82778315 3795560 2926846..2927586 1 NC_007606.1 Code: S; COG: COG2968; hypothetical protein 2927586 yggE 3795560 yggE Shigella dysenteriae Sd197 hypothetical protein YP_404664.1 2926846 D 300267 CDS YP_009000815.1 578793286 18263129 2927835..2928107 1 NC_007606.1 insertion element iso-IS1N protein InsA 2928107 18263129 SDY_4740 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000815.1 2927835 D 300267 CDS YP_404666.1 82778317 3795562 2928134..2928529 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2928529 3795562 SDY_3162 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404666.1 2928134 D 300267 CDS YP_404668.1 82778319 3795565 complement(2931985..2932878) 1 NC_007606.1 binds to 13-mers at oriC; specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 2932878 iciA 3795565 iciA Shigella dysenteriae Sd197 chromosome replication initiation inhibitor protein YP_404668.1 2931985 R 300267 CDS YP_404669.1 82778320 3795566 complement(2932990..2933385) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2933385 3795566 SDY_3166 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404669.1 2932990 R 300267 CDS YP_009000816.1 578793287 18263130 complement(2933412..2933684) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2933684 18263130 SDY_4741 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000816.1 2933412 R 300267 CDS YP_404671.1 82778322 3795568 2934073..2934732 1 NC_007606.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 2934732 rpiA 3795568 rpiA Shigella dysenteriae Sd197 ribose-5-phosphate isomerase A YP_404671.1 2934073 D 300267 CDS YP_404672.1 82778323 3795569 2934988..2936220 1 NC_007606.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 2936220 serA 3795569 serA Shigella dysenteriae Sd197 D-3-phosphoglycerate dehydrogenase YP_404672.1 2934988 D 300267 CDS YP_404673.1 82778324 3795570 complement(2936601..2937149) 1 NC_007606.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 2937149 ygfA 3795570 ygfA Shigella dysenteriae Sd197 ligase YP_404673.1 2936601 R 300267 CDS YP_404674.1 82778325 3795571 complement(2937449..2937778) 1 NC_007606.1 Code: S; COG: COG3027; Z-ring-associated protein 2937778 ygfE 3795571 ygfE Shigella dysenteriae Sd197 Z-ring-associated protein YP_404674.1 2937449 R 300267 CDS YP_404675.2 161950045 3795572 2937946..2938524 1 NC_007606.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 2938524 ygfB 3795572 ygfB Shigella dysenteriae Sd197 hypothetical protein YP_404675.2 2937946 D 300267 CDS YP_404676.1 82778327 3795573 2938550..2939875 1 NC_007606.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 2939875 pepP 3795573 pepP Shigella dysenteriae Sd197 proline aminopeptidase P II YP_404676.1 2938550 D 300267 CDS YP_404677.1 82778328 3795574 2939872..2941050 1 NC_007606.1 2-octaprenyl-6-methoxyphenol--> 2-octaprenyl-6-methoxy-1, 4-benzoquinone; ''Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone''; 2-octaprenyl-6-methoxyphenyl hydroxylase 2941050 ubiH 3795574 ubiH Shigella dysenteriae Sd197 2-octaprenyl-6-methoxyphenyl hydroxylase YP_404677.1 2939872 D 300267 CDS YP_404678.1 82778329 3795575 2941073..2942275 1 NC_007606.1 Code: HC; COG: COG0654; hypothetical protein 2942275 visC 3795575 visC Shigella dysenteriae Sd197 hypothetical protein YP_404678.1 2941073 D 300267 CDS YP_404679.1 82778330 3795576 2942723..2943817 1 NC_007606.1 T protein; tetrahydrofolate-dependent; ''catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein''; glycine cleavage system aminomethyltransferase T 2943817 gcvT 3795576 gcvT Shigella dysenteriae Sd197 glycine cleavage system aminomethyltransferase T YP_404679.1 2942723 D 300267 CDS YP_404680.1 82778331 3796002 2943841..2944230 1 NC_007606.1 ''part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor''; glycine cleavage system protein H 2944230 gcvH 3796002 gcvH Shigella dysenteriae Sd197 glycine cleavage system protein H YP_404680.1 2943841 D 300267 CDS YP_404681.1 82778332 3796003 2944348..2947221 1 NC_007606.1 P protein of glycine cleavage system; acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2947221 gcvP 3796003 gcvP Shigella dysenteriae Sd197 glycine dehydrogenase YP_404681.1 2944348 D 300267 CDS YP_404682.1 82778333 3796006 2949765..2950076 1 NC_007606.1 Code: S; COG: COG3097; hypothetical protein 2950076 yqfB 3796006 yqfB Shigella dysenteriae Sd197 hypothetical protein YP_404682.1 2949765 D 300267 CDS YP_404683.1 82778334 3796007 complement(2950325..2950720) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2950720 3796007 SDY_3182 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404683.1 2950325 R 300267 CDS YP_009000817.1 578793288 18263131 complement(2950747..2951019) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2951019 18263131 SDY_4742 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000817.1 2950747 R 300267 CDS YP_404684.1 82778335 3796008 2950999..2951673 1 NC_007606.1 Code: R; COG: COG1272; oxidoreductase 2951673 3796008 SDY_3183 Shigella dysenteriae Sd197 oxidoreductase YP_404684.1 2950999 D 300267 CDS YP_404685.1 82778336 3796009 complement(2951750..2952730) 1 NC_007606.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 2952730 ygfZ 3796009 ygfZ Shigella dysenteriae Sd197 global regulator YP_404685.1 2951750 R 300267 CDS YP_404686.1 82778337 3796010 2952973..2953239 1 NC_007606.1 Code: S; COG: COG2938; hypothetical protein 2953239 ygfY 3796010 ygfY Shigella dysenteriae Sd197 hypothetical protein YP_404686.1 2952973 D 300267 CDS YP_404687.1 82778338 3796011 2953220..2953627 1 NC_007606.1 hypothetical protein 2953627 3796011 SDY_3186 Shigella dysenteriae Sd197 hypothetical protein YP_404687.1 2953220 D 300267 CDS YP_404688.1 82778339 3796012 complement(2953667..2954188) 1 NC_007606.1 ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic''; flavodoxin FldB 2954188 fldB 3796012 fldB Shigella dysenteriae Sd197 flavodoxin FldB YP_404688.1 2953667 R 300267 CDS YP_404689.1 82778340 3796013 2954300..2955196 1 NC_007606.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 2955196 xerD 3796013 xerD Shigella dysenteriae Sd197 site-specific tyrosine recombinase XerD YP_404689.1 2954300 D 300267 CDS YP_404690.1 82778341 3796014 2955221..2955931 1 NC_007606.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 2955931 dsbC 3796014 dsbC Shigella dysenteriae Sd197 thiol:disulfide interchange protein DsbC YP_404690.1 2955221 D 300267 CDS YP_404691.1 82778342 3796015 2955937..2957670 1 NC_007606.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 2957670 recJ 3796015 recJ Shigella dysenteriae Sd197 ssDNA exonuclease RecJ YP_404691.1 2955937 D 300267 CDS YP_404692.1 82778343 3796016 2957978..2958859 1 NC_007606.1 Code: J; COG: COG1186; peptide chain release factor 2 2958859 prfB 3796016 prfB Shigella dysenteriae Sd197 peptide chain release factor 2 YP_404692.1 2957978 D 300267 CDS YP_404693.1 82778344 3796017 2958869..2960386 1 NC_007606.1 suppressor of ColE1 mutation in primer RNA; ''class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1''; lysyl-tRNA synthetase 2960386 lysS 3796017 lysS Shigella dysenteriae Sd197 lysyl-tRNA synthetase YP_404693.1 2958869 D 300267 CDS YP_404694.1 82778345 3796018 complement(2960429..2960977) 1 NC_007606.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 2960977 3796018 SDY_3193 Shigella dysenteriae Sd197 isopentenyl-diphosphate delta-isomerase YP_404694.1 2960429 R 300267 CDS YP_404695.1 82778346 3796019 2961191..2961466 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2961466 insA 3796019 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404695.1 2961191 D 300267 CDS YP_404696.1 82778347 3796020 2961724..2962026 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 2962026 3796020 SDY_3195 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_404696.1 2961724 D 300267 CDS YP_404697.1 82778348 3796021 2962167..2962934 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 2962934 3796021 SDY_3196 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_404697.1 2962167 D 300267 CDS YP_009000818.1 578793289 18263132 2963433..2963705 1 NC_007606.1 insertion element iso-IS1N protein InsA 2963705 18263132 SDY_4743 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000818.1 2963433 D 300267 CDS YP_404700.1 82778351 3798449 2963732..2964127 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2964127 3798449 SDY_3199 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404700.1 2963732 D 300267 CDS YP_404701.1 82778352 3798450 complement(2964216..2964989) 1 NC_007606.1 Code: P; COG: COG0428; zinc transporter ZupT 2964989 ygiE 3798450 ygiE Shigella dysenteriae Sd197 zinc transporter ZupT YP_404701.1 2964216 R 300267 CDS YP_404702.1 82778353 3798452 complement(2965958..2967118) 1 NC_007606.1 Code: E; COG: COG0754; synthetase/amidase 2967118 ygiC 3798452 ygiC Shigella dysenteriae Sd197 synthetase/amidase YP_404702.1 2965958 R 300267 CDS YP_404703.2 161950044 3798453 complement(2967124..2967795) 1 NC_007606.1 Code: S; COG: COG5463; hypothetical protein 2967795 ygiB 3798453 ygiB Shigella dysenteriae Sd197 hypothetical protein YP_404703.2 2967124 R 300267 CDS YP_404704.1 82778355 3798454 complement(2967683..2967943) 1 NC_007606.1 hypothetical protein 2967943 ygiA 3798454 ygiA Shigella dysenteriae Sd197 hypothetical protein YP_404704.1 2967683 R 300267 CDS YP_404705.2 161950043 3798455 complement(2967943..2969424) 1 NC_007606.1 specific tolerance to colicin E1; segregation of daughter chromosomes; trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 2969424 tolC 3798455 tolC Shigella dysenteriae Sd197 outer membrane channel protein YP_404705.2 2967943 R 300267 CDS YP_404706.1 82778357 3798456 2969629..2970258 1 NC_007606.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 2970258 nudF 3798456 nudF Shigella dysenteriae Sd197 ADP-ribose pyrophosphatase YP_404706.1 2969629 D 300267 CDS YP_404707.1 82778358 3798457 2970259..2970681 1 NC_007606.1 Code: S; COG: COG3151; hypothetical protein 2970681 yqiB 3798457 yqiB Shigella dysenteriae Sd197 hypothetical protein YP_404707.1 2970259 D 300267 CDS YP_404708.1 82778359 3798458 2970706..2971533 1 NC_007606.1 Code: R; COG: COG1409; cyclic 3',5'-adenosine monophosphate phosphodiesterase 2971533 icc 3798458 icc Shigella dysenteriae Sd197 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_404708.1 2970706 D 300267 CDS YP_404709.1 82778360 3798459 2971533..2972114 1 NC_007606.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 2972114 yqiA 3798459 yqiA Shigella dysenteriae Sd197 esterase YP_404709.1 2971533 D 300267 CDS YP_404710.1 82778361 3798460 2972143..2974035 1 NC_007606.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 2974035 parE 3798460 parE Shigella dysenteriae Sd197 DNA topoisomerase IV subunit B YP_404710.1 2972143 D 300267 CDS YP_404711.1 82778362 3798461 complement(2974083..2974397) 1 NC_007606.1 Code: S; COG: COG1359; hypothetical protein 2974397 ygiN 3798461 ygiN Shigella dysenteriae Sd197 hypothetical protein YP_404711.1 2974083 R 300267 CDS YP_404712.1 82778363 3798462 complement(2974428..2975009) 1 NC_007606.1 Code: R; COG: COG2249; modulator of drug activity B 2975009 mdaB 3798462 mdaB Shigella dysenteriae Sd197 modulator of drug activity B YP_404712.1 2974428 R 300267 CDS YP_404713.1 82778364 3798463 complement(2975119..2976468) 1 NC_007606.1 Code: T; COG: COG0642; sensor protein QseC 2976468 qseC 3798463 qseC Shigella dysenteriae Sd197 sensor protein QseC YP_404713.1 2975119 R 300267 CDS YP_404714.1 82778365 3798464 complement(2976465..2977124) 1 NC_007606.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 2977124 ygiX 3798464 ygiX Shigella dysenteriae Sd197 DNA-binding transcriptional regulator QseB YP_404714.1 2976465 R 300267 CDS YP_404715.1 82778366 3798465 2977276..2977668 1 NC_007606.1 Code: S; COG: COG3111; hypothetical protein 2977668 ygiW 3798465 ygiW Shigella dysenteriae Sd197 hypothetical protein YP_404715.1 2977276 D 300267 CDS YP_404716.1 82778367 3798427 2977721..2978203 1 NC_007606.1 Code: L; COG: COG3449; hypothetical protein 2978203 3798427 SDY_3216 Shigella dysenteriae Sd197 hypothetical protein YP_404716.1 2977721 D 300267 CDS YP_404717.1 82778368 3798428 2978312..2979919 1 NC_007606.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system; binding protein 2979919 3798428 SDY_3217 Shigella dysenteriae Sd197 binding protein YP_404717.1 2978312 D 300267 CDS YP_404718.1 82778369 3798429 2980057..2982315 1 NC_007606.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 2982315 parC 3798429 parC Shigella dysenteriae Sd197 DNA topoisomerase IV subunit A YP_404718.1 2980057 D 300267 CDS YP_404719.1 82778370 3798430 2982549..2983286 1 NC_007606.1 Code: I; COG: COG0204; 1-acyl-sn-glycerol-3-phosphate acyltransferase 2983286 plsC 3798430 plsC Shigella dysenteriae Sd197 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_404719.1 2982549 D 300267 CDS YP_404720.1 82778371 3798431 2983361..2984773 1 NC_007606.1 Code: Q; COG: COG2132; FtsI repressor 2984773 sufI 3798431 sufI Shigella dysenteriae Sd197 FtsI repressor YP_404720.1 2983361 D 300267 CDS YP_404721.1 82778372 3798433 complement(2987147..2987404) 1 NC_007606.1 Code: M; COG: COG4238; outer membrane lipoprotein 2987404 yqhH 3798433 yqhH Shigella dysenteriae Sd197 outer membrane lipoprotein YP_404721.1 2987147 R 300267 CDS YP_404722.1 82778373 3798434 complement(2987453..2988052) 1 NC_007606.1 hypothetical protein 2988052 3798434 SDY_3223 Shigella dysenteriae Sd197 hypothetical protein YP_404722.1 2987453 R 300267 CDS YP_404723.1 82778374 3798435 complement(2988113..2988490) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2988490 insB 3798435 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404723.1 2988113 R 300267 CDS YP_404724.1 82778375 3798436 complement(2988535..2988810) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2988810 insA 3798436 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404724.1 2988535 R 300267 CDS YP_404725.1 82778376 3798437 complement(2989128..2989781) 1 NC_007606.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 2989781 ribB 3798437 ribB Shigella dysenteriae Sd197 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_404725.1 2989128 R 300267 CDS YP_404726.1 82778377 3798438 2990095..2990454 1 NC_007606.1 Code: S; COG: COG2960; hypothetical protein 2990454 3798438 SDY_3227 Shigella dysenteriae Sd197 hypothetical protein YP_404726.1 2990095 D 300267 CDS YP_404727.1 82778378 3798439 complement(2990489..2990689) 1 NC_007606.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 2990689 glgS 3798439 glgS Shigella dysenteriae Sd197 glycogen synthesis protein GlgS YP_404727.1 2990489 R 300267 CDS YP_404728.1 82778379 3798440 complement(2990706..2991101) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 2991101 3798440 SDY_3229 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404728.1 2990706 R 300267 CDS YP_009000819.1 578793290 18263133 complement(2991128..2991400) 1 NC_007606.1 insertion element iso-IS1N protein InsA 2991400 18263133 SDY_4744 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000819.1 2991128 R 300267 CDS YP_404729.1 82778380 3798441 complement(2991621..2991998) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 2991998 insB 3798441 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404729.1 2991621 R 300267 CDS YP_404730.1 82778381 3798442 complement(2992043..2992318) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 2992318 insA 3798442 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404730.1 2992043 R 300267 CDS YP_009000820.1 578793291 18263134 2992529..2992801 1 NC_007606.1 insertion element iso-IS1N protein InsA 2992801 18263134 SDY_4745 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000820.1 2992529 D 300267 CDS YP_404732.1 82778383 3798444 2992828..2993223 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 2993223 3798444 SDY_3233 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404732.1 2992828 D 300267 CDS YP_404733.1 82778384 3798445 2993224..2994642 1 NC_007606.1 Code: S; COG: COG2268; hypothetical protein 2994642 3798445 SDY_3234 Shigella dysenteriae Sd197 hypothetical protein YP_404733.1 2993224 D 300267 CDS YP_404734.1 82778385 3798446 complement(2995436..2996869) 1 NC_007606.1 ''catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose''; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 2996869 3798446 SDY_3235 Shigella dysenteriae Sd197 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_404734.1 2995436 R 300267 CDS YP_404735.1 82778386 3796748 complement(2996917..2999757) 1 NC_007606.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 2999757 glnE 3796748 glnE Shigella dysenteriae Sd197 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_404735.1 2996917 R 300267 CDS YP_404736.1 82778387 3796749 complement(2999780..3001081) 1 NC_007606.1 Code: S; COG: COG3025; hypothetical protein 3001081 ygiF 3796749 ygiF Shigella dysenteriae Sd197 hypothetical protein YP_404736.1 2999780 R 300267 CDS YP_404737.1 82778388 3796750 3001323..3001943 1 NC_007606.1 Code: T; COG: COG3103; signal transduction protein 3001943 ygiM 3796750 ygiM Shigella dysenteriae Sd197 signal transduction protein YP_404737.1 3001323 D 300267 CDS YP_404738.1 82778389 3796751 3002007..3003245 1 NC_007606.1 ''catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases''; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3003245 cca 3796751 cca Shigella dysenteriae Sd197 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_404738.1 3002007 D 300267 CDS YP_404739.1 82778390 3796753 complement(3004319..3004690) 1 NC_007606.1 ''catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin''; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3004690 folB 3796753 folB Shigella dysenteriae Sd197 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_404739.1 3004319 R 300267 CDS YP_404740.1 82778391 3796754 3004792..3005409 1 NC_007606.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3005409 ygiH 3796754 ygiH Shigella dysenteriae Sd197 glycerol-3-phosphate acyltransferase PlsY YP_404740.1 3004792 D 300267 CDS YP_009000821.1 578793292 18263135 3006081..3006353 1 NC_007606.1 insertion element iso-IS1N protein InsA 3006353 18263135 SDY_4746 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000821.1 3006081 D 300267 CDS YP_404741.1 82778392 3796756 3006380..3006775 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3006775 3796756 SDY_3244 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404741.1 3006380 D 300267 CDS YP_404742.1 82778393 3796759 3008327..3009790 1 NC_007606.1 Code: P; COG: COG0471; hypothetical protein 3009790 ygjE 3796759 ygjE Shigella dysenteriae Sd197 hypothetical protein YP_404742.1 3008327 D 300267 CDS YP_404743.1 82778394 3796760 complement(3009833..3010846) 1 NC_007606.1 ''in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity''; DNA-binding/iron metalloprotein/AP endonuclease 3010846 ygjD 3796760 ygjD Shigella dysenteriae Sd197 DNA-binding/iron metalloprotein/AP endonuclease YP_404743.1 3009833 R 300267 CDS YP_404744.1 82778395 3796761 3011084..3011299 1 NC_007606.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3011299 rpsU 3796761 rpsU Shigella dysenteriae Sd197 30S ribosomal protein S21 YP_404744.1 3011084 D 300267 CDS YP_404745.1 82778396 3796762 3011411..3013156 1 NC_007606.1 DNA biosynthesis; synthesizes RNA primers at the replication forks; DNA primase 3013156 dnaG 3796762 dnaG Shigella dysenteriae Sd197 DNA primase YP_404745.1 3011411 D 300267 CDS YP_404746.1 82778397 3796763 3013351..3015192 1 NC_007606.1 regulation of proteins induced at high temperatures; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3015192 rpoD 3796763 rpoD Shigella dysenteriae Sd197 RNA polymerase sigma factor RpoD YP_404746.1 3013351 D 300267 CDS YP_404747.1 82778398 3796764 complement(3015271..3015777) 1 NC_007606.1 Code: L; COG: COG3663; G/U mismatch-specific DNA glycosylase 3015777 ygjF 3796764 ygjF Shigella dysenteriae Sd197 G/U mismatch-specific DNA glycosylase YP_404747.1 3015271 R 300267 CDS YP_404748.1 82778399 3798369 complement(3016031..3016795) 1 NC_007606.1 Code: P; COG: COG2375; hypothetical protein 3016795 yqjH 3798369 yqjH Shigella dysenteriae Sd197 hypothetical protein YP_404748.1 3016031 R 300267 CDS YP_404749.1 82778400 3798370 3017083..3017706 1 NC_007606.1 Code: K; COG: COG1695; hypothetical protein 3017706 yqjI 3798370 yqjI Shigella dysenteriae Sd197 hypothetical protein YP_404749.1 3017083 D 300267 CDS YP_404750.1 82778401 3798371 complement(3017813..3019333) 1 NC_007606.1 Code: NT; COG: COG0840; aerotaxis sensor receptor, flavoprotein 3019333 aer 3798371 aer Shigella dysenteriae Sd197 aerotaxis sensor receptor, flavoprotein YP_404750.1 3017813 R 300267 CDS YP_404751.1 82778402 3798373 complement(3021172..3021504) 1 NC_007606.1 Code: R; COG: COG0073; hypothetical protein 3021504 ygjH 3798373 ygjH Shigella dysenteriae Sd197 hypothetical protein YP_404751.1 3021172 R 300267 CDS YP_404752.1 82778403 3798374 3021723..3022706 1 NC_007606.1 Code: K; COG: COG1609; DNA-binding transcriptional repressor EbgR 3022706 ebgR 3798374 ebgR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor EbgR YP_404752.1 3021723 D 300267 CDS YP_404753.1 82778404 3798376 complement(3025539..3025934) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3025934 3798376 SDY_3261 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404753.1 3025539 R 300267 CDS YP_009000822.1 578793293 18263136 complement(3025961..3026233) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3026233 18263136 SDY_4747 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000822.1 3025961 R 300267 CDS YP_404754.1 82778405 3798378 3027514..3029865 1 NC_007606.1 glycosyl hydrolase 3029865 ygjK 3798378 ygjK Shigella dysenteriae Sd197 glycosyl hydrolase YP_404754.1 3027514 D 300267 CDS YP_404755.1 82778406 3798379 3030250..3031689 1 NC_007606.1 hypothetical protein 3031689 3798379 SDY_3264 Shigella dysenteriae Sd197 hypothetical protein YP_404755.1 3030250 D 300267 CDS YP_404756.1 82778407 3798380 3031993..3034011 1 NC_007606.1 Code: C; COG: COG1902; NADPH dehydrogenase 3034011 ygjL 3798380 ygjL Shigella dysenteriae Sd197 NADPH dehydrogenase YP_404756.1 3031993 D 300267 CDS YP_404757.1 82778408 3798381 complement(3034056..3034472) 1 NC_007606.1 Code: K; COG: COG5499; hypothetical protein 3034472 ygjM 3798381 ygjM Shigella dysenteriae Sd197 hypothetical protein YP_404757.1 3034056 R 300267 CDS YP_404758.1 82778409 3798382 complement(3034742..3035908) 1 NC_007606.1 Code: J; COG: COG2813; SAM-dependent 23S ribosomal RNA mG1835 methyltransferase 3035908 ygjO 3798382 ygjO Shigella dysenteriae Sd197 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase YP_404758.1 3034742 R 300267 CDS YP_404759.1 82778410 3798383 3035927..3036466 1 NC_007606.1 Code: R; COG: COG1451; hypothetical protein 3036466 ygjP 3798383 ygjP Shigella dysenteriae Sd197 hypothetical protein YP_404759.1 3035927 D 300267 CDS YP_009000823.1 578793294 18263137 3036596..3036868 1 NC_007606.1 insertion element iso-IS1N protein InsA 3036868 18263137 SDY_4748 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000823.1 3036596 D 300267 CDS YP_404761.1 82778412 3798385 3036895..3037290 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3037290 3798385 SDY_3270 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404761.1 3036895 D 300267 CDS YP_404762.1 82778413 3798387 3038071..3039075 1 NC_007606.1 Code: R; COG: COG0673; hypothetical protein 3039075 ygjR 3798387 ygjR Shigella dysenteriae Sd197 hypothetical protein YP_404762.1 3038071 D 300267 CDS YP_404763.1 82778414 3798670 3039358..3040323 1 NC_007606.1 Code: P; COG: COG0861; transport protein 3040323 ygjT 3798670 ygjT Shigella dysenteriae Sd197 transport protein YP_404763.1 3039358 D 300267 CDS YP_404764.1 82778415 3798671 3040877..3042121 1 NC_007606.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3042121 ygjU 3798671 ygjU Shigella dysenteriae Sd197 serine/threonine transporter SstT YP_404764.1 3040877 D 300267 CDS YP_404765.1 82778416 3798672 complement(3042126..3042665) 1 NC_007606.1 hypothetical protein 3042665 ygjV 3798672 ygjV Shigella dysenteriae Sd197 hypothetical protein YP_404765.1 3042126 R 300267 CDS YP_404766.1 82778417 3798673 complement(3042759..3044246) 1 NC_007606.1 Code: G; COG: COG2721; altronate hydrolase 3044246 uxaA 3798673 uxaA Shigella dysenteriae Sd197 altronate hydrolase YP_404766.1 3042759 R 300267 CDS YP_404767.1 82778418 3798675 3045854..3047272 1 NC_007606.1 Code: GEPR; COG: COG0477; hexuronates transporter 3047272 exuT 3798675 exuT Shigella dysenteriae Sd197 hexuronates transporter YP_404767.1 3045854 D 300267 CDS YP_404768.1 82778419 3798676 complement(3047297..3047674) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3047674 insB 3798676 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404768.1 3047297 R 300267 CDS YP_404769.1 82778420 3798677 complement(3047719..3047994) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3047994 insA 3798677 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404769.1 3047719 R 300267 CDS YP_404770.2 161950042 3798678 3048179..3048955 1 NC_007606.1 ''regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.''; DNA-binding transcriptional repressor ExuR 3048955 exuR 3798678 exuR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor ExuR YP_404770.2 3048179 D 300267 CDS YP_404771.1 82778422 3798679 3049300..3049962 1 NC_007606.1 Code: S; COG: COG0586; hypothetical protein 3049962 yqjA 3798679 yqjA Shigella dysenteriae Sd197 hypothetical protein YP_404771.1 3049300 D 300267 CDS YP_404772.1 82778423 3798680 3049966..3050349 1 NC_007606.1 hypothetical protein 3050349 yqjB 3798680 yqjB Shigella dysenteriae Sd197 hypothetical protein YP_404772.1 3049966 D 300267 CDS YP_404773.1 82778424 3798681 3050481..3050864 1 NC_007606.1 hypothetical protein 3050864 yqjC 3798681 yqjC Shigella dysenteriae Sd197 hypothetical protein YP_404773.1 3050481 D 300267 CDS YP_404774.1 82778425 3798682 3050902..3051207 1 NC_007606.1 Code: S; COG: COG4575; hypothetical protein 3051207 yqjD 3798682 yqjD Shigella dysenteriae Sd197 hypothetical protein YP_404774.1 3050902 D 300267 CDS YP_404775.1 82778426 3798683 3051210..3051614 1 NC_007606.1 Code: S; COG: COG5393; hypothetical protein 3051614 yqjE 3798683 yqjE Shigella dysenteriae Sd197 hypothetical protein YP_404775.1 3051210 D 300267 CDS YP_404776.1 82778427 3798684 3051604..3051903 1 NC_007606.1 hypothetical protein 3051903 3798684 SDY_3287 Shigella dysenteriae Sd197 hypothetical protein YP_404776.1 3051604 D 300267 CDS YP_404777.2 161950041 3798685 complement(3052028..3052933) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3052933 3798685 SDY_3288 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_404777.2 3052028 R 300267 CDS YP_404778.1 82778429 3798686 complement(3052891..3053256) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 3053256 3798686 SDY_3289 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_404778.1 3052891 R 300267 CDS YP_404779.2 578793295 3798687 3053426..3053818 1 NC_007606.1 Code: S; COG: COG2259; hypothetical protein 3053818 yqjF 3798687 yqjF Shigella dysenteriae Sd197 hypothetical protein YP_404779.2 3053426 D 300267 CDS YP_404780.1 82778431 3798688 3053888..3054874 1 NC_007606.1 Code: O; COG: COG0435; transferase 3054874 yqjG 3798688 yqjG Shigella dysenteriae Sd197 transferase YP_404780.1 3053888 D 300267 CDS YP_404781.1 82778432 3796363 3055157..3055522 1 NC_007606.1 Code: S; COG: COG3152; cytochrome 3055522 yhaH 3796363 yhaH Shigella dysenteriae Sd197 cytochrome YP_404781.1 3055157 D 300267 CDS YP_404782.1 82778433 3796364 complement(3055712..3056107) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3056107 3796364 SDY_3293 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_404782.1 3055712 R 300267 CDS YP_009000824.1 578793296 18263138 complement(3056134..3056406) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3056406 18263138 SDY_4749 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000824.1 3056134 R 300267 CDS YP_404783.1 82778434 3796366 3056700..3056975 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3056975 insA 3796366 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404783.1 3056700 D 300267 CDS YP_404784.1 82778435 3796367 3057020..3057397 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3057397 insB 3796367 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404784.1 3057020 D 300267 CDS YP_404785.1 82778436 3796368 complement(3057722..3058627) 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 3058627 yhaJ 3796368 yhaJ Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_404785.1 3057722 R 300267 CDS YP_404786.1 82778437 3796369 3058732..3059433 1 NC_007606.1 Code: R; COG: COG1741; hypothetical protein 3059433 yhaK 3796369 yhaK Shigella dysenteriae Sd197 hypothetical protein YP_404786.1 3058732 D 300267 CDS YP_404787.1 82778438 3796370 3059453..3059620 1 NC_007606.1 hypothetical protein 3059620 yhaL 3796370 yhaL Shigella dysenteriae Sd197 hypothetical protein YP_404787.1 3059453 D 300267 CDS YP_404788.1 82778439 3796371 complement(3059754..3061064) 1 NC_007606.1 Code: S; COG: COG3681; hypothetical protein 3061064 yhaNM 3796371 yhaNM Shigella dysenteriae Sd197 hypothetical protein YP_404788.1 3059754 R 300267 CDS YP_404789.1 82778440 3796372 complement(3061092..3062423) 1 NC_007606.1 Code: E; COG: COG0814; transport system permease 3062423 yhaO 3796372 yhaO Shigella dysenteriae Sd197 transport system permease YP_404789.1 3061092 R 300267 CDS YP_404790.1 82778441 3796373 complement(3062613..3062990) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3062990 insB 3796373 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404790.1 3062613 R 300267 CDS YP_404791.1 82778442 3796374 complement(3063035..3063310) 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 3063310 insA 3796374 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_404791.1 3063035 R 300267 CDS YP_404792.2 578793297 3796375 complement(3063475..3064839) 1 NC_007606.1 Code: E; COG: COG1760; L-serine dehydratase 3064839 yhaP 3796375 yhaP Shigella dysenteriae Sd197 L-serine dehydratase YP_404792.2 3063475 R 300267 CDS YP_404793.1 82778444 3796377 complement(3065315..3067609) 1 NC_007606.1 Code: C; COG: COG1882; formate acetyltransferase 3 3067609 tdcE 3796377 tdcE Shigella dysenteriae Sd197 formate acetyltransferase 3 YP_404793.1 3065315 R 300267 CDS YP_404794.1 82778445 3796378 complement(3067643..3068863) 1 NC_007606.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3068863 tdcD 3796378 tdcD Shigella dysenteriae Sd197 propionate/acetate kinase YP_404794.1 3067643 R 300267 CDS YP_404795.1 82778446 3796379 complement(3068877..3070208) 1 NC_007606.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3070208 tdcC 3796379 tdcC Shigella dysenteriae Sd197 threonine/serine transporter TdcC YP_404795.1 3068877 R 300267 CDS YP_404796.1 82778447 3796380 complement(3070230..3071219) 1 NC_007606.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3071219 tdcB 3796380 tdcB Shigella dysenteriae Sd197 threonine dehydratase YP_404796.1 3070230 R 300267 CDS YP_404797.1 82778448 3796381 complement(3071318..3072256) 1 NC_007606.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3072256 tdcA 3796381 tdcA Shigella dysenteriae Sd197 DNA-binding transcriptional activator TdcA YP_404797.1 3071318 R 300267 CDS YP_404798.1 82778449 3796382 3072445..3072789 1 NC_007606.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3072789 tdcR 3796382 tdcR Shigella dysenteriae Sd197 DNA-binding transcriptional activator TdcR YP_404798.1 3072445 D 300267 CDS YP_009000825.1 578793298 18263139 3073132..3073404 1 NC_007606.1 insertion element iso-IS1N protein InsA 3073404 18263139 SDY_4750 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000825.1 3073132 D 300267 CDS YP_404801.1 82778452 3798390 complement(3074215..3074592) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3074592 insB 3798390 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404801.1 3074215 R 300267 CDS YP_404802.1 82778453 3798391 complement(3074637..3074912) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3074912 insA 3798391 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404802.1 3074637 R 300267 CDS YP_404803.1 82778454 3798393 complement(3075357..3075752) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3075752 3798393 SDY_3317 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404803.1 3075357 R 300267 CDS YP_009000826.1 578793299 18263140 complement(3075779..3076051) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3076051 18263140 SDY_4752 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000826.1 3075779 R 300267 CDS YP_404804.2 161950040 3798394 complement(3077008..3078153) 1 NC_007606.1 Code: G; COG: COG1929; glycerate kinase 3078153 yhaD 3798394 yhaD Shigella dysenteriae Sd197 glycerate kinase YP_404804.2 3077008 R 300267 CDS YP_404805.2 161950039 3798395 complement(3078250..3079140) 1 NC_007606.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3079140 garR 3798395 garR Shigella dysenteriae Sd197 tartronate semialdehyde reductase YP_404805.2 3078250 R 300267 CDS YP_404806.1 82778457 3798396 complement(3079170..3079940) 1 NC_007606.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3079940 yhaF 3798396 yhaF Shigella dysenteriae Sd197 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_404806.1 3079170 R 300267 CDS YP_404807.1 82778458 3798398 3081323..3081598 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3081598 insA 3798398 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404807.1 3081323 D 300267 CDS YP_404808.1 82778459 3798399 3081643..3082020 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3082020 insB 3798399 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404808.1 3081643 D 300267 CDS YP_404809.1 82778460 3798400 3082053..3083144 1 NC_007606.1 Code: NU; COG: COG3539; fimbrial protein 3083144 yraK 3798400 yraK Shigella dysenteriae Sd197 fimbrial protein YP_404809.1 3082053 D 300267 CDS YP_404810.1 82778461 3798401 complement(3083187..3084047) 1 NC_007606.1 Code: R; COG: COG0313; hypothetical protein 3084047 yraL 3798401 yraL Shigella dysenteriae Sd197 hypothetical protein YP_404810.1 3083187 R 300267 CDS YP_404811.1 82778462 3798402 3084112..3086148 1 NC_007606.1 Code: R; COG: COG3107; glycosylase 3086148 yraM 3798402 yraM Shigella dysenteriae Sd197 glycosylase YP_404811.1 3084112 D 300267 CDS YP_404812.1 82778463 3798403 3086106..3086501 1 NC_007606.1 Code: L; COG: COG0792; hypothetical protein 3086501 yraN 3798403 yraN Shigella dysenteriae Sd197 hypothetical protein YP_404812.1 3086106 D 300267 CDS YP_404813.1 82778464 3798404 3086521..3087111 1 NC_007606.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; chromosome replication initiator DnaA 3087111 yraO 3798404 yraO Shigella dysenteriae Sd197 chromosome replication initiator DnaA YP_404813.1 3086521 D 300267 CDS YP_404814.1 82778465 3798405 3087121..3087696 1 NC_007606.1 Code: R; COG: COG2823; hypothetical protein 3087696 yraP 3798405 yraP Shigella dysenteriae Sd197 hypothetical protein YP_404814.1 3087121 D 300267 CDS YP_404815.1 82778466 3798407 complement(3088923..3089603) 1 NC_007606.1 Code: MG; COG: COG0702; hypothetical protein 3089603 yraR 3798407 yraR Shigella dysenteriae Sd197 hypothetical protein YP_404815.1 3088923 R 300267 CDS YP_404816.1 82778467 3798408 3089644..3090204 1 NC_007606.1 Code: R; COG: COG0693; hypothetical protein 3090204 yhbO 3798408 yhbO Shigella dysenteriae Sd197 hypothetical protein YP_404816.1 3089644 D 300267 CDS YP_404817.1 82778468 3798409 complement(3090184..3090627) 1 NC_007606.1 Code: S; COG: COG3787; hypothetical protein 3090627 yhbP 3798409 yhbP Shigella dysenteriae Sd197 hypothetical protein YP_404817.1 3090184 R 300267 CDS YP_404818.1 82778469 3798410 3090678..3090980 1 NC_007606.1 Code: L; COG: COG2827; GIY-YIG nuclease superfamily protein 3090980 yhbQ 3798410 yhbQ Shigella dysenteriae Sd197 GIY-YIG nuclease superfamily protein YP_404818.1 3090678 D 300267 CDS YP_404819.1 82778470 3798411 complement(3090967..3091470) 1 NC_007606.1 Code: R; COG: COG3153; hypothetical protein 3091470 yhbS 3798411 yhbS Shigella dysenteriae Sd197 hypothetical protein YP_404819.1 3090967 R 300267 CDS YP_404820.1 82778471 3798412 complement(3091464..3091988) 1 NC_007606.1 Code: I; COG: COG3154; hypothetical protein 3091988 yhbT 3798412 yhbT Shigella dysenteriae Sd197 hypothetical protein YP_404820.1 3091464 R 300267 CDS YP_404821.1 82778472 3798413 3092197..3093192 1 NC_007606.1 Code: O; COG: COG0826; collagenase 3093192 yhbU 3798413 yhbU Shigella dysenteriae Sd197 collagenase YP_404821.1 3092197 D 300267 CDS YP_404822.1 82778473 3798414 3093183..3094079 1 NC_007606.1 Code: O; COG: COG0826; hypothetical protein 3094079 yhbV 3798414 yhbV Shigella dysenteriae Sd197 hypothetical protein YP_404822.1 3093183 D 300267 CDS YP_404823.1 82778474 3798415 3094160..3095167 1 NC_007606.1 Code: C; COG: COG2141; hypothetical protein 3095167 yhbW 3798415 yhbW Shigella dysenteriae Sd197 hypothetical protein YP_404823.1 3094160 D 300267 CDS YP_404824.1 82778475 3798416 complement(3095284..3096528) 1 NC_007606.1 tryptophan transporter of high affinity; tryptophan permease 3096528 mtr 3798416 mtr Shigella dysenteriae Sd197 tryptophan permease YP_404824.1 3095284 R 300267 CDS YP_404825.2 161950038 3798417 complement(3096682..3098571) 1 NC_007606.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3098571 deaD 3798417 deaD Shigella dysenteriae Sd197 ATP-dependent RNA helicase DeaD YP_404825.2 3096682 R 300267 CDS YP_404826.1 82778477 3798418 complement(3098751..3099635) 1 NC_007606.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3099635 yhbM 3798418 yhbM Shigella dysenteriae Sd197 lipoprotein NlpI YP_404826.1 3098751 R 300267 CDS YP_404827.1 82778478 3798419 complement(3099744..3101948) 1 NC_007606.1 cytidylate kinase activity; Code: J; COG: COG1185; polynucleotide phosphorylase 3101948 pnp 3798419 pnp Shigella dysenteriae Sd197 polynucleotide phosphorylase YP_404827.1 3099744 R 300267 CDS YP_404828.1 82778479 3798420 complement(3102126..3102395) 1 NC_007606.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3102395 rpsO 3798420 rpsO Shigella dysenteriae Sd197 30S ribosomal protein S15 YP_404828.1 3102126 R 300267 CDS YP_404829.1 82778480 3798421 complement(3102544..3103488) 1 NC_007606.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3103488 truB 3798421 truB Shigella dysenteriae Sd197 tRNA pseudouridine synthase B YP_404829.1 3102544 R 300267 CDS YP_404830.1 82778481 3798422 complement(3103488..3103889) 1 NC_007606.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3103889 rbfA 3798422 rbfA Shigella dysenteriae Sd197 ribosome-binding factor A YP_404830.1 3103488 R 300267 CDS YP_404831.1 82778482 3798423 complement(3104053..3106725) 1 NC_007606.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3106725 infB 3798423 infB Shigella dysenteriae Sd197 translation initiation factor IF-2 YP_404831.1 3104053 R 300267 CDS YP_404832.1 82778483 3798424 complement(3106750..3108237) 1 NC_007606.1 L factor; ''modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination''; transcription elongation factor NusA 3108237 nusA 3798424 nusA Shigella dysenteriae Sd197 transcription elongation factor NusA YP_404832.1 3106750 R 300267 CDS YP_404833.2 161950037 3798425 complement(3108265..3108717) 1 NC_007606.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3108717 yhbC 3798425 yhbC Shigella dysenteriae Sd197 hypothetical protein YP_404833.2 3108265 R 300267 CDS YP_404834.1 82778485 3798766 3109348..3110691 1 NC_007606.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3110691 argG 3798766 argG Shigella dysenteriae Sd197 argininosuccinate synthase YP_404834.1 3109348 D 300267 CDS YP_404835.2 161950036 3798767 complement(3110699..3112306) 1 NC_007606.1 Code: R; COG: COG2194; alkaline phosphatase I 3112306 yhbX 3798767 yhbX Shigella dysenteriae Sd197 alkaline phosphatase I YP_404835.2 3110699 R 300267 CDS YP_009000827.1 578793300 18263141 complement(3112800..3113072) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3113072 18263141 SDY_4754 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000827.1 3112800 R 300267 CDS YP_404838.1 82778489 3798771 complement(3113578..3113910) 1 NC_007606.1 Code: U; COG: COG1314; preprotein translocase subunit SecG 3113910 secG 3798771 secG Shigella dysenteriae Sd197 preprotein translocase subunit SecG YP_404838.1 3113578 R 300267 CDS YP_404839.1 82778490 3798772 complement(3114138..3115475) 1 NC_007606.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3115475 glmM 3798772 glmM Shigella dysenteriae Sd197 phosphoglucosamine mutase YP_404839.1 3114138 R 300267 CDS YP_404840.2 161950035 3798773 complement(3115468..3116316) 1 NC_007606.1 ''catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate''; dihydropteroate synthase 3116316 folP 3798773 folP Shigella dysenteriae Sd197 dihydropteroate synthase YP_404840.2 3115468 R 300267 CDS YP_404841.1 82778492 3798774 complement(3116406..3118340) 1 NC_007606.1 degrades sigma32, integral membrane peptidase, cell division protein; inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3118340 hflB 3798774 hflB Shigella dysenteriae Sd197 ATP-dependent metalloprotease YP_404841.1 3116406 R 300267 CDS YP_404842.1 82778493 3798775 complement(3118440..3119069) 1 NC_007606.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase 3119069 rrmJ 3798775 rrmJ Shigella dysenteriae Sd197 23S rRNA methyltransferase YP_404842.1 3118440 R 300267 CDS YP_404843.1 82778494 3798776 3119195..3119488 1 NC_007606.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3119488 yhbY 3798776 yhbY Shigella dysenteriae Sd197 RNA-binding protein YhbY YP_404843.1 3119195 D 300267 CDS YP_404844.2 161950034 3798777 complement(3119645..3120121) 1 NC_007606.1 cleaves 3' nucleotide of paused mRNA; ''necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus''; transcription elongation factor GreA 3120121 greA 3798777 greA Shigella dysenteriae Sd197 transcription elongation factor GreA YP_404844.2 3119645 R 300267 CDS YP_404845.1 82778496 3798778 3120368..3121801 1 NC_007606.1 penicillin-binding protein 4; ''penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''; D-alanyl-D-alanine carboxypeptidase 3121801 dacB 3798778 dacB Shigella dysenteriae Sd197 D-alanyl-D-alanine carboxypeptidase YP_404845.1 3120368 D 300267 CDS YP_404846.1 82778497 3798779 complement(3121841..3123013) 1 NC_007606.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3123013 obgE 3798779 obgE Shigella dysenteriae Sd197 GTPase ObgE YP_404846.1 3121841 R 300267 CDS YP_404847.1 82778498 3798780 complement(3123029..3123994) 1 NC_007606.1 Code: GER; COG: COG0697; hypothetical protein 3123994 yhbE 3798780 yhbE Shigella dysenteriae Sd197 hypothetical protein YP_404847.1 3123029 R 300267 CDS YP_404848.1 82778499 3798781 complement(3124121..3124378) 1 NC_007606.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3124378 rpmA 3798781 rpmA Shigella dysenteriae Sd197 50S ribosomal protein L27 YP_404848.1 3124121 R 300267 CDS YP_404849.1 82778500 3798782 complement(3124399..3124710) 1 NC_007606.1 Code: J; COG: COG0261; 50S ribosomal protein L21 3124710 rplU 3798782 rplU Shigella dysenteriae Sd197 50S ribosomal protein L21 YP_404849.1 3124399 R 300267 CDS YP_404850.1 82778501 3796558 3124968..3125939 1 NC_007606.1 Code: H; COG: COG0142; octaprenyl diphosphate synthase 3125939 ispB 3796558 ispB Shigella dysenteriae Sd197 octaprenyl diphosphate synthase YP_404850.1 3124968 D 300267 CDS YP_404851.1 82778502 3796559 3126167..3126445 1 NC_007606.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3126445 nlp 3796559 nlp Shigella dysenteriae Sd197 DNA-binding transcriptional regulator Nlp YP_404851.1 3126167 D 300267 CDS YP_404852.1 82778503 3796560 complement(3126493..3127752) 1 NC_007606.1 first step in murein biosynthesis; adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3127752 murA 3796560 murA Shigella dysenteriae Sd197 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_404852.1 3126493 R 300267 CDS YP_404853.1 82778504 3796561 complement(3127807..3128076) 1 NC_007606.1 Code: K; COG: COG5007; hypothetical protein 3128076 yrbA 3796561 yrbA Shigella dysenteriae Sd197 hypothetical protein YP_404853.1 3127807 R 300267 CDS YP_404854.2 578793301 3796562 complement(3128221..3128514) 1 NC_007606.1 Code: R; COG: COG3113; hypothetical protein 3128514 yrbB 3796562 yrbB Shigella dysenteriae Sd197 hypothetical protein YP_404854.2 3128221 R 300267 CDS YP_404855.1 82778506 3796563 complement(3128514..3129149) 1 NC_007606.1 Code: Q; COG: COG2854; hypothetical protein 3129149 yrbC 3796563 yrbC Shigella dysenteriae Sd197 hypothetical protein YP_404855.1 3128514 R 300267 CDS YP_404856.1 82778507 3796564 complement(3129168..3129719) 1 NC_007606.1 Code: Q; COG: COG1463; hypothetical protein 3129719 yrbD 3796564 yrbD Shigella dysenteriae Sd197 hypothetical protein YP_404856.1 3129168 R 300267 CDS YP_404857.1 82778508 3796565 complement(3129724..3130506) 1 NC_007606.1 Code: Q; COG: COG0767; hypothetical protein 3130506 yrbE 3796565 yrbE Shigella dysenteriae Sd197 hypothetical protein YP_404857.1 3129724 R 300267 CDS YP_404858.1 82778509 3796566 complement(3130514..3131323) 1 NC_007606.1 ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein YrbF 3131323 yrbF 3796566 yrbF Shigella dysenteriae Sd197 ABC transporter ATP-binding protein YrbF YP_404858.1 3130514 R 300267 CDS YP_404859.1 82778510 3796567 3131536..3132501 1 NC_007606.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3132501 yrbG 3796567 yrbG Shigella dysenteriae Sd197 calcium/sodium:proton antiporter YP_404859.1 3131536 D 300267 CDS YP_404860.1 82778511 3796568 3132515..3133501 1 NC_007606.1 Code: M; COG: COG0794; D-arabinose 5-phosphate isomerase 3133501 yrbH 3796568 yrbH Shigella dysenteriae Sd197 D-arabinose 5-phosphate isomerase YP_404860.1 3132515 D 300267 CDS YP_404861.1 82778512 3796569 3133522..3134088 1 NC_007606.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3134088 yrbI 3796569 yrbI Shigella dysenteriae Sd197 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_404861.1 3133522 D 300267 CDS YP_404862.1 82778513 3796570 3134085..3134660 1 NC_007606.1 Code: S; COG: COG3117; hypothetical protein 3134660 yrbK 3796570 yrbK Shigella dysenteriae Sd197 hypothetical protein YP_404862.1 3134085 D 300267 CDS YP_404863.1 82778514 3796571 3134629..3135186 1 NC_007606.1 ''LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system''; lipopolysaccharide transport periplasmic protein LptA 3135186 yhbN 3796571 yhbN Shigella dysenteriae Sd197 lipopolysaccharide transport periplasmic protein LptA YP_404863.1 3134629 D 300267 CDS YP_404864.1 82778515 3796572 3135193..3135918 1 NC_007606.1 Code: R; COG: COG1137; ABC transporter ATP-binding protein YhbG 3135918 yhbG 3796572 yhbG Shigella dysenteriae Sd197 ABC transporter ATP-binding protein YhbG YP_404864.1 3135193 D 300267 CDS YP_404865.1 82778516 3796573 3135966..3137399 1 NC_007606.1 nitrogen and fermentation regulation; ''sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen''; RNA polymerase factor sigma-54 3137399 rpoN 3796573 rpoN Shigella dysenteriae Sd197 RNA polymerase factor sigma-54 YP_404865.1 3135966 D 300267 CDS YP_404866.1 82778517 3796574 3137422..3137709 1 NC_007606.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3137709 yhbH 3796574 yhbH Shigella dysenteriae Sd197 sigma(54) modulation protein YP_404866.1 3137422 D 300267 CDS YP_404867.1 82778518 3796575 3137827..3138318 1 NC_007606.1 regulates N metabolism; Code: GT; COG: COG1762; PTS system transporter subunit IIA 3138318 ptsN 3796575 ptsN Shigella dysenteriae Sd197 PTS system transporter subunit IIA YP_404867.1 3137827 D 300267 CDS YP_404868.1 82778519 3796576 3138364..3139218 1 NC_007606.1 Code: R; COG: COG1660; hypothetical protein 3139218 yhbJ 3796576 yhbJ Shigella dysenteriae Sd197 hypothetical protein YP_404868.1 3138364 D 300267 CDS YP_404869.1 82778520 3796577 3139215..3139487 1 NC_007606.1 nitrogen related, exchanges phosphate with Enzyme I, Hpr; Code: G; COG: COG1925; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3139487 ptsO 3796577 ptsO Shigella dysenteriae Sd197 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_404869.1 3139215 D 300267 CDS YP_404870.1 82778521 3796462 3139701..3140333 1 NC_007606.1 hypothetical protein 3140333 yrbL 3796462 yrbL Shigella dysenteriae Sd197 hypothetical protein YP_404870.1 3139701 D 300267 CDS YP_404871.1 82778522 3796463 complement(3140330..3141058) 1 NC_007606.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3141058 mtgA 3796463 mtgA Shigella dysenteriae Sd197 monofunctional biosynthetic peptidoglycan transglycosylase YP_404871.1 3140330 R 300267 CDS YP_404872.1 82778523 3796464 complement(3141055..3141717) 1 NC_007606.1 SCRP-27A; Code: Q; COG: COG3155; isoprenoid biosynthesis protein with amidotransferase-like domain 3141717 yhbL 3796464 yhbL Shigella dysenteriae Sd197 isoprenoid biosynthesis protein with amidotransferase-like domain YP_404872.1 3141055 R 300267 CDS YP_404873.1 82778524 3796465 complement(3141938..3144274) 1 NC_007606.1 histidine protein kinase/phosphatase, sensor for arcA; sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3144274 arcB 3796465 arcB Shigella dysenteriae Sd197 aerobic respiration control sensor protein ArcB YP_404873.1 3141938 R 300267 CDS YP_404874.1 82778525 3796466 complement(3144370..3145299) 1 NC_007606.1 Code: R; COG: COG1242; hypothetical protein 3145299 yhcC 3796466 yhcC Shigella dysenteriae Sd197 hypothetical protein YP_404874.1 3144370 R 300267 CDS YP_404875.1 82778526 3796467 3145973..3150433 1 NC_007606.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3150433 gltB 3796467 gltB Shigella dysenteriae Sd197 glutamate synthase subunit alpha YP_404875.1 3145973 D 300267 CDS YP_404876.1 82778527 3796468 3150446..3151864 1 NC_007606.1 ''glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate''; glutamate synthase subunit beta 3151864 gltD 3796468 gltD Shigella dysenteriae Sd197 glutamate synthase subunit beta YP_404876.1 3150446 D 300267 CDS YP_404877.1 82778528 3796469 3152048..3153175 1 NC_007606.1 Code: S; COG: COG4804; hypothetical protein 3153175 yhcG 3796469 yhcG Shigella dysenteriae Sd197 hypothetical protein YP_404877.1 3152048 D 300267 CDS YP_404878.1 82778529 3796470 complement(3153235..3153699) 1 NC_007606.1 Code: G; COG: COG2731; hypothetical protein 3153699 yhcH 3796470 yhcH Shigella dysenteriae Sd197 hypothetical protein YP_404878.1 3153235 R 300267 CDS YP_404879.2 161950033 3796471 complement(3153696..3154571) 1 NC_007606.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3154571 yhcI 3796471 yhcI Shigella dysenteriae Sd197 N-acetylmannosamine kinase YP_404879.2 3153696 R 300267 CDS YP_404880.1 82778531 3796472 complement(3154568..3155257) 1 NC_007606.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3155257 yhcJ 3796472 yhcJ Shigella dysenteriae Sd197 N-acetylmannosamine-6-phosphate 2-epimerase YP_404880.1 3154568 R 300267 CDS YP_404881.2 161950032 3796473 complement(3155305..3156795) 1 NC_007606.1 Code: GEPR; COG: COG0477; sialic acid transporter 3156795 nanT 3796473 nanT Shigella dysenteriae Sd197 sialic acid transporter YP_404881.2 3155305 R 300267 CDS YP_404882.1 82778533 3796474 complement(3156904..3157797) 1 NC_007606.1 aldolase; catabolism of sialic acid; not K12?; catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3157797 nanA 3796474 nanA Shigella dysenteriae Sd197 N-acetylneuraminate lyase YP_404882.1 3156904 R 300267 CDS YP_404883.1 82778534 3796475 complement(3157991..3158782) 1 NC_007606.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3158782 yhcK 3796475 yhcK Shigella dysenteriae Sd197 transcriptional regulator NanR YP_404883.1 3157991 R 300267 CDS YP_404885.1 82778536 3796478 complement(3160299..3160796) 1 NC_007606.1 Code: R; COG: COG2969; ClpXP protease specificity-enhancing factor 3160796 sspB 3796478 sspB Shigella dysenteriae Sd197 ClpXP protease specificity-enhancing factor YP_404885.1 3160299 R 300267 CDS YP_404886.1 82778537 3796479 complement(3160802..3161440) 1 NC_007606.1 regulator of transcription; transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3161440 sspA 3796479 sspA Shigella dysenteriae Sd197 stringent starvation protein A YP_404886.1 3160802 R 300267 CDS YP_404887.1 82778538 3796480 complement(3161834..3162226) 1 NC_007606.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3162226 rpsI 3796480 rpsI Shigella dysenteriae Sd197 30S ribosomal protein S9 YP_404887.1 3161834 R 300267 CDS YP_404888.1 82778539 3797572 complement(3162242..3162670) 1 NC_007606.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3162670 rplM 3797572 rplM Shigella dysenteriae Sd197 50S ribosomal protein L13 YP_404888.1 3162242 R 300267 CDS YP_404889.1 82778540 3797573 complement(3162889..3164016) 1 NC_007606.1 Code: R; COG: COG1485; hypothetical protein 3164016 yhcM 3797573 yhcM Shigella dysenteriae Sd197 hypothetical protein YP_404889.1 3162889 R 300267 CDS YP_404890.1 82778541 3797574 3164204..3164608 1 NC_007606.1 Code: S; COG: COG3105; cytochrome d ubiquinol oxidase subunit III 3164608 yhcB 3797574 yhcB Shigella dysenteriae Sd197 cytochrome d ubiquinol oxidase subunit III YP_404890.1 3164204 D 300267 CDS YP_404891.1 82778542 3797575 3164762..3166129 1 NC_007606.1 Code: O; COG: COG0265; serine endoprotease 3166129 degQ 3797575 degQ Shigella dysenteriae Sd197 serine endoprotease YP_404891.1 3164762 D 300267 CDS YP_404892.1 82778543 3797576 3166219..3167286 1 NC_007606.1 Code: O; COG: COG0265; serine endoprotease 3167286 degS 3797576 degS Shigella dysenteriae Sd197 serine endoprotease YP_404892.1 3166219 D 300267 CDS YP_404893.1 82778544 3797577 complement(3167349..3168287) 1 NC_007606.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3168287 mdh 3797577 mdh Shigella dysenteriae Sd197 malate dehydrogenase YP_404893.1 3167349 R 300267 CDS YP_404894.1 82778545 3797578 3168722..3169192 1 NC_007606.1 cer-mediated site-specific recombination; regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3169192 argR 3797578 argR Shigella dysenteriae Sd197 arginine repressor ArgR YP_404894.1 3168722 D 300267 CDS YP_404895.1 82778546 3797579 3169557..3169820 1 NC_007606.1 hypothetical protein 3169820 yhcN 3797579 yhcN Shigella dysenteriae Sd197 hypothetical protein YP_404895.1 3169557 D 300267 CDS YP_404896.1 82778547 3797580 complement(3169876..3170148) 1 NC_007606.1 Code: K; COG: COG2732; hypothetical protein 3170148 yhcO 3797580 yhcO Shigella dysenteriae Sd197 hypothetical protein YP_404896.1 3169876 R 300267 CDS YP_404897.1 82778548 3797581 complement(3170240..3172207) 1 NC_007606.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3172207 yhcP 3797581 yhcP Shigella dysenteriae Sd197 p-hydroxybenzoic acid efflux subunit AaeB YP_404897.1 3170240 R 300267 CDS YP_404898.1 82778549 3797582 complement(3172213..3173145) 1 NC_007606.1 ''with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate''; p-hydroxybenzoic acid efflux subunit AaeA 3173145 yhcQ 3797582 yhcQ Shigella dysenteriae Sd197 p-hydroxybenzoic acid efflux subunit AaeA YP_404898.1 3172213 R 300267 CDS YP_404899.2 161950031 3797583 complement(3173153..3173356) 1 NC_007606.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3173356 yhcR 3797583 yhcR Shigella dysenteriae Sd197 hypothetical protein YP_404899.2 3173153 R 300267 CDS YP_404900.1 82778551 3797584 3173539..3174468 1 NC_007606.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 3174468 qseA 3797584 qseA Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YP_404900.1 3173539 D 300267 CDS YP_404901.1 82778552 3797585 complement(3174596..3176041) 1 NC_007606.1 ''responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA''; protease TldD 3176041 tldD 3797585 tldD Shigella dysenteriae Sd197 protease TldD YP_404901.1 3174596 R 300267 CDS YP_404902.1 82778553 3797586 complement(3176197..3179997) 1 NC_007606.1 Code: S; COG: COG3164; hypothetical protein 3179997 yhdRP 3797586 yhdRP Shigella dysenteriae Sd197 hypothetical protein YP_404902.1 3176197 R 300267 CDS YP_404903.2 161950030 3797587 complement(3180065..3181534) 1 NC_007606.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3181534 cafA 3797587 cafA Shigella dysenteriae Sd197 ribonuclease G YP_404903.2 3180065 R 300267 CDS YP_404904.1 82778555 3797588 complement(3181524..3182117) 1 NC_007606.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3182117 yhdE 3797588 yhdE Shigella dysenteriae Sd197 Maf-like protein YP_404904.1 3181524 R 300267 CDS YP_404905.1 82778556 3797589 complement(3182126..3182614) 1 NC_007606.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3182614 mreD 3797589 mreD Shigella dysenteriae Sd197 rod shape-determining protein MreD YP_404905.1 3182126 R 300267 CDS YP_404906.1 82778557 3797590 complement(3182614..3183717) 1 NC_007606.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3183717 mreC 3797590 mreC Shigella dysenteriae Sd197 rod shape-determining protein MreC YP_404906.1 3182614 R 300267 CDS YP_404907.2 228861760 3797591 complement(3183783..3184826) 1 NC_007606.1 regulator of ftsI; septation function; functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3184826 mreB 3797591 mreB Shigella dysenteriae Sd197 rod shape-determining protein MreB YP_404907.2 3183783 R 300267 CDS YP_404908.1 82778559 3797729 complement(3185131..3187071) 1 NC_007606.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3187071 yhdA 3797729 yhdA Shigella dysenteriae Sd197 regulatory protein CsrD YP_404908.1 3185131 R 300267 CDS YP_404909.1 82778560 3797730 3187223..3188197 1 NC_007606.1 Code: CR; COG: COG0604; dehydrogenase 3188197 yhdH 3797730 yhdH Shigella dysenteriae Sd197 dehydrogenase YP_404909.1 3187223 D 300267 CDS YP_404911.1 82778561 3797731 3188339..3189064 1 NC_007606.1 hypothetical protein 3189064 3797731 SDY_3429 Shigella dysenteriae Sd197 hypothetical protein YP_404911.1 3188339 D 300267 CDS YP_404913.1 82778564 3797734 3189930..3190400 1 NC_007606.1 carrier of biotin; ''composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism''; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3190400 accB 3797734 accB Shigella dysenteriae Sd197 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_404913.1 3189930 D 300267 CDS YP_404914.1 82778565 3797735 3190411..3191760 1 NC_007606.1 ''an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism''; acetyl-CoA carboxylase biotin carboxylase subunit 3191760 accC 3797735 accC Shigella dysenteriae Sd197 acetyl-CoA carboxylase biotin carboxylase subunit YP_404914.1 3190411 D 300267 CDS YP_404915.1 82778566 3797736 3191869..3192111 1 NC_007606.1 Code: S; COG: COG3924; hypothetical protein 3192111 yhdT 3797736 yhdT Shigella dysenteriae Sd197 hypothetical protein YP_404915.1 3191869 D 300267 CDS YP_404916.2 161950029 3797737 3192101..3193552 1 NC_007606.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3193552 panF 3797737 panF Shigella dysenteriae Sd197 sodium/panthothenate symporter YP_404916.2 3192101 D 300267 CDS YP_404917.1 82778568 3797738 3193564..3194445 1 NC_007606.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3194445 prmA 3797738 prmA Shigella dysenteriae Sd197 50S ribosomal protein L11 methyltransferase YP_404917.1 3193564 D 300267 CDS YP_404918.1 82778569 3797739 3194774..3195739 1 NC_007606.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase B 3195739 yhdG 3797739 yhdG Shigella dysenteriae Sd197 tRNA-dihydrouridine synthase B YP_404918.1 3194774 D 300267 CDS YP_404919.1 82778570 3797740 3195765..3196061 1 NC_007606.1 DNA-binding protein; a trans activator for transcription; Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; Fis family transcriptional regulator 3196061 fis 3797740 fis Shigella dysenteriae Sd197 Fis family transcriptional regulator YP_404919.1 3195765 D 300267 CDS YP_404920.1 82778571 3797742 3196778..3197053 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 3197053 insA 3797742 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_404920.1 3196778 D 300267 CDS YP_404921.1 82778572 3797743 3197098..3197475 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3197475 insB 3797743 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_404921.1 3197098 D 300267 CDS YP_404923.1 82778574 3797746 complement(3201152..3201427) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3201427 insA 3797746 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_404923.1 3201152 R 300267 CDS YP_404924.1 82778575 3797747 3201757..3202674 1 NC_007606.1 Code: ET; COG: COG0834; periplasmic binding transport protein 3202674 yhdW 3797747 yhdW Shigella dysenteriae Sd197 periplasmic binding transport protein YP_404924.1 3201757 D 300267 CDS YP_404925.1 82778576 3798658 3203930..3205036 1 NC_007606.1 Code: E; COG: COG0765; transport system permease 3205036 yhdY 3798658 yhdY Shigella dysenteriae Sd197 transport system permease YP_404925.1 3203930 D 300267 CDS YP_404926.2 578793302 3798667 3211672..3212226 1 NC_007606.1 Code: R; COG: COG0663; transferase 3212226 yrdA 3798667 yrdA Shigella dysenteriae Sd197 transferase YP_404926.2 3211672 D 300267 CDS YP_404927.1 82778578 3798668 complement(3212202..3212459) 1 NC_007606.1 hypothetical protein 3212459 yrdB 3798668 yrdB Shigella dysenteriae Sd197 hypothetical protein YP_404927.1 3212202 R 300267 CDS YP_404928.1 82778579 3798669 complement(3212456..3213274) 1 NC_007606.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3213274 aroE 3798669 aroE Shigella dysenteriae Sd197 shikimate 5-dehydrogenase YP_404928.1 3212456 R 300267 CDS YP_404929.1 82778580 3798709 complement(3213279..3213851) 1 NC_007606.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 3213851 yrdC 3798709 yrdC Shigella dysenteriae Sd197 ribosome maturation factor YP_404929.1 3213279 R 300267 CDS YP_404930.1 82778581 3798710 complement(3213856..3214398) 1 NC_007606.1 Code: L; COG: COG0551; DNA topoisomerase 3214398 yrdD 3798710 yrdD Shigella dysenteriae Sd197 DNA topoisomerase YP_404930.1 3213856 R 300267 CDS YP_404931.1 82778582 3798711 complement(3214427..3214900) 1 NC_007606.1 Code: S; COG: COG2922; hypothetical protein 3214900 smg 3798711 smg Shigella dysenteriae Sd197 hypothetical protein YP_404931.1 3214427 R 300267 CDS YP_404932.1 82778583 3798712 complement(3214872..3215996) 1 NC_007606.1 involved in DNA uptake; Code: LU; COG: COG0758; DNA protecting protein DprA 3215996 smf 3798712 smf Shigella dysenteriae Sd197 DNA protecting protein DprA YP_404932.1 3214872 R 300267 CDS YP_404933.1 82778584 3798713 3216126..3216635 1 NC_007606.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3216635 def 3798713 def Shigella dysenteriae Sd197 peptide deformylase YP_404933.1 3216126 D 300267 CDS YP_404934.1 82778585 3798714 3216650..3217597 1 NC_007606.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3217597 fmt 3798714 fmt Shigella dysenteriae Sd197 methionyl-tRNA formyltransferase YP_404934.1 3216650 D 300267 CDS YP_404935.1 82778586 3798715 3217643..3218932 1 NC_007606.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3218932 sun 3798715 sun Shigella dysenteriae Sd197 16S rRNA methyltransferase GidB YP_404935.1 3217643 D 300267 CDS YP_404936.1 82778587 3798716 3218954..3220330 1 NC_007606.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 3220330 trkA 3798716 trkA Shigella dysenteriae Sd197 potassium transporter peripheral membrane protein YP_404936.1 3218954 D 300267 CDS YP_404937.1 82778588 3798718 complement(3221143..3221568) 1 NC_007606.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3221568 zntR 3798718 zntR Shigella dysenteriae Sd197 zinc-responsive transcriptional regulator YP_404937.1 3221143 R 300267 CDS YP_404938.1 82778589 3798719 complement(3221579..3221947) 1 NC_007606.1 hypothetical protein 3221947 yhdN 3798719 yhdN Shigella dysenteriae Sd197 hypothetical protein YP_404938.1 3221579 R 300267 CDS YP_404939.1 82778590 3798720 complement(3222054..3222437) 1 NC_007606.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3222437 rplQ 3798720 rplQ Shigella dysenteriae Sd197 50S ribosomal protein L17 YP_404939.1 3222054 R 300267 CDS YP_404940.1 82778591 3798721 complement(3222478..3223467) 1 NC_007606.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3223467 rpoA 3798721 rpoA Shigella dysenteriae Sd197 DNA-directed RNA polymerase subunit alpha YP_404940.1 3222478 R 300267 CDS YP_404941.1 82778592 3798722 complement(3223493..3224113) 1 NC_007606.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3224113 rpsD 3798722 rpsD Shigella dysenteriae Sd197 30S ribosomal protein S4 YP_404941.1 3223493 R 300267 CDS YP_404942.1 82778593 3798723 complement(3224147..3224536) 1 NC_007606.1 ''located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3''; 30S ribosomal protein S11 3224536 rpsK 3798723 rpsK Shigella dysenteriae Sd197 30S ribosomal protein S11 YP_404942.1 3224147 R 300267 CDS YP_404943.1 82778594 3798724 complement(3224553..3224909) 1 NC_007606.1 ''located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA''; 30S ribosomal protein S13 3224909 rpsM 3798724 rpsM Shigella dysenteriae Sd197 30S ribosomal protein S13 YP_404943.1 3224553 R 300267 CDS YP_404944.1 82778595 3798725 complement(3225056..3225172) 1 NC_007606.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3225172 rpmJ 3798725 rpmJ Shigella dysenteriae Sd197 50S ribosomal protein L36 YP_404944.1 3225056 R 300267 CDS YP_404945.1 82778596 3798726 complement(3225204..3226535) 1 NC_007606.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3226535 secY 3798726 secY Shigella dysenteriae Sd197 preprotein translocase subunit SecY YP_404945.1 3225204 R 300267 CDS YP_404946.1 82778597 3798727 complement(3226543..3226977) 1 NC_007606.1 late assembly protein; 50S ribosomal protein L15 3226977 rplO 3798727 rplO Shigella dysenteriae Sd197 50S ribosomal protein L15 YP_404946.1 3226543 R 300267 CDS YP_404947.1 82778598 3796670 complement(3226981..3227160) 1 NC_007606.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3227160 rpmD 3796670 rpmD Shigella dysenteriae Sd197 50S ribosomal protein L30 YP_404947.1 3226981 R 300267 CDS YP_404948.1 82778599 3796671 complement(3227164..3227667) 1 NC_007606.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3227667 rpsE 3796671 rpsE Shigella dysenteriae Sd197 30S ribosomal protein S5 YP_404948.1 3227164 R 300267 CDS YP_404949.1 82778600 3796672 complement(3227682..3228035) 1 NC_007606.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3228035 rplR 3796672 rplR Shigella dysenteriae Sd197 50S ribosomal protein L18 YP_404949.1 3227682 R 300267 CDS YP_404950.1 82778601 3796673 complement(3228045..3228578) 1 NC_007606.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3228578 rplF 3796673 rplF Shigella dysenteriae Sd197 50S ribosomal protein L6 YP_404950.1 3228045 R 300267 CDS YP_404951.1 82778602 3796674 complement(3228591..3228983) 1 NC_007606.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3228983 rpsH 3796674 rpsH Shigella dysenteriae Sd197 30S ribosomal protein S8 YP_404951.1 3228591 R 300267 CDS YP_404952.1 82778603 3796675 complement(3229017..3229322) 1 NC_007606.1 ''located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif''; 30S ribosomal protein S14 3229322 rpsN 3796675 rpsN Shigella dysenteriae Sd197 30S ribosomal protein S14 YP_404952.1 3229017 R 300267 CDS YP_404953.1 82778604 3796676 complement(3229337..3229876) 1 NC_007606.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3229876 rplE 3796676 rplE Shigella dysenteriae Sd197 50S ribosomal protein L5 YP_404953.1 3229337 R 300267 CDS YP_404954.1 82778605 3796677 complement(3229891..3230205) 1 NC_007606.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3230205 rplX 3796677 rplX Shigella dysenteriae Sd197 50S ribosomal protein L24 YP_404954.1 3229891 R 300267 CDS YP_404955.1 82778606 3796678 complement(3230216..3230587) 1 NC_007606.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3230587 rplN 3796678 rplN Shigella dysenteriae Sd197 50S ribosomal protein L14 YP_404955.1 3230216 R 300267 CDS YP_404956.1 82778607 3796679 complement(3230752..3231006) 1 NC_007606.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3231006 rpsQ 3796679 rpsQ Shigella dysenteriae Sd197 30S ribosomal protein S17 YP_404956.1 3230752 R 300267 CDS YP_404957.1 82778608 3796680 complement(3231006..3231197) 1 NC_007606.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3231197 rpmC 3796680 rpmC Shigella dysenteriae Sd197 50S ribosomal protein L29 YP_404957.1 3231006 R 300267 CDS YP_404958.1 82778609 3796681 complement(3231197..3231607) 1 NC_007606.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3231607 rplP 3796681 rplP Shigella dysenteriae Sd197 50S ribosomal protein L16 YP_404958.1 3231197 R 300267 CDS YP_404959.1 82778610 3796682 complement(3231620..3232321) 1 NC_007606.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3232321 rpsC 3796682 rpsC Shigella dysenteriae Sd197 30S ribosomal protein S3 YP_404959.1 3231620 R 300267 CDS YP_404960.1 82778611 3796683 complement(3232339..3232671) 1 NC_007606.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3232671 rplV 3796683 rplV Shigella dysenteriae Sd197 50S ribosomal protein L22 YP_404960.1 3232339 R 300267 CDS YP_404961.1 82778612 3796684 complement(3232686..3232964) 1 NC_007606.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3232964 rpsS 3796684 rpsS Shigella dysenteriae Sd197 30S ribosomal protein S19 YP_404961.1 3232686 R 300267 CDS YP_404962.1 82778613 3796685 complement(3232981..3233802) 1 NC_007606.1 ''one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation''; 50S ribosomal protein L2 3233802 rplB 3796685 rplB Shigella dysenteriae Sd197 50S ribosomal protein L2 YP_404962.1 3232981 R 300267 CDS YP_404963.1 82778614 3796686 complement(3233820..3234122) 1 NC_007606.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3234122 rplW 3796686 rplW Shigella dysenteriae Sd197 50S ribosomal protein L23 YP_404963.1 3233820 R 300267 CDS YP_404964.1 82778615 3796687 complement(3234119..3234724) 1 NC_007606.1 regulates expression of S10 operon; L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3234724 rplD 3796687 rplD Shigella dysenteriae Sd197 50S ribosomal protein L4 YP_404964.1 3234119 R 300267 CDS YP_404965.1 82778616 3796688 complement(3234735..3235364) 1 NC_007606.1 ''binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin''; 50S ribosomal protein L3 3235364 rplC 3796688 rplC Shigella dysenteriae Sd197 50S ribosomal protein L3 YP_404965.1 3234735 R 300267 CDS YP_404966.1 82778617 3796689 complement(3235397..3235708) 1 NC_007606.1 ''NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex''; 30S ribosomal protein S10 3235708 rpsJ 3796689 rpsJ Shigella dysenteriae Sd197 30S ribosomal protein S10 YP_404966.1 3235397 R 300267 CDS YP_404967.1 82778618 3797787 complement(3236551..3237027) 1 NC_007606.1 an iron storage homoprotein; iron storage protein; bacterioferritin 3237027 bfr 3797787 bfr Shigella dysenteriae Sd197 bacterioferritin YP_404967.1 3236551 R 300267 CDS YP_404968.1 82778619 3797788 complement(3237100..3237294) 1 NC_007606.1 Code: P; COG: COG2906; bacterioferritin-associated ferredoxin 3237294 3797788 SDY_3499 Shigella dysenteriae Sd197 bacterioferritin-associated ferredoxin YP_404968.1 3237100 R 300267 CDS YP_404969.1 82778620 3797789 complement(3237477..3238661) 1 NC_007606.1 duplicate of tufB; ''EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu''; elongation factor Tu 3238661 tufA 3797789 tufA Shigella dysenteriae Sd197 elongation factor Tu YP_404969.1 3237477 R 300267 CDS YP_404970.1 82778621 3797790 complement(3238732..3240846) 1 NC_007606.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3240846 fusA 3797790 fusA Shigella dysenteriae Sd197 elongation factor G YP_404970.1 3238732 R 300267 CDS YP_404971.1 82778622 3797791 complement(3240943..3241413) 1 NC_007606.1 initiates assembly; binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3241413 rpsG 3797791 rpsG Shigella dysenteriae Sd197 30S ribosomal protein S7 YP_404971.1 3240943 R 300267 CDS YP_404972.1 82778623 3797792 complement(3241510..3241884) 1 NC_007606.1 ''interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance''; 30S ribosomal protein S12 3241884 rpsL 3797792 rpsL Shigella dysenteriae Sd197 30S ribosomal protein S12 YP_404972.1 3241510 R 300267 CDS YP_404973.1 82778624 3797793 complement(3242010..3242297) 1 NC_007606.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3242297 yheL 3797793 yheL Shigella dysenteriae Sd197 sulfur transfer complex subunit TusB YP_404973.1 3242010 R 300267 CDS YP_404974.1 82778625 3797794 complement(3242305..3242664) 1 NC_007606.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3242664 yheM 3797794 yheM Shigella dysenteriae Sd197 sulfur relay protein TusC YP_404974.1 3242305 R 300267 CDS YP_404975.1 82778626 3797795 complement(3242664..3243050) 1 NC_007606.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3243050 yheN 3797795 yheN Shigella dysenteriae Sd197 sulfur transfer complex subunit TusD YP_404975.1 3242664 R 300267 CDS YP_404976.1 82778627 3797796 complement(3243050..3243784) 1 NC_007606.1 Code: S; COG: COG2964; hypothetical protein 3243784 yheO 3797796 yheO Shigella dysenteriae Sd197 hypothetical protein YP_404976.1 3243050 R 300267 CDS YP_404977.1 82778628 3797797 complement(3243939..3244733) 1 NC_007606.1 rotamase; FKBP-type peptidylprolyl isomerase 3244733 fkpA 3797797 fkpA Shigella dysenteriae Sd197 FKBP-type peptidylprolyl isomerase YP_404977.1 3243939 R 300267 CDS YP_404978.1 82778629 3797798 3244954..3245172 1 NC_007606.1 Code: S; COG: COG2900; hypothetical protein 3245172 slyX 3797798 slyX Shigella dysenteriae Sd197 hypothetical protein YP_404978.1 3244954 D 300267 CDS YP_404979.1 82778630 3797799 complement(3245221..3245799) 1 NC_007606.1 rotamase; FKBP-type peptidylprolyl isomerase 3245799 slyD 3797799 slyD Shigella dysenteriae Sd197 FKBP-type peptidylprolyl isomerase YP_404979.1 3245221 R 300267 CDS YP_404980.1 82778631 3797800 complement(3245894..3246094) 1 NC_007606.1 Code: R; COG: COG3529; hypothetical protein 3246094 3797800 SDY_3511 Shigella dysenteriae Sd197 hypothetical protein YP_404980.1 3245894 R 300267 CDS YP_404981.1 82778632 3797801 complement(3246104..3247648) 1 NC_007606.1 K+ efflux; Code: P; COG: COG1226; NEM-activable K+/H+ antiporter 3247648 kefB 3797801 kefB Shigella dysenteriae Sd197 NEM-activable K+/H+ antiporter YP_404981.1 3246104 R 300267 CDS YP_404982.1 82778633 3797802 complement(3247648..3248202) 1 NC_007606.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3248202 yheR 3797802 yheR Shigella dysenteriae Sd197 glutathione-regulated potassium-efflux system ancillary protein KefG YP_404982.1 3247648 R 300267 CDS YP_404983.1 82778634 3797803 3248330..3250243 1 NC_007606.1 Code: R; COG: COG0488; ABC transporter ATP-binding protein 3250243 yheS 3797803 yheS Shigella dysenteriae Sd197 ABC transporter ATP-binding protein YP_404983.1 3248330 D 300267 CDS YP_404984.1 82778635 3797804 3250243..3251265 1 NC_007606.1 Code: R; COG: COG0429; hydrolase 3251265 yheT 3797804 yheT Shigella dysenteriae Sd197 hydrolase YP_404984.1 3250243 D 300267 CDS YP_404985.1 82778636 3797805 3251259..3251477 1 NC_007606.1 Code: S; COG: COG3089; hypothetical protein 3251477 yheU 3797805 yheU Shigella dysenteriae Sd197 hypothetical protein YP_404985.1 3251259 D 300267 CDS YP_404986.1 82778637 3798119 complement(3252456..3252860) 1 NC_007606.1 Code: O; COG: COG1765; hypothetical protein 3252860 yhfA 3798119 yhfA Shigella dysenteriae Sd197 hypothetical protein YP_404986.1 3252456 R 300267 CDS YP_404987.1 82778638 3798120 3253162..3253794 1 NC_007606.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3253794 crp 3798120 crp Shigella dysenteriae Sd197 cAMP-regulatory protein YP_404987.1 3253162 D 300267 CDS YP_404988.1 82778639 3798121 3253845..3255935 1 NC_007606.1 Code: S; COG: COG1289; hypothetical protein 3255935 yhfK 3798121 yhfK Shigella dysenteriae Sd197 hypothetical protein YP_404988.1 3253845 D 300267 CDS YP_404989.1 82778640 3798122 complement(3256002..3257222) 1 NC_007606.1 ''DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate''; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 3257222 argD 3798122 argD Shigella dysenteriae Sd197 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase YP_404989.1 3256002 R 300267 CDS YP_404990.1 82778641 3798123 complement(3257308..3257871) 1 NC_007606.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3257871 pabA 3798123 pabA Shigella dysenteriae Sd197 para-aminobenzoate synthase component II YP_404990.1 3257308 R 300267 CDS YP_404991.1 82778642 3798124 complement(3257903..3258505) 1 NC_007606.1 induced in stationary phase, recognized by rpoS, affects cell division; Code: D; COG: COG2184; cell filamentation protein Fic 3258505 fic 3798124 fic Shigella dysenteriae Sd197 cell filamentation protein Fic YP_404991.1 3257903 R 300267 CDS YP_404992.1 82778643 3798125 complement(3258495..3258662) 1 NC_007606.1 hypothetical protein 3258662 yhfG 3798125 yhfG Shigella dysenteriae Sd197 hypothetical protein YP_404992.1 3258495 R 300267 CDS YP_404993.1 82778644 3798126 complement(3258767..3259339) 1 NC_007606.1 rotamase A; Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase A 3259339 ppiA 3798126 ppiA Shigella dysenteriae Sd197 peptidyl-prolyl cis-trans isomerase A YP_404993.1 3258767 R 300267 CDS YP_404994.1 82778645 3798127 3259610..3260791 1 NC_007606.1 Code: GEPR; COG: COG0477; hypothetical protein 3260791 yhfC 3798127 yhfC Shigella dysenteriae Sd197 hypothetical protein YP_404994.1 3259610 D 300267 CDS YP_404995.1 82778646 3798128 3261053..3263596 1 NC_007606.1 Code: C; COG: COG1251; nitrite reductase (NAD(P)H) subunit 3263596 nirB 3798128 nirB Shigella dysenteriae Sd197 nitrite reductase (NAD(P)H) subunit YP_404995.1 3261053 D 300267 CDS YP_404996.1 82778647 3798129 3263593..3263919 1 NC_007606.1 ''involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations''; nitrite reductase small subunit 3263919 nirD 3798129 nirD Shigella dysenteriae Sd197 nitrite reductase small subunit YP_404996.1 3263593 D 300267 CDS YP_404997.1 82778648 3798130 3264045..3264851 1 NC_007606.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3264851 nirC 3798130 nirC Shigella dysenteriae Sd197 nitrite transporter NirC YP_404997.1 3264045 D 300267 CDS YP_404998.1 82778649 3798131 3264870..3266243 1 NC_007606.1 sirohaeme biosynthesis; ''multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin''; siroheme synthase 3266243 cysG 3798131 cysG Shigella dysenteriae Sd197 siroheme synthase YP_404998.1 3264870 D 300267 CDS YP_404999.1 82778650 3798132 complement(3266260..3266655) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3266655 3798132 SDY_3531 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_404999.1 3266260 R 300267 CDS YP_405000.1 82778651 3798133 3266877..3268271 1 NC_007606.1 Code: E; COG: COG0076; glutamate decarboxylase 3268271 gadA 3798133 gadA Shigella dysenteriae Sd197 glutamate decarboxylase YP_405000.1 3266877 D 300267 CDS YP_405001.1 82778652 3798134 3268639..3269463 1 NC_007606.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 3269463 yhiX 3798134 yhiX Shigella dysenteriae Sd197 DNA-binding transcriptional regulator GadX YP_405001.1 3268639 D 300267 CDS YP_405002.1 82778653 3798136 complement(3269965..3270360) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3270360 3798136 SDY_3535 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405002.1 3269965 R 300267 CDS YP_405004.1 82778655 3796766 complement(3271688..3274807) 1 NC_007606.1 Code: V; COG: COG0841; transport system permease 3274807 yhiV 3796766 yhiV Shigella dysenteriae Sd197 transport system permease YP_405004.1 3271688 R 300267 CDS YP_405005.1 82778656 3796767 complement(3274832..3275986) 1 NC_007606.1 ''with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds''; multidrug efflux system protein MdtE 3275986 yhiU 3796767 yhiU Shigella dysenteriae Sd197 multidrug efflux system protein MdtE YP_405005.1 3274832 R 300267 CDS YP_405006.1 82778657 3796768 complement(3276325..3276852) 1 NC_007606.1 Code: K; COG: COG2771; hypothetical protein 3276852 yhiE 3796768 yhiE Shigella dysenteriae Sd197 hypothetical protein YP_405006.1 3276325 R 300267 CDS YP_405007.1 82778658 3796769 3277570..3277845 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3277845 insA 3796769 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405007.1 3277570 D 300267 CDS YP_405008.1 82778659 3796770 3277890..3278267 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3278267 insB 3796770 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405008.1 3277890 D 300267 CDS YP_405009.1 82778660 3796771 complement(3278429..3279001) 1 NC_007606.1 Code: S; COG: COG3247; acid-resistance membrane protein 3279001 hdeD 3796771 hdeD Shigella dysenteriae Sd197 acid-resistance membrane protein YP_405009.1 3278429 R 300267 CDS YP_405010.1 82778661 3796772 3279256..3279588 1 NC_007606.1 inactive form; acid-resistance protein 3279588 hdeA 3796772 hdeA Shigella dysenteriae Sd197 acid-resistance protein YP_405010.1 3279256 D 300267 CDS YP_405011.1 82778662 3796773 3279692..3280030 1 NC_007606.1 acid-resistance protein 3280030 hdeB 3796773 hdeB Shigella dysenteriae Sd197 acid-resistance protein YP_405011.1 3279692 D 300267 CDS YP_405012.1 82778663 3796775 complement(3280366..3280761) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3280761 3796775 SDY_3546 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405012.1 3280366 R 300267 CDS YP_009000828.1 578793303 18263142 complement(3280788..3281060) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3281060 18263142 SDY_4756 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000828.1 3280788 R 300267 CDS YP_405013.1 82778664 3796776 complement(3281566..3282336) 1 NC_007606.1 with HmuTU is involved in the transport of hemin; hemin importer ATP-binding subunit 3282336 hmuV 3796776 hmuV Shigella dysenteriae Sd197 hemin importer ATP-binding subunit YP_405013.1 3281566 R 300267 CDS YP_405014.1 82778665 3796777 complement(3282333..3283289) 1 NC_007606.1 Code: P; COG: COG0609; iron compound ABC transporter permease 3283289 shuU 3796777 shuU Shigella dysenteriae Sd197 iron compound ABC transporter permease YP_405014.1 3282333 R 300267 CDS YP_405015.1 82778666 3796778 complement(3283376..3283999) 1 NC_007606.1 Code: MG; COG: COG0702; hypothetical protein 3283999 shuY 3796778 shuY Shigella dysenteriae Sd197 hypothetical protein YP_405015.1 3283376 R 300267 CDS YP_405016.1 82778667 3796779 complement(3283999..3284493) 1 NC_007606.1 Code: P; COG: COG3721; hypothetical protein 3284493 shuX 3796779 shuX Shigella dysenteriae Sd197 hypothetical protein YP_405016.1 3283999 R 300267 CDS YP_405017.1 82778668 3796781 complement(3285863..3286855) 1 NC_007606.1 Code: P; COG: COG4558; periplasmic binding protein 3286855 shuT 3796781 shuT Shigella dysenteriae Sd197 periplasmic binding protein YP_405017.1 3285863 R 300267 CDS YP_405018.1 82778669 3796782 3286885..3287181 1 NC_007606.1 hypothetical protein 3287181 3796782 SDY_3553 Shigella dysenteriae Sd197 hypothetical protein YP_405018.1 3286885 D 300267 CDS YP_405019.1 82778670 3796783 3287457..3289439 1 NC_007606.1 Code: P; COG: COG1629; outer membrane heme/hemoglobin receptor 3289439 shuA 3796783 shuA Shigella dysenteriae Sd197 outer membrane heme/hemoglobin receptor YP_405019.1 3287457 D 300267 CDS YP_405020.1 82778671 3796784 3289488..3290516 1 NC_007606.1 Code: P; COG: COG3720; heme/hemoglobin transport protein 3290516 shuS 3796784 shuS Shigella dysenteriae Sd197 heme/hemoglobin transport protein YP_405020.1 3289488 D 300267 CDS YP_405021.1 82778672 3799940 complement(3290577..3291107) 1 NC_007606.1 Code: K; COG: COG2771; hypothetical protein 3291107 yhiF 3799940 yhiF Shigella dysenteriae Sd197 hypothetical protein YP_405021.1 3290577 R 300267 CDS YP_405022.1 82778673 3799941 complement(3291263..3291862) 1 NC_007606.1 Code: M; COG: COG3065; hypothetical protein 3291862 slp 3799941 slp Shigella dysenteriae Sd197 hypothetical protein YP_405022.1 3291263 R 300267 CDS YP_009000829.1 578793304 18263143 3292224..3292496 1 NC_007606.1 insertion element iso-IS1N protein InsA 3292496 18263143 SDY_4757 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000829.1 3292224 D 300267 CDS YP_405023.1 82778674 3799942 3292523..3292918 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3292918 3799942 SDY_3558 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405023.1 3292523 D 300267 CDS YP_405024.1 82778675 3799943 complement(3293052..3293477) 1 NC_007606.1 Code: P; COG: COG1393; arsenate reductase 3293477 arsC 3799943 arsC Shigella dysenteriae Sd197 arsenate reductase YP_405024.1 3293052 R 300267 CDS YP_405025.1 82778676 3799944 complement(3293490..3294800) 1 NC_007606.1 Code: P; COG: COG1055; arsenical pump membrane protein 3294800 arsB 3799944 arsB Shigella dysenteriae Sd197 arsenical pump membrane protein YP_405025.1 3293490 R 300267 CDS YP_405026.1 82778677 3799945 complement(3294834..3295187) 1 NC_007606.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3295187 arsR 3799945 arsR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor ArsR YP_405026.1 3294834 R 300267 CDS YP_405027.1 82778678 3799946 complement(3296067..3297419) 1 NC_007606.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3297419 gor 3799946 gor Shigella dysenteriae Sd197 glutathione reductase YP_405027.1 3296067 R 300267 CDS YP_405028.1 82778679 3799947 complement(3297491..3298333) 1 NC_007606.1 Code: R; COG: COG2961; hypothetical protein 3298333 yhiR 3799947 yhiR Shigella dysenteriae Sd197 hypothetical protein YP_405028.1 3297491 R 300267 CDS YP_405029.1 82778680 3799948 3298536..3300578 1 NC_007606.1 Code: E; COG: COG0339; oligopeptidase A 3300578 prlC 3799948 prlC Shigella dysenteriae Sd197 oligopeptidase A YP_405029.1 3298536 D 300267 CDS YP_405030.1 82778681 3799949 3300584..3301336 1 NC_007606.1 predicted SAM-dependent methyltransferase; methyltransferase 3301336 yhiQ 3799949 yhiQ Shigella dysenteriae Sd197 methyltransferase YP_405030.1 3300584 D 300267 CDS YP_405032.1 82778683 3799951 complement(3303167..3303601) 1 NC_007606.1 Code: T; COG: COG0589; universal stress protein 3303601 uspA 3799951 uspA Shigella dysenteriae Sd197 universal stress protein YP_405032.1 3303167 R 300267 CDS YP_405033.1 82778684 3799952 3303992..3304327 1 NC_007606.1 ''ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress''; universal stress protein UspB 3304327 yhiO 3799952 yhiO Shigella dysenteriae Sd197 universal stress protein UspB YP_405033.1 3303992 D 300267 CDS YP_405034.1 82778685 3799953 complement(3304398..3305897) 1 NC_007606.1 Code: P; COG: COG0306; low-affinity phosphate transport protein 3305897 pitA 3799953 pitA Shigella dysenteriae Sd197 low-affinity phosphate transport protein YP_405034.1 3304398 R 300267 CDS YP_405035.1 82778686 3799954 3306129..3307331 1 NC_007606.1 Code: R; COG: COG2081; hypothetical protein 3307331 yhiN 3799954 yhiN Shigella dysenteriae Sd197 hypothetical protein YP_405035.1 3306129 D 300267 CDS YP_009000830.1 578793305 18263144 3307396..3307668 1 NC_007606.1 insertion element iso-IS1N protein InsA 3307668 18263144 SDY_4758 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000830.1 3307396 D 300267 CDS YP_405039.1 82778690 3799958 complement(3308987..3311434) 1 NC_007606.1 Code: G; COG: COG0058; glycogen phosphorylase 3311434 glgP 3799958 glgP Shigella dysenteriae Sd197 glycogen phosphorylase YP_405039.1 3308987 R 300267 CDS YP_405040.1 82778691 3799959 complement(3311453..3312886) 1 NC_007606.1 ''catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose''; glycogen synthase 3312886 glgA 3799959 glgA Shigella dysenteriae Sd197 glycogen synthase YP_405040.1 3311453 R 300267 CDS YP_405041.1 82778692 3798292 complement(3312886..3314181) 1 NC_007606.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3314181 glgC 3798292 glgC Shigella dysenteriae Sd197 glucose-1-phosphate adenylyltransferase YP_405041.1 3312886 R 300267 CDS YP_405042.1 82778693 3798293 complement(3314199..3316172) 1 NC_007606.1 part of glycogen operon, a glycosyl hydrolase, debranching enzyme; ''catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen''; glycogen debranching protein 3316172 glgX 3798293 glgX Shigella dysenteriae Sd197 glycogen debranching protein YP_405042.1 3314199 R 300267 CDS YP_405043.1 82778694 3798294 complement(3316169..3318355) 1 NC_007606.1 ''catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain''; glycogen branching protein 3318355 glgB 3798294 glgB Shigella dysenteriae Sd197 glycogen branching protein YP_405043.1 3316169 R 300267 CDS YP_405044.1 82778695 3798295 complement(3318628..3319731) 1 NC_007606.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3319731 asd 3798295 asd Shigella dysenteriae Sd197 aspartate-semialdehyde dehydrogenase YP_405044.1 3318628 R 300267 CDS YP_405045.1 82778696 3798296 3319923..3320516 1 NC_007606.1 ''YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP)''; dITP- and XTP- hydrolase 3320516 yhgN 3798296 yhgN Shigella dysenteriae Sd197 dITP- and XTP- hydrolase YP_405045.1 3319923 D 300267 CDS YP_405046.1 82778697 3798297 complement(3320562..3321857) 1 NC_007606.1 Code: LU; COG: COG0758; DNA processing protein 3321857 3798297 SDY_3581 Shigella dysenteriae Sd197 DNA processing protein YP_405046.1 3320562 R 300267 CDS YP_405047.1 82778698 3798298 complement(3322235..3322723) 1 NC_007606.1 hypothetical protein 3322723 3798298 SDY_3582 Shigella dysenteriae Sd197 hypothetical protein YP_405047.1 3322235 R 300267 CDS YP_009000831.1 578793306 18263145 3322703..3322975 1 NC_007606.1 insertion element iso-IS1N protein InsA 3322975 18263145 SDY_4759 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000831.1 3322703 D 300267 CDS YP_405048.1 82778699 3798299 3323002..3323397 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3323397 3798299 SDY_3583 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405048.1 3323002 D 300267 CDS YP_405049.1 82778700 3798300 3323545..3323820 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3323820 insA 3798300 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405049.1 3323545 D 300267 CDS YP_405050.1 82778701 3798301 3323865..3324242 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3324242 insB 3798301 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405050.1 3323865 D 300267 CDS YP_405051.1 82778702 3798302 complement(3324253..3325410) 1 NC_007606.1 Code: L; COG: COG0514; hypothetical protein 3325410 3798302 SDY_3586 Shigella dysenteriae Sd197 hypothetical protein YP_405051.1 3324253 R 300267 CDS YP_405052.1 82778703 3798303 complement(3325550..3326890) 1 NC_007606.1 Code: GE; COG: COG2610; low affinity gluconate transporter 3326890 gntU 3798303 gntU Shigella dysenteriae Sd197 low affinity gluconate transporter YP_405052.1 3325550 R 300267 CDS YP_405053.2 161950028 3798304 complement(3326894..3327421) 1 NC_007606.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 3327421 gntK 3798304 gntK Shigella dysenteriae Sd197 gluconate kinase YP_405053.2 3326894 R 300267 CDS YP_405054.1 82778705 3798305 complement(3327560..3328498) 1 NC_007606.1 regulator of gnt operon; Code: K; COG: COG1609; gluconate operon regulator 3328498 gntR 3798305 gntR Shigella dysenteriae Sd197 gluconate operon regulator YP_405054.1 3327560 R 300267 CDS YP_405055.1 82778706 3798306 complement(3328681..3329466) 1 NC_007606.1 Code: R; COG: COG1741; hypothetical protein 3329466 yhhW 3798306 yhhW Shigella dysenteriae Sd197 hypothetical protein YP_405055.1 3328681 R 300267 CDS YP_405056.1 82778707 3798307 complement(3329589..3330626) 1 NC_007606.1 Code: R; COG: COG0673; dehydrogenase 3330626 yhhX 3798307 yhhX Shigella dysenteriae Sd197 dehydrogenase YP_405056.1 3329589 R 300267 CDS YP_009000832.1 578793307 18263146 3331369..3331641 1 NC_007606.1 insertion element iso-IS1N protein InsA 3331641 18263146 SDY_4760 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000832.1 3331369 D 300267 CDS YP_405059.1 82778710 3796650 complement(3332237..3333982) 1 NC_007606.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 3333982 ggt 3796650 ggt Shigella dysenteriae Sd197 gamma-glutamyltranspeptidase YP_405059.1 3332237 R 300267 CDS YP_405060.1 82778711 3796651 3334102..3334542 1 NC_007606.1 hypothetical protein 3334542 yhhA 3796651 yhhA Shigella dysenteriae Sd197 hypothetical protein YP_405060.1 3334102 D 300267 CDS YP_405061.1 82778712 3796654 complement(3336330..3337175) 1 NC_007606.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate ABC transporter permease 3337175 ugpE 3796654 ugpE Shigella dysenteriae Sd197 glycerol-3-phosphate ABC transporter permease YP_405061.1 3336330 R 300267 CDS YP_405062.1 82778713 3796655 complement(3337172..3338059) 1 NC_007606.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate ABC transporter permease 3338059 ugpA 3796655 ugpA Shigella dysenteriae Sd197 glycerol-3-phosphate ABC transporter permease YP_405062.1 3337172 R 300267 CDS YP_405063.1 82778714 3796656 complement(3338157..3339473) 1 NC_007606.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate ABC transporter substrate-binding protein 3339473 ugpB 3796656 ugpB Shigella dysenteriae Sd197 glycerol-3-phosphate ABC transporter substrate-binding protein YP_405063.1 3338157 R 300267 CDS YP_405064.1 82778715 3796657 complement(3339833..3340579) 1 NC_007606.1 Code: S; COG: COG4700; hypothetical protein 3340579 3796657 SDY_3602 Shigella dysenteriae Sd197 hypothetical protein YP_405064.1 3339833 R 300267 CDS YP_405065.2 161950027 3796658 complement(3340698..3341411) 1 NC_007606.1 ''with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''; leucine/isoleucine/valine ABC transporter ATP-binding protein 3341411 livF 3796658 livF Shigella dysenteriae Sd197 leucine/isoleucine/valine ABC transporter ATP-binding protein YP_405065.2 3340698 R 300267 CDS YP_405066.1 82778717 3796659 complement(3341413..3342180) 1 NC_007606.1 ''Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''; leucine/isoleucine/valine ABC transporter ATP-binding protein 3342180 livG 3796659 livG Shigella dysenteriae Sd197 leucine/isoleucine/valine ABC transporter ATP-binding protein YP_405066.1 3341413 R 300267 CDS YP_405067.1 82778718 3796660 complement(3342177..3343454) 1 NC_007606.1 ''Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''; leucine/isoleucine/valine ABC transporter permease 3343454 livM 3796660 livM Shigella dysenteriae Sd197 leucine/isoleucine/valine ABC transporter permease YP_405067.1 3342177 R 300267 CDS YP_405068.1 82778719 3796661 complement(3343451..3344299) 1 NC_007606.1 Code: E; COG: COG0559; high-affinity branched-chain amino acid transport system permease 3344299 livH 3796661 livH Shigella dysenteriae Sd197 high-affinity branched-chain amino acid transport system permease YP_405068.1 3343451 R 300267 CDS YP_405069.1 82778720 3796662 complement(3344347..3345456) 1 NC_007606.1 Code: E; COG: COG0683; high-affinity leucine-specific transport system substrate-binding protein 3345456 livK 3796662 livK Shigella dysenteriae Sd197 high-affinity leucine-specific transport system substrate-binding protein YP_405069.1 3344347 R 300267 CDS YP_405070.1 82778721 3796663 complement(3345525..3345902) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3345902 insB 3796663 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405070.1 3345525 R 300267 CDS YP_405071.1 82778722 3796664 complement(3345947..3346222) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3346222 insA 3796664 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405071.1 3345947 R 300267 CDS YP_405072.1 82778723 3796665 3346657..3347040 1 NC_007606.1 hypothetical protein 3347040 yhhK 3796665 yhhK Shigella dysenteriae Sd197 hypothetical protein YP_405072.1 3346657 D 300267 CDS YP_405073.1 82778724 3796666 complement(3347240..3348400) 1 NC_007606.1 Code: E; COG: COG0683; high-affinity amino acid transport system substrate-binding protein 3348400 livJ 3796666 livJ Shigella dysenteriae Sd197 high-affinity amino acid transport system substrate-binding protein YP_405073.1 3347240 R 300267 CDS YP_405074.1 82778725 3796667 complement(3348614..3349468) 1 NC_007606.1 regulation of proteins induced at high temperatures; binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3349468 rpoH 3796667 rpoH Shigella dysenteriae Sd197 RNA polymerase factor sigma-32 YP_405074.1 3348614 R 300267 CDS YP_405075.1 82778726 3796668 complement(3349713..3350771) 1 NC_007606.1 ''ABC transporter, membrane protein''; cell division protein FtsX 3350771 ftsX 3796668 ftsX Shigella dysenteriae Sd197 cell division protein FtsX YP_405075.1 3349713 R 300267 CDS YP_405076.1 82778727 3796669 complement(3350764..3351432) 1 NC_007606.1 ''ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions''; cell division protein FtsE 3351432 ftsE 3796669 ftsE Shigella dysenteriae Sd197 cell division protein FtsE YP_405076.1 3350764 R 300267 CDS YP_405077.1 82778728 3797860 complement(3351435..3352931) 1 NC_007606.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 3352931 ftsY 3797860 ftsY Shigella dysenteriae Sd197 cell division protein FtsY YP_405077.1 3351435 R 300267 CDS YP_405078.1 82778729 3797861 3353081..3353677 1 NC_007606.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3353677 rsmD 3797861 rsmD Shigella dysenteriae Sd197 16S rRNA m(2)G966-methyltransferase YP_405078.1 3353081 D 300267 CDS YP_405079.1 82778730 3797862 3353667..3353936 1 NC_007606.1 Code: S; COG: COG3776; hypothetical protein 3353936 yhhL 3797862 yhhL Shigella dysenteriae Sd197 hypothetical protein YP_405079.1 3353667 D 300267 CDS YP_405080.1 82778731 3797863 complement(3353939..3354298) 1 NC_007606.1 receptor 3354298 yhhM 3797863 yhhM Shigella dysenteriae Sd197 receptor YP_405080.1 3353939 R 300267 CDS YP_405081.1 82778732 3797865 3355139..3357337 1 NC_007606.1 ''P-type ATPase involved in the export of lead, cadmium, zinc and mercury''; zinc/cadmium/mercury/lead-transporting ATPase 3357337 zntA 3797865 zntA Shigella dysenteriae Sd197 zinc/cadmium/mercury/lead-transporting ATPase YP_405081.1 3355139 D 300267 CDS YP_405082.1 82778733 3797866 complement(3357439..3357684) 1 NC_007606.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3357684 yhhP 3797866 yhhP Shigella dysenteriae Sd197 sulfur transfer protein SirA YP_405082.1 3357439 R 300267 CDS YP_405083.1 82778734 3797867 3357905..3358570 1 NC_007606.1 Code: S; COG: COG1738; hypothetical protein 3358570 yhhQ 3797867 yhhQ Shigella dysenteriae Sd197 hypothetical protein YP_405083.1 3357905 D 300267 CDS YP_405084.2 161950026 3797868 3358643..3359200 1 NC_007606.1 hypothetical protein 3359200 3797868 SDY_3623 Shigella dysenteriae Sd197 hypothetical protein YP_405084.2 3358643 D 300267 CDS YP_405086.1 82778737 3797871 3361513..3361908 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3361908 3797871 SDY_3626 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405086.1 3361513 D 300267 CDS YP_405087.1 82778738 3797872 complement(3362363..3362740) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3362740 insB 3797872 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405087.1 3362363 R 300267 CDS YP_405088.1 82778739 3797873 complement(3362785..3363060) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3363060 insA 3797873 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405088.1 3362785 R 300267 CDS YP_405089.1 82778740 3797874 3363131..3364360 1 NC_007606.1 ''FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''; 3-oxoacyl-ACP synthase 3364360 3797874 SDY_3629 Shigella dysenteriae Sd197 3-oxoacyl-ACP synthase YP_405089.1 3363131 D 300267 CDS YP_405090.1 82778741 3797875 3364362..3364949 1 NC_007606.1 Code: H; COG: COG2091; holo-(acyl carrier protein) synthase 2 3364949 yhhU 3797875 yhhU Shigella dysenteriae Sd197 holo-(acyl carrier protein) synthase 2 YP_405090.1 3364362 D 300267 CDS YP_405091.1 82778742 3797876 3365060..3366634 1 NC_007606.1 Code: E; COG: COG0747; nickel periplasmic binding protein 3366634 nikA 3797876 nikA Shigella dysenteriae Sd197 nickel periplasmic binding protein YP_405091.1 3365060 D 300267 CDS YP_405092.1 82778743 3797877 3366634..3367578 1 NC_007606.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3367578 nikB 3797877 nikB Shigella dysenteriae Sd197 nickel transporter permease NikB YP_405092.1 3366634 D 300267 CDS YP_405093.1 82778744 3797878 3367575..3368408 1 NC_007606.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3368408 nikC 3797878 nikC Shigella dysenteriae Sd197 nickel transporter permease NikC YP_405093.1 3367575 D 300267 CDS YP_405094.1 82778745 3797806 3368408..3369172 1 NC_007606.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3369172 nikD 3797806 nikD Shigella dysenteriae Sd197 nickel transporter ATP-binding protein NikD YP_405094.1 3368408 D 300267 CDS YP_405095.1 82778746 3797807 3369169..3369975 1 NC_007606.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3369975 nikE 3797807 nikE Shigella dysenteriae Sd197 nickel transporter ATP-binding protein NikE YP_405095.1 3369169 D 300267 CDS YP_405096.1 82778747 3797808 3369981..3370382 1 NC_007606.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3370382 yhhG 3797808 yhhG Shigella dysenteriae Sd197 nickel responsive regulator YP_405096.1 3369981 D 300267 CDS YP_009000833.1 578793308 18263147 3370872..3371144 1 NC_007606.1 insertion element iso-IS1N protein InsA 3371144 18263147 SDY_4761 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000833.1 3370872 D 300267 CDS YP_405098.2 161950025 3797811 complement(3372022..3372417) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3372417 3797811 SDY_3639 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405098.2 3372022 R 300267 CDS YP_009000834.1 578793309 18263148 complement(3372444..3372716) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3372716 18263148 SDY_4762 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000834.1 3372444 R 300267 CDS YP_405100.1 82778751 3797813 3372900..3373373 1 NC_007606.1 Code: GT; COG: COG1762; PTS system transporter subunit IIA 3373373 3797813 SDY_3641 Shigella dysenteriae Sd197 PTS system transporter subunit IIA YP_405100.1 3372900 D 300267 CDS YP_405101.1 82778752 3797814 3373370..3373651 1 NC_007606.1 Code: G; COG: COG3414; PTS system transporter subunit IIB 3373651 3797814 SDY_3642 Shigella dysenteriae Sd197 PTS system transporter subunit IIB YP_405101.1 3373370 D 300267 CDS YP_405102.1 82778753 3797815 3373728..3374111 1 NC_007606.1 hypothetical protein 3374111 3797815 SDY_3643 Shigella dysenteriae Sd197 hypothetical protein YP_405102.1 3373728 D 300267 CDS YP_405103.1 82778754 3797816 3374220..3374495 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3374495 insA 3797816 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405103.1 3374220 D 300267 CDS YP_405104.1 82778755 3797817 3374540..3374917 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3374917 insB 3797817 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405104.1 3374540 D 300267 CDS YP_405105.1 82778756 3797818 3374999..3375532 1 NC_007606.1 hypothetical protein 3375532 3797818 SDY_3646 Shigella dysenteriae Sd197 hypothetical protein YP_405105.1 3374999 D 300267 CDS YP_405108.1 82778759 3797821 complement(3377119..3378624) 1 NC_007606.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3378624 glpD 3797821 glpD Shigella dysenteriae Sd197 glycerol-3-phosphate dehydrogenase YP_405108.1 3377119 R 300267 CDS YP_405109.1 82778760 3797822 3378814..3379140 1 NC_007606.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3379140 glpE 3797822 glpE Shigella dysenteriae Sd197 thiosulfate sulfurtransferase YP_405109.1 3378814 D 300267 CDS YP_405110.1 82778761 3797823 3379185..3380015 1 NC_007606.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3380015 glpG 3797823 glpG Shigella dysenteriae Sd197 intramembrane serine protease GlpG YP_405110.1 3379185 D 300267 CDS YP_405111.1 82778762 3797824 3380032..3380790 1 NC_007606.1 ''represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism''; DNA-binding transcriptional repressor GlpR 3380790 glpR 3797824 glpR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor GlpR YP_405111.1 3380032 D 300267 CDS YP_405112.1 82778763 3796710 3381782..3382813 1 NC_007606.1 ''catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester''; RNA 3'-terminal-phosphate cyclase 3382813 yhgKJ 3796710 yhgKJ Shigella dysenteriae Sd197 RNA 3'-terminal-phosphate cyclase YP_405112.1 3381782 D 300267 CDS YP_405113.1 82778764 3796711 complement(3382863..3383348) 1 NC_007606.1 Code: KR; COG: COG0454; hypothetical protein 3383348 3796711 SDY_3656 Shigella dysenteriae Sd197 hypothetical protein YP_405113.1 3382863 R 300267 CDS YP_405114.1 82778765 3796712 complement(3383339..3383623) 1 NC_007606.1 Code: S; COG: COG4453; hypothetical protein 3383623 3796712 SDY_3657 Shigella dysenteriae Sd197 hypothetical protein YP_405114.1 3383339 R 300267 CDS YP_405115.1 82778766 3796713 complement(3383684..3386383) 1 NC_007606.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3386383 malT 3796713 malT Shigella dysenteriae Sd197 transcriptional regulator MalT YP_405115.1 3383684 R 300267 CDS YP_405116.1 82778767 3796714 3386995..3389388 1 NC_007606.1 Code: G; COG: COG0058; maltodextrin phosphorylase 3389388 malP 3796714 malP Shigella dysenteriae Sd197 maltodextrin phosphorylase YP_405116.1 3386995 D 300267 CDS YP_405117.1 82778768 3796715 3389398..3391482 1 NC_007606.1 amylomaltase; amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3391482 malQ 3796715 malQ Shigella dysenteriae Sd197 4-alpha-glucanotransferase YP_405117.1 3389398 D 300267 CDS YP_405118.1 82778769 3796716 complement(3391527..3392843) 1 NC_007606.1 Code: GE; COG: COG2610; high-affinity gluconate/gluconate transporter permease 3392843 gntT 3796716 gntT Shigella dysenteriae Sd197 high-affinity gluconate/gluconate transporter permease YP_405118.1 3391527 R 300267 CDS YP_405119.1 82778770 3796717 complement(3393204..3393779) 1 NC_007606.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 3393779 yhgI 3796717 yhgI Shigella dysenteriae Sd197 DNA uptake protein YP_405119.1 3393204 R 300267 CDS YP_405120.1 82778771 3796718 3394545..3395315 1 NC_007606.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3395315 bioH 3796718 bioH Shigella dysenteriae Sd197 carboxylesterase BioH YP_405120.1 3394545 D 300267 CDS YP_405121.1 82778772 3796720 complement(3395342..3396220) 1 NC_007606.1 Code: S; COG: COG5464; hypothetical protein 3396220 yhgA 3796720 yhgA Shigella dysenteriae Sd197 hypothetical protein YP_405121.1 3395342 R 300267 CDS YP_405122.1 82778773 3796721 complement(3396423..3396659) 1 NC_007606.1 hypothetical protein 3396659 yhgG 3796721 yhgG Shigella dysenteriae Sd197 hypothetical protein YP_405122.1 3396423 R 300267 CDS YP_405123.1 82778774 3796722 complement(3396659..3398980) 1 NC_007606.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3398980 feoB 3796722 feoB Shigella dysenteriae Sd197 ferrous iron transport protein B YP_405123.1 3396659 R 300267 CDS YP_405124.1 82778775 3796723 complement(3398997..3399224) 1 NC_007606.1 Code: P; COG: COG1918; ferrous iron transport protein A 3399224 feoA 3796723 feoA Shigella dysenteriae Sd197 ferrous iron transport protein A YP_405124.1 3398997 R 300267 CDS YP_405125.1 82778776 3796724 complement(3399681..3401903) 1 NC_007606.1 Code: K; COG: COG2183; hypothetical protein 3401903 yhgF 3796724 yhgF Shigella dysenteriae Sd197 hypothetical protein YP_405125.1 3399681 R 300267 CDS YP_405126.1 82778777 3796725 complement(3402099..3402575) 1 NC_007606.1 ''necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus''; transcription elongation factor GreB 3402575 greB 3796725 greB Shigella dysenteriae Sd197 transcription elongation factor GreB YP_405126.1 3402099 R 300267 CDS YP_405127.1 82778778 3796726 3402803..3403522 1 NC_007606.1 sensor, EnvZ; outer membrane protein synthesis; part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3403522 ompR 3796726 ompR Shigella dysenteriae Sd197 osmolarity response regulator YP_405127.1 3402803 D 300267 CDS YP_405128.1 82778779 3796727 3403519..3404871 1 NC_007606.1 modulates expression of ompF and ompC; membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3404871 envZ 3796727 envZ Shigella dysenteriae Sd197 osmolarity sensor protein YP_405128.1 3403519 D 300267 CDS YP_405129.1 82778780 3797748 complement(3404947..3406569) 1 NC_007606.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3406569 pckA 3797748 pckA Shigella dysenteriae Sd197 phosphoenolpyruvate carboxykinase YP_405129.1 3404947 R 300267 CDS YP_405130.1 82778781 3797749 3406949..3408673 1 NC_007606.1 transporter 3408673 yhgE 3797749 yhgE Shigella dysenteriae Sd197 transporter YP_405130.1 3406949 D 300267 CDS YP_009000835.1 578793310 18263149 complement(3409164..3409436) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3409436 18263149 SDY_4763 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000835.1 3409164 R 300267 CDS YP_405133.2 161950024 3797752 complement(3409509..3410387) 1 NC_007606.1 ''becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers''; heat shock protein 33 3410387 hslO 3797752 hslO Shigella dysenteriae Sd197 heat shock protein 33 YP_405133.2 3409509 R 300267 CDS YP_405134.1 82778785 3797753 complement(3410412..3410813) 1 NC_007606.1 Code: J; COG: COG1188; ribosome-associated heat shock protein Hsp15 3410813 yrfH 3797753 yrfH Shigella dysenteriae Sd197 ribosome-associated heat shock protein Hsp15 YP_405134.1 3410412 R 300267 CDS YP_405135.1 82778786 3797754 complement(3410824..3411537) 1 NC_007606.1 Code: R; COG: COG1011; phosphatase 3411537 yrfG 3797754 yrfG Shigella dysenteriae Sd197 phosphatase YP_405135.1 3410824 R 300267 CDS YP_405136.1 82778787 3797755 complement(3411557..3413692) 1 NC_007606.1 dehydrogenase 3413692 yrfF 3797755 yrfF Shigella dysenteriae Sd197 dehydrogenase YP_405136.1 3411557 R 300267 CDS YP_405137.1 82778788 3797756 3414012..3414572 1 NC_007606.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3414572 nudE 3797756 nudE Shigella dysenteriae Sd197 ADP-ribose diphosphatase NudE YP_405137.1 3414012 D 300267 CDS YP_405138.2 228861759 3797757 complement(3414737..3417289) 1 NC_007606.1 penicillin-binding protein 1A; bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3417289 mrcA 3797757 mrcA Shigella dysenteriae Sd197 peptidoglycan synthetase YP_405138.2 3414737 R 300267 CDS YP_405141.1 82778792 3797760 3418188..3418727 1 NC_007606.1 Code: NU; COG: COG3166; hypothetical protein 3418727 yrfC 3797760 yrfC Shigella dysenteriae Sd197 hypothetical protein YP_405141.1 3418188 D 300267 CDS YP_405142.1 82778793 3797761 3418711..3419091 1 NC_007606.1 hypothetical protein 3419091 yrfB 3797761 yrfB Shigella dysenteriae Sd197 hypothetical protein YP_405142.1 3418711 D 300267 CDS YP_405143.1 82778794 3797762 3419101..3419544 1 NC_007606.1 hypothetical protein 3419544 yrfA 3797762 yrfA Shigella dysenteriae Sd197 hypothetical protein YP_405143.1 3419101 D 300267 CDS YP_405144.1 82778795 3797764 3421095..3421616 1 NC_007606.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3421616 aroK 3797764 aroK Shigella dysenteriae Sd197 shikimate kinase I YP_405144.1 3421095 D 300267 CDS YP_405145.1 82778796 3797765 3421673..3422761 1 NC_007606.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3422761 aroB 3797765 aroB Shigella dysenteriae Sd197 3-dehydroquinate synthase YP_405145.1 3421673 D 300267 CDS YP_405146.1 82778797 3797766 3422853..3424130 1 NC_007606.1 interferes with cell division; Code: S; COG: COG3266; hypothetical protein 3424130 damX 3797766 damX Shigella dysenteriae Sd197 hypothetical protein YP_405146.1 3422853 D 300267 CDS YP_405147.1 82778798 3797767 3424237..3425073 1 NC_007606.1 Code: L; COG: COG0338; DNA adenine methylase 3425073 dam 3797767 dam Shigella dysenteriae Sd197 DNA adenine methylase YP_405147.1 3424237 D 300267 CDS YP_405148.1 82778799 3798138 3425091..3425768 1 NC_007606.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3425768 rpe 3798138 rpe Shigella dysenteriae Sd197 ribulose-phosphate 3-epimerase YP_405148.1 3425091 D 300267 CDS YP_405149.1 82778800 3798139 3425761..3426519 1 NC_007606.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3426519 gph 3798139 gph Shigella dysenteriae Sd197 phosphoglycolate phosphatase YP_405149.1 3425761 D 300267 CDS YP_405150.1 82778801 3798140 3426512..3427516 1 NC_007606.1 ''catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''; tryptophanyl-tRNA synthetase 3427516 trpS 3798140 trpS Shigella dysenteriae Sd197 tryptophanyl-tRNA synthetase YP_405150.1 3426512 D 300267 CDS YP_405151.2 578793311 3798141 3427784..3428689 1 NC_007606.1 hypothetical protein 3428689 yhfZ 3798141 yhfZ Shigella dysenteriae Sd197 hypothetical protein YP_405151.2 3427784 D 300267 CDS YP_405152.1 82778803 3798143 3428847..3429212 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 3429212 3798143 SDY_3698 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_405152.1 3428847 D 300267 CDS YP_405153.2 161950023 3798144 3429170..3430075 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3430075 3798144 SDY_3699 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405153.2 3429170 D 300267 CDS YP_405154.1 82778805 3798146 3431652..3432878 1 NC_007606.1 Code: G; COG: COG1015; mutase 3432878 yhfW 3798146 yhfW Shigella dysenteriae Sd197 mutase YP_405154.1 3431652 D 300267 CDS YP_405155.1 82778806 3798147 3432875..3433753 1 NC_007606.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 3433753 yhfV 3798147 yhfV Shigella dysenteriae Sd197 hydrolase YP_405155.1 3432875 D 300267 CDS YP_405156.1 82778807 3798149 complement(3434305..3434700) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3434700 3798149 SDY_3704 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405156.1 3434305 R 300267 CDS YP_009000836.1 578793312 18263150 complement(3434727..3434999) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3434999 18263150 SDY_4764 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000836.1 3434727 R 300267 CDS YP_405157.1 82778808 3798150 3434922..3435623 1 NC_007606.1 Code: K; COG: COG2207; transcriptional regulator 3435623 3798150 SDY_3705 Shigella dysenteriae Sd197 transcriptional regulator YP_405157.1 3434922 D 300267 CDS YP_405158.1 82778809 3798151 3435867..3436340 1 NC_007606.1 Code: C; COG: COG1142; hypothetical protein 3436340 yiaI 3798151 yiaI Shigella dysenteriae Sd197 hypothetical protein YP_405158.1 3435867 D 300267 CDS YP_405159.1 82778810 3798152 complement(3436379..3437632) 1 NC_007606.1 transaminase C; ''transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis''; valine--pyruvate transaminase 3437632 avtA 3798152 avtA Shigella dysenteriae Sd197 valine--pyruvate transaminase YP_405159.1 3436379 R 300267 CDS YP_405160.1 82778811 3798154 3440160..3440984 1 NC_007606.1 Code: R; COG: COG2992; hypothetical protein 3440984 bax 3798154 bax Shigella dysenteriae Sd197 hypothetical protein YP_405160.1 3440160 D 300267 CDS YP_405161.1 82778812 3798155 complement(3441092..3442270) 1 NC_007606.1 Code: K; COG: COG1609; xyl operon regulator 3442270 xylR 3798155 xylR Shigella dysenteriae Sd197 xyl operon regulator YP_405161.1 3441092 R 300267 CDS YP_009000837.1 578793313 18263151 complement(3442777..3443049) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3443049 18263151 SDY_4765 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000837.1 3442777 R 300267 CDS YP_405167.1 82778818 3797210 3450399..3451988 1 NC_007606.1 AICAR formyltransferase; IMP cyclohydrolase; involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 3451988 purH 3797210 purH Shigella dysenteriae Sd197 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_405167.1 3450399 D 300267 CDS YP_405168.1 82778819 3797211 3452000..3453289 1 NC_007606.1 GAR synthetase; catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 3453289 purD 3797211 purD Shigella dysenteriae Sd197 phosphoribosylamine--glycine ligase YP_405168.1 3452000 D 300267 CDS YP_405169.1 82778820 3797212 complement(3453286..3454611) 1 NC_007606.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulator ZraR 3454611 hydG 3797212 hydG Shigella dysenteriae Sd197 transcriptional regulator ZraR YP_405169.1 3453286 R 300267 CDS YP_405170.1 82778821 3797213 complement(3454608..3455984) 1 NC_007606.1 Code: T; COG: COG0642; sensor protein ZraS 3455984 hydH 3797213 hydH Shigella dysenteriae Sd197 sensor protein ZraS YP_405170.1 3454608 R 300267 CDS YP_405171.2 161950022 3797214 3456222..3456641 1 NC_007606.1 Code: UNTP; COG: COG3678; zinc resistance protein 3456641 zraP 3797214 zraP Shigella dysenteriae Sd197 zinc resistance protein YP_405171.2 3456222 D 300267 CDS YP_405172.1 82778823 3797215 complement(3456643..3457338) 1 NC_007606.1 hypothetical protein 3457338 yjaH 3797215 yjaH Shigella dysenteriae Sd197 hypothetical protein YP_405172.1 3456643 R 300267 CDS YP_405173.1 82778824 3797216 complement(3457351..3457623) 1 NC_007606.1 HU-2; histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 3457623 hupA 3797216 hupA Shigella dysenteriae Sd197 transcriptional regulator HU subunit alpha YP_405173.1 3457351 R 300267 CDS YP_405174.1 82778825 3797217 complement(3457810..3458400) 1 NC_007606.1 Code: S; COG: COG3068; hypothetical protein 3458400 yjaG 3797217 yjaG Shigella dysenteriae Sd197 hypothetical protein YP_405174.1 3457810 R 300267 CDS YP_405175.1 82778826 3798272 complement(3458443..3459114) 1 NC_007606.1 deoxyinosine 3'endoduclease; ''Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures''; endonuclease V 3459114 nfi 3798272 nfi Shigella dysenteriae Sd197 endonuclease V YP_405175.1 3458443 R 300267 CDS YP_405176.1 82778827 3798273 complement(3459124..3460188) 1 NC_007606.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 3460188 hemE 3798273 hemE Shigella dysenteriae Sd197 uroporphyrinogen decarboxylase YP_405176.1 3459124 R 300267 CDS YP_405177.1 82778828 3798274 complement(3460228..3461001) 1 NC_007606.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 3461001 nudC 3798274 nudC Shigella dysenteriae Sd197 NADH pyrophosphatase YP_405177.1 3460228 R 300267 CDS YP_405178.1 82778829 3798275 3461096..3461572 1 NC_007606.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 3461572 yjaE 3798275 yjaE Shigella dysenteriae Sd197 anti-RNA polymerase sigma 70 factor YP_405178.1 3461096 D 300267 CDS YP_405179.1 82778830 3798276 3461806..3463701 1 NC_007606.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 3463701 thiC 3798276 thiC Shigella dysenteriae Sd197 thiamine biosynthesis protein ThiC YP_405179.1 3461806 D 300267 CDS YP_405180.1 82778831 3798277 3463701..3464336 1 NC_007606.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 3464336 thiE 3798277 thiE Shigella dysenteriae Sd197 thiamine-phosphate pyrophosphorylase YP_405180.1 3463701 D 300267 CDS YP_405181.2 161950021 3798278 3464329..3465084 1 NC_007606.1 Code: H; COG: COG0476; thiazole biosynthesis adenylyltransferase ThiF 3465084 thiF 3798278 thiF Shigella dysenteriae Sd197 thiazole biosynthesis adenylyltransferase ThiF YP_405181.2 3464329 D 300267 CDS YP_405182.1 82778833 3798279 3465068..3465268 1 NC_007606.1 ''with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate''; sulfur carrier protein ThiS 3465268 thiS 3798279 thiS Shigella dysenteriae Sd197 sulfur carrier protein ThiS YP_405182.1 3465068 D 300267 CDS YP_405183.2 161950020 3798280 3465270..3466040 1 NC_007606.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 3466040 thiG 3798280 thiG Shigella dysenteriae Sd197 thiazole synthase YP_405183.2 3465270 D 300267 CDS YP_405184.1 82778835 3798281 3466037..3467170 1 NC_007606.1 ''in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center''; thiamine biosynthesis protein ThiH 3467170 thiH 3798281 thiH Shigella dysenteriae Sd197 thiamine biosynthesis protein ThiH YP_405184.1 3466037 D 300267 CDS YP_009000838.1 578793314 18263152 3467840..3468112 1 NC_007606.1 insertion element iso-IS1N protein InsA 3468112 18263152 SDY_4766 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000838.1 3467840 D 300267 CDS YP_405185.1 82778836 3798282 3468139..3468534 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3468534 3798282 SDY_3738 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405185.1 3468139 D 300267 CDS YP_405186.1 82778837 3798284 complement(3469106..3473329) 1 NC_007606.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 3473329 rpoC 3798284 rpoC Shigella dysenteriae Sd197 DNA-directed RNA polymerase subunit beta' YP_405186.1 3469106 R 300267 CDS YP_405187.1 82778838 3798285 complement(3473406..3477434) 1 NC_007606.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 3477434 rpoB 3798285 rpoB Shigella dysenteriae Sd197 DNA-directed RNA polymerase subunit beta YP_405187.1 3473406 R 300267 CDS YP_405188.1 82778839 3798286 complement(3477743..3478108) 1 NC_007606.1 ''present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors''; 50S ribosomal protein L7/L12 3478108 rplL 3798286 rplL Shigella dysenteriae Sd197 50S ribosomal protein L7/L12 YP_405188.1 3477743 R 300267 CDS YP_405189.1 82778840 3798287 complement(3478175..3478672) 1 NC_007606.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 3478672 rplJ 3798287 rplJ Shigella dysenteriae Sd197 50S ribosomal protein L10 YP_405189.1 3478175 R 300267 CDS YP_405190.1 82778841 3798288 complement(3479085..3479789) 1 NC_007606.1 regulates synthesis of L1 and L11; ''in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA''; 50S ribosomal protein L1 3479789 rplA 3798288 rplA Shigella dysenteriae Sd197 50S ribosomal protein L1 YP_405190.1 3479085 R 300267 CDS YP_405191.1 82778842 3798289 complement(3479793..3480221) 1 NC_007606.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 3480221 rplK 3798289 rplK Shigella dysenteriae Sd197 50S ribosomal protein L11 YP_405191.1 3479793 R 300267 CDS YP_405192.1 82778843 3798290 complement(3480380..3480925) 1 NC_007606.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 3480925 nusG 3798290 nusG Shigella dysenteriae Sd197 transcription antitermination protein NusG YP_405192.1 3480380 R 300267 CDS YP_405193.1 82778844 3798291 complement(3480927..3481310) 1 NC_007606.1 ''forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force''; preprotein translocase subunit SecE 3481310 secE 3798291 secE Shigella dysenteriae Sd197 preprotein translocase subunit SecE YP_405193.1 3480927 R 300267 CDS YP_405194.1 82778845 3797937 complement(3481540..3482724) 1 NC_007606.1 ''EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu''; elongation factor Tu 3482724 tufB 3797937 tufB Shigella dysenteriae Sd197 elongation factor Tu YP_405194.1 3481540 R 300267 CDS YP_405196.1 82778847 3797943 3483642..3484592 1 NC_007606.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 3484592 coaA 3797943 coaA Shigella dysenteriae Sd197 pantothenate kinase YP_405196.1 3483642 D 300267 CDS YP_405197.1 82778848 3797944 complement(3484621..3485586) 1 NC_007606.1 ''catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon''; biotin--protein ligase 3485586 birA 3797944 birA Shigella dysenteriae Sd197 biotin--protein ligase YP_405197.1 3484621 R 300267 CDS YP_405198.1 82778849 3797945 complement(3485583..3486611) 1 NC_007606.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 3486611 murB 3797945 murB Shigella dysenteriae Sd197 UDP-N-acetylenolpyruvoylglucosamine reductase YP_405198.1 3485583 R 300267 CDS YP_405199.2 161950019 3798619 complement(3492121..3492978) 1 NC_007606.1 required for biosynthesis of D-glutamate and peptidoglycan; ''converts L-glutamate to D-glutamate, a component of peptidoglycan''; glutamate racemase 3492978 murI 3798619 murI Shigella dysenteriae Sd197 glutamate racemase YP_405199.2 3492121 R 300267 CDS YP_405200.1 82778851 3798620 complement(3492923..3494767) 1 NC_007606.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 3494767 btuB 3798620 btuB Shigella dysenteriae Sd197 vitamin B12/cobalamin outer membrane transporter YP_405200.1 3492923 R 300267 CDS YP_405201.1 82778852 3798621 3495136..3496236 1 NC_007606.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 3496236 trmA 3798621 trmA Shigella dysenteriae Sd197 tRNA (uracil-5-)-methyltransferase YP_405201.1 3495136 D 300267 CDS YP_405202.1 82778853 3798622 complement(3496276..3496635) 1 NC_007606.1 hypothetical protein 3496635 yijD 3798622 yijD Shigella dysenteriae Sd197 hypothetical protein YP_405202.1 3496276 R 300267 CDS YP_405203.1 82778854 3798623 complement(3496635..3497339) 1 NC_007606.1 ''negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis''; DNA-binding transcriptional repressor FabR 3497339 yijC 3798623 yijC Shigella dysenteriae Sd197 DNA-binding transcriptional repressor FabR YP_405203.1 3496635 R 300267 CDS YP_405205.1 82778856 3798625 3498300..3498677 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3498677 insB 3798625 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405205.1 3498300 D 300267 CDS YP_405209.1 82778860 3798630 complement(3501678..3502286) 1 NC_007606.1 member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 3502286 yiiX 3798630 yiiX Shigella dysenteriae Sd197 peptidoglycan peptidase YP_405209.1 3501678 R 300267 CDS YP_405210.1 82778861 3798631 complement(3502346..3502663) 1 NC_007606.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor MetJ 3502663 metJ 3798631 metJ Shigella dysenteriae Sd197 transcriptional repressor MetJ YP_405210.1 3502346 R 300267 CDS YP_405211.1 82778862 3798632 3502940..3504100 1 NC_007606.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 3504100 metB 3798632 metB Shigella dysenteriae Sd197 cystathionine gamma-synthase YP_405211.1 3502940 D 300267 CDS YP_405212.1 82778863 3798633 3504103..3506535 1 NC_007606.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 3506535 metL 3798633 metL Shigella dysenteriae Sd197 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_405212.1 3504103 D 300267 CDS YP_405213.1 82778864 3798634 3506884..3507774 1 NC_007606.1 ''MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor''; 5,10-methylenetetrahydrofolate reductase 3507774 metF 3798634 metF Shigella dysenteriae Sd197 5,10-methylenetetrahydrofolate reductase YP_405213.1 3506884 D 300267 CDS YP_405214.1 82778865 3798636 3510276..3511214 1 NC_007606.1 Code: GER; COG: COG0697; hypothetical protein 3511214 yijE 3798636 yijE Shigella dysenteriae Sd197 hypothetical protein YP_405214.1 3510276 D 300267 CDS YP_405215.1 82778866 3798505 complement(3511241..3511858) 1 NC_007606.1 Code: S; COG: COG3738; hypothetical protein 3511858 yijF 3798505 yijF Shigella dysenteriae Sd197 hypothetical protein YP_405215.1 3511241 R 300267 CDS YP_405216.2 161950018 3798506 complement(3512132..3513235) 1 NC_007606.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 3513235 gldA 3798506 gldA Shigella dysenteriae Sd197 glycerol dehydrogenase YP_405216.2 3512132 R 300267 CDS YP_405217.1 82778868 3798507 complement(3513246..3513908) 1 NC_007606.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 3513908 talC 3798507 talC Shigella dysenteriae Sd197 fructose-6-phosphate aldolase YP_405217.1 3513246 R 300267 CDS YP_405218.1 82778869 3798508 complement(3513920..3516055) 1 NC_007606.1 Code: G; COG: COG1080; PTS system transporter subunit I phosphoenolpyruvate-protein kinase /IIA 3516055 ptsA 3798508 ptsA Shigella dysenteriae Sd197 PTS system transporter subunit I phosphoenolpyruvate-protein kinase /IIA YP_405218.1 3513920 R 300267 CDS YP_405220.1 82778871 3798510 3516730..3517809 1 NC_007606.1 ''FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site''; PTS system fructose-like transporter subunit IIC 3517809 frwC 3798510 frwC Shigella dysenteriae Sd197 PTS system fructose-like transporter subunit IIC YP_405220.1 3516730 D 300267 CDS YP_405221.1 82778872 3798511 3517824..3518144 1 NC_007606.1 ''FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS''; PTS system fructose-like transporter subunit IIB 3518144 frwB 3798511 frwB Shigella dysenteriae Sd197 PTS system fructose-like transporter subunit IIB YP_405221.1 3517824 D 300267 CDS YP_405222.1 82778873 3798512 3518195..3520492 1 NC_007606.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 3520492 pflD 3798512 pflD Shigella dysenteriae Sd197 formate acetyltransferase 2 YP_405222.1 3518195 D 300267 CDS YP_405223.1 82778874 3798513 3520458..3521336 1 NC_007606.1 Code: O; COG: COG1180; pyruvate formate lyase II activase 3521336 pflC 3798513 pflC Shigella dysenteriae Sd197 pyruvate formate lyase II activase YP_405223.1 3520458 D 300267 CDS YP_405224.1 82778875 3798514 3521338..3521679 1 NC_007606.1 ''FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog''; PTS system fructose-like transporter subunit IIB 3521679 frwD 3798514 frwD Shigella dysenteriae Sd197 PTS system fructose-like transporter subunit IIB YP_405224.1 3521338 D 300267 CDS YP_405225.1 82778876 3798515 complement(3521666..3522517) 1 NC_007606.1 Code: K; COG: COG2207; AraC family transcriptional regulator 3522517 yijO 3798515 yijO Shigella dysenteriae Sd197 AraC family transcriptional regulator YP_405225.1 3521666 R 300267 CDS YP_405226.1 82778877 3798516 complement(3522666..3524399) 1 NC_007606.1 Code: R; COG: COG2194; hypothetical protein 3524399 yijP 3798516 yijP Shigella dysenteriae Sd197 hypothetical protein YP_405226.1 3522666 R 300267 CDS YP_405227.1 82778878 3798517 complement(3524581..3527232) 1 NC_007606.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 3527232 ppc 3798517 ppc Shigella dysenteriae Sd197 phosphoenolpyruvate carboxylase YP_405227.1 3524581 R 300267 CDS YP_405228.1 82778879 3798518 complement(3527707..3528858) 1 NC_007606.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 3528858 argE 3798518 argE Shigella dysenteriae Sd197 acetylornithine deacetylase YP_405228.1 3527707 R 300267 CDS YP_405229.1 82778880 3798519 3529012..3530016 1 NC_007606.1 ''catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate''; N-acetyl-gamma-glutamyl-phosphate reductase 3530016 argC 3798519 argC Shigella dysenteriae Sd197 N-acetyl-gamma-glutamyl-phosphate reductase YP_405229.1 3529012 D 300267 CDS YP_405230.2 161950017 3798520 3530027..3530800 1 NC_007606.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 3530800 argB 3798520 argB Shigella dysenteriae Sd197 acetylglutamate kinase YP_405230.2 3530027 D 300267 CDS YP_405231.1 82778882 3798521 3530861..3532234 1 NC_007606.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 3532234 argH 3798521 argH Shigella dysenteriae Sd197 argininosuccinate lyase YP_405231.1 3530861 D 300267 CDS YP_405232.1 82778883 3798522 3532501..3533418 1 NC_007606.1 activator of hydrogen peroxide-inducible genes; ''Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA''; DNA-binding transcriptional regulator OxyR 3533418 oxyR 3798522 oxyR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator OxyR YP_405232.1 3532501 D 300267 CDS YP_405233.2 161950016 3798523 complement(3533401..3534801) 1 NC_007606.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 3534801 udhA 3798523 udhA Shigella dysenteriae Sd197 soluble pyridine nucleotide transhydrogenase YP_405233.2 3533401 R 300267 CDS YP_009000839.1 578793315 18263153 3535059..3535331 1 NC_007606.1 insertion element iso-IS1N protein InsA 3535331 18263153 SDY_4767 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000839.1 3535059 D 300267 CDS YP_405235.1 82778886 3799864 3535358..3535753 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3535753 3799864 SDY_3799 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405235.1 3535358 D 300267 CDS YP_405236.1 82778887 3799865 complement(3535728..3539369) 1 NC_007606.1 Code: M; COG: COG3209; rhs element protein RhsB 3539369 rhsB 3799865 rhsB Shigella dysenteriae Sd197 rhs element protein RhsB YP_405236.1 3535728 R 300267 CDS YP_405237.1 82778888 3799866 complement(3539529..3539741) 1 NC_007606.1 ''RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome''; 50S ribosomal protein L31 3539741 rpmE 3799866 rpmE Shigella dysenteriae Sd197 50S ribosomal protein L31 YP_405237.1 3539529 R 300267 CDS YP_405238.1 82778889 3799867 3539944..3542142 1 NC_007606.1 factor Y; helicase; ''binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity''; primosome assembly protein PriA 3542142 priA 3799867 priA Shigella dysenteriae Sd197 primosome assembly protein PriA YP_405238.1 3539944 D 300267 CDS YP_405239.1 82778890 3799868 3542298..3543323 1 NC_007606.1 ''negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins''; DNA-binding transcriptional regulator CytR 3543323 cytR 3799868 cytR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator CytR YP_405239.1 3542298 D 300267 CDS YP_405240.1 82778891 3799869 3543415..3544374 1 NC_007606.1 Code: D; COG: COG3087; cell division protein FtsN 3544374 ftsN 3799869 ftsN Shigella dysenteriae Sd197 cell division protein FtsN YP_405240.1 3543415 D 300267 CDS YP_405241.1 82778892 3799870 3544467..3544997 1 NC_007606.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 3544997 hslV 3799870 hslV Shigella dysenteriae Sd197 ATP-dependent protease peptidase subunit YP_405241.1 3544467 D 300267 CDS YP_405242.1 82778893 3799871 3545007..3546338 1 NC_007606.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 3546338 hslU 3799871 hslU Shigella dysenteriae Sd197 ATP-dependent protease ATP-binding subunit HslU YP_405242.1 3545007 D 300267 CDS YP_405243.1 82778894 3799872 3546405..3547331 1 NC_007606.1 1,4-dihydroxy-2-naphthoate --> dimethylmenaquinone; ''catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate''; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 3547331 menA 3799872 menA Shigella dysenteriae Sd197 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_405243.1 3546405 D 300267 CDS YP_405244.1 82778895 3799873 3547424..3547909 1 NC_007606.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 3547909 menG 3799873 menG Shigella dysenteriae Sd197 ribonuclease activity regulator protein RraA YP_405244.1 3547424 D 300267 CDS YP_405245.1 82778896 3799874 complement(3547966..3548361) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3548361 3799874 SDY_3809 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405245.1 3547966 R 300267 CDS YP_009000840.1 578793316 18263154 complement(3548388..3548660) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3548660 18263154 SDY_4768 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000840.1 3548388 R 300267 CDS YP_405246.1 82778897 3799875 3548759..3549010 1 NC_007606.1 hypothetical protein 3549010 3799875 SDY_3810 Shigella dysenteriae Sd197 hypothetical protein YP_405246.1 3548759 D 300267 CDS YP_405247.1 82778898 3799876 3549146..3549421 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3549421 insA 3799876 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405247.1 3549146 D 300267 CDS YP_405248.1 82778899 3799877 3549466..3549843 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3549843 insB 3799877 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405248.1 3549466 D 300267 CDS YP_405249.1 82778900 3799878 3550322..3550624 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 3550624 3799878 SDY_3813 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_405249.1 3550322 D 300267 CDS YP_405251.1 82778902 3799880 3551506..3551802 1 NC_007606.1 hypothetical protein 3551802 3799880 SDY_3815 Shigella dysenteriae Sd197 hypothetical protein YP_405251.1 3551506 D 300267 CDS YP_405252.1 82778903 3799881 complement(3551841..3552086) 1 NC_007606.1 Code: S; COG: COG3074; hypothetical protein 3552086 yiiU 3799881 yiiU Shigella dysenteriae Sd197 hypothetical protein YP_405252.1 3551841 R 300267 CDS YP_405253.1 82778904 3799882 3552512..3553357 1 NC_007606.1 Code: G; COG: COG0580; facilitated diffusion of glycerol 3553357 glpF 3799882 glpF Shigella dysenteriae Sd197 facilitated diffusion of glycerol YP_405253.1 3552512 D 300267 CDS YP_405254.1 82778905 3799265 3553380..3554888 1 NC_007606.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 3554888 glpK 3799265 glpK Shigella dysenteriae Sd197 glycerol kinase YP_405254.1 3553380 D 300267 CDS YP_405255.1 82778906 3799266 3555118..3556128 1 NC_007606.1 unknown function in glycerol metabolism; ''type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese''; fructose 1,6-bisphosphatase II 3556128 glpX 3799266 glpX Shigella dysenteriae Sd197 fructose 1,6-bisphosphatase II YP_405255.1 3555118 D 300267 CDS YP_405256.1 82778907 3799267 3556225..3556971 1 NC_007606.1 Code: C; COG: COG1018; ferredoxin-NADP reductase 3556971 fpr 3799267 fpr Shigella dysenteriae Sd197 ferredoxin-NADP reductase YP_405256.1 3556225 D 300267 CDS YP_405257.1 82778908 3799268 complement(3556976..3557404) 1 NC_007606.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 3557404 yiiT 3799268 yiiT Shigella dysenteriae Sd197 universal stress protein UspD YP_405257.1 3556976 R 300267 CDS YP_405258.1 82778909 3799269 complement(3557407..3557730) 1 NC_007606.1 Code: S; COG: COG3691; hypothetical protein 3557730 yiiS 3799269 yiiS Shigella dysenteriae Sd197 hypothetical protein YP_405258.1 3557407 R 300267 CDS YP_405259.1 82778910 3799270 complement(3557991..3558386) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3558386 3799270 SDY_3823 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405259.1 3557991 R 300267 CDS YP_009000841.1 578793317 18263155 complement(3558413..3558685) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3558685 18263155 SDY_4769 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000841.1 3558413 R 300267 CDS YP_405260.1 82778911 3799271 complement(3558725..3559156) 1 NC_007606.1 Code: S; COG: COG3152; hypothetical protein 3559156 yiiR 3799271 yiiR Shigella dysenteriae Sd197 hypothetical protein YP_405260.1 3558725 R 300267 CDS YP_405261.1 82778912 3799272 3559257..3559856 1 NC_007606.1 hypothetical protein 3559856 yiiQ 3799272 yiiQ Shigella dysenteriae Sd197 hypothetical protein YP_405261.1 3559257 D 300267 CDS YP_405262.1 82778913 3799273 3559964..3560731 1 NC_007606.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 3560731 tpiA 3799273 tpiA Shigella dysenteriae Sd197 triosephosphate isomerase YP_405262.1 3559964 D 300267 CDS YP_405263.1 82778914 3799274 complement(3561298..3561675) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3561675 insB 3799274 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405263.1 3561298 R 300267 CDS YP_405264.1 82778915 3799275 complement(3561720..3561995) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3561995 insA 3799275 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405264.1 3561720 R 300267 CDS YP_405265.1 82778916 3799277 complement(3562425..3563414) 1 NC_007606.1 Code: P; COG: COG1613; sulfate transporter subunit 3563414 sbp 3799277 sbp Shigella dysenteriae Sd197 sulfate transporter subunit YP_405265.1 3562425 R 300267 CDS YP_405266.1 82778917 3799278 complement(3563733..3564695) 1 NC_007606.1 ''catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis''; 6-phosphofructokinase 3564695 pfkA 3799278 pfkA Shigella dysenteriae Sd197 6-phosphofructokinase YP_405266.1 3563733 R 300267 CDS YP_405267.1 82778918 3799279 complement(3564876..3565778) 1 NC_007606.1 ''member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers''; ferrous iron efflux protein F 3565778 fieF 3799279 fieF Shigella dysenteriae Sd197 ferrous iron efflux protein F YP_405267.1 3564876 R 300267 CDS YP_405268.2 161950015 3799280 complement(3565926..3566426) 1 NC_007606.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 3566426 cpxP 3799280 cpxP Shigella dysenteriae Sd197 repressor CpxP YP_405268.2 3565926 R 300267 CDS YP_405269.1 82778920 3799281 3566576..3567274 1 NC_007606.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 3567274 cpxR 3799281 cpxR Shigella dysenteriae Sd197 DNA-binding transcriptional regulator CpxR YP_405269.1 3566576 D 300267 CDS YP_405270.1 82778921 3799282 3567271..3568644 1 NC_007606.1 probable sensor protein; acting on arcA; part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 3568644 cpxA 3799282 cpxA Shigella dysenteriae Sd197 two-component sensor protein YP_405270.1 3567271 D 300267 CDS YP_405271.2 161950014 3799283 complement(3568712..3569386) 1 NC_007606.1 Code: S; COG: COG2258; hypothetical protein 3569386 yiiM 3799283 yiiM Shigella dysenteriae Sd197 hypothetical protein YP_405271.2 3568712 R 300267 CDS YP_405272.2 161950013 3798466 complement(3569535..3570521) 1 NC_007606.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 3570521 kdgT 3798466 kdgT Shigella dysenteriae Sd197 2-keto-3-deoxygluconate permease YP_405272.2 3569535 R 300267 CDS YP_405273.1 82778924 3798467 complement(3570781..3571401) 1 NC_007606.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 3571401 sodA 3798467 sodA Shigella dysenteriae Sd197 superoxide dismutase YP_405273.1 3570781 R 300267 CDS YP_405274.1 82778925 3798468 3571686..3572720 1 NC_007606.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 3572720 rhaT 3798468 rhaT Shigella dysenteriae Sd197 rhamnose-proton symporter YP_405274.1 3571686 D 300267 CDS YP_405275.1 82778926 3798469 complement(3572717..3573655) 1 NC_007606.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 3573655 rhaR 3798469 rhaR Shigella dysenteriae Sd197 transcriptional activator RhaR YP_405275.1 3572717 R 300267 CDS YP_405276.1 82778927 3798470 complement(3573639..3574475) 1 NC_007606.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 3574475 rhaS 3798470 rhaS Shigella dysenteriae Sd197 transcriptional activator RhaS YP_405276.1 3573639 R 300267 CDS YP_405277.1 82778928 3798471 3574763..3575926 1 NC_007606.1 Code: G; COG: COG1070; rhamnulokinase 3575926 rhaB 3798471 rhaB Shigella dysenteriae Sd197 rhamnulokinase YP_405277.1 3574763 D 300267 CDS YP_405278.1 82778929 3798473 3577181..3578005 1 NC_007606.1 Code: G; COG: COG0235; rhamnulose-1-phosphate aldolase 3578005 rhaD 3798473 rhaD Shigella dysenteriae Sd197 rhamnulose-1-phosphate aldolase YP_405278.1 3577181 D 300267 CDS YP_405279.1 82778930 3798474 3578015..3578329 1 NC_007606.1 Code: S; COG: COG3254; hypothetical protein 3578329 yiiL 3798474 yiiL Shigella dysenteriae Sd197 hypothetical protein YP_405279.1 3578015 D 300267 CDS YP_009000842.1 578793318 18263156 complement(3579074..3579346) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3579346 18263156 SDY_4770 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000842.1 3579074 R 300267 CDS YP_405281.1 82778932 3798477 complement(3580174..3581007) 1 NC_007606.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 3581007 fdhD 3798477 fdhD Shigella dysenteriae Sd197 formate dehydrogenase accessory protein YP_405281.1 3580174 R 300267 CDS YP_405282.1 82778933 3798478 3581201..3584251 1 NC_007606.1 Code: C; COG: COG0243; formate dehydrogenase-O, major subunit 3584251 fdoG 3798478 fdoG Shigella dysenteriae Sd197 formate dehydrogenase-O, major subunit YP_405282.1 3581201 D 300267 CDS YP_405283.1 82778934 3798479 3584264..3585166 1 NC_007606.1 Code: C; COG: COG0437; formate dehydrogenase-O, iron-sulfur subunit 3585166 fdoH 3798479 fdoH Shigella dysenteriae Sd197 formate dehydrogenase-O, iron-sulfur subunit YP_405283.1 3584264 D 300267 CDS YP_405284.1 82778935 3798480 3585163..3585798 1 NC_007606.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 3585798 fdoI 3798480 fdoI Shigella dysenteriae Sd197 formate dehydrogenase-O subunit gamma YP_405284.1 3585163 D 300267 CDS YP_405285.1 82778936 3798481 3585795..3586724 1 NC_007606.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 3586724 fdhE 3798481 fdhE Shigella dysenteriae Sd197 formate dehydrogenase accessory protein FdhE YP_405285.1 3585795 D 300267 CDS YP_405286.1 82778937 3798482 complement(3587044..3587421) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3587421 insB 3798482 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405286.1 3587044 R 300267 CDS YP_405287.1 82778938 3798483 complement(3587466..3587741) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3587741 insA 3798483 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405287.1 3587466 R 300267 CDS YP_405288.1 82778939 3798484 complement(3587919..3588908) 1 NC_007606.1 Code: KR; COG: COG0454; acetyltransferase 3588908 yiiD 3798484 yiiD Shigella dysenteriae Sd197 acetyltransferase YP_405288.1 3587919 R 300267 CDS YP_405289.1 82778940 3798485 complement(3588905..3589342) 1 NC_007606.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 3589342 yihZ 3798485 yihZ Shigella dysenteriae Sd197 D-tyrosyl-tRNA(Tyr) deacylase YP_405289.1 3588905 R 300267 CDS YP_405290.1 82778941 3797237 complement(3589339..3590211) 1 NC_007606.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 3590211 rbn 3797237 rbn Shigella dysenteriae Sd197 ribonuclease BN YP_405290.1 3589339 R 300267 CDS YP_405291.2 161950012 3797238 complement(3590205..3590804) 1 NC_007606.1 Code: R; COG: COG1011; phosphatase 3590804 yihX 3797238 yihX Shigella dysenteriae Sd197 phosphatase YP_405291.2 3590205 R 300267 CDS YP_405295.1 82778946 3797242 complement(3593155..3593457) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 3593457 3797242 SDY_3862 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_405295.1 3593155 R 300267 CDS YP_405296.1 82778947 3797243 complement(3593621..3594352) 1 NC_007606.1 hypothetical protein 3594352 3797243 SDY_3863 Shigella dysenteriae Sd197 hypothetical protein YP_405296.1 3593621 R 300267 CDS YP_009000843.1 578793319 18263157 3594623..3594895 1 NC_007606.1 insertion element iso-IS1N protein InsA 3594895 18263157 SDY_4771 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000843.1 3594623 D 300267 CDS YP_405300.1 82778951 3797247 complement(3595326..3596030) 1 NC_007606.1 Code: GEPR; COG: COG0477; shikimate transporter 3596030 3797247 SDY_3867 Shigella dysenteriae Sd197 shikimate transporter YP_405300.1 3595326 R 300267 CDS YP_405301.1 82778952 3797248 3596178..3596453 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3596453 insA 3797248 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405301.1 3596178 D 300267 CDS YP_405302.1 82778953 3797249 3596498..3596875 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3596875 insB 3797249 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405302.1 3596498 D 300267 CDS YP_405303.1 82778954 3797251 complement(3597568..3598914) 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 3598914 3797251 SDY_3871 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_405303.1 3597568 R 300267 CDS YP_405304.1 82778955 3797252 complement(3599019..3600842) 1 NC_007606.1 Code: T; COG: COG1217; GTP-binding protein 3600842 yihK 3797252 yihK Shigella dysenteriae Sd197 GTP-binding protein YP_405304.1 3599019 R 300267 CDS YP_405305.1 82778956 3797253 3601215..3602624 1 NC_007606.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 3602624 glnA 3797253 glnA Shigella dysenteriae Sd197 glutamine synthetase YP_405305.1 3601215 D 300267 CDS YP_405306.1 82778957 3797254 3602798..3603847 1 NC_007606.1 nitrogen regulator II, NRII; sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 3603847 glnL 3797254 glnL Shigella dysenteriae Sd197 nitrogen regulation protein NR(II) YP_405306.1 3602798 D 300267 CDS YP_405307.1 82778958 3797255 3603859..3605268 1 NC_007606.1 sensor glnL; nitrogen regulator I, NRI; response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 3605268 glnG 3797255 glnG Shigella dysenteriae Sd197 nitrogen regulation protein NR(I) YP_405307.1 3603859 D 300267 CDS YP_405308.2 161950011 3796992 complement(3605680..3607053) 1 NC_007606.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3607053 hemN 3796992 hemN Shigella dysenteriae Sd197 coproporphyrinogen III oxidase YP_405308.2 3605680 R 300267 CDS YP_405309.1 82778960 3796993 complement(3607242..3607748) 1 NC_007606.1 Code: S; COG: COG3078; hypothetical protein 3607748 yihI 3796993 yihI Shigella dysenteriae Sd197 hypothetical protein YP_405309.1 3607242 R 300267 CDS YP_405310.2 161950010 3796994 3608330..3608962 1 NC_007606.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3608962 engB 3796994 engB Shigella dysenteriae Sd197 ribosome biogenesis GTP-binding protein YsxC YP_405310.2 3608330 D 300267 CDS YP_405311.1 82778962 3796995 complement(3609343..3612129) 1 NC_007606.1 DNA polymerase I, 3' --> 5' polymerase, 5' --> 3' and 3' --> 5' exonuclease; ''has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair''; DNA polymerase I 3612129 polA 3796995 polA Shigella dysenteriae Sd197 DNA polymerase I YP_405311.1 3609343 R 300267 CDS YP_405312.1 82778963 3796996 3612493..3613425 1 NC_007606.1 Code: I; COG: COG0204; acyltransferase 3613425 yihG 3796996 yihG Shigella dysenteriae Sd197 acyltransferase YP_405312.1 3612493 D 300267 CDS YP_405313.1 82778964 3796997 complement(3614226..3614441) 1 NC_007606.1 insertion element iso-IS1n protein InsB 3614441 3796997 SDY_3881 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405313.1 3614226 R 300267 CDS YP_009000844.1 578793320 18263158 complement(3614647..3614919) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3614919 18263158 SDY_4772 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000844.1 3614647 R 300267 CDS YP_405314.1 82778965 3796999 complement(3615684..3616061) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3616061 insB 3796999 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405314.1 3615684 R 300267 CDS YP_405315.1 82778966 3797000 complement(3616106..3616381) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3616381 insA 3797000 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405315.1 3616106 R 300267 CDS YP_405316.1 82778967 3797001 complement(3616601..3617227) 1 NC_007606.1 essential for cytochrome c synthesis and formate-dependent reduction; Code: OC; COG: COG0526; protein disulfide isomerase 3617227 dsbA 3797001 dsbA Shigella dysenteriae Sd197 protein disulfide isomerase YP_405316.1 3616601 R 300267 CDS YP_405317.1 82778968 3797002 complement(3617244..3618230) 1 NC_007606.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 3618230 yihE 3797002 yihE Shigella dysenteriae Sd197 serine/threonine protein kinase YP_405317.1 3617244 R 300267 CDS YP_405318.1 82778969 3797003 complement(3618307..3618576) 1 NC_007606.1 Code: S; COG: COG3084; hypothetical protein 3618576 yihD 3797003 yihD Shigella dysenteriae Sd197 hypothetical protein YP_405318.1 3618307 R 300267 CDS YP_405319.1 82778970 3797004 3618646..3619230 1 NC_007606.1 molybdopterin ---> molybdopterin-guanine dinucleotide, protein Ar; Links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 3619230 mobA 3797004 mobA Shigella dysenteriae Sd197 molybdopterin-guanine dinucleotide biosynthesis protein A YP_405319.1 3618646 D 300267 CDS YP_405320.1 82778971 3797005 3619227..3619739 1 NC_007606.1 Code: H; COG: COG1763; molybdopterin-guanine dinucleotide biosynthesis protein B 3619739 mobB 3797005 mobB Shigella dysenteriae Sd197 molybdopterin-guanine dinucleotide biosynthesis protein B YP_405320.1 3619227 D 300267 CDS YP_405321.1 82778972 3797011 complement(3625309..3625854) 1 NC_007606.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 3625854 hemG 3797011 hemG Shigella dysenteriae Sd197 protoporphyrinogen oxidase YP_405321.1 3625309 R 300267 CDS YP_405322.1 82778973 3797012 complement(3625866..3627317) 1 NC_007606.1 requires TrkE; Code: P; COG: COG0168; potassium transporter 3627317 trkH 3797012 trkH Shigella dysenteriae Sd197 potassium transporter YP_405322.1 3625866 R 300267 CDS YP_405323.1 82778974 3797013 complement(3627356..3627973) 1 NC_007606.1 Code: S; COG: COG1739; hypothetical protein 3627973 yigZ 3797013 yigZ Shigella dysenteriae Sd197 hypothetical protein YP_405323.1 3627356 R 300267 CDS YP_405324.1 82778975 3797014 complement(3627970..3629301) 1 NC_007606.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 3629301 pepQ 3797014 pepQ Shigella dysenteriae Sd197 proline dipeptidase YP_405324.1 3627970 R 300267 CDS YP_405325.1 82778976 3797015 3629491..3631680 1 NC_007606.1 4-enzyme protein; ''includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids''; multifunctional fatty acid oxidation complex subunit alpha 3631680 fadB 3797015 fadB Shigella dysenteriae Sd197 multifunctional fatty acid oxidation complex subunit alpha YP_405325.1 3629491 D 300267 CDS YP_405326.1 82778977 3797016 3631690..3632853 1 NC_007606.1 3-ketoacyl-CoA thiolase; acetyl-CoA transferase; FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 3632853 fadA 3797016 fadA Shigella dysenteriae Sd197 3-ketoacyl-CoA thiolase YP_405326.1 3631690 D 300267 CDS YP_405327.1 82778978 3797017 complement(3633046..3633747) 1 NC_007606.1 flavin reductase; NADPH:flavin oxidoreductase; NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 3633747 fre 3797017 fre Shigella dysenteriae Sd197 FMN reductase YP_405327.1 3633046 R 300267 CDS YP_405328.1 82778979 3797018 complement(3633793..3635286) 1 NC_007606.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 3635286 yigC 3797018 yigC Shigella dysenteriae Sd197 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_405328.1 3633793 R 300267 CDS YP_405329.1 82778980 3797019 3635453..3635941 1 NC_007606.1 Code: K; COG: COG0250; transcriptional activator RfaH 3635941 rfaH 3797019 rfaH Shigella dysenteriae Sd197 transcriptional activator RfaH YP_405329.1 3635453 D 300267 CDS YP_405330.1 82778981 3797021 complement(3636761..3637537) 1 NC_007606.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 3637537 yigU 3797021 yigU Shigella dysenteriae Sd197 twin-arginine protein translocation system subunit TatC YP_405330.1 3636761 R 300267 CDS YP_405331.2 161950009 3797022 complement(3637540..3638055) 1 NC_007606.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 3638055 3797022 SDY_3906 Shigella dysenteriae Sd197 sec-independent translocase YP_405331.2 3637540 R 300267 CDS YP_405332.1 82778983 3797023 complement(3638059..3638370) 1 NC_007606.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 3638370 tatA 3797023 tatA Shigella dysenteriae Sd197 twin-arginine translocation protein TatA YP_405332.1 3638059 R 300267 CDS YP_405333.1 82778984 3797024 complement(3638407..3640047) 1 NC_007606.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 3640047 ubiB 3797024 ubiB Shigella dysenteriae Sd197 ubiquinone biosynthesis protein UbiB YP_405333.1 3638407 R 300267 CDS YP_405334.1 82778985 3797025 complement(3640044..3640649) 1 NC_007606.1 Code: S; COG: COG3165; hypothetical protein 3640649 yigP 3797025 yigP Shigella dysenteriae Sd197 hypothetical protein YP_405334.1 3640044 R 300267 CDS YP_405335.1 82778986 3796597 complement(3640663..3641418) 1 NC_007606.1 2-octaprenyl-6-methoxy-1,4-benzoquinone --> 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone; Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 3641418 ubiE 3796597 ubiE Shigella dysenteriae Sd197 ubiquinone/menaquinone biosynthesis methyltransferase YP_405335.1 3640663 R 300267 CDS YP_405336.1 82778987 3796598 complement(3641513..3642940) 1 NC_007606.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 3642940 yigN 3796598 yigN Shigella dysenteriae Sd197 DNA recombination protein RmuC YP_405336.1 3641513 R 300267 CDS YP_405337.1 82778988 3796599 complement(3643081..3643842) 1 NC_007606.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 3643842 udp 3796599 udp Shigella dysenteriae Sd197 uridine phosphorylase YP_405337.1 3643081 R 300267 CDS YP_405338.1 82778989 3796600 3644050..3644919 1 NC_007606.1 Code: Q; COG: COG0412; dienelactone hydrolase 3644919 3796600 SDY_3913 Shigella dysenteriae Sd197 dienelactone hydrolase YP_405338.1 3644050 D 300267 CDS YP_405339.1 82778990 3796601 complement(3644959..3647220) 1 NC_007606.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 3647220 metE 3796601 metE Shigella dysenteriae Sd197 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_405339.1 3644959 R 300267 CDS YP_405340.1 82778991 3796602 3647456..3648409 1 NC_007606.1 Code: K; COG: COG0583; metE and metH regulator 3648409 metR 3796602 metR Shigella dysenteriae Sd197 metE and metH regulator YP_405340.1 3647456 D 300267 CDS YP_405341.1 82778992 3796603 complement(3648297..3649196) 1 NC_007606.1 Code: GER; COG: COG0697; hypothetical protein 3649196 yigM 3796603 yigM Shigella dysenteriae Sd197 hypothetical protein YP_405341.1 3648297 R 300267 CDS YP_405342.1 82778993 3796604 complement(3649272..3650072) 1 NC_007606.1 ''purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium''; sugar phosphatase 3650072 3796604 SDY_3917 Shigella dysenteriae Sd197 sugar phosphatase YP_405342.1 3649272 R 300267 CDS YP_405343.1 82778994 3796605 complement(3650080..3651102) 1 NC_007606.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 3651102 pldB 3796605 pldB Shigella dysenteriae Sd197 lysophospholipase L2 YP_405343.1 3650080 R 300267 CDS YP_405344.2 578793321 3796606 3651213..3651833 1 NC_007606.1 Code: E; COG: COG1280; hypothetical protein 3651833 yigK 3796606 yigK Shigella dysenteriae Sd197 hypothetical protein YP_405344.2 3651213 D 300267 CDS YP_405345.2 578793322 3796607 complement(3651895..3652515) 1 NC_007606.1 Code: E; COG: COG1280; hypothetical protein 3652515 yigJ 3796607 yigJ Shigella dysenteriae Sd197 hypothetical protein YP_405345.2 3651895 R 300267 CDS YP_405346.1 82778997 3796608 complement(3652579..3654414) 1 NC_007606.1 ''functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway''; ATP-dependent DNA helicase RecQ 3654414 recQ 3796608 recQ Shigella dysenteriae Sd197 ATP-dependent DNA helicase RecQ YP_405346.1 3652579 R 300267 CDS YP_405347.1 82778998 3796609 complement(3654541..3655410) 1 NC_007606.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 3655410 pldA 3796609 pldA Shigella dysenteriae Sd197 phospholipase A YP_405347.1 3654541 R 300267 CDS YP_405348.2 161950008 3796610 3655575..3656042 1 NC_007606.1 Code: Q; COG: COG2050; hypothetical protein 3656042 yigI 3796610 yigI Shigella dysenteriae Sd197 hypothetical protein YP_405348.2 3655575 D 300267 CDS YP_405349.1 82779000 3796611 3656094..3656987 1 NC_007606.1 Code: R; COG: COG2962; hypothetical protein 3656987 rarD 3796611 rarD Shigella dysenteriae Sd197 hypothetical protein YP_405349.1 3656094 D 300267 CDS YP_405350.1 82779001 3796612 3657107..3657382 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3657382 insA 3796612 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405350.1 3657107 D 300267 CDS YP_405351.1 82779002 3796613 3657427..3657804 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3657804 insB 3796613 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405351.1 3657427 D 300267 CDS YP_405352.1 82779003 3796614 complement(3658262..3658639) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3658639 insB 3796614 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405352.1 3658262 R 300267 CDS YP_405353.1 82779004 3796615 complement(3658684..3658959) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3658959 insA 3796615 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405353.1 3658684 R 300267 CDS YP_405354.1 82779005 3796616 complement(3659193..3660143) 1 NC_007606.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 3660143 corA 3796616 corA Shigella dysenteriae Sd197 magnesium/nickel/cobalt transporter CorA YP_405354.1 3659193 R 300267 CDS YP_405355.1 82779006 3797768 3660513..3661277 1 NC_007606.1 Code: S; COG: COG3698; hypothetical protein 3661277 yigE 3797768 yigE Shigella dysenteriae Sd197 hypothetical protein YP_405355.1 3660513 D 300267 CDS YP_405356.1 82779007 3797769 3661360..3662262 1 NC_007606.1 Code: S; COG: COG1912; hypothetical protein 3662262 3797769 SDY_3931 Shigella dysenteriae Sd197 hypothetical protein YP_405356.1 3661360 D 300267 CDS YP_405357.1 82779008 3797770 complement(3662317..3664479) 1 NC_007606.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 3664479 uvrD 3797770 uvrD Shigella dysenteriae Sd197 DNA-dependent helicase II YP_405357.1 3662317 R 300267 CDS YP_405358.1 82779009 3797771 complement(3664563..3665279) 1 NC_007606.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 3665279 yigB 3797771 yigB Shigella dysenteriae Sd197 flavin mononucleotide phosphatase YP_405358.1 3664563 R 300267 CDS YP_405359.1 82779010 3797772 complement(3665279..3666175) 1 NC_007606.1 acts on cer sequence of ColE1; effects chromosome segregation at cell division; site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 3666175 xerC 3797772 xerC Shigella dysenteriae Sd197 site-specific tyrosine recombinase XerC YP_405359.1 3665279 R 300267 CDS YP_405360.1 82779011 3797773 complement(3666172..3666879) 1 NC_007606.1 Code: S; COG: COG3159; hypothetical protein 3666879 yigA 3797773 yigA Shigella dysenteriae Sd197 hypothetical protein YP_405360.1 3666172 R 300267 CDS YP_405361.2 161950007 3797774 complement(3666876..3667700) 1 NC_007606.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3667700 dapF 3797774 dapF Shigella dysenteriae Sd197 diaminopimelate epimerase YP_405361.2 3666876 R 300267 CDS YP_405362.1 82779013 3797775 complement(3667737..3667940) 1 NC_007606.1 Code: N; COG: COG5567; hypothetical protein 3667940 yifL 3797775 yifL Shigella dysenteriae Sd197 hypothetical protein YP_405362.1 3667737 R 300267 CDS YP_405363.1 82779015 3797777 complement(3668127..3668612) 1 NC_007606.1 hypothetical protein 3668612 3797777 SDY_3939 Shigella dysenteriae Sd197 hypothetical protein YP_405363.1 3668127 R 300267 CDS YP_405364.1 82779014 3797776 3668403..3668723 1 NC_007606.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3668723 cyaY 3797776 cyaY Shigella dysenteriae Sd197 frataxin-like protein YP_405364.1 3668403 D 300267 CDS YP_405365.1 82779016 3797778 complement(3668763..3671309) 1 NC_007606.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 3671309 cyaA 3797778 cyaA Shigella dysenteriae Sd197 adenylate cyclase YP_405365.1 3668763 R 300267 CDS YP_405366.1 82779017 3797779 3671675..3672637 1 NC_007606.1 hydroxymethylbilane synthase; transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3672637 hemC 3797779 hemC Shigella dysenteriae Sd197 porphobilinogen deaminase YP_405366.1 3671675 D 300267 CDS YP_405367.1 82779018 3797780 3672634..3673374 1 NC_007606.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3673374 hemD 3797780 hemD Shigella dysenteriae Sd197 uroporphyrinogen-III synthase YP_405367.1 3672634 D 300267 CDS YP_405368.1 82779019 3797781 3673396..3674577 1 NC_007606.1 Code: H; COG: COG2959; uroporphyrinogen III C-methyltransferase 3674577 hemX 3797781 hemX Shigella dysenteriae Sd197 uroporphyrinogen III C-methyltransferase YP_405368.1 3673396 D 300267 CDS YP_405369.1 82779020 3797782 3674580..3675776 1 NC_007606.1 Code: H; COG: COG3071; protoheme IX biogenesis protein 3675776 hemY 3797782 hemY Shigella dysenteriae Sd197 protoheme IX biogenesis protein YP_405369.1 3674580 D 300267 CDS YP_405370.1 82779021 3797783 3676454..3678109 1 NC_007606.1 Code: P; COG: COG3119; arylsulfatase 3678109 aslA 3797783 aslA Shigella dysenteriae Sd197 arylsulfatase YP_405370.1 3676454 D 300267 CDS YP_009000845.1 578793323 18263159 3679015..3679287 1 NC_007606.1 insertion element iso-IS1N protein InsA 3679287 18263159 SDY_4773 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000845.1 3679015 D 300267 CDS YP_405371.1 82779022 3797784 3679314..3679709 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3679709 3797784 SDY_3946 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405371.1 3679314 D 300267 CDS YP_405372.1 82779023 3797449 complement(3680972..3682357) 1 NC_007606.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transport protein YifK 3682357 yifK 3797449 yifK Shigella dysenteriae Sd197 transport protein YifK YP_405372.1 3680972 R 300267 CDS YP_405373.1 82779024 3797450 complement(3682548..3683288) 1 NC_007606.1 synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG1922; UDP-N-acetyl-D-mannosaminuronic acid transferase 3683288 wecG 3797450 wecG Shigella dysenteriae Sd197 UDP-N-acetyl-D-mannosaminuronic acid transferase YP_405373.1 3682548 R 300267 CDS YP_405374.1 82779025 3797451 complement(3683291..3684643) 1 NC_007606.1 synthesis of enterobacterial common antigen (ECA); enterobacterial common antigen polymerase; common antigen polymerase 3684643 wecF 3797451 wecF Shigella dysenteriae Sd197 common antigen polymerase YP_405374.1 3683291 R 300267 CDS YP_405375.1 82779026 3797452 complement(3684640..3685719) 1 NC_007606.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 3685719 yifM 3797452 yifM Shigella dysenteriae Sd197 4-alpha-L-fucosyltransferase YP_405375.1 3684640 R 300267 CDS YP_405376.1 82779027 3797453 complement(3685716..3686966) 1 NC_007606.1 Code: R; COG: COG2244; cytochrome 3686966 wzxE 3797453 wzxE Shigella dysenteriae Sd197 cytochrome YP_405376.1 3685716 R 300267 CDS YP_405377.1 82779028 3797454 complement(3686968..3688098) 1 NC_007606.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 3688098 wecE 3797454 wecE Shigella dysenteriae Sd197 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_405377.1 3686968 R 300267 CDS YP_405378.1 82779029 3797455 complement(3688103..3688648) 1 NC_007606.1 Code: KR; COG: COG0454; TDP-fucosamine acetyltransferase 3688648 wecD 3797455 wecD Shigella dysenteriae Sd197 TDP-fucosamine acetyltransferase YP_405378.1 3688103 R 300267 CDS YP_405379.1 82779030 3797456 complement(3688755..3689636) 1 NC_007606.1 Code: M; COG: COG1209; glucose-1-phosphate thymidylyltransferase 3689636 rffH 3797456 rffH Shigella dysenteriae Sd197 glucose-1-phosphate thymidylyltransferase YP_405379.1 3688755 R 300267 CDS YP_405380.1 82779031 3797458 complement(3690630..3691892) 1 NC_007606.1 synthesis of enterobacterial common antigen (ECA); catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 3691892 wecC 3797458 wecC Shigella dysenteriae Sd197 UDP-N-acetyl-D-mannosamine dehydrogenase YP_405380.1 3690630 R 300267 CDS YP_405381.1 82779032 3797459 complement(3691889..3693061) 1 NC_007606.1 synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0381; UDP-N-acetyl glucosamine -2-epimerase 3693061 wecB 3797459 wecB Shigella dysenteriae Sd197 UDP-N-acetyl glucosamine -2-epimerase YP_405381.1 3691889 R 300267 CDS YP_405382.1 82779033 3797460 complement(3693075..3694124) 1 NC_007606.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 3694124 wzzE 3797460 wzzE Shigella dysenteriae Sd197 lipopolysaccharide biosynthesis protein WzzE YP_405382.1 3693075 R 300267 CDS YP_405383.1 82779034 3797709 complement(3694133..3695236) 1 NC_007606.1 synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0472; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 3695236 rfe 3797709 rfe Shigella dysenteriae Sd197 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_405383.1 3694133 R 300267 CDS YP_405384.1 82779035 3797710 complement(3695248..3695466) 1 NC_007606.1 hypothetical protein 3695466 3797710 SDY_3965 Shigella dysenteriae Sd197 hypothetical protein YP_405384.1 3695248 R 300267 CDS YP_405385.1 82779036 3797711 complement(3695476..3696735) 1 NC_007606.1 polarity suppressor; An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 3696735 rho 3797711 rho Shigella dysenteriae Sd197 transcription termination factor Rho YP_405385.1 3695476 R 300267 CDS YP_405386.1 82779037 3797712 complement(3696820..3696921) 1 NC_007606.1 rho operon leader peptide 3696921 rhoL 3797712 rhoL Shigella dysenteriae Sd197 rho operon leader peptide YP_405386.1 3696820 R 300267 CDS YP_405387.1 82779038 3797713 complement(3697062..3697445) 1 NC_007606.1 Code: OC; COG: COG0526; thioredoxin 3697445 trxA 3797713 trxA Shigella dysenteriae Sd197 thioredoxin YP_405387.1 3697062 R 300267 CDS YP_405388.1 82779039 3797714 3697522..3698787 1 NC_007606.1 ''enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation''; ATP-dependent RNA helicase RhlB 3698787 rhlB 3797714 rhlB Shigella dysenteriae Sd197 ATP-dependent RNA helicase RhlB YP_405388.1 3697522 D 300267 CDS YP_405389.1 82779040 3797715 3698921..3700405 1 NC_007606.1 exopolyphosphatase; ''catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation''; guanosine pentaphosphate phosphohydrolase 3700405 gppA 3797715 gppA Shigella dysenteriae Sd197 guanosine pentaphosphate phosphohydrolase YP_405389.1 3698921 D 300267 CDS YP_405390.1 82779041 3797716 complement(3700452..3702473) 1 NC_007606.1 a single-stranded DNA dependent ATPase; single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 3702473 rep 3797716 rep Shigella dysenteriae Sd197 ATP-dependent DNA helicase Rep YP_405390.1 3700452 R 300267 CDS YP_405391.2 161950006 3797717 3703253..3704158 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3704158 3797717 SDY_3972 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405391.2 3703253 D 300267 CDS YP_009000846.1 578793324 18263160 3704165..3704476 1 NC_007606.1 hypothetical protein 3704476 18263160 SDY_3972a Shigella dysenteriae Sd197 hypothetical protein YP_009000846.1 3704165 D 300267 CDS YP_405392.1 82779043 3797718 3704675..3704956 1 NC_007606.1 rotamase C; Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase C 3704956 ppiC 3797718 ppiC Shigella dysenteriae Sd197 peptidyl-prolyl cis-trans isomerase C YP_405392.1 3704675 D 300267 CDS YP_405393.1 82779044 3797719 complement(3705002..3706477) 1 NC_007606.1 ''catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis''; ketol-acid reductoisomerase 3706477 ilvC 3797719 ilvC Shigella dysenteriae Sd197 ketol-acid reductoisomerase YP_405393.1 3705002 R 300267 CDS YP_405394.2 161950005 3797720 3706627..3707517 1 NC_007606.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3707517 ilvY 3797720 ilvY Shigella dysenteriae Sd197 DNA-binding transcriptional regulator IlvY YP_405394.2 3706627 D 300267 CDS YP_405395.1 82779046 3797721 complement(3707514..3709058) 1 NC_007606.1 dehydratase; ''threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway''; threonine dehydratase 3709058 ilvA 3797721 ilvA Shigella dysenteriae Sd197 threonine dehydratase YP_405395.1 3707514 R 300267 CDS YP_405396.1 82779047 3797722 complement(3709061..3710911) 1 NC_007606.1 ''catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis''; dihydroxy-acid dehydratase 3710911 ilvD 3797722 ilvD Shigella dysenteriae Sd197 dihydroxy-acid dehydratase YP_405396.1 3709061 R 300267 CDS YP_405397.1 82779048 3797723 complement(3710976..3711905) 1 NC_007606.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3711905 ilvE 3797723 ilvE Shigella dysenteriae Sd197 branched-chain amino acid aminotransferase YP_405397.1 3710976 R 300267 CDS YP_405398.1 82779049 3797724 complement(3711925..3712188) 1 NC_007606.1 Code: S; COG: COG3978; acetolactate synthase 2 regulatory subunit 3712188 ilvM 3797724 ilvM Shigella dysenteriae Sd197 acetolactate synthase 2 regulatory subunit YP_405398.1 3711925 R 300267 CDS YP_405399.1 82779050 3797725 complement(3712185..3713831) 1 NC_007606.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 3713831 ilvG 3797725 ilvG Shigella dysenteriae Sd197 acetolactate synthase 2 catalytic subunit YP_405399.1 3712185 R 300267 CDS YP_405400.1 82779051 3797726 complement(3713971..3714069) 1 NC_007606.1 ilvG operon leader peptide 3714069 ilvL 3797726 ilvL Shigella dysenteriae Sd197 ilvG operon leader peptide YP_405400.1 3713971 R 300267 CDS YP_405401.1 82779052 3797728 3715802..3716998 1 NC_007606.1 Code: L; COG: COG3547; insertion element IS110 transposase 3716998 3797728 SDY_3983 Shigella dysenteriae Sd197 insertion element IS110 transposase YP_405401.1 3715802 D 300267 CDS YP_405402.1 82779053 3798008 complement(3717404..3717742) 1 NC_007606.1 Code: S; COG: COG3085; hypothetical protein 3717742 yifE 3798008 yifE Shigella dysenteriae Sd197 hypothetical protein YP_405402.1 3717404 R 300267 CDS YP_405403.1 82779054 3798009 3717861..3718700 1 NC_007606.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3718700 yifDA 3798009 yifDA Shigella dysenteriae Sd197 transcriptional regulator HdfR YP_405403.1 3717861 D 300267 CDS YP_405404.1 82779055 3798016 3724491..3725183 1 NC_007606.1 Code: K; COG: COG2186; hypothetical protein 3725183 yieP 3798016 yieP Shigella dysenteriae Sd197 hypothetical protein YP_405404.1 3724491 D 300267 CDS YP_405405.1 82779056 3798017 3725206..3726633 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 3726633 yieO 3798017 yieO Shigella dysenteriae Sd197 transport protein YP_405405.1 3725206 D 300267 CDS YP_405406.1 82779057 3798018 complement(3726641..3727591) 1 NC_007606.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 3727591 rbsR 3798018 rbsR Shigella dysenteriae Sd197 transcriptional repressor RbsR YP_405406.1 3726641 R 300267 CDS YP_405407.1 82779058 3798019 complement(3727595..3728524) 1 NC_007606.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 3728524 rbsK 3798019 rbsK Shigella dysenteriae Sd197 ribokinase YP_405407.1 3727595 R 300267 CDS YP_405408.1 82779059 3797670 complement(3729561..3730526) 1 NC_007606.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 3730526 rbsC 3797670 rbsC Shigella dysenteriae Sd197 ribose ABC transporter permease YP_405408.1 3729561 R 300267 CDS YP_405409.1 82779060 3797671 complement(3730634..3731029) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3731029 3797671 SDY_3998 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405409.1 3730634 R 300267 CDS YP_009000847.1 578793325 18263161 complement(3731056..3731328) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3731328 18263161 SDY_4774 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000847.1 3731056 R 300267 CDS YP_405410.1 82779061 3797674 complement(3733404..3735278) 1 NC_007606.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 3735278 trkD 3797674 trkD Shigella dysenteriae Sd197 potassium transport protein Kup YP_405410.1 3733404 R 300267 CDS YP_405411.2 228861758 3797675 3735501..3736997 1 NC_007606.1 ''interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase''; regulatory ATPase RavA 3736997 yieN 3797675 yieN Shigella dysenteriae Sd197 regulatory ATPase RavA YP_405411.2 3735501 D 300267 CDS YP_405412.1 82779063 3797676 3736991..3738442 1 NC_007606.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 3738442 yieM 3797676 yieM Shigella dysenteriae Sd197 hypothetical protein YP_405412.1 3736991 D 300267 CDS YP_405413.1 82779064 3797677 complement(3738447..3739439) 1 NC_007606.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 3739439 asnA 3797677 asnA Shigella dysenteriae Sd197 asparagine synthetase AsnA YP_405413.1 3738447 R 300267 CDS YP_405414.1 82779065 3797678 3739591..3740049 1 NC_007606.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 3740049 asnC 3797678 asnC Shigella dysenteriae Sd197 DNA-binding transcriptional regulator AsnC YP_405414.1 3739591 D 300267 CDS YP_405415.1 82779066 3797679 3740139..3740582 1 NC_007606.1 ''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''; flavodoxin 3740582 mioC 3797679 mioC Shigella dysenteriae Sd197 flavodoxin YP_405415.1 3740139 D 300267 CDS YP_405416.1 82779067 3797680 3740961..3742850 1 NC_007606.1 possibly involved in chromosome replication; GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 3742850 gidA 3797680 gidA Shigella dysenteriae Sd197 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_405416.1 3740961 D 300267 CDS YP_405417.1 82779068 3797681 3742914..3743537 1 NC_007606.1 possibly involved in chromosome replication; glucose-inhibited division; glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 3743537 gidB 3797681 gidB Shigella dysenteriae Sd197 16S rRNA methyltransferase GidB YP_405417.1 3742914 D 300267 CDS YP_405418.2 161950004 3797682 3744154..3744534 1 NC_007606.1 dispensable protein; affects expression of atpB; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 3744534 atpI 3797682 atpI Shigella dysenteriae Sd197 F0F1 ATP synthase subunit I YP_405418.2 3744154 D 300267 CDS YP_405419.1 82779070 3797683 3744543..3745358 1 NC_007606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 3745358 atpB 3797683 atpB Shigella dysenteriae Sd197 ATP synthase F0F1 subunit A YP_405419.1 3744543 D 300267 CDS YP_405420.1 82779071 3797684 3745405..3745644 1 NC_007606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 3745644 atpE 3797684 atpE Shigella dysenteriae Sd197 ATP synthase F0F1 subunit C YP_405420.1 3745405 D 300267 CDS YP_405421.1 82779072 3797685 3745706..3746176 1 NC_007606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 3746176 atpF 3797685 atpF Shigella dysenteriae Sd197 ATP synthase F0F1 subunit B YP_405421.1 3745706 D 300267 CDS YP_405422.1 82779073 3797686 3746191..3746724 1 NC_007606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 3746724 atpH 3797686 atpH Shigella dysenteriae Sd197 ATP synthase F0F1 subunit delta YP_405422.1 3746191 D 300267 CDS YP_405423.1 82779074 3797687 3746737..3748278 1 NC_007606.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 3748278 atpA 3797687 atpA Shigella dysenteriae Sd197 ATP synthase F0F1 subunit alpha YP_405423.1 3746737 D 300267 CDS YP_405424.1 82779075 3797688 3748329..3749192 1 NC_007606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 3749192 atpG 3797688 atpG Shigella dysenteriae Sd197 ATP synthase F0F1 subunit gamma YP_405424.1 3748329 D 300267 CDS YP_405425.1 82779076 3797689 3749219..3750601 1 NC_007606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 3750601 atpD 3797689 atpD Shigella dysenteriae Sd197 ATP synthase F0F1 subunit beta YP_405425.1 3749219 D 300267 CDS YP_405426.1 82779077 3796862 3750622..3751041 1 NC_007606.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 3751041 atpC 3796862 atpC Shigella dysenteriae Sd197 ATP synthase F0F1 subunit epsilon YP_405426.1 3750622 D 300267 CDS YP_405427.1 82779078 3796863 3751393..3752763 1 NC_007606.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 3752763 glmU 3796863 glmU Shigella dysenteriae Sd197 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_405427.1 3751393 D 300267 CDS YP_405428.1 82779079 3796864 3752925..3754754 1 NC_007606.1 ''Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source''; glucosamine--fructose-6-phosphate aminotransferase 3754754 glmS 3796864 glmS Shigella dysenteriae Sd197 glucosamine--fructose-6-phosphate aminotransferase YP_405428.1 3752925 D 300267 CDS YP_405429.1 82779080 3796865 complement(3755155..3756363) 1 NC_007606.1 insertion sequence element IS1294 transposase 3756363 3796865 SDY_4020 Shigella dysenteriae Sd197 insertion sequence element IS1294 transposase YP_405429.1 3755155 R 300267 CDS YP_405430.1 82779081 3796866 complement(3756344..3756616) 1 NC_007606.1 hypothetical protein 3756616 3796866 SDY_4021 Shigella dysenteriae Sd197 hypothetical protein YP_405430.1 3756344 R 300267 CDS YP_405431.1 82779082 3796867 3756878..3757918 1 NC_007606.1 periplasmic phosphate-binding protein; Code: P; COG: COG0226; phosphate ABC transporter substrate-binding protein 3757918 pstS 3796867 pstS Shigella dysenteriae Sd197 phosphate ABC transporter substrate-binding protein YP_405431.1 3756878 D 300267 CDS YP_405432.1 82779083 3796868 3758004..3759005 1 NC_007606.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PstC 3759005 pstC 3796868 pstC Shigella dysenteriae Sd197 phosphate transporter permease PstC YP_405432.1 3758004 D 300267 CDS YP_405433.1 82779084 3796869 3759005..3759895 1 NC_007606.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease PtsA 3759895 pstA 3796869 pstA Shigella dysenteriae Sd197 phosphate transporter permease PtsA YP_405433.1 3759005 D 300267 CDS YP_405434.1 82779085 3796870 3760078..3760851 1 NC_007606.1 Code: P; COG: COG1117; phosphate transporter subunit 3760851 pstB 3796870 pstB Shigella dysenteriae Sd197 phosphate transporter subunit YP_405434.1 3760078 D 300267 CDS YP_405435.1 82779086 3796871 3760866..3761591 1 NC_007606.1 enzyme in phosphate metabolism; regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 3761591 phoU 3796871 phoU Shigella dysenteriae Sd197 transcriptional regulator PhoU YP_405435.1 3760866 D 300267 CDS YP_405436.1 82779087 3796872 3762014..3763675 1 NC_007606.1 hypothetical protein 3763675 3796872 SDY_4027 Shigella dysenteriae Sd197 hypothetical protein YP_405436.1 3762014 D 300267 CDS YP_405437.1 82779088 3796873 3763990..3764493 1 NC_007606.1 hypothetical protein 3764493 3796873 SDY_4028 Shigella dysenteriae Sd197 hypothetical protein YP_405437.1 3763990 D 300267 CDS YP_405438.1 82779089 3796874 3764736..3765011 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3765011 insA 3796874 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405438.1 3764736 D 300267 CDS YP_405439.1 82779090 3796875 3765056..3765433 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3765433 insB 3796875 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405439.1 3765056 D 300267 CDS YP_009000848.1 578793326 18263162 3766246..3766518 1 NC_007606.1 insertion element iso-IS1N protein InsA 3766518 18263162 SDY_4775 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000848.1 3766246 D 300267 CDS YP_405442.1 82779093 3796878 3767585..3768784 1 NC_007606.1 hypothetical protein 3768784 3796878 SDY_4033 Shigella dysenteriae Sd197 hypothetical protein YP_405442.1 3767585 D 300267 CDS YP_405443.1 82779094 3796879 3769333..3771840 1 NC_007606.1 Code: UW; COG: COG5295; hypothetical protein 3771840 3796879 SDY_4034 Shigella dysenteriae Sd197 hypothetical protein YP_405443.1 3769333 D 300267 CDS YP_405444.1 82779095 3796880 3771929..3772765 1 NC_007606.1 hypothetical protein 3772765 3796880 SDY_4035 Shigella dysenteriae Sd197 hypothetical protein YP_405444.1 3771929 D 300267 CDS YP_405445.1 82779096 3795518 3773192..3774847 1 NC_007606.1 Code: C; COG: COG1620; L-lactate permease 3774847 lldP 3795518 lldP Shigella dysenteriae Sd197 L-lactate permease YP_405445.1 3773192 D 300267 CDS YP_405446.1 82779097 3795519 3774847..3775623 1 NC_007606.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 3775623 lldR 3795519 lldR Shigella dysenteriae Sd197 DNA-binding transcriptional repressor LldR YP_405446.1 3774847 D 300267 CDS YP_405447.1 82779098 3795520 3775620..3776810 1 NC_007606.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 3776810 lldD 3795520 lldD Shigella dysenteriae Sd197 L-lactate dehydrogenase YP_405447.1 3775620 D 300267 CDS YP_405448.1 82779099 3795521 3776996..3777469 1 NC_007606.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 3777469 yibK 3795521 yibK Shigella dysenteriae Sd197 tRNA/rRNA methyltransferase YibK YP_405448.1 3776996 D 300267 CDS YP_405449.1 82779100 3795522 complement(3777522..3778343) 1 NC_007606.1 catalyzes the O-acetylation of serine; serine acetyltransferase 3778343 cysE 3795522 cysE Shigella dysenteriae Sd197 serine acetyltransferase YP_405449.1 3777522 R 300267 CDS YP_405450.1 82779101 3795523 complement(3778423..3779442) 1 NC_007606.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 3779442 gpsA 3795523 gpsA Shigella dysenteriae Sd197 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_405450.1 3778423 R 300267 CDS YP_405451.1 82779102 3795524 complement(3779442..3779909) 1 NC_007606.1 protein export; molecular chaperone; may bind to signel sequence; molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 3779909 secB 3795524 secB Shigella dysenteriae Sd197 preprotein translocase subunit SecB YP_405451.1 3779442 R 300267 CDS YP_405452.1 82779103 3795525 complement(3779972..3780223) 1 NC_007606.1 Code: O; COG: COG0695; glutaredoxin 3 3780223 grxC 3795525 grxC Shigella dysenteriae Sd197 glutaredoxin 3 YP_405452.1 3779972 R 300267 CDS YP_405453.1 82779104 3795526 complement(3780365..3780796) 1 NC_007606.1 Code: P; COG: COG0607; hypothetical protein 3780796 yibN 3795526 yibN Shigella dysenteriae Sd197 hypothetical protein YP_405453.1 3780365 R 300267 CDS YP_405454.1 82779105 3795527 3781041..3782585 1 NC_007606.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 3782585 yibO 3795527 yibO Shigella dysenteriae Sd197 phosphoglyceromutase YP_405454.1 3781041 D 300267 CDS YP_405455.1 82779106 3795528 3782595..3783878 1 NC_007606.1 Code: D; COG: COG4942; hypothetical protein 3783878 yibP 3795528 yibP Shigella dysenteriae Sd197 hypothetical protein YP_405455.1 3782595 D 300267 CDS YP_405456.1 82779107 3795529 3784008..3784841 1 NC_007606.1 Code: S; COG: COG2861; hypothetical protein 3784841 yibQ 3795529 yibQ Shigella dysenteriae Sd197 hypothetical protein YP_405456.1 3784008 D 300267 CDS YP_405457.1 82779108 3795530 complement(3784847..3785851) 1 NC_007606.1 Code: M; COG: COG0463; glycosyl transferase 3785851 yibD 3795530 yibD Shigella dysenteriae Sd197 glycosyl transferase YP_405457.1 3784847 R 300267 CDS YP_405458.1 82779109 3795531 complement(3786090..3787115) 1 NC_007606.1 ''converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism''; L-threonine 3-dehydrogenase 3787115 tdh 3795531 tdh Shigella dysenteriae Sd197 L-threonine 3-dehydrogenase YP_405458.1 3786090 R 300267 CDS YP_405459.1 82779110 3795532 complement(3787125..3788321) 1 NC_007606.1 glycine acetyltransferase; catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 3788321 kbl 3795532 kbl Shigella dysenteriae Sd197 2-amino-3-ketobutyrate CoA ligase YP_405459.1 3787125 R 300267 CDS YP_405460.1 82779111 3795533 3788535..3789467 1 NC_007606.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 3789467 rfaD 3795533 rfaD Shigella dysenteriae Sd197 ADP-L-glycero-D-manno-heptose-6-epimerase YP_405460.1 3788535 D 300267 CDS YP_405461.1 82779112 3795534 3789477..3790523 1 NC_007606.1 lipopolysaccharide core biosynthesis; catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 3790523 rfaF 3795534 rfaF Shigella dysenteriae Sd197 ADP-heptose--LPS heptosyltransferase YP_405461.1 3789477 D 300267 CDS YP_405462.1 82779113 3795535 3790527..3791486 1 NC_007606.1 lipopolysaccharide core biosynthesis; Code: M; COG: COG0859; ADP-heptose--LPS heptosyltransferase 3791486 rfaC 3795535 rfaC Shigella dysenteriae Sd197 ADP-heptose--LPS heptosyltransferase YP_405462.1 3790527 D 300267 CDS YP_405463.1 82779114 3795536 complement(3791534..3792787) 1 NC_007606.1 lipid A-core:surface polymer ligase WaaL 3792787 waaL 3795536 waaL Shigella dysenteriae Sd197 lipid A-core:surface polymer ligase WaaL YP_405463.1 3791534 R 300267 CDS YP_405464.1 82779115 3795537 complement(3792822..3793595) 1 NC_007606.1 Code: M; COG: COG3306; beta 1,4-galactosyltransferase WaaX 3793595 waaX 3795537 waaX Shigella dysenteriae Sd197 beta 1,4-galactosyltransferase WaaX YP_405464.1 3792822 R 300267 CDS YP_405465.1 82779116 3795828 complement(3793627..3794655) 1 NC_007606.1 Code: M; COG: COG1442; UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase 3794655 waaW 3795828 waaW Shigella dysenteriae Sd197 UDP-galactose:(galactosyl) LPS alpha1,2-galactosyltransferase YP_405465.1 3793627 R 300267 CDS YP_405466.1 82779117 3795829 complement(3794681..3795373) 1 NC_007606.1 lipopolysaccharide core biosynthesis protein 3795373 rfaY 3795829 rfaY Shigella dysenteriae Sd197 lipopolysaccharide core biosynthesis protein YP_405466.1 3794681 R 300267 CDS YP_405467.1 82779118 3795830 complement(3795383..3796378) 1 NC_007606.1 Code: M; COG: COG1442; lipopolysaccharide 1,2-glucosyltransferase 3796378 rfaJ 3795830 rfaJ Shigella dysenteriae Sd197 lipopolysaccharide 1,2-glucosyltransferase YP_405467.1 3795383 R 300267 CDS YP_405468.1 82779119 3795831 complement(3796395..3797411) 1 NC_007606.1 Code: M; COG: COG1442; lipopolysaccharide 1,3-galactosyltransferase 3797411 rfaI 3795831 rfaI Shigella dysenteriae Sd197 lipopolysaccharide 1,3-galactosyltransferase YP_405468.1 3796395 R 300267 CDS YP_405469.1 82779120 3795832 complement(3797427..3798233) 1 NC_007606.1 LPS biosynthesis protein 3798233 waaP 3795832 waaP Shigella dysenteriae Sd197 LPS biosynthesis protein YP_405469.1 3797427 R 300267 CDS YP_405470.1 82779121 3795833 complement(3798217..3799341) 1 NC_007606.1 lipopolysaccharide core biosynthesis; Code: M; COG: COG0438; glucosyltransferase I 3799341 rfaG 3795833 rfaG Shigella dysenteriae Sd197 glucosyltransferase I YP_405470.1 3798217 R 300267 CDS YP_405471.1 82779122 3795834 complement(3799338..3800396) 1 NC_007606.1 Code: M; COG: COG0859; lipopolysaccharide core biosynthesis protein 3800396 waaQ 3795834 waaQ Shigella dysenteriae Sd197 lipopolysaccharide core biosynthesis protein YP_405471.1 3799338 R 300267 CDS YP_405472.1 82779123 3795835 3800809..3802086 1 NC_007606.1 KDO transferase; catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3802086 kdtA 3795835 kdtA Shigella dysenteriae Sd197 3-deoxy-D-manno-octulosonic-acid transferase YP_405472.1 3800809 D 300267 CDS YP_405473.1 82779124 3795836 3802094..3802573 1 NC_007606.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3802573 coaD 3795836 coaD Shigella dysenteriae Sd197 phosphopantetheine adenylyltransferase YP_405473.1 3802094 D 300267 CDS YP_405474.1 82779125 3795837 complement(3802612..3803421) 1 NC_007606.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3803421 mutM 3795837 mutM Shigella dysenteriae Sd197 formamidopyrimidine-DNA glycosylase YP_405474.1 3802612 R 300267 CDS YP_405475.1 82779126 3795838 complement(3803519..3803686) 1 NC_007606.1 ''in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif''; 50S ribosomal protein L33 3803686 rpmG 3795838 rpmG Shigella dysenteriae Sd197 50S ribosomal protein L33 YP_405475.1 3803519 R 300267 CDS YP_405476.1 82779127 3795839 complement(3803707..3803943) 1 NC_007606.1 required for 70S ribosome assembly; 50S ribosomal protein L28 3803943 rpmB 3795839 rpmB Shigella dysenteriae Sd197 50S ribosomal protein L28 YP_405476.1 3803707 R 300267 CDS YP_405477.1 82779128 3795840 complement(3804160..3804834) 1 NC_007606.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 3804834 radC 3795840 radC Shigella dysenteriae Sd197 DNA repair protein RadC YP_405477.1 3804160 R 300267 CDS YP_405478.2 161950003 3795841 3805000..3806220 1 NC_007606.1 flavoprotein affecting synthesis of DNA and pantothenate metabolism; ''catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine''; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3806220 dfp 3795841 dfp Shigella dysenteriae Sd197 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_405478.2 3805000 D 300267 CDS YP_405479.1 82779130 3795842 3806201..3806656 1 NC_007606.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3806656 dut 3795842 dut Shigella dysenteriae Sd197 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_405479.1 3806201 D 300267 CDS YP_405480.2 161950002 3795843 3806763..3807359 1 NC_007606.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3807359 slmA 3795843 slmA Shigella dysenteriae Sd197 nucleoid occlusion protein YP_405480.2 3806763 D 300267 CDS YP_405482.1 82779133 3795845 complement(3808651..3809292) 1 NC_007606.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 3809292 pyrE 3795845 pyrE Shigella dysenteriae Sd197 orotate phosphoribosyltransferase YP_405482.1 3808651 R 300267 CDS YP_405483.1 82779134 3795846 complement(3809358..3810074) 1 NC_007606.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 3810074 rph 3795846 rph Shigella dysenteriae Sd197 ribonuclease PH YP_405483.1 3809358 R 300267 CDS YP_405484.1 82779135 3795749 3810201..3811064 1 NC_007606.1 Code: S; COG: COG1561; hypothetical protein 3811064 yicC 3795749 yicC Shigella dysenteriae Sd197 hypothetical protein YP_405484.1 3810201 D 300267 CDS YP_405485.2 161950001 3795750 3811284..3812108 1 NC_007606.1 DNA-damage-inducible protein D 3812108 dinD 3795750 dinD Shigella dysenteriae Sd197 DNA-damage-inducible protein D YP_405485.2 3811284 D 300267 CDS YP_405486.1 82779137 3795751 3812346..3813017 1 NC_007606.1 Code: S; COG: COG2860; hypothetical protein 3813017 yicG 3795751 yicG Shigella dysenteriae Sd197 hypothetical protein YP_405486.1 3812346 D 300267 CDS YP_405488.1 82779139 3795754 3814950..3815573 1 NC_007606.1 ''Essential for recycling GMP and indirectly, cGMP''; guanylate kinase 3815573 gmk 3795754 gmk Shigella dysenteriae Sd197 guanylate kinase YP_405488.1 3814950 D 300267 CDS YP_405489.1 82779140 3795755 3815628..3815903 1 NC_007606.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3815903 rpoZ 3795755 rpoZ Shigella dysenteriae Sd197 DNA-directed RNA polymerase subunit omega YP_405489.1 3815628 D 300267 CDS YP_405490.1 82779141 3795756 3815922..3818030 1 NC_007606.1 also guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Code: TK; COG: COG0317; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3818030 spoT 3795756 spoT Shigella dysenteriae Sd197 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_405490.1 3815922 D 300267 CDS YP_405491.1 82779142 3795757 3818037..3818726 1 NC_007606.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3818726 spoU 3795757 spoU Shigella dysenteriae Sd197 tRNA guanosine-2'-O-methyltransferase YP_405491.1 3818037 D 300267 CDS YP_405492.1 82779143 3795758 3818732..3820813 1 NC_007606.1 resolution of Holliday junctions; branch migration; catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3820813 recG 3795758 recG Shigella dysenteriae Sd197 ATP-dependent DNA helicase RecG YP_405492.1 3818732 D 300267 CDS YP_405493.1 82779144 3795759 complement(3820989..3822194) 1 NC_007606.1 Code: E; COG: COG0786; glutamate transport 3822194 gltS 3795759 gltS Shigella dysenteriae Sd197 glutamate transport YP_405493.1 3820989 R 300267 CDS YP_405494.1 82779145 3795760 3822473..3823864 1 NC_007606.1 Code: F; COG: COG2233; transport protein 3823864 yicE 3795760 yicE Shigella dysenteriae Sd197 transport protein YP_405494.1 3822473 D 300267 CDS YP_405495.1 82779146 3795761 3823985..3825694 1 NC_007606.1 hypothetical protein 3825694 yicH 3795761 yicH Shigella dysenteriae Sd197 hypothetical protein YP_405495.1 3823985 D 300267 CDS YP_405496.1 82779147 3795763 3826217..3826519 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 3826519 3795763 SDY_4089 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_405496.1 3826217 D 300267 CDS YP_405498.1 82779149 3795766 complement(3828164..3829519) 1 NC_007606.1 Code: G; COG: COG1486; alpha-galactosidase 3829519 melA 3795766 melA Shigella dysenteriae Sd197 alpha-galactosidase YP_405498.1 3828164 R 300267 CDS YP_405499.1 82779150 3795768 3830790..3833060 1 NC_007606.1 Code: E; COG: COG1982; biodegradative arginine decarboxylase 3833060 adiA 3795768 adiA Shigella dysenteriae Sd197 biodegradative arginine decarboxylase YP_405499.1 3830790 D 300267 CDS YP_405500.1 82779151 3799421 3833180..3833455 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3833455 insA 3799421 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405500.1 3833180 D 300267 CDS YP_405501.1 82779152 3799422 3833500..3833877 1 NC_007606.1 Code: L; COG: COG1662; insertion sequence element IS1 transposase 3833877 insB 3799422 insB Shigella dysenteriae Sd197 insertion sequence element IS1 transposase YP_405501.1 3833500 D 300267 CDS YP_405502.1 82779153 3799423 3834162..3834923 1 NC_007606.1 Code: K; COG: COG2207; AraC family transcriptional regulator 3834923 adiY 3799423 adiY Shigella dysenteriae Sd197 AraC family transcriptional regulator YP_405502.1 3834162 D 300267 CDS YP_405503.1 82779154 3799424 3835060..3836397 1 NC_007606.1 Code: E; COG: COG0531; arginine:agmatin antiporter 3836397 yjdE 3799424 yjdE Shigella dysenteriae Sd197 arginine:agmatin antiporter YP_405503.1 3835060 D 300267 CDS YP_405504.1 82779155 3799425 3836456..3838144 1 NC_007606.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 3838144 yjdB 3799425 yjdB Shigella dysenteriae Sd197 cell division protein YP_405504.1 3836456 D 300267 CDS YP_405505.1 82779156 3799427 3838799..3839890 1 NC_007606.1 Code: T; COG: COG0642; sensor protein BasS/PmrB 3839890 basS 3799427 basS Shigella dysenteriae Sd197 sensor protein BasS/PmrB YP_405505.1 3838799 D 300267 CDS YP_405506.1 82779157 3799428 complement(3840067..3841569) 1 NC_007606.1 low-affinity transport system; Code: GEPR; COG: COG0477; proline/glycine betaine transporter 3841569 proP 3799428 proP Shigella dysenteriae Sd197 proline/glycine betaine transporter YP_405506.1 3840067 R 300267 CDS YP_405507.1 82779158 3799429 complement(3841833..3842678) 1 NC_007606.1 hypothetical protein 3842678 yjcZ 3799429 yjcZ Shigella dysenteriae Sd197 hypothetical protein YP_405507.1 3841833 R 300267 CDS YP_405508.1 82779159 3799430 3844513..3844788 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3844788 insA 3799430 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405508.1 3844513 D 300267 CDS YP_405509.1 82779160 3799431 3844833..3845210 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3845210 insB 3799431 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405509.1 3844833 D 300267 CDS YP_405510.1 82779161 3799433 complement(3845798..3846175) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3846175 insB 3799433 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405510.1 3845798 R 300267 CDS YP_405511.1 82779162 3799434 complement(3846220..3846495) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3846495 insA 3799434 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405511.1 3846220 R 300267 CDS YP_405512.1 82779163 3799435 3846892..3847227 1 NC_007606.1 Code: P; COG: COG2824; hypothetical protein 3847227 phnA 3799435 phnA Shigella dysenteriae Sd197 hypothetical protein YP_405512.1 3846892 D 300267 CDS YP_405513.1 82779164 3799437 3847963..3848751 1 NC_007606.1 Code: P; COG: COG3638; phosphonate/organophosphate ester ABC transporter ATP-binding protein 3848751 phnC 3799437 phnC Shigella dysenteriae Sd197 phosphonate/organophosphate ester ABC transporter ATP-binding protein YP_405513.1 3847963 D 300267 CDS YP_405514.1 82779165 3799438 3848776..3849792 1 NC_007606.1 Code: P; COG: COG3221; phosphonate/organophosphate ester ABC transporter substrate-binding protein 3849792 phnD 3799438 phnD Shigella dysenteriae Sd197 phosphonate/organophosphate ester ABC transporter substrate-binding protein YP_405514.1 3848776 D 300267 CDS YP_405515.1 82779166 3799439 3849847..3850677 1 NC_007606.1 Code: P; COG: COG3639; phosphonate/organophosphate ester ABC transporter permease 3850677 phnE 3799439 phnE Shigella dysenteriae Sd197 phosphonate/organophosphate ester ABC transporter permease YP_405515.1 3849847 D 300267 CDS YP_405516.1 82779167 3798881 3850698..3851423 1 NC_007606.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 3851423 phnF 3798881 phnF Shigella dysenteriae Sd197 phosphonate metabolism transcriptional regulator PhnF YP_405516.1 3850698 D 300267 CDS YP_405517.1 82779168 3798883 3851860..3852444 1 NC_007606.1 Code: P; COG: COG3625; carbon-phosphorus lyase complex subunit 3852444 phnH 3798883 phnH Shigella dysenteriae Sd197 carbon-phosphorus lyase complex subunit YP_405517.1 3851860 D 300267 CDS YP_405518.1 82779169 3798884 3852444..3853508 1 NC_007606.1 Code: P; COG: COG3626; phosphonate metabolism protein 3853508 phnI 3798884 phnI Shigella dysenteriae Sd197 phosphonate metabolism protein YP_405518.1 3852444 D 300267 CDS YP_405519.1 82779170 3798885 3853501..3854346 1 NC_007606.1 Code: P; COG: COG3627; phosphonate metabolism protein 3854346 phnJ 3798885 phnJ Shigella dysenteriae Sd197 phosphonate metabolism protein YP_405519.1 3853501 D 300267 CDS YP_405520.1 82779171 3798886 3854343..3855101 1 NC_007606.1 Code: P; COG: COG4107; phosphonate C-P lyase system protein PhnK 3855101 phnK 3798886 phnK Shigella dysenteriae Sd197 phosphonate C-P lyase system protein PhnK YP_405520.1 3854343 D 300267 CDS YP_405521.1 82779172 3798887 3855212..3855892 1 NC_007606.1 Code: P; COG: COG4778; phosphonate ABC transporter ATP-binding protein 3855892 phnL 3798887 phnL Shigella dysenteriae Sd197 phosphonate ABC transporter ATP-binding protein YP_405521.1 3855212 D 300267 CDS YP_405522.1 82779173 3798888 3855889..3856941 1 NC_007606.1 Code: P; COG: COG3454; phosphonate metabolism protein 3856941 phnM 3798888 phnM Shigella dysenteriae Sd197 phosphonate metabolism protein YP_405522.1 3855889 D 300267 CDS YP_405523.1 82779174 3798889 3856941..3857498 1 NC_007606.1 Code: P; COG: COG3709; ribose 1,5-bisphosphokinase 3857498 phnN 3798889 phnN Shigella dysenteriae Sd197 ribose 1,5-bisphosphokinase YP_405523.1 3856941 D 300267 CDS YP_405524.1 82779175 3798890 3857485..3857919 1 NC_007606.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 3857919 phnO 3798890 phnO Shigella dysenteriae Sd197 aminoalkylphosphonic acid N-acetyltransferase YP_405524.1 3857485 D 300267 CDS YP_405525.1 82779176 3798891 3857921..3858679 1 NC_007606.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 3858679 phnP 3798891 phnP Shigella dysenteriae Sd197 carbon-phosphorus lyase complex accessory protein YP_405525.1 3857921 D 300267 CDS YP_405526.1 82779177 3798892 complement(3858756..3859085) 1 NC_007606.1 hypothetical protein 3859085 3798892 SDY_4125 Shigella dysenteriae Sd197 hypothetical protein YP_405526.1 3858756 R 300267 CDS YP_405527.1 82779178 3798893 complement(3859154..3859909) 1 NC_007606.1 hypothetical protein 3859909 3798893 SDY_4126 Shigella dysenteriae Sd197 hypothetical protein YP_405527.1 3859154 R 300267 CDS YP_405528.1 82779179 3798894 complement(3859899..3862163) 1 NC_007606.1 Code: T; COG: COG0642; histidine kinase 3862163 3798894 SDY_4127 Shigella dysenteriae Sd197 histidine kinase YP_405528.1 3859899 R 300267 CDS YP_405529.1 82779180 3798895 3862277..3863764 1 NC_007606.1 Code: G; COG: COG1129; ribose ABC transporter ATP-binding protein 3863764 3798895 SDY_4128 Shigella dysenteriae Sd197 ribose ABC transporter ATP-binding protein YP_405529.1 3862277 D 300267 CDS YP_405531.1 82779182 3798897 3864769..3865710 1 NC_007606.1 Code: G; COG: COG1879; ribose ABC transporter substrate-binding protein 3865710 3798897 SDY_4130 Shigella dysenteriae Sd197 ribose ABC transporter substrate-binding protein YP_405531.1 3864769 D 300267 CDS YP_405532.1 82779183 3798898 3865765..3866448 1 NC_007606.1 Code: R; COG: COG3822; hypothetical protein 3866448 3798898 SDY_4131 Shigella dysenteriae Sd197 hypothetical protein YP_405532.1 3865765 D 300267 CDS YP_405533.1 82779184 3798899 3866463..3867323 1 NC_007606.1 Code: G; COG: COG0191; hypothetical protein 3867323 3798899 SDY_4132 Shigella dysenteriae Sd197 hypothetical protein YP_405533.1 3866463 D 300267 CDS YP_405534.1 82779185 3798900 3867320..3868321 1 NC_007606.1 Code: G; COG: COG0524; kinase 3868321 3798900 SDY_4133 Shigella dysenteriae Sd197 kinase YP_405534.1 3867320 D 300267 CDS YP_405535.1 82779186 3797218 complement(3868318..3869043) 1 NC_007606.1 Code: TK; COG: COG0745; transcriptional regulator 3869043 3797218 SDY_4134 Shigella dysenteriae Sd197 transcriptional regulator YP_405535.1 3868318 R 300267 CDS YP_405536.1 82779187 3797219 complement(3869067..3869462) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3869462 3797219 SDY_4135 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405536.1 3869067 R 300267 CDS YP_009000849.1 578793327 18263163 complement(3869489..3869761) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3869761 18263163 SDY_4776 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000849.1 3869489 R 300267 CDS YP_405537.1 82779188 3797220 complement(3869814..3870608) 1 NC_007606.1 hypothetical protein 3870608 3797220 SDY_4136 Shigella dysenteriae Sd197 hypothetical protein YP_405537.1 3869814 R 300267 CDS YP_405538.1 82779189 3797221 complement(3870707..3872221) 1 NC_007606.1 hypothetical protein 3872221 3797221 SDY_4137 Shigella dysenteriae Sd197 hypothetical protein YP_405538.1 3870707 R 300267 CDS YP_405540.1 82779191 3797223 3872967..3873242 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3873242 insA 3797223 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405540.1 3872967 D 300267 CDS YP_405541.1 82779192 3797224 3873287..3873664 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3873664 insB 3797224 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405541.1 3873287 D 300267 CDS YP_405542.2 161950000 3797225 complement(3873880..3875064) 1 NC_007606.1 Code: G; COG: COG2814; transport protein 3875064 yicM 3797225 yicM Shigella dysenteriae Sd197 transport protein YP_405542.2 3873880 R 300267 CDS YP_405543.1 82779194 3797226 3875292..3875651 1 NC_007606.1 Code: S; COG: COG4737; hypothetical protein 3875651 3797226 SDY_4142 Shigella dysenteriae Sd197 hypothetical protein YP_405543.1 3875292 D 300267 CDS YP_405544.1 82779195 3797227 3875635..3875958 1 NC_007606.1 Code: K; COG: COG2944; DNA-binding protein 3875958 3797227 SDY_4143 Shigella dysenteriae Sd197 DNA-binding protein YP_405544.1 3875635 D 300267 CDS YP_405545.1 82779196 3797228 complement(3876073..3876552) 1 NC_007606.1 hypothetical protein 3876552 yicN 3797228 yicN Shigella dysenteriae Sd197 hypothetical protein YP_405545.1 3876073 R 300267 CDS YP_405546.1 82779197 3797230 3878058..3879812 1 NC_007606.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3879812 yicP 3797230 yicP Shigella dysenteriae Sd197 cryptic adenine deaminase YP_405546.1 3878058 D 300267 CDS YP_405547.1 82779198 3797231 complement(3879856..3881247) 1 NC_007606.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 3881247 uhpT 3797231 uhpT Shigella dysenteriae Sd197 sugar phosphate antiporter YP_405547.1 3879856 R 300267 CDS YP_405548.1 82779199 3797232 complement(3881385..3882707) 1 NC_007606.1 membrane protein regulates uhpT expression; regulatory protein UhpC 3882707 uhpC 3797232 uhpC Shigella dysenteriae Sd197 regulatory protein UhpC YP_405548.1 3881385 R 300267 CDS YP_405549.1 82779200 3797233 complement(3882714..3884219) 1 NC_007606.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 3884219 uhpB 3797233 uhpB Shigella dysenteriae Sd197 sensory histidine kinase UhpB YP_405549.1 3882714 R 300267 CDS YP_405550.1 82779201 3797234 complement(3884216..3884806) 1 NC_007606.1 sensor, uhpB; ''response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter''; DNA-binding transcriptional activator UhpA 3884806 uhpA 3797234 uhpA Shigella dysenteriae Sd197 DNA-binding transcriptional activator UhpA YP_405550.1 3884216 R 300267 CDS YP_405551.1 82779202 3797235 3885501..3885896 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3885896 3797235 SDY_4151 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405551.1 3885501 D 300267 CDS YP_405552.1 82779203 3797236 complement(3886743..3887138) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3887138 3797236 SDY_4152 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405552.1 3886743 R 300267 CDS YP_009000850.1 578793328 18263164 complement(3887165..3887437) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3887437 18263164 SDY_4777 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000850.1 3887165 R 300267 CDS YP_405554.1 82779205 3799171 complement(3888603..3888893) 1 NC_007606.1 ''with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit''; acetolactate synthase 1 regulatory subunit 3888893 ilvN 3799171 ilvN Shigella dysenteriae Sd197 acetolactate synthase 1 regulatory subunit YP_405554.1 3888603 R 300267 CDS YP_405555.1 82779206 3799172 complement(3888897..3890585) 1 NC_007606.1 Code: EH; COG: COG0028; acetolactate synthase catalytic subunit 3890585 ilvB 3799172 ilvB Shigella dysenteriae Sd197 acetolactate synthase catalytic subunit YP_405555.1 3888897 R 300267 CDS YP_405556.1 82779207 3799173 complement(3890691..3890789) 1 NC_007606.1 ilvB operon leader peptide 3890789 ivbL 3799173 ivbL Shigella dysenteriae Sd197 ilvB operon leader peptide YP_405556.1 3890691 R 300267 CDS YP_405557.1 82779208 3799174 3891717..3892907 1 NC_007606.1 multidrug resistance; multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3892907 emrD 3799174 emrD Shigella dysenteriae Sd197 multidrug resistance protein D YP_405557.1 3891717 D 300267 CDS YP_405558.1 82779209 3799175 complement(3892915..3893412) 1 NC_007606.1 Code: R; COG: COG0641; transcriptional regulator 3893412 yidF 3799175 yidF Shigella dysenteriae Sd197 transcriptional regulator YP_405558.1 3892915 R 300267 CDS YP_405559.1 82779210 3799176 complement(3893409..3893771) 1 NC_007606.1 hypothetical protein 3893771 yidG 3799176 yidG Shigella dysenteriae Sd197 hypothetical protein YP_405559.1 3893409 R 300267 CDS YP_405560.1 82779211 3799177 complement(3893761..3894108) 1 NC_007606.1 Code: S; COG: COG2149; hypothetical protein 3894108 yidH 3799177 yidH Shigella dysenteriae Sd197 hypothetical protein YP_405560.1 3893761 R 300267 CDS YP_405561.1 82779212 3799178 3894218..3894667 1 NC_007606.1 hypothetical protein 3894667 yidI 3799178 yidI Shigella dysenteriae Sd197 hypothetical protein YP_405561.1 3894218 D 300267 CDS YP_405562.1 82779213 3799179 complement(3894714..3896207) 1 NC_007606.1 Code: P; COG: COG3119; sulfatase 3896207 yidJ 3799179 yidJ Shigella dysenteriae Sd197 sulfatase YP_405562.1 3894714 R 300267 CDS YP_405563.1 82779214 3799180 complement(3897171..3897548) 1 NC_007606.1 Code: L; COG: COG1662; insertion sequence element IS1 transposase 3897548 insB 3799180 insB Shigella dysenteriae Sd197 insertion sequence element IS1 transposase YP_405563.1 3897171 R 300267 CDS YP_405564.1 82779215 3799181 complement(3897593..3897868) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3897868 insA 3799181 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405564.1 3897593 R 300267 CDS YP_009000851.1 578793329 18263165 3899435..3899707 1 NC_007606.1 insertion element iso-IS1N protein InsA 3899707 18263165 SDY_4778 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000851.1 3899435 D 300267 CDS YP_405565.1 82779216 3799184 3899734..3900129 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3900129 3799184 SDY_4167 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405565.1 3899734 D 300267 CDS YP_405566.1 82779217 3799185 complement(3900527..3901849) 1 NC_007606.1 Code: G; COG: COG1486; 6-phospho-beta-glucosidase 3901849 3799185 SDY_4168 Shigella dysenteriae Sd197 6-phospho-beta-glucosidase YP_405566.1 3900527 R 300267 CDS YP_405567.1 82779218 3799187 3903761..3904477 1 NC_007606.1 Code: K; COG: COG2188; transcriptional regulator 3904477 yidP 3799187 yidP Shigella dysenteriae Sd197 transcriptional regulator YP_405567.1 3903761 D 300267 CDS YP_405568.2 161949999 3799188 complement(3904474..3906135) 1 NC_007606.1 Code: R; COG: COG2985; hypothetical protein 3906135 yidE 3799188 yidE Shigella dysenteriae Sd197 hypothetical protein YP_405568.2 3904474 R 300267 CDS YP_405569.2 161949998 3799189 complement(3906331..3906759) 1 NC_007606.1 ''16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent''; heat shock chaperone IbpB 3906759 ibpB 3799189 ibpB Shigella dysenteriae Sd197 heat shock chaperone IbpB YP_405569.2 3906331 R 300267 CDS YP_405570.1 82779221 3799825 complement(3906871..3907284) 1 NC_007606.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 3907284 ibpA 3799825 ibpA Shigella dysenteriae Sd197 heat shock protein IbpA YP_405570.1 3906871 R 300267 CDS YP_405571.2 161949997 3799826 3907590..3907922 1 NC_007606.1 Code: R; COG: COG5645; hypothetical protein 3907922 yidQ 3799826 yidQ Shigella dysenteriae Sd197 hypothetical protein YP_405571.2 3907590 D 300267 CDS YP_405572.1 82779223 3799827 complement(3907924..3909168) 1 NC_007606.1 hypothetical protein 3909168 yidR 3799827 yidR Shigella dysenteriae Sd197 hypothetical protein YP_405572.1 3907924 R 300267 CDS YP_405573.2 161949996 3799828 3909233..3910297 1 NC_007606.1 FAD/NAD(P)-binding domain; oxidoreductase 3910297 yidS 3799828 yidS Shigella dysenteriae Sd197 oxidoreductase YP_405573.2 3909233 D 300267 CDS YP_009000852.1 578793330 18263166 3911091..3911363 1 NC_007606.1 insertion element iso-IS1N protein InsA 3911363 18263166 SDY_4779 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000852.1 3911091 D 300267 CDS YP_405575.1 82779226 3799831 complement(3912019..3912831) 1 NC_007606.1 ''YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins''; sugar phosphatase 3912831 yidA 3799831 yidA Shigella dysenteriae Sd197 sugar phosphatase YP_405575.1 3912019 R 300267 CDS YP_405576.1 82779227 3799832 complement(3912946..3913344) 1 NC_007606.1 Code: S; COG: COG3753; hypothetical protein 3913344 yidB 3799832 yidB Shigella dysenteriae Sd197 hypothetical protein YP_405576.1 3912946 R 300267 CDS YP_405577.1 82779228 3799833 complement(3913584..3915998) 1 NC_007606.1 type II topoisomerase; ATPase activity; negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 3915998 gyrB 3799833 gyrB Shigella dysenteriae Sd197 DNA gyrase subunit B YP_405577.1 3913584 R 300267 CDS YP_405578.1 82779229 3799834 complement(3916027..3917100) 1 NC_007606.1 ''Required for DNA replication; binds preferentially to single-stranded, linear DNA''; recombination protein F 3917100 recF 3799834 recF Shigella dysenteriae Sd197 recombination protein F YP_405578.1 3916027 R 300267 CDS YP_405579.1 82779230 3799835 complement(3917100..3918200) 1 NC_007606.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3918200 dnaN 3799835 dnaN Shigella dysenteriae Sd197 DNA polymerase III subunit beta YP_405579.1 3917100 R 300267 CDS YP_405580.1 82779231 3799836 complement(3918205..3919608) 1 NC_007606.1 DNA biosynthesis; initiation of chromosome replication; can be transcription regulator; binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself; chromosome replication initiator DnaA 3919608 dnaA 3799836 dnaA Shigella dysenteriae Sd197 chromosome replication initiator DnaA YP_405580.1 3918205 R 300267 CDS YP_405581.1 82779232 3799837 3920215..3920355 1 NC_007606.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3920355 rpmH 3799837 rpmH Shigella dysenteriae Sd197 50S ribosomal protein L34 YP_405581.1 3920215 D 300267 CDS YP_405582.1 82779233 3799838 3920372..3920731 1 NC_007606.1 protein C5; processes tRNA, 4.5S RNA; protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3920731 rnpA 3799838 rnpA Shigella dysenteriae Sd197 ribonuclease P YP_405582.1 3920372 D 300267 CDS YP_405583.1 82779234 3799839 3920695..3920952 1 NC_007606.1 Code: S; COG: COG0759; hypothetical protein 3920952 yidD 3799839 yidD Shigella dysenteriae Sd197 hypothetical protein YP_405583.1 3920695 D 300267 CDS YP_405584.1 82779235 3799840 3920955..3922601 1 NC_007606.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3922601 yidC 3799840 yidC Shigella dysenteriae Sd197 inner membrane protein translocase component YidC YP_405584.1 3920955 D 300267 CDS YP_405585.1 82779236 3799841 3922707..3924071 1 NC_007606.1 thiophene and furan oxidation; ''in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE''; tRNA modification GTPase TrmE 3924071 trmE 3799841 trmE Shigella dysenteriae Sd197 tRNA modification GTPase TrmE YP_405585.1 3922707 D 300267 CDS YP_405586.1 82779237 3799842 complement(3924317..3924712) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 3924712 3799842 SDY_4190 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405586.1 3924317 R 300267 CDS YP_009000853.1 578793331 18263167 complement(3924739..3925011) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3925011 18263167 SDY_4780 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000853.1 3924739 R 300267 CDS YP_405588.1 82779239 3798021 complement(3925682..3926059) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3926059 insB 3798021 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405588.1 3925682 R 300267 CDS YP_405589.1 82779240 3798022 complement(3926104..3926379) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3926379 insA 3798022 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405589.1 3926104 R 300267 CDS YP_405591.1 82779242 3798024 complement(3927304..3927606) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 3927606 3798024 SDY_4195 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_405591.1 3927304 R 300267 CDS YP_405592.1 82779243 3798025 3927700..3927975 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 3927975 insA 3798025 insA Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_405592.1 3927700 D 300267 CDS YP_405593.1 82779244 3798026 3928020..3928397 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3928397 insB 3798026 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405593.1 3928020 D 300267 CDS YP_405594.1 82779245 3798027 complement(3928581..3929246) 1 NC_007606.1 ''YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily''; 6-phosphogluconate phosphatase 3929246 yieH 3798027 yieH Shigella dysenteriae Sd197 6-phosphogluconate phosphatase YP_405594.1 3928581 R 300267 CDS YP_405595.1 82779246 3798028 3929413..3930750 1 NC_007606.1 Code: R; COG: COG2252; membrane/transport protein 3930750 yieG 3798028 yieG Shigella dysenteriae Sd197 membrane/transport protein YP_405595.1 3929413 D 300267 CDS YP_405596.1 82779247 3798030 complement(3931392..3932153) 1 NC_007606.1 Code: H; COG: COG2091; hypothetical protein 3932153 yieE 3798030 yieE Shigella dysenteriae Sd197 hypothetical protein YP_405596.1 3931392 R 300267 CDS YP_405597.1 82779248 3798031 complement(3932298..3933257) 1 NC_007606.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 3933257 yidZ 3798031 yidZ Shigella dysenteriae Sd197 DNA-binding transcriptional regulator YidZ YP_405597.1 3932298 R 300267 CDS YP_405598.1 82779249 3798032 complement(3933232..3934407) 1 NC_007606.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3934407 yidY 3798032 yidY Shigella dysenteriae Sd197 multidrug efflux system protein MdtL YP_405598.1 3933232 R 300267 CDS YP_405599.1 82779250 3798033 complement(3934539..3935726) 1 NC_007606.1 Code: E; COG: COG0814; low affinity tryptophan permease 3935726 tnaB 3798033 tnaB Shigella dysenteriae Sd197 low affinity tryptophan permease YP_405599.1 3934539 R 300267 CDS YP_405600.2 161949995 3798034 complement(3935701..3936606) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3936606 3798034 SDY_4205 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405600.2 3935701 R 300267 CDS YP_405601.1 82779253 3798036 complement(3936564..3936929) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 3936929 3798036 SDY_4207 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_405601.1 3936564 R 300267 CDS YP_009000854.1 578793332 18263168 3937190..3937462 1 NC_007606.1 insertion element iso-IS1N protein InsA 3937462 18263168 SDY_4781 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000854.1 3937190 D 300267 CDS YP_405604.1 82779255 3798038 3937489..3937884 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3937884 3798038 SDY_4209 Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405604.1 3937489 D 300267 CDS YP_405605.1 82779256 3798039 complement(3937859..3941500) 1 NC_007606.1 Code: M; COG: COG3209; rhs element protein RhsA 3941500 rhsA 3798039 rhsA Shigella dysenteriae Sd197 rhs element protein RhsA YP_405605.1 3937859 R 300267 CDS YP_405606.1 82779257 3798040 3941729..3942337 1 NC_007606.1 Code: O; COG: COG0625; glutathione S-transferase 3942337 yibF 3798040 yibF Shigella dysenteriae Sd197 glutathione S-transferase YP_405606.1 3941729 D 300267 CDS YP_405607.1 82779258 3797256 3942435..3943826 1 NC_007606.1 L-seryl-tRNA (Ser) selenium transferase; catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 3943826 selA 3797256 selA Shigella dysenteriae Sd197 selenocysteine synthase YP_405607.1 3942435 D 300267 CDS YP_405608.1 82779259 3797257 3943823..3945667 1 NC_007606.1 Code: J; COG: COG3276; selenocysteinyl-tRNA-specific translation factor 3945667 selB 3797257 selB Shigella dysenteriae Sd197 selenocysteinyl-tRNA-specific translation factor YP_405608.1 3943823 D 300267 CDS YP_009000855.1 578793333 18263169 3945769..3946041 1 NC_007606.1 insertion element iso-IS1N protein InsA 3946041 18263169 SDY_4782 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000855.1 3945769 D 300267 CDS YP_405610.1 82779261 3797259 3947361..3947636 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3947636 insA 3797259 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405610.1 3947361 D 300267 CDS YP_405611.1 82779262 3797260 3947681..3948058 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3948058 insB 3797260 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405611.1 3947681 D 300267 CDS YP_405612.1 82779263 3797262 complement(3950183..3950593) 1 NC_007606.1 Code: S; COG: COG3223; phosphate-starvation-inducible protein PsiE 3950593 yjbA 3797262 yjbA Shigella dysenteriae Sd197 phosphate-starvation-inducible protein PsiE YP_405612.1 3950183 R 300267 CDS YP_405613.1 82779264 3797264 complement(3953184..3953921) 1 NC_007606.1 hypothetical protein 3953921 yjbG 3797264 yjbG Shigella dysenteriae Sd197 hypothetical protein YP_405613.1 3953184 R 300267 CDS YP_405614.1 82779265 3797265 complement(3953918..3954586) 1 NC_007606.1 hypothetical protein 3954586 yjbF 3797265 yjbF Shigella dysenteriae Sd197 hypothetical protein YP_405614.1 3953918 R 300267 CDS YP_405615.1 82779266 3797266 complement(3954670..3954912) 1 NC_007606.1 hypothetical protein 3954912 yjbE 3797266 yjbE Shigella dysenteriae Sd197 hypothetical protein YP_405615.1 3954670 R 300267 CDS YP_405616.1 82779267 3797267 complement(3955296..3955691) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3955691 3797267 SDY_4223 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405616.1 3955296 R 300267 CDS YP_009000856.1 578793334 18263170 complement(3955718..3955990) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3955990 18263170 SDY_4783 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000856.1 3955718 R 300267 CDS YP_405618.1 82779269 3797269 3956304..3957512 1 NC_007606.1 insertion sequence element IS1294 transposase 3957512 3797269 SDY_4225 Shigella dysenteriae Sd197 insertion sequence element IS1294 transposase YP_405618.1 3956304 D 300267 CDS YP_405619.1 82779270 3797270 complement(3957906..3959555) 1 NC_007606.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 3959555 pgi 3797270 pgi Shigella dysenteriae Sd197 glucose-6-phosphate isomerase YP_405619.1 3957906 R 300267 CDS YP_405620.1 82779271 3797271 3960080..3961429 1 NC_007606.1 lysine sensitive; catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 3961429 lysC 3797271 lysC Shigella dysenteriae Sd197 aspartate kinase YP_405620.1 3960080 D 300267 CDS YP_405621.2 161949994 3797272 complement(3961506..3962411) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3962411 3797272 SDY_4228 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405621.2 3961506 R 300267 CDS YP_405622.1 82779273 3797273 complement(3962369..3962734) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 3962734 3797273 SDY_4229 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_405622.1 3962369 R 300267 CDS YP_405623.1 82779274 3795671 complement(3963868..3965514) 1 NC_007606.1 fumarate hydratase Class I; anaerobic isozyme; Code: C; COG: COG1951; fumarase B 3965514 fumB 3795671 fumB Shigella dysenteriae Sd197 fumarase B YP_405623.1 3963868 R 300267 CDS YP_405624.1 82779275 3795672 complement(3965592..3966779) 1 NC_007606.1 ''functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters''; anaerobic C4-dicarboxylate transporter 3966779 dcuB 3795672 dcuB Shigella dysenteriae Sd197 anaerobic C4-dicarboxylate transporter YP_405624.1 3965592 R 300267 CDS YP_405625.1 82779276 3795673 complement(3966914..3967291) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3967291 insB 3795673 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405625.1 3966914 R 300267 CDS YP_405626.1 82779277 3795674 complement(3967336..3967611) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3967611 insA 3795674 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405626.1 3967336 R 300267 CDS YP_405627.1 82779278 3795675 complement(3968233..3968628) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3968628 3795675 SDY_4235 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405627.1 3968233 R 300267 CDS YP_009000857.1 578793335 18263171 complement(3968655..3968927) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3968927 18263171 SDY_4784 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000857.1 3968655 R 300267 CDS YP_405629.1 82779280 3795677 complement(3969054..3969773) 1 NC_007606.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 3969773 yjdG 3795677 yjdG Shigella dysenteriae Sd197 DNA-binding transcriptional activator DcuR YP_405629.1 3969054 R 300267 CDS YP_405630.1 82779281 3795678 complement(3969770..3971401) 1 NC_007606.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 3971401 yjdH 3795678 yjdH Shigella dysenteriae Sd197 sensory histidine kinase DcuS YP_405630.1 3969770 R 300267 CDS YP_405631.1 82779282 3795679 3971582..3971812 1 NC_007606.1 Code: S; COG: COG3592; hypothetical protein 3971812 yjdI 3795679 yjdI Shigella dysenteriae Sd197 hypothetical protein YP_405631.1 3971582 D 300267 CDS YP_405632.1 82779283 3795680 3971824..3972096 1 NC_007606.1 Code: R; COG: COG2388; hypothetical protein 3972096 yjdJ 3795680 yjdJ Shigella dysenteriae Sd197 hypothetical protein YP_405632.1 3971824 D 300267 CDS YP_405633.1 82779284 3795681 complement(3972446..3972841) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3972841 3795681 SDY_4241 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405633.1 3972446 R 300267 CDS YP_009000858.1 578793336 18263172 complement(3972868..3973140) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3973140 18263172 SDY_4785 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000858.1 3972868 R 300267 CDS YP_405634.1 82779285 3795682 3973786..3974163 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3974163 insB 3795682 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405634.1 3973786 D 300267 CDS YP_405635.1 82779286 3795683 complement(3974316..3974711) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 3974711 3795683 SDY_4243 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405635.1 3974316 R 300267 CDS YP_009000859.1 578793337 18263173 complement(3974738..3975010) 1 NC_007606.1 insertion element iso-IS1N protein InsA 3975010 18263173 SDY_4786 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000859.1 3974738 R 300267 CDS YP_405637.1 82779288 3795685 3975164..3975439 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 3975439 insA 3795685 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405637.1 3975164 D 300267 CDS YP_405638.1 82779289 3795686 3975484..3975861 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 3975861 insB 3795686 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405638.1 3975484 D 300267 CDS YP_405639.1 82779290 3795687 3976254..3977756 1 NC_007606.1 Code: G; COG: COG1129; ATPase 3977756 ytfR 3795687 ytfR Shigella dysenteriae Sd197 ATPase YP_405639.1 3976254 D 300267 CDS YP_405640.1 82779291 3795688 3977767..3978696 1 NC_007606.1 Code: G; COG: COG1172; transport system permease 3978696 ytfT 3795688 ytfT Shigella dysenteriae Sd197 transport system permease YP_405640.1 3977767 D 300267 CDS YP_405641.1 82779292 3795689 3978803..3979774 1 NC_007606.1 membrane component of a sugar ABC transporter system; ABC transporter permease 3979774 yjfF 3795689 yjfF Shigella dysenteriae Sd197 ABC transporter permease YP_405641.1 3978803 D 300267 CDS YP_405642.1 82779293 3795690 complement(3979807..3980805) 1 NC_007606.1 ''catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate''; fructose-1,6-bisphosphatase 3980805 fbp 3795690 fbp Shigella dysenteriae Sd197 fructose-1,6-bisphosphatase YP_405642.1 3979807 R 300267 CDS YP_405643.1 82779294 3799112 3980981..3982354 1 NC_007606.1 Code: M; COG: COG0773; ligase 3982354 yjfG 3799112 yjfG Shigella dysenteriae Sd197 ligase YP_405643.1 3980981 D 300267 CDS YP_405644.1 82779295 3799113 complement(3982437..3982982) 1 NC_007606.1 Code: S; COG: COG3028; hypothetical protein 3982982 yjgA 3799113 yjgA Shigella dysenteriae Sd197 hypothetical protein YP_405644.1 3982437 R 300267 CDS YP_405645.1 82779296 3799114 3983076..3984428 1 NC_007606.1 maturation of antibiotic MccB17, see tld genes; protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 3984428 pmbA 3799114 pmbA Shigella dysenteriae Sd197 peptidase PmbA YP_405645.1 3983076 D 300267 CDS YP_009000860.1 578793338 18263174 3984612..3984998 1 NC_007606.1 cytochrome b562 3984998 18263174 SDY_4255a Shigella dysenteriae Sd197 cytochrome b562 YP_009000860.1 3984612 D 300267 CDS YP_405647.1 82779298 3799116 3985189..3985428 1 NC_007606.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 3985428 relB 3799116 relB Shigella dysenteriae Sd197 bifunctional antitoxin/transcriptional repressor RelB YP_405647.1 3985189 D 300267 CDS YP_405648.1 82779299 3799117 complement(3985429..3985893) 1 NC_007606.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 3985893 nrdG 3799117 nrdG Shigella dysenteriae Sd197 anaerobic ribonucleotide reductase-activating protein YP_405648.1 3985429 R 300267 CDS YP_405649.1 82779300 3799118 complement(3986083..3988221) 1 NC_007606.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 3988221 nrdD 3799118 nrdD Shigella dysenteriae Sd197 anaerobic ribonucleoside triphosphate reductase YP_405649.1 3986083 R 300267 CDS YP_405650.1 82779301 3799119 complement(3988615..3990270) 1 NC_007606.1 Code: G; COG: COG0366; trehalose-6-phosphate hydrolase 3990270 treC 3799119 treC Shigella dysenteriae Sd197 trehalose-6-phosphate hydrolase YP_405650.1 3988615 R 300267 CDS YP_405651.1 82779302 3799120 complement(3990320..3991741) 1 NC_007606.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC 3991741 treB 3799120 treB Shigella dysenteriae Sd197 PTS system trehalose(maltose)-specific transporter subunit IIBC YP_405651.1 3990320 R 300267 CDS YP_405652.1 82779303 3799121 complement(3991860..3992807) 1 NC_007606.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 3992807 treR 3799121 treR Shigella dysenteriae Sd197 trehalose repressor YP_405652.1 3991860 R 300267 CDS YP_405653.1 82779304 3799122 3993186..3995882 1 NC_007606.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 3995882 mgtA 3799122 mgtA Shigella dysenteriae Sd197 magnesium-transporting ATPase MgtA YP_405653.1 3993186 D 300267 CDS YP_405654.1 82779305 3799123 complement(3996088..3996513) 1 NC_007606.1 Code: J; COG: COG0251; hypothetical protein 3996513 yjgF 3799123 yjgF Shigella dysenteriae Sd197 hypothetical protein YP_405654.1 3996088 R 300267 CDS YP_405655.1 82779306 3799124 complement(3996547..3997008) 1 NC_007606.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 3997008 pyrI 3799124 pyrI Shigella dysenteriae Sd197 aspartate carbamoyltransferase YP_405655.1 3996547 R 300267 CDS YP_405656.1 82779307 3799125 complement(3997021..3997956) 1 NC_007606.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 3997956 pyrB 3799125 pyrB Shigella dysenteriae Sd197 aspartate carbamoyltransferase YP_405656.1 3997021 R 300267 CDS YP_405657.1 82779308 3799126 complement(3997960..3998094) 1 NC_007606.1 pyrBI operon leader peptide 3998094 pyrL 3799126 pyrL Shigella dysenteriae Sd197 pyrBI operon leader peptide YP_405657.1 3997960 R 300267 CDS YP_405658.1 82779309 3799127 complement(3998374..3998769) 1 NC_007606.1 Code: J; COG: COG0251; hypothetical protein 3998769 yjgH 3799127 yjgH Shigella dysenteriae Sd197 hypothetical protein YP_405658.1 3998374 R 300267 CDS YP_405659.1 82779310 3799128 complement(3998900..3999613) 1 NC_007606.1 Code: IQR; COG: COG1028; oxidoreductase 3999613 yjgI 3799128 yjgI Shigella dysenteriae Sd197 oxidoreductase YP_405659.1 3998900 R 300267 CDS YP_405661.2 578793339 3799130 3999684..4000277 1 NC_007606.1 hypothetical protein 4000277 yjgJ 3799130 yjgJ Shigella dysenteriae Sd197 hypothetical protein YP_405661.2 3999684 D 300267 CDS YP_405660.1 82779311 3799129 3999787..3999951 1 NC_007606.1 hypothetical protein 3999951 3799129 SDY_4268 Shigella dysenteriae Sd197 hypothetical protein YP_405660.1 3999787 D 300267 CDS YP_405662.1 82779313 3796938 4000413..4000874 1 NC_007606.1 Code: G; COG: COG2731; hypothetical protein 4000874 yjgK 3796938 yjgK Shigella dysenteriae Sd197 hypothetical protein YP_405662.1 4000413 D 300267 CDS YP_009000861.1 578793340 18263175 4001036..4001308 1 NC_007606.1 insertion element iso-IS1N protein InsA 4001308 18263175 SDY_4787 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000861.1 4001036 D 300267 CDS YP_405664.1 82779315 3796940 4001938..4002213 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4002213 insA 3796940 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405664.1 4001938 D 300267 CDS YP_405665.1 82779316 3796941 4002258..4002635 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4002635 insB 3796941 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405665.1 4002258 D 300267 CDS YP_405666.1 82779317 3796942 4002735..4003100 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 4003100 3796942 SDY_4274 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_405666.1 4002735 D 300267 CDS YP_405667.2 161949993 3796943 4003058..4003963 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4003963 3796943 SDY_4275 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405667.2 4003058 D 300267 CDS YP_405668.1 82779319 3796944 complement(4004057..4005061) 1 NC_007606.1 ''catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.''; ornithine carbamoyltransferase subunit I 4005061 argI 3796944 argI Shigella dysenteriae Sd197 ornithine carbamoyltransferase subunit I YP_405668.1 4004057 R 300267 CDS YP_405669.1 82779320 3796945 4005223..4005639 1 NC_007606.1 Code: S; COG: COG3076; hypothetical protein 4005639 yjgD 3796945 yjgD Shigella dysenteriae Sd197 hypothetical protein YP_405669.1 4005223 D 300267 CDS YP_405670.2 578793341 3796946 complement(4005684..4006187) 1 NC_007606.1 Code: KR; COG: COG0454; hypothetical protein 4006187 3796946 SDY_4278 Shigella dysenteriae Sd197 hypothetical protein YP_405670.2 4005684 R 300267 CDS YP_405671.1 82779322 3796947 complement(4006225..4006620) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4006620 3796947 SDY_4279 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405671.1 4006225 R 300267 CDS YP_009000862.1 578793342 18263176 complement(4006647..4006919) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4006919 18263176 SDY_4788 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000862.1 4006647 R 300267 CDS YP_009000863.1 578793343 18263177 4007792..4008064 1 NC_007606.1 insertion element iso-IS1N protein InsA 4008064 18263177 SDY_4789 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000863.1 4007792 D 300267 CDS YP_405672.1 82779323 3796949 4008091..4008486 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4008486 3796949 SDY_4281 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405672.1 4008091 D 300267 CDS YP_405673.1 82779324 3796950 complement(4009180..4012035) 1 NC_007606.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4012035 valS 3796950 valS Shigella dysenteriae Sd197 valyl-tRNA synthetase YP_405673.1 4009180 R 300267 CDS YP_405674.1 82779325 3796951 complement(4012035..4012478) 1 NC_007606.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4012478 holC 3796951 holC Shigella dysenteriae Sd197 DNA polymerase III subunit chi YP_405674.1 4012035 R 300267 CDS YP_405675.1 82779326 3796952 complement(4012736..4014247) 1 NC_007606.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4014247 pepA 3796952 pepA Shigella dysenteriae Sd197 leucyl aminopeptidase YP_405675.1 4012736 R 300267 CDS YP_405676.1 82779327 3796953 4014514..4015614 1 NC_007606.1 Code: R; COG: COG0795; hypothetical protein 4015614 yjgP 3796953 yjgP Shigella dysenteriae Sd197 hypothetical protein YP_405676.1 4014514 D 300267 CDS YP_405677.1 82779328 3796954 4015611..4016696 1 NC_007606.1 Code: R; COG: COG0795; hypothetical protein 4016696 yjgQ 3796954 yjgQ Shigella dysenteriae Sd197 hypothetical protein YP_405677.1 4015611 D 300267 CDS YP_405678.1 82779329 3796955 complement(4016857..4018359) 1 NC_007606.1 Code: R; COG: COG0433; hypothetical protein 4018359 yjgR 3796955 yjgR Shigella dysenteriae Sd197 hypothetical protein YP_405678.1 4016857 R 300267 CDS YP_405679.1 82779330 3796956 complement(4018489..4019550) 1 NC_007606.1 Code: R; COG: COG1064; oxidoreductase 4019550 yjgB 3796956 yjgB Shigella dysenteriae Sd197 oxidoreductase YP_405679.1 4018489 R 300267 CDS YP_405681.1 82779332 3799249 complement(4021038..4021340) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 4021340 3799249 SDY_4292 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_405681.1 4021038 R 300267 CDS YP_405682.1 82779333 3799250 complement(4022300..4023067) 1 NC_007606.1 Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate ABC transporter ATP-binding protein 4023067 fecE 3799250 fecE Shigella dysenteriae Sd197 iron-dicitrate ABC transporter ATP-binding protein YP_405682.1 4022300 R 300267 CDS YP_405683.1 82779334 3799251 complement(4023068..4024024) 1 NC_007606.1 ''Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.''; iron-dicitrate transporter subunit FecD 4024024 fecD 3799251 fecD Shigella dysenteriae Sd197 iron-dicitrate transporter subunit FecD YP_405683.1 4023068 R 300267 CDS YP_405684.1 82779335 3799252 complement(4024021..4025016) 1 NC_007606.1 part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate ABC transporter permease 4025016 fecC 3799252 fecC Shigella dysenteriae Sd197 iron-dicitrate ABC transporter permease YP_405684.1 4024021 R 300267 CDS YP_405685.1 82779336 3799254 complement(4025959..4028283) 1 NC_007606.1 Code: P; COG: COG4772; citrate-dependent iron transport, outer membrane receptor 4028283 fecA 3799254 fecA Shigella dysenteriae Sd197 citrate-dependent iron transport, outer membrane receptor YP_405685.1 4025959 R 300267 CDS YP_405686.1 82779337 3799256 complement(4029320..4029841) 1 NC_007606.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI 4029841 fecI 3799256 fecI Shigella dysenteriae Sd197 RNA polymerase sigma factor FecI YP_405686.1 4029320 R 300267 CDS YP_009000864.1 578793344 18263178 4029995..4030267 1 NC_007606.1 insertion element iso-IS1N protein InsA 4030267 18263178 SDY_4790 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000864.1 4029995 D 300267 CDS YP_405688.1 82779339 3799258 4030294..4030689 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4030689 3799258 SDY_4301 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405688.1 4030294 D 300267 CDS YP_405689.1 82779340 3799259 4030907..4031182 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 7 protein InsA 4031182 insA 3799259 insA Shigella dysenteriae Sd197 insertion element IS1 7 protein InsA YP_405689.1 4030907 D 300267 CDS YP_405691.1 82779342 3799261 4033358..4034731 1 NC_007606.1 hypothetical protein 4034731 3799261 SDY_4304 Shigella dysenteriae Sd197 hypothetical protein YP_405691.1 4033358 D 300267 CDS YP_405693.1 82779344 3799263 complement(4036046..4036480) 1 NC_007606.1 hypothetical protein 4036480 3799263 SDY_4306 Shigella dysenteriae Sd197 hypothetical protein YP_405693.1 4036046 R 300267 CDS YP_405694.2 161949992 3799264 complement(4036964..4037869) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4037869 3799264 SDY_4307 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405694.2 4036964 R 300267 CDS YP_405695.1 82779346 3796481 complement(4037827..4038192) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 4038192 3796481 SDY_4308 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_405695.1 4037827 R 300267 CDS YP_405696.1 82779347 3796482 4038476..4038748 1 NC_007606.1 hypothetical protein 4038748 yjbD 3796482 yjbD Shigella dysenteriae Sd197 hypothetical protein YP_405696.1 4038476 D 300267 CDS YP_405697.1 82779348 3796483 complement(4038749..4039621) 1 NC_007606.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4039621 yjbC 3796483 yjbC Shigella dysenteriae Sd197 23S rRNA pseudouridine synthase F YP_405697.1 4038749 R 300267 CDS YP_405698.1 82779349 3796484 4039969..4040916 1 NC_007606.1 Code: K; COG: COG2390; sorbose uptake and utilization genes transcriptional regulator 4040916 3796484 SDY_4311 Shigella dysenteriae Sd197 sorbose uptake and utilization genes transcriptional regulator YP_405698.1 4039969 D 300267 CDS YP_405701.1 82779352 3796488 4042122..4042919 1 NC_007606.1 Code: G; COG: COG3715; PTS system sorbose transporter subunit IIC 4042919 3796488 SDY_4315 Shigella dysenteriae Sd197 PTS system sorbose transporter subunit IIC YP_405701.1 4042122 D 300267 CDS YP_405703.1 82779354 3796490 4043805..4045034 1 NC_007606.1 Code: ER; COG: COG1063; L-sorbose 1-phosphate dehydrogenase 4045034 3796490 SDY_4317 Shigella dysenteriae Sd197 L-sorbose 1-phosphate dehydrogenase YP_405703.1 4043805 D 300267 CDS YP_405704.1 82779355 3796492 complement(4046194..4047750) 1 NC_007606.1 Code: P; COG: COG1283; alpha helix protein 4047750 yjbB 3796492 yjbB Shigella dysenteriae Sd197 alpha helix protein YP_405704.1 4046194 R 300267 CDS YP_405705.1 82779356 3796493 complement(4048081..4048458) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4048458 insB 3796493 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405705.1 4048081 R 300267 CDS YP_405706.1 82779357 3796494 complement(4048503..4048778) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4048778 insA 3796494 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405706.1 4048503 R 300267 CDS YP_405707.1 82779358 3796495 complement(4048807..4052505) 1 NC_007606.1 repressor of metE and metF; one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4052505 metH 3796495 metH Shigella dysenteriae Sd197 B12-dependent methionine synthase YP_405707.1 4048807 R 300267 CDS YP_405708.2 161949991 3796496 4052705..4053529 1 NC_007606.1 ''regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase''; IclR family transcriptional regulator 4053529 iclR 3796496 iclR Shigella dysenteriae Sd197 IclR family transcriptional regulator YP_405708.2 4052705 D 300267 CDS YP_405709.1 82779360 3796498 complement(4055288..4055683) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4055683 3796498 SDY_4325 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405709.1 4055288 R 300267 CDS YP_009000865.1 578793345 18263179 complement(4055710..4055982) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4055982 18263179 SDY_4791 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000865.1 4055710 R 300267 CDS YP_405711.1 82779362 3796500 complement(4056062..4057798) 1 NC_007606.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase 4057798 aceK 3796500 aceK Shigella dysenteriae Sd197 bifunctional isocitrate dehydrogenase kinase/phosphatase YP_405711.1 4056062 R 300267 CDS YP_405712.1 82779363 3797899 complement(4057982..4059286) 1 NC_007606.1 Code: C; COG: COG2224; isocitrate lyase 4059286 aceA 3797899 aceA Shigella dysenteriae Sd197 isocitrate lyase YP_405712.1 4057982 R 300267 CDS YP_405713.1 82779364 3797901 complement(4061145..4062074) 1 NC_007606.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4062074 metA 3797901 metA Shigella dysenteriae Sd197 homoserine O-succinyltransferase YP_405713.1 4061145 R 300267 CDS YP_405714.1 82779365 3797902 complement(4062208..4062585) 1 NC_007606.1 Code: L; COG: COG1662; insertion sequence element IS1 transposase 4062585 insB 3797902 insB Shigella dysenteriae Sd197 insertion sequence element IS1 transposase YP_405714.1 4062208 R 300267 CDS YP_405715.1 82779366 3797903 complement(4062630..4062905) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4062905 insA 3797903 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405715.1 4062630 R 300267 CDS YP_405716.1 82779367 3797904 4063007..4063450 1 NC_007606.1 Code: KR; COG: COG0454; hypothetical protein 4063450 yjaB 3797904 yjaB Shigella dysenteriae Sd197 hypothetical protein YP_405716.1 4063007 D 300267 CDS YP_405717.1 82779368 3797905 complement(4063514..4063897) 1 NC_007606.1 hypothetical protein 4063897 yjaA 3797905 yjaA Shigella dysenteriae Sd197 hypothetical protein YP_405717.1 4063514 R 300267 CDS YP_405718.1 82779369 3797906 4064021..4065367 1 NC_007606.1 Code: L; COG: COG3385; insertion sequence element IS4 transposase InsG 4065367 3797906 SDY_4335 Shigella dysenteriae Sd197 insertion sequence element IS4 transposase InsG YP_405718.1 4064021 D 300267 CDS YP_009000866.1 578793346 18263180 4065894..4066166 1 NC_007606.1 insertion element iso-IS1N protein InsA 4066166 18263180 SDY_4792 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000866.1 4065894 D 300267 CDS YP_405719.1 82779370 3797908 4066193..4066540 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4066540 3797908 SDY_4337 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405719.1 4066193 D 300267 CDS YP_405720.1 82779371 3797909 4066574..4066849 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4066849 insA 3797909 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405720.1 4066574 D 300267 CDS YP_405721.1 82779372 3797910 4066894..4067271 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4067271 insB 3797910 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405721.1 4066894 D 300267 CDS YP_405722.1 82779373 3797911 complement(4067282..4068280) 1 NC_007606.1 Code: S; COG: COG3274; hypothetical protein 4068280 yiaH 3797911 yiaH Shigella dysenteriae Sd197 hypothetical protein YP_405722.1 4067282 R 300267 CDS YP_405723.1 82779374 3797912 4068418..4068720 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 4068720 3797912 SDY_4341 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_405723.1 4068418 D 300267 CDS YP_405724.1 82779375 3797913 4068861..4069691 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4069691 3797913 SDY_4342 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_405724.1 4068861 D 300267 CDS YP_405725.1 82779376 3797914 4069724..4070023 1 NC_007606.1 hypothetical protein 4070023 3797914 SDY_4343 Shigella dysenteriae Sd197 hypothetical protein YP_405725.1 4069724 D 300267 CDS YP_405726.1 82779377 3797915 4070118..4071029 1 NC_007606.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4071029 glyQ 3797915 glyQ Shigella dysenteriae Sd197 glycyl-tRNA synthetase subunit alpha YP_405726.1 4070118 D 300267 CDS YP_405727.1 82779378 3797916 4071039..4073108 1 NC_007606.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4073108 glyS 3797916 glyS Shigella dysenteriae Sd197 glycyl-tRNA synthetase subunit beta YP_405727.1 4071039 D 300267 CDS YP_405728.1 82779379 3797917 4073431..4073583 1 NC_007606.1 small toxic polypeptide 4073583 yiaZ 3797917 yiaZ Shigella dysenteriae Sd197 small toxic polypeptide YP_405728.1 4073431 D 300267 CDS YP_405729.1 82779380 3798157 complement(4073771..4073983) 1 NC_007606.1 transcriptional activator of hns; Code: K; COG: COG1278; cold-shock protein 4073983 cspA 3798157 cspA Shigella dysenteriae Sd197 cold-shock protein YP_405729.1 4073771 R 300267 CDS YP_405730.1 82779381 3798158 complement(4074264..4074554) 1 NC_007606.1 Code: K; COG: COG2944; transcriptional regulator 4074554 yiaG 3798158 yiaG Shigella dysenteriae Sd197 transcriptional regulator YP_405730.1 4074264 R 300267 CDS YP_405731.1 82779382 3798159 4074812..4075642 1 NC_007606.1 hypothetical protein 4075642 yiaF 3798159 yiaF Shigella dysenteriae Sd197 hypothetical protein YP_405731.1 4074812 D 300267 CDS YP_405732.2 161949990 3798160 complement(4075692..4076666) 1 NC_007606.1 Code: CHR; COG: COG1052; dehydrogenase 4076666 yiaE 3798160 yiaE Shigella dysenteriae Sd197 dehydrogenase YP_405732.2 4075692 R 300267 CDS YP_405733.1 82779384 3798162 4077283..4079502 1 NC_007606.1 Code: C; COG: COG0243; biotin sulfoxide reductase 4079502 bisC 3798162 bisC Shigella dysenteriae Sd197 biotin sulfoxide reductase YP_405733.1 4077283 D 300267 CDS YP_405734.1 82779385 3798163 complement(4079908..4080471) 1 NC_007606.1 ''constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine''; 3-methyladenine DNA glycosylase 4080471 tag 3798163 tag Shigella dysenteriae Sd197 3-methyladenine DNA glycosylase YP_405734.1 4079908 R 300267 CDS YP_009000867.1 578793347 18263181 4082831..4083103 1 NC_007606.1 insertion element iso-IS1N protein InsA 4083103 18263181 SDY_4793 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000867.1 4082831 D 300267 CDS YP_405736.1 82779387 3798166 4083130..4083525 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 4083525 3798166 SDY_4356 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405736.1 4083130 D 300267 CDS YP_405737.1 82779388 3798167 complement(4083607..4083909) 1 NC_007606.1 hypothetical protein 4083909 yjfN 3798167 yjfN Shigella dysenteriae Sd197 hypothetical protein YP_405737.1 4083607 R 300267 CDS YP_405738.2 161949989 3798168 complement(4084031..4084360) 1 NC_007606.1 hypothetical protein 4084360 yjfO 3798168 yjfO Shigella dysenteriae Sd197 hypothetical protein YP_405738.2 4084031 R 300267 CDS YP_405739.1 82779390 3798169 4084542..4085291 1 NC_007606.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4085291 yjfP 3798169 yjfP Shigella dysenteriae Sd197 esterase YP_405739.1 4084542 D 300267 CDS YP_405740.1 82779391 3798170 complement(4085288..4086043) 1 NC_007606.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4086043 yjfQ 3798170 yjfQ Shigella dysenteriae Sd197 transcriptional repressor UlaR YP_405740.1 4085288 R 300267 CDS YP_405742.2 161949988 3798172 4087560..4088957 1 NC_007606.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4088957 ulaA 3798172 ulaA Shigella dysenteriae Sd197 PTS system ascorbate-specific transporter subunit IIC YP_405742.2 4087560 D 300267 CDS YP_405743.1 82779394 3798173 4088973..4089278 1 NC_007606.1 Code: G; COG: COG3414; PTS system L-ascorbate-specific transporter subunit IIB 4089278 sgaB 3798173 sgaB Shigella dysenteriae Sd197 PTS system L-ascorbate-specific transporter subunit IIB YP_405743.1 4088973 D 300267 CDS YP_405744.1 82779395 3798174 4089288..4089752 1 NC_007606.1 Code: GT; COG: COG1762; PTS system L-ascorbate-specific transporter subunit IIA 4089752 ptxA 3798174 ptxA Shigella dysenteriae Sd197 PTS system L-ascorbate-specific transporter subunit IIA YP_405744.1 4089288 D 300267 CDS YP_405745.1 82779396 3798175 4089766..4090416 1 NC_007606.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4090416 ulaD 3798175 ulaD Shigella dysenteriae Sd197 3-keto-L-gulonate-6-phosphate decarboxylase YP_405745.1 4089766 D 300267 CDS YP_405746.1 82779397 3797690 4091280..4091966 1 NC_007606.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4091966 sgaE 3797690 sgaE Shigella dysenteriae Sd197 L-ribulose-5-phosphate 4-epimerase YP_405746.1 4091280 D 300267 CDS YP_405747.1 82779398 3797692 4092697..4093092 1 NC_007606.1 ''binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21''; 30S ribosomal protein S6 4093092 rpsF 3797692 rpsF Shigella dysenteriae Sd197 30S ribosomal protein S6 YP_405747.1 4092697 D 300267 CDS YP_405748.1 82779399 3797693 4093099..4093413 1 NC_007606.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4093413 priB 3797693 priB Shigella dysenteriae Sd197 primosomal replication protein N YP_405748.1 4093099 D 300267 CDS YP_405749.1 82779400 3797694 4093418..4093645 1 NC_007606.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4093645 rpsR 3797694 rpsR Shigella dysenteriae Sd197 30S ribosomal protein S18 YP_405749.1 4093418 D 300267 CDS YP_405750.1 82779401 3797695 4093687..4094136 1 NC_007606.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4094136 rplI 3797695 rplI Shigella dysenteriae Sd197 50S ribosomal protein L9 YP_405750.1 4093687 D 300267 CDS YP_405751.1 82779402 3797696 complement(4095003..4095398) 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 4095398 3797696 SDY_4373 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405751.1 4095003 R 300267 CDS YP_009000868.1 578793348 18263182 complement(4095425..4095697) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4095697 18263182 SDY_4794 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000868.1 4095425 R 300267 CDS YP_405752.1 82779403 3797697 4095834..4096109 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4096109 insA 3797697 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405752.1 4095834 D 300267 CDS YP_405753.1 82779404 3797698 4096154..4096531 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4096531 insB 3797698 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405753.1 4096154 D 300267 CDS YP_405754.1 82779405 3797699 complement(4096641..4097315) 1 NC_007606.1 Code: M; COG: COG3061; hypothetical protein 4097315 ytfB 3797699 ytfB Shigella dysenteriae Sd197 hypothetical protein YP_405754.1 4096641 R 300267 CDS YP_405755.2 161949987 3797700 4097497..4098117 1 NC_007606.1 rotamase; FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4098117 fklB 3797700 fklB Shigella dysenteriae Sd197 peptidyl-prolyl cis-trans isomerase YP_405755.2 4097497 D 300267 CDS YP_405756.1 82779407 3797701 4098426..4099838 1 NC_007606.1 ''involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine''; D-alanine/D-serine/glycine permease 4099838 cycA 3797701 cycA Shigella dysenteriae Sd197 D-alanine/D-serine/glycine permease YP_405756.1 4098426 D 300267 CDS YP_405757.1 82779408 3797702 complement(4099883..4100545) 1 NC_007606.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4100545 ytfE 3797702 ytfE Shigella dysenteriae Sd197 iron-sulfur cluster repair di-iron protein YP_405757.1 4099883 R 300267 CDS YP_405758.1 82779409 3797703 complement(4100648..4101622) 1 NC_007606.1 Code: GER; COG: COG0697; transmembrane subunit 4101622 ytfF 3797703 ytfF Shigella dysenteriae Sd197 transmembrane subunit YP_405758.1 4100648 R 300267 CDS YP_405759.1 82779411 3797705 complement(4101721..4102581) 1 NC_007606.1 Code: MG; COG: COG0702; oxidoreductase 4102581 ytfG 3797705 ytfG Shigella dysenteriae Sd197 oxidoreductase YP_405759.1 4101721 R 300267 CDS YP_405760.1 82779410 3797704 4102580..4103050 1 NC_007606.1 Code: K; COG: COG1733; hypothetical protein 4103050 ytfH 3797704 ytfH Shigella dysenteriae Sd197 hypothetical protein YP_405760.1 4102580 D 300267 CDS YP_405761.1 82779412 3797706 complement(4103167..4105116) 1 NC_007606.1 ''periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate''; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4105116 cpdB 3797706 cpdB Shigella dysenteriae Sd197 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_405761.1 4103167 R 300267 CDS YP_405762.1 82779413 3797707 complement(4105117..4105512) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4105512 3797707 SDY_4384 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405762.1 4105117 R 300267 CDS YP_009000869.1 578793349 18263183 complement(4105539..4105811) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4105811 18263183 SDY_4795 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000869.1 4105539 R 300267 CDS YP_405763.1 82779414 3797708 4106074..4106814 1 NC_007606.1 affects pool of 3'-phosphoadenosine-5'-phosphosulfate in pathway of sulfite synthesis; ''catalyzes the formation of AMP from adenosine-3',5'-bisphosphate''; adenosine-3'(2'),5'-bisphosphate nucleotidase 4106814 cysQ 3797708 cysQ Shigella dysenteriae Sd197 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_405763.1 4106074 D 300267 CDS YP_405764.1 82779415 3798197 complement(4107001..4107378) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4107378 insB 3798197 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405764.1 4107001 R 300267 CDS YP_405765.1 82779416 3798198 complement(4107423..4107698) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4107698 insA 3798198 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405765.1 4107423 R 300267 CDS YP_405766.1 82779417 3798199 complement(4107769..4108164) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4108164 3798199 SDY_4388 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405766.1 4107769 R 300267 CDS YP_009000870.1 578793350 18263184 complement(4108191..4108463) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4108463 18263184 SDY_4796 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000870.1 4108191 R 300267 CDS YP_405767.1 82779418 3798200 complement(4108569..4109597) 1 NC_007606.1 Code: E; COG: COG1509; hypothetical protein 4109597 yjeK 3798200 yjeK Shigella dysenteriae Sd197 hypothetical protein YP_405767.1 4108569 R 300267 CDS YP_405768.1 82779419 3798201 4109639..4110205 1 NC_007606.1 EF-P; Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4110205 efp 3798201 efp Shigella dysenteriae Sd197 elongation factor P YP_405768.1 4109639 D 300267 CDS YP_405769.1 82779420 3798202 4110257..4110382 1 NC_007606.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4110382 3798202 SDY_4391 Shigella dysenteriae Sd197 entericidin A YP_405769.1 4110257 D 300267 CDS YP_405770.2 578793351 3798203 4110815..4111132 1 NC_007606.1 suppresses groEL, may be chaperone; Code: P; COG: COG2076; SugE protein 4111132 sugE 3798203 sugE Shigella dysenteriae Sd197 SugE protein YP_405770.2 4110815 D 300267 CDS YP_405771.1 82779422 3798204 complement(4111129..4111662) 1 NC_007606.1 lipocalin; lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4111662 blc 3798204 blc Shigella dysenteriae Sd197 outer membrane lipoprotein Blc YP_405771.1 4111129 R 300267 CDS YP_405772.1 82779423 3798205 complement(4111751..4112884) 1 NC_007606.1 penicillin resistance; Code: V; COG: COG1680; beta-lactamase 4112884 ampC 3798205 ampC Shigella dysenteriae Sd197 beta-lactamase YP_405772.1 4111751 R 300267 CDS YP_405773.1 82779424 3798206 complement(4112947..4113306) 1 NC_007606.1 membrane anchor polypeptide; in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4113306 frdD 3798206 frdD Shigella dysenteriae Sd197 fumarate reductase subunit D YP_405773.1 4112947 R 300267 CDS YP_405774.1 82779425 3798207 complement(4113317..4113712) 1 NC_007606.1 membrane anchor polypeptide; ''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''; fumarate reductase subunit C 4113712 frdC 3798207 frdC Shigella dysenteriae Sd197 fumarate reductase subunit C YP_405774.1 4113317 R 300267 CDS YP_405775.1 82779426 3798208 complement(4113723..4114457) 1 NC_007606.1 ''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''; fumarate reductase iron-sulfur subunit 4114457 frdB 3798208 frdB Shigella dysenteriae Sd197 fumarate reductase iron-sulfur subunit YP_405775.1 4113723 R 300267 CDS YP_405776.1 82779427 3798209 complement(4114450..4116258) 1 NC_007606.1 ''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''; fumarate reductase flavoprotein subunit 4116258 frdA 3798209 frdA Shigella dysenteriae Sd197 fumarate reductase flavoprotein subunit YP_405776.1 4114450 R 300267 CDS YP_405777.2 161949986 3798210 4116583..4117560 1 NC_007606.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4117560 yjeA 3798210 yjeA Shigella dysenteriae Sd197 lysyl-tRNA synthetase YP_405777.2 4116583 D 300267 CDS YP_009000871.1 578793352 18263185 complement(4118239..4118511) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4118511 18263185 SDY_4797 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000871.1 4118239 R 300267 CDS YP_405780.1 82779431 3798213 4118639..4119277 1 NC_007606.1 Code: S; COG: COG5463; hypothetical protein 4119277 yjfM 3798213 yjfM Shigella dysenteriae Sd197 hypothetical protein YP_405780.1 4118639 D 300267 CDS YP_405781.1 82779432 3798214 4119280..4120443 1 NC_007606.1 Code: E; COG: COG0754; synthetase/amidase 4120443 yjfC 3798214 yjfC Shigella dysenteriae Sd197 synthetase/amidase YP_405781.1 4119280 D 300267 CDS YP_405782.1 82779433 3798215 4120512..4122140 1 NC_007606.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4122140 aidB 3798215 aidB Shigella dysenteriae Sd197 isovaleryl CoA dehydrogenase YP_405782.1 4120512 D 300267 CDS YP_009000872.1 578793353 18263186 4122255..4122527 1 NC_007606.1 insertion element iso-IS1N protein InsA 4122527 18263186 SDY_4798 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000872.1 4122255 D 300267 CDS YP_405784.1 82779435 3797368 4122554..4122949 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4122949 3797368 SDY_4406 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405784.1 4122554 D 300267 CDS YP_405785.1 82779436 3797369 4123058..4123333 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4123333 insA 3797369 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405785.1 4123058 D 300267 CDS YP_405786.1 82779437 3797370 4123378..4123755 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4123755 insB 3797370 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405786.1 4123378 D 300267 CDS YP_405787.1 82779438 3797371 complement(4123832..4124563) 1 NC_007606.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4124563 yjfH 3797371 yjfH Shigella dysenteriae Sd197 23S rRNA (guanosine-2'-O-)-methyltransferase YP_405787.1 4123832 R 300267 CDS YP_405788.2 161949985 3797372 complement(4124744..4127173) 1 NC_007606.1 ''3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs''; exoribonuclease R 4127173 vacB 3797372 vacB Shigella dysenteriae Sd197 exoribonuclease R YP_405788.2 4124744 R 300267 CDS YP_405789.1 82779440 3797373 complement(4127212..4127637) 1 NC_007606.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4127637 yjeB 3797373 yjeB Shigella dysenteriae Sd197 transcriptional repressor NsrR YP_405789.1 4127212 R 300267 CDS YP_405790.1 82779441 3797374 complement(4127842..4129140) 1 NC_007606.1 ''catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis''; adenylosuccinate synthetase 4129140 purA 3797374 purA Shigella dysenteriae Sd197 adenylosuccinate synthetase YP_405790.1 4127842 R 300267 CDS YP_405791.1 82779442 3797375 complement(4129244..4129441) 1 NC_007606.1 Code: S; COG: COG3242; hypothetical protein 4129441 yjeT 3797375 yjeT Shigella dysenteriae Sd197 hypothetical protein YP_405791.1 4129244 R 300267 CDS YP_405792.1 82779443 3797376 complement(4129523..4130527) 1 NC_007606.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4130527 hflC 3797376 hflC Shigella dysenteriae Sd197 FtsH protease regulator HflC YP_405792.1 4129523 R 300267 CDS YP_405793.1 82779444 3797377 complement(4130530..4131789) 1 NC_007606.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4131789 hflK 3797377 hflK Shigella dysenteriae Sd197 FtsH protease regulator HflK YP_405793.1 4130530 R 300267 CDS YP_405794.1 82779445 3797378 complement(4131875..4133155) 1 NC_007606.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4133155 hflX 3797378 hflX Shigella dysenteriae Sd197 GTPase HflX YP_405794.1 4131875 R 300267 CDS YP_405795.1 82779446 3797379 complement(4133231..4133539) 1 NC_007606.1 a growth-related protein; Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4133539 hfq 3797379 hfq Shigella dysenteriae Sd197 RNA-binding protein Hfq YP_405795.1 4133231 R 300267 CDS YP_405796.1 82779447 3797380 complement(4133625..4134575) 1 NC_007606.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4134575 miaA 3797380 miaA Shigella dysenteriae Sd197 tRNA delta(2)-isopentenylpyrophosphate transferase YP_405796.1 4133625 R 300267 CDS YP_405797.1 82779448 3797381 complement(4134568..4136415) 1 NC_007606.1 enzyme in methyl-directed mismatch repair; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4136415 mutL 3797381 mutL Shigella dysenteriae Sd197 DNA mismatch repair protein YP_405797.1 4134568 R 300267 CDS YP_405798.1 82779449 3797382 complement(4136425..4137762) 1 NC_007606.1 a murein hydrolase; Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase 4137762 amiB 3797382 amiB Shigella dysenteriae Sd197 N-acetylmuramoyl-L-alanine amidase YP_405798.1 4136425 R 300267 CDS YP_405799.1 82779450 3797383 complement(4137781..4138242) 1 NC_007606.1 possibly involved in cell wall synthesis; ATPase 4138242 yjeE 3797383 yjeE Shigella dysenteriae Sd197 ATPase YP_405799.1 4137781 R 300267 CDS YP_405800.1 82779451 3797384 complement(4139419..4139814) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4139814 3797384 SDY_4422 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405800.1 4139419 R 300267 CDS YP_009000873.1 578793354 18263187 complement(4139841..4140113) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4140113 18263187 SDY_4799 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000873.1 4139841 R 300267 CDS YP_405802.1 82779453 3797386 complement(4140193..4140588) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4140588 3797386 SDY_4424 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405802.1 4140193 R 300267 CDS YP_009000874.1 578793355 18263188 complement(4140615..4140887) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4140887 18263188 SDY_4800 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000874.1 4140615 R 300267 CDS YP_405803.1 82779454 3797353 4141308..4142447 1 NC_007606.1 Code: C; COG: COG1600; hypothetical protein 4142447 yjeS 3797353 yjeS Shigella dysenteriae Sd197 hypothetical protein YP_405803.1 4141308 D 300267 CDS YP_405804.2 161949984 3797358 complement(4143225..4143770) 1 NC_007606.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4143770 yjeR 3797358 yjeR Shigella dysenteriae Sd197 oligoribonuclease YP_405804.2 4143225 R 300267 CDS YP_405805.2 161949983 3797359 4143865..4144917 1 NC_007606.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4144917 yjeQ 3797359 yjeQ Shigella dysenteriae Sd197 ribosome-associated GTPase YP_405805.2 4143865 D 300267 CDS YP_405806.1 82779457 3797360 4145014..4145982 1 NC_007606.1 phospholipid synthesis; catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4145982 psd 3797360 psd Shigella dysenteriae Sd197 phosphatidylserine decarboxylase YP_405806.1 4145014 D 300267 CDS YP_405807.1 82779458 3797361 4146004..4149327 1 NC_007606.1 Code: M; COG: COG3264; hypothetical protein 4149327 yjeP 3797361 yjeP Shigella dysenteriae Sd197 hypothetical protein YP_405807.1 4146004 D 300267 CDS YP_405808.1 82779459 3797362 complement(4149478..4150959) 1 NC_007606.1 Code: E; COG: COG0531; transporter 4150959 yjeM 3797362 yjeM Shigella dysenteriae Sd197 transporter YP_405808.1 4149478 R 300267 CDS YP_405809.1 82779460 3797363 complement(4150980..4151375) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4151375 3797363 SDY_4435 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405809.1 4150980 R 300267 CDS YP_009000875.1 578793356 18263189 complement(4151402..4151674) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4151674 18263189 SDY_4801 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000875.1 4151402 R 300267 CDS YP_405811.1 82779462 3797365 complement(4151918..4152295) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4152295 insB 3797365 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405811.1 4151918 R 300267 CDS YP_405812.1 82779463 3797366 complement(4152340..4152615) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4152615 insA 3797366 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405812.1 4152340 R 300267 CDS YP_405814.1 82779465 3798332 complement(4154160..4155857) 1 NC_007606.1 copper tolerance; two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4155857 dipZ 3798332 dipZ Shigella dysenteriae Sd197 thiol:disulfide interchange protein YP_405814.1 4154160 R 300267 CDS YP_405815.1 82779466 3798333 complement(4155833..4156171) 1 NC_007606.1 cytochrome c biogenesis; copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4156171 cutA 3798333 cutA Shigella dysenteriae Sd197 divalent-cation tolerance protein CutA YP_405815.1 4155833 R 300267 CDS YP_405816.1 82779467 3798334 complement(4156287..4157588) 1 NC_007606.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4157588 dcuA 3798334 dcuA Shigella dysenteriae Sd197 anaerobic C4-dicarboxylate transporter YP_405816.1 4156287 R 300267 CDS YP_405817.1 82779468 3798335 complement(4157706..4159187) 1 NC_007606.1 aspartase; catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4159187 aspA 3798335 aspA Shigella dysenteriae Sd197 aspartate ammonia-lyase YP_405817.1 4157706 R 300267 CDS YP_405818.1 82779469 3798336 4159478..4159954 1 NC_007606.1 Protein affecting phage T7 exclusion by the F plasmid; F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4159954 fxsA 3798336 fxsA Shigella dysenteriae Sd197 FxsA protein YP_405818.1 4159478 D 300267 CDS YP_405819.1 82779470 3798337 complement(4160023..4160418) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4160418 3798337 SDY_4446 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405819.1 4160023 R 300267 CDS YP_009000876.1 578793357 18263190 complement(4160445..4160717) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4160717 18263190 SDY_4802 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000876.1 4160445 R 300267 CDS YP_405820.1 82779471 3798338 complement(4160753..4162000) 1 NC_007606.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein 4162000 yjeH 3798338 yjeH Shigella dysenteriae Sd197 hypothetical protein YP_405820.1 4160753 R 300267 CDS YP_405821.1 82779472 3798339 4162276..4162569 1 NC_007606.1 10 kDa chaperone binds to Hsp60 in pres. Mg-ATP, suppressing its ATPase activity; 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4162569 groES 3798339 groES Shigella dysenteriae Sd197 co-chaperonin GroES YP_405821.1 4162276 D 300267 CDS YP_405822.1 82779473 3798340 4162613..4164259 1 NC_007606.1 chaperone Hsp60, peptide-dependent ATPase, heat shock protein; ''60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth''; molecular chaperone GroEL 4164259 groEL 3798340 groEL Shigella dysenteriae Sd197 molecular chaperone GroEL YP_405822.1 4162613 D 300267 CDS YP_405823.1 82779474 3798341 4164364..4164750 1 NC_007606.1 hypothetical protein 4164750 yjeI 3798341 yjeI Shigella dysenteriae Sd197 hypothetical protein YP_405823.1 4164364 D 300267 CDS YP_009000877.1 578793358 18263191 4165174..4165446 1 NC_007606.1 insertion element iso-IS1N protein InsA 4165446 18263191 SDY_4803 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000877.1 4165174 D 300267 CDS YP_405824.1 82779475 3798343 4165473..4165868 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 4165868 3798343 SDY_4452 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405824.1 4165473 D 300267 CDS YP_405825.1 82779476 3798344 complement(4166304..4166858) 1 NC_007606.1 Code: R; COG: COG3054; hypothetical protein 4166858 ytfJ 3798344 ytfJ Shigella dysenteriae Sd197 hypothetical protein YP_405825.1 4166304 R 300267 CDS YP_405826.1 82779477 3798345 4167144..4167389 1 NC_007606.1 hypothetical protein 4167389 ytfK 3798345 ytfK Shigella dysenteriae Sd197 hypothetical protein YP_405826.1 4167144 D 300267 CDS YP_405827.1 82779478 3798346 complement(4167468..4168811) 1 NC_007606.1 Code: R; COG: COG1253; transport protein 4168811 ytfL 3798346 ytfL Shigella dysenteriae Sd197 transport protein YP_405827.1 4167468 R 300267 CDS YP_405828.1 82779479 3798347 complement(4169134..4169772) 1 NC_007606.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4169772 msrA 3798347 msrA Shigella dysenteriae Sd197 methionine sulfoxide reductase A YP_405828.1 4169134 R 300267 CDS YP_405829.1 82779480 3798348 4169978..4171711 1 NC_007606.1 Code: M; COG: COG0729; hypothetical protein 4171711 ytfM 3798348 ytfM Shigella dysenteriae Sd197 hypothetical protein YP_405829.1 4169978 D 300267 CDS YP_405830.1 82779481 3797519 4171708..4175487 1 NC_007606.1 Code: S; COG: COG2911; hypothetical protein 4175487 ytfN 3797519 ytfN Shigella dysenteriae Sd197 hypothetical protein YP_405830.1 4171708 D 300267 CDS YP_405831.1 82779482 3797520 4175490..4175831 1 NC_007606.1 Code: S; COG: COG2105; hypothetical protein 4175831 ytfP 3797520 ytfP Shigella dysenteriae Sd197 hypothetical protein YP_405831.1 4175490 D 300267 CDS YP_405832.1 82779483 3797521 4176037..4176294 1 NC_007606.1 part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4176294 chpS 3797521 chpS Shigella dysenteriae Sd197 antitoxin ChpS YP_405832.1 4176037 D 300267 CDS YP_405833.1 82779484 3797522 4176288..4176638 1 NC_007606.1 toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4176638 chpB 3797522 chpB Shigella dysenteriae Sd197 toxin ChpB YP_405833.1 4176288 D 300267 CDS YP_405834.1 82779485 3797523 complement(4176715..4177245) 1 NC_007606.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4177245 ppa 3797523 ppa Shigella dysenteriae Sd197 inorganic pyrophosphatase YP_405834.1 4176715 R 300267 CDS YP_405835.1 82779486 3797525 complement(4178069..4178464) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4178464 3797525 SDY_4464 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405835.1 4178069 R 300267 CDS YP_009000878.1 578793359 18263192 complement(4178491..4178763) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4178763 18263192 SDY_4804 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000878.1 4178491 R 300267 CDS YP_405836.1 82779487 3797528 4182188..4183645 1 NC_007606.1 Code: E; COG: COG3104; peptide transporter 4183645 yjdL 3797528 yjdL Shigella dysenteriae Sd197 peptide transporter YP_405836.1 4182188 D 300267 CDS YP_405837.1 82779488 3797530 complement(4184098..4184811) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4184811 3797530 SDY_4469 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_405837.1 4184098 R 300267 CDS YP_405838.1 82779489 3797531 4185270..4186106 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS911 integrase core domain-containing protein 4186106 3797531 SDY_4470 Shigella dysenteriae Sd197 insertion sequence element IS911 integrase core domain-containing protein YP_405838.1 4185270 D 300267 CDS YP_009000879.1 578793360 18263193 4188024..4188296 1 NC_007606.1 insertion element iso-IS1N protein InsA 4188296 18263193 SDY_4805 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000879.1 4188024 D 300267 CDS YP_405840.1 82779491 3797534 4188323..4188718 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 4188718 3797534 SDY_4473 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405840.1 4188323 D 300267 CDS YP_405841.1 82779492 3797535 4188742..4189452 1 NC_007606.1 Code: L; COG: COG3328; transposase 4189452 3797535 SDY_4474 Shigella dysenteriae Sd197 transposase YP_405841.1 4188742 D 300267 CDS YP_009000880.1 578793361 18263194 4190220..4190492 1 NC_007606.1 insertion element iso-IS1N protein InsA 4190492 18263194 SDY_4806 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000880.1 4190220 D 300267 CDS YP_405843.1 82779494 3797537 4190519..4190914 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4190914 3797537 SDY_4476 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405843.1 4190519 D 300267 CDS YP_405844.1 82779495 3798599 4191566..4192180 1 NC_007606.1 sensor EvgS; ''response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance''; DNA-binding transcriptional activator EvgA 4192180 evgA 3798599 evgA Shigella dysenteriae Sd197 DNA-binding transcriptional activator EvgA YP_405844.1 4191566 D 300267 CDS YP_405845.1 82779496 3798600 4192185..4195778 1 NC_007606.1 Code: ET; COG: COG0834; hybrid sensory histidine kinase in two-component regulatory system with EvgA 4195778 evgS 3798600 evgS Shigella dysenteriae Sd197 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_405845.1 4192185 D 300267 CDS YP_405846.1 82779497 3798601 complement(4195938..4197476) 1 NC_007606.1 Code: L; COG: COG3436; insertion sequence element ISSfl4 transposase 4197476 3798601 SDY_4479 Shigella dysenteriae Sd197 insertion sequence element ISSfl4 transposase YP_405846.1 4195938 R 300267 CDS YP_405847.1 82779498 3798602 complement(4197526..4197873) 1 NC_007606.1 Code: L; COG: COG3436; insertion sequence element ISSfl4 ORF2 4197873 3798602 SDY_4480 Shigella dysenteriae Sd197 insertion sequence element ISSfl4 ORF2 YP_405847.1 4197526 R 300267 CDS YP_405848.1 82779499 3798603 4198920..4199255 1 NC_007606.1 Code: L; COG: COG3436; insertion sequence element ISSfl4 ORF2 4199255 3798603 SDY_4481 Shigella dysenteriae Sd197 insertion sequence element ISSfl4 ORF2 YP_405848.1 4198920 D 300267 CDS YP_405849.1 82779500 3798604 4199275..4199685 1 NC_007606.1 hypothetical protein 4199685 3798604 SDY_4482 Shigella dysenteriae Sd197 hypothetical protein YP_405849.1 4199275 D 300267 CDS YP_405850.1 82779501 3798605 4199817..4200092 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4200092 insA 3798605 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405850.1 4199817 D 300267 CDS YP_405851.1 82779502 3798606 4200137..4200514 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4200514 insB 3798606 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405851.1 4200137 D 300267 CDS YP_405852.1 82779503 3798607 4200709..4201422 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4201422 3798607 SDY_4485 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_405852.1 4200709 D 300267 CDS YP_405853.1 82779504 3798608 complement(4201419..4201622) 1 NC_007606.1 hypothetical protein 4201622 3798608 SDY_4486 Shigella dysenteriae Sd197 hypothetical protein YP_405853.1 4201419 R 300267 CDS YP_009000881.1 578793362 18263195 4202174..4202446 1 NC_007606.1 insertion element iso-IS1N protein InsA 4202446 18263195 SDY_4807 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000881.1 4202174 D 300267 CDS YP_405854.1 82779505 3798609 4202473..4202868 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4202868 3798609 SDY_4487 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405854.1 4202473 D 300267 CDS YP_405855.1 82779506 3798610 complement(4202980..4203927) 1 NC_007606.1 hypothetical protein 4203927 3798610 SDY_4488 Shigella dysenteriae Sd197 hypothetical protein YP_405855.1 4202980 R 300267 CDS YP_405856.1 82779507 3798611 complement(4204174..4204569) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4204569 3798611 SDY_4489 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405856.1 4204174 R 300267 CDS YP_009000882.1 578793363 18263196 complement(4204596..4204868) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4204868 18263196 SDY_4808 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000882.1 4204596 R 300267 CDS YP_405857.1 82779508 3798612 complement(4205317..4206093) 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4206093 3798612 SDY_4490 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_405857.1 4205317 R 300267 CDS YP_405858.1 82779509 3798613 complement(4206234..4206536) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 4206536 3798613 SDY_4491 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_405858.1 4206234 R 300267 CDS YP_405859.1 82779510 3798614 4206637..4206981 1 NC_007606.1 hypothetical protein 4206981 3798614 SDY_4492 Shigella dysenteriae Sd197 hypothetical protein YP_405859.1 4206637 D 300267 CDS YP_405862.1 82779513 3798617 complement(4207854..4208156) 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS911 transposase InsN 4208156 3798617 SDY_4495 Shigella dysenteriae Sd197 insertion sequence element IS911 transposase InsN YP_405862.1 4207854 R 300267 CDS YP_009000883.1 578793364 18263197 4208255..4208527 1 NC_007606.1 insertion element iso-IS1N protein InsA 4208527 18263197 SDY_4809 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000883.1 4208255 D 300267 CDS YP_405863.1 82779514 3798637 4208554..4208949 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 4208949 3798637 SDY_4496 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405863.1 4208554 D 300267 CDS YP_405864.1 82779515 3798639 4210361..4211284 1 NC_007606.1 Code: GER; COG: COG0697; permease 4211284 yicL 3798639 yicL Shigella dysenteriae Sd197 permease YP_405864.1 4210361 D 300267 CDS YP_405865.1 82779516 3798640 complement(4211288..4212106) 1 NC_007606.1 Code: P; COG: COG1464; hypothetical protein 4212106 nlpA 3798640 nlpA Shigella dysenteriae Sd197 hypothetical protein YP_405865.1 4211288 R 300267 CDS YP_405866.1 82779517 3798641 complement(4212189..4212566) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4212566 insB 3798641 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405866.1 4212189 R 300267 CDS YP_405867.1 82779518 3798642 complement(4212611..4212886) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4212886 insA 3798642 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405867.1 4212611 R 300267 CDS YP_405868.1 82779519 3798643 complement(4213119..4214768) 1 NC_007606.1 Code: P; COG: COG0025; hypothetical protein 4214768 yjcE 3798643 yjcE Shigella dysenteriae Sd197 hypothetical protein YP_405868.1 4213119 R 300267 CDS YP_405869.1 82779520 3798644 complement(4214919..4216268) 1 NC_007606.1 Code: R; COG: COG2252; hypothetical protein 4216268 yjcD 3798644 yjcD Shigella dysenteriae Sd197 hypothetical protein YP_405869.1 4214919 R 300267 CDS YP_405870.1 82779521 3798645 complement(4216815..4217279) 1 NC_007606.1 Code: K; COG: COG0789; redox-sensing activator of soxS 4217279 soxR 3798645 soxR Shigella dysenteriae Sd197 redox-sensing activator of soxS YP_405870.1 4216815 R 300267 CDS YP_405871.1 82779522 3798646 4217365..4217688 1 NC_007606.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4217688 soxS 3798646 soxS Shigella dysenteriae Sd197 DNA-binding transcriptional regulator SoxS YP_405871.1 4217365 D 300267 CDS YP_009000884.1 578793365 18263198 4217957..4218229 1 NC_007606.1 insertion element iso-IS1N protein InsA 4218229 18263198 SDY_4810 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000884.1 4217957 D 300267 CDS YP_405872.1 82779523 3798647 4218256..4218651 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 4218651 3798647 SDY_4506 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405872.1 4218256 D 300267 CDS YP_405873.2 578793366 3798648 4219013..4219294 1 NC_007606.1 hypothetical protein 4219294 yjcB 3798648 yjcB Shigella dysenteriae Sd197 hypothetical protein YP_405873.2 4219013 D 300267 CDS YP_405874.1 82779525 3798649 complement(4219393..4219929) 1 NC_007606.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4219929 ssb 3798649 ssb Shigella dysenteriae Sd197 single-stranded DNA-binding protein YP_405874.1 4219393 R 300267 CDS YP_405875.1 82779526 3798650 4220183..4223005 1 NC_007606.1 ''The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate''; excinuclease ABC subunit A 4223005 uvrA 3798650 uvrA Shigella dysenteriae Sd197 excinuclease ABC subunit A YP_405875.1 4220183 D 300267 CDS YP_405876.1 82779527 3798651 complement(4223040..4223396) 1 NC_007606.1 Code: S; COG: COG2315; hypothetical protein 4223396 yjbR 3798651 yjbR Shigella dysenteriae Sd197 hypothetical protein YP_405876.1 4223040 R 300267 CDS YP_405877.1 82779528 3798652 complement(4223400..4223816) 1 NC_007606.1 Code: S; COG: COG0432; hypothetical protein 4223816 yjbQ 3798652 yjbQ Shigella dysenteriae Sd197 hypothetical protein YP_405877.1 4223400 R 300267 CDS YP_405878.1 82779529 3798653 complement(4224140..4224517) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4224517 insB 3798653 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405878.1 4224140 R 300267 CDS YP_405879.1 82779530 3798654 complement(4224562..4224837) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4224837 insA 3798654 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405879.1 4224562 R 300267 CDS YP_009000885.1 578793367 18263199 4225640..4225912 1 NC_007606.1 insertion element iso-IS1N protein InsA 4225912 18263199 SDY_4811 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000885.1 4225640 D 300267 CDS YP_405882.1 82779533 3795712 4226602..4227087 1 NC_007606.1 hypothetical protein 4227087 3795712 SDY_4517 Shigella dysenteriae Sd197 hypothetical protein YP_405882.1 4226602 D 300267 CDS YP_405885.1 82779536 3795715 complement(4228095..4229288) 1 NC_007606.1 tyrosine repressible; catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4229288 tyrB 3795715 tyrB Shigella dysenteriae Sd197 aromatic amino acid aminotransferase YP_405885.1 4228095 R 300267 CDS YP_405886.1 82779537 3795716 complement(4229531..4230610) 1 NC_007606.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4230610 alr 3795716 alr Shigella dysenteriae Sd197 alanine racemase YP_405886.1 4229531 R 300267 CDS YP_405887.1 82779538 3795717 complement(4230663..4232078) 1 NC_007606.1 part of primosome; unwinds double stranded DNA; replicative DNA helicase 4232078 dnaB 3795717 dnaB Shigella dysenteriae Sd197 replicative DNA helicase YP_405887.1 4230663 R 300267 CDS YP_405888.1 82779539 3795718 4232161..4233144 1 NC_007606.1 Code: CR; COG: COG0604; quinone oxidoreductase 4233144 qor 3795718 qor Shigella dysenteriae Sd197 quinone oxidoreductase YP_405888.1 4232161 D 300267 CDS YP_405889.2 161949982 3795719 complement(4233310..4233552) 1 NC_007606.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4233552 pspG 3795719 pspG Shigella dysenteriae Sd197 phage shock protein G YP_405889.2 4233310 R 300267 CDS YP_405890.1 82779541 3795720 complement(4233686..4234723) 1 NC_007606.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase A 4234723 yjbN 3795720 yjbN Shigella dysenteriae Sd197 tRNA-dihydrouridine synthase A YP_405890.1 4233686 R 300267 CDS YP_405892.1 82779543 3795722 4235281..4235607 1 NC_007606.1 hypothetical protein 4235607 3795722 SDY_4527 Shigella dysenteriae Sd197 hypothetical protein YP_405892.1 4235281 D 300267 CDS YP_009000886.1 578793368 18263200 complement(4235569..4235859) 1 NC_007606.1 hypothetical protein 4235859 18263200 SDY_4527a Shigella dysenteriae Sd197 hypothetical protein YP_009000886.1 4235569 R 300267 CDS YP_405893.2 161949981 3795723 4236178..4236693 1 NC_007606.1 ''Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB''; zinc uptake transcriptional repressor 4236693 yjbK 3795723 yjbK Shigella dysenteriae Sd197 zinc uptake transcriptional repressor YP_405893.2 4236178 D 300267 CDS YP_405894.1 82779545 3795724 complement(4236735..4236944) 1 NC_007606.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 4236944 yjbJ 3795724 yjbJ Shigella dysenteriae Sd197 stress-response protein YP_405894.1 4236735 R 300267 CDS YP_405895.2 161949980 3795725 complement(4237060..4238385) 1 NC_007606.1 Code: V; COG: COG0534; DNA-damage-inducible SOS response protein 4238385 dinF 3795725 dinF Shigella dysenteriae Sd197 DNA-damage-inducible SOS response protein YP_405895.2 4237060 R 300267 CDS YP_405896.1 82779547 3795726 complement(4238458..4239066) 1 NC_007606.1 regulator for lexA regulon; Represses a number of genes involved in the response to DNA damage; LexA repressor 4239066 lexA 3795726 lexA Shigella dysenteriae Sd197 LexA repressor YP_405896.1 4238458 R 300267 CDS YP_405897.1 82779548 3795727 complement(4239176..4239544) 1 NC_007606.1 Code: M; COG: COG0818; diacylglycerol kinase 4239544 dgkA 3795727 dgkA Shigella dysenteriae Sd197 diacylglycerol kinase YP_405897.1 4239176 R 300267 CDS YP_405898.2 161949979 3795728 4239715..4242138 1 NC_007606.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4242138 plsB 3795728 plsB Shigella dysenteriae Sd197 glycerol-3-phosphate acyltransferase YP_405898.2 4239715 D 300267 CDS YP_405899.1 82779550 3795729 complement(4242293..4243165) 1 NC_007606.1 ''catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway''; 4-hydroxybenzoate octaprenyltransferase 4243165 ubiA 3795729 ubiA Shigella dysenteriae Sd197 4-hydroxybenzoate octaprenyltransferase YP_405899.1 4242293 R 300267 CDS YP_405900.2 161949978 3795538 complement(4243178..4243675) 1 NC_007606.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4243675 ubiC 3795538 ubiC Shigella dysenteriae Sd197 chorismate pyruvate lyase YP_405900.2 4243178 R 300267 CDS YP_405901.1 82779552 3795539 4244222..4244497 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4244497 insA 3795539 insA Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405901.1 4244222 D 300267 CDS YP_405902.1 82779553 3795540 4244542..4244919 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4244919 insB 3795540 insB Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405902.1 4244542 D 300267 CDS YP_009000887.1 578793369 18263201 4246204..4246476 1 NC_007606.1 insertion element iso-IS1N protein InsA 4246476 18263201 SDY_4812 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000887.1 4246204 D 300267 CDS YP_405903.1 82779554 3795543 4246503..4246898 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4246898 3795543 SDY_4540 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405903.1 4246503 D 300267 CDS YP_405904.1 82779555 3795544 4247198..4248073 1 NC_007606.1 Code: K; COG: COG0583; LysR family transcriptional regulator 4248073 yhjC 3795544 yhjC Shigella dysenteriae Sd197 LysR family transcriptional regulator YP_405904.1 4247198 D 300267 CDS YP_405905.1 82779556 3795545 4248122..4249135 1 NC_007606.1 Code: S; COG: COG1295; hypothetical protein 4249135 yhjD 3795545 yhjD Shigella dysenteriae Sd197 hypothetical protein YP_405905.1 4248122 D 300267 CDS YP_405906.1 82779557 3795546 4249527..4250849 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 4250849 yhjE 3795546 yhjE Shigella dysenteriae Sd197 transport protein YP_405906.1 4249527 D 300267 CDS YP_405907.1 82779558 3795547 complement(4251031..4253106) 1 NC_007606.1 Code: M; COG: COG2982; hypothetical protein 4253106 yhjG 3795547 yhjG Shigella dysenteriae Sd197 hypothetical protein YP_405907.1 4251031 R 300267 CDS YP_405908.1 82779559 3795548 complement(4253161..4253931) 1 NC_007606.1 in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase 4253931 yhjH 3795548 yhjH Shigella dysenteriae Sd197 diguanylate phosphodiesterase YP_405908.1 4253161 R 300267 CDS YP_009000888.1 578793370 3795549 4254160..4255089 1 NC_007606.1 ketodeoxygluconokinase 4255089 3795549 SDY_4546 Shigella dysenteriae Sd197 ketodeoxygluconokinase YP_009000888.1 4254160 D 300267 CDS YP_405909.1 82779560 3795550 complement(4255185..4256681) 1 NC_007606.1 Code: R; COG: COG0612; hypothetical protein 4256681 yhjJ 3795550 yhjJ Shigella dysenteriae Sd197 hypothetical protein YP_405909.1 4255185 R 300267 CDS YP_405910.1 82779561 3795551 complement(4256902..4258188) 1 NC_007606.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4258188 dctA 3795551 dctA Shigella dysenteriae Sd197 C4-dicarboxylate transporter DctA YP_405910.1 4256902 R 300267 CDS YP_405911.1 82779562 3795552 complement(4258371..4260326) 1 NC_007606.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase 4260326 yhjK 3795552 yhjK Shigella dysenteriae Sd197 phosphodiesterase YP_405911.1 4258371 R 300267 CDS YP_405912.1 82779563 3795555 complement(4265009..4267348) 1 NC_007606.1 ''binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)''; cellulose synthase regulator protein 4267348 yhjN 3795555 yhjN Shigella dysenteriae Sd197 cellulose synthase regulator protein YP_405912.1 4265009 R 300267 CDS YP_405913.2 161949977 3795556 complement(4267359..4269977) 1 NC_007606.1 ''polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis''; cellulose synthase catalytic subunit 4269977 bcsA 3795556 bcsA Shigella dysenteriae Sd197 cellulose synthase catalytic subunit YP_405913.2 4267359 R 300267 CDS YP_405914.1 82779565 3795653 complement(4270738..4270926) 1 NC_007606.1 hypothetical protein 4270926 yhjR 3795653 yhjR Shigella dysenteriae Sd197 hypothetical protein YP_405914.1 4270738 R 300267 CDS YP_405915.1 82779566 3795308 complement(4271658..4272035) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4272035 3795308 SDY_4557 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405915.1 4271658 R 300267 CDS YP_405916.1 82779567 3795309 complement(4272080..4272355) 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4272355 3795309 SDY_4558 Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405916.1 4272080 R 300267 CDS YP_405917.1 82779568 3795655 complement(4272464..4272859) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4272859 3795655 SDY_4559 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405917.1 4272464 R 300267 CDS YP_009000889.1 578793371 3795656 complement(4276254..4276451) 1 NC_007606.1 small toxic polypeptide 4276451 3795656 SDY_4560 Shigella dysenteriae Sd197 small toxic polypeptide YP_009000889.1 4276254 R 300267 CDS YP_405919.1 82779570 3795658 4276837..4278108 1 NC_007606.1 Code: E; COG: COG0814; transporter protein 4278108 yhjV 3795658 yhjV Shigella dysenteriae Sd197 transporter protein YP_405919.1 4276837 D 300267 CDS YP_405920.1 82779571 3795659 complement(4278138..4279142) 1 NC_007606.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide ABC transporter ATP-binding protein 4279142 dppF 3795659 dppF Shigella dysenteriae Sd197 dipeptide ABC transporter ATP-binding protein YP_405920.1 4278138 R 300267 CDS YP_405921.1 82779572 3795660 complement(4279139..4280122) 1 NC_007606.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide ABC transporter ATP-binding protein 4280122 dppD 3795660 dppD Shigella dysenteriae Sd197 dipeptide ABC transporter ATP-binding protein YP_405921.1 4279139 R 300267 CDS YP_405922.1 82779573 3795661 complement(4280133..4281035) 1 NC_007606.1 Code: EP; COG: COG1173; dipeptide transporter 4281035 dppC 3795661 dppC Shigella dysenteriae Sd197 dipeptide transporter YP_405922.1 4280133 R 300267 CDS YP_405923.1 82779574 3795662 complement(4281045..4282064) 1 NC_007606.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4282064 dppB 3795662 dppB Shigella dysenteriae Sd197 dipeptide transporter permease DppB YP_405923.1 4281045 R 300267 CDS YP_405924.1 82779575 3795663 complement(4282215..4283822) 1 NC_007606.1 Code: E; COG: COG0747; dipeptide transport protein 4283822 dppA 3795663 dppA Shigella dysenteriae Sd197 dipeptide transport protein YP_405924.1 4282215 R 300267 CDS YP_405925.1 82779576 3795666 complement(4285579..4286790) 1 NC_007606.1 hypothetical protein 4286790 3795666 SDY_4570 Shigella dysenteriae Sd197 hypothetical protein YP_405925.1 4285579 R 300267 CDS YP_405926.2 161949976 3795667 complement(4286802..4287707) 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4287707 3795667 SDY_4571 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405926.2 4286802 R 300267 CDS YP_405927.1 82779578 3795668 complement(4287665..4288030) 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 4288030 3795668 SDY_4572 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_405927.1 4287665 R 300267 CDS YP_405929.1 82779580 3795670 4288450..4289163 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4289163 3795670 SDY_4574 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_405929.1 4288450 D 300267 CDS YP_405930.1 82779581 3795578 complement(4292076..4292471) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4292471 3795578 SDY_4576 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405930.1 4292076 R 300267 CDS YP_009000890.1 578793372 18263202 complement(4292498..4292770) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4292770 18263202 SDY_4813 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000890.1 4292498 R 300267 CDS YP_405932.1 82779583 3795582 4293697..4294050 1 NC_007606.1 hypothetical protein 4294050 3795582 SDY_4580 Shigella dysenteriae Sd197 hypothetical protein YP_405932.1 4293697 D 300267 CDS YP_405933.1 82779584 3795310 4294119..4294394 1 NC_007606.1 Code: L; COG: COG3677; insertion element iso-IS1d protein InsA 4294394 3795310 SDY_4581 Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsA YP_405933.1 4294119 D 300267 CDS YP_405934.1 82779585 3795311 4294439..4294816 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4294816 3795311 SDY_4582 Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405934.1 4294439 D 300267 CDS YP_405936.1 82779587 3795584 4294974..4295339 1 NC_007606.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence element IS2 repressor TnpA 4295339 3795584 SDY_4584 Shigella dysenteriae Sd197 insertion sequence element IS2 repressor TnpA YP_405936.1 4294974 D 300267 CDS YP_405937.2 161949975 3795585 4295297..4296202 1 NC_007606.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4296202 3795585 SDY_4585 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_405937.2 4295297 D 300267 CDS YP_405938.1 82779589 3795586 4296302..4297066 1 NC_007606.1 Code: L; COG: COG2801; insertion sequence element IS600 integrase core domain-containing protein 4297066 3795586 SDY_4586 Shigella dysenteriae Sd197 insertion sequence element IS600 integrase core domain-containing protein YP_405938.1 4296302 D 300267 CDS YP_405940.1 82779591 3795589 4300128..4300601 1 NC_007606.1 hypothetical protein 4300601 3795589 SDY_4589 Shigella dysenteriae Sd197 hypothetical protein YP_405940.1 4300128 D 300267 CDS YP_405941.1 82779592 3795590 4300617..4301093 1 NC_007606.1 Code: L; COG: COG2003; DNA repair protein 4301093 3795590 SDY_4590 Shigella dysenteriae Sd197 DNA repair protein YP_405941.1 4300617 D 300267 CDS YP_405942.1 82779593 3795591 4301162..4301383 1 NC_007606.1 hypothetical protein 4301383 3795591 SDY_4591 Shigella dysenteriae Sd197 hypothetical protein YP_405942.1 4301162 D 300267 CDS YP_009000891.1 578793373 18263203 4301546..4301914 1 NC_007606.1 cytoskeleton bundling-enhancing factor A 4301914 18263203 SDY_4591a Shigella dysenteriae Sd197 cytoskeleton bundling-enhancing factor A YP_009000891.1 4301546 D 300267 CDS YP_405943.1 82779594 3795592 4302375..4302866 1 NC_007606.1 hypothetical protein 4302866 3795592 SDY_4592 Shigella dysenteriae Sd197 hypothetical protein YP_405943.1 4302375 D 300267 CDS YP_009000892.1 578793374 18263204 4303990..4304262 1 NC_007606.1 insertion element iso-IS1N protein InsA 4304262 18263204 SDY_4814 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000892.1 4303990 D 300267 CDS YP_405946.1 82779597 3795595 complement(4304805..4305062) 1 NC_007606.1 hypothetical protein 4305062 3795595 SDY_4595 Shigella dysenteriae Sd197 hypothetical protein YP_405946.1 4304805 R 300267 CDS YP_405947.1 82779598 3795314 complement(4305059..4305832) 1 NC_007606.1 activator of (R)-hydroxyglutaryl-CoA dehydratase; ATPase 4305832 yjiL 3795314 yjiL Shigella dysenteriae Sd197 ATPase YP_405947.1 4305059 R 300267 CDS YP_405948.1 82779599 3795317 complement(4308424..4309656) 1 NC_007606.1 Code: GEPR; COG: COG0477; transport protein 4309656 yjiO 3795317 yjiO Shigella dysenteriae Sd197 transport protein YP_405948.1 4308424 R 300267 CDS YP_405949.1 82779600 3795318 4310123..4311067 1 NC_007606.1 Code: S; COG: COG5464; hypothetical protein 4311067 3795318 SDY_4600 Shigella dysenteriae Sd197 hypothetical protein YP_405949.1 4310123 D 300267 CDS YP_405950.1 82779601 3795319 complement(4311310..4312722) 1 NC_007606.1 Code: KE; COG: COG1167; regulator 4312722 yjiR 3795319 yjiR Shigella dysenteriae Sd197 regulator YP_405950.1 4311310 R 300267 CDS YP_405951.1 82779602 3795320 4312899..4313063 1 NC_007606.1 Code: S; COG: COG5457; hypothetical protein 4313063 yjiS 3795320 yjiS Shigella dysenteriae Sd197 hypothetical protein YP_405951.1 4312899 D 300267 CDS YP_405953.1 82779604 3795322 complement(4313365..4313760) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4313760 3795322 SDY_4604 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405953.1 4313365 R 300267 CDS YP_009000893.1 578793375 18263205 complement(4313787..4314059) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4314059 18263205 SDY_4815 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000893.1 4313787 R 300267 CDS YP_405954.1 82779605 3795323 complement(4314122..4314976) 1 NC_007606.1 Code: R; COG: COG0523; GTP-binding protein YjiA 4314976 yjiA 3795323 yjiA Shigella dysenteriae Sd197 GTP-binding protein YjiA YP_405954.1 4314122 R 300267 CDS YP_405955.1 82779606 3795324 complement(4315089..4315292) 1 NC_007606.1 Code: S; COG: COG2879; hypothetical protein 4315292 yjiX 3795324 yjiX Shigella dysenteriae Sd197 hypothetical protein YP_405955.1 4315089 R 300267 CDS YP_405956.1 82779607 3795325 complement(4315423..4317588) 1 NC_007606.1 Code: T; COG: COG1966; carbon starvation protein 4317588 yjiY 3795325 yjiY Shigella dysenteriae Sd197 carbon starvation protein YP_405956.1 4315423 R 300267 CDS YP_405957.1 82779608 3795327 4320060..4320362 1 NC_007606.1 Code: L; COG: COG2963; insertion sequence element IS600 transposase 4320362 3795327 SDY_4609 Shigella dysenteriae Sd197 insertion sequence element IS600 transposase YP_405957.1 4320060 D 300267 CDS YP_405959.2 161949974 3795331 complement(4322255..4324546) 1 NC_007606.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 4324546 mdoB 3795331 mdoB Shigella dysenteriae Sd197 phosphoglycerol transferase I YP_405959.2 4322255 R 300267 CDS YP_405960.1 82779611 3795332 complement(4324800..4325297) 1 NC_007606.1 hypothetical protein 4325297 yjjA 3795332 yjjA Shigella dysenteriae Sd197 hypothetical protein YP_405960.1 4324800 R 300267 CDS YP_405961.1 82779612 3795372 complement(4325343..4326080) 1 NC_007606.1 initiation and chain elongation; acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 4326080 dnaC 3795372 dnaC Shigella dysenteriae Sd197 DNA replication protein DnaC YP_405961.1 4325343 R 300267 CDS YP_405962.1 82779613 3795373 complement(4326083..4326622) 1 NC_007606.1 primosomal protein i; ''This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'''; primosomal protein DnaI 4326622 dnaT 3795373 dnaT Shigella dysenteriae Sd197 primosomal protein DnaI YP_405962.1 4326083 R 300267 CDS YP_405963.2 228861757 3795374 complement(4326729..4327202) 1 NC_007606.1 Code: S; COG: COG3610; hypothetical protein 4327202 yjjB 3795374 yjjB Shigella dysenteriae Sd197 hypothetical protein YP_405963.2 4326729 R 300267 CDS YP_405964.1 82779615 3795312 4328009..4328284 1 NC_007606.1 Code: L; COG: COG3677; insertion element IS1 protein InsA 4328284 3795312 SDY_4618 Shigella dysenteriae Sd197 insertion element IS1 protein InsA YP_405964.1 4328009 D 300267 CDS YP_405965.1 82779616 3795313 4328329..4328706 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1d protein InsB 4328706 3795313 SDY_4619 Shigella dysenteriae Sd197 insertion element iso-IS1d protein InsB YP_405965.1 4328329 D 300267 CDS YP_405966.1 82779617 3795376 complement(4329068..4329463) 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4329463 3795376 SDY_4621 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405966.1 4329068 R 300267 CDS YP_009000894.1 578793376 18263206 complement(4329490..4329762) 1 NC_007606.1 insertion element iso-IS1N protein InsA 4329762 18263206 SDY_4816 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000894.1 4329490 R 300267 CDS YP_009000895.1 578793377 18263207 4330439..4330735 1 NC_007606.1 insertion element iso-IS1N protein InsA 4330735 18263207 SDY_4817 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000895.1 4330439 D 300267 CDS YP_405967.1 82779618 3795378 4330737..4331132 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4331132 3795378 SDY_4623 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405967.1 4330737 D 300267 CDS YP_405968.1 82779619 3795380 complement(4332304..4333092) 1 NC_007606.1 Code: R; COG: COG4114; ferric hydroximate transport ferric iron reductase 4333092 fhuF 3795380 fhuF Shigella dysenteriae Sd197 ferric hydroximate transport ferric iron reductase YP_405968.1 4332304 R 300267 CDS YP_405969.2 578793378 3795381 4333233..4333469 1 NC_007606.1 hypothetical protein 4333469 3795381 SDY_4626 Shigella dysenteriae Sd197 hypothetical protein YP_405969.2 4333233 D 300267 CDS YP_405970.1 82779621 3795385 complement(4334031..4335062) 1 NC_007606.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 4335062 rsmC 3795385 rsmC Shigella dysenteriae Sd197 16S ribosomal RNA m2G1207 methyltransferase YP_405970.1 4334031 R 300267 CDS YP_405971.1 82779622 3795386 4335165..4335578 1 NC_007606.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4335578 holD 3795386 holD Shigella dysenteriae Sd197 DNA polymerase III subunit psi YP_405971.1 4335165 D 300267 CDS YP_405972.1 82779623 3795387 4335547..4335993 1 NC_007606.1 acetylation of N-terminal alanine; alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4335993 rimI 3795387 rimI Shigella dysenteriae Sd197 ribosomal-protein-alanine N-acetyltransferase YP_405972.1 4335547 D 300267 CDS YP_405973.1 82779624 3795333 4336008..4336685 1 NC_007606.1 ''manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily''; nucleotidase 4336685 yjjG 3795333 yjjG Shigella dysenteriae Sd197 nucleotidase YP_405973.1 4336008 D 300267 CDS YP_405974.1 82779625 3795334 4336776..4338365 1 NC_007606.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4338365 prfC 3795334 prfC Shigella dysenteriae Sd197 peptide chain release factor 3 YP_405974.1 4336776 D 300267 CDS YP_009000896.1 578793379 18263208 4338484..4338756 1 NC_007606.1 insertion element iso-IS1N protein InsA 4338756 18263208 SDY_4818 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000896.1 4338484 D 300267 CDS YP_405975.1 82779626 3795335 4338783..4339178 1 NC_007606.1 Code: L; COG: COG1662; insertion element iso-IS1n protein InsB 4339178 3795335 SDY_4635 Shigella dysenteriae Sd197 insertion element iso-IS1n protein InsB YP_405975.1 4338783 D 300267 CDS YP_405976.1 82779627 3795336 4339532..4340137 1 NC_007606.1 Code: R; COG: COG2823; hypothetical protein 4340137 osmY 3795336 osmY Shigella dysenteriae Sd197 hypothetical protein YP_405976.1 4339532 D 300267 CDS YP_009000897.1 578793380 18263209 4340264..4340425 1 NC_007606.1 hypothetical protein 4340425 18263209 SDY_4636a Shigella dysenteriae Sd197 hypothetical protein YP_009000897.1 4340264 D 300267 CDS YP_405977.1 82779628 3795337 4340547..4341620 1 NC_007606.1 Code: R; COG: COG4667; hypothetical protein 4341620 yjjU 3795337 yjjU Shigella dysenteriae Sd197 hypothetical protein YP_405977.1 4340547 D 300267 CDS YP_405978.1 82779629 3795338 4341617..4342399 1 NC_007606.1 Code: L; COG: COG0084; deoxyribonuclease YjjV 4342399 yjjV 3795338 yjjV Shigella dysenteriae Sd197 deoxyribonuclease YjjV YP_405978.1 4341617 D 300267 CDS YP_405979.1 82779630 3795339 complement(4342612..4343475) 1 NC_007606.1 Code: O; COG: COG1180; activating enzyme 4343475 yjjW 3795339 yjjW Shigella dysenteriae Sd197 activating enzyme YP_405979.1 4342612 R 300267 CDS YP_405980.1 82779631 3795340 complement(4343447..4344997) 1 NC_007606.1 hypothetical protein 4344997 yjjI 3795340 yjjI Shigella dysenteriae Sd197 hypothetical protein YP_405980.1 4343447 R 300267 CDS YP_405981.1 82779632 3795341 4345255..4346034 1 NC_007606.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4346034 deoC 3795341 deoC Shigella dysenteriae Sd197 deoxyribose-phosphate aldolase YP_405981.1 4345255 D 300267 CDS YP_405982.1 82779633 3795342 4346161..4347483 1 NC_007606.1 ''Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate''; thymidine phosphorylase 4347483 deoA 3795342 deoA Shigella dysenteriae Sd197 thymidine phosphorylase YP_405982.1 4346161 D 300267 CDS YP_405983.1 82779634 3795343 4347535..4348758 1 NC_007606.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4348758 deoB 3795343 deoB Shigella dysenteriae Sd197 phosphopentomutase YP_405983.1 4347535 D 300267 CDS YP_405984.1 82779635 3795344 4348838..4349557 1 NC_007606.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4349557 deoD 3795344 deoD Shigella dysenteriae Sd197 purine nucleoside phosphorylase YP_405984.1 4348838 D 300267 CDS YP_009000898.1 578793381 18263210 4349760..4350032 1 NC_007606.1 insertion element iso-IS1N protein InsA 4350032 18263210 SDY_4819 Shigella dysenteriae Sd197 insertion element iso-IS1N protein InsA YP_009000898.1 4349760 D 300267 CDS YP_405985.1 82779636 3795345 4350059..4350454 1 NC_007606.1 Code: L; COG: COG1662; insertion element IS1 protein InsB 4350454 3795345 SDY_4645 Shigella dysenteriae Sd197 insertion element IS1 protein InsB YP_405985.1 4350059 D 300267 CDS YP_405986.1 82779637 3795346 complement(4350492..4350755) 1 NC_007606.1 Code: K; COG: COG1396; hypothetical protein 4350755 3795346 SDY_4646 Shigella dysenteriae Sd197 hypothetical protein YP_405986.1 4350492 R 300267 CDS YP_405987.1 82779638 3795347 complement(4350787..4351803) 1 NC_007606.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 4351803 lplA 3795347 lplA Shigella dysenteriae Sd197 lipoate-protein ligase A YP_405987.1 4350787 R 300267 CDS YP_405988.1 82779639 3795348 complement(4351831..4352475) 1 NC_007606.1 Code: R; COG: COG3726; hypothetical protein 4352475 smp 3795348 smp Shigella dysenteriae Sd197 hypothetical protein YP_405988.1 4351831 R 300267 CDS YP_405989.1 82779640 3795349 4352581..4353549 1 NC_007606.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4353549 serB 3795349 serB Shigella dysenteriae Sd197 phosphoserine phosphatase YP_405989.1 4352581 D 300267 CDS YP_405990.1 82779641 3795350 4353598..4354980 1 NC_007606.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4354980 sms 3795350 sms Shigella dysenteriae Sd197 DNA repair protein RadA YP_405990.1 4353598 D 300267 CDS YP_405991.2 161949973 3795351 4355001..4356233 1 NC_007606.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4356233 nadR 3795351 nadR Shigella dysenteriae Sd197 nicotinamide-nucleotide adenylyltransferase YP_405991.2 4355001 D 300267 CDS YP_405992.1 82779643 3795352 complement(4356540..4358207) 1 NC_007606.1 ''ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence''; ABC transporter ATP-binding protein 4358207 yjjK 3795352 yjjK Shigella dysenteriae Sd197 ABC transporter ATP-binding protein YP_405992.1 4356540 R 300267 CDS YP_405993.2 161949972 3795296 4358418..4360355 1 NC_007606.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4360355 slt 3795296 slt Shigella dysenteriae Sd197 lytic murein transglycosylase YP_405993.2 4358418 D 300267 CDS YP_405994.1 82779645 3795297 4360445..4360771 1 NC_007606.1 trp aporepressor; When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4360771 trpR 3795297 trpR Shigella dysenteriae Sd197 Trp operon repressor YP_405994.1 4360445 D 300267 CDS YP_405995.2 161949971 3795298 complement(4360814..4361326) 1 NC_007606.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 4361326 yjjX 3795298 yjjX Shigella dysenteriae Sd197 NTPase YP_405995.2 4360814 R 300267 CDS YP_405996.1 82779647 3795299 4361378..4362025 1 NC_007606.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4362025 gpmB 3795299 gpmB Shigella dysenteriae Sd197 phosphoglycerate mutase YP_405996.1 4361378 D 300267 CDS YP_405997.1 82779648 3795300 complement(4362022..4362891) 1 NC_007606.1 Code: K; COG: COG2207; right origin-binding protein 4362891 rob 3795300 rob Shigella dysenteriae Sd197 right origin-binding protein YP_405997.1 4362022 R 300267 CDS YP_405998.1 82779649 3795301 4363102..4363575 1 NC_007606.1 Code: S; COG: COG3045; hypothetical protein 4363575 creA 3795301 creA Shigella dysenteriae Sd197 hypothetical protein YP_405998.1 4363102 D 300267 CDS YP_405999.1 82779650 3795302 4363588..4364277 1 NC_007606.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4364277 creB 3795302 creB Shigella dysenteriae Sd197 DNA-binding response regulator CreB YP_405999.1 4363588 D 300267 CDS YP_406000.1 82779651 3795305 complement(4367170..4367886) 1 NC_007606.1 sensors, ArcB and CpxA; Code: TK; COG: COG0745; two-component response regulator 4367886 arcA 3795305 arcA Shigella dysenteriae Sd197 two-component response regulator YP_406000.1 4367170 R 300267 CDS YP_406001.1 82779652 3795306 4367982..4368122 1 NC_007606.1 hypothetical protein 4368122 yjjY 3795306 yjjY Shigella dysenteriae Sd197 hypothetical protein YP_406001.1 4367982 D 300267 CDS YP_406002.1 82779653 3795307 4368522..4369208 1 NC_007606.1 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4369208 lasT 3795307 lasT Shigella dysenteriae Sd197 RNA methyltransferase YP_406002.1 4368522 D 300267 CDS YP_406003.1 82524409 3776545 complement(191..367) 1 NC_007607.1 IS2 ORF2 367 3776545 SDY_P002 Shigella dysenteriae Sd197 IS2 ORF2 YP_406003.1 191 R 300267 CDS YP_406004.1 82524408 3776544 359..823 1 NC_007607.1 putative resolvase, fragment 823 3776544 SDY_P001 Shigella dysenteriae Sd197 putative resolvase, fragment YP_406004.1 359 D 300267 CDS YP_406005.1 82524410 3776546 1233..1916 1 NC_007607.1 protein secreted by the Mxi-Spa secretion machinery; OspB 1916 ospB 3776546 ospB Shigella dysenteriae Sd197 OspB YP_406005.1 1233 D 300267 CDS YP_406006.1 82524411 3776547 2244..2984 1 NC_007607.1 periplasmic phosphatase, apyrase, ATP diphosphohydrolase; PhoN2/Apy 2984 phoN2/apy 3776547 phoN2/apy Shigella dysenteriae Sd197 PhoN2/Apy YP_406006.1 2244 D 300267 CDS YP_406007.1 82524412 3776548 4663..5058 1 NC_007607.1 iso-IS1 ORF2 5058 3776548 SDY_P005 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406007.1 4663 D 300267 CDS YP_406008.1 82524413 3776550 complement(5493..5894) 1 NC_007607.1 ISEc8 orf, fragment 5894 3776550 SDY_P007 Shigella dysenteriae Sd197 ISEc8 orf, fragment YP_406008.1 5493 R 300267 CDS YP_406009.1 82524414 3776551 complement(5974..6396) 1 NC_007607.1 IS600 ORF2 6396 3776551 SDY_P008 Shigella dysenteriae Sd197 IS600 ORF2 YP_406009.1 5974 R 300267 CDS YP_406010.1 82524415 3776552 complement(6432..6734) 1 NC_007607.1 IS600 ORF1 6734 3776552 SDY_P009 Shigella dysenteriae Sd197 IS600 ORF1 YP_406010.1 6432 R 300267 CDS YP_406011.1 82524416 3776553 complement(7424..9142) 1 NC_007607.1 probably secreted by the Mxi-Spa secretion machinery; OspD2 9142 ospD2 3776553 ospD2 Shigella dysenteriae Sd197 OspD2 YP_406011.1 7424 R 300267 CDS YP_406012.2 161986650 3776554 complement(9498..10403) 1 NC_007607.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 10403 3776554 SDY_P011 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_406012.2 9498 R 300267 CDS YP_406013.1 82524418 3776555 complement(10361..10726) 1 NC_007607.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 10726 3776555 SDY_P012 Shigella dysenteriae Sd197 insertion sequence 2 OrfA protein YP_406013.1 10361 R 300267 CDS YP_406014.1 82524419 3776469 complement(10901..11620) 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; OspF 11620 ospF 3776469 ospF Shigella dysenteriae Sd197 OspF YP_406014.1 10901 R 300267 CDS YP_406015.1 82524420 3776470 complement(11826..12203) 1 NC_007607.1 putative transposase 12203 3776470 SDY_P014 Shigella dysenteriae Sd197 putative transposase YP_406015.1 11826 R 300267 CDS YP_406016.1 82524421 3776471 complement(12740..13318) 1 NC_007607.1 hypothetical protein 13318 3776471 SDY_P015 Shigella dysenteriae Sd197 hypothetical protein YP_406016.1 12740 R 300267 CDS YP_406017.1 82524422 3776472 complement(13547..13666) 1 NC_007607.1 IS3 orf2, fragment 13666 3776472 SDY_P016 Shigella dysenteriae Sd197 IS3 orf2, fragment YP_406017.1 13547 R 300267 CDS YP_406018.1 82524424 3776474 complement(14289..14690) 1 NC_007607.1 IS91 orf 14690 3776474 SDY_P018 Shigella dysenteriae Sd197 IS91 orf YP_406018.1 14289 R 300267 CDS YP_406019.1 82524423 3776473 14675..14962 1 NC_007607.1 hypothetical protein 14962 3776473 SDY_P017 Shigella dysenteriae Sd197 hypothetical protein YP_406019.1 14675 D 300267 CDS YP_406020.1 82524425 3776475 15233..15640 1 NC_007607.1 putative IS orf, fragment 15640 3776475 SDY_P019 Shigella dysenteriae Sd197 putative IS orf, fragment YP_406020.1 15233 D 300267 CDS YP_406021.1 82524426 3776476 15640..15987 1 NC_007607.1 ISSfl4 ORF2 15987 3776476 SDY_P020 Shigella dysenteriae Sd197 ISSfl4 ORF2 YP_406021.1 15640 D 300267 CDS YP_406022.1 82524427 3776477 16115..17314 1 NC_007607.1 putative IS orf, fragment 17314 3776477 SDY_P021 Shigella dysenteriae Sd197 putative IS orf, fragment YP_406022.1 16115 D 300267 CDS YP_406023.1 82524428 3776478 18083..18289 1 NC_007607.1 putative transposase, fragment 18289 3776478 SDY_P022 Shigella dysenteriae Sd197 putative transposase, fragment YP_406023.1 18083 D 300267 CDS YP_406024.1 82524429 3776479 18877..19554 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; OspD1 19554 ospD1 3776479 ospD1 Shigella dysenteriae Sd197 OspD1 YP_406024.1 18877 D 300267 CDS YP_406025.1 82524430 3776480 complement(20036..20260) 1 NC_007607.1 hypothetical protein 20260 3776480 SDY_P024 Shigella dysenteriae Sd197 hypothetical protein YP_406025.1 20036 R 300267 CDS YP_406026.1 82524431 3776481 20653..21228 1 NC_007607.1 probably secreted by the Mxi-Spa secretion machinery; IpgB2 21228 ipgB2 3776481 ipgB2 Shigella dysenteriae Sd197 IpgB2 YP_406026.1 20653 D 300267 CDS YP_406027.1 82524432 3776482 21800..22099 1 NC_007607.1 IS3 ORF1 22099 3776482 SDY_P026 Shigella dysenteriae Sd197 IS3 ORF1 YP_406027.1 21800 D 300267 CDS YP_406028.1 82524433 3776483 22096..22965 1 NC_007607.1 IS3 ORF2 22965 3776483 SDY_P027 Shigella dysenteriae Sd197 IS3 ORF2 YP_406028.1 22096 D 300267 CDS YP_406029.1 82524434 3776484 23305..23577 1 NC_007607.1 iso-IS1 ORF1 23577 3776484 SDY_P028 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406029.1 23305 D 300267 CDS YP_406030.1 82524435 3776485 23820..24908 1 NC_007607.1 IS100 ORF1 24908 3776485 SDY_P029 Shigella dysenteriae Sd197 IS100 ORF1 YP_406030.1 23820 D 300267 CDS YP_406031.1 82524436 3776486 24880..25521 1 NC_007607.1 transposase/IS protein 25521 3776486 SDY_P030 Shigella dysenteriae Sd197 transposase/IS protein YP_406031.1 24880 D 300267 CDS YP_406032.1 82524437 3776487 26268..27467 1 NC_007607.1 plasmid segregation protein 27467 parA 3776487 parA Shigella dysenteriae Sd197 plasmid segregation protein YP_406032.1 26268 D 300267 CDS YP_406033.1 82524438 3776631 27467..28447 1 NC_007607.1 plasmid segregation protein 28447 parB 3776631 parB Shigella dysenteriae Sd197 plasmid segregation protein YP_406033.1 27467 D 300267 CDS YP_406034.1 82524439 3776632 28703..29188 1 NC_007607.1 putative transposase, fragment 29188 3776632 SDY_P033 Shigella dysenteriae Sd197 putative transposase, fragment YP_406034.1 28703 D 300267 CDS YP_406035.1 82524440 3776633 complement(29477..30604) 1 NC_007607.1 putative reverse transcriptase 30604 3776633 SDY_P034 Shigella dysenteriae Sd197 putative reverse transcriptase YP_406035.1 29477 R 300267 CDS YP_406036.1 82524441 3776634 complement(31384..32007) 1 NC_007607.1 IS629 ORF2 32007 3776634 SDY_P035 Shigella dysenteriae Sd197 IS629 ORF2 YP_406036.1 31384 R 300267 CDS YP_406037.1 82524442 3776635 32204..32524 1 NC_007607.1 hypothetical protein 32524 3776635 SDY_P036 Shigella dysenteriae Sd197 hypothetical protein YP_406037.1 32204 D 300267 CDS YP_406038.1 82524443 3776636 complement(32657..34381) 1 NC_007607.1 probably secreted by the Mxi-Spa machinery; invasion plasmid antigen 34381 ipaH4.5 3776636 ipaH4.5 Shigella dysenteriae Sd197 invasion plasmid antigen YP_406038.1 32657 R 300267 CDS YP_406039.1 82524444 3776637 complement(34809..36506) 1 NC_007607.1 probably secreted by the Mxi-Spa machinery; invasion plasmid antigen 36506 ipaH7.8 3776637 ipaH7.8 Shigella dysenteriae Sd197 invasion plasmid antigen YP_406039.1 34809 R 300267 CDS YP_406040.1 82524445 3776638 complement(37326..37700) 1 NC_007607.1 IS600 ORF2 37700 3776638 SDY_P039 Shigella dysenteriae Sd197 IS600 ORF2 YP_406040.1 37326 R 300267 CDS YP_406041.1 82524446 3776639 complement(37678..38133) 1 NC_007607.1 IS600 ORF2 38133 3776639 SDY_P040 Shigella dysenteriae Sd197 IS600 ORF2 YP_406041.1 37678 R 300267 CDS YP_406042.1 82524447 3776640 complement(38236..38613) 1 NC_007607.1 IS1 ORF2 38613 insB 3776640 insB Shigella dysenteriae Sd197 IS1 ORF2 YP_406042.1 38236 R 300267 CDS YP_406043.1 82524448 3776641 39246..39695 1 NC_007607.1 ISSfl1 ORF1 39695 3776641 SDY_P042 Shigella dysenteriae Sd197 ISSfl1 ORF1 YP_406043.1 39246 D 300267 CDS YP_406044.1 82524449 3776642 39701..40090 1 NC_007607.1 ISSfl1 ORF2 40090 3776642 SDY_P043 Shigella dysenteriae Sd197 ISSfl1 ORF2 YP_406044.1 39701 D 300267 CDS YP_406045.1 82524450 3776643 40229..40396 1 NC_007607.1 hypothetical protein 40396 3776643 SDY_P044 Shigella dysenteriae Sd197 hypothetical protein YP_406045.1 40229 D 300267 CDS YP_406046.1 82524451 3776644 complement(40414..42162) 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; invasion plasmid antigen 42162 ipaH1.4 3776644 ipaH1.4 Shigella dysenteriae Sd197 invasion plasmid antigen YP_406046.1 40414 R 300267 CDS YP_406047.1 82524452 3776645 complement(42529..42795) 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; OspE1 42795 ospE1 3776645 ospE1 Shigella dysenteriae Sd197 OspE1 YP_406047.1 42529 R 300267 CDS YP_406048.1 82524453 3776646 complement(42851..43135) 1 NC_007607.1 IS1 ORF, fragment 43135 3776646 SDY_P047 Shigella dysenteriae Sd197 IS1 ORF, fragment YP_406048.1 42851 R 300267 CDS YP_406049.1 82524454 3776647 43633..43935 1 NC_007607.1 IS600 ORF1 43935 3776647 SDY_P048 Shigella dysenteriae Sd197 IS600 ORF1 YP_406049.1 43633 D 300267 CDS YP_406050.1 82524455 3776466 complement(44084..44479) 1 NC_007607.1 iso-IS1 ORF2 44479 3776466 SDY_P049 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406050.1 44084 R 300267 CDS YP_406051.1 82524456 3776467 complement(44506..44778) 1 NC_007607.1 iso-IS1 ORF1 44778 3776467 SDY_P050 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406051.1 44506 R 300267 CDS YP_406052.1 82524457 3776468 complement(44973..45620) 1 NC_007607.1 IS629 ORF2 45620 3776468 SDY_P051 Shigella dysenteriae Sd197 IS629 ORF2 YP_406052.1 44973 R 300267 CDS YP_406053.1 82524458 3776556 45781..46101 1 NC_007607.1 hypothetical protein 46101 3776556 SDY_P052 Shigella dysenteriae Sd197 hypothetical protein YP_406053.1 45781 D 300267 CDS YP_406054.1 82524459 3776648 complement(46208..46537) 1 NC_007607.1 putative transposase 46537 3776648 SDY_P053 Shigella dysenteriae Sd197 putative transposase YP_406054.1 46208 R 300267 CDS YP_406055.1 82524460 3776649 complement(46613..46786) 1 NC_007607.1 hypothetical protein 46786 3776649 SDY_P054 Shigella dysenteriae Sd197 hypothetical protein YP_406055.1 46613 R 300267 CDS YP_406056.1 82524461 3776650 47797..49209 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; OspC1 49209 ospC1 3776650 ospC1 Shigella dysenteriae Sd197 OspC1 YP_406056.1 47797 D 300267 CDS YP_406057.1 82524462 3776651 49566..51215 1 NC_007607.1 SenA; probably secreted by the Mxi-Spa secretion machinery; OspD3 51215 ospD3 3776651 ospD3 Shigella dysenteriae Sd197 OspD3 YP_406057.1 49566 D 300267 CDS YP_406058.1 82524463 3776652 complement(51512..51907) 1 NC_007607.1 iso-IS1 ORF2 51907 3776652 SDY_P057 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406058.1 51512 R 300267 CDS YP_406059.1 82524464 3776653 complement(51934..52206) 1 NC_007607.1 iso-IS1 ORF1 52206 3776653 SDY_P058 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406059.1 51934 R 300267 CDS YP_406060.1 82524465 3776654 52421..52549 1 NC_007607.1 putative transposase, fragment 52549 3776654 SDY_P059 Shigella dysenteriae Sd197 putative transposase, fragment YP_406060.1 52421 D 300267 CDS YP_406061.1 82524466 3776655 52645..53223 1 NC_007607.1 putative transposase 53223 3776655 SDY_P060 Shigella dysenteriae Sd197 putative transposase YP_406061.1 52645 D 300267 CDS YP_406062.1 82524467 3776656 53208..53498 1 NC_007607.1 hypothetical protein 53498 3776656 SDY_P061 Shigella dysenteriae Sd197 hypothetical protein YP_406062.1 53208 D 300267 CDS YP_406063.1 82524469 3776658 complement(53802..54053) 1 NC_007607.1 hypothetical protein 54053 3776658 SDY_P063 Shigella dysenteriae Sd197 hypothetical protein YP_406063.1 53802 R 300267 CDS YP_406064.1 82524468 3776657 54044..54934 1 NC_007607.1 IS629 ORF2 54934 3776657 SDY_P062 Shigella dysenteriae Sd197 IS629 ORF2 YP_406064.1 54044 D 300267 CDS YP_406065.1 82524470 3776659 55224..56927 1 NC_007607.1 probable periplasmic UDP-sugar hydrolase; catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor 56927 ushA 3776659 ushA Shigella dysenteriae Sd197 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor YP_406065.1 55224 D 300267 CDS YP_406066.1 82524471 3776660 56996..57268 1 NC_007607.1 iso-IS1 ORF1 57268 3776660 SDY_P065 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406066.1 56996 D 300267 CDS YP_406067.1 82524472 3776661 57295..57690 1 NC_007607.1 iso-IS1 ORF2 57690 3776661 SDY_P066 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406067.1 57295 D 300267 CDS YP_406068.1 82524473 3776662 58105..58854 1 NC_007607.1 periplasmic non specific acid ohosphatase; PhoN1 58854 phoN1 3776662 phoN1 Shigella dysenteriae Sd197 PhoN1 YP_406068.1 58105 D 300267 CDS YP_406069.1 82524474 3776663 complement(59024..59413) 1 NC_007607.1 ISSfl1 ORF2 59413 3776663 SDY_P068 Shigella dysenteriae Sd197 ISSfl1 ORF2 YP_406069.1 59024 R 300267 CDS YP_406070.1 82524475 3776664 complement(59419..59643) 1 NC_007607.1 ISSfl1 ORF1 59643 3776664 SDY_P069 Shigella dysenteriae Sd197 ISSfl1 ORF1 YP_406070.1 59419 R 300267 CDS YP_406071.1 82524476 3776665 60293..61747 1 NC_007607.1 probably secreted by the Mxi-Spa secretion machinery; OspC2 61747 ospC2 3776665 ospC2 Shigella dysenteriae Sd197 OspC2 YP_406071.1 60293 D 300267 CDS YP_406072.1 82524477 3776573 complement(61897..62286) 1 NC_007607.1 ISSfl1 ORF2 62286 3776573 SDY_P071 Shigella dysenteriae Sd197 ISSfl1 ORF2 YP_406072.1 61897 R 300267 CDS YP_406073.1 82524478 3776574 complement(62292..62741) 1 NC_007607.1 ISSfl1 ORF1 62741 3776574 SDY_P072 Shigella dysenteriae Sd197 ISSfl1 ORF1 YP_406073.1 62292 R 300267 CDS YP_406074.1 82524479 3776575 complement(62787..63161) 1 NC_007607.1 hypothetical protein 63161 3776575 SDY_P073 Shigella dysenteriae Sd197 hypothetical protein YP_406074.1 62787 R 300267 CDS YP_406075.1 82524480 3776576 complement(63347..63742) 1 NC_007607.1 plasmid stable inheritance protein 63742 stbB 3776576 stbB Shigella dysenteriae Sd197 plasmid stable inheritance protein YP_406075.1 63347 R 300267 CDS YP_406076.1 82524481 3776577 complement(63742..64701) 1 NC_007607.1 plasmid stable inheritance protein 64701 stbA 3776577 stbA Shigella dysenteriae Sd197 plasmid stable inheritance protein YP_406076.1 63742 R 300267 CDS YP_406077.1 82524482 3776578 65116..65511 1 NC_007607.1 hypothetical protein 65511 3776578 SDY_P076 Shigella dysenteriae Sd197 hypothetical protein YP_406077.1 65116 D 300267 CDS YP_406078.1 82524483 3776579 complement(65508..66221) 1 NC_007607.1 IS600 ORF2 66221 3776579 SDY_P077 Shigella dysenteriae Sd197 IS600 ORF2 YP_406078.1 65508 R 300267 CDS YP_406079.1 82524484 3776580 complement(66288..66665) 1 NC_007607.1 IS1 ORF2 66665 insB 3776580 insB Shigella dysenteriae Sd197 IS1 ORF2 YP_406079.1 66288 R 300267 CDS YP_406080.1 82524485 3776581 complement(67139..67441) 1 NC_007607.1 IS600 ORF1 67441 3776581 SDY_P079 Shigella dysenteriae Sd197 IS600 ORF1 YP_406080.1 67139 R 300267 CDS YP_406081.1 82524486 3776582 complement(67698..67853) 1 NC_007607.1 hypothetical protein 67853 3776582 SDY_P080 Shigella dysenteriae Sd197 hypothetical protein YP_406081.1 67698 R 300267 CDS YP_406082.1 82524487 3776583 complement(68076..68294) 1 NC_007607.1 IS2 orf1, fragment 68294 3776583 SDY_P081 Shigella dysenteriae Sd197 IS2 orf1, fragment YP_406082.1 68076 R 300267 CDS YP_406083.1 82524488 3776584 complement(68349..68987) 1 NC_007607.1 hypothetical protein 68987 3776584 SDY_P082 Shigella dysenteriae Sd197 hypothetical protein YP_406083.1 68349 R 300267 CDS YP_406084.1 82524489 3776585 complement(69343..69615) 1 NC_007607.1 iso-IS1 ORF1 69615 3776585 SDY_P083 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406084.1 69343 R 300267 CDS YP_406085.1 82524490 3776586 69951..70184 1 NC_007607.1 IS100 ORF2 70184 3776586 SDY_P084 Shigella dysenteriae Sd197 IS100 ORF2 YP_406085.1 69951 D 300267 CDS YP_406086.1 82524491 3776587 complement(70236..70526) 1 NC_007607.1 hypothetical protein 70526 3776587 SDY_P085 Shigella dysenteriae Sd197 hypothetical protein YP_406086.1 70236 R 300267 CDS YP_406087.1 82524492 3776588 complement(70533..70745) 1 NC_007607.1 hypothetical protein 70745 3776588 SDY_P086 Shigella dysenteriae Sd197 hypothetical protein YP_406087.1 70533 R 300267 CDS YP_406088.1 82524493 3776589 71197..71481 1 NC_007607.1 hypothetical protein 71481 3776589 SDY_P087 Shigella dysenteriae Sd197 hypothetical protein YP_406088.1 71197 D 300267 CDS YP_406089.1 82524494 3776590 71481..71756 1 NC_007607.1 hypothetical protein 71756 3776590 SDY_P088 Shigella dysenteriae Sd197 hypothetical protein YP_406089.1 71481 D 300267 CDS YP_406090.1 82524495 3776591 71809..71982 1 NC_007607.1 hypothetical protein 71982 3776591 SDY_P089 Shigella dysenteriae Sd197 hypothetical protein YP_406090.1 71809 D 300267 CDS YP_406091.1 82524496 3776592 complement(72117..72482) 1 NC_007607.1 plasmid stable inheritance protein 72482 3776592 SDY_P090 Shigella dysenteriae Sd197 plasmid stable inheritance protein YP_406091.1 72117 R 300267 CDS YP_406092.1 82524498 3776594 complement(72514..73011) 1 NC_007607.1 putative plasmid stable inheritance protein 73011 3776594 SDY_P092 Shigella dysenteriae Sd197 putative plasmid stable inheritance protein YP_406092.1 72514 R 300267 CDS YP_406093.1 82524497 3776593 73010..73771 1 NC_007607.1 putative IS orf, fragment 73771 3776593 SDY_P091 Shigella dysenteriae Sd197 putative IS orf, fragment YP_406093.1 73010 D 300267 CDS YP_406094.1 82524499 3776595 73771..74151 1 NC_007607.1 putative IS orf, fragment 74151 3776595 SDY_P093 Shigella dysenteriae Sd197 putative IS orf, fragment YP_406094.1 73771 D 300267 CDS YP_406095.1 82524500 3776596 complement(74527..74742) 1 NC_007607.1 iso-IS1 ORF2 74742 3776596 SDY_P094 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406095.1 74527 R 300267 CDS YP_406096.1 82524501 3776597 complement(74948..75220) 1 NC_007607.1 iso-IS1 ORF1 75220 3776597 SDY_P095 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406096.1 74948 R 300267 CDS YP_406097.1 82524502 3776598 75460..75678 1 NC_007607.1 plasmid maintenance protein CcdA 75678 ccdA 3776598 ccdA Shigella dysenteriae Sd197 plasmid maintenance protein CcdA YP_406097.1 75460 D 300267 CDS YP_406098.1 82524503 3776599 75680..75985 1 NC_007607.1 controlled cell death protein; post-segregation toxin; toxin addiction system; plasmid maintenance protein CcdB 75985 ccdB 3776599 ccdB Shigella dysenteriae Sd197 plasmid maintenance protein CcdB YP_406098.1 75680 D 300267 CDS YP_406099.1 82524504 3776600 76543..76938 1 NC_007607.1 iso-IS1 ORF2 76938 3776600 SDY_P098 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406099.1 76543 D 300267 CDS YP_406100.1 82524505 3776601 77122..78789 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; invasion plasmid antigen 78789 ipaH9.8 3776601 ipaH9.8 Shigella dysenteriae Sd197 invasion plasmid antigen YP_406100.1 77122 D 300267 CDS YP_406101.1 82524506 3776602 78997..79266 1 NC_007607.1 hypothetical protein 79266 yacA 3776602 yacA Shigella dysenteriae Sd197 hypothetical protein YP_406101.1 78997 D 300267 CDS YP_406102.1 82524507 3776603 79518..80108 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; OspG 80108 ospG 3776603 ospG Shigella dysenteriae Sd197 OspG YP_406102.1 79518 D 300267 CDS YP_406103.1 82524508 3776604 80513..80755 1 NC_007607.1 putative IS orf 80755 3776604 SDY_P102 Shigella dysenteriae Sd197 putative IS orf YP_406103.1 80513 D 300267 CDS YP_406104.1 82524509 3776605 80794..82140 1 NC_007607.1 IS4 orf 82140 3776605 SDY_P103 Shigella dysenteriae Sd197 IS4 orf YP_406104.1 80794 D 300267 CDS YP_406105.1 82524510 3776606 complement(82151..82393) 1 NC_007607.1 putative IS orf 82393 3776606 SDY_P104 Shigella dysenteriae Sd197 putative IS orf YP_406105.1 82151 R 300267 CDS YP_406106.1 82524511 3776607 82491..82709 1 NC_007607.1 IS3 ORF2 82709 3776607 SDY_P105 Shigella dysenteriae Sd197 IS3 ORF2 YP_406106.1 82491 D 300267 CDS YP_406107.1 82524512 3776608 complement(82697..85546) 1 NC_007607.1 hypothetical protein 85546 3776608 SDY_P106 Shigella dysenteriae Sd197 hypothetical protein YP_406107.1 82697 R 300267 CDS YP_406108.1 82524513 3776609 86143..86934 1 NC_007607.1 putative carbohydrate transport protein 86934 shf 3776609 shf Shigella dysenteriae Sd197 putative carbohydrate transport protein YP_406108.1 86143 D 300267 CDS YP_406109.1 82524514 3776610 87084..88025 1 NC_007607.1 UDP-sugar hydrolase 88025 rfbU 3776610 rfbU Shigella dysenteriae Sd197 UDP-sugar hydrolase YP_406109.1 87084 D 300267 CDS YP_406110.1 82524515 3776611 88030..88980 1 NC_007607.1 required for proper localization of IcsA (VirG) at the surface of bacteria; VirK 88980 virK 3776611 virK Shigella dysenteriae Sd197 VirK YP_406110.1 88030 D 300267 CDS YP_406111.1 82524516 3776666 89045..89989 1 NC_007607.1 probable lipid A transacetylase; Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 89989 msbB2 3776666 msbB2 Shigella dysenteriae Sd197 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_406111.1 89045 D 300267 CDS YP_406112.1 82524517 3776667 90163..90831 1 NC_007607.1 putative transposase 90831 3776667 SDY_P111 Shigella dysenteriae Sd197 putative transposase YP_406112.1 90163 D 300267 CDS YP_406113.1 82524518 3776668 complement(90973..91281) 1 NC_007607.1 hypothetical protein 91281 3776668 SDY_P112 Shigella dysenteriae Sd197 hypothetical protein YP_406113.1 90973 R 300267 CDS YP_406114.1 82524519 3776669 complement(91342..91545) 1 NC_007607.1 hypothetical protein 91545 3776669 SDY_P113 Shigella dysenteriae Sd197 hypothetical protein YP_406114.1 91342 R 300267 CDS YP_406115.1 82524520 3776670 91637..92329 1 NC_007607.1 IS186 ORF1 92329 3776670 SDY_P114 Shigella dysenteriae Sd197 IS186 ORF1 YP_406115.1 91637 D 300267 CDS YP_406116.1 82524521 3776671 complement(92370..93083) 1 NC_007607.1 IS600 ORF2 93083 3776671 SDY_P115 Shigella dysenteriae Sd197 IS600 ORF2 YP_406116.1 92370 R 300267 CDS YP_406117.1 82524522 3776672 complement(93224..93526) 1 NC_007607.1 IS600 ORF1 93526 3776672 SDY_P116 Shigella dysenteriae Sd197 IS600 ORF1 YP_406117.1 93224 R 300267 CDS YP_406118.1 82524523 3776673 93565..95079 1 NC_007607.1 hypothetical protein 95079 traD 3776673 traD Shigella dysenteriae Sd197 hypothetical protein YP_406118.1 93565 D 300267 CDS YP_406119.1 82524524 3776674 94961..95374 1 NC_007607.1 hypothetical protein 95374 3776674 SDY_P118 Shigella dysenteriae Sd197 hypothetical protein YP_406119.1 94961 D 300267 CDS YP_406120.1 82524525 3776675 95374..96093 1 NC_007607.1 TrbH 96093 trbH 3776675 trbH Shigella dysenteriae Sd197 TrbH YP_406120.1 95374 D 300267 CDS YP_406121.1 82524526 3776676 complement(95781..96008) 1 NC_007607.1 plasmid maintenance protein 96008 mvpT 3776676 mvpT Shigella dysenteriae Sd197 plasmid maintenance protein YP_406121.1 95781 R 300267 CDS YP_406122.1 82524527 3776677 96090..96509 1 NC_007607.1 oriT nicking and unwinding protein, fragment 96509 3776677 SDY_P121 Shigella dysenteriae Sd197 oriT nicking and unwinding protein, fragment YP_406122.1 96090 D 300267 CDS YP_406123.1 82524528 3776678 96517..100710 1 NC_007607.1 cleaves origin of transfer and unwinds; oriT relaxase; conjugal transfer nickase/helicase TraI 100710 3776678 SDY_P122 Shigella dysenteriae Sd197 conjugal transfer nickase/helicase TraI YP_406123.1 96517 D 300267 CDS YP_406124.1 82524529 3776679 100659..101351 1 NC_007607.1 putative DNA helicase I, fragment 101351 3776679 SDY_P123 Shigella dysenteriae Sd197 putative DNA helicase I, fragment YP_406124.1 100659 D 300267 CDS YP_406125.1 82524530 3776680 101371..102117 1 NC_007607.1 conjugal transfer pilus acetylation protein TraX 102117 traX 3776680 traX Shigella dysenteriae Sd197 conjugal transfer pilus acetylation protein TraX YP_406125.1 101371 D 300267 CDS YP_406126.1 82524531 3776681 102172..102732 1 NC_007607.1 putative fertility inhibition protein; conjugal transfer fertility inhibition protein FinO 102732 finO 3776681 finO Shigella dysenteriae Sd197 conjugal transfer fertility inhibition protein FinO YP_406126.1 102172 D 300267 CDS YP_406127.1 82524532 3776682 102863..103075 1 NC_007607.1 hypothetical protein 103075 yigA 3776682 yigA Shigella dysenteriae Sd197 hypothetical protein YP_406127.1 102863 D 300267 CDS YP_406128.1 82524533 3776683 103259..103561 1 NC_007607.1 hypothetical protein 103561 3776683 SDY_P127 Shigella dysenteriae Sd197 hypothetical protein YP_406128.1 103259 D 300267 CDS YP_406129.1 82524534 3776684 complement(103496..103741) 1 NC_007607.1 IS1 ORF2 103741 insB 3776684 insB Shigella dysenteriae Sd197 IS1 ORF2 YP_406129.1 103496 R 300267 CDS YP_406130.1 82524535 3776685 complement(104009..104221) 1 NC_007607.1 putative iso-IS1 orf 104221 3776685 SDY_P129 Shigella dysenteriae Sd197 putative iso-IS1 orf YP_406130.1 104009 R 300267 CDS YP_406131.1 82524536 3776612 104290..104520 1 NC_007607.1 hypothetical protein 104520 3776612 SDY_P130 Shigella dysenteriae Sd197 hypothetical protein YP_406131.1 104290 D 300267 CDS YP_406132.1 82524537 3776613 104623..104811 1 NC_007607.1 putative regulator 104811 hmo 3776613 hmo Shigella dysenteriae Sd197 putative regulator YP_406132.1 104623 D 300267 CDS YP_406133.1 82524538 3776614 104850..104963 1 NC_007607.1 hypothetical protein 104963 3776614 SDY_P132 Shigella dysenteriae Sd197 hypothetical protein YP_406133.1 104850 D 300267 CDS YP_406134.1 82524539 3776615 complement(104960..105355) 1 NC_007607.1 iso-IS1 ORF2 105355 3776615 SDY_P133 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406134.1 104960 R 300267 CDS YP_406135.1 82524540 3776616 complement(105382..105654) 1 NC_007607.1 iso-IS1 ORF1 105654 3776616 SDY_P134 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406135.1 105382 R 300267 CDS YP_406136.1 82524541 3776617 105714..106214 1 NC_007607.1 hypothetical protein 106214 yihA 3776617 yihA Shigella dysenteriae Sd197 hypothetical protein YP_406136.1 105714 D 300267 CDS YP_406137.1 82524542 3776618 106454..106714 1 NC_007607.1 replication protein 106714 repB 3776618 repB Shigella dysenteriae Sd197 replication protein YP_406137.1 106454 D 300267 CDS YP_406138.1 82524543 3776619 107005..107862 1 NC_007607.1 RepA; replication protein 107862 repA 3776619 repA Shigella dysenteriae Sd197 replication protein YP_406138.1 107005 D 300267 CDS YP_406139.1 82524544 3776620 108605..108700 1 NC_007607.1 hypothetical protein 108700 3776620 SDY_P138 Shigella dysenteriae Sd197 hypothetical protein YP_406139.1 108605 D 300267 CDS YP_406140.1 82524545 3776621 complement(108972..110180) 1 NC_007607.1 IS1294 transposase 110180 3776621 SDY_P139 Shigella dysenteriae Sd197 IS1294 transposase YP_406140.1 108972 R 300267 CDS YP_406141.1 82524547 3776623 complement(110161..110433) 1 NC_007607.1 hypothetical protein 110433 3776623 SDY_P141 Shigella dysenteriae Sd197 hypothetical protein YP_406141.1 110161 R 300267 CDS YP_406142.1 82524546 3776622 110427..111971 1 NC_007607.1 invasion plasmid antigen, fragment 111971 ipaH 3776622 ipaH Shigella dysenteriae Sd197 invasion plasmid antigen, fragment YP_406142.1 110427 D 300267 CDS YP_406143.1 82524548 3776624 complement(112011..112199) 1 NC_007607.1 IS600 ORF2 112199 3776624 SDY_P142 Shigella dysenteriae Sd197 IS600 ORF2 YP_406143.1 112011 R 300267 CDS YP_406144.1 82524549 3776625 complement(112235..112537) 1 NC_007607.1 IS600 ORF1 112537 3776625 SDY_P143 Shigella dysenteriae Sd197 IS600 ORF1 YP_406144.1 112235 R 300267 CDS YP_406145.1 82524550 3776626 complement(112605..113087) 1 NC_007607.1 hypothetical protein 113087 3776626 SDY_P144 Shigella dysenteriae Sd197 hypothetical protein YP_406145.1 112605 R 300267 CDS YP_406146.1 82524551 3776627 complement(113078..113368) 1 NC_007607.1 hypothetical protein 113368 3776627 SDY_P145 Shigella dysenteriae Sd197 hypothetical protein YP_406146.1 113078 R 300267 CDS YP_406147.1 82524552 3776628 complement(113794..114456) 1 NC_007607.1 transposase/IS protein 114456 3776628 SDY_P146 Shigella dysenteriae Sd197 transposase/IS protein YP_406147.1 113794 R 300267 CDS YP_406148.1 82524553 3776629 complement(114511..115803) 1 NC_007607.1 IS1294 transposase 115803 3776629 SDY_P147 Shigella dysenteriae Sd197 IS1294 transposase YP_406148.1 114511 R 300267 CDS YP_406149.1 82524554 3776630 complement(115784..116056) 1 NC_007607.1 hypothetical protein 116056 3776630 SDY_P148 Shigella dysenteriae Sd197 hypothetical protein YP_406149.1 115784 R 300267 CDS YP_406150.1 82524555 3776686 complement(116076..116663) 1 NC_007607.1 ISSfl4 ORF1 116663 3776686 SDY_P149 Shigella dysenteriae Sd197 ISSfl4 ORF1 YP_406150.1 116076 R 300267 CDS YP_406151.1 82524556 3776687 complement(116800..116973) 1 NC_007607.1 hypothetical protein 116973 3776687 SDY_P150 Shigella dysenteriae Sd197 hypothetical protein YP_406151.1 116800 R 300267 CDS YP_406152.1 82524557 3776688 117314..118768 1 NC_007607.1 probably secreted by the Mxi-Spa secretion machinery; OspC3 118768 ospC3 3776688 ospC3 Shigella dysenteriae Sd197 OspC3 YP_406152.1 117314 D 300267 CDS YP_406153.1 82524558 3776689 119107..119409 1 NC_007607.1 IS600 ORF1 119409 3776689 SDY_P152 Shigella dysenteriae Sd197 IS600 ORF1 YP_406153.1 119107 D 300267 CDS YP_406154.1 82524559 3776557 119550..120263 1 NC_007607.1 IS600 ORF2 120263 3776557 SDY_P153 Shigella dysenteriae Sd197 IS600 ORF2 YP_406154.1 119550 D 300267 CDS YP_406155.1 82524560 3776558 120388..120630 1 NC_007607.1 IS1353 transposase 120630 3776558 SDY_P154 Shigella dysenteriae Sd197 IS1353 transposase YP_406155.1 120388 D 300267 CDS YP_406156.1 82524561 3776559 120685..121038 1 NC_007607.1 IS1353 transposase 121038 3776559 SDY_P155 Shigella dysenteriae Sd197 IS1353 transposase YP_406156.1 120685 D 300267 CDS YP_406157.1 82524562 3776560 121228..122343 1 NC_007607.1 putative transposase 122343 3776560 SDY_P156 Shigella dysenteriae Sd197 putative transposase YP_406157.1 121228 D 300267 CDS YP_406159.1 82524564 3776562 complement(122432..123628) 1 NC_007607.1 ISSfl2 ORF 123628 3776562 SDY_P158 Shigella dysenteriae Sd197 ISSfl2 ORF YP_406159.1 122432 R 300267 CDS YP_406160.1 82524565 3776563 complement(123820..124746) 1 NC_007607.1 IS100 ORF1 124746 3776563 SDY_P159 Shigella dysenteriae Sd197 IS100 ORF1 YP_406160.1 123820 R 300267 CDS YP_406161.1 82524566 3776564 126261..126944 1 NC_007607.1 invasion plasmid antigen; IpaJ 126944 ipaJ 3776564 ipaJ Shigella dysenteriae Sd197 IpaJ YP_406161.1 126261 D 300267 CDS YP_406162.1 82524567 3776565 complement(127894..128823) 1 NC_007607.1 transcriptional activator required for tanscription of the ipa, mxi, and spa operons; VirB 128823 virB 3776565 virB Shigella dysenteriae Sd197 VirB YP_406162.1 127894 R 300267 CDS YP_406163.1 82524568 3776566 complement(129030..129266) 1 NC_007607.1 putative acyl carrier protein; Acp 129266 acp 3776566 acp Shigella dysenteriae Sd197 Acp YP_406163.1 129030 R 300267 CDS YP_406164.1 82524569 3776567 complement(129270..131171) 1 NC_007607.1 secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells; IpaA 131171 ipaA 3776567 ipaA Shigella dysenteriae Sd197 IpaA YP_406164.1 129270 R 300267 CDS YP_406165.1 82524570 3776568 complement(131180..132178) 1 NC_007607.1 secreted by the Mxi-Spa machinery, required for entry of bacteria into epithelial cells; IpaD 132178 ipaD 3776568 ipaD Shigella dysenteriae Sd197 IpaD YP_406165.1 131180 R 300267 CDS YP_406166.1 82524571 3776569 complement(132229..133320) 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells; IpaC 133320 ipaC 3776569 ipaC Shigella dysenteriae Sd197 IpaC YP_406166.1 132229 R 300267 CDS YP_406167.1 82524572 3776570 complement(133340..135082) 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells; IpaB 135082 ipaB 3776570 ipaB Shigella dysenteriae Sd197 IpaB YP_406167.1 133340 R 300267 CDS YP_406168.1 82524573 3776571 complement(135088..135555) 1 NC_007607.1 cytoplasmic chaperone for IpaB and IpaC; IpgC 135555 ipgC 3776571 ipgC Shigella dysenteriae Sd197 IpgC YP_406168.1 135088 R 300267 CDS YP_406169.1 82524574 3776572 complement(135613..136239) 1 NC_007607.1 secreted by the Mxi-Spa machinery; IpgB1 136239 ipgB1 3776572 ipgB1 Shigella dysenteriae Sd197 IpgB1 YP_406169.1 135613 R 300267 CDS YP_406170.1 82524575 3776525 complement(136255..136644) 1 NC_007607.1 similar to IpgE, putative chaperone; IpgA 136644 ipgA 3776525 ipgA Shigella dysenteriae Sd197 IpgA YP_406170.1 136255 R 300267 CDS YP_406171.1 82524576 3776526 complement(136657..138141) 1 NC_007607.1 invasion protein; IcsB 138141 icsB 3776526 icsB Shigella dysenteriae Sd197 IcsB YP_406171.1 136657 R 300267 CDS YP_406172.1 82524577 3776527 138455..140071 1 NC_007607.1 secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells; IpgD 140071 ipgD 3776527 ipgD Shigella dysenteriae Sd197 IpgD YP_406172.1 138455 D 300267 CDS YP_406173.1 82524578 3776528 140081..140443 1 NC_007607.1 cytoplasmic chaperone for IpgD; IpgE 140443 ipgE 3776528 ipgE Shigella dysenteriae Sd197 IpgE YP_406173.1 140081 D 300267 CDS YP_406174.1 82524579 3776529 140443..140901 1 NC_007607.1 periplasmic protein, similar to the catalytic site of lyzozymes; IpgF 140901 ipgF 3776529 ipgF Shigella dysenteriae Sd197 IpgF YP_406174.1 140443 D 300267 CDS YP_406175.1 82524580 3776530 140910..142025 1 NC_007607.1 component of the Mxi-Spa secretion machinery, contains one transmembrane segment; MxiG 142025 mxiG 3776530 mxiG Shigella dysenteriae Sd197 MxiG YP_406175.1 140910 D 300267 CDS YP_406176.1 82524581 3776531 142033..142284 1 NC_007607.1 component of the Mxi-Spa secretion machinery; MxiH 142284 mxiH 3776531 mxiH Shigella dysenteriae Sd197 MxiH YP_406176.1 142033 D 300267 CDS YP_406177.1 82524582 3776532 142297..142590 1 NC_007607.1 component of the Mxi-Spa secretion machinery; MxiI 142590 mxiI 3776532 mxiI Shigella dysenteriae Sd197 MxiI YP_406177.1 142297 D 300267 CDS YP_406178.1 82524583 3776533 142596..143321 1 NC_007607.1 lipoprotein, component of the Mxi-Spa secretion machinery; MxiJ 143321 mxiJ 3776533 mxiJ Shigella dysenteriae Sd197 MxiJ YP_406178.1 142596 D 300267 CDS YP_406179.1 82524584 3776534 143327..143845 1 NC_007607.1 putative component of the Mxi-Spa secretion machinery; MxiK 143845 mxiK 3776534 mxiK Shigella dysenteriae Sd197 MxiK YP_406179.1 143327 D 300267 CDS YP_406180.1 82524585 3776535 143787..144482 1 NC_007607.1 putative component of the Mxi-Spa secretion machinery; MxiN 144482 mxiN 3776535 mxiN Shigella dysenteriae Sd197 MxiN YP_406180.1 143787 D 300267 CDS YP_406181.1 82524586 3776536 144475..144882 1 NC_007607.1 secreted by and putative component of the Mxi-Spa secretion machinery; MxiL 144882 mxiL 3776536 mxiL Shigella dysenteriae Sd197 MxiL YP_406181.1 144475 D 300267 CDS YP_406182.1 82524587 3776537 144866..145294 1 NC_007607.1 lipoprotein, component of the Mxi-Spa secretion machinery; MxiM 145294 mxiM 3776537 mxiM Shigella dysenteriae Sd197 MxiM YP_406182.1 144866 D 300267 CDS YP_406183.1 82524588 3776538 145424..146056 1 NC_007607.1 similar to transcriptional activators of the AraC family; MxiE 146056 mxiE 3776538 mxiE Shigella dysenteriae Sd197 MxiE YP_406183.1 145424 D 300267 CDS YP_406184.1 82524589 3776539 146043..147743 1 NC_007607.1 outermembrane protein of the secretin family, component of the Mxi-Spa secretion machinery; MxiD 147743 mxiD 3776539 mxiD Shigella dysenteriae Sd197 MxiD YP_406184.1 146043 D 300267 CDS YP_406185.1 82524590 3776540 147822..148829 1 NC_007607.1 secreted by and putative component of the Mxi-Spa secretion machinery, similar to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica); MxiC 148829 mxiC 3776540 mxiC Shigella dysenteriae Sd197 MxiC YP_406185.1 147822 D 300267 CDS YP_406186.1 82524591 3776541 148836..150902 1 NC_007607.1 innermembrane protein, component of the Mxi-Spa secretion machinery; MxiA 150902 mxiA 3776541 mxiA Shigella dysenteriae Sd197 MxiA YP_406186.1 148836 D 300267 CDS YP_406187.1 82524592 3776542 150915..151316 1 NC_007607.1 putative component of the Mxi-Spa secretion machinery; Spa15 151316 spa15 3776542 spa15 Shigella dysenteriae Sd197 Spa15 YP_406187.1 150915 D 300267 CDS YP_406188.1 82524593 3776543 151320..152612 1 NC_007607.1 component of the Mxi-Spa secretion machinery, putative ATPase; Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase; ATP synthase SpaL 152612 spa47 3776543 spa47 Shigella dysenteriae Sd197 ATP synthase SpaL YP_406188.1 151320 D 300267 CDS YP_406189.1 82524594 3776505 152756..153043 1 NC_007607.1 component of the Mxi-Spa secretion machinery; Spa13 153043 spa13 3776505 spa13 Shigella dysenteriae Sd197 Spa13 YP_406189.1 152756 D 300267 CDS YP_406190.1 82524595 3776506 153030..153908 1 NC_007607.1 secreted by and component of the Mxi-Spa machinery; Spa32 153908 spa32 3776506 spa32 Shigella dysenteriae Sd197 Spa32 YP_406190.1 153030 D 300267 CDS YP_406191.1 82524596 3776507 153902..154783 1 NC_007607.1 component of the Mxi-Spa secretion machinery; Spa33 154783 spa33 3776507 spa33 Shigella dysenteriae Sd197 Spa33 YP_406191.1 153902 D 300267 CDS YP_406192.1 82524597 3776508 154788..155438 1 NC_007607.1 component of the Mxi-Spa secretion machinery; part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP 155438 spaP 3776508 spaP Shigella dysenteriae Sd197 surface presentation of antigens protein SpaP YP_406192.1 154788 D 300267 CDS YP_001449235.1 157042764 5563324 155453..155713 1 NC_007607.1 Spa9 155713 spa9 5563324 spa9 Shigella dysenteriae Sd197 Spa9 YP_001449235.1 155453 D 300267 CDS YP_406193.1 82524598 3776509 155713..156483 1 NC_007607.1 component of the Mxi-Spa secretion machinery; Spa29 156483 spa29 3776509 spa29 Shigella dysenteriae Sd197 Spa29 YP_406193.1 155713 D 300267 CDS YP_406194.1 82524599 3776510 156490..157518 1 NC_007607.1 component of the Mxi-Spa secretion machinery; Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; surface presentation of antigens protein SpaS 157518 spa40 3776510 spa40 Shigella dysenteriae Sd197 surface presentation of antigens protein SpaS YP_406194.1 156490 D 300267 CDS YP_406195.1 82524600 3776511 157540..157773 1 NC_007607.1 hypothetical protein 157773 spa-orf10 3776511 spa-orf10 Shigella dysenteriae Sd197 hypothetical protein YP_406195.1 157540 D 300267 CDS YP_406196.1 82524601 3776512 complement(158350..158970) 1 NC_007607.1 IS600 ORF2 158970 3776512 SDY_P195 Shigella dysenteriae Sd197 IS600 ORF2 YP_406196.1 158350 R 300267 CDS YP_406197.1 82524602 3776513 complement(159179..159607) 1 NC_007607.1 IS3 ORF2 159607 3776513 SDY_P196 Shigella dysenteriae Sd197 IS3 ORF2 YP_406197.1 159179 R 300267 CDS YP_406198.1 82524603 3776514 complement(159579..159797) 1 NC_007607.1 IS3 ORF1 159797 3776514 SDY_P197 Shigella dysenteriae Sd197 IS3 ORF1 YP_406198.1 159579 R 300267 CDS YP_406199.1 82524604 3776515 complement(160815..161591) 1 NC_007607.1 hypothetical protein 161591 3776515 SDY_P198 Shigella dysenteriae Sd197 hypothetical protein YP_406199.1 160815 R 300267 CDS YP_406200.1 82524605 3776516 complement(162115..162315) 1 NC_007607.1 putative transposase 162315 3776516 SDY_P199 Shigella dysenteriae Sd197 putative transposase YP_406200.1 162115 R 300267 CDS YP_406201.1 82524606 3776517 complement(162252..162452) 1 NC_007607.1 putative transposase 162452 3776517 SDY_P200 Shigella dysenteriae Sd197 putative transposase YP_406201.1 162252 R 300267 CDS YP_406202.1 82524607 3776518 complement(162546..162923) 1 NC_007607.1 putative transposase 162923 3776518 SDY_P201 Shigella dysenteriae Sd197 putative transposase YP_406202.1 162546 R 300267 CDS YP_406203.1 82524608 3776519 complement(163141..163461) 1 NC_007607.1 hypothetical protein 163461 3776519 SDY_P202 Shigella dysenteriae Sd197 hypothetical protein YP_406203.1 163141 R 300267 CDS YP_406204.1 82524609 3776520 163622..164269 1 NC_007607.1 IS629 ORF2 164269 3776520 SDY_P203 Shigella dysenteriae Sd197 IS629 ORF2 YP_406204.1 163622 D 300267 CDS YP_406205.1 82524610 3776521 complement(164747..165148) 1 NC_007607.1 IS91 orf 165148 3776521 SDY_P204 Shigella dysenteriae Sd197 IS91 orf YP_406205.1 164747 R 300267 CDS YP_406206.1 82524611 3776522 complement(165211..165468) 1 NC_007607.1 putative IS91 ORF2 165468 3776522 SDY_P205 Shigella dysenteriae Sd197 putative IS91 ORF2 YP_406206.1 165211 R 300267 CDS YP_406207.1 82524612 3776523 complement(166459..166659) 1 NC_007607.1 putative reverse transcriptase, fragment 166659 3776523 SDY_P206 Shigella dysenteriae Sd197 putative reverse transcriptase, fragment YP_406207.1 166459 R 300267 CDS YP_406208.1 82524613 3776524 complement(166574..166816) 1 NC_007607.1 IS3 ORF2 166816 3776524 SDY_P207 Shigella dysenteriae Sd197 IS3 ORF2 YP_406208.1 166574 R 300267 CDS YP_406209.1 82524614 3776488 complement(166789..167112) 1 NC_007607.1 IS629 ORF2 167112 3776488 SDY_P208 Shigella dysenteriae Sd197 IS629 ORF2 YP_406209.1 166789 R 300267 CDS YP_406210.1 82524616 3776490 complement(166995..167351) 1 NC_007607.1 IS629 ORF2 167351 3776490 SDY_P210 Shigella dysenteriae Sd197 IS629 ORF2 YP_406210.1 166995 R 300267 CDS YP_406211.1 82524615 3776489 167342..167593 1 NC_007607.1 hypothetical protein 167593 3776489 SDY_P209 Shigella dysenteriae Sd197 hypothetical protein YP_406211.1 167342 D 300267 CDS YP_406212.1 82524617 3776491 complement(167852..169054) 1 NC_007607.1 secreted by the Mxi-Spa secretion machinery; VirA 169054 virA 3776491 virA Shigella dysenteriae Sd197 VirA YP_406212.1 167852 R 300267 CDS YP_406213.1 82524618 3776492 complement(169389..169784) 1 NC_007607.1 iso-IS1 ORF2 169784 3776492 SDY_P212 Shigella dysenteriae Sd197 iso-IS1 ORF2 YP_406213.1 169389 R 300267 CDS YP_406214.1 82524619 3776493 complement(169811..170083) 1 NC_007607.1 iso-IS1 ORF1 170083 3776493 SDY_P213 Shigella dysenteriae Sd197 iso-IS1 ORF1 YP_406214.1 169811 R 300267 CDS YP_406215.1 82524620 3776494 170357..173665 1 NC_007607.1 VirG; outermembrane protein exposed to the bacterial surface by a C-terminal autotransporter domain and involved in the movement of intracellular bacteria by binding to N-WASP; IcsA 173665 icsA 3776494 icsA Shigella dysenteriae Sd197 IcsA YP_406215.1 170357 D 300267 CDS YP_406216.2 161986649 3776495 complement(173891..174796) 1 NC_007607.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 174796 3776495 SDY_P215 Shigella dysenteriae Sd197 insertion element IS2 transposase InsD YP_406216.2 173891 R 300267 CDS YP_406217.1 82524622 3776496 complement(174754..175119) 1 NC_007607.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 175119 3776496 SDY_P216 Shigella dysenteriae Sd197 insertion sequence 2 OrfA protein YP_406217.1 174754 R 300267 CDS YP_406218.1 82524623 3776497 175253..175876 1 NC_007607.1 IS629 ORF2 175876 3776497 SDY_P217 Shigella dysenteriae Sd197 IS629 ORF2 YP_406218.1 175253 D 300267 CDS YP_406219.1 82524624 3776498 176003..176233 1 NC_007607.1 hypothetical protein 176233 3776498 SDY_P218 Shigella dysenteriae Sd197 hypothetical protein YP_406219.1 176003 D 300267 CDS YP_406220.1 82524625 3776499 176278..176538 1 NC_007607.1 replication protein 176538 repB 3776499 repB Shigella dysenteriae Sd197 replication protein YP_406220.1 176278 D 300267 CDS YP_406221.1 82524626 3776500 176840..177697 1 NC_007607.1 RepA; replication protein 177697 repA 3776500 repA Shigella dysenteriae Sd197 replication protein YP_406221.1 176840 D 300267 CDS YP_406222.1 82524627 3776501 complement(179127..179837) 1 NC_007607.1 hypothetical protein 179837 3776501 SDY_P221 Shigella dysenteriae Sd197 hypothetical protein YP_406222.1 179127 R 300267 CDS YP_406223.1 82524628 3776502 179875..180027 1 NC_007607.1 IS3 ORF2 180027 3776502 SDY_P222 Shigella dysenteriae Sd197 IS3 ORF2 YP_406223.1 179875 D 300267 CDS YP_406224.1 82524629 3776503 complement(180309..180446) 1 NC_007607.1 hypothetical protein 180446 3776503 SDY_P223 Shigella dysenteriae Sd197 hypothetical protein YP_406224.1 180309 R 300267 CDS YP_406225.2 161986648 3776504 181408..182355 1 NC_007607.1 SopA; outermembrane protease of the OmpP family, involved in cleavage of surface exposed IcsA; outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA; outer membrane protease 182355 icsP 3776504 icsP Shigella dysenteriae Sd197 outer membrane protease YP_406225.2 181408 D 300267 CDS YP_001139944.1 145294017 4991496 741..1697 1 NC_009344.1 replication initiation protein; hypothetical protein 1697 repA 4991496 repA Shigella dysenteriae Sd197 hypothetical protein YP_001139944.1 741 D 300267 CDS YP_001139945.1 145294018 4991497 2073..2348 1 NC_009344.1 IS1 ORF1; hypothetical protein 2348 insA 4991497 insA Shigella dysenteriae Sd197 hypothetical protein YP_001139945.1 2073 D 300267 CDS YP_001139946.1 145294019 4991498 2393..2770 1 NC_009344.1 IS1 ORF2; hypothetical protein 2770 insB 4991498 insB Shigella dysenteriae Sd197 hypothetical protein YP_001139946.1 2393 D 300267 CDS YP_001139947.1 145294020 4991499 complement(2979..4112) 1 NC_009344.1 glycosyltransferase; RfpB 4112 rfpB 4991499 rfpB Shigella dysenteriae Sd197 RfpB YP_001139947.1 2979 R 300267 CDS YP_001139948.1 145294021 4991500 complement(4330..4920) 1 NC_009344.1 glycosyltransferase; RfpA 4920 rfpA 4991500 rfpA Shigella dysenteriae Sd197 RfpA YP_001139948.1 4330 R 300267 CDS YP_001139949.1 145294022 4991501 complement(5327..6097) 1 NC_009344.1 hypothetical protein 6097 4991501 SDY_PA06 Shigella dysenteriae Sd197 hypothetical protein YP_001139949.1 5327 R 300267 CDS YP_001139950.1 145294023 4991502 7225..7497 1 NC_009344.1 hypothetical protein 7497 4991502 SDY_PA07 Shigella dysenteriae Sd197 hypothetical protein YP_001139950.1 7225 D 300267 CDS YP_001139951.1 145294024 4991503 7478..8686 1 NC_009344.1 IS1294 transposase 8686 4991503 SDY_PA08 Shigella dysenteriae Sd197 IS1294 transposase YP_001139951.1 7478 D 300267 CDS