-- dump date   	20140620_065109
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_401730.1	homoserine dehydrogenase I; multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_401731.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_401732.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_401734.1	Code: S; COG: COG3022
YP_401736.1	Code: G; COG: COG0176
YP_401737.1	required for the efficient incorporation of molybdate into molybdoproteins; forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_401738.1	Code: S; COG: COG1584
YP_401739.1	Code: S; COG: COG4735
YP_401741.1	DNA biosynthesis; autoregulated heat shock proteins; heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_401742.1	chaperone with DnaK; ''chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion''
YP_401743.1	interferes with membrane function when in excess
YP_401746.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_401747.1	Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC
YP_401750.1	Code: L; COG: COG1662
YP_401751.1	Code: L; COG: COG1662
YP_401752.1	Code: L; COG: COG3677
YP_401753.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_401754.2	Code: S; COG: COG3112
YP_401755.1	S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_401756.1	putrescine aminopropyltransferase; catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_401758.1	laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification
YP_401759.1	Code: L; COG: COG3677
YP_401760.1	Code: L; COG: COG1662
YP_401761.2	Code: F; COG: COG0634
YP_401762.1	catalyzes the interconversion of bicarbonate and carbon dioxide
YP_401763.1	Code: V; COG: COG1131
YP_401764.1	Code: V; COG: COG0842
YP_401765.1	Code: G; COG: COG2893
YP_401768.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_401769.1	Code: S; COG: COG5464
YP_401770.1	Code: L; COG: COG3677
YP_401771.1	Code: L; COG: COG1662
YP_401772.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_401774.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_401775.1	''IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme''
YP_401776.1	SPase II; lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_401777.1	rotamase; Code: O; COG: COG1047
YP_401778.1	involved in penicillin tolerance; catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_401779.1	catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides
YP_401780.1	''catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis''
YP_401781.1	small subunit; catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_401782.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_401784.1	involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities
YP_401785.1	catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
YP_401786.1	Code: IQ; COG: COG0318
YP_401787.1	''catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine''
YP_401788.1	catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA
YP_401789.1	catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism
YP_401790.2	probable flavoprotein subunit; carnitine metabolism; ''required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase''
YP_401791.1	probable flavoprotein subunit; carnitine metabolism; involved in electron transfer during carnitine metabolism
YP_401793.1	Code: C; COG: COG2440
YP_401796.1	''Required for full activity of KefC, a potassium-proton antiporter''
YP_401797.1	Code: P; COG: COG1226
YP_401798.1	trimethoprim resistance; catalyzes the reduction of dihydrofolate to tetrahydrofolate
YP_401799.1	Code: R; COG: COG5302
YP_401801.1	''hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP''
YP_401802.1	protein associated with Co2+ and Mg2+ efflux
YP_401803.1	rRNA dimethyltransferase; catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_401804.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_401805.1	''Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB''
YP_401806.1	determines N-hexane tolerance and is involved in outer membrane permeability
YP_401807.1	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_401809.1	catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs
YP_401810.1	''transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA''
YP_401811.1	Code: L; COG: COG1662
YP_401812.1	Code: L; COG: COG3677
YP_401813.1	Code: L; COG: COG1662
YP_401814.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_401815.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_401816.1	catalyzes the phosphorylation of ribulose to ribulose 5-phosphate
YP_401817.1	Code: S; COG: COG0586
YP_401818.1	with TbpA and ThiP is part of the thiamine and TPP transport system
YP_401819.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_401820.1	part of the thiamine and TPP transport system tbpA-thiPQ
YP_401821.1	Code: L; COG: COG3677
YP_401822.1	activates sgrS under glucose-phosphate stress conditions
YP_401823.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_401824.1	dehydratase subunit; ''dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate''
YP_401825.2	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_401826.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_401827.1	involved in attenuation control of the leuABCD operon in leucine biosynthesis
YP_401830.1	Code: L; COG: COG3677
YP_401831.1	''catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive''
YP_401832.1	valine sensitive; ''with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit''
YP_401834.1	binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism
YP_401835.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_401836.1	Code: M; COG: COG0275
YP_401837.1	ingrowth of wall at septum; membrane bound cell division protein at septum containing leucine zipper motif
YP_401838.1	septum formation; peptidoglycan synthetase; Code: M; COG: COG0768
YP_401839.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_401840.1	Code: M; COG: COG0770
YP_401841.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_401842.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_401843.1	cell division; membrane protein involved in shape determination; integral membrane protein involved in stabilizing FstZ ring during cell division
YP_401844.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_401845.1	L-alanine adding enzyme; Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_401846.1	affects cell division; D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_401847.1	ingrowth of wall at septum; involved in septum formation
YP_401848.1	septation process, complexes with FtsZ; associated with junctions of inner and outer membranes; ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane
YP_401849.1	cell division; forms circumferential ring; ''GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function''
YP_401850.1	lipid A biosynthesis; zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_401851.2	secM translational pause allows for the initiation of secA translation
YP_401852.1	secretion protein; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_401853.1	prefers dGTP; causes AT-GC transversions; Code: LR; COG: COG0494
YP_401855.1	Code: S; COG: COG3024
YP_401856.1	Code: S; COG: COG4582
YP_401857.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_401858.1	catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate
YP_401861.1	Code: NU; COG: COG4969
YP_401862.1	''catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide''
YP_401863.1	Code: V; COG: COG3023
YP_401864.1	involved in regulation of beta-lactamase; signaling protein
YP_401865.1	Code: E; COG: COG1113
YP_401866.1	activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex
YP_401867.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_401868.1	E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains
YP_401869.1	component of 2-oxodehydrogenase and pyruvate complexes; L-protein of glycine cleavage complex; E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_401872.1	Code: L; COG: COG1662
YP_401873.1	Code: L; COG: COG3677
YP_401875.1	Code: L; COG: COG1662
YP_401877.1	''catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate''
YP_401878.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_401879.1	Code: L; COG: COG1662
YP_401880.1	Code: L; COG: COG1662
YP_401881.1	''catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP''
YP_401882.2	Polymerase that creates the 3' poly(A) tail found in some mRNA's
YP_401883.2	''this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu''
YP_401884.1	Code: T; COG: COG1734
YP_401885.1	Regulatory factor involved in maltose metabolism
YP_401886.1	Code: J; COG: COG1514
YP_401887.1	penicillin-binding protein 1B; ''bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell''
YP_401888.1	involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein
YP_401889.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter
YP_401890.1	Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores
YP_401891.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome
YP_401892.1	aminomutase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_401893.1	Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation
YP_401894.1	essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors
YP_401895.1	Code: S; COG: COG2860
YP_401896.1	solute binding component of the vitamin B12 transport system BtuCDF
YP_401897.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_401898.1	Code: L; COG: COG1662
YP_401899.1	heat shock protein HtrA; protease Do; required at high temperature; degrades damaged proteins
YP_401903.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_401904.1	uridylyltransferase acts on regulator of glnA; catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein
YP_401905.1	''catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn''
YP_401906.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_401907.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_401908.1	Catalyzes the phosphorylation of UMP to UDP
YP_401909.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_401910.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_401911.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_401912.2	catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate
YP_401913.1	catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response
YP_401914.1	''part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins''
YP_401915.1	located in outer membrane or nucleoid; Code: M; COG: COG2825
YP_401916.1	third step of endotoxin (lipidA) synthesis; adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_401917.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_401918.1	lipid A biosynthesis; catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_401919.1	lipid A biosynthesis, penultimate step; ''catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM''
YP_401920.1	degrades RNA of DNA-RNA hybrids; RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_401921.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_401922.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_401923.1	Code: L; COG: COG3677
YP_401924.1	Code: L; COG: COG1662
YP_401925.1	Code: E; COG: COG0346
YP_401926.1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase
YP_401927.1	Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination
YP_401929.1	Code: S; COG: COG4681
YP_401930.1	Code: J; COG: COG1186
YP_401931.1	lipoprotein; Code: MP; COG: COG3015
YP_401933.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_401934.1	Code: S; COG: COG1720
YP_401935.1	interacts with RcsB
YP_401936.1	Code: P; COG: COG1464
YP_401937.1	part of the MetNIQ methionine uptake system
YP_401938.1	part of the metNIQ transport system for methionine
YP_401939.1	''Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate''
YP_401940.1	''catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid''
YP_401941.1	Code: K; COG: COG0583
YP_401942.1	Code: S; COG: COG3021
YP_401944.1	cytochrome c552; ''catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall''
YP_401945.1	catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione
YP_401946.1	Code: QR; COG: COG0500
YP_401947.1	degrades RNA of DNA-RNA hybrids, participates in DNA replication; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_401948.1	3'-5' exonuclease of DNA polymerase III
YP_401949.1	Code: L; COG: COG1662
YP_401950.1	Code: L; COG: COG3677
YP_401955.2	Code: L; COG: COG1662
YP_401958.1	Code: R; COG: COG0388
YP_401959.1	inactivates vertebrate C-type lysozyme
YP_401960.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_401961.1	Code: R; COG: COG0121
YP_401962.1	Code: S; COG: COG3034
YP_401963.1	Code: S; COG: COG3041
YP_401964.1	Code: L; COG: COG3077
YP_401965.1	Code: M; COG: COG0791
YP_401966.1	Code: L; COG: COG1943
YP_401967.1	Code: L; COG: COG1662
YP_401968.1	Code: NU; COG: COG3121
YP_401969.1	Code: L; COG: COG3677
YP_401970.1	Code: L; COG: COG1662
YP_401971.1	Code: L; COG: COG1662
YP_401972.1	Code: L; COG: COG1662
YP_401977.1	involved in protein transport; multicopy suppressor of dominant negative ftsH mutations
YP_401980.1	Code: L; COG: COG1662
YP_401981.1	Code: L; COG: COG3677
YP_401982.1	phosphoribosylaminoimidazole carboxylase; With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_401983.1	phosphoribosylaminoimidazole carboxylase; Code: F; COG: COG0041
YP_401984.1	''catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine''
YP_401985.1	rotamase B; Code: O; COG: COG0652
YP_401986.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_401988.1	Code: S; COG: COG2501
YP_401989.1	5,10-methylene-tetrahydrofolate cyclohydrolase; Code: H; COG: COG0190
YP_401990.1	Code: L; COG: COG3677
YP_401991.1	Code: L; COG: COG2801
YP_401992.1	Code: L; COG: COG2963
YP_401994.1	''YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His''
YP_401995.1	Code: R; COG: COG0824
YP_401998.1	Code: L; COG: COG1555
YP_401999.1	Code: O; COG: COG0760
YP_402000.1	NS1 (HU-1); histone-like DNA-binding protein
YP_402001.1	heat shock K-protein; Code: O; COG: COG0466
YP_402002.1	chaperone; binds and unfolds substrates as part of the ClpXP protease
YP_402003.1	heat shock protein F21.5; ''hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates''
YP_402004.1	a molecular chaperone involved in cell division; Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_402006.2	''positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress''
YP_402007.2	Code: M; COG: COG3056
YP_402008.1	in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein
YP_402009.1	Code: L; COG: COG1662
YP_402011.1	Code: GEPR; COG: COG0477
YP_402012.2	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_402013.1	involved in thiamin biosynthesis; alternative pyrimidine biosynthesis; ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_402014.1	Code: R; COG: COG0693
YP_402015.1	Required for the synthesis of the thiazole moiety
YP_402016.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_402017.1	farnesyldiphosphate synthase; Code: H; COG: COG0142
YP_402018.1	flavoprotein; catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_402019.1	Code: C; COG: COG0667
YP_402020.1	Code: L; COG: COG1662
YP_402022.1	Code: L; COG: COG1662
YP_402024.1	hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate
YP_402025.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_402026.1	transcription termination; L factor; Regulates rRNA biosynthesis by transcriptional antitermination
YP_402027.1	''RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not''
YP_402028.1	in pathway of riboflavin synthesis; ''riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil''
YP_402029.1	Code: K; COG: COG1327
YP_402031.1	receptor of phage T6 and colicin K; Code: M; COG: COG3248
YP_402032.1	Code: V; COG: COG1403
YP_402033.1	''forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF''
YP_402034.1	protein secretion; membrane protein, part of the channel; ''part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane''
YP_402035.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_402036.1	''Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)''
YP_402037.1	synthesis of queuine in tRNA; Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_402042.1	''cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation''
YP_402043.1	Code: E; COG: COG1114
YP_402044.1	sensor is PhoR (or CreC); two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB
YP_402045.1	Code: L; COG: COG3385
YP_402046.1	with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity
YP_402047.2	Code: L; COG: COG1662
YP_402048.2	catalyzes phosphorylation of fructose; cytosolic enzyme
YP_402049.1	Required for efficient pilin antigenic variation
YP_402051.1	Code: L; COG: COG1662
YP_402053.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402054.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402056.1	Code: S; COG: COG3123
YP_402057.1	regulated by aroR
YP_402059.1	type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_402060.2	Code: S; COG: COG1671
YP_402061.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_402062.1	''catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis''
YP_402063.1	Code: L; COG: COG2801
YP_402065.1	Code: L; COG: COG1662
YP_402067.1	Code: L; COG: COG1662
YP_402068.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_402072.1	possible envelop protein; ''in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope''
YP_402073.1	this protein has no known enzymatic function
YP_402075.1	Code: L; COG: COG1662
YP_402077.1	Code: L; COG: COG1662
YP_402078.1	Code: L; COG: COG3677
YP_402079.2	Code: L; COG: COG1662
YP_402081.1	transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer
YP_402083.1	Code: L; COG: COG2963
YP_402084.1	Code: L; COG: COG2801
YP_402085.1	Code: R; COG: COG0561
YP_402086.1	Code: K; COG: COG1522
YP_402087.1	Code: V; COG: COG1132
YP_402088.1	Code: V; COG: COG1132
YP_402089.1	''indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.''
YP_402090.1	Code: P; COG: COG0004
YP_402091.1	Code: I; COG: COG1946
YP_402092.1	Code: L; COG: COG3695
YP_402093.1	Code: S; COG: COG5507
YP_402094.1	Code: T; COG: COG4943
YP_402095.1	Code: L; COG: COG3677
YP_402096.1	Code: R; COG: COG3960
YP_402097.1	regulates operons involved in the utilization of allantoin
YP_402098.1	catalyzes the formation of glyoxylate from (S)-ureidoglycolate
YP_402099.1	activator of the allDC-ylbA operon involved in allantoin utilization
YP_402100.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_402102.1	Code: L; COG: COG3677
YP_402103.1	Code: L; COG: COG1662
YP_402104.1	Code: Q; COG: COG4181
YP_402105.1	also functions as protease I; Code: E; COG: COG2755
YP_402106.1	Code: IQR; COG: COG1028
YP_402107.1	Code: O; COG: COG3118
YP_402108.1	Code: R; COG: COG0390
YP_402109.1	Code: R; COG: COG4619
YP_402110.1	Code: O; COG: COG0330
YP_402111.1	Code: OU; COG: COG1585
YP_402114.1	Code: L; COG: COG1662
YP_402115.1	activator of copper-responsive regulon genes
YP_402116.1	Code: M; COG: COG0845
YP_402117.1	Code: V; COG: COG2274
YP_402127.1	Code: L; COG: COG1662
YP_402130.1	Code: L; COG: COG3677
YP_402132.1	Code: E; COG: COG0531
YP_402133.1	Code: P; COG: COG2217
YP_402134.1	Code: R; COG: COG3093
YP_402135.1	Code: S; COG: COG3735
YP_402136.1	Code: S; COG: COG2606
YP_402137.1	5'-nucleotidase; ''catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides''
YP_402138.1	Code: L; COG: COG3385
YP_402139.1	YbaL; member of the CPA-2 family of antiporters; uncharacterized protein
YP_402140.1	Code: G; COG: COG0524
YP_402141.1	final enzyme of heme biosynthesis; protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_402142.1	adenylate kinase activity; pleiotropic effects on glycerol-3-phosphate acyltransferase activity; essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_402143.1	heat shock protein C 62.5; molecular chaperone
YP_402144.1	''involved in a recombinational process of DNA repair, independent of the recBC complex''
YP_402145.1	Code: S; COG: COG0718
YP_402146.1	DNA elongation factor III; ''catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA''
YP_402147.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_402148.1	Code: S; COG: COG2832
YP_402149.1	''PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks''
YP_402151.1	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_402152.1	regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine
YP_402153.1	Code: M; COG: COG0845
YP_402154.1	Code: V; COG: COG0841
YP_402156.1	with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins
YP_402157.1	Code: R; COG: COG0110
YP_402160.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402161.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402162.1	Code: L; COG: COG1662
YP_402163.1	Code: L; COG: COG3677
YP_402164.1	Code: L; COG: COG2963
YP_402167.1	Code: L; COG: COG1662
YP_402169.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_402170.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_402171.1	Code: L; COG: COG3677
YP_402172.1	Code: L; COG: COG1662
YP_402173.1	transcriptional regulator of cryptic csgA gene for curli surface fibers; involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS
YP_402174.1	forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation
YP_402175.1	''catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively''
YP_402176.1	peptidase D; Code: E; COG: COG2195
YP_402178.1	Code: S; COG: COG1690
YP_402179.1	tRNA synthetase; involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_402180.1	Code: N; COG: COG1360
YP_402181.1	Code: N; COG: COG1291
YP_402182.1	Code: L; COG: COG1662
YP_402183.1	Code: L; COG: COG3677
YP_402185.1	Code: E; COG: COG1113
YP_402186.1	Code: M; COG: COG0668
YP_402187.1	''catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive''
YP_402188.1	Code: S; COG: COG2315
YP_402190.1	ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity
YP_402191.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402192.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402195.1	Code: L; COG: COG3677
YP_402196.1	Code: L; COG: COG1662
YP_402197.1	porphobilinogen synthase; catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_402198.1	2-oxoglutarate-dependent; catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers
YP_402199.1	Code: P; COG: COG0600
YP_402200.1	Part of the ABC transporter complex tauABC involved in taurine import
YP_402201.1	with TauB and TauC is responsible for taurine uptake.
YP_402202.1	hexosephosphate transport; Code: TK; COG: COG2197
YP_402206.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402207.1	Code: Q; COG: COG2977
YP_402208.1	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_402209.1	Code: P; COG: COG2382
YP_402210.1	Code: S; COG: COG3251
YP_402211.1	may be part of enterobactin synthase as component F; ''with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin''
YP_402213.1	Code: L; COG: COG3677
YP_402214.1	enterochelin transport; part of the ferric enterobactin transport system; necessary for enetrobactin uptake
YP_402215.1	with FepBDE is involved in the transport of ferric enterobactin
YP_402216.1	with FepBCD is involved in the transport of ferric enterobactin
YP_402217.1	enterochelin transport; with FepBCG is involved in the transport of ferric enterobactin
YP_402218.1	protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters
YP_402219.1	enterochelin binding protein; periplasmic component; with FepCDG is involved in the transport of ferric enterobactin
YP_402220.1	enterochelin biosynthesis; Code: HQ; COG: COG1169
YP_402221.1	''bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate''
YP_402222.1	isochroismatase; Code: Q; COG: COG1535
YP_402223.1	enterochelin biosynthesis; ''catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin''
YP_402224.1	Code: Q; COG: COG2050
YP_402225.1	Code: S; COG: COG2879
YP_402226.1	member of the iron-containing alcohol dehydrogenase; unknown function
YP_402230.1	Code: L; COG: COG2963
YP_402231.1	Code: L; COG: COG2801
YP_402232.1	Code: R; COG: COG3969
YP_402233.1	Code: L; COG: COG1662
YP_402234.1	detoxification of hydroperoxides; with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate
YP_402235.1	detoxification of hydroperoxides; Code: O; COG: COG3634
YP_402236.1	Code: T; COG: COG0589
YP_402237.1	Code: L; COG: COG3677
YP_402238.1	Code: L; COG: COG1662
YP_402239.1	catalyzes the transfer of palmitate to lipid A
YP_402240.1	member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator
YP_402241.1	Code: D; COG: COG0239
YP_402243.1	TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_402244.1	possible sulfur insertion; catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_402245.1	Code: K; COG: COG0583
YP_402246.2	lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism
YP_402247.1	Code: S; COG: COG2921
YP_402248.1	penicillin-binding protein 5; penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
YP_402249.1	Code: M; COG: COG0797
YP_402250.1	sensitivity to radiation and drugs; Code: D; COG: COG0772
YP_402251.1	cell elongation, e phase; peptidoglycan synthetase; Code: M; COG: COG0768
YP_402252.1	SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_402253.2	Code: S; COG: COG0799
YP_402254.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_402255.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_402256.1	rare lipoprotein B; involved in the assembly of LPS in the outer membrane
YP_402257.1	''leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase''
YP_402258.1	Code: L; COG: COG2963
YP_402259.1	Code: L; COG: COG2801
YP_402261.1	Code: R; COG: COG0790
YP_402262.1	Code: L; COG: COG1662
YP_402263.1	Code: L; COG: COG3677
YP_402274.1	Code: L; COG: COG2963
YP_402275.1	Code: L; COG: COG2963
YP_402276.1	Code: L; COG: COG2801
YP_402277.1	Code: E; COG: COG0765
YP_402278.1	Code: L; COG: COG2963
YP_402279.1	Code: L; COG: COG2801
YP_402280.1	Code: ET; COG: COG0834
YP_402281.1	copper homeostasis protein; inner membrane; Transfers the fatty acyl group on membrane lipoproteins
YP_402282.1	Code: P; COG: COG4535
YP_402283.1	Code: R; COG: COG0319
YP_402284.1	Code: T; COG: COG1702
YP_402285.1	Code: J; COG: COG0621
YP_402286.1	''catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q''
YP_402290.1	''functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP''
YP_402291.1	Code: G; COG: COG0647
YP_402292.1	transcriptional repressor of nag operon; Code: KG; COG: COG1940
YP_402293.1	catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate
YP_402294.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_402295.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_402296.1	''catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''
YP_402297.1	Code: L; COG: COG1662
YP_402298.1	Code: L; COG: COG3677
YP_402299.1	Code: L; COG: COG1662
YP_402301.1	Code: L; COG: COG3677
YP_402305.1	negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer
YP_402306.1	''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''
YP_402308.1	Code: R; COG: COG0596
YP_402309.1	negative modulator of the initiation of chromosome replication
YP_402310.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_402311.1	transcriptional effector; response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport
YP_402312.1	''One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex''
YP_402315.1	Code: M; COG: COG3209
YP_402316.1	Code: L; COG: COG1662
YP_402319.1	Code: L; COG: COG1662
YP_402321.1	Code: S; COG: COG3272
YP_402322.1	photoreactivation; UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent
YP_402323.1	Code: S; COG: COG0327
YP_402324.1	Code: E; COG: COG2049
YP_402325.1	Code: E; COG: COG1984
YP_402326.1	Code: R; COG: COG1540
YP_402327.1	5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity
YP_402328.1	Code: R; COG: COG3180
YP_402330.1	Code: NU; COG: COG3121
YP_402331.1	Code: L; COG: COG1662
YP_402332.1	Code: NU; COG: COG3539
YP_402333.1	Code: L; COG: COG1662
YP_402334.1	Code: L; COG: COG3677
YP_402335.1	''type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH''
YP_402336.1	cytochrome b556; Code: C; COG: COG2009
YP_402337.1	Code: C; COG: COG2142
YP_402338.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_402339.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_402341.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_402342.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_402343.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_402344.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_402345.1	Code: L; COG: COG3677
YP_402346.1	Code: L; COG: COG1662
YP_402347.1	Code: L; COG: COG3677
YP_402348.1	Code: L; COG: COG1662
YP_402350.1	Code: E; COG: COG3799
YP_402351.1	Code: E; COG: COG4865
YP_402353.1	converts methylaspartate to L-glutamate
YP_402357.1	Code: C; COG: COG1271
YP_402358.1	Code: C; COG: COG1294
YP_402359.1	Code: S; COG: COG4890
YP_402360.1	Code: S; COG: COG3790
YP_402361.1	catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components
YP_402362.1	membrane-spanning; maintains integrity of cell envelope; tolerance to group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_402363.1	involved in the tonB-independent uptake of group A colicins; membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_402364.1	required for outer membrane integrity; ''inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins''
YP_402365.1	involved in the tonb-independent uptake of group A colicins; forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_402366.1	Code: M; COG: COG2885
YP_402367.1	periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity
YP_402368.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_402369.1	Code: H; COG: COG3201
YP_402370.1	involved in zinc efflux across the cytoplasmic membrane
YP_402375.1	DAHP synthetase; phenylalanine repressible; ''catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive''
YP_402376.1	Code: G; COG: COG0588
YP_402377.1	mutarotase; ''catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose''
YP_402378.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_402379.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_402380.1	Code: M; COG: COG1087
YP_402381.1	contains 2 ATP-binding cassettes; involved in the transport of molybdenum
YP_402382.1	represses the modABCD operon and activates the moaABCD and napFDAGHBC operons
YP_402384.1	permease; with ModCB is involved in the high-affinity transport of molybdate
YP_402385.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_402386.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_402388.1	Code: L; COG: COG2963
YP_402389.1	Code: L; COG: COG1662
YP_402393.1	Code: L; COG: COG2963
YP_402395.1	Code: L; COG: COG2963
YP_402396.1	Code: L; COG: COG2963
YP_402397.1	Code: L; COG: COG2801
YP_402399.1	Code: R; COG: COG1783
YP_402400.1	Code: L; COG: COG2801
YP_402401.1	Code: L; COG: COG2963
YP_402402.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402403.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402407.1	Code: L; COG: COG3677
YP_402408.1	Code: L; COG: COG1662
YP_402409.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_402411.1	permease; Code: E; COG: COG1177
YP_402412.1	permease; Code: E; COG: COG1176
YP_402413.1	part of the PotFGHI ATP-dependent putrescine transporter
YP_402414.1	permease; Code: E; COG: COG0687
YP_402416.1	responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6
YP_402417.1	NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds
YP_402418.1	YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function
YP_402419.1	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_402421.1	Code: R; COG: COG2985
YP_402422.1	Code: E; COG: COG1045
YP_402423.1	Code: S; COG: COG3226
YP_402424.1	Code: GEPR; COG: COG0477
YP_402426.1	Code: L; COG: COG1662
YP_402427.1	Code: L; COG: COG3677
YP_402428.1	Code: EP; COG: COG1173
YP_402429.1	Code: EP; COG: COG0601
YP_402430.1	Code: E; COG: COG0747
YP_402431.1	with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains
YP_402432.1	Code: E; COG: COG1446
YP_402433.1	is involved in the formation of active molybdenum cofactor and the chelation of molybdenum
YP_402434.1	''ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase''
YP_402435.2	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_402436.1	Code: O; COG: COG1180
YP_402437.1	Code: C; COG: COG1882
YP_402438.1	Code: R; COG: COG0561
YP_402439.1	Code: L; COG: COG1662
YP_402440.1	Code: K; COG: COG1396
YP_402442.1	Code: L; COG: COG2801
YP_402443.1	Code: L; COG: COG2963
YP_402449.1	Code: R; COG: COG0488
YP_402450.1	Code: S; COG: COG1376
YP_402452.1	Transcriptional regulator that represses the manganese transporter MntH when manganese is present
YP_402453.1	Code: R; COG: COG2194
YP_402454.1	OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains
YP_402455.1	for starvation conditions; binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage
YP_402456.1	Code: L; COG: COG3677
YP_402457.1	permease; similar to periplasmic-binding component of ABC transporters
YP_402458.1	similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine
YP_402459.1	similar to ATP-binding component of ABC transporters
YP_402460.1	Code: L; COG: COG1662
YP_402461.1	Code: R; COG: COG3129
YP_402464.1	Code: L; COG: COG3385
YP_402465.1	''Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein''
YP_402466.2	Code: S; COG: COG3128
YP_402467.1	Code: T; COG: COG1734
YP_402469.1	Code: C; COG: COG2055
YP_402470.1	Code: E; COG: COG0547
YP_402471.1	helicase involved in DNA repair and perhaps also replication
YP_402472.1	Code: L; COG: COG1662
YP_402476.1	Code: L; COG: COG1662
YP_402477.1	this helicase is not essential cell growth
YP_402478.1	Code: K; COG: COG1309
YP_402479.1	Code: M; COG: COG0845
YP_402480.1	Code: V; COG: COG1131
YP_402481.1	Code: V; COG: COG0842
YP_402482.1	Code: V; COG: COG0842
YP_402484.1	Code: R; COG: COG3568
YP_402485.1	Code: I; COG: COG1502
YP_402486.1	Code: S; COG: COG0392
YP_402487.1	Code: L; COG: COG3677
YP_402488.1	Code: R; COG: COG0670
YP_402489.2	Code: L; COG: COG1662
YP_402490.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402491.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402492.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_402493.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_402494.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_402495.1	Code: H; COG: COG0521
YP_402496.1	''together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z''
YP_402497.1	Code: S; COG: COG0391
YP_402498.1	DNA repair; ''The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion''
YP_402499.1	''DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium''
YP_402500.1	reaction prior to pimeloyl CoA; ''methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth''
YP_402501.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_402502.1	possible sulfur insertion; Code: H; COG: COG0502
YP_402503.1	''catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate''
YP_402504.1	YbhB; similar to rat and human kinase inhibitory proteins
YP_402505.1	Code: S; COG: COG4886
YP_402506.1	Code: L; COG: COG2963
YP_402507.1	Code: L; COG: COG2801
YP_402509.1	Code: O; COG: COG0625
YP_402510.1	Code: L; COG: COG1662
YP_402512.1	penicillin-binding protein 6; ''penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''
YP_402513.1	Code: KG; COG: COG1349
YP_402514.1	Code: I; COG: COG0671
YP_402515.1	Code: L; COG: COG2963
YP_402516.1	Code: L; COG: COG2801
YP_402517.1	Code: L; COG: COG2801
YP_402519.1	Code: L; COG: COG2963
YP_402520.1	Code: L; COG: COG2801
YP_402521.1	Code: R; COG: COG2373
YP_402522.1	Code: S; COG: COG5445
YP_402525.2	probable histidine kinase acting on RcsB; Code: T; COG: COG0642
YP_402526.1	sensor, RcsC; two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF
YP_402527.1	Code: T; COG: COG0642
YP_402528.1	Code: L; COG: COG1662
YP_402530.1	Ib;c; allows for ions and hydrophilic solutes to cross the outer membrane
YP_402531.1	catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway
YP_402532.1	transcription activator/repressor; Code: F; COG: COG2169
YP_402533.1	Code: L; COG: COG3145
YP_402534.1	efflux pump for the antibacterial peptide microcin J25
YP_402535.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_402536.1	Code: L; COG: COG2801
YP_402537.1	Code: L; COG: COG2963
YP_402538.1	electron transfer; Predicted role in electron transfer to the periplasmic nitrate reductase NapA
YP_402539.1	Code: P; COG: COG3062
YP_402540.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_402541.1	electron transfer; part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_402542.1	electron transfer; part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_402543.2	small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA
YP_402544.1	with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone
YP_402545.1	ATP-binding protein; required for proper cytochrome c maturation
YP_402546.1	cytochrome c-type biogenesis protein; Code: O; COG: COG2386
YP_402547.1	Code: O; COG: COG0755
YP_402548.1	Code: U; COG: COG3114
YP_402549.1	possible subunit of a heme lyase; CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_402550.1	Code: O; COG: COG1138
YP_402551.1	possibly involved in biogenesis of cytochrome c; Code: OC; COG: COG0526
YP_402552.1	Code: O; COG: COG4235
YP_402553.1	sensor NarQ; nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes
YP_402554.1	Code: L; COG: COG1662
YP_402556.1	Code: L; COG: COG3677
YP_402557.1	Code: MU; COG: COG3468
YP_402558.1	Code: R; COG: COG3083
YP_402559.1	Code: S; COG: COG3082
YP_402560.1	Code: R; COG: COG3081
YP_402561.1	''the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response''
YP_402562.1	Code: KL; COG: COG1061
YP_402563.1	catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA
YP_402564.1	transmembrane protein; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance
YP_402566.1	Code: R; COG: COG4172
YP_402567.1	Code: R; COG: COG4239
YP_402568.1	Code: R; COG: COG4174
YP_402569.2	Code: E; COG: COG4166
YP_402570.1	Code: T; COG: COG2200
YP_402571.1	''by similarity, Spr seems to have peptidase activity; involved in thermoresistance''
YP_402572.1	Code: I; COG: COG0671
YP_402573.1	Code: R; COG: COG0523
YP_402575.2	''Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein''
YP_402576.1	Code: GEPR; COG: COG0477
YP_402581.1	Code: NU; COG: COG3539
YP_402582.1	Code: NU; COG: COG3539
YP_402583.1	Code: NU; COG: COG3539
YP_402584.1	Code: NU; COG: COG3121
YP_402585.1	''catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors''
YP_402587.1	Code: R; COG: COG3217
YP_402588.1	catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_402589.1	Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
YP_402590.1	Code: S; COG: COG2995
YP_402591.1	Code: R; COG: COG3008
YP_402592.1	Code: S; COG: COG3009
YP_402593.1	Code: J; COG: COG3130
YP_402594.1	trans-2-decenoyl-ACP isomerase; ''catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP''
YP_402595.1	Code: S; COG: COG3120
YP_402596.1	II*;G;d; ''OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d''
YP_402597.1	Code: L; COG: COG2963
YP_402598.1	Code: L; COG: COG2801
YP_402599.1	Code: K; COG: COG3070
YP_402600.1	Code: S; COG: COG1289
YP_402601.1	Code: S; COG: COG3304
YP_402602.1	catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand
YP_402603.2	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_402604.1	Code: S; COG: COG3110
YP_402605.1	Code: R; COG: COG1832
YP_402606.1	Code: S; COG: COG3785
YP_402607.1	Code: R; COG: COG1092
YP_402608.1	Code: C; COG: COG1254
YP_402609.2	transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs
YP_402610.1	Code: R; COG: COG0670
YP_402611.1	Code: C; COG: COG1740
YP_402613.1	Code: C; COG: COG1969
YP_402614.1	HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1)
YP_402615.1	involved in processing hydrogenases HyaA and HyaB
YP_402616.1	Code: C; COG: COG1271
YP_402617.1	Code: C; COG: COG1294
YP_402618.1	Code: S; COG: COG4890
YP_402619.1	pH 2.5 acid phosphatase; periplasmic
YP_402620.1	Code: M; COG: COG3206
YP_402621.2	''Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk''
YP_402622.1	Code: M; COG: COG1596
YP_402627.1	Code: K; COG: COG1278
YP_402628.1	Code: L; COG: COG1662
YP_402629.1	Code: C; COG: COG0348
YP_402630.1	part of regulation of tor operon, periplasmic; periplasmic sensory protein associated with the TorRS two-component regulatory system
YP_402631.1	sensor TorS; response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes
YP_402632.1	''TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor''
YP_402633.1	with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA
YP_402634.1	functions closely related to DnaJ; ''functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock''
YP_402636.1	Code: L; COG: COG1662
YP_402640.1	affects association of trp repressor and operator; stationary phase that binds TrpR repressor
YP_402641.1	Code: F; COG: COG2233
YP_402642.1	Code: R; COG: COG1853
YP_402643.1	Code: C; COG: COG0778
YP_402644.1	Code: R; COG: COG0596
YP_402645.1	Code: J; COG: COG0251
YP_402646.1	Code: C; COG: COG2141
YP_402647.1	Code: K; COG: COG1309
YP_402648.1	Code: ER; COG: COG0591
YP_402651.1	Code: L; COG: COG3677
YP_402652.1	Code: L; COG: COG1662
YP_402654.1	2nd curli operon; chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_402655.1	2nd curli operon; nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_402656.1	2nd curli operon; Code: M; COG: COG1462
YP_402657.1	Code: L; COG: COG1662
YP_402659.1	Code: R; COG: COG3381
YP_402660.1	Code: ER; COG: COG1387
YP_402661.1	Code: HE; COG: COG0111
YP_402669.1	Code: L; COG: COG2003
YP_402674.1	Code: L; COG: COG2801
YP_402675.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402676.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402677.1	Code: L; COG: COG1662
YP_402678.1	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_402679.1	Code: R; COG: COG2819
YP_402680.1	Code: P; COG: COG2382
YP_402681.1	Code: V; COG: COG1132
YP_402682.1	Code: GC; COG: COG1819
YP_402686.1	Code: L; COG: COG2963
YP_402687.1	Code: L; COG: COG1662
YP_402689.1	Code: R; COG: COG3443
YP_402690.1	in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme
YP_402691.1	in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ
YP_402692.1	Code: L; COG: COG1662
YP_402694.1	Code: R; COG: COG2351
YP_402695.2	induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced
YP_402696.1	Code: L; COG: COG1662
YP_402701.1	Code: L; COG: COG0270
YP_402702.1	Code: L; COG: COG3727
YP_402703.1	Code: GER; COG: COG0697
YP_402704.1	Code: S; COG: COG2354
YP_402705.1	Code: S; COG: COG5475
YP_402706.1	Code: T; COG: COG2199
YP_402707.1	catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
YP_402710.1	Code: L; COG: COG1662
YP_402711.1	Code: L; COG: COG1662
YP_402712.1	Code: L; COG: COG3677
YP_402713.1	Code: L; COG: COG1662
YP_402716.2	Code: QR; COG: COG0500
YP_402717.1	Code: L; COG: COG1662
YP_402719.1	Code: L; COG: COG2801
YP_402720.1	Code: L; COG: COG2963
YP_402724.1	Code: L; COG: COG2963
YP_402725.1	Code: L; COG: COG2801
YP_402726.1	Code: L; COG: COG1662
YP_402727.1	Code: S; COG: COG3228
YP_402732.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402733.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402735.1	Code: L; COG: COG1662
YP_402737.1	Code: L; COG: COG1662
YP_402738.1	Code: S; COG: COG2135
YP_402739.1	Code: O; COG: COG0425
YP_402740.1	Code: R; COG: COG2391
YP_402742.1	''converts 1,4-alpha-D-glucans to maltodextrin''
YP_402743.1	flagellar biosynthesis; RflA activity; flagellin specific chaperone
YP_402744.1	flagellar biosynthesis; enables filament assembly; involved in flagellin assembly
YP_402745.1	Code: L; COG: COG1662
YP_402746.1	Code: L; COG: COG3677
YP_402747.1	flagellar biosynthesis; regulation of flagellar operons; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes
YP_402748.1	''expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence''
YP_402749.1	Code: ET; COG: COG0834
YP_402750.2	catalyzes the formation of pyruvate from D-cysteine
YP_402751.1	formerly yecC; Code: E; COG: COG0765
YP_402752.1	Code: E; COG: COG1126
YP_402753.1	Code: L; COG: COG1662
YP_402755.1	in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system
YP_402756.2	repair of UV damage to DNA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_402757.1	Code: I; COG: COG0558
YP_402758.1	Code: R; COG: COG3318
YP_402759.1	Code: E; COG: COG0814
YP_402761.1	iron storage protein; cytoplasmic iron storage protein
YP_402763.1	Code: L; COG: COG1662
YP_402764.1	Code: P; COG: COG1528
YP_402766.1	Code: L; COG: COG1662
YP_402768.1	Code: G; COG: COG1879
YP_402769.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_402770.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_402771.1	Code: L; COG: COG2963
YP_402775.1	Code: R; COG: COG2372
YP_402777.1	Code: R; COG: COG0388
YP_402778.1	3'-5' exonuclease activity on single or double-strand DNA
YP_402779.1	PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues
YP_402780.1	Code: S; COG: COG2979
YP_402781.1	secreted protein; unknown function
YP_402782.1	Code: S; COG: COG3141
YP_402783.1	''non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis''
YP_402784.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_402785.1	catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate
YP_402786.1	''catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate''
YP_402789.1	glucose stimulated; catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_402790.1	heat shock protein; ''Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA''
YP_402791.2	Code: M; COG: COG0739
YP_402792.2	involved in transport of zinc(II) with ZnuA and C
YP_402793.1	involved in transport of zinc(II) with ZnuA and C
YP_402794.1	involved in transport of zinc(II) with ZnuA and C
YP_402795.1	branch migration; repair; promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_402796.1	branch migration; repair; plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_402798.1	resolution of structures; repair; endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_402799.1	Code: S; COG: COG0217
YP_402800.1	converts dATP to dAMP and pyrophosphate
YP_402801.1	''catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes''
YP_402803.1	Code: L; COG: COG3547
YP_402804.1	Code: L; COG: COG3677
YP_402806.1	Code: L; COG: COG2963
YP_402809.1	Code: L; COG: COG1662
YP_402810.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402811.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402812.1	Code: L; COG: COG3677
YP_402813.1	Code: L; COG: COG1662
YP_402816.2	Code: R; COG: COG3788
YP_402817.1	Code: QR; COG: COG0500
YP_402818.1	Code: QR; COG: COG0500
YP_402819.1	Code: C; COG: COG0243
YP_402822.1	Code: L; COG: COG1662
YP_402823.1	Code: L; COG: COG1662
YP_402825.1	Code: P; COG: COG3142
YP_402826.1	Code: S; COG: COG3102
YP_402827.1	''catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase''
YP_402828.1	Code: L; COG: COG3677
YP_402829.1	Code: L; COG: COG1662
YP_402831.1	Code: L; COG: COG1662
YP_402832.1	Code: L; COG: COG2963
YP_402833.1	Code: L; COG: COG2801
YP_402834.1	no effect on switching; With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_402835.1	transcription initiation factor; With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems
YP_402836.1	transcriptional initiation factor; with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems
YP_402837.1	''ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress''
YP_402838.1	Code: G; COG: COG0380
YP_402839.1	Code: L; COG: COG2801
YP_402840.1	Code: L; COG: COG2963
YP_402841.1	Code: L; COG: COG2801
YP_402842.1	Code: L; COG: COG2963
YP_402843.1	Code: L; COG: COG3677
YP_402844.1	Code: L; COG: COG1662
YP_402845.1	Code: L; COG: COG1662
YP_402847.1	Code: L; COG: COG1662
YP_402848.1	Code: MU; COG: COG3468
YP_402849.1	reverses MinC inhibition of ftsZ ring formation; works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_402850.1	cell division inhibitor, a membrane ATPase, activates minC; ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums
YP_402851.1	cell division inhibitor, inhibits ftsZ ring formation; blocks the formation of polar Z-ring septums
YP_402852.1	Code: L; COG: COG1662
YP_402855.1	Code: S; COG: COG3100
YP_402856.1	Code: Q; COG: COG0179
YP_402857.2	Code: S; COG: COG2983
YP_402858.1	Code: L; COG: COG3677
YP_402859.1	Code: L; COG: COG1662
YP_402860.1	Code: L; COG: COG1662
YP_402862.1	Code: L; COG: COG1662
YP_402863.1	SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC; binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_402864.1	binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_402865.1	reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella; disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein
YP_402866.1	involved in regulation of intracellular pH under alkaline conditions
YP_402867.1	Multifunctional regulator of fatty acid metabolism
YP_402868.1	Code: S; COG: COG2719
YP_402869.1	catalyzes the oxidative deamination of D-amino acids
YP_402872.2	the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
YP_402873.1	catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine
YP_402874.1	Code: M; COG: COG0741
YP_402875.1	Code: M; COG: COG5581
YP_402876.1	Code: S; COG: COG2261
YP_402877.1	probably tonB dependent; Code: P; COG: COG1629
YP_402878.1	involved in molybdenum transport
YP_402880.1	Code: L; COG: COG1662
YP_402881.1	Code: QR; COG: COG0500
YP_402882.1	Code: PH; COG: COG1120
YP_402883.1	Code: P; COG: COG0609
YP_402887.1	periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell
YP_402889.1	Code: G; COG: COG2376
YP_402891.1	Code: L; COG: COG1662
YP_402892.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_402893.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_402894.1	''YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function''
YP_402895.1	role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport
YP_402896.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_402897.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_402898.1	Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_402899.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_402900.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_402901.1	HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB
YP_402902.1	Code: S; COG: COG3094
YP_402903.1	Code: S; COG: COG2912
YP_402904.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_402906.1	Code: P; COG: COG0387
YP_402907.1	Code: L; COG: COG3677
YP_402909.1	in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions
YP_402910.1	Code: P; COG: COG3703
YP_402911.1	Code: P; COG: COG1553
YP_402913.1	Code: L; COG: COG1662
YP_402914.1	pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase
YP_402915.1	histidine protein kinase acts on NarL regulator; Code: T; COG: COG3850
YP_402917.1	Code: P; COG: COG2223
YP_402918.1	Code: C; COG: COG5013
YP_402919.1	Code: C; COG: COG1140
YP_402920.1	Code: C; COG: COG2180
YP_402921.1	Code: C; COG: COG2181
YP_402922.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_402923.1	Code: S; COG: COG3012
YP_402925.1	Code: T; COG: COG0784
YP_402926.1	''together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose''
YP_402927.1	HU, BH2, HD, NS; pleiotropic regulator; Code: R; COG: COG2916
YP_402928.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_402929.1	Code: L; COG: COG1662
YP_402930.1	Code: L; COG: COG3385
YP_402931.1	Code: L; COG: COG3677
YP_402933.1	Code: C; COG: COG1454
YP_402934.1	Code: L; COG: COG1662
YP_402935.1	Code: L; COG: COG3677
YP_402936.1	Code: L; COG: COG1662
YP_402937.1	Code: L; COG: COG1662
YP_402939.1	oligopeptide transport; periplasmic binding protein; Code: E; COG: COG4166
YP_402940.1	Code: EP; COG: COG0601
YP_402941.1	Code: EP; COG: COG1173
YP_402942.1	Code: EP; COG: COG0444
YP_402943.1	Code: E; COG: COG4608
YP_402944.2	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_402945.1	a major membrane phospholipid; novobiocin sensitivity; catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol)
YP_402946.1	Code: P; COG: COG1226
YP_402947.2	''unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity''
YP_402948.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_402949.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_402950.1	Code: L; COG: COG1961
YP_402951.1	Code: L; COG: COG2963
YP_402954.1	energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins; ''membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins''
YP_402955.1	YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins
YP_402956.1	Involved in cell division; probably involved in intracellular septation
YP_402958.1	receptor for colicin S4
YP_402959.1	Code: S; COG: COG3685
YP_402961.1	Code: L; COG: COG3677
YP_402962.1	Code: L; COG: COG1662
YP_402964.1	Code: L; COG: COG2963
YP_402966.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_402967.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_402968.1	monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_402969.1	glutamine amidotransferase and phosphoribosylanthranilate transferase; bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis
YP_402970.1	''with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine''
YP_402972.1	Code: R; COG: COG0613
YP_402973.1	Code: J; COG: COG0009
YP_402974.1	Code: L; COG: COG3677
YP_402975.1	Code: L; COG: COG1662
YP_402977.1	catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA
YP_402978.1	''catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide''
YP_402979.1	Code: IQR; COG: COG1028
YP_402980.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_402982.1	''catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity''
YP_402983.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_402984.1	Code: L; COG: COG1662
YP_402985.1	Code: L; COG: COG3677
YP_402989.1	Code: L; COG: COG2963
YP_402990.1	''catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate''
YP_402991.1	Code: I; COG: COG0671
YP_402992.1	Code: S; COG: COG3771
YP_402993.1	Code: G; COG: COG2956
YP_402994.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_402995.1	involved in start site selection during the initiation of translation
YP_402996.1	Code: L; COG: COG1662
YP_402997.1	Code: L; COG: COG3677
YP_402998.1	Code: KG; COG: COG1349
YP_403000.1	Code: L; COG: COG3677
YP_403001.1	Code: L; COG: COG1662
YP_403002.1	mRNA degradation; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YP_403004.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_403005.1	Code: L; COG: COG1662
YP_403007.1	Code: L; COG: COG1662
YP_403008.1	Code: V; COG: COG0841
YP_403011.1	Code: GEPR; COG: COG0477
YP_403012.1	Code: L; COG: COG3547
YP_403013.1	Code: V; COG: COG4167
YP_403014.1	Code: V; COG: COG4170
YP_403015.1	Code: V; COG: COG4171
YP_403016.1	Code: L; COG: COG0582
YP_403017.1	Code: L; COG: COG3677
YP_403022.1	Code: L; COG: COG2963
YP_403027.1	Code: L; COG: COG2801
YP_403030.1	Code: R; COG: COG3772
YP_403031.1	Code: L; COG: COG2801
YP_403032.1	Code: L; COG: COG3677
YP_403033.1	Code: L; COG: COG1662
YP_403034.1	Code: R; COG: COG3106
YP_403035.1	Code: S; COG: COG3768
YP_403036.1	transcriptional regulation of aroF, aroG, tyrA and aromatic amino acid transport; regulates genes involved in the biosynthesis and transport of aromatic amino acids
YP_403037.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_403038.1	Code: MR; COG: COG4948
YP_403039.1	Code: E; COG: COG2866
YP_403040.1	Code: L; COG: COG1662
YP_403042.1	Code: L; COG: COG1662
YP_403043.1	Code: K; COG: COG0583
YP_403044.1	Code: E; COG: COG4166
YP_403045.1	Code: M; COG: COG0668
YP_403046.1	Code: L; COG: COG1662
YP_403047.1	Code: L; COG: COG3677
YP_403048.1	with UspC and UspD is involved in resistance to UV irradiation
YP_403049.1	Code: L; COG: COG1662
YP_403050.1	transcriptional regulation of aerobic, anaerobic respiration, osmotic balance; Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_403051.1	Code: L; COG: COG0350
YP_403053.1	Code: L; COG: COG1662
YP_403054.1	Code: S; COG: COG2840
YP_403055.1	Code: T; COG: COG2199
YP_403056.1	Code: L; COG: COG2963
YP_403057.1	Code: L; COG: COG2801
YP_403058.1	Code: T; COG: COG2202
YP_403059.1	Code: P; COG: COG0598
YP_403060.1	TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs
YP_403064.1	Code: L; COG: COG3677
YP_403065.1	Code: L; COG: COG1662
YP_403069.1	Code: L; COG: COG4570
YP_403071.1	Code: L; COG: COG3677
YP_403072.1	Code: L; COG: COG1662
YP_403074.1	Code: L; COG: COG1662
YP_403076.1	Code: L; COG: COG2963
YP_403078.1	Code: L; COG: COG1662
YP_403081.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_403082.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_403084.1	Code: L; COG: COG2963
YP_403086.1	Code: P; COG: COG1108
YP_403087.1	Code: P; COG: COG1108
YP_403088.1	Code: P; COG: COG1121
YP_403089.1	Code: P; COG: COG0803
YP_403090.1	Code: T; COG: COG0589
YP_403091.1	Code: L; COG: COG2801
YP_403092.1	Code: C; COG: COG0674
YP_403093.1	Code: R; COG: COG3042
YP_403094.1	Code: CHR; COG: COG1052
YP_403098.1	Code: L; COG: COG1662
YP_403099.1	Code: L; COG: COG3677
YP_403100.1	Code: L; COG: COG1662
YP_403102.1	Code: I; COG: COG0558
YP_403103.1	Code: L; COG: COG1662
YP_403104.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_403105.1	YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate
YP_403108.1	Code: L; COG: COG1662
YP_403109.1	Code: L; COG: COG3677
YP_403111.1	Code: L; COG: COG2963
YP_403112.1	Code: L; COG: COG3677
YP_403113.1	Code: GEPR; COG: COG0477
YP_403114.1	Code: L; COG: COG1662
YP_403115.1	Code: M; COG: COG3713
YP_403116.1	Code: R; COG: COG0656
YP_403117.1	Code: G; COG: COG0676
YP_403118.1	Code: G; COG: COG0057
YP_403119.1	this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress
YP_403120.1	Code: S; COG: COG3139
YP_403121.1	Code: ER; COG: COG1063
YP_403122.1	Code: GEPR; COG: COG0477
YP_403123.1	Code: ER; COG: COG1063
YP_403124.1	Code: L; COG: COG3677
YP_403125.1	Code: G; COG: COG0524
YP_403128.1	Code: KG; COG: COG1349
YP_403130.1	Code: L; COG: COG3677
YP_403131.1	Code: L; COG: COG1662
YP_403132.1	Code: L; COG: COG1662
YP_403134.2	catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide
YP_403135.1	converts asparagine to aspartate and ammonia
YP_403136.1	signal peptide peptidase; SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane
YP_403137.1	Code: C; COG: COG0778
YP_403138.1	H(2)Se added to acrylyl-tRNA; catalyzes the formation of selenophosphate from selenide and ATP
YP_403139.1	decatenates replicating daughter chromosomes
YP_403141.1	Code: L; COG: COG1662
YP_403143.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_403145.1	Code: LR; COG: COG0494
YP_403147.1	Code: R; COG: COG4136
YP_403151.1	Code: S; COG: COG2128
YP_403152.1	Code: S; COG: COG0398
YP_403154.1	Code: S; COG: COG0398
YP_403155.1	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_403156.1	Code: L; COG: COG3677
YP_403157.1	Code: E; COG: COG3138
YP_403158.1	Code: C; COG: COG1012
YP_403159.2	''catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation''
YP_403161.1	periplasmic protein related to spheroblast formation; periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP
YP_403166.1	3' incision activity; acts with UvrC
YP_403167.1	prefers NH3 over glutamine; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_403168.1	osmotically-inducible lipoprotein E; activator of ntr-like gene protein
YP_403169.1	Code: L; COG: COG1662
YP_403171.1	Code: L; COG: COG3677
YP_403172.1	Code: L; COG: COG1662
YP_403173.1	Code: R; COG: COG3136
YP_403174.1	Code: IQR; COG: COG1028
YP_403175.1	Code: E; COG: COG0531
YP_403177.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_403178.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_403179.1	transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes
YP_403180.1	''with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS''
YP_403181.1	''with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS''
YP_403182.1	Code: E; COG: COG3591
YP_403183.2	required for growth and survival under moderately acid conditions
YP_403187.1	Code: L; COG: COG1662
YP_403188.1	Code: K; COG: COG0583
YP_403189.1	Code: KG; COG: COG1940
YP_403190.2	''DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium''
YP_403191.1	Code: P; COG: COG0038
YP_403192.1	Code: R; COG: COG3302
YP_403193.1	Code: C; COG: COG0437
YP_403198.1	Code: L; COG: COG1662
YP_403200.1	Code: S; COG: COG1742
YP_403201.1	Code: L; COG: COG1662
YP_403203.1	Code: GEPR; COG: COG0477
YP_403205.1	Code: K; COG: COG1802
YP_403206.1	''NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine''
YP_403207.1	Code: E; COG: COG0339
YP_403208.1	Code: R; COG: COG1546
YP_403209.1	Code: S; COG: COG3111
YP_403210.1	Code: T; COG: COG2199
YP_403211.1	Code: L; COG: COG3677
YP_403212.1	Code: L; COG: COG1662
YP_403213.1	YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters
YP_403214.2	Code: GER; COG: COG0697
YP_403215.2	multiple antibiotic resistance; transcriptional activator of defense systems; ''transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF''
YP_403216.2	multiple antibiotic resistance protein; repressor of mar operon; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
YP_403217.1	''protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function''
YP_403218.1	Code: G; COG: COG2814
YP_403220.1	Code: L; COG: COG1662
YP_403222.1	Code: GER; COG: COG0697
YP_403223.1	Code: C; COG: COG0437
YP_403224.1	''nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase''
YP_403225.1	Code: R; COG: COG3093
YP_403226.2	similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs
YP_403227.1	Code: O; COG: COG1764
YP_403228.1	Code: EP; COG: COG1124
YP_403229.1	Code: S; COG: COG1649
YP_403230.1	Code: E; COG: COG0531
YP_403231.1	Code: E; COG: COG0076
YP_403236.1	Code: L; COG: COG3677
YP_403239.1	Code: G; COG: COG1830
YP_403240.1	Code: S; COG: COG1359
YP_403241.1	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate
YP_403244.1	Code: T; COG: COG2199
YP_403246.1	catalyzes the formation of glutamate from glutamine
YP_403247.1	in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase
YP_403248.1	Code: K; COG: COG0583
YP_403250.1	Code: L; COG: COG1662
YP_403253.1	Code: E; COG: COG4166
YP_403254.1	Code: V; COG: COG4168
YP_403259.1	Code: L; COG: COG2963
YP_403260.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_403261.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_403264.1	Code: C; COG: COG1140
YP_403265.1	Code: C; COG: COG2180
YP_403266.1	Code: C; COG: COG2181
YP_403267.1	Code: R; COG: COG0384
YP_403270.1	in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase
YP_403272.1	regulates the cellular response to acid resistance
YP_403274.1	Code: L; COG: COG1662
YP_403279.1	Code: L; COG: COG1662
YP_403284.1	Code: L; COG: COG2963
YP_403286.1	Code: Q; COG: COG2050
YP_403287.1	Code: C; COG: COG0277
YP_403288.1	''YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function''
YP_403290.1	Code: L; COG: COG2963
YP_403292.1	Code: L; COG: COG1662
YP_403296.1	Code: T; COG: COG2199
YP_403297.1	Code: S; COG: COG2606
YP_403299.1	Code: S; COG: COG2707
YP_403300.1	Code: K; COG: COG2207
YP_403301.1	Code: P; COG: COG2807
YP_403302.1	Code: S; COG: COG3189
YP_403303.1	Code: R; COG: COG3042
YP_403304.1	Code: T; COG: COG2203
YP_403305.2	Code: L; COG: COG1662
YP_403307.1	Code: S; COG: COG2261
YP_403309.1	Code: P; COG: COG3615
YP_403310.1	Code: E; COG: COG1280
YP_403311.1	Code: L; COG: COG1662
YP_403312.1	Code: K; COG: COG0583
YP_403313.1	Code: CE; COG: COG0473
YP_403316.1	Code: L; COG: COG1662
YP_403317.1	Code: PR; COG: COG4638
YP_403318.1	Code: C; COG: COG1018
YP_403319.1	processes tRNA precursor; Code: J; COG: COG0349
YP_403320.1	Activates fatty acids by binding to coenzyme A
YP_403321.1	Code: M; COG: COG3065
YP_403322.1	Code: O; COG: COG1214
YP_403323.1	Code: KL; COG: COG1199
YP_403324.1	Code: J; COG: COG0251
YP_403325.1	Code: L; COG: COG3677
YP_403326.1	Code: L; COG: COG1662
YP_403328.1	Code: S; COG: COG3140
YP_403329.1	Code: EH; COG: COG0147
YP_403330.1	Code: LR; COG: COG0494
YP_403331.1	Code: E; COG: COG1760
YP_403332.1	Code: L; COG: COG3677
YP_403333.1	Code: L; COG: COG1662
YP_403335.1	Code: R; COG: COG2130
YP_403336.1	Code: M; COG: COG1247
YP_403337.1	Code: S; COG: COG3238
YP_403338.1	Code: L; COG: COG1662
YP_403341.1	catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation
YP_403342.1	Code: E; COG: COG3842
YP_403343.1	Code: E; COG: COG0687
YP_403344.1	multi modular; also ATP-binding component of a transport system; Code: KE; COG: COG1167
YP_403345.1	Code: S; COG: COG1598
YP_403347.1	Code: L; COG: COG1662
YP_403349.1	Code: O; COG: COG0826
YP_403350.1	Code: K; COG: COG1396
YP_403352.1	Code: L; COG: COG1662
YP_403353.1	Code: L; COG: COG3677
YP_403355.1	with TehA confers resistance to tellurite
YP_403356.1	Code: P; COG: COG1275
YP_403359.1	acetylation of N-terminal serine of 30S ribosomal subunit protein L7; Code: J; COG: COG1670
YP_403360.1	Code: S; COG: COG2841
YP_403361.1	Code: L; COG: COG3677
YP_403362.1	Code: L; COG: COG1662
YP_403364.1	involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans
YP_403365.1	Code: S; COG: COG5383
YP_403366.1	Code: K; COG: COG0583
YP_403367.1	Code: L; COG: COG1662
YP_403368.1	ribose sensor receptor; Code: NT; COG: COG0840
YP_403369.1	Code: L; COG: COG1662
YP_403372.2	B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm
YP_403374.1	Code: L; COG: COG2963
YP_403377.1	Code: L; COG: COG3677
YP_403378.1	Code: L; COG: COG1662
YP_403380.1	''involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain''
YP_403381.1	FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds
YP_403382.1	Code: I; COG: COG0671
YP_403384.1	Code: L; COG: COG1662
YP_403385.1	Code: QR; COG: COG0500
YP_403388.2	may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_403389.1	Code: L; COG: COG2801
YP_403390.1	Code: L; COG: COG2963
YP_403391.1	Code: K; COG: COG2207
YP_403393.1	Code: L; COG: COG2963
YP_403394.1	flavoprotein; probably electron transport; Code: C; COG: COG0644
YP_403395.1	Code: C; COG: COG2440
YP_403396.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_403397.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_403399.1	Code: S; COG: COG1806
YP_403400.1	DAHP synthetase, tryptophan repressible; tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate
YP_403401.1	Code: P; COG: COG4256
YP_403404.1	Code: T; COG: COG2200
YP_403405.1	Code: M; COG: COG0791
YP_403406.1	ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell
YP_403407.1	similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane
YP_403408.1	with BtuD and BtuF transports vitamin B12 into the cell
YP_403409.1	IHF; site-specific recombination; ''This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control''
YP_403410.1	''catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily''
YP_403411.1	''catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily''
YP_403413.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_403414.1	Code: J; COG: COG0291
YP_403415.2	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_403416.1	''catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''
YP_403417.1	Code: L; COG: COG1662
YP_403418.1	suppressor of pfkA; Code: G; COG: COG1105
YP_403420.1	Code: G; COG: COG3001
YP_403422.1	''YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate''
YP_403423.2	Code: R; COG: COG1988
YP_403424.1	Code: L; COG: COG1662
YP_403425.1	Code: L; COG: COG3677
YP_403426.1	RstB sensor; response regulator in two-component regulatory system with RstB
YP_403427.1	RstA regulator; Code: T; COG: COG0642
YP_403428.1	inhibition of replication at Ter sites; binds to DNA replication terminator sequences to prevent passage of replication forks
YP_403429.1	fumarate hydratase Class II; isozyme; class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_403430.1	fumarate hydratase Class I; aerobic isozyme; Code: C; COG: COG1951
YP_403431.1	Code: G; COG: COG1482
YP_403432.1	Code: S; COG: COG5339
YP_403433.1	Code: L; COG: COG1662
YP_403437.1	Code: K; COG: COG1309
YP_403438.1	dehydroxylation of bile acids; Acts on the hydroxyl group at position 7 of the steroid frame
YP_403441.1	regulates malXY which are involved in maltose-glucose transport
YP_403442.1	Code: G; COG: COG1263
YP_403443.1	Code: L; COG: COG1662
YP_403445.1	enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase; Code: E; COG: COG1168
YP_403446.1	catalyzes the formation of inosine from adenosine
YP_403447.2	Code: R; COG: COG0673
YP_403448.1	''YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes''
YP_403450.1	Code: C; COG: COG4657
YP_403451.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_403452.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_403453.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_403454.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_403455.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_403456.1	specific for apurinic and/or apyrimidinic sites; ''DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines''
YP_403457.1	mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation
YP_403458.1	Code: O; COG: COG0625
YP_403459.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_403460.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_403461.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_403462.2	Code: R; COG: COG3895
YP_403463.1	''catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling''
YP_403464.1	Code: M; COG: COG3133
YP_403465.2	Transcription regulator that can both activate or repress expression
YP_403467.1	Code: V; COG: COG1566
YP_403470.1	SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water
YP_403471.1	Code: R; COG: COG4989
YP_403472.1	Code: R; COG: COG3313
YP_403473.1	Code: K; COG: COG1309
YP_403474.1	Code: L; COG: COG1662
YP_403477.1	Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione
YP_403478.1	Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_403479.1	Code: O; COG: COG0278
YP_403480.1	Code: M; COG: COG0791
YP_403481.1	SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals
YP_403482.1	Code: G; COG: COG2814
YP_403483.1	transcriptional repressor for pur regulon, glyA, glnB, prsA, speA; ''binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers''
YP_403484.1	Code: K; COG: COG0583
YP_403485.1	uncharacterized member of the major facilitator superfamily (MFS)
YP_403486.1	catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
YP_403487.1	''catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine''
YP_403488.1	Code: L; COG: COG1662
YP_403489.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_403490.1	Code: MU; COG: COG3468
YP_403492.1	Code: L; COG: COG2963
YP_403495.1	Code: C; COG: COG4117
YP_403496.1	Code: C; COG: COG0437
YP_403498.1	Code: L; COG: COG2963
YP_403502.1	formerly F; catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_403503.1	Code: L; COG: COG3677
YP_403505.1	Code: M; COG: COG4238
YP_403506.1	Code: S; COG: COG1376
YP_403507.1	Acts with SufS to catalyze the formation of L-alanine from L-cysteine
YP_403509.1	with SufBC activates cysteine desulfurase SufS
YP_403510.1	part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE
YP_403513.1	Code: L; COG: COG1961
YP_403515.1	Code: L; COG: COG2801
YP_403516.1	Code: L; COG: COG1662
YP_403517.1	Code: L; COG: COG2963
YP_403519.1	Fels-1 prophage DNA or RNA helicases of superfamily II
YP_403522.1	Code: KT; COG: COG1974
YP_403523.1	adenine-specific
YP_403529.1	Code: L; COG: COG2963
YP_403531.1	Code: L; COG: COG3677
YP_403532.1	rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide
YP_403534.1	activates phage shock-protein expression; ''with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock''
YP_403535.1	''acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding''
YP_403536.1	inner membrane protein; involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF
YP_403537.2	''transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor''
YP_403538.1	Code: E; COG: COG0665
YP_403539.1	regulates genes involved in putrescine degradation
YP_403541.1	Code: L; COG: COG1662
YP_403543.1	Code: O; COG: COG0625
YP_403544.1	Code: E; COG: COG1113
YP_403545.1	Code: S; COG: COG3391
YP_403546.2	Code: P; COG: COG1629
YP_403548.1	Code: L; COG: COG1662
YP_403549.1	Code: K; COG: COG1802
YP_403550.1	Code: L; COG: COG3677
YP_403551.1	Code: L; COG: COG1662
YP_403554.1	Code: R; COG: COG1253
YP_403555.1	Code: G; COG: COG2893
YP_403556.1	hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel
YP_403557.1	Code: S; COG: COG4811
YP_403558.1	membrane protein YebN
YP_403559.1	methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth
YP_403560.1	Code: K; COG: COG1278
YP_403562.1	Code: L; COG: COG1662
YP_403566.1	Code: K; COG: COG1414
YP_403567.1	Code: GEPR; COG: COG0477
YP_403568.1	integral membrane protein; metalloprotease
YP_403569.1	Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_403570.1	affects solute and DNA transport through an unknown mechanism
YP_403571.1	Code: T; COG: COG1956
YP_403574.1	Code: L; COG: COG1662
YP_403576.1	Code: R; COG: COG3008
YP_403577.1	in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA
YP_403581.1	Code: L; COG: COG2963
YP_403582.1	Code: L; COG: COG2801
YP_403585.1	Code: L; COG: COG2963
YP_403587.1	Code: S; COG: COG4886
YP_403588.1	Code: L; COG: COG1662
YP_403589.1	Code: S; COG: COG4886
YP_403593.1	Code: L; COG: COG1662
YP_403594.1	Code: L; COG: COG2963
YP_403597.1	catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
YP_403599.1	Code: L; COG: COG1662
YP_403602.1	Converts isocitrate to alpha ketoglutarate
YP_403603.1	catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA
YP_403604.1	Code: LR; COG: COG0494
YP_403605.2	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_403606.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_403607.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_403608.1	response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress
YP_403609.1	Code: T; COG: COG0642
YP_403610.1	Code: S; COG: COG2850
YP_403611.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_403612.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_403613.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_403614.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_403615.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate
YP_403616.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_403617.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_403618.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_403619.2	''outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone''
YP_403620.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_403621.1	Code: S; COG: COG4763
YP_403622.1	mutation frequency decline; Code: LK; COG: COG1197
YP_403623.1	Code: S; COG: COG1376
YP_403625.1	Code: K; COG: COG1309
YP_403626.1	Code: S; COG: COG3134
YP_403627.1	Code: C; COG: COG1252
YP_403628.2	Code: R; COG: COG3150
YP_403629.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_403630.1	catalyzes the phosphorylation of thiamine to thiamine phosphate
YP_403631.1	Code: R; COG: COG3417
YP_403632.1	Code: R; COG: COG5633
YP_403633.1	Code: FGR; COG: COG0537
YP_403634.1	Code: P; COG: COG4773
YP_403635.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_403636.1	Code: L; COG: COG0084
YP_403637.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_403638.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_403639.1	Code: R; COG: COG1559
YP_403640.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_403641.1	''FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''
YP_403642.1	carries the fatty acid chain in fatty acid biosynthesis
YP_403643.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_403644.1	Code: I; COG: COG0331
YP_403645.1	acetylCoA ACP transacylase; FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_403646.2	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_403647.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_403648.1	Code: R; COG: COG1399
YP_403649.1	Code: L; COG: COG1662
YP_403651.1	''catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA''
YP_403653.1	membrane attachment, mRNA turnover, maturation 5S RNA; ''bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase''
YP_403655.1	flagellar biosynthesis; Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
YP_403656.1	''part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum''
YP_403657.1	flagellar biosynthesis; lipopolysaccharide layer; ''part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod''
YP_403658.1	flagellar biosynthesis; the hook connects flagellar basal body to the flagellar filament
YP_403659.1	flagellar biosynthesis; ''acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production''
YP_403660.1	flagellar biosynthesis; with FlgF and B makes up the proximal portion of the flagellar basal body rod
YP_403661.1	flagellar biosynthesis; with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella
YP_403662.1	Code: L; COG: COG1662
YP_403663.1	flagellar biosynthesis; required for the assembly of the flagellar basal body P-ring
YP_403664.1	anti-sigma factor; also known as RflB protein; regulates the flagellar specific sigma28 transcription factor
YP_403665.1	Code: R; COG: COG0728
YP_403666.1	Code: R; COG: COG0673
YP_403667.1	Code: S; COG: COG3132
YP_403668.1	Code: J; COG: COG1670
YP_403669.1	Code: L; COG: COG1662
YP_403671.1	cofactor involved in the reduction of disulfides
YP_403673.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_403675.1	Code: L; COG: COG1662
YP_403677.1	''BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing''
YP_403678.1	catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids
YP_403680.1	Code: L; COG: COG1662
YP_403681.1	activator of nucleoside metabolism
YP_403682.2	Code: L; COG: COG1662
YP_403685.1	Code: L; COG: COG3677
YP_403686.1	Code: F; COG: COG1957
YP_403687.1	Code: F; COG: COG1972
YP_403688.1	Code: G; COG: COG0524
YP_403689.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_403690.1	Code: S; COG: COG2855
YP_403691.1	Code: K; COG: COG0583
YP_403692.1	Code: E; COG: COG0833
YP_403693.1	Code: R; COG: COG0627
YP_403703.1	Code: L; COG: COG1662
YP_403704.1	Code: P; COG: COG3119
YP_403706.1	Code: L; COG: COG1662
YP_403708.1	''involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer''
YP_403710.1	galactose operon inducer; negative regulator of the mglBAC operon for galactose utilization
YP_403711.1	receptor for galactose taxis; Code: G; COG: COG1879
YP_403713.1	Code: L; COG: COG1662
YP_403714.1	Code: L; COG: COG1662
YP_403715.1	Code: L; COG: COG1662
YP_403716.1	Code: L; COG: COG3677
YP_403717.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_403718.1	Code: L; COG: COG1662
YP_403720.1	Code: L; COG: COG1662
YP_403722.1	Code: S; COG: COG2949
YP_403723.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_403724.1	Code: M; COG: COG1346
YP_403725.1	Code: R; COG: COG1380
YP_403727.1	Code: L; COG: COG1662
YP_403730.1	Code: IQR; COG: COG1028
YP_403731.1	Code: S; COG: COG0586
YP_403733.1	specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7
YP_403734.1	''component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent''
YP_403735.1	Code: G; COG: COG1472
YP_403736.1	Code: M; COG: COG1732
YP_403737.1	Code: E; COG: COG1174
YP_403739.1	Code: K; COG: COG0789
YP_403740.1	Code: T; COG: COG3275
YP_403741.1	unknown function; when overproduced it confers drug-resistance
YP_403742.1	Code: S; COG: COG4807
YP_403743.1	Code: S; COG: COG4808
YP_403745.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_403746.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_403747.1	Code: L; COG: COG2801
YP_403752.1	Code: L; COG: COG1662
YP_403755.1	Code: L; COG: COG1662
YP_403758.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_403759.2	Code: D; COG: COG0489
YP_403761.1	Code: L; COG: COG2963
YP_403762.1	Code: L; COG: COG2801
YP_403763.1	sensor BaeS; ''response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport''
YP_403764.1	Code: T; COG: COG0642
YP_403765.1	Code: GEPR; COG: COG0477
YP_403766.1	Code: L; COG: COG3547
YP_403767.1	Code: R; COG: COG4245
YP_403769.1	Code: R; COG: COG4248
YP_403770.2	Code: O; COG: COG0443
YP_403771.1	''inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine''
YP_403772.2	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_403773.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_403774.1	''YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs''
YP_403775.1	Code: S; COG: COG5606
YP_403777.1	Code: R; COG: COG1253
YP_403778.1	Code: L; COG: COG1662
YP_403779.1	''together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose''
YP_403780.1	NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose
YP_403781.1	''with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose''
YP_403782.1	Code: M; COG: COG1209
YP_403783.1	Code: M; COG: COG1898
YP_403784.1	Code: R; COG: COG2244
YP_403788.1	decarboxylating; catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_403789.1	Code: M; COG: COG1004
YP_403790.1	Code: M; COG: COG3765
YP_403791.1	phosphoribosyl-ATP pyrophosphatase; catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_403792.1	imidazole glycerol phsphate synthase holoenzyme; ''catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase''
YP_403793.2	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_403794.1	imidazole glycerol phosphate synthase holoenzyme; ''with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide''
YP_403795.2	catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate
YP_403796.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_403797.1	L-histidinol:NAD+ oxidoreductase; catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_403798.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_403799.1	Code: MG; COG: COG0451
YP_403802.1	Code: E; COG: COG0531
YP_403803.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_403804.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_403805.1	Code: O; COG: COG0425
YP_403806.1	3' --> 5' specific; deoxyribophosphodiesterase; Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
YP_403807.1	Code: L; COG: COG1662
YP_403808.1	''removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''
YP_403809.1	Code: L; COG: COG1662
YP_403810.1	Code: S; COG: COG1289
YP_403811.1	Code: S; COG: COG2926
YP_403812.1	Code: L; COG: COG1662
YP_403814.1	catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP
YP_403815.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_403816.1	''catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole''
YP_403817.1	Code: S; COG: COG1376
YP_403818.1	''Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation''
YP_403819.1	accessory regulatory circuit affecting cysM; LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB
YP_403822.1	Code: L; COG: COG3677
YP_403823.1	Code: L; COG: COG1662
YP_403824.1	Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile
YP_403825.1	Code: GEPR; COG: COG0477
YP_403828.1	Code: K; COG: COG3609
YP_403829.1	Code: R; COG: COG3668
YP_403830.1	Code: O; COG: COG0826
YP_403832.1	cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role
YP_403833.1	Code: KG; COG: COG1349
YP_403834.1	Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate
YP_403835.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_403836.1	Code: L; COG: COG1662
YP_403837.2	''catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway''
YP_403838.2	''catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate''
YP_403839.1	Code: GEPR; COG: COG0477
YP_403840.1	Code: O; COG: COG1397
YP_403841.1	Code: G; COG: COG0524
YP_403842.1	Code: K; COG: COG2188
YP_403845.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_403846.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_403847.1	Code: S; COG: COG1937
YP_403848.1	membrane protein conferring nickel and cobalt resistance
YP_403849.2	Code: S; COG: COG5455
YP_403853.1	Code: L; COG: COG1662
YP_403855.1	Code: NU; COG: COG3188
YP_403856.1	Code: L; COG: COG1662
YP_403857.1	Code: L; COG: COG3677
YP_403859.1	Code: L; COG: COG2963
YP_403860.1	Code: R; COG: COG1054
YP_403861.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_403864.1	Code: L; COG: COG2963
YP_403865.1	Code: GEPR; COG: COG0477
YP_403867.1	suppresses mutants lacking function of protein export
YP_403868.1	Code: R; COG: COG5645
YP_403869.1	synthesis of membrane-derived oligosaccharide (MDO); necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space
YP_403870.1	involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan
YP_403871.1	required for the transfer of succinyl residues to the glucan backbone
YP_403872.1	Code: I; COG: COG1502
YP_403873.1	Code: R; COG: COG2110
YP_403875.1	Code: L; COG: COG3677
YP_403876.1	Code: L; COG: COG1662
YP_403879.1	Code: S; COG: COG2353
YP_403880.1	Code: C; COG: COG3038
YP_403882.1	Code: L; COG: COG1662
YP_403883.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_403884.1	''converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers''
YP_403885.1	''phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr''
YP_403886.1	Code: L; COG: COG1662
YP_403887.1	Code: R; COG: COG0431
YP_403888.1	part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease
YP_403891.1	part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease
YP_403893.1	Code: E; COG: COG0308
YP_403894.1	catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate
YP_403895.1	''catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''
YP_403896.1	outer membrane porin F; 1a; Ia; b
YP_403897.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_403898.1	Code: R; COG: COG0491
YP_403899.1	Code: S; COG: COG3108
YP_403900.1	Code: S; COG: COG2989
YP_403901.1	Code: L; COG: COG1662
YP_403902.1	SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects
YP_403903.1	acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_403904.1	killing factor KICB; acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_403905.1	involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA
YP_403906.1	Code: S; COG: COG1434
YP_403908.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_403909.1	Code: S; COG: COG2835
YP_403910.1	Code: S; COG: COG3214
YP_403911.1	''transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate''
YP_403912.1	multicopy suppressor of htrB; involved in the transport of lipid A across the inner membrane
YP_403913.2	Code: R; COG: COG0658
YP_403914.1	IHF; site-specific recombination; ''This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control''
YP_403915.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_403916.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_403917.1	Code: O; COG: COG0501
YP_403918.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_403919.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_403920.1	Code: L; COG: COG3385
YP_403921.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_403922.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_403923.1	Code: S; COG: COG2323
YP_403925.1	formate channel 1; Code: P; COG: COG2116
YP_403926.1	Code: C; COG: COG1882
YP_403927.1	activates pyruvate formate-lyase 1 under anaerobic conditions
YP_403928.2	Code: L; COG: COG1662
YP_403929.1	Code: L; COG: COG2963
YP_403930.1	Code: GEPR; COG: COG0477
YP_403932.1	Code: R; COG: COG3302
YP_403933.1	Code: C; COG: COG0243
YP_403934.1	''catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''
YP_403935.1	Code: L; COG: COG2256
YP_403936.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_403937.1	DNA-binding membrane protein required for chromosome resolution and partitioning
YP_403938.1	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_403939.1	catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding
YP_403940.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_403941.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_403942.1	''leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys''
YP_403943.1	''stimulates the activities of the other two initiation factors, IF-2 and IF-3''
YP_403944.1	ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates
YP_403945.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_403946.1	inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible
YP_403947.1	with MacA is involved in the export of macrolide
YP_403948.2	confers macrolide resistance via active drug efflux
YP_403949.1	Code: S; COG: COG2990
YP_403950.1	Code: L; COG: COG3593
YP_403951.1	Code: L; COG: COG1662
YP_403952.1	Code: L; COG: COG3677
YP_403953.1	porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure
YP_403954.1	Code: S; COG: COG2431
YP_403955.2	catalyzes the reduction of hydroxylamine to ammonia and water
YP_403956.1	Code: C; COG: COG1018
YP_403957.1	catalyzes the formation of acetate from pyruvate
YP_403958.1	''low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine''
YP_403959.1	Code: MG; COG: COG0702
YP_403960.1	Code: MG; COG: COG0451
YP_403961.1	Code: V; COG: COG3023
YP_403962.1	Code: S; COG: COG0393
YP_403963.1	Code: L; COG: COG3677
YP_403965.1	Code: L; COG: COG1662
YP_403967.1	Code: L; COG: COG1662
YP_403969.1	With ArtMQJI transports arginine across the inner membrane
YP_403970.1	Code: ET; COG: COG0834
YP_403971.1	with ArtPMJI transports arginine across the inner membrane
YP_403972.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_403974.1	Code: L; COG: COG2801
YP_403975.1	Code: L; COG: COG2963
YP_403978.1	Code: S; COG: COG3645
YP_403979.2	Code: K; COG: COG3561
YP_403982.1	Code: L; COG: COG2801
YP_403983.1	Code: L; COG: COG2963
YP_403984.1	Code: L; COG: COG0582
YP_403985.1	Code: S; COG: COG3234
YP_403987.1	type II topoisomerase; negatively supercoils closed circular double-stranded DNA
YP_403988.1	Involved in ubiquinone biosynthesis
YP_403992.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_403993.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_403994.1	''plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases''
YP_403996.1	Code: GEPR; COG: COG0477
YP_403998.1	hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic
YP_403999.1	catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell
YP_404000.1	''anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor''
YP_404001.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_404002.1	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_404003.1	Code: S; COG: COG5464
YP_404004.1	Code: G; COG: COG3836
YP_404005.1	Code: L; COG: COG1662
YP_404007.1	Code: L; COG: COG3677
YP_404010.1	Code: L; COG: COG1662
YP_404014.1	Code: G; COG: COG0726
YP_404015.1	catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A
YP_404016.2	Code: GER; COG: COG0697
YP_404018.1	Code: IQ; COG: COG0318
YP_404019.1	conversion of chorismate to 2-o-succinylbenzoyl-CoA; ''catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate''
YP_404020.1	''catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA''
YP_404021.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_404022.1	SHCHC synthase; SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_404023.2	Code: HQ; COG: COG1169
YP_404024.1	Code: S; COG: COG4575
YP_404025.1	Code: R; COG: COG2153
YP_404026.2	member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_404027.1	Code: L; COG: COG3677
YP_404028.1	Code: L; COG: COG1662
YP_404030.1	Code: L; COG: COG1662
YP_404033.2	Catalyzes the transfer of electrons from NADH to quinone
YP_404034.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404035.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_404036.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404037.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404038.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404039.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404040.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404041.1	''shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase''
YP_404042.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404043.1	''NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms''
YP_404044.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_404045.1	Catalyzes the transfer of electrons from NADH to quinone
YP_404046.1	Code: K; COG: COG0583
YP_404047.1	''broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor''
YP_404048.1	Code: R; COG: COG1896
YP_404049.1	Code: P; COG: COG0471
YP_404050.1	Code: R; COG: COG0637
YP_404051.2	Code: S; COG: COG3013
YP_404052.1	Code: S; COG: COG3092
YP_404053.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_404054.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_404055.2	Code: S; COG: COG1288
YP_404056.1	Code: LR; COG: COG0494
YP_404057.1	Code: R; COG: COG0622
YP_404060.1	Code: O; COG: COG0625
YP_404061.1	catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate
YP_404062.1	Code: R; COG: COG1090
YP_404063.1	Code: S; COG: COG5464
YP_404066.1	Code: E; COG: COG4598
YP_404067.1	Code: E; COG: COG4160
YP_404068.1	Code: E; COG: COG4215
YP_404069.1	Code: ET; COG: COG0834
YP_404070.1	Code: ET; COG: COG0834
YP_404071.1	catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate
YP_404072.1	PRPP amidotransferase; Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_404073.1	membrane protein required for colicin V production
YP_404074.2	Code: S; COG: COG3147
YP_404075.1	dihydrofolate synthetase; Code: H; COG: COG0285
YP_404076.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_404077.1	Code: S; COG: COG0586
YP_404078.1	''mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability''
YP_404079.1	Code: E; COG: COG0136
YP_404080.1	Code: HE; COG: COG0111
YP_404081.1	in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein
YP_404083.1	''FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''
YP_404084.2	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_404086.1	Code: S; COG: COG3101
YP_404087.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_404088.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_404089.2	involved in methylation of ribosomal protein L3
YP_404090.1	Code: S; COG: COG2840
YP_404092.1	Code: NU; COG: COG3539
YP_404093.1	Code: NU; COG: COG3539
YP_404094.1	Code: NU; COG: COG3539
YP_404095.1	Code: NU; COG: COG3121
YP_404099.1	Code: L; COG: COG1662
YP_404100.1	Code: L; COG: COG3677
YP_404101.1	Code: T; COG: COG2062
YP_404102.1	multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate
YP_404103.1	FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth
YP_404104.1	Code: S; COG: COG3691
YP_404105.1	transport of long-chain fatty acids; sensitivity to phage T2; Code: I; COG: COG2067
YP_404108.1	Code: L; COG: COG1662
YP_404109.1	Code: L; COG: COG3677
YP_404110.1	Code: M; COG: COG2853
YP_404111.1	Code: P; COG: COG2116
YP_404112.1	Code: L; COG: COG1662
YP_404113.1	Code: L; COG: COG3677
YP_404114.1	Code: L; COG: COG1662
YP_404115.1	Code: G; COG: COG1621
YP_404116.1	Code: K; COG: COG1609
YP_404118.1	deaminase; catalyzes the formation of pyruvate from serine
YP_404119.1	Code: GEPR; COG: COG0477
YP_404120.1	Code: V; COG: COG1566
YP_404121.1	Code: L; COG: COG1662
YP_404122.1	Code: L; COG: COG1662
YP_404123.1	Code: L; COG: COG3677
YP_404124.1	Code: C; COG: COG1804
YP_404125.1	member of the AEC family of auxin efflux transporters; unknown function
YP_404126.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_404127.1	catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA
YP_404131.2	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock
YP_404132.1	Code: E; COG: COG0436
YP_404134.1	Code: T; COG: COG3275
YP_404135.1	metalloprotein
YP_404136.1	Code: E; COG: COG0006
YP_404137.1	Code: G; COG: COG1299
YP_404138.1	Code: G; COG: COG1445
YP_404139.1	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate
YP_404140.1	Code: P; COG: COG1914
YP_404141.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_404145.1	Code: F; COG: COG1972
YP_404148.1	Code: L; COG: COG0675
YP_404149.1	Code: L; COG: COG1943
YP_404150.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_404152.1	Code: R; COG: COG0385
YP_404153.1	Code: S; COG: COG3530
YP_404154.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_404155.1	interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_404156.1	role in sulfur assimilation
YP_404157.1	O-acetylserine sulfhydrolase A; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis
YP_404158.1	Code: G; COG: COG1925
YP_404159.1	''Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system''
YP_404160.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_404161.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_404163.1	O-acetylserine sulfhydrolase B; catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide
YP_404164.1	chromate resistance; Code: P; COG: COG1118
YP_404165.1	Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import
YP_404166.1	Code: O; COG: COG0555
YP_404167.1	Code: P; COG: COG4150
YP_404168.2	Code: IQR; COG: COG1028
YP_404169.1	Code: K; COG: COG1737
YP_404170.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_404171.1	belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component
YP_404174.1	Code: P; COG: COG2837
YP_404177.2	Code: R; COG: COG0456
YP_404178.1	Code: M; COG: COG0860
YP_404179.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_404180.1	activates the transcription of the ethanolamine utilization operon
YP_404181.1	Code: QC; COG: COG4577
YP_404182.1	Code: E; COG: COG4816
YP_404183.1	catalyzes the formation of acetaldehyde from ethanolamine
YP_404189.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_404190.1	Code: L; COG: COG1662
YP_404192.1	Code: LR; COG: COG0494
YP_404193.1	''unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)''
YP_404194.1	Code: L; COG: COG1662
YP_404195.1	protein histidine kinase (acts on NarP and narL); Code: T; COG: COG3850
YP_404196.1	sensitivity to acriflavine, integral membrane protein, possible efflux pump; Code: V; COG: COG0841
YP_404197.1	Code: P; COG: COG1393
YP_404198.1	''dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.''
YP_404202.1	Code: L; COG: COG1662
YP_404203.1	Code: R; COG: COG1444
YP_404206.1	SAICAR synthetase; catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_404208.1	Code: M; COG: COG3317
YP_404209.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_404210.2	negative transcriptional regulator of the gcvTHP operon
YP_404211.1	bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine
YP_404212.1	Code: C; COG: COG1142
YP_404213.1	Code: CP; COG: COG0651
YP_404214.1	Code: C; COG: COG0650
YP_404215.1	interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide
YP_404216.1	Code: CP; COG: COG0651
YP_404217.1	Code: C; COG: COG3261
YP_404218.1	Code: C; COG: COG3260
YP_404220.1	formate channel 2; inner membrane protein presumed to act as a formate transporter; member of the hyf operon
YP_404221.1	Code: R; COG: COG0628
YP_404222.1	Code: R; COG: COG4783
YP_404223.1	Code: P; COG: COG1393
YP_404224.1	''controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP''
YP_404225.1	Code: F; COG: COG2233
YP_404226.2	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_404227.1	AIR synthetase; catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_404228.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_404229.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_404230.1	Code: FP; COG: COG0248
YP_404231.2	Code: L; COG: COG1662
YP_404233.1	Code: L; COG: COG1662
YP_404236.1	Code: L; COG: COG1662
YP_404237.1	Code: M; COG: COG3133
YP_404238.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_404239.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_404241.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_404242.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_404243.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_404245.2	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_404246.1	''with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis''
YP_404247.1	Code: S; COG: COG2976
YP_404248.1	''catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG''
YP_404249.1	''catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis''
YP_404250.1	Code: S; COG: COG1426
YP_404251.1	Code: R; COG: COG0820
YP_404252.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_404253.2	catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds
YP_404254.2	enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I
YP_404255.2	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_404256.1	Code: S; COG: COG2975
YP_404257.1	Code: C; COG: COG0633
YP_404258.1	heat shock protein, chaperone, member of Hsp70 protein family; involved in the maturation of iron-sulfur cluster-containing proteins
YP_404259.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_404260.1	forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein
YP_404261.1	Code: C; COG: COG0822
YP_404262.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_404263.1	regulates the expression of the iscRSUA operon
YP_404264.1	Code: J; COG: COG0565
YP_404265.1	enhances synthesis of sigma32 in mutant; extragenic suppressor, may modulate RNAse III lethal action; Code: G; COG: COG0483
YP_404266.1	Code: R; COG: COG1073
YP_404267.2	Code: K; COG: COG3711
YP_404268.1	transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_404270.1	Code: L; COG: COG1662
YP_404273.1	Code: L; COG: COG1662
YP_404274.1	Code: KG; COG: COG1940
YP_404275.1	''catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate''
YP_404276.1	flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine
YP_404277.1	''indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA''
YP_404278.1	Code: T; COG: COG2204
YP_404280.1	Code: T; COG: COG0642
YP_404281.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_404282.1	''YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function''
YP_404283.1	Code: FJ; COG: COG0590
YP_404284.2	Code: E; COG: COG0560
YP_404285.2	Code: K; COG: COG1737
YP_404286.1	Code: L; COG: COG1961
YP_404287.1	Code: S; COG: COG4886
YP_404289.1	Code: L; COG: COG2963
YP_404295.1	Code: L; COG: COG1662
YP_404297.1	Code: L; COG: COG3677
YP_404299.1	DAHP synthetase, tyrosine repressible; ''catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive''
YP_404300.1	prephenate dehydrogenase; catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_404301.1	prephenate dehydratase; catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_404302.1	associated with 30S ribosomal subunit; interferes with translation elongation
YP_404304.1	Code: L; COG: COG2963
YP_404305.1	Code: L; COG: COG2801
YP_404308.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_404310.1	Code: L; COG: COG1662
YP_404314.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_404315.1	tRNA (guanine-7-)-methyltransferase; methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_404316.2	Essential for efficient processing of 16S rRNA
YP_404317.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_404318.1	binds to signal sequence, GTP and RNA; with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins
YP_404319.1	Code: R; COG: COG4137
YP_404320.2	Code: P; COG: COG4536
YP_404321.1	phage lambda replication; host DNA synthesis; heat shock protein; protein repair; with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_404322.1	catalyzes the phosphorylation of NAD to NADP
YP_404323.1	Code: L; COG: COG0497
YP_404324.2	Code: J; COG: COG2913
YP_404325.2	Code: S; COG: COG2914
YP_404326.1	Code: I; COG: COG2867
YP_404327.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_404331.1	Code: L; COG: COG1662
YP_404332.1	Code: KL; COG: COG0553
YP_404335.1	Code: C; COG: COG1145
YP_404336.1	Code: L; COG: COG1662
YP_404338.1	''Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids''
YP_404339.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_404340.1	protein interacts with RecR and possibly RecF proteins; involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_404341.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_404342.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_404343.1	catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins
YP_404344.1	may be inner membrane protein; binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_404345.1	involved in the reduction of the SoxR iron-sulfur cluster
YP_404346.1	periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
YP_404347.1	Code: T; COG: COG3073
YP_404348.1	sigma-E factor; heat shock and oxidative stress; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_404349.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_404350.1	Code: R; COG: COG4123
YP_404351.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_404352.1	Code: K; COG: COG0583
YP_404353.1	Code: L; COG: COG2963
YP_404355.1	Code: E; COG: COG1280
YP_404356.1	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_404357.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_404358.1	Code: J; COG: COG0566
YP_404359.1	Code: OC; COG: COG0526
YP_404360.1	Code: S; COG: COG3148
YP_404361.1	Code: C; COG: COG1042
YP_404362.1	phospholipid synthesis; catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_404363.1	Code: R; COG: COG5544
YP_404364.1	Code: GEPR; COG: COG0477
YP_404365.1	Code: O; COG: COG0542
YP_404366.1	Code: S; COG: COG1496
YP_404367.1	''responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA''
YP_404368.1	''with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline''
YP_404369.1	Code: L; COG: COG3385
YP_404371.1	Code: L; COG: COG3436
YP_404372.1	Code: L; COG: COG2801
YP_404373.1	Code: L; COG: COG2963
YP_404375.1	Code: L; COG: COG2963
YP_404376.1	Code: L; COG: COG2801
YP_404377.1	Code: L; COG: COG1662
YP_404379.1	Code: L; COG: COG1662
YP_404380.1	Code: L; COG: COG3677
YP_404381.1	Code: E; COG: COG1113
YP_404382.2	regulator of gab gene expression
YP_404383.1	Code: S; COG: COG1652
YP_404384.1	Code: S; COG: COG0401
YP_404385.1	Code: K; COG: COG0640
YP_404386.1	Code: P; COG: COG0607
YP_404387.1	H-NS-like protein; chaperone activity; possibly involved in RNA splicing; Code: R; COG: COG2916
YP_404391.1	Code: S; COG: COG4575
YP_404392.1	Code: KE; COG: COG1167
YP_404393.1	Code: S; COG: COG2128
YP_404394.1	hydrogen donor; Code: O; COG: COG0695
YP_404395.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_404397.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_404398.1	Code: L; COG: COG1662
YP_404399.1	Code: L; COG: COG3677
YP_404400.1	Code: E; COG: COG4175
YP_404401.1	with ProVX is involved in the high-affinity uptake of glycine betaine
YP_404402.1	Code: L; COG: COG1662
YP_404403.1	major facilitator superfamily; Code: GEPR; COG: COG0477
YP_404404.1	Code: E; COG: COG1296
YP_404406.1	microcin B17 synthesis; DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB
YP_404407.1	Code: V; COG: COG1566
YP_404409.1	Code: J; COG: COG0617
YP_404410.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_404411.1	involved in the first step of glutathione biosynthesis
YP_404413.1	''YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent''
YP_404414.1	affects carbohydrate metabolism; has regulatory role in many processes
YP_404415.1	''Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''
YP_404416.1	regulator; binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_404417.1	DNA strand exchange and renaturation; ''catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs''
YP_404418.1	Code: R; COG: COG1546
YP_404419.1	membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan
YP_404420.1	one of two; Code: G; COG: COG3730
YP_404422.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_404423.1	catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate
YP_404424.1	regulator for glucitol utilization
YP_404425.1	regulator for gut (srl) operon; regulates genes involved in glucitol utilization
YP_404426.2	catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate
YP_404427.2	Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon
YP_404428.1	detoxifies nitric oxide using NADH
YP_404429.1	catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase
YP_404430.1	Code: O; COG: COG0068
YP_404431.1	Code: K; COG: COG1609
YP_404432.1	cryptic protein; Code: G; COG: COG2723
YP_404433.1	Code: K; COG: COG5499
YP_404434.1	protease involved in processing C-terminal end of the large subunit of hydrogenase 3; involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE
YP_404435.1	processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex)
YP_404436.1	part of FHL complex; ''electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate''
YP_404437.1	part of FHL complex; Code: C; COG: COG3261
YP_404439.1	part of formate hydrogenlyase (FHL) complex; Code: C; COG: COG1142
YP_404440.1	regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon
YP_404441.1	plays a role in hydrogenase nickel cofactor insertion
YP_404442.1	functions as nickel donor for large subunit of hydrogenase 3; GTP hydrolase involved in nickel liganding into hydrogenases
YP_404443.1	''HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase''
YP_404444.1	Code: O; COG: COG0409
YP_404445.1	plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309
YP_404446.1	Code: L; COG: COG2801
YP_404447.1	Code: L; COG: COG2963
YP_404448.1	Code: R; COG: COG2005
YP_404450.1	This protein performs the mismatch recognition step during the DNA repair process
YP_404451.1	Code: L; COG: COG1662
YP_404452.1	Code: L; COG: COG3677
YP_404455.1	Code: H; COG: COG0163
YP_404456.1	Code: K; COG: COG1846
YP_404457.1	sigma38 factor; synthesis of many growth phase related proteins; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses
YP_404458.1	outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus
YP_404459.1	catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins
YP_404460.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_404461.1	catalyzes the modification of U13 in tRNA(Glu)
YP_404462.1	''catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate''
YP_404463.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_404464.1	forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein
YP_404466.1	converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis
YP_404467.1	ATP:sulfate adenylyltransferase; probably a GTPase; may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ
YP_404468.1	ATP:sulfate adenylyltransferase; probably a GTPase; with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_404469.1	alkaline phosphatase isozyme conversion; catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3
YP_404473.1	Code: L; COG: COG3677
YP_404474.1	Code: L; COG: COG1662
YP_404477.1	Code: L; COG: COG2963
YP_404478.1	Code: L; COG: COG2801
YP_404479.1	Code: L; COG: COG1662
YP_404480.1	Code: L; COG: COG3677
YP_404481.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_404482.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_404483.1	catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity
YP_404484.1	Code: H; COG: COG0720
YP_404485.1	Code: C; COG: COG0644
YP_404486.1	Code: C; COG: COG2440
YP_404487.1	Code: K; COG: COG1954
YP_404488.1	Code: GEPR; COG: COG0477
YP_404490.1	Code: L; COG: COG1662
YP_404491.1	Code: IQR; COG: COG1028
YP_404492.1	Code: G; COG: COG1070
YP_404493.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_404494.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_404495.1	Code: O; COG: COG0602
YP_404497.1	Code: L; COG: COG1662
YP_404500.1	Code: L; COG: COG1662
YP_404501.1	Code: L; COG: COG2963
YP_404504.1	Code: L; COG: COG2963
YP_404506.1	Code: R; COG: COG1512
YP_404507.1	Code: L; COG: COG1662
YP_404508.1	Code: L; COG: COG3677
YP_404510.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_404511.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_404512.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era
YP_404513.1	autoregulated; MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system
YP_404514.1	autoregulated; part of the MazF-MazE toxin-antitoxin system; conteracts MazF
YP_404515.1	GTP pyrophosphokinase; regulation of RNA synthesis; stringent factor; (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP
YP_404516.1	in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]
YP_404517.1	activates OmpR by phophorylation; part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system
YP_404518.1	''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''
YP_404519.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_404520.1	Code: S; COG: COG3098
YP_404521.1	interacts with secY; SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function
YP_404522.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_404523.1	Code: R; COG: COG1611
YP_404524.1	Code: E; COG: COG0814
YP_404525.1	deaminase, L-SD2; Code: E; COG: COG1760
YP_404526.1	has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups
YP_404527.1	Code: C; COG: COG1454
YP_404528.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_404529.1	Code: L; COG: COG1662
YP_404530.1	catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose
YP_404531.1	Code: G; COG: COG1070
YP_404532.1	Code: G; COG: COG4154
YP_404533.1	regulates expression of genes involved in L-fucose utilization
YP_404534.1	Code: R; COG: COG2933
YP_404535.1	Code: S; COG: COG2363
YP_404536.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_404538.1	Code: E; COG: COG0520
YP_404539.1	Code: R; COG: COG2166
YP_404540.1	Code: H; COG: COG1179
YP_404541.1	''membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues''
YP_404542.1	Code: M; COG: COG0860
YP_404543.1	amino acid acetyltransferase; catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis
YP_404544.1	DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_404545.1	DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_404546.1	Code: O; COG: COG1025
YP_404547.1	DNA helicase; ssDNA endonuclease; catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination
YP_404548.1	Code: NU; COG: COG4967
YP_404550.1	Code: U; COG: COG4795
YP_404551.1	Code: NU; COG: COG2165
YP_404552.1	''ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived''
YP_404553.1	a major membrane phospholipid; transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_404554.1	member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr
YP_404555.1	hydrolyzes diadenosine polyphosphate
YP_404556.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_404557.1	Code: P; COG: COG0861
YP_404559.1	complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH
YP_404560.1	Code: GEPR; COG: COG0477
YP_404561.1	acyl-acyl-carrier protein synthetase; Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
YP_404562.1	controls transcription of galETKM
YP_404563.1	catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding
YP_404564.1	activates the transcription of the lysA gene encoding diaminopimelate decarboxylase
YP_404565.1	Code: M; COG: COG1794
YP_404566.1	Code: GEPR; COG: COG0477
YP_404567.1	Code: L; COG: COG1662
YP_404568.1	Code: L; COG: COG3677
YP_404569.2	''methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate''
YP_404570.1	Code: C; COG: COG1979
YP_404571.1	Code: K; COG: COG2207
YP_404572.1	Code: S; COG: COG0586
YP_404573.1	beta-cystathionase; catalyzes the formation of L-homocysteine from cystathionine
YP_404575.1	uptake of enterochelin; tonB-dependent uptake of B colicins; membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_404576.1	uptake of enterochelin; tonB-dependent uptake of B colicins; membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_404577.1	Code: IQR; COG: COG1028
YP_404578.1	Code: S; COG: COG2862
YP_404579.1	Code: L; COG: COG1662
YP_404580.1	Code: L; COG: COG3677
YP_404581.1	Code: C; COG: COG0667
YP_404583.1	involved in hydrogen uptake
YP_404584.1	Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2
YP_404585.1	''HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits''
YP_404586.1	involved in hydrogen uptake
YP_404587.1	protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC)
YP_404589.1	may modulate levels of hydrogenase-2; plays a role in hydrogenase nickel cofactor insertion
YP_404590.1	may effect maturation of large subunit of hydrogenase-2; Code: O; COG: COG0298
YP_404591.1	YghU; B2989; one of eight  glutathione transferases from E. coli
YP_404592.1	catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction
YP_404593.1	Code: P; COG: COG0306
YP_404595.1	Code: L; COG: COG3677
YP_404596.1	Code: MG; COG: COG0702
YP_404597.2	activates fatty acids by binding to coenzyme A
YP_404598.1	Code: L; COG: COG1662
YP_404599.1	''part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm''
YP_404600.1	Code: NU; COG: COG1450
YP_404601.1	Code: NU; COG: COG2804
YP_404602.1	Code: NU; COG: COG1459
YP_404603.1	Code: NU; COG: COG2165
YP_404605.1	Code: NU; COG: COG2165
YP_404606.1	Code: U; COG: COG4795
YP_404607.1	Code: U; COG: COG3156
YP_404608.1	similar to general secretory pathway protein L
YP_404610.1	Code: L; COG: COG3677
YP_404611.1	Code: L; COG: COG1662
YP_404612.1	Code: E; COG: COG1982
YP_404613.1	permease; Code: GEPR; COG: COG0477
YP_404614.1	''Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues''
YP_404615.1	Code: CO; COG: COG2924
YP_404616.1	G.C --> T.A transversions; Code: L; COG: COG1194
YP_404617.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_404618.2	Code: S; COG: COG3171
YP_404620.1	''catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis''
YP_404622.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_404623.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_404624.2	Code: S; COG: COG1872
YP_404625.1	Code: S; COG: COG0762
YP_404626.1	Code: R; COG: COG0325
YP_404627.1	Code: NU; COG: COG2805
YP_404628.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_404629.2	Code: K; COG: COG1678
YP_404630.1	''The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione''
YP_404631.2	''in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase''
YP_404632.1	Code: L; COG: COG2356
YP_404633.1	Code: S; COG: COG3091
YP_404634.1	Code: GEPR; COG: COG0477
YP_404635.1	AdoMet synthetase; methyl and propylamine donor, corepressor of met genes; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_404639.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_404642.1	Code: L; COG: COG1662
YP_404644.1	catalyzes the formation of putrescine from agmatine
YP_404645.1	Code: O; COG: COG0501
YP_404646.1	''catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase''
YP_404647.1	Code: L; COG: COG1662
YP_404648.1	''TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein''
YP_404649.1	Code: G; COG: COG2213
YP_404650.2	Code: ER; COG: COG1063
YP_404651.1	Code: K; COG: COG3722
YP_404652.1	Code: H; COG: COG1072
YP_404653.1	Code: P; COG: COG1118
YP_404656.1	Code: P; COG: COG0619
YP_404658.1	Code: R; COG: COG1661
YP_404659.1	NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate
YP_404660.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_404661.1	''catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate''
YP_404662.1	participates in the regulation of osmotic pressure changes within the cel
YP_404663.1	Involved in the export of arginine
YP_404664.1	Code: S; COG: COG2968
YP_404666.1	Code: L; COG: COG1662
YP_404668.1	binds to 13-mers at oriC; specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport
YP_404669.1	Code: L; COG: COG1662
YP_404671.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_404672.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_404673.1	ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function
YP_404674.1	Code: S; COG: COG3027
YP_404675.2	the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown
YP_404676.1	exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide
YP_404677.1	2-octaprenyl-6-methoxyphenol--> 2-octaprenyl-6-methoxy-1, 4-benzoquinone; ''Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone''
YP_404678.1	Code: HC; COG: COG0654
YP_404679.1	T protein; tetrahydrofolate-dependent; ''catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein''
YP_404680.1	''part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor''
YP_404681.1	P protein of glycine cleavage system; acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_404682.1	Code: S; COG: COG3097
YP_404683.1	Code: L; COG: COG1662
YP_404684.1	Code: R; COG: COG1272
YP_404685.1	physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator
YP_404686.1	Code: S; COG: COG2938
YP_404688.1	''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic''
YP_404689.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_404690.1	DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity
YP_404691.1	5'-3' single-stranded-DNA-specific exonuclease
YP_404692.1	Code: J; COG: COG1186
YP_404693.1	suppressor of ColE1 mutation in primer RNA; ''class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1''
YP_404694.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_404695.1	Code: L; COG: COG3677
YP_404696.1	Code: L; COG: COG2963
YP_404697.1	Code: L; COG: COG2801
YP_404700.1	Code: L; COG: COG1662
YP_404701.1	Code: P; COG: COG0428
YP_404702.1	Code: E; COG: COG0754
YP_404703.2	Code: S; COG: COG5463
YP_404705.2	specific tolerance to colicin E1; segregation of daughter chromosomes; trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell
YP_404706.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_404707.1	Code: S; COG: COG3151
YP_404708.1	Code: R; COG: COG1409
YP_404709.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_404710.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_404711.1	Code: S; COG: COG1359
YP_404712.1	Code: R; COG: COG2249
YP_404713.1	Code: T; COG: COG0642
YP_404714.1	response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes
YP_404715.1	Code: S; COG: COG3111
YP_404716.1	Code: L; COG: COG3449
YP_404717.1	YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system
YP_404718.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_404719.1	Code: I; COG: COG0204
YP_404720.1	Code: Q; COG: COG2132
YP_404721.1	Code: M; COG: COG4238
YP_404723.1	Code: L; COG: COG1662
YP_404724.1	Code: L; COG: COG3677
YP_404725.1	DHBP synthase; functions during riboflavin biosynthesis
YP_404726.1	Code: S; COG: COG2960
YP_404727.1	Involved in glycogen synthesis. May be involved in glycogen priming
YP_404728.1	Code: L; COG: COG1662
YP_404729.1	Code: L; COG: COG1662
YP_404730.1	Code: L; COG: COG3677
YP_404732.1	Code: L; COG: COG1662
YP_404733.1	Code: S; COG: COG2268
YP_404734.1	''catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose''
YP_404735.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_404736.1	Code: S; COG: COG3025
YP_404737.1	Code: T; COG: COG3103
YP_404738.1	''catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases''
YP_404739.1	''catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin''
YP_404740.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_404741.1	Code: L; COG: COG1662
YP_404742.1	Code: P; COG: COG0471
YP_404743.1	''in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity''
YP_404744.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_404745.1	DNA biosynthesis; synthesizes RNA primers at the replication forks
YP_404746.1	regulation of proteins induced at high temperatures; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_404747.1	Code: L; COG: COG3663
YP_404748.1	Code: P; COG: COG2375
YP_404749.1	Code: K; COG: COG1695
YP_404750.1	Code: NT; COG: COG0840
YP_404751.1	Code: R; COG: COG0073
YP_404752.1	Code: K; COG: COG1609
YP_404753.1	Code: L; COG: COG1662
YP_404756.1	Code: C; COG: COG1902
YP_404757.1	Code: K; COG: COG5499
YP_404758.1	Code: J; COG: COG2813
YP_404759.1	Code: R; COG: COG1451
YP_404761.1	Code: L; COG: COG1662
YP_404762.1	Code: R; COG: COG0673
YP_404763.1	Code: P; COG: COG0861
YP_404764.1	involved in the import of serine and threonine coupled with the import of sodium
YP_404766.1	Code: G; COG: COG2721
YP_404767.1	Code: GEPR; COG: COG0477
YP_404768.1	Code: L; COG: COG1662
YP_404769.1	Code: L; COG: COG3677
YP_404770.2	''regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.''
YP_404771.1	Code: S; COG: COG0586
YP_404774.1	Code: S; COG: COG4575
YP_404775.1	Code: S; COG: COG5393
YP_404777.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_404778.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_404779.2	Code: S; COG: COG2259
YP_404780.1	Code: O; COG: COG0435
YP_404781.1	Code: S; COG: COG3152
YP_404782.1	Code: L; COG: COG1662
YP_404783.1	Code: L; COG: COG3677
YP_404784.1	Code: L; COG: COG1662
YP_404785.1	Code: K; COG: COG0583
YP_404786.1	Code: R; COG: COG1741
YP_404788.1	Code: S; COG: COG3681
YP_404789.1	Code: E; COG: COG0814
YP_404790.1	Code: L; COG: COG1662
YP_404791.1	Code: L; COG: COG3677
YP_404792.2	Code: E; COG: COG1760
YP_404793.1	Code: C; COG: COG1882
YP_404794.1	catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism
YP_404795.1	involved in the import of threonine and serine in combination with the import of a proton
YP_404796.1	catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic
YP_404797.1	regulates the tdcABCDEFG operon which is involved in amino acid degradation
YP_404798.1	participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon
YP_404801.1	Code: L; COG: COG1662
YP_404802.1	Code: L; COG: COG3677
YP_404803.1	Code: L; COG: COG1662
YP_404804.2	Code: G; COG: COG1929
YP_404805.2	catalyzes the reduction of tartronate semialdehyde to glycerate
YP_404806.1	cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate
YP_404807.1	Code: L; COG: COG3677
YP_404808.1	Code: L; COG: COG1662
YP_404809.1	Code: NU; COG: COG3539
YP_404810.1	Code: R; COG: COG0313
YP_404811.1	Code: R; COG: COG3107
YP_404812.1	Code: L; COG: COG0792
YP_404813.1	Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein
YP_404814.1	Code: R; COG: COG2823
YP_404815.1	Code: MG; COG: COG0702
YP_404816.1	Code: R; COG: COG0693
YP_404817.1	Code: S; COG: COG3787
YP_404818.1	Code: L; COG: COG2827
YP_404819.1	Code: R; COG: COG3153
YP_404820.1	Code: I; COG: COG3154
YP_404821.1	Code: O; COG: COG0826
YP_404822.1	Code: O; COG: COG0826
YP_404823.1	Code: C; COG: COG2141
YP_404824.1	tryptophan transporter of high affinity
YP_404825.2	participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division
YP_404826.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_404827.1	cytidylate kinase activity; Code: J; COG: COG1185
YP_404828.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_404829.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_404830.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_404831.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_404832.1	L factor; ''modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination''
YP_404833.2	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_404834.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_404835.2	Code: R; COG: COG2194
YP_404838.1	Code: U; COG: COG1314
YP_404839.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_404840.2	''catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate''
YP_404841.1	degrades sigma32, integral membrane peptidase, cell division protein; inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins
YP_404842.1	Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit
YP_404843.1	RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability
YP_404844.2	cleaves 3' nucleotide of paused mRNA; ''necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus''
YP_404845.1	penicillin-binding protein 4; ''penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains''
YP_404846.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_404847.1	Code: GER; COG: COG0697
YP_404848.1	involved in the peptidyltransferase reaction during translation
YP_404849.1	Code: J; COG: COG0261
YP_404850.1	Code: H; COG: COG0142
YP_404851.1	activator of maltose metabolism genes
YP_404852.1	first step in murein biosynthesis; adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_404853.1	Code: K; COG: COG5007
YP_404854.2	Code: R; COG: COG3113
YP_404855.1	Code: Q; COG: COG2854
YP_404856.1	Code: Q; COG: COG1463
YP_404857.1	Code: Q; COG: COG0767
YP_404858.1	ATP-binding subunit of a  ABC toluene efflux transporter
YP_404859.1	YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers
YP_404860.1	Code: M; COG: COG0794
YP_404861.1	forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis
YP_404862.1	Code: S; COG: COG3117
YP_404863.1	''LptA; periplasmic binding protein part of a  ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system''
YP_404864.1	Code: R; COG: COG1137
YP_404865.1	nitrogen and fermentation regulation; ''sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen''
YP_404866.1	YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing
YP_404867.1	regulates N metabolism; Code: GT; COG: COG1762
YP_404868.1	Code: R; COG: COG1660
YP_404869.1	nitrogen related, exchanges phosphate with Enzyme I, Hpr; Code: G; COG: COG1925
YP_404871.1	glycosyltransferase; polymerizes glycan strands in the peptidoglycan
YP_404872.1	SCRP-27A; Code: Q; COG: COG3155
YP_404873.1	histidine protein kinase/phosphatase, sensor for arcA; sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA
YP_404874.1	Code: R; COG: COG1242
YP_404875.1	catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
YP_404876.1	''glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate''
YP_404877.1	Code: S; COG: COG4804
YP_404878.1	Code: G; COG: COG2731
YP_404879.2	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_404880.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_404881.2	Code: GEPR; COG: COG0477
YP_404882.1	aldolase; catabolism of sialic acid; not K12?; catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid
YP_404883.1	Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization
YP_404885.1	Code: R; COG: COG2969
YP_404886.1	regulator of transcription; transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation
YP_404887.1	forms a direct contact with the tRNA during translation
YP_404888.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_404889.1	Code: R; COG: COG1485
YP_404890.1	Code: S; COG: COG3105
YP_404891.1	Code: O; COG: COG0265
YP_404892.1	Code: O; COG: COG0265
YP_404893.1	oxidizes malate to oxaloacetate
YP_404894.1	cer-mediated site-specific recombination; regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_404896.1	Code: K; COG: COG2732
YP_404897.1	with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_404898.1	''with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate''
YP_404899.2	membrane protein AaeX; the gene is a member of the aaeXAB operon
YP_404900.1	Code: K; COG: COG0583
YP_404901.1	''responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA''
YP_404902.1	Code: S; COG: COG3164
YP_404903.2	involved in the processing of the 5'end of 16S rRNA
YP_404904.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_404905.1	part of cell wall structural complex MreBCD; transmembrane component
YP_404906.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_404907.2	regulator of ftsI; septation function; functions in MreBCD complex in some organisms
YP_404908.1	regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules
YP_404909.1	Code: CR; COG: COG0604
YP_404913.1	carrier of biotin; ''composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism''
YP_404914.1	''an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism''
YP_404915.1	Code: S; COG: COG3924
YP_404916.2	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_404917.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_404918.1	Code: J; COG: COG0042
YP_404919.1	DNA-binding protein; a trans activator for transcription; Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_404920.1	Code: L; COG: COG3677
YP_404921.1	Code: L; COG: COG1662
YP_404923.1	Code: L; COG: COG3677
YP_404924.1	Code: ET; COG: COG0834
YP_404925.1	Code: E; COG: COG0765
YP_404926.2	Code: R; COG: COG0663
YP_404928.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_404929.1	RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA
YP_404930.1	Code: L; COG: COG0551
YP_404931.1	Code: S; COG: COG2922
YP_404932.1	involved in DNA uptake; Code: LU; COG: COG0758
YP_404933.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_404934.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_404935.1	catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase
YP_404936.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_404937.1	mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators
YP_404939.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_404940.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_404941.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_404942.1	''located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3''
YP_404943.1	''located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA''
YP_404944.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_404945.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_404946.1	late assembly protein
YP_404947.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_404948.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_404949.1	binds 5S rRNA along with protein L5 and L25
YP_404950.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_404951.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_404952.1	''located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif''
YP_404953.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_404954.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_404955.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_404956.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_404957.1	one of the stabilizing components for the large ribosomal subunit
YP_404958.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_404959.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_404960.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_404961.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_404962.1	''one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation''
YP_404963.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_404964.1	regulates expression of S10 operon; L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_404965.1	''binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin''
YP_404966.1	''NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex''
YP_404967.1	an iron storage homoprotein; iron storage protein
YP_404968.1	Code: P; COG: COG2906
YP_404969.1	duplicate of tufB; ''EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu''
YP_404970.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_404971.1	initiates assembly; binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_404972.1	''interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance''
YP_404973.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_404974.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_404975.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_404976.1	Code: S; COG: COG2964
YP_404977.1	rotamase
YP_404978.1	Code: S; COG: COG2900
YP_404979.1	rotamase
YP_404980.1	Code: R; COG: COG3529
YP_404981.1	K+ efflux; Code: P; COG: COG1226
YP_404982.1	required for KefB activity
YP_404983.1	Code: R; COG: COG0488
YP_404984.1	Code: R; COG: COG0429
YP_404985.1	Code: S; COG: COG3089
YP_404986.1	Code: O; COG: COG1765
YP_404987.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_404988.1	Code: S; COG: COG1289
YP_404989.1	''DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate''
YP_404990.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_404991.1	induced in stationary phase, recognized by rpoS, affects cell division; Code: D; COG: COG2184
YP_404993.1	rotamase A; Code: O; COG: COG0652
YP_404994.1	Code: GEPR; COG: COG0477
YP_404995.1	Code: C; COG: COG1251
YP_404996.1	''involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations''
YP_404997.1	member of the FNT family of formate and nitrite transporters
YP_404998.1	sirohaeme biosynthesis; ''multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin''
YP_404999.1	Code: L; COG: COG1662
YP_405000.1	Code: E; COG: COG0076
YP_405001.1	regulates genes in response to acid and/or during stationary phase
YP_405002.1	Code: L; COG: COG1662
YP_405004.1	Code: V; COG: COG0841
YP_405005.1	''with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds''
YP_405006.1	Code: K; COG: COG2771
YP_405007.1	Code: L; COG: COG3677
YP_405008.1	Code: L; COG: COG1662
YP_405009.1	Code: S; COG: COG3247
YP_405010.1	inactive form
YP_405012.1	Code: L; COG: COG1662
YP_405013.1	with HmuTU is involved in the transport of hemin
YP_405014.1	Code: P; COG: COG0609
YP_405015.1	Code: MG; COG: COG0702
YP_405016.1	Code: P; COG: COG3721
YP_405017.1	Code: P; COG: COG4558
YP_405019.1	Code: P; COG: COG1629
YP_405020.1	Code: P; COG: COG3720
YP_405021.1	Code: K; COG: COG2771
YP_405022.1	Code: M; COG: COG3065
YP_405023.1	Code: L; COG: COG1662
YP_405024.1	Code: P; COG: COG1393
YP_405025.1	Code: P; COG: COG1055
YP_405026.1	regulates the expression of of the arsRBC involved in resistance to arsenic
YP_405027.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_405028.1	Code: R; COG: COG2961
YP_405029.1	Code: E; COG: COG0339
YP_405030.1	predicted SAM-dependent methyltransferase
YP_405032.1	Code: T; COG: COG0589
YP_405033.1	''ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress''
YP_405034.1	Code: P; COG: COG0306
YP_405035.1	Code: R; COG: COG2081
YP_405039.1	Code: G; COG: COG0058
YP_405040.1	''catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose''
YP_405041.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_405042.1	part of glycogen operon, a glycosyl hydrolase, debranching enzyme; ''catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen''
YP_405043.1	''catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain''
YP_405044.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_405045.1	''YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP)''
YP_405046.1	Code: LU; COG: COG0758
YP_405048.1	Code: L; COG: COG1662
YP_405049.1	Code: L; COG: COG3677
YP_405050.1	Code: L; COG: COG1662
YP_405051.1	Code: L; COG: COG0514
YP_405052.1	Code: GE; COG: COG2610
YP_405053.2	thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate
YP_405054.1	regulator of gnt operon; Code: K; COG: COG1609
YP_405055.1	Code: R; COG: COG1741
YP_405056.1	Code: R; COG: COG0673
YP_405059.1	periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides
YP_405061.1	with UgpABC is involved in uptake of glycerol-3-phosphate
YP_405062.1	with UgpEC is involved in the uptake of glycerol-3-phosphate
YP_405063.1	with UgpACE is involved in the uptake of glycerol-3-phosphate
YP_405064.1	Code: S; COG: COG4700
YP_405065.2	''with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''
YP_405066.1	''Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''
YP_405067.1	''Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine''
YP_405068.1	Code: E; COG: COG0559
YP_405069.1	Code: E; COG: COG0683
YP_405070.1	Code: L; COG: COG1662
YP_405071.1	Code: L; COG: COG3677
YP_405073.1	Code: E; COG: COG0683
YP_405074.1	regulation of proteins induced at high temperatures; binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_405075.1	''ABC transporter, membrane protein''
YP_405076.1	''ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions''
YP_405077.1	signal recognition protein receptor; functions in the targeting and insertion of membrane proteins
YP_405078.1	catalyzes the methylation of 16S rRNA at position G966
YP_405079.1	Code: S; COG: COG3776
YP_405081.1	''P-type ATPase involved in the export of lead, cadmium, zinc and mercury''
YP_405082.1	TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs
YP_405083.1	Code: S; COG: COG1738
YP_405086.1	Code: L; COG: COG1662
YP_405087.1	Code: L; COG: COG1662
YP_405088.1	Code: L; COG: COG3677
YP_405089.1	''FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP''
YP_405090.1	Code: H; COG: COG2091
YP_405091.1	Code: E; COG: COG0747
YP_405092.1	with NikACDE is involved in nickel transport into the cell
YP_405093.1	with NikABDE is involved in nickel transport into the cell
YP_405094.1	with NikABCE is involved in nickel transport into the cell
YP_405095.1	with NikABCD is involved with nickel transport into the cell
YP_405096.1	Inhibits transcription at high concentrations of nickel
YP_405098.2	Code: L; COG: COG1662
YP_405100.1	Code: GT; COG: COG1762
YP_405101.1	Code: G; COG: COG3414
YP_405103.1	Code: L; COG: COG3677
YP_405104.1	Code: L; COG: COG1662
YP_405108.1	in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane
YP_405109.1	belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine
YP_405110.1	protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity
YP_405111.1	''represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism''
YP_405112.1	''catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester''
YP_405113.1	Code: KR; COG: COG0454
YP_405114.1	Code: S; COG: COG4453
YP_405115.1	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides
YP_405116.1	Code: G; COG: COG0058
YP_405117.1	amylomaltase; amylomaltase; acts to release glucose from maltodextrins
YP_405118.1	Code: GE; COG: COG2610
YP_405119.1	cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_405120.1	Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis
YP_405121.1	Code: S; COG: COG5464
YP_405123.1	cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake
YP_405124.1	Code: P; COG: COG1918
YP_405125.1	Code: K; COG: COG2183
YP_405126.1	''necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus''
YP_405127.1	sensor, EnvZ; outer membrane protein synthesis; part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation
YP_405128.1	modulates expression of ompF and ompC; membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR
YP_405129.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_405133.2	''becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers''
YP_405134.1	Code: J; COG: COG1188
YP_405135.1	Code: R; COG: COG1011
YP_405137.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_405138.2	penicillin-binding protein 1A; bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits
YP_405141.1	Code: NU; COG: COG3166
YP_405144.1	type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_405145.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_405146.1	interferes with cell division; Code: S; COG: COG3266
YP_405147.1	Code: L; COG: COG0338
YP_405148.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_405149.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_405150.1	''catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA''
YP_405152.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_405153.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405154.1	Code: G; COG: COG1015
YP_405155.1	phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE)
YP_405156.1	Code: L; COG: COG1662
YP_405157.1	Code: K; COG: COG2207
YP_405158.1	Code: C; COG: COG1142
YP_405159.1	transaminase C; ''transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis''
YP_405160.1	Code: R; COG: COG2992
YP_405161.1	Code: K; COG: COG1609
YP_405167.1	AICAR formyltransferase; IMP cyclohydrolase; involved in de novo purine biosynthesis
YP_405168.1	GAR synthetase; catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_405169.1	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein
YP_405170.1	Code: T; COG: COG0642
YP_405171.2	Code: UNTP; COG: COG3678
YP_405173.1	HU-2; histone-like DNA-binding protein
YP_405174.1	Code: S; COG: COG3068
YP_405175.1	deoxyinosine 3'endoduclease; ''Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures''
YP_405176.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_405177.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_405178.1	binds specifically to the major sigma factor sigma 70; active in stationary phase
YP_405179.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_405180.1	catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_405181.2	Code: H; COG: COG0476
YP_405182.1	''with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate''
YP_405183.2	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_405184.1	''in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center''
YP_405185.1	Code: L; COG: COG1662
YP_405186.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_405187.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_405188.1	''present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors''
YP_405189.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_405190.1	regulates synthesis of L1 and L11; ''in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA''
YP_405191.1	binds directly to 23S ribosomal RNA
YP_405192.1	Modulates Rho-dependent transcription termination
YP_405193.1	''forms a complex with SecY and SecG; SecYEG forms a  protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force''
YP_405194.1	''EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu''
YP_405196.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_405197.1	''catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon''
YP_405198.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_405199.2	required for biosynthesis of D-glutamate and peptidoglycan; ''converts L-glutamate to D-glutamate, a component of peptidoglycan''
YP_405200.1	involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space
YP_405201.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_405203.1	''negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis''
YP_405205.1	Code: L; COG: COG1662
YP_405209.1	member of the NlpC/P60 superfamily of peptidases
YP_405210.1	when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_405211.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_405212.1	multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_405213.1	''MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor''
YP_405214.1	Code: GER; COG: COG0697
YP_405215.1	Code: S; COG: COG3738
YP_405216.2	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_405217.1	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_405218.1	Code: G; COG: COG1080
YP_405220.1	''FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site''
YP_405221.1	''FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS''
YP_405222.1	involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein
YP_405223.1	Code: O; COG: COG1180
YP_405224.1	''FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog''
YP_405225.1	Code: K; COG: COG2207
YP_405226.1	Code: R; COG: COG2194
YP_405227.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_405228.1	catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis
YP_405229.1	''catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate''
YP_405230.2	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_405231.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_405232.1	activator of hydrogen peroxide-inducible genes; ''Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA''
YP_405233.2	catalyzes the conversion of NADPH to NADH
YP_405235.1	Code: L; COG: COG1662
YP_405236.1	Code: M; COG: COG3209
YP_405237.1	''RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome''
YP_405238.1	factor Y; helicase; ''binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity''
YP_405239.1	''negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins''
YP_405240.1	Code: D; COG: COG3087
YP_405241.1	heat shock protein involved in degradation of misfolded proteins
YP_405242.1	heat shock protein involved in degradation of misfolded proteins
YP_405243.1	1,4-dihydroxy-2-naphthoate --> dimethylmenaquinone; ''catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate''
YP_405244.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_405245.1	Code: L; COG: COG1662
YP_405247.1	Code: L; COG: COG3677
YP_405248.1	Code: L; COG: COG1662
YP_405249.1	Code: L; COG: COG2963
YP_405252.1	Code: S; COG: COG3074
YP_405253.1	Code: G; COG: COG0580
YP_405254.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_405255.1	unknown function in glycerol metabolism; ''type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese''
YP_405256.1	Code: C; COG: COG1018
YP_405257.1	with UspC and Usp E is involved in resistance to UV radiation
YP_405258.1	Code: S; COG: COG3691
YP_405259.1	Code: L; COG: COG1662
YP_405260.1	Code: S; COG: COG3152
YP_405262.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_405263.1	Code: L; COG: COG1662
YP_405264.1	Code: L; COG: COG3677
YP_405265.1	Code: P; COG: COG1613
YP_405266.1	''catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis''
YP_405267.1	''member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers''
YP_405268.2	repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates
YP_405269.1	response regulator in two-component regulatory system with CpxA; part of the envelope stress response system
YP_405270.1	probable sensor protein; acting on arcA; part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
YP_405271.2	Code: S; COG: COG2258
YP_405272.2	transports degraded pectin products into the bacterial cell
YP_405273.1	SodA; manganese binding; only present under aerobic conditions; destroys free radicals
YP_405274.1	transports L-rhamnose and L-lyxose into the cell
YP_405275.1	activates the expression of rhaRS in response to L-rhamnose
YP_405276.1	activates the expression of the rhaBAD operon and rhaT gene
YP_405277.1	Code: G; COG: COG1070
YP_405278.1	Code: G; COG: COG0235
YP_405279.1	Code: S; COG: COG3254
YP_405281.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_405282.1	Code: C; COG: COG0243
YP_405283.1	Code: C; COG: COG0437
YP_405284.1	cytochrome b556(FDO) component; heme containing
YP_405285.1	required for the formation of active formate dehydrogenase
YP_405286.1	Code: L; COG: COG1662
YP_405287.1	Code: L; COG: COG3677
YP_405288.1	Code: KR; COG: COG0454
YP_405289.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_405290.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_405291.2	Code: R; COG: COG1011
YP_405295.1	Code: L; COG: COG2963
YP_405300.1	Code: GEPR; COG: COG0477
YP_405301.1	Code: L; COG: COG3677
YP_405302.1	Code: L; COG: COG1662
YP_405303.1	Code: L; COG: COG3385
YP_405304.1	Code: T; COG: COG1217
YP_405305.1	forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme
YP_405306.1	nitrogen regulator II, NRII; sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation
YP_405307.1	sensor glnL; nitrogen regulator I, NRI; response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54
YP_405308.2	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_405309.1	Code: S; COG: COG3078
YP_405310.2	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_405311.1	DNA polymerase I, 3' --> 5' polymerase, 5' --> 3' and 3' --> 5' exonuclease; ''has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair''
YP_405312.1	Code: I; COG: COG0204
YP_405314.1	Code: L; COG: COG1662
YP_405315.1	Code: L; COG: COG3677
YP_405316.1	essential for cytochrome c synthesis and formate-dependent reduction; Code: OC; COG: COG0526
YP_405317.1	catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages
YP_405318.1	Code: S; COG: COG3084
YP_405319.1	molybdopterin ---> molybdopterin-guanine dinucleotide, protein Ar; Links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis
YP_405320.1	Code: H; COG: COG1763
YP_405321.1	catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX
YP_405322.1	requires TrkE; Code: P; COG: COG0168
YP_405323.1	Code: S; COG: COG1739
YP_405324.1	catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters
YP_405325.1	4-enzyme protein; ''includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids''
YP_405326.1	3-ketoacyl-CoA thiolase; acetyl-CoA transferase; FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_405327.1	flavin reductase; NADPH:flavin oxidoreductase; NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin
YP_405328.1	catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol
YP_405329.1	Code: K; COG: COG0250
YP_405330.1	with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane
YP_405331.2	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_405332.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_405333.1	an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions
YP_405334.1	Code: S; COG: COG3165
YP_405335.1	2-octaprenyl-6-methoxy-1,4-benzoquinone --> 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone; Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_405336.1	YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner
YP_405337.1	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_405338.1	Code: Q; COG: COG0412
YP_405339.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_405340.1	Code: K; COG: COG0583
YP_405341.1	Code: GER; COG: COG0697
YP_405342.1	''purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium''
YP_405343.1	lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates
YP_405344.2	Code: E; COG: COG1280
YP_405345.2	Code: E; COG: COG1280
YP_405346.1	''functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway''
YP_405347.1	catalyzes the hydrolysis of phosphatidylcholine
YP_405348.2	Code: Q; COG: COG2050
YP_405349.1	Code: R; COG: COG2962
YP_405350.1	Code: L; COG: COG3677
YP_405351.1	Code: L; COG: COG1662
YP_405352.1	Code: L; COG: COG1662
YP_405353.1	Code: L; COG: COG3677
YP_405354.1	responsible for the influx of magnesium ions
YP_405355.1	Code: S; COG: COG3698
YP_405356.1	Code: S; COG: COG1912
YP_405357.1	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_405358.1	YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function
YP_405359.1	acts on cer sequence of ColE1; effects chromosome segregation at cell division; site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_405360.1	Code: S; COG: COG3159
YP_405361.2	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_405362.1	Code: N; COG: COG5567
YP_405364.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_405365.1	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_405366.1	hydroxymethylbilane synthase; transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_405367.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_405368.1	Code: H; COG: COG2959
YP_405369.1	Code: H; COG: COG3071
YP_405370.1	Code: P; COG: COG3119
YP_405371.1	Code: L; COG: COG1662
YP_405372.1	uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function
YP_405373.1	synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG1922
YP_405374.1	synthesis of enterobacterial common antigen (ECA); enterobacterial common antigen polymerase
YP_405375.1	catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis
YP_405376.1	Code: R; COG: COG2244
YP_405377.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_405378.1	Code: KR; COG: COG0454
YP_405379.1	Code: M; COG: COG1209
YP_405380.1	synthesis of enterobacterial common antigen (ECA); catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid
YP_405381.1	synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0381
YP_405382.1	Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein
YP_405383.1	synthesis of enterobacterial common antigen (ECA); Code: M; COG: COG0472
YP_405385.1	polarity suppressor; An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_405387.1	Code: OC; COG: COG0526
YP_405388.1	''enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation''
YP_405389.1	exopolyphosphatase; ''catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation''
YP_405390.1	a single-stranded DNA dependent ATPase; single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication
YP_405391.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405392.1	rotamase C; Code: O; COG: COG0760
YP_405393.1	''catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis''
YP_405394.2	participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_405395.1	dehydratase; ''threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway''
YP_405396.1	''catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis''
YP_405397.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_405398.1	Code: S; COG: COG3978
YP_405399.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_405401.1	Code: L; COG: COG3547
YP_405402.1	Code: S; COG: COG3085
YP_405403.1	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
YP_405404.1	Code: K; COG: COG2186
YP_405405.1	Code: GEPR; COG: COG0477
YP_405406.1	DNA-binding transcriptional repressor of ribose metabolism
YP_405407.1	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_405408.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_405409.1	Code: L; COG: COG1662
YP_405410.1	Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH
YP_405411.2	''interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase''
YP_405412.1	contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA
YP_405413.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_405414.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_405415.1	''An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group''
YP_405416.1	possibly involved in chromosome replication; GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_405417.1	possibly involved in chromosome replication; glucose-inhibited division; glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_405418.2	dispensable protein; affects expression of atpB; Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_405419.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_405420.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_405421.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_405422.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_405423.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_405424.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_405425.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_405426.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_405427.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_405428.1	''Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source''
YP_405431.1	periplasmic phosphate-binding protein; Code: P; COG: COG0226
YP_405432.1	part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_405433.1	Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_405434.1	Code: P; COG: COG1117
YP_405435.1	enzyme in phosphate metabolism; regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon
YP_405438.1	Code: L; COG: COG3677
YP_405439.1	Code: L; COG: COG1662
YP_405443.1	Code: UW; COG: COG5295
YP_405445.1	Code: C; COG: COG1620
YP_405446.1	represses the lctPRD operon
YP_405447.1	flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration
YP_405448.1	member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates
YP_405449.1	catalyzes the O-acetylation of serine
YP_405450.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_405451.1	protein export; molecular chaperone; may bind to signel sequence; molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_405452.1	Code: O; COG: COG0695
YP_405453.1	Code: P; COG: COG0607
YP_405454.1	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_405455.1	Code: D; COG: COG4942
YP_405456.1	Code: S; COG: COG2861
YP_405457.1	Code: M; COG: COG0463
YP_405458.1	''converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism''
YP_405459.1	glycine acetyltransferase; catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine
YP_405460.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_405461.1	lipopolysaccharide core biosynthesis; catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core
YP_405462.1	lipopolysaccharide core biosynthesis; Code: M; COG: COG0859
YP_405464.1	Code: M; COG: COG3306
YP_405465.1	Code: M; COG: COG1442
YP_405467.1	Code: M; COG: COG1442
YP_405468.1	Code: M; COG: COG1442
YP_405470.1	lipopolysaccharide core biosynthesis; Code: M; COG: COG0438
YP_405471.1	Code: M; COG: COG0859
YP_405472.1	KDO transferase; catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_405473.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_405474.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_405475.1	''in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif''
YP_405476.1	required for 70S ribosome assembly
YP_405477.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_405478.2	flavoprotein affecting synthesis of DNA and pantothenate metabolism; ''catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine''
YP_405479.1	catalyzes the formation of dUMP from dUTP
YP_405480.2	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_405482.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_405483.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_405484.1	Code: S; COG: COG1561
YP_405486.1	Code: S; COG: COG2860
YP_405488.1	''Essential for recycling GMP and indirectly, cGMP''
YP_405489.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_405490.1	also guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Code: TK; COG: COG0317
YP_405491.1	specifically modifies tRNA at position G18
YP_405492.1	resolution of Holliday junctions; branch migration; catalyzes branch migration in Holliday junction intermediates
YP_405493.1	Code: E; COG: COG0786
YP_405494.1	Code: F; COG: COG2233
YP_405496.1	Code: L; COG: COG2963
YP_405498.1	Code: G; COG: COG1486
YP_405499.1	Code: E; COG: COG1982
YP_405500.1	Code: L; COG: COG3677
YP_405501.1	Code: L; COG: COG1662
YP_405502.1	Code: K; COG: COG2207
YP_405503.1	Code: E; COG: COG0531
YP_405504.1	with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division
YP_405505.1	Code: T; COG: COG0642
YP_405506.1	low-affinity transport system; Code: GEPR; COG: COG0477
YP_405508.1	Code: L; COG: COG3677
YP_405509.1	Code: L; COG: COG1662
YP_405510.1	Code: L; COG: COG1662
YP_405511.1	Code: L; COG: COG3677
YP_405512.1	Code: P; COG: COG2824
YP_405513.1	Code: P; COG: COG3638
YP_405514.1	Code: P; COG: COG3221
YP_405515.1	Code: P; COG: COG3639
YP_405516.1	may be involved in phosphonate uptake and biodegradation
YP_405517.1	Code: P; COG: COG3625
YP_405518.1	Code: P; COG: COG3626
YP_405519.1	Code: P; COG: COG3627
YP_405520.1	Code: P; COG: COG4107
YP_405521.1	Code: P; COG: COG4778
YP_405522.1	Code: P; COG: COG3454
YP_405523.1	Code: P; COG: COG3709
YP_405524.1	PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role
YP_405525.1	required for the use of phosphonates and phosphite as phosphorus sources
YP_405528.1	Code: T; COG: COG0642
YP_405529.1	Code: G; COG: COG1129
YP_405531.1	Code: G; COG: COG1879
YP_405532.1	Code: R; COG: COG3822
YP_405533.1	Code: G; COG: COG0191
YP_405534.1	Code: G; COG: COG0524
YP_405535.1	Code: TK; COG: COG0745
YP_405536.1	Code: L; COG: COG1662
YP_405540.1	Code: L; COG: COG3677
YP_405541.1	Code: L; COG: COG1662
YP_405542.2	Code: G; COG: COG2814
YP_405543.1	Code: S; COG: COG4737
YP_405544.1	Code: K; COG: COG2944
YP_405546.1	catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type
YP_405547.1	cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate
YP_405548.1	membrane protein regulates uhpT expression
YP_405549.1	Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph
YP_405550.1	sensor, uhpB; ''response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter''
YP_405551.1	Code: L; COG: COG1662
YP_405552.1	Code: L; COG: COG1662
YP_405554.1	''with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit''
YP_405555.1	Code: EH; COG: COG0028
YP_405557.1	multidrug resistance; multidrug efflux protein involved in adaptation to low energy shock
YP_405558.1	Code: R; COG: COG0641
YP_405560.1	Code: S; COG: COG2149
YP_405562.1	Code: P; COG: COG3119
YP_405563.1	Code: L; COG: COG1662
YP_405564.1	Code: L; COG: COG3677
YP_405565.1	Code: L; COG: COG1662
YP_405566.1	Code: G; COG: COG1486
YP_405567.1	Code: K; COG: COG2188
YP_405568.2	Code: R; COG: COG2985
YP_405569.2	''16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent''
YP_405570.1	with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress
YP_405571.2	Code: R; COG: COG5645
YP_405573.2	FAD/NAD(P)-binding domain
YP_405575.1	''YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins''
YP_405576.1	Code: S; COG: COG3753
YP_405577.1	type II topoisomerase; ATPase activity; negatively supercoils closed circular double-stranded DNA
YP_405578.1	''Required for DNA replication; binds preferentially to single-stranded, linear DNA''
YP_405579.1	binds the polymerase to DNA and acts as a sliding clamp
YP_405580.1	DNA biosynthesis; initiation of chromosome replication; can be transcription regulator; binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself
YP_405581.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_405582.1	protein C5; processes tRNA, 4.5S RNA; protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_405583.1	Code: S; COG: COG0759
YP_405584.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_405585.1	thiophene and furan oxidation; ''in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE''
YP_405586.1	Code: L; COG: COG1662
YP_405588.1	Code: L; COG: COG1662
YP_405589.1	Code: L; COG: COG3677
YP_405591.1	Code: L; COG: COG2963
YP_405592.1	Code: L; COG: COG3677
YP_405593.1	Code: L; COG: COG1662
YP_405594.1	''YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily''
YP_405595.1	Code: R; COG: COG2252
YP_405596.1	Code: H; COG: COG2091
YP_405597.1	Involved in anaerobic NO protection
YP_405598.1	Confers resistance to chloramphenicol
YP_405599.1	Code: E; COG: COG0814
YP_405600.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405601.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_405604.1	Code: L; COG: COG1662
YP_405605.1	Code: M; COG: COG3209
YP_405606.1	Code: O; COG: COG0625
YP_405607.1	L-seryl-tRNA (Ser) selenium transferase; catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_405608.1	Code: J; COG: COG3276
YP_405610.1	Code: L; COG: COG3677
YP_405611.1	Code: L; COG: COG1662
YP_405612.1	Code: S; COG: COG3223
YP_405616.1	Code: L; COG: COG1662
YP_405619.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_405620.1	lysine sensitive; catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive
YP_405621.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405622.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_405623.1	fumarate hydratase Class I; anaerobic isozyme; Code: C; COG: COG1951
YP_405624.1	''functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters''
YP_405625.1	Code: L; COG: COG1662
YP_405626.1	Code: L; COG: COG3677
YP_405627.1	Code: L; COG: COG1662
YP_405629.1	response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration
YP_405630.1	C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration
YP_405631.1	Code: S; COG: COG3592
YP_405632.1	Code: R; COG: COG2388
YP_405633.1	Code: L; COG: COG1662
YP_405634.1	Code: L; COG: COG1662
YP_405635.1	Code: L; COG: COG1662
YP_405637.1	Code: L; COG: COG3677
YP_405638.1	Code: L; COG: COG1662
YP_405639.1	Code: G; COG: COG1129
YP_405640.1	Code: G; COG: COG1172
YP_405641.1	membrane component of a  sugar ABC transporter system
YP_405642.1	''catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate''
YP_405643.1	Code: M; COG: COG0773
YP_405644.1	Code: S; COG: COG3028
YP_405645.1	maturation of antibiotic MccB17, see tld genes; protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
YP_405647.1	Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor
YP_405648.1	activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions
YP_405649.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_405650.1	Code: G; COG: COG0366
YP_405651.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_405652.1	regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon
YP_405653.1	P-type ATPase involved in magnesium influx
YP_405654.1	Code: J; COG: COG0251
YP_405655.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_405656.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_405658.1	Code: J; COG: COG0251
YP_405659.1	Code: IQR; COG: COG1028
YP_405662.1	Code: G; COG: COG2731
YP_405664.1	Code: L; COG: COG3677
YP_405665.1	Code: L; COG: COG1662
YP_405666.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_405667.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405668.1	''catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.''
YP_405669.1	Code: S; COG: COG3076
YP_405670.2	Code: KR; COG: COG0454
YP_405671.1	Code: L; COG: COG1662
YP_405672.1	Code: L; COG: COG1662
YP_405673.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_405674.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_405675.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_405676.1	Code: R; COG: COG0795
YP_405677.1	Code: R; COG: COG0795
YP_405678.1	Code: R; COG: COG0433
YP_405679.1	Code: R; COG: COG1064
YP_405681.1	Code: L; COG: COG2963
YP_405682.1	Part of the FecBCDE citrate-dependent iron (III) transport system
YP_405683.1	''Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.''
YP_405684.1	part of the FecBCDE citrate-dependent iron (III) transport system
YP_405685.1	Code: P; COG: COG4772
YP_405686.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport
YP_405688.1	Code: L; COG: COG1662
YP_405689.1	Code: L; COG: COG3677
YP_405694.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405695.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_405697.1	catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA
YP_405698.1	Code: K; COG: COG2390
YP_405701.1	Code: G; COG: COG3715
YP_405703.1	Code: ER; COG: COG1063
YP_405704.1	Code: P; COG: COG1283
YP_405705.1	Code: L; COG: COG1662
YP_405706.1	Code: L; COG: COG3677
YP_405707.1	repressor of metE and metF; one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity
YP_405708.2	''regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase''
YP_405709.1	Code: L; COG: COG1662
YP_405711.1	catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol
YP_405712.1	Code: C; COG: COG2224
YP_405713.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_405714.1	Code: L; COG: COG1662
YP_405715.1	Code: L; COG: COG3677
YP_405716.1	Code: KR; COG: COG0454
YP_405718.1	Code: L; COG: COG3385
YP_405719.1	Code: L; COG: COG1662
YP_405720.1	Code: L; COG: COG3677
YP_405721.1	Code: L; COG: COG1662
YP_405722.1	Code: S; COG: COG3274
YP_405723.1	Code: L; COG: COG2963
YP_405724.1	Code: L; COG: COG2801
YP_405726.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_405727.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_405729.1	transcriptional activator of hns; Code: K; COG: COG1278
YP_405730.1	Code: K; COG: COG2944
YP_405732.2	Code: CHR; COG: COG1052
YP_405733.1	Code: C; COG: COG0243
YP_405734.1	''constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine''
YP_405736.1	Code: L; COG: COG1662
YP_405739.1	YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo
YP_405740.1	negative regulator of ulaG and ulaABCDEF
YP_405742.2	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_405743.1	Code: G; COG: COG3414
YP_405744.1	Code: GT; COG: COG1762
YP_405745.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_405746.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_405747.1	''binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21''
YP_405748.1	binds single-stranded DNA at the primosome assembly site
YP_405749.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_405750.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_405751.1	Code: L; COG: COG1662
YP_405752.1	Code: L; COG: COG3677
YP_405753.1	Code: L; COG: COG1662
YP_405754.1	Code: M; COG: COG3061
YP_405755.2	rotamase; FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_405756.1	''involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine''
YP_405757.1	Involved in anaerobic NO protection and iron metabolism
YP_405758.1	Code: GER; COG: COG0697
YP_405759.1	Code: MG; COG: COG0702
YP_405760.1	Code: K; COG: COG1733
YP_405761.1	''periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate''
YP_405762.1	Code: L; COG: COG1662
YP_405763.1	affects pool of 3'-phosphoadenosine-5'-phosphosulfate in pathway of sulfite synthesis; ''catalyzes the formation of AMP from adenosine-3',5'-bisphosphate''
YP_405764.1	Code: L; COG: COG1662
YP_405765.1	Code: L; COG: COG3677
YP_405766.1	Code: L; COG: COG1662
YP_405767.1	Code: E; COG: COG1509
YP_405768.1	EF-P; Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_405769.1	acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex
YP_405770.2	suppresses groEL, may be chaperone; Code: P; COG: COG2076
YP_405771.1	lipocalin; lipocalin; globomycin-sensitive outer membrane lipoprotein
YP_405772.1	penicillin resistance; Code: V; COG: COG1680
YP_405773.1	membrane anchor polypeptide; in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_405774.1	membrane anchor polypeptide; ''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''
YP_405775.1	''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''
YP_405776.1	''part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB''
YP_405777.2	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_405780.1	Code: S; COG: COG5463
YP_405781.1	Code: E; COG: COG0754
YP_405782.1	catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA
YP_405784.1	Code: L; COG: COG1662
YP_405785.1	Code: L; COG: COG3677
YP_405786.1	Code: L; COG: COG1662
YP_405787.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_405788.2	''3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs''
YP_405789.1	negatively regulates the transcription of genes upregulated by nitrosative stress
YP_405790.1	''catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis''
YP_405791.1	Code: S; COG: COG3242
YP_405792.1	with HflK inhibits proteolysis of lambda cII protein by FtsH
YP_405793.1	with HflC inhibits proteolysis of lambda cII protein by FtsH
YP_405794.1	involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein
YP_405795.1	a growth-related protein; Stimulates the elongation of poly(A) tails
YP_405796.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_405797.1	enzyme in methyl-directed mismatch repair; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_405798.1	a murein hydrolase; Code: M; COG: COG0860
YP_405799.1	possibly involved in cell wall synthesis
YP_405800.1	Code: L; COG: COG1662
YP_405802.1	Code: L; COG: COG1662
YP_405803.1	Code: C; COG: COG1600
YP_405804.2	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_405805.2	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_405806.1	phospholipid synthesis; catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_405807.1	Code: M; COG: COG3264
YP_405808.1	Code: E; COG: COG0531
YP_405809.1	Code: L; COG: COG1662
YP_405811.1	Code: L; COG: COG1662
YP_405812.1	Code: L; COG: COG3677
YP_405814.1	copper tolerance; two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_405815.1	cytochrome c biogenesis; copper binding protein required for copper tolerance; involved in resistance toward heavy metals
YP_405816.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_405817.1	aspartase; catalyzes the formation of fumarate from aspartate
YP_405818.1	Protein affecting phage T7 exclusion by the F plasmid; F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_405819.1	Code: L; COG: COG1662
YP_405820.1	uncharacterized member of the APC superfamily of amino acid transporters; unknown function
YP_405821.1	10 kDa chaperone binds to Hsp60 in pres. Mg-ATP, suppressing its ATPase activity; 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_405822.1	chaperone Hsp60, peptide-dependent ATPase, heat shock protein; ''60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth''
YP_405824.1	Code: L; COG: COG1662
YP_405825.1	Code: R; COG: COG3054
YP_405827.1	Code: R; COG: COG1253
YP_405828.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_405829.1	Code: M; COG: COG0729
YP_405830.1	Code: S; COG: COG2911
YP_405831.1	Code: S; COG: COG2105
YP_405832.1	part of the toxin-antitoxin ChpB-ChpS system
YP_405833.1	toxin of the ChpB-ChpS toxin-antitoxin system
YP_405834.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_405835.1	Code: L; COG: COG1662
YP_405836.1	Code: E; COG: COG3104
YP_405837.1	Code: L; COG: COG2801
YP_405838.1	Code: L; COG: COG2801
YP_405840.1	Code: L; COG: COG1662
YP_405841.1	Code: L; COG: COG3328
YP_405843.1	Code: L; COG: COG1662
YP_405844.1	sensor EvgS; ''response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance''
YP_405845.1	Code: ET; COG: COG0834
YP_405846.1	Code: L; COG: COG3436
YP_405847.1	Code: L; COG: COG3436
YP_405848.1	Code: L; COG: COG3436
YP_405850.1	Code: L; COG: COG3677
YP_405851.1	Code: L; COG: COG1662
YP_405852.1	Code: L; COG: COG2801
YP_405854.1	Code: L; COG: COG1662
YP_405856.1	Code: L; COG: COG1662
YP_405857.1	Code: L; COG: COG2801
YP_405858.1	Code: L; COG: COG2963
YP_405862.1	Code: L; COG: COG2963
YP_405863.1	Code: L; COG: COG1662
YP_405864.1	Code: GER; COG: COG0697
YP_405865.1	Code: P; COG: COG1464
YP_405866.1	Code: L; COG: COG1662
YP_405867.1	Code: L; COG: COG3677
YP_405868.1	Code: P; COG: COG0025
YP_405869.1	Code: R; COG: COG2252
YP_405870.1	Code: K; COG: COG0789
YP_405871.1	regulates genes involved in response to oxidative stress
YP_405872.1	Code: L; COG: COG1662
YP_405874.1	binds to single stranded DNA and PriA helcase facilitate replication restart
YP_405875.1	''The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate''
YP_405876.1	Code: S; COG: COG2315
YP_405877.1	Code: S; COG: COG0432
YP_405878.1	Code: L; COG: COG1662
YP_405879.1	Code: L; COG: COG3677
YP_405885.1	tyrosine repressible; catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_405886.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_405887.1	part of primosome; unwinds double stranded DNA
YP_405888.1	Code: CR; COG: COG0604
YP_405889.2	coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia
YP_405890.1	Code: J; COG: COG0042
YP_405893.2	''Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB''
YP_405894.1	unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential
YP_405895.2	Code: V; COG: COG0534
YP_405896.1	regulator for lexA regulon; Represses a number of genes involved in the response to DNA damage
YP_405897.1	Code: M; COG: COG0818
YP_405898.2	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_405899.1	''catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway''
YP_405900.2	catalyzes the formation of 4-hydroxybenzoate from chorismate
YP_405901.1	Code: L; COG: COG3677
YP_405902.1	Code: L; COG: COG1662
YP_405903.1	Code: L; COG: COG1662
YP_405904.1	Code: K; COG: COG0583
YP_405905.1	Code: S; COG: COG1295
YP_405906.1	Code: GEPR; COG: COG0477
YP_405907.1	Code: M; COG: COG2982
YP_405908.1	in Escherichia coli this protein is involved in flagellar function
YP_405909.1	Code: R; COG: COG0612
YP_405910.1	involved in the transport of C4-dicarboxylates across the membrane
YP_405911.1	HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a  phosphodiesterase from E. coli
YP_405912.1	''binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)''
YP_405913.2	''polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis''
YP_405915.1	Code: L; COG: COG1662
YP_405916.1	Code: L; COG: COG3677
YP_405917.1	Code: L; COG: COG1662
YP_405919.1	Code: E; COG: COG0814
YP_405920.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_405921.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_405922.1	Code: EP; COG: COG1173
YP_405923.1	transports peptides consisting of two or three amino acids
YP_405924.1	Code: E; COG: COG0747
YP_405926.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405927.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_405929.1	Code: L; COG: COG2801
YP_405930.1	Code: L; COG: COG1662
YP_405933.1	Code: L; COG: COG3677
YP_405934.1	Code: L; COG: COG1662
YP_405936.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_405937.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_405938.1	Code: L; COG: COG2801
YP_405941.1	Code: L; COG: COG2003
YP_405947.1	activator of (R)-hydroxyglutaryl-CoA dehydratase
YP_405948.1	Code: GEPR; COG: COG0477
YP_405949.1	Code: S; COG: COG5464
YP_405950.1	Code: KE; COG: COG1167
YP_405951.1	Code: S; COG: COG5457
YP_405953.1	Code: L; COG: COG1662
YP_405954.1	Code: R; COG: COG0523
YP_405955.1	Code: S; COG: COG2879
YP_405956.1	Code: T; COG: COG1966
YP_405957.1	Code: L; COG: COG2963
YP_405959.2	catalyzes the transfer of phosphoglycerol to the glucan backbone
YP_405961.1	initiation and chain elongation; acts to load the DnaB helicase onto the initiation site during DNA replication
YP_405962.1	primosomal protein i; ''This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'''
YP_405963.2	Code: S; COG: COG3610
YP_405964.1	Code: L; COG: COG3677
YP_405965.1	Code: L; COG: COG1662
YP_405966.1	Code: L; COG: COG1662
YP_405967.1	Code: L; COG: COG1662
YP_405968.1	Code: R; COG: COG4114
YP_405970.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_405971.1	with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_405972.1	acetylation of N-terminal alanine; alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_405973.1	''manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily''
YP_405974.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_405975.1	Code: L; COG: COG1662
YP_405976.1	Code: R; COG: COG2823
YP_405977.1	Code: R; COG: COG4667
YP_405978.1	Code: L; COG: COG0084
YP_405979.1	Code: O; COG: COG1180
YP_405981.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_405982.1	''Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate''
YP_405983.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_405984.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_405985.1	Code: L; COG: COG1662
YP_405986.1	Code: K; COG: COG1396
YP_405987.1	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins
YP_405988.1	Code: R; COG: COG3726
YP_405989.1	catalyzes the formation of serine from O-phosphoserine
YP_405990.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_405991.2	catalyzes the formation of NAD(+) from nicotinamide ribonucleotide
YP_405992.1	''ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence''
YP_405993.2	catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan
YP_405994.1	trp aporepressor; When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_405995.2	pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog
YP_405996.1	catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate
YP_405997.1	Code: K; COG: COG2207
YP_405998.1	Code: S; COG: COG3045
YP_405999.1	response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation
YP_406000.1	sensors, ArcB and CpxA; Code: TK; COG: COG0745
YP_406002.1	member of the SPOUT superfamily of methyltransferases
YP_406005.1	protein secreted by the Mxi-Spa secretion machinery
YP_406006.1	periplasmic phosphatase, apyrase, ATP diphosphohydrolase
YP_406011.1	probably secreted by the Mxi-Spa secretion machinery
YP_406012.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_406013.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_406014.1	secreted by the Mxi-Spa secretion machinery
YP_406024.1	secreted by the Mxi-Spa secretion machinery
YP_406026.1	probably secreted by the Mxi-Spa secretion machinery
YP_406038.1	probably secreted by the Mxi-Spa machinery
YP_406039.1	probably secreted by the Mxi-Spa machinery
YP_406046.1	secreted by the Mxi-Spa secretion machinery
YP_406047.1	secreted by the Mxi-Spa secretion machinery
YP_406056.1	secreted by the Mxi-Spa secretion machinery
YP_406057.1	SenA; probably secreted by the Mxi-Spa secretion machinery
YP_406065.1	probable periplasmic UDP-sugar hydrolase; catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides
YP_406068.1	periplasmic non specific acid ohosphatase
YP_406071.1	probably secreted by the Mxi-Spa secretion machinery
YP_406098.1	controlled cell death protein; post-segregation toxin; toxin addiction system
YP_406100.1	secreted by the Mxi-Spa secretion machinery
YP_406102.1	secreted by the Mxi-Spa secretion machinery
YP_406110.1	required for proper localization of IcsA (VirG) at the surface of bacteria
YP_406111.1	probable lipid A transacetylase; Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_406123.1	cleaves origin of transfer and unwinds; oriT relaxase
YP_406126.1	putative fertility inhibition protein
YP_406138.1	RepA
YP_406152.1	probably secreted by the Mxi-Spa secretion machinery
YP_406161.1	invasion plasmid antigen
YP_406162.1	transcriptional activator required for tanscription of the ipa, mxi, and spa operons
YP_406163.1	putative acyl carrier protein
YP_406164.1	secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells
YP_406165.1	secreted by the Mxi-Spa machinery, required for entry of bacteria into epithelial cells
YP_406166.1	secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells
YP_406167.1	secreted by the Mxi-Spa secretion machinery, required for entry into epithelial cells
YP_406168.1	cytoplasmic chaperone for IpaB and IpaC
YP_406169.1	secreted by the Mxi-Spa machinery
YP_406170.1	similar to IpgE, putative chaperone
YP_406171.1	invasion protein
YP_406172.1	secreted by the Mxi-Spa machinery, modulates entry of bacteria into epithelial cells
YP_406173.1	cytoplasmic chaperone for IpgD
YP_406174.1	periplasmic protein, similar to the catalytic site of lyzozymes
YP_406175.1	component of the Mxi-Spa secretion machinery, contains one transmembrane segment
YP_406176.1	component of the Mxi-Spa secretion machinery
YP_406177.1	component of the Mxi-Spa secretion machinery
YP_406178.1	lipoprotein, component of the Mxi-Spa secretion machinery
YP_406179.1	putative component of the Mxi-Spa secretion machinery
YP_406180.1	putative component of the Mxi-Spa secretion machinery
YP_406181.1	secreted by and putative component of the Mxi-Spa secretion machinery
YP_406182.1	lipoprotein, component of the Mxi-Spa secretion machinery
YP_406183.1	similar to transcriptional activators of the AraC family
YP_406184.1	outermembrane protein of the secretin family, component of the Mxi-Spa secretion machinery
YP_406185.1	secreted by and putative component of the Mxi-Spa secretion machinery, similar to YopN (secreted by the type III secretion machinery of Yersinia enterocoltica)
YP_406186.1	innermembrane protein, component of the Mxi-Spa secretion machinery
YP_406187.1	putative component of the Mxi-Spa secretion machinery
YP_406188.1	component of the Mxi-Spa secretion machinery, putative ATPase; Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase
YP_406189.1	component of the Mxi-Spa secretion machinery
YP_406190.1	secreted by and component of the Mxi-Spa machinery
YP_406191.1	component of the Mxi-Spa secretion machinery
YP_406192.1	component of the Mxi-Spa secretion machinery; part of a type III secretory system probably involved in invasion into eukaryotic cells
YP_406193.1	component of the Mxi-Spa secretion machinery
YP_406194.1	component of the Mxi-Spa secretion machinery; Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins
YP_406212.1	secreted by the Mxi-Spa secretion machinery
YP_406215.1	VirG; outermembrane protein exposed to the bacterial surface by a C-terminal autotransporter domain and involved in the movement of intracellular bacteria by binding to N-WASP
YP_406216.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_406217.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_406221.1	RepA
YP_406225.2	SopA; outermembrane protease of the OmpP family, involved in cleavage of surface exposed IcsA; outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA
YP_001139944.1	replication initiation protein
YP_001139945.1	IS1 ORF1
YP_001139946.1	IS1 ORF2
YP_001139947.1	glycosyltransferase
YP_001139948.1	glycosyltransferase