-- dump date 20140620_065107 -- class Genbank::misc_feature -- table misc_feature_note -- id note 300267000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 300267000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 300267000003 putative catalytic residues [active] 300267000004 putative nucleotide binding site [chemical binding]; other site 300267000005 putative aspartate binding site [chemical binding]; other site 300267000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 300267000007 dimer interface [polypeptide binding]; other site 300267000008 putative threonine allosteric regulatory site; other site 300267000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 300267000010 putative threonine allosteric regulatory site; other site 300267000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 300267000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 300267000013 homoserine kinase; Region: thrB; TIGR00191 300267000014 Protein of unknown function; Region: YhfT; pfam10797 300267000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 300267000016 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 300267000017 threonine synthase; Validated; Region: PRK09225 300267000018 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 300267000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267000020 catalytic residue [active] 300267000021 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 300267000022 hypothetical protein; Validated; Region: PRK02101 300267000023 transaldolase-like protein; Provisional; Region: PTZ00411 300267000024 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 300267000025 active site 300267000026 dimer interface [polypeptide binding]; other site 300267000027 catalytic residue [active] 300267000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 300267000029 MPT binding site; other site 300267000030 trimer interface [polypeptide binding]; other site 300267000031 hypothetical protein; Provisional; Region: PRK10659 300267000032 hypothetical protein; Provisional; Region: PRK10236 300267000033 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 300267000034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 300267000035 hypothetical protein; Provisional; Region: PRK10154 300267000036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 300267000037 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 300267000038 nucleotide binding site [chemical binding]; other site 300267000039 NEF interaction site [polypeptide binding]; other site 300267000040 SBD interface [polypeptide binding]; other site 300267000041 chaperone protein DnaJ; Provisional; Region: PRK10767 300267000042 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 300267000043 HSP70 interaction site [polypeptide binding]; other site 300267000044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 300267000045 substrate binding site [polypeptide binding]; other site 300267000046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 300267000047 Zn binding sites [ion binding]; other site 300267000048 dimer interface [polypeptide binding]; other site 300267000049 Hok/gef family; Region: HOK_GEF; pfam01848 300267000050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000051 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000052 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000053 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 300267000054 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 300267000055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267000056 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 300267000057 putative dimerization interface [polypeptide binding]; other site 300267000058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000059 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000060 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000061 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000062 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000064 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000065 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000066 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 300267000067 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 300267000068 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 300267000069 substrate binding site [chemical binding]; other site 300267000070 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 300267000071 substrate binding site [chemical binding]; other site 300267000072 ligand binding site [chemical binding]; other site 300267000073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112 300267000074 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 300267000075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267000076 S-adenosylmethionine binding site [chemical binding]; other site 300267000077 multicopper oxidase; Provisional; Region: PRK10965 300267000078 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 300267000079 Domain 2 interface [polypeptide binding]; other site 300267000080 Domain 3 interface [polypeptide binding]; other site 300267000081 trinuclear Cu binding site [ion binding]; other site 300267000082 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 300267000083 Domain 1 interface [polypeptide binding]; other site 300267000084 Domain 3 interface [polypeptide binding]; other site 300267000085 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 300267000086 Domain 2 interface [polypeptide binding]; other site 300267000087 Domain 1 interface [polypeptide binding]; other site 300267000088 Type 1 (T1) Cu binding site [ion binding]; other site 300267000089 trinuclear Cu binding site [ion binding]; other site 300267000090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000091 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000092 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000093 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 300267000095 active site 300267000096 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 300267000097 active site clefts [active] 300267000098 zinc binding site [ion binding]; other site 300267000099 dimer interface [polypeptide binding]; other site 300267000100 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 300267000101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 300267000102 Walker A/P-loop; other site 300267000103 ATP binding site [chemical binding]; other site 300267000104 Q-loop/lid; other site 300267000105 ABC transporter signature motif; other site 300267000106 Walker B; other site 300267000107 D-loop; other site 300267000108 H-loop/switch region; other site 300267000109 inner membrane transport permease; Provisional; Region: PRK15066 300267000110 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 300267000111 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 300267000112 active pocket/dimerization site; other site 300267000113 active site 300267000114 phosphorylation site [posttranslational modification] 300267000115 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 300267000116 tetramerization interface [polypeptide binding]; other site 300267000117 active site 300267000118 Uncharacterized conserved protein [Function unknown]; Region: COG5464 300267000119 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 300267000120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000121 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000122 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000123 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000124 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 300267000125 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 300267000126 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 300267000127 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 300267000128 active site 300267000129 Riboflavin kinase; Region: Flavokinase; smart00904 300267000130 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 300267000131 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 300267000132 active site 300267000133 HIGH motif; other site 300267000134 KMSKS motif; other site 300267000135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 300267000136 tRNA binding surface [nucleotide binding]; other site 300267000137 anticodon binding site; other site 300267000138 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 300267000139 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 300267000140 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 300267000141 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 300267000142 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 300267000143 Fe-S cluster binding site [ion binding]; other site 300267000144 substrate binding site [chemical binding]; other site 300267000145 catalytic site [active] 300267000146 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 300267000147 active site 300267000148 tetramer interface [polypeptide binding]; other site 300267000149 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 300267000150 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 300267000151 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 300267000152 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 300267000153 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 300267000154 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 300267000155 catalytic site [active] 300267000156 subunit interface [polypeptide binding]; other site 300267000157 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 300267000158 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 300267000159 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 300267000160 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 300267000161 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 300267000162 ATP-grasp domain; Region: ATP-grasp_4; cl17255 300267000163 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 300267000164 IMP binding site; other site 300267000165 dimer interface [polypeptide binding]; other site 300267000166 interdomain contacts; other site 300267000167 partial ornithine binding site; other site 300267000168 carnitine operon protein CaiE; Provisional; Region: PRK13627 300267000169 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 300267000170 putative trimer interface [polypeptide binding]; other site 300267000171 putative metal binding site [ion binding]; other site 300267000172 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 300267000173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 300267000174 substrate binding site [chemical binding]; other site 300267000175 oxyanion hole (OAH) forming residues; other site 300267000176 trimer interface [polypeptide binding]; other site 300267000177 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 300267000178 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 300267000179 acyl-activating enzyme (AAE) consensus motif; other site 300267000180 putative AMP binding site [chemical binding]; other site 300267000181 putative active site [active] 300267000182 putative CoA binding site [chemical binding]; other site 300267000183 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 300267000184 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 300267000185 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 300267000186 active site 300267000187 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 300267000188 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 300267000189 Ligand binding site [chemical binding]; other site 300267000190 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 300267000191 Electron transfer flavoprotein domain; Region: ETF; pfam01012 300267000192 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 300267000193 ferredoxin-like protein FixX; Provisional; Region: PRK15449 300267000194 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 300267000195 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 300267000196 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 300267000197 TrkA-N domain; Region: TrkA_N; pfam02254 300267000198 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 300267000199 folate binding site [chemical binding]; other site 300267000200 NADP+ binding site [chemical binding]; other site 300267000201 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 300267000202 CcdB protein; Region: CcdB; pfam01845 300267000203 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 300267000204 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 300267000205 active site 300267000206 metal binding site [ion binding]; metal-binding site 300267000207 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 300267000208 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 300267000209 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 300267000210 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 300267000211 SurA N-terminal domain; Region: SurA_N; pfam09312 300267000212 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 300267000213 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 300267000214 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 300267000215 OstA-like protein; Region: OstA; pfam03968 300267000216 Organic solvent tolerance protein; Region: OstA_C; pfam04453 300267000217 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 300267000218 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 300267000219 putative metal binding site [ion binding]; other site 300267000220 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 300267000221 HSP70 interaction site [polypeptide binding]; other site 300267000222 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 300267000223 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 300267000224 active site 300267000225 ATP-dependent helicase HepA; Validated; Region: PRK04914 300267000226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267000227 ATP binding site [chemical binding]; other site 300267000228 putative Mg++ binding site [ion binding]; other site 300267000229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267000230 nucleotide binding region [chemical binding]; other site 300267000231 ATP-binding site [chemical binding]; other site 300267000232 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 300267000233 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000235 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000236 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000238 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000239 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000240 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000241 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 300267000242 intersubunit interface [polypeptide binding]; other site 300267000243 active site 300267000244 Zn2+ binding site [ion binding]; other site 300267000245 L-arabinose isomerase; Provisional; Region: PRK02929 300267000246 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 300267000247 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 300267000248 trimer interface [polypeptide binding]; other site 300267000249 putative substrate binding site [chemical binding]; other site 300267000250 putative metal binding site [ion binding]; other site 300267000251 ribulokinase; Provisional; Region: PRK04123 300267000252 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 300267000253 N- and C-terminal domain interface [polypeptide binding]; other site 300267000254 active site 300267000255 MgATP binding site [chemical binding]; other site 300267000256 catalytic site [active] 300267000257 metal binding site [ion binding]; metal-binding site 300267000258 carbohydrate binding site [chemical binding]; other site 300267000259 homodimer interface [polypeptide binding]; other site 300267000260 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 300267000261 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 300267000262 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 300267000263 Walker A/P-loop; other site 300267000264 ATP binding site [chemical binding]; other site 300267000265 Q-loop/lid; other site 300267000266 ABC transporter signature motif; other site 300267000267 Walker B; other site 300267000268 D-loop; other site 300267000269 H-loop/switch region; other site 300267000270 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 300267000271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267000272 dimer interface [polypeptide binding]; other site 300267000273 conserved gate region; other site 300267000274 putative PBP binding loops; other site 300267000275 ABC-ATPase subunit interface; other site 300267000276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267000277 dimer interface [polypeptide binding]; other site 300267000278 conserved gate region; other site 300267000279 putative PBP binding loops; other site 300267000280 ABC-ATPase subunit interface; other site 300267000281 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 300267000282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000283 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000284 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000285 transcriptional regulator SgrR; Provisional; Region: PRK13626 300267000286 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 300267000287 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 300267000288 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 300267000289 substrate binding site [chemical binding]; other site 300267000290 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 300267000291 substrate binding site [chemical binding]; other site 300267000292 ligand binding site [chemical binding]; other site 300267000293 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 300267000294 2-isopropylmalate synthase; Validated; Region: PRK00915 300267000295 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 300267000296 active site 300267000297 catalytic residues [active] 300267000298 metal binding site [ion binding]; metal-binding site 300267000299 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 300267000300 leu operon leader peptide; Provisional; Region: PRK09925 300267000301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000302 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000303 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000304 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000306 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000307 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000308 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 300267000309 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 300267000310 PYR/PP interface [polypeptide binding]; other site 300267000311 dimer interface [polypeptide binding]; other site 300267000312 TPP binding site [chemical binding]; other site 300267000313 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 300267000314 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 300267000315 TPP-binding site [chemical binding]; other site 300267000316 dimer interface [polypeptide binding]; other site 300267000317 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 300267000318 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 300267000319 putative valine binding site [chemical binding]; other site 300267000320 dimer interface [polypeptide binding]; other site 300267000321 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 300267000322 similar to fruR leader peptide 300267000323 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 300267000324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267000325 DNA binding site [nucleotide binding] 300267000326 domain linker motif; other site 300267000327 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 300267000328 dimerization interface [polypeptide binding]; other site 300267000329 ligand binding site [chemical binding]; other site 300267000330 mraZ protein; Region: TIGR00242 300267000331 MraZ protein; Region: MraZ; pfam02381 300267000332 MraZ protein; Region: MraZ; pfam02381 300267000333 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 300267000334 cell division protein FtsL; Provisional; Region: PRK10772 300267000335 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 300267000336 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 300267000337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 300267000338 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 300267000339 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 300267000340 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 300267000341 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 300267000342 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 300267000343 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 300267000344 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 300267000345 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 300267000346 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 300267000347 Mg++ binding site [ion binding]; other site 300267000348 putative catalytic motif [active] 300267000349 putative substrate binding site [chemical binding]; other site 300267000350 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 300267000351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 300267000352 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 300267000353 cell division protein FtsW; Provisional; Region: PRK10774 300267000354 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 300267000355 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 300267000356 active site 300267000357 homodimer interface [polypeptide binding]; other site 300267000358 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 300267000359 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 300267000360 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 300267000361 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 300267000362 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 300267000363 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 300267000364 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 300267000365 cell division protein FtsQ; Provisional; Region: PRK10775 300267000366 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 300267000367 Cell division protein FtsQ; Region: FtsQ; pfam03799 300267000368 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 300267000369 Cell division protein FtsA; Region: FtsA; pfam14450 300267000370 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267000371 Cell division protein FtsA; Region: FtsA; pfam14450 300267000372 cell division protein FtsZ; Validated; Region: PRK09330 300267000373 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 300267000374 nucleotide binding site [chemical binding]; other site 300267000375 SulA interaction site; other site 300267000376 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 300267000377 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 300267000378 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 300267000379 SecA regulator SecM; Provisional; Region: PRK02943 300267000380 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 300267000381 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 300267000382 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 300267000383 SEC-C motif; Region: SEC-C; pfam02810 300267000384 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 300267000385 active site 300267000386 8-oxo-dGMP binding site [chemical binding]; other site 300267000387 nudix motif; other site 300267000388 metal binding site [ion binding]; metal-binding site 300267000389 DNA gyrase inhibitor; Reviewed; Region: PRK00418 300267000390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 300267000391 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 300267000392 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 300267000393 CoA-binding site [chemical binding]; other site 300267000394 ATP-binding [chemical binding]; other site 300267000395 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 300267000396 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 300267000397 active site 300267000398 putative major pilin subunit; Provisional; Region: PRK10574 300267000399 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 300267000400 Pilin (bacterial filament); Region: Pilin; pfam00114 300267000401 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 300267000402 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 300267000403 dimerization interface [polypeptide binding]; other site 300267000404 active site 300267000405 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 300267000406 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 300267000407 amidase catalytic site [active] 300267000408 Zn binding residues [ion binding]; other site 300267000409 substrate binding site [chemical binding]; other site 300267000410 regulatory protein AmpE; Provisional; Region: PRK10987 300267000411 aromatic amino acid transporter; Provisional; Region: PRK10238 300267000412 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267000413 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 300267000414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267000415 DNA-binding site [nucleotide binding]; DNA binding site 300267000416 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 300267000417 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 300267000418 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 300267000419 dimer interface [polypeptide binding]; other site 300267000420 TPP-binding site [chemical binding]; other site 300267000421 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 300267000422 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 300267000423 E3 interaction surface; other site 300267000424 lipoyl attachment site [posttranslational modification]; other site 300267000425 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 300267000426 E3 interaction surface; other site 300267000427 lipoyl attachment site [posttranslational modification]; other site 300267000428 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 300267000429 E3 interaction surface; other site 300267000430 lipoyl attachment site [posttranslational modification]; other site 300267000431 e3 binding domain; Region: E3_binding; pfam02817 300267000432 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 300267000433 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 300267000434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267000435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267000436 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 300267000437 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000439 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000440 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000441 Outer membrane usher protein; Region: Usher; pfam00577 300267000442 PapC C-terminal domain; Region: PapC_C; pfam13953 300267000443 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000445 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000446 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000447 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 300267000448 oligomerization interface [polypeptide binding]; other site 300267000449 active site 300267000450 metal binding site [ion binding]; metal-binding site 300267000451 Pantoate-beta-alanine ligase; Region: PanC; cd00560 300267000452 active site 300267000453 ATP-binding site [chemical binding]; other site 300267000454 pantoate-binding site; other site 300267000455 HXXH motif; other site 300267000456 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000458 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000459 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000460 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000461 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 300267000462 catalytic center binding site [active] 300267000463 ATP binding site [chemical binding]; other site 300267000464 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 300267000465 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 300267000466 active site 300267000467 NTP binding site [chemical binding]; other site 300267000468 metal binding triad [ion binding]; metal-binding site 300267000469 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 300267000470 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 300267000471 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 300267000472 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 300267000473 active site 300267000474 nucleotide binding site [chemical binding]; other site 300267000475 HIGH motif; other site 300267000476 KMSKS motif; other site 300267000477 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 300267000478 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 300267000479 2'-5' RNA ligase; Provisional; Region: PRK15124 300267000480 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 300267000481 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 300267000482 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 300267000483 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 300267000484 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 300267000485 Transglycosylase; Region: Transgly; pfam00912 300267000486 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 300267000487 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 300267000488 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267000489 N-terminal plug; other site 300267000490 ligand-binding site [chemical binding]; other site 300267000491 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 300267000492 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 300267000493 Walker A/P-loop; other site 300267000494 ATP binding site [chemical binding]; other site 300267000495 Q-loop/lid; other site 300267000496 ABC transporter signature motif; other site 300267000497 Walker B; other site 300267000498 D-loop; other site 300267000499 H-loop/switch region; other site 300267000500 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 300267000501 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 300267000502 siderophore binding site; other site 300267000503 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 300267000504 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267000505 ABC-ATPase subunit interface; other site 300267000506 dimer interface [polypeptide binding]; other site 300267000507 putative PBP binding regions; other site 300267000508 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267000509 ABC-ATPase subunit interface; other site 300267000510 dimer interface [polypeptide binding]; other site 300267000511 putative PBP binding regions; other site 300267000512 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 300267000513 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 300267000514 inhibitor-cofactor binding pocket; inhibition site 300267000515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267000516 catalytic residue [active] 300267000517 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 300267000518 Cl- selectivity filter; other site 300267000519 Cl- binding residues [ion binding]; other site 300267000520 pore gating glutamate residue; other site 300267000521 dimer interface [polypeptide binding]; other site 300267000522 H+/Cl- coupling transport residue; other site 300267000523 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 300267000524 hypothetical protein; Provisional; Region: PRK10578 300267000525 UPF0126 domain; Region: UPF0126; pfam03458 300267000526 UPF0126 domain; Region: UPF0126; pfam03458 300267000527 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 300267000528 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 300267000529 cobalamin binding residues [chemical binding]; other site 300267000530 putative BtuC binding residues; other site 300267000531 dimer interface [polypeptide binding]; other site 300267000532 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 300267000533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000534 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000535 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000536 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000537 serine endoprotease; Provisional; Region: PRK10942 300267000538 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 300267000539 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 300267000540 protein binding site [polypeptide binding]; other site 300267000541 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 300267000542 protein binding site [polypeptide binding]; other site 300267000543 hypothetical protein; Provisional; Region: PRK13677 300267000544 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 300267000545 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 300267000546 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 300267000547 trimer interface [polypeptide binding]; other site 300267000548 active site 300267000549 substrate binding site [chemical binding]; other site 300267000550 CoA binding site [chemical binding]; other site 300267000551 PII uridylyl-transferase; Provisional; Region: PRK05007 300267000552 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 300267000553 metal binding triad; other site 300267000554 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 300267000555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 300267000556 Zn2+ binding site [ion binding]; other site 300267000557 Mg2+ binding site [ion binding]; other site 300267000558 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 300267000559 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 300267000560 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 300267000561 active site 300267000562 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 300267000563 rRNA interaction site [nucleotide binding]; other site 300267000564 S8 interaction site; other site 300267000565 putative laminin-1 binding site; other site 300267000566 elongation factor Ts; Provisional; Region: tsf; PRK09377 300267000567 UBA/TS-N domain; Region: UBA; pfam00627 300267000568 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 300267000569 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 300267000570 putative nucleotide binding site [chemical binding]; other site 300267000571 uridine monophosphate binding site [chemical binding]; other site 300267000572 homohexameric interface [polypeptide binding]; other site 300267000573 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 300267000574 hinge region; other site 300267000575 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 300267000576 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 300267000577 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 300267000578 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 300267000579 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 300267000580 active site 300267000581 dimer interface [polypeptide binding]; other site 300267000582 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 300267000583 zinc metallopeptidase RseP; Provisional; Region: PRK10779 300267000584 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 300267000585 active site 300267000586 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 300267000587 protein binding site [polypeptide binding]; other site 300267000588 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 300267000589 protein binding site [polypeptide binding]; other site 300267000590 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 300267000591 putative substrate binding region [chemical binding]; other site 300267000592 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 300267000593 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 300267000594 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 300267000595 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 300267000596 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 300267000597 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 300267000598 Surface antigen; Region: Bac_surface_Ag; pfam01103 300267000599 periplasmic chaperone; Provisional; Region: PRK10780 300267000600 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 300267000601 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 300267000602 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 300267000603 trimer interface [polypeptide binding]; other site 300267000604 active site 300267000605 UDP-GlcNAc binding site [chemical binding]; other site 300267000606 lipid binding site [chemical binding]; lipid-binding site 300267000607 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 300267000608 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 300267000609 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 300267000610 active site 300267000611 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 300267000612 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 300267000613 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 300267000614 RNA/DNA hybrid binding site [nucleotide binding]; other site 300267000615 active site 300267000616 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 300267000617 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 300267000618 putative active site [active] 300267000619 putative PHP Thumb interface [polypeptide binding]; other site 300267000620 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 300267000621 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 300267000622 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 300267000623 generic binding surface II; other site 300267000624 generic binding surface I; other site 300267000625 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 300267000626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000627 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000628 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000629 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000630 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 300267000631 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 300267000632 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 300267000633 Ligand Binding Site [chemical binding]; other site 300267000634 TilS substrate binding domain; Region: TilS; pfam09179 300267000635 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 300267000636 Rho-binding antiterminator; Provisional; Region: PRK11625 300267000637 hypothetical protein; Provisional; Region: PRK04964 300267000638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 300267000639 hypothetical protein; Provisional; Region: PRK09256 300267000640 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 300267000641 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 300267000642 Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015 300267000643 hypothetical protein; Provisional; Region: PRK11479 300267000644 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 300267000645 prolyl-tRNA synthetase; Provisional; Region: PRK09194 300267000646 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 300267000647 dimer interface [polypeptide binding]; other site 300267000648 motif 1; other site 300267000649 active site 300267000650 motif 2; other site 300267000651 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 300267000652 putative deacylase active site [active] 300267000653 motif 3; other site 300267000654 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 300267000655 anticodon binding site; other site 300267000656 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 300267000657 homodimer interaction site [polypeptide binding]; other site 300267000658 cofactor binding site; other site 300267000659 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 300267000660 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 300267000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267000662 dimer interface [polypeptide binding]; other site 300267000663 conserved gate region; other site 300267000664 putative PBP binding loops; other site 300267000665 ABC-ATPase subunit interface; other site 300267000666 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 300267000667 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 300267000668 Walker A/P-loop; other site 300267000669 ATP binding site [chemical binding]; other site 300267000670 Q-loop/lid; other site 300267000671 ABC transporter signature motif; other site 300267000672 Walker B; other site 300267000673 D-loop; other site 300267000674 H-loop/switch region; other site 300267000675 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 300267000676 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 300267000677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267000678 active site 300267000679 motif I; other site 300267000680 motif II; other site 300267000681 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 300267000682 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 300267000683 active site 300267000684 catalytic tetrad [active] 300267000685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 300267000686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267000687 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 300267000688 putative effector binding pocket; other site 300267000689 dimerization interface [polypeptide binding]; other site 300267000690 hypothetical protein; Provisional; Region: PRK05421 300267000691 putative catalytic site [active] 300267000692 putative metal binding site [ion binding]; other site 300267000693 putative phosphate binding site [ion binding]; other site 300267000694 putative catalytic site [active] 300267000695 putative phosphate binding site [ion binding]; other site 300267000696 putative metal binding site [ion binding]; other site 300267000697 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 300267000698 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 300267000699 N-acetyl-D-glucosamine binding site [chemical binding]; other site 300267000700 catalytic residue [active] 300267000701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 300267000702 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 300267000703 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 300267000704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267000705 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 300267000706 RNA/DNA hybrid binding site [nucleotide binding]; other site 300267000707 active site 300267000708 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 300267000709 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 300267000710 active site 300267000711 catalytic site [active] 300267000712 substrate binding site [chemical binding]; other site 300267000713 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000715 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000716 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000718 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000719 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000721 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000722 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000723 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000724 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 300267000725 putative active site [active] 300267000726 catalytic triad [active] 300267000727 dimer interface [polypeptide binding]; other site 300267000728 multimer interface [polypeptide binding]; other site 300267000729 C-lysozyme inhibitor; Provisional; Region: PRK09993 300267000730 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 300267000731 dimer interface [polypeptide binding]; other site 300267000732 active site 300267000733 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 300267000734 putative active site [active] 300267000735 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 300267000736 putative dimer interface [polypeptide binding]; other site 300267000737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 300267000738 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 300267000739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 300267000740 RelB antitoxin; Region: RelB; pfam04221 300267000741 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 300267000742 NlpC/P60 family; Region: NLPC_P60; pfam00877 300267000743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 300267000744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000745 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000746 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000747 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000748 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 300267000749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000750 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000751 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000752 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000753 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000755 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000756 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000758 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000759 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000760 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000761 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000762 membrane protein FdrA; Validated; Region: PRK06091 300267000763 CoA binding domain; Region: CoA_binding; pfam02629 300267000764 CoA-ligase; Region: Ligase_CoA; pfam00549 300267000765 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 300267000766 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 300267000767 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000769 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000770 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000771 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 300267000772 ATP-grasp domain; Region: ATP-grasp; pfam02222 300267000773 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 300267000774 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 300267000775 putative active site [active] 300267000776 putative metal binding site [ion binding]; other site 300267000777 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 300267000778 substrate binding site [chemical binding]; other site 300267000779 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 300267000780 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 300267000781 active site 300267000782 HIGH motif; other site 300267000783 KMSKS motif; other site 300267000784 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 300267000785 tRNA binding surface [nucleotide binding]; other site 300267000786 anticodon binding site; other site 300267000787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267000788 RNA binding surface [nucleotide binding]; other site 300267000789 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 300267000790 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 300267000791 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 300267000792 homodimer interface [polypeptide binding]; other site 300267000793 NADP binding site [chemical binding]; other site 300267000794 substrate binding site [chemical binding]; other site 300267000795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000796 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000797 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000798 HTH-like domain; Region: HTH_21; pfam13276 300267000799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267000800 Integrase core domain; Region: rve; pfam00665 300267000801 Integrase core domain; Region: rve_3; pfam13683 300267000802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267000803 Transposase; Region: HTH_Tnp_1; pfam01527 300267000804 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 300267000805 Ligand Binding Site [chemical binding]; other site 300267000806 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 300267000807 active site 300267000808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000809 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000810 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000811 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 300267000812 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 300267000813 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 300267000814 periplasmic folding chaperone; Provisional; Region: PRK10788 300267000815 SurA N-terminal domain; Region: SurA_N_3; cl07813 300267000816 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 300267000817 histone-like DNA-binding protein HU; Region: HU; cd13831 300267000818 dimer interface [polypeptide binding]; other site 300267000819 DNA binding site [nucleotide binding] 300267000820 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 300267000821 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 300267000822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267000823 Walker A motif; other site 300267000824 ATP binding site [chemical binding]; other site 300267000825 Walker B motif; other site 300267000826 arginine finger; other site 300267000827 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 300267000828 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 300267000829 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 300267000830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267000831 Walker A motif; other site 300267000832 ATP binding site [chemical binding]; other site 300267000833 Walker B motif; other site 300267000834 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 300267000835 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 300267000836 oligomer interface [polypeptide binding]; other site 300267000837 active site residues [active] 300267000838 trigger factor; Provisional; Region: tig; PRK01490 300267000839 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 300267000840 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 300267000841 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 300267000842 transcriptional regulator BolA; Provisional; Region: PRK11628 300267000843 hypothetical protein; Provisional; Region: PRK11627 300267000844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267000845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 300267000846 putative substrate translocation pore; other site 300267000847 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000849 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000850 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267000852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 300267000853 putative substrate translocation pore; other site 300267000854 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 300267000855 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 300267000856 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 300267000857 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 300267000858 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 300267000859 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 300267000860 conserved cys residue [active] 300267000861 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 300267000862 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 300267000863 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 300267000864 Ligand Binding Site [chemical binding]; other site 300267000865 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 300267000866 active site residue [active] 300267000867 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 300267000868 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 300267000869 substrate binding pocket [chemical binding]; other site 300267000870 chain length determination region; other site 300267000871 active site lid residues [active] 300267000872 substrate-Mg2+ binding site; other site 300267000873 catalytic residues [active] 300267000874 aspartate-rich region 1; other site 300267000875 aspartate-rich region 2; other site 300267000876 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 300267000877 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 300267000878 TPP-binding site; other site 300267000879 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 300267000880 PYR/PP interface [polypeptide binding]; other site 300267000881 dimer interface [polypeptide binding]; other site 300267000882 TPP binding site [chemical binding]; other site 300267000883 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 300267000884 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 300267000885 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 300267000886 active site 300267000887 catalytic tetrad [active] 300267000888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000889 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000890 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000891 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000892 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000894 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000895 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000896 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 300267000897 tetramer interfaces [polypeptide binding]; other site 300267000898 binuclear metal-binding site [ion binding]; other site 300267000899 thiamine monophosphate kinase; Provisional; Region: PRK05731 300267000900 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 300267000901 ATP binding site [chemical binding]; other site 300267000902 dimerization interface [polypeptide binding]; other site 300267000903 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 300267000904 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 300267000905 homopentamer interface [polypeptide binding]; other site 300267000906 active site 300267000907 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 300267000908 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 300267000909 catalytic motif [active] 300267000910 Zn binding site [ion binding]; other site 300267000911 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 300267000912 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 300267000913 ATP cone domain; Region: ATP-cone; pfam03477 300267000914 hypothetical protein; Provisional; Region: PRK11530 300267000915 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 300267000916 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 300267000917 active site 300267000918 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 300267000919 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 300267000920 Protein export membrane protein; Region: SecD_SecF; pfam02355 300267000921 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 300267000922 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 300267000923 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 300267000924 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 300267000925 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 300267000926 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 300267000927 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 300267000928 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 300267000929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000930 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000931 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000932 putative proline-specific permease; Provisional; Region: proY; PRK10580 300267000933 Spore germination protein; Region: Spore_permease; cl17796 300267000934 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 300267000935 transcriptional regulator PhoB; Provisional; Region: PRK10161 300267000936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267000937 active site 300267000938 phosphorylation site [posttranslational modification] 300267000939 intermolecular recognition site; other site 300267000940 dimerization interface [polypeptide binding]; other site 300267000941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267000942 DNA binding site [nucleotide binding] 300267000943 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267000944 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267000945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267000946 exonuclease subunit SbcC; Provisional; Region: PRK10246 300267000947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267000948 Walker A/P-loop; other site 300267000949 ATP binding site [chemical binding]; other site 300267000950 Q-loop/lid; other site 300267000951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267000952 ABC transporter signature motif; other site 300267000953 Walker B; other site 300267000954 D-loop; other site 300267000955 H-loop/switch region; other site 300267000956 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000957 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 300267000958 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267000959 nucleotide binding site [chemical binding]; other site 300267000960 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 300267000961 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267000962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000963 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000964 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000965 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267000966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267000967 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267000968 HTH-like domain; Region: HTH_21; pfam13276 300267000969 Integrase core domain; Region: rve; pfam00665 300267000970 Integrase core domain; Region: rve_3; pfam13683 300267000971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267000972 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267000973 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267000974 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267000975 hypothetical protein; Provisional; Region: PRK10579 300267000976 hypothetical protein; Provisional; Region: PRK10481 300267000977 hypothetical protein; Provisional; Region: PRK10380 300267000978 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 300267000979 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 300267000980 ADP binding site [chemical binding]; other site 300267000981 magnesium binding site [ion binding]; other site 300267000982 putative shikimate binding site; other site 300267000983 hypothetical protein; Validated; Region: PRK00124 300267000984 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 300267000985 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 300267000986 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 300267000987 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 300267000988 MASE2 domain; Region: MASE2; pfam05230 300267000989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267000990 metal binding site [ion binding]; metal-binding site 300267000991 active site 300267000992 I-site; other site 300267000993 HTH-like domain; Region: HTH_21; pfam13276 300267000994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267000995 Integrase core domain; Region: rve; pfam00665 300267000996 Integrase core domain; Region: rve_3; pfam13683 300267000997 hypothetical protein; Provisional; Region: PRK11505 300267000998 psiF repeat; Region: PsiF_repeat; pfam07769 300267000999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001000 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001001 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001002 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001003 anti-RssB factor; Provisional; Region: PRK10244 300267001004 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001006 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001007 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001008 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 300267001009 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 300267001010 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 300267001011 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 300267001012 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 300267001013 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 300267001014 microcin B17 transporter; Reviewed; Region: PRK11098 300267001015 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 300267001016 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 300267001017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001018 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001019 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001020 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001021 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 300267001022 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001024 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001025 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001027 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001028 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001029 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001030 lac repressor; Reviewed; Region: lacI; PRK09526 300267001031 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267001032 DNA binding site [nucleotide binding] 300267001033 domain linker motif; other site 300267001034 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 300267001035 ligand binding site [chemical binding]; other site 300267001036 dimerization interface (open form) [polypeptide binding]; other site 300267001037 dimerization interface (closed form) [polypeptide binding]; other site 300267001038 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 300267001039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267001040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001041 Transposase; Region: HTH_Tnp_1; pfam01527 300267001042 HTH-like domain; Region: HTH_21; pfam13276 300267001043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267001044 Integrase core domain; Region: rve; pfam00665 300267001045 Integrase core domain; Region: rve_3; pfam13683 300267001046 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 300267001047 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 300267001048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 300267001049 dimerization interface [polypeptide binding]; other site 300267001050 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 300267001051 putative DNA binding site [nucleotide binding]; other site 300267001052 putative Zn2+ binding site [ion binding]; other site 300267001053 AsnC family; Region: AsnC_trans_reg; pfam01037 300267001054 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267001055 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 300267001056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267001057 Walker A/P-loop; other site 300267001058 ATP binding site [chemical binding]; other site 300267001059 Q-loop/lid; other site 300267001060 ABC transporter signature motif; other site 300267001061 Walker B; other site 300267001062 D-loop; other site 300267001063 H-loop/switch region; other site 300267001064 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 300267001065 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267001066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267001067 Walker A/P-loop; other site 300267001068 ATP binding site [chemical binding]; other site 300267001069 Q-loop/lid; other site 300267001070 ABC transporter signature motif; other site 300267001071 Walker B; other site 300267001072 D-loop; other site 300267001073 H-loop/switch region; other site 300267001074 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 300267001075 ammonium transporter; Provisional; Region: PRK10666 300267001076 acyl-CoA thioesterase II; Provisional; Region: PRK10526 300267001077 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 300267001078 active site 300267001079 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 300267001080 catalytic triad [active] 300267001081 dimer interface [polypeptide binding]; other site 300267001082 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 300267001083 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 300267001084 DNA binding site [nucleotide binding] 300267001085 active site 300267001086 Uncharacterized conserved protein [Function unknown]; Region: COG5507 300267001087 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 300267001088 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 300267001089 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 300267001090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001091 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001092 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001093 glyoxylate carboligase; Provisional; Region: PRK11269 300267001094 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 300267001095 PYR/PP interface [polypeptide binding]; other site 300267001096 dimer interface [polypeptide binding]; other site 300267001097 TPP binding site [chemical binding]; other site 300267001098 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 300267001099 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 300267001100 TPP-binding site [chemical binding]; other site 300267001101 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 300267001102 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 300267001103 Bacterial transcriptional regulator; Region: IclR; pfam01614 300267001104 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 300267001105 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 300267001106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267001107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 300267001108 dimerization interface [polypeptide binding]; other site 300267001109 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 300267001110 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 300267001111 active site residue [active] 300267001112 Winged helix-turn helix; Region: HTH_29; pfam13551 300267001113 Helix-turn-helix domain; Region: HTH_28; pfam13518 300267001114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001115 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001116 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001117 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001118 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 300267001119 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 300267001120 Walker A/P-loop; other site 300267001121 ATP binding site [chemical binding]; other site 300267001122 Q-loop/lid; other site 300267001123 ABC transporter signature motif; other site 300267001124 Walker B; other site 300267001125 D-loop; other site 300267001126 H-loop/switch region; other site 300267001127 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 300267001128 active site 300267001129 catalytic triad [active] 300267001130 oxyanion hole [active] 300267001131 switch loop; other site 300267001132 short chain dehydrogenase; Validated; Region: PRK06182 300267001133 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 300267001134 NADP binding site [chemical binding]; other site 300267001135 active site 300267001136 steroid binding site; other site 300267001137 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 300267001138 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 300267001139 Tetratricopeptide repeat; Region: TPR_20; pfam14561 300267001140 TIGR00245 family protein; Region: TIGR00245 300267001141 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 300267001142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267001143 Walker A/P-loop; other site 300267001144 ATP binding site [chemical binding]; other site 300267001145 Q-loop/lid; other site 300267001146 ABC transporter signature motif; other site 300267001147 Walker B; other site 300267001148 D-loop; other site 300267001149 H-loop/switch region; other site 300267001150 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 300267001151 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 300267001152 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 300267001153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001154 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001155 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001156 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001157 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 300267001158 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 300267001159 DNA binding residues [nucleotide binding] 300267001160 dimer interface [polypeptide binding]; other site 300267001161 copper binding site [ion binding]; other site 300267001162 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 300267001163 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 300267001164 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267001165 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267001166 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 300267001167 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 300267001168 Walker A/P-loop; other site 300267001169 ATP binding site [chemical binding]; other site 300267001170 Q-loop/lid; other site 300267001171 ABC transporter signature motif; other site 300267001172 Walker B; other site 300267001173 D-loop; other site 300267001174 H-loop/switch region; other site 300267001175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001176 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001177 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001178 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001180 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001181 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001182 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001183 amino acid transporter; Region: 2A0306; TIGR00909 300267001184 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 300267001185 copper exporting ATPase; Provisional; Region: copA; PRK10671 300267001186 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 300267001187 metal-binding site [ion binding] 300267001188 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 300267001189 metal-binding site [ion binding] 300267001190 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 300267001191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267001192 motif II; other site 300267001193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267001194 sequence-specific DNA binding site [nucleotide binding]; other site 300267001195 salt bridge; other site 300267001196 TraB family; Region: TraB; cl12050 300267001197 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 300267001198 putative deacylase active site [active] 300267001199 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 300267001200 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 300267001201 active site 300267001202 metal binding site [ion binding]; metal-binding site 300267001203 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 300267001204 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267001205 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267001206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267001207 putative cation:proton antiport protein; Provisional; Region: PRK10669 300267001208 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 300267001209 TrkA-N domain; Region: TrkA_N; pfam02254 300267001210 inosine/guanosine kinase; Provisional; Region: PRK15074 300267001211 adenosine kinase; Provisional; Region: PTZ00247 300267001212 substrate binding site [chemical binding]; other site 300267001213 ATP binding site [chemical binding]; other site 300267001214 ferrochelatase; Region: hemH; TIGR00109 300267001215 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 300267001216 C-terminal domain interface [polypeptide binding]; other site 300267001217 active site 300267001218 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 300267001219 active site 300267001220 N-terminal domain interface [polypeptide binding]; other site 300267001221 adenylate kinase; Reviewed; Region: adk; PRK00279 300267001222 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 300267001223 AMP-binding site [chemical binding]; other site 300267001224 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 300267001225 heat shock protein 90; Provisional; Region: PRK05218 300267001226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267001227 ATP binding site [chemical binding]; other site 300267001228 Mg2+ binding site [ion binding]; other site 300267001229 G-X-G motif; other site 300267001230 Hsp90 protein; Region: HSP90; pfam00183 300267001231 recombination protein RecR; Reviewed; Region: recR; PRK00076 300267001232 RecR protein; Region: RecR; pfam02132 300267001233 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 300267001234 putative active site [active] 300267001235 putative metal-binding site [ion binding]; other site 300267001236 tetramer interface [polypeptide binding]; other site 300267001237 hypothetical protein; Validated; Region: PRK00153 300267001238 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 300267001239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267001240 Walker A motif; other site 300267001241 ATP binding site [chemical binding]; other site 300267001242 Walker B motif; other site 300267001243 DNA polymerase III subunit delta'; Validated; Region: PRK08485 300267001244 arginine finger; other site 300267001245 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 300267001246 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 300267001247 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 300267001248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 300267001249 active site 300267001250 hypothetical protein; Provisional; Region: PRK10527 300267001251 primosomal replication protein N''; Provisional; Region: PRK10093 300267001252 hypothetical protein; Provisional; Region: PRK11038 300267001253 hypothetical protein; Provisional; Region: PRK11281 300267001254 FSIP1 family; Region: FSIP1; pfam15554 300267001255 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 300267001256 Mechanosensitive ion channel; Region: MS_channel; pfam00924 300267001257 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 300267001258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267001259 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 300267001260 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 300267001261 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 300267001262 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267001263 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 300267001264 MMPL family; Region: MMPL; cl14618 300267001265 MMPL family; Region: MMPL; cl14618 300267001266 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 300267001267 gene expression modulator; Provisional; Region: PRK10945 300267001268 maltose O-acetyltransferase; Provisional; Region: PRK10092 300267001269 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 300267001270 active site 300267001271 substrate binding site [chemical binding]; other site 300267001272 trimer interface [polypeptide binding]; other site 300267001273 CoA binding site [chemical binding]; other site 300267001274 Inner membrane protein YlaC; Region: YlaC; pfam10777 300267001275 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 300267001276 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267001277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001278 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267001279 HTH-like domain; Region: HTH_21; pfam13276 300267001280 Integrase core domain; Region: rve; pfam00665 300267001281 Integrase core domain; Region: rve_3; pfam13683 300267001282 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001284 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001285 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001287 Transposase; Region: HTH_Tnp_1; cl17663 300267001288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001289 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001290 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001291 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001292 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 300267001293 putative catalytic cysteine [active] 300267001294 gamma-glutamyl kinase; Provisional; Region: PRK05429 300267001295 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 300267001296 nucleotide binding site [chemical binding]; other site 300267001297 homotetrameric interface [polypeptide binding]; other site 300267001298 putative phosphate binding site [ion binding]; other site 300267001299 putative allosteric binding site; other site 300267001300 PUA domain; Region: PUA; pfam01472 300267001301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001302 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001303 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001304 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001305 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 300267001306 Putative lysophospholipase; Region: Hydrolase_4; cl19140 300267001307 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 300267001308 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 300267001309 active site 300267001310 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 300267001311 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 300267001312 metal binding site [ion binding]; metal-binding site 300267001313 dimer interface [polypeptide binding]; other site 300267001314 RF-1 domain; Region: RF-1; cl17422 300267001315 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 300267001316 Uncharacterized conserved protein [Function unknown]; Region: RtcB; cl17455 300267001317 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 300267001318 active site 300267001319 DNA polymerase IV; Validated; Region: PRK02406 300267001320 DNA binding site [nucleotide binding] 300267001321 hypothetical protein; Validated; Region: PRK06778 300267001322 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 300267001323 ligand binding site [chemical binding]; other site 300267001324 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 300267001325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001326 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001327 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001328 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001329 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001331 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001332 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 300267001333 phenylalanine transporter; Provisional; Region: PRK10249 300267001334 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267001335 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 300267001336 Mechanosensitive ion channel; Region: MS_channel; pfam00924 300267001337 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 300267001338 dimer interface [polypeptide binding]; other site 300267001339 FMN binding site [chemical binding]; other site 300267001340 hypothetical protein; Provisional; Region: PRK10250 300267001341 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 300267001342 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 300267001343 Hok/gef family; Region: HOK_GEF; pfam01848 300267001344 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267001345 HTH-like domain; Region: HTH_21; pfam13276 300267001346 Integrase core domain; Region: rve; pfam00665 300267001347 Integrase core domain; Region: rve_3; pfam13683 300267001348 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267001349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001350 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 300267001351 Autotransporter beta-domain; Region: Autotransporter; smart00869 300267001352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001353 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001354 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001355 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001356 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 300267001357 dimer interface [polypeptide binding]; other site 300267001358 active site 300267001359 Schiff base residues; other site 300267001360 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 300267001361 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 300267001362 active site 300267001363 iron coordination sites [ion binding]; other site 300267001364 substrate binding pocket [chemical binding]; other site 300267001365 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 300267001366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267001367 dimer interface [polypeptide binding]; other site 300267001368 conserved gate region; other site 300267001369 putative PBP binding loops; other site 300267001370 ABC-ATPase subunit interface; other site 300267001371 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 300267001372 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 300267001373 Walker A/P-loop; other site 300267001374 ATP binding site [chemical binding]; other site 300267001375 Q-loop/lid; other site 300267001376 ABC transporter signature motif; other site 300267001377 Walker B; other site 300267001378 D-loop; other site 300267001379 H-loop/switch region; other site 300267001380 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 300267001381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267001382 substrate binding pocket [chemical binding]; other site 300267001383 membrane-bound complex binding site; other site 300267001384 hinge residues; other site 300267001385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 300267001386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267001387 active site 300267001388 phosphorylation site [posttranslational modification] 300267001389 intermolecular recognition site; other site 300267001390 dimerization interface [polypeptide binding]; other site 300267001391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267001392 DNA binding residues [nucleotide binding] 300267001393 dimerization interface [polypeptide binding]; other site 300267001394 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267001395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001396 Hok/gef family; Region: HOK_GEF; pfam01848 300267001397 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 300267001398 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 300267001399 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 300267001400 outer membrane receptor FepA; Provisional; Region: PRK13524 300267001401 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267001402 N-terminal plug; other site 300267001403 ligand-binding site [chemical binding]; other site 300267001404 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 300267001405 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 300267001406 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 300267001407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 300267001408 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 300267001409 Condensation domain; Region: Condensation; cl19241 300267001410 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 300267001411 acyl-activating enzyme (AAE) consensus motif; other site 300267001412 AMP binding site [chemical binding]; other site 300267001413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 300267001414 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 300267001415 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001417 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001418 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001419 LPS O-antigen length regulator; Provisional; Region: PRK10381 300267001420 Chain length determinant protein; Region: Wzz; pfam02706 300267001421 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 300267001422 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 300267001423 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 300267001424 Walker A/P-loop; other site 300267001425 ATP binding site [chemical binding]; other site 300267001426 Q-loop/lid; other site 300267001427 ABC transporter signature motif; other site 300267001428 Walker B; other site 300267001429 D-loop; other site 300267001430 H-loop/switch region; other site 300267001431 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267001432 ABC-ATPase subunit interface; other site 300267001433 dimer interface [polypeptide binding]; other site 300267001434 putative PBP binding regions; other site 300267001435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267001436 ABC-ATPase subunit interface; other site 300267001437 dimer interface [polypeptide binding]; other site 300267001438 putative PBP binding regions; other site 300267001439 enterobactin exporter EntS; Provisional; Region: PRK10489 300267001440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267001441 putative substrate translocation pore; other site 300267001442 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 300267001443 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 300267001444 siderophore binding site; other site 300267001445 isochorismate synthase EntC; Provisional; Region: PRK15016 300267001446 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 300267001447 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 300267001448 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 300267001449 acyl-activating enzyme (AAE) consensus motif; other site 300267001450 active site 300267001451 AMP binding site [chemical binding]; other site 300267001452 substrate binding site [chemical binding]; other site 300267001453 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 300267001454 hydrophobic substrate binding pocket; other site 300267001455 active site 300267001456 conserved cis-peptide bond; other site 300267001457 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 300267001458 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 300267001459 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 300267001460 putative NAD(P) binding site [chemical binding]; other site 300267001461 active site 300267001462 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 300267001463 CoenzymeA binding site [chemical binding]; other site 300267001464 subunit interaction site [polypeptide binding]; other site 300267001465 PHB binding site; other site 300267001466 Uncharacterized small protein [Function unknown]; Region: COG2879 300267001467 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 300267001468 putative active site [active] 300267001469 metal binding site [ion binding]; metal-binding site 300267001470 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 300267001471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001472 Transposase; Region: HTH_Tnp_1; pfam01527 300267001473 HTH-like domain; Region: HTH_21; pfam13276 300267001474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267001475 Integrase core domain; Region: rve; pfam00665 300267001476 Integrase core domain; Region: rve_3; pfam13683 300267001477 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 300267001478 Active Sites [active] 300267001479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001480 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001481 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001482 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001483 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 300267001484 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 300267001485 dimer interface [polypeptide binding]; other site 300267001486 decamer (pentamer of dimers) interface [polypeptide binding]; other site 300267001487 catalytic triad [active] 300267001488 peroxidatic and resolving cysteines [active] 300267001489 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 300267001490 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 300267001491 catalytic residue [active] 300267001492 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 300267001493 catalytic residues [active] 300267001494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267001495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267001496 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 300267001497 Ligand Binding Site [chemical binding]; other site 300267001498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001499 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001500 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001501 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001502 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 300267001503 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 300267001504 DNA-binding site [nucleotide binding]; DNA binding site 300267001505 RNA-binding motif; other site 300267001506 chromosome condensation membrane protein; Provisional; Region: PRK14196 300267001507 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 300267001508 lipoyl synthase; Provisional; Region: PRK05481 300267001509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267001510 FeS/SAM binding site; other site 300267001511 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 300267001512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267001513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 300267001514 dimerization interface [polypeptide binding]; other site 300267001515 lipoate-protein ligase B; Provisional; Region: PRK14342 300267001516 hypothetical protein; Provisional; Region: PRK04998 300267001517 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 300267001518 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 300267001519 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 300267001520 rare lipoprotein A; Provisional; Region: PRK10672 300267001521 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 300267001522 Sporulation related domain; Region: SPOR; pfam05036 300267001523 cell wall shape-determining protein; Provisional; Region: PRK10794 300267001524 penicillin-binding protein 2; Provisional; Region: PRK10795 300267001525 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 300267001526 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 300267001527 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 300267001528 ribosome-associated protein; Provisional; Region: PRK11538 300267001529 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 300267001530 active site 300267001531 (T/H)XGH motif; other site 300267001532 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 300267001533 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 300267001534 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 300267001535 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 300267001536 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 300267001537 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 300267001538 active site 300267001539 HIGH motif; other site 300267001540 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 300267001541 KMSKS motif; other site 300267001542 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 300267001543 tRNA binding surface [nucleotide binding]; other site 300267001544 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 300267001545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001546 Transposase; Region: HTH_Tnp_1; cl17663 300267001547 putative transposase OrfB; Reviewed; Region: PHA02517 300267001548 HTH-like domain; Region: HTH_21; pfam13276 300267001549 Integrase core domain; Region: rve; pfam00665 300267001550 Integrase core domain; Region: rve_3; pfam13683 300267001551 hypothetical protein; Provisional; Region: PRK11032 300267001552 Sel1-like repeats; Region: SEL1; smart00671 300267001553 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 300267001554 Sel1-like repeats; Region: SEL1; smart00671 300267001555 Sel1-like repeats; Region: SEL1; smart00671 300267001556 Sel1-like repeats; Region: SEL1; smart00671 300267001557 Sel1-like repeats; Region: SEL1; smart00671 300267001558 Sel1-like repeats; Region: SEL1; smart00671 300267001559 Sel1-like repeats; Region: SEL1; smart00671 300267001560 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001562 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001563 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001565 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001566 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001567 ORF6N domain; Region: ORF6N; pfam10543 300267001568 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 300267001569 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 300267001570 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 300267001571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001572 Transposase; Region: HTH_Tnp_1; pfam01527 300267001573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001574 Transposase; Region: HTH_Tnp_1; cl17663 300267001575 putative transposase OrfB; Reviewed; Region: PHA02517 300267001576 HTH-like domain; Region: HTH_21; pfam13276 300267001577 Integrase core domain; Region: rve; pfam00665 300267001578 Integrase core domain; Region: rve_3; pfam13683 300267001579 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 300267001580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267001581 dimer interface [polypeptide binding]; other site 300267001582 conserved gate region; other site 300267001583 putative PBP binding loops; other site 300267001584 ABC-ATPase subunit interface; other site 300267001585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001586 Transposase; Region: HTH_Tnp_1; pfam01527 300267001587 HTH-like domain; Region: HTH_21; pfam13276 300267001588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267001589 Integrase core domain; Region: rve; pfam00665 300267001590 Integrase core domain; Region: rve_3; pfam13683 300267001591 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 300267001592 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267001593 substrate binding pocket [chemical binding]; other site 300267001594 membrane-bound complex binding site; other site 300267001595 hinge residues; other site 300267001596 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 300267001597 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 300267001598 putative active site [active] 300267001599 catalytic triad [active] 300267001600 putative dimer interface [polypeptide binding]; other site 300267001601 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 300267001602 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 300267001603 Transporter associated domain; Region: CorC_HlyC; smart01091 300267001604 metal-binding heat shock protein; Provisional; Region: PRK00016 300267001605 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 300267001606 PhoH-like protein; Region: PhoH; pfam02562 300267001607 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 300267001608 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 300267001609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267001610 FeS/SAM binding site; other site 300267001611 TRAM domain; Region: TRAM; pfam01938 300267001612 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 300267001613 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 300267001614 asparagine synthetase B; Provisional; Region: asnB; PRK09431 300267001615 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 300267001616 active site 300267001617 dimer interface [polypeptide binding]; other site 300267001618 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 300267001619 Ligand Binding Site [chemical binding]; other site 300267001620 Molecular Tunnel; other site 300267001621 UMP phosphatase; Provisional; Region: PRK10444 300267001622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267001623 active site 300267001624 motif I; other site 300267001625 motif II; other site 300267001626 MarR family; Region: MarR_2; cl17246 300267001627 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 300267001628 ROK family; Region: ROK; pfam00480 300267001629 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 300267001630 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 300267001631 active site 300267001632 dimer interface [polypeptide binding]; other site 300267001633 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 300267001634 active site 300267001635 trimer interface [polypeptide binding]; other site 300267001636 allosteric site; other site 300267001637 active site lid [active] 300267001638 hexamer (dimer of trimers) interface [polypeptide binding]; other site 300267001639 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 300267001640 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 300267001641 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 300267001642 active site turn [active] 300267001643 phosphorylation site [posttranslational modification] 300267001644 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 300267001645 HPr interaction site; other site 300267001646 glycerol kinase (GK) interaction site [polypeptide binding]; other site 300267001647 active site 300267001648 phosphorylation site [posttranslational modification] 300267001649 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 300267001650 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 300267001651 active site 300267001652 HIGH motif; other site 300267001653 KMSKS motif; other site 300267001654 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 300267001655 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001657 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001658 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001660 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001661 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001662 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 300267001663 metal binding site 2 [ion binding]; metal-binding site 300267001664 putative DNA binding helix; other site 300267001665 metal binding site 1 [ion binding]; metal-binding site 300267001666 dimer interface [polypeptide binding]; other site 300267001667 structural Zn2+ binding site [ion binding]; other site 300267001668 flavodoxin FldA; Validated; Region: PRK09267 300267001669 LexA regulated protein; Provisional; Region: PRK11675 300267001670 acyl-CoA esterase; Provisional; Region: PRK10673 300267001671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 300267001672 replication initiation regulator SeqA; Provisional; Region: PRK11187 300267001673 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 300267001674 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 300267001675 active site 300267001676 substrate binding site [chemical binding]; other site 300267001677 metal binding site [ion binding]; metal-binding site 300267001678 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 300267001679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267001680 active site 300267001681 phosphorylation site [posttranslational modification] 300267001682 intermolecular recognition site; other site 300267001683 dimerization interface [polypeptide binding]; other site 300267001684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267001685 DNA binding site [nucleotide binding] 300267001686 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 300267001687 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 300267001688 PAAR motif; Region: PAAR_motif; cl15808 300267001689 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 300267001690 RHS Repeat; Region: RHS_repeat; pfam05593 300267001691 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 300267001692 RHS Repeat; Region: RHS_repeat; pfam05593 300267001693 RHS Repeat; Region: RHS_repeat; pfam05593 300267001694 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 300267001695 RHS Repeat; Region: RHS_repeat; pfam05593 300267001696 RHS protein; Region: RHS; pfam03527 300267001697 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001699 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001700 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001701 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001703 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001704 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001705 hypothetical protein; Provisional; Region: PRK10167 300267001706 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 300267001707 DNA photolyase; Region: DNA_photolyase; pfam00875 300267001708 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 300267001709 metal-binding protein; Provisional; Region: PRK10799 300267001710 Allophanate hydrolase subunit 1; Region: AHS1; cl19310 300267001711 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 300267001712 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 300267001713 putative active site [active] 300267001714 endonuclease VIII; Provisional; Region: PRK10445 300267001715 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 300267001716 DNA binding site [nucleotide binding] 300267001717 catalytic residue [active] 300267001718 putative catalytic residues [active] 300267001719 H2TH interface [polypeptide binding]; other site 300267001720 intercalation triad [nucleotide binding]; other site 300267001721 substrate specificity determining residue; other site 300267001722 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 300267001723 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 300267001724 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 300267001725 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 300267001726 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 300267001727 Fimbrial protein; Region: Fimbrial; pfam00419 300267001728 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 300267001729 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 300267001730 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 300267001731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001732 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001733 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001734 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267001735 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 300267001736 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001738 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001739 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001740 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 300267001741 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 300267001742 dimer interface [polypeptide binding]; other site 300267001743 active site 300267001744 citrylCoA binding site [chemical binding]; other site 300267001745 NADH binding [chemical binding]; other site 300267001746 cationic pore residues; other site 300267001747 oxalacetate/citrate binding site [chemical binding]; other site 300267001748 coenzyme A binding site [chemical binding]; other site 300267001749 catalytic triad [active] 300267001750 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 300267001751 Iron-sulfur protein interface; other site 300267001752 proximal quinone binding site [chemical binding]; other site 300267001753 SdhD (CybS) interface [polypeptide binding]; other site 300267001754 proximal heme binding site [chemical binding]; other site 300267001755 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 300267001756 SdhC subunit interface [polypeptide binding]; other site 300267001757 proximal heme binding site [chemical binding]; other site 300267001758 cardiolipin binding site; other site 300267001759 Iron-sulfur protein interface; other site 300267001760 proximal quinone binding site [chemical binding]; other site 300267001761 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 300267001762 L-aspartate oxidase; Provisional; Region: PRK06175 300267001763 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 300267001764 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 300267001765 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 300267001766 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 300267001767 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 300267001768 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 300267001769 TPP-binding site [chemical binding]; other site 300267001770 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 300267001771 dimer interface [polypeptide binding]; other site 300267001772 PYR/PP interface [polypeptide binding]; other site 300267001773 TPP binding site [chemical binding]; other site 300267001774 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 300267001775 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 300267001776 E3 interaction surface; other site 300267001777 lipoyl attachment site [posttranslational modification]; other site 300267001778 e3 binding domain; Region: E3_binding; pfam02817 300267001779 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 300267001780 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 300267001781 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 300267001782 CoA-ligase; Region: Ligase_CoA; pfam00549 300267001783 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 300267001784 CoA binding domain; Region: CoA_binding; pfam02629 300267001785 CoA-ligase; Region: Ligase_CoA; pfam00549 300267001786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001787 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001788 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001789 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001791 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001792 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001793 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001794 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 300267001795 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 300267001796 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 300267001797 dimer interface [polypeptide binding]; other site 300267001798 active site 300267001799 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 300267001800 substrate binding site [chemical binding]; other site 300267001801 B12 cofactor binding site [chemical binding]; other site 300267001802 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 300267001803 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 300267001804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 300267001805 conserved hypothetical protein; Region: glmL_fam; TIGR01319 300267001806 nucleotide binding site [chemical binding]; other site 300267001807 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 300267001808 B12 binding site [chemical binding]; other site 300267001809 heterodimer interface [polypeptide binding]; other site 300267001810 cobalt ligand [ion binding]; other site 300267001811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001812 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001813 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001814 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 300267001815 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 300267001816 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 300267001817 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 300267001818 hypothetical protein; Provisional; Region: PRK10588 300267001819 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 300267001820 active site 300267001821 colicin uptake protein TolQ; Provisional; Region: PRK10801 300267001822 colicin uptake protein TolR; Provisional; Region: PRK11024 300267001823 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 300267001824 Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); Region: ClassIIa_HDAC_Gln-rich-N; cl13614 300267001825 TolA C-terminal; Region: TolA; pfam06519 300267001826 translocation protein TolB; Provisional; Region: tolB; PRK03629 300267001827 TolB amino-terminal domain; Region: TolB_N; pfam04052 300267001828 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 300267001829 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 300267001830 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 300267001831 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 300267001832 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 300267001833 ligand binding site [chemical binding]; other site 300267001834 tol-pal system protein YbgF; Provisional; Region: PRK10803 300267001835 Tetratricopeptide repeat; Region: TPR_6; pfam13174 300267001836 Tetratricopeptide repeat; Region: TPR_6; pfam13174 300267001837 quinolinate synthetase; Provisional; Region: PRK09375 300267001838 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 300267001839 zinc transporter ZitB; Provisional; Region: PRK03557 300267001840 YbgS-like protein; Region: YbgS; pfam13985 300267001841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001842 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001843 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001844 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 300267001845 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 300267001846 catalytic core [active] 300267001847 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 300267001848 active site 300267001849 catalytic residues [active] 300267001850 galactokinase; Provisional; Region: PRK05101 300267001851 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 300267001852 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 300267001853 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 300267001854 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 300267001855 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 300267001856 dimer interface [polypeptide binding]; other site 300267001857 active site 300267001858 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 300267001859 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 300267001860 NAD binding site [chemical binding]; other site 300267001861 homodimer interface [polypeptide binding]; other site 300267001862 active site 300267001863 substrate binding site [chemical binding]; other site 300267001864 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 300267001865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 300267001866 Walker A/P-loop; other site 300267001867 ATP binding site [chemical binding]; other site 300267001868 Q-loop/lid; other site 300267001869 ABC transporter signature motif; other site 300267001870 Walker B; other site 300267001871 D-loop; other site 300267001872 H-loop/switch region; other site 300267001873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267001874 Walker A/P-loop; other site 300267001875 ATP binding site [chemical binding]; other site 300267001876 Q-loop/lid; other site 300267001877 ABC transporter signature motif; other site 300267001878 Walker B; other site 300267001879 D-loop; other site 300267001880 H-loop/switch region; other site 300267001881 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 300267001882 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 300267001883 molybdenum-pterin binding domain; Region: Mop; TIGR00638 300267001884 TOBE domain; Region: TOBE; pfam03459 300267001885 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 300267001886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267001887 substrate binding pocket [chemical binding]; other site 300267001888 membrane-bound complex binding site; other site 300267001889 hinge residues; other site 300267001890 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 300267001891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267001892 dimer interface [polypeptide binding]; other site 300267001893 conserved gate region; other site 300267001894 putative PBP binding loops; other site 300267001895 ABC-ATPase subunit interface; other site 300267001896 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 300267001897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267001898 Walker A/P-loop; other site 300267001899 ATP binding site [chemical binding]; other site 300267001900 Q-loop/lid; other site 300267001901 ABC transporter signature motif; other site 300267001902 Walker B; other site 300267001903 D-loop; other site 300267001904 H-loop/switch region; other site 300267001905 molybdenum-pterin binding domain; Region: Mop; TIGR00638 300267001906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001907 Transposase; Region: HTH_Tnp_1; pfam01527 300267001908 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001910 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001911 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001913 Transposase; Region: HTH_Tnp_1; cl17663 300267001914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001915 Transposase; Region: HTH_Tnp_1; cl17663 300267001916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001917 Transposase; Region: HTH_Tnp_1; pfam01527 300267001918 HTH-like domain; Region: HTH_21; pfam13276 300267001919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267001920 Integrase core domain; Region: rve; pfam00665 300267001921 Integrase core domain; Region: rve_3; pfam13683 300267001922 Phage terminase large subunit; Region: Terminase_3; cl12054 300267001923 HTH-like domain; Region: HTH_21; pfam13276 300267001924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267001925 Integrase core domain; Region: rve; pfam00665 300267001926 Integrase core domain; Region: rve_3; pfam13683 300267001927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001928 Transposase; Region: HTH_Tnp_1; pfam01527 300267001929 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267001930 HTH-like domain; Region: HTH_21; pfam13276 300267001931 Integrase core domain; Region: rve; pfam00665 300267001932 Integrase core domain; Region: rve_3; pfam13683 300267001933 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267001934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267001935 Phage portal protein; Region: Phage_portal; cl19194 300267001936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267001937 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267001938 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267001939 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267001940 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 300267001941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267001942 S-adenosylmethionine binding site [chemical binding]; other site 300267001943 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 300267001944 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 300267001945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267001946 dimer interface [polypeptide binding]; other site 300267001947 conserved gate region; other site 300267001948 putative PBP binding loops; other site 300267001949 ABC-ATPase subunit interface; other site 300267001950 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 300267001951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267001952 dimer interface [polypeptide binding]; other site 300267001953 conserved gate region; other site 300267001954 putative PBP binding loops; other site 300267001955 ABC-ATPase subunit interface; other site 300267001956 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 300267001957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267001958 Walker A/P-loop; other site 300267001959 ATP binding site [chemical binding]; other site 300267001960 Q-loop/lid; other site 300267001961 ABC transporter signature motif; other site 300267001962 Walker B; other site 300267001963 D-loop; other site 300267001964 H-loop/switch region; other site 300267001965 TOBE domain; Region: TOBE_2; pfam08402 300267001966 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 300267001967 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 300267001968 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 300267001969 RimK-like ATP-grasp domain; Region: RimK; pfam08443 300267001970 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 300267001971 dimer interface [polypeptide binding]; other site 300267001972 FMN binding site [chemical binding]; other site 300267001973 NADPH bind site [chemical binding]; other site 300267001974 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 300267001975 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 300267001976 GSH binding site [chemical binding]; other site 300267001977 catalytic residues [active] 300267001978 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 300267001979 putative transporter; Provisional; Region: PRK04972 300267001980 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 300267001981 TrkA-C domain; Region: TrkA_C; pfam02080 300267001982 TrkA-C domain; Region: TrkA_C; pfam02080 300267001983 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 300267001984 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 300267001985 trimer interface [polypeptide binding]; other site 300267001986 active site 300267001987 substrate binding site [chemical binding]; other site 300267001988 CoA binding site [chemical binding]; other site 300267001989 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 300267001990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267001991 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 300267001992 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 300267001993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267001994 putative substrate translocation pore; other site 300267001995 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 300267001996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267001997 active site 300267001998 motif I; other site 300267001999 motif II; other site 300267002000 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002002 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002003 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002004 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 300267002005 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 300267002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267002007 dimer interface [polypeptide binding]; other site 300267002008 conserved gate region; other site 300267002009 putative PBP binding loops; other site 300267002010 ABC-ATPase subunit interface; other site 300267002011 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 300267002012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267002013 dimer interface [polypeptide binding]; other site 300267002014 conserved gate region; other site 300267002015 putative PBP binding loops; other site 300267002016 ABC-ATPase subunit interface; other site 300267002017 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 300267002018 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 300267002019 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 300267002020 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267002021 Walker A/P-loop; other site 300267002022 ATP binding site [chemical binding]; other site 300267002023 Q-loop/lid; other site 300267002024 ABC transporter signature motif; other site 300267002025 Walker B; other site 300267002026 D-loop; other site 300267002027 H-loop/switch region; other site 300267002028 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267002029 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267002030 Walker A/P-loop; other site 300267002031 ATP binding site [chemical binding]; other site 300267002032 Q-loop/lid; other site 300267002033 ABC transporter signature motif; other site 300267002034 Walker B; other site 300267002035 D-loop; other site 300267002036 H-loop/switch region; other site 300267002037 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 300267002038 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 300267002039 catalytic nucleophile [active] 300267002040 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 300267002041 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 300267002042 dimer interface [polypeptide binding]; other site 300267002043 putative functional site; other site 300267002044 putative MPT binding site; other site 300267002045 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 300267002046 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 300267002047 ATP binding site [chemical binding]; other site 300267002048 substrate interface [chemical binding]; other site 300267002049 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 300267002050 active site 300267002051 intersubunit interactions; other site 300267002052 catalytic residue [active] 300267002053 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 300267002054 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 300267002055 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 300267002056 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 300267002057 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 300267002058 dimer interface [polypeptide binding]; other site 300267002059 active site 300267002060 glycine loop; other site 300267002061 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 300267002062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267002063 active site 300267002064 motif I; other site 300267002065 motif II; other site 300267002066 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002068 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002069 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267002071 non-specific DNA binding site [nucleotide binding]; other site 300267002072 salt bridge; other site 300267002073 sequence-specific DNA binding site [nucleotide binding]; other site 300267002074 HTH-like domain; Region: HTH_21; pfam13276 300267002075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002076 Integrase core domain; Region: rve; pfam00665 300267002077 Integrase core domain; Region: rve_3; pfam13683 300267002078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002079 Transposase; Region: HTH_Tnp_1; pfam01527 300267002080 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 300267002081 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 300267002082 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 300267002083 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 300267002084 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 300267002085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267002086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267002087 Walker A/P-loop; other site 300267002088 ATP binding site [chemical binding]; other site 300267002089 ABC transporter signature motif; other site 300267002090 Walker B; other site 300267002091 ABC transporter; Region: ABC_tran_2; pfam12848 300267002092 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267002093 L,D-transpeptidase; Provisional; Region: PRK10260 300267002094 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 300267002095 manganese transport regulator MntR; Provisional; Region: PRK11050 300267002096 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 300267002097 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 300267002098 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 300267002099 Sulfatase; Region: Sulfatase; pfam00884 300267002100 outer membrane protein X; Provisional; Region: ompX; PRK09408 300267002101 Ferritin-like domain; Region: Ferritin; pfam00210 300267002102 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 300267002103 dimerization interface [polypeptide binding]; other site 300267002104 DPS ferroxidase diiron center [ion binding]; other site 300267002105 ion pore; other site 300267002106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002107 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002108 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002109 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 300267002110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267002111 substrate binding pocket [chemical binding]; other site 300267002112 membrane-bound complex binding site; other site 300267002113 hinge residues; other site 300267002114 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 300267002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267002116 dimer interface [polypeptide binding]; other site 300267002117 conserved gate region; other site 300267002118 putative PBP binding loops; other site 300267002119 ABC-ATPase subunit interface; other site 300267002120 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 300267002121 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 300267002122 Walker A/P-loop; other site 300267002123 ATP binding site [chemical binding]; other site 300267002124 Q-loop/lid; other site 300267002125 ABC transporter signature motif; other site 300267002126 Walker B; other site 300267002127 D-loop; other site 300267002128 H-loop/switch region; other site 300267002129 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002131 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002132 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002133 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 300267002134 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 300267002135 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 300267002136 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267002137 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267002138 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267002139 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 300267002140 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267002141 ligand-binding site [chemical binding]; other site 300267002142 Uncharacterized iron-regulated protein [Function unknown]; Region: PiuC; COG3128 300267002143 hypothetical protein; Provisional; Region: PRK11019 300267002144 hypothetical protein; Provisional; Region: PRK10259 300267002145 putative dehydrogenase; Provisional; Region: PRK10098 300267002146 glycosyl transferase family protein; Provisional; Region: PRK08136 300267002147 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 300267002148 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 300267002149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 300267002150 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 300267002151 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002153 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002154 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002156 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002157 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002158 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002159 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 300267002160 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 300267002161 ATP binding site [chemical binding]; other site 300267002162 Mg++ binding site [ion binding]; other site 300267002163 motif III; other site 300267002164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267002165 nucleotide binding region [chemical binding]; other site 300267002166 ATP-binding site [chemical binding]; other site 300267002167 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 300267002168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267002169 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 300267002170 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 300267002171 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 300267002172 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267002173 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 300267002174 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 300267002175 Walker A/P-loop; other site 300267002176 ATP binding site [chemical binding]; other site 300267002177 Q-loop/lid; other site 300267002178 ABC transporter signature motif; other site 300267002179 Walker B; other site 300267002180 D-loop; other site 300267002181 H-loop/switch region; other site 300267002182 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 300267002183 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 300267002184 Walker A/P-loop; other site 300267002185 ATP binding site [chemical binding]; other site 300267002186 Q-loop/lid; other site 300267002187 ABC transporter signature motif; other site 300267002188 Walker B; other site 300267002189 D-loop; other site 300267002190 H-loop/switch region; other site 300267002191 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 300267002192 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 300267002193 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 300267002194 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 300267002195 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 300267002196 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 300267002197 putative catalytic site [active] 300267002198 putative metal binding site [ion binding]; other site 300267002199 putative phosphate binding site [ion binding]; other site 300267002200 cardiolipin synthase 2; Provisional; Region: PRK11263 300267002201 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 300267002202 putative active site [active] 300267002203 catalytic site [active] 300267002204 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 300267002205 putative active site [active] 300267002206 catalytic site [active] 300267002207 Predicted integral membrane protein [Function unknown]; Region: COG0392 300267002208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002209 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002210 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002211 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 300267002212 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002214 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002215 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002216 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267002217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002218 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267002219 HTH-like domain; Region: HTH_21; pfam13276 300267002220 Integrase core domain; Region: rve; pfam00665 300267002221 Integrase core domain; Region: rve_3; pfam13683 300267002222 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 300267002223 MoaE homodimer interface [polypeptide binding]; other site 300267002224 MoaD interaction [polypeptide binding]; other site 300267002225 active site residues [active] 300267002226 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 300267002227 MoaE interaction surface [polypeptide binding]; other site 300267002228 MoeB interaction surface [polypeptide binding]; other site 300267002229 thiocarboxylated glycine; other site 300267002230 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 300267002231 trimer interface [polypeptide binding]; other site 300267002232 dimer interface [polypeptide binding]; other site 300267002233 putative active site [active] 300267002234 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 300267002235 MPT binding site; other site 300267002236 trimer interface [polypeptide binding]; other site 300267002237 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 300267002238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267002239 FeS/SAM binding site; other site 300267002240 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 300267002241 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 300267002242 phosphate binding site [ion binding]; other site 300267002243 putative substrate binding pocket [chemical binding]; other site 300267002244 dimer interface [polypeptide binding]; other site 300267002245 excinuclease ABC subunit B; Provisional; Region: PRK05298 300267002246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267002247 ATP binding site [chemical binding]; other site 300267002248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267002249 nucleotide binding region [chemical binding]; other site 300267002250 ATP-binding site [chemical binding]; other site 300267002251 Ultra-violet resistance protein B; Region: UvrB; pfam12344 300267002252 UvrB/uvrC motif; Region: UVR; pfam02151 300267002253 AAA domain; Region: AAA_26; pfam13500 300267002254 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 300267002255 active site 300267002256 ADP binding site [chemical binding]; other site 300267002257 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 300267002258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267002259 S-adenosylmethionine binding site [chemical binding]; other site 300267002260 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 300267002261 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 300267002262 substrate-cofactor binding pocket; other site 300267002263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267002264 catalytic residue [active] 300267002265 biotin synthase; Provisional; Region: PRK15108 300267002266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267002267 FeS/SAM binding site; other site 300267002268 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 300267002269 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 300267002270 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 300267002271 inhibitor-cofactor binding pocket; inhibition site 300267002272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267002273 catalytic residue [active] 300267002274 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 300267002275 substrate binding site [chemical binding]; other site 300267002276 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267002277 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 300267002278 Leucine rich repeat; Region: LRR_8; pfam13855 300267002279 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267002280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002281 Transposase; Region: HTH_Tnp_1; pfam01527 300267002282 HTH-like domain; Region: HTH_21; pfam13276 300267002283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002284 Integrase core domain; Region: rve; pfam00665 300267002285 Integrase core domain; Region: rve_3; pfam13683 300267002286 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 300267002287 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 300267002288 putative C-terminal domain interface [polypeptide binding]; other site 300267002289 putative GSH binding site (G-site) [chemical binding]; other site 300267002290 putative dimer interface [polypeptide binding]; other site 300267002291 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 300267002292 N-terminal domain interface [polypeptide binding]; other site 300267002293 dimer interface [polypeptide binding]; other site 300267002294 substrate binding pocket (H-site) [chemical binding]; other site 300267002295 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002297 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002298 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002299 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 300267002300 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 300267002301 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 300267002302 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 300267002303 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 300267002304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267002305 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 300267002306 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 300267002307 active site 300267002308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002309 Transposase; Region: HTH_Tnp_1; cl17663 300267002310 putative transposase OrfB; Reviewed; Region: PHA02517 300267002311 HTH-like domain; Region: HTH_21; pfam13276 300267002312 Integrase core domain; Region: rve; pfam00665 300267002313 Integrase core domain; Region: rve_3; pfam13683 300267002314 HTH-like domain; Region: HTH_21; pfam13276 300267002315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002316 Integrase core domain; Region: rve; pfam00665 300267002317 Integrase core domain; Region: rve_3; pfam13683 300267002318 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 300267002319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002320 Transposase; Region: HTH_Tnp_1; pfam01527 300267002321 HTH-like domain; Region: HTH_21; pfam13276 300267002322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002323 Integrase core domain; Region: rve; pfam00665 300267002324 Integrase core domain; Region: rve_3; pfam13683 300267002325 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 300267002326 MG2 domain; Region: A2M_N; pfam01835 300267002327 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 300267002328 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 300267002329 Alpha-2-macroglobulin family; Region: A2M; pfam00207 300267002330 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 300267002331 Predicted secreted protein [Function unknown]; Region: COG5445 300267002332 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 300267002333 Predicted secreted protein [Function unknown]; Region: COG5445 300267002334 Stage II sporulation protein; Region: SpoIID; pfam08486 300267002335 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 300267002336 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 300267002337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267002338 dimer interface [polypeptide binding]; other site 300267002339 phosphorylation site [posttranslational modification] 300267002340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267002341 ATP binding site [chemical binding]; other site 300267002342 Mg2+ binding site [ion binding]; other site 300267002343 G-X-G motif; other site 300267002344 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 300267002345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267002346 active site 300267002347 phosphorylation site [posttranslational modification] 300267002348 intermolecular recognition site; other site 300267002349 dimerization interface [polypeptide binding]; other site 300267002350 transcriptional regulator RcsB; Provisional; Region: PRK10840 300267002351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267002352 active site 300267002353 phosphorylation site [posttranslational modification] 300267002354 intermolecular recognition site; other site 300267002355 dimerization interface [polypeptide binding]; other site 300267002356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267002357 DNA binding residues [nucleotide binding] 300267002358 dimerization interface [polypeptide binding]; other site 300267002359 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 300267002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267002361 ATP binding site [chemical binding]; other site 300267002362 Mg2+ binding site [ion binding]; other site 300267002363 G-X-G motif; other site 300267002364 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 300267002365 putative binding surface; other site 300267002366 active site 300267002367 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002369 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002370 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002371 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 300267002372 trimer interface [polypeptide binding]; other site 300267002373 eyelet of channel; other site 300267002374 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 300267002375 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 300267002376 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 300267002377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267002378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267002379 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 300267002380 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 300267002381 DNA binding site [nucleotide binding] 300267002382 active site 300267002383 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 300267002384 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 300267002385 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 300267002386 Walker A/P-loop; other site 300267002387 ATP binding site [chemical binding]; other site 300267002388 Q-loop/lid; other site 300267002389 ABC transporter signature motif; other site 300267002390 Walker B; other site 300267002391 D-loop; other site 300267002392 H-loop/switch region; other site 300267002393 malate:quinone oxidoreductase; Validated; Region: PRK05257 300267002394 Predicted dehydrogenase [General function prediction only]; Region: COG0579 300267002395 HTH-like domain; Region: HTH_21; pfam13276 300267002396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002397 Integrase core domain; Region: rve; pfam00665 300267002398 Integrase core domain; Region: rve_3; pfam13683 300267002399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002400 Transposase; Region: HTH_Tnp_1; pfam01527 300267002401 ferredoxin-type protein; Provisional; Region: PRK10194 300267002402 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267002403 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 300267002404 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 300267002405 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 300267002406 [4Fe-4S] binding site [ion binding]; other site 300267002407 molybdopterin cofactor binding site; other site 300267002408 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 300267002409 molybdopterin cofactor binding site; other site 300267002410 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 300267002411 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267002412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267002413 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267002414 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 300267002415 4Fe-4S binding domain; Region: Fer4_5; pfam12801 300267002416 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267002417 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 300267002418 cytochrome c-type protein NapC; Provisional; Region: PRK10617 300267002419 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 300267002420 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 300267002421 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 300267002422 Walker A/P-loop; other site 300267002423 ATP binding site [chemical binding]; other site 300267002424 Q-loop/lid; other site 300267002425 ABC transporter signature motif; other site 300267002426 Walker B; other site 300267002427 D-loop; other site 300267002428 H-loop/switch region; other site 300267002429 heme exporter protein CcmB; Region: ccmB; TIGR01190 300267002430 heme exporter protein CcmC; Region: ccmC; TIGR01191 300267002431 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 300267002432 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 300267002433 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 300267002434 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 300267002435 catalytic residues [active] 300267002436 central insert; other site 300267002437 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 300267002438 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 300267002439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 300267002440 binding surface 300267002441 TPR motif; other site 300267002442 transcriptional regulator NarP; Provisional; Region: PRK10403 300267002443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267002444 active site 300267002445 phosphorylation site [posttranslational modification] 300267002446 intermolecular recognition site; other site 300267002447 dimerization interface [polypeptide binding]; other site 300267002448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267002449 DNA binding residues [nucleotide binding] 300267002450 dimerization interface [polypeptide binding]; other site 300267002451 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002453 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002454 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002456 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002457 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002458 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 300267002459 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 300267002460 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 300267002461 Autotransporter beta-domain; Region: Autotransporter; pfam03797 300267002462 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 300267002463 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 300267002464 Sulfatase; Region: Sulfatase; pfam00884 300267002465 hypothetical protein; Provisional; Region: PRK13689 300267002466 nucleoid-associated protein NdpA; Validated; Region: PRK00378 300267002467 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 300267002468 5S rRNA interface [nucleotide binding]; other site 300267002469 CTC domain interface [polypeptide binding]; other site 300267002470 L16 interface [polypeptide binding]; other site 300267002471 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 300267002472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267002473 ATP binding site [chemical binding]; other site 300267002474 putative Mg++ binding site [ion binding]; other site 300267002475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267002476 nucleotide binding region [chemical binding]; other site 300267002477 ATP-binding site [chemical binding]; other site 300267002478 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 300267002479 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 300267002480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267002481 RNA binding surface [nucleotide binding]; other site 300267002482 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 300267002483 active site 300267002484 uracil binding [chemical binding]; other site 300267002485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267002486 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 300267002487 putative substrate translocation pore; other site 300267002488 hypothetical protein; Provisional; Region: PRK11835 300267002489 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 300267002490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267002491 Walker A/P-loop; other site 300267002492 ATP binding site [chemical binding]; other site 300267002493 Q-loop/lid; other site 300267002494 ABC transporter signature motif; other site 300267002495 Walker B; other site 300267002496 D-loop; other site 300267002497 H-loop/switch region; other site 300267002498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267002499 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267002500 Walker A/P-loop; other site 300267002501 ATP binding site [chemical binding]; other site 300267002502 Q-loop/lid; other site 300267002503 ABC transporter signature motif; other site 300267002504 Walker B; other site 300267002505 D-loop; other site 300267002506 H-loop/switch region; other site 300267002507 microcin C ABC transporter permease; Provisional; Region: PRK15021 300267002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267002509 dimer interface [polypeptide binding]; other site 300267002510 conserved gate region; other site 300267002511 putative PBP binding loops; other site 300267002512 ABC-ATPase subunit interface; other site 300267002513 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 300267002514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267002515 dimer interface [polypeptide binding]; other site 300267002516 conserved gate region; other site 300267002517 putative PBP binding loops; other site 300267002518 ABC-ATPase subunit interface; other site 300267002519 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 300267002520 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 300267002521 phage resistance protein; Provisional; Region: PRK10551 300267002522 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 300267002523 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 300267002524 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 300267002525 NlpC/P60 family; Region: NLPC_P60; pfam00877 300267002526 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 300267002527 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 300267002528 active site 300267002529 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 300267002530 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 300267002531 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 300267002532 elongation factor P; Provisional; Region: PRK04542 300267002533 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 300267002534 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 300267002535 RNA binding site [nucleotide binding]; other site 300267002536 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 300267002537 RNA binding site [nucleotide binding]; other site 300267002538 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 300267002539 sugar efflux transporter B; Provisional; Region: PRK15011 300267002540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267002541 putative substrate translocation pore; other site 300267002542 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002544 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002545 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002546 Outer membrane usher protein; Region: Usher; pfam00577 300267002547 PapC C-terminal domain; Region: PapC_C; pfam13953 300267002548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002549 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002550 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002551 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002552 Fimbrial protein; Region: Fimbrial; cl01416 300267002553 Fimbrial protein; Region: Fimbrial; cl01416 300267002554 Fimbrial protein; Region: Fimbrial; cl01416 300267002555 putativi pili assembly chaperone; Provisional; Region: PRK11385 300267002556 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 300267002557 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 300267002558 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 300267002559 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 300267002560 quinone interaction residues [chemical binding]; other site 300267002561 active site 300267002562 catalytic residues [active] 300267002563 FMN binding site [chemical binding]; other site 300267002564 substrate binding site [chemical binding]; other site 300267002565 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 300267002566 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 300267002567 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 300267002568 MOSC domain; Region: MOSC; pfam03473 300267002569 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 300267002570 catalytic loop [active] 300267002571 iron binding site [ion binding]; other site 300267002572 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 300267002573 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 300267002574 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 300267002575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267002576 S-adenosylmethionine binding site [chemical binding]; other site 300267002577 ABC transporter ATPase component; Reviewed; Region: PRK11147 300267002578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267002579 ABC transporter; Region: ABC_tran_2; pfam12848 300267002580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267002581 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 300267002582 Paraquat-inducible protein A; Region: PqiA; pfam04403 300267002583 Paraquat-inducible protein A; Region: PqiA; pfam04403 300267002584 paraquat-inducible protein B; Provisional; Region: PRK10807 300267002585 mce related protein; Region: MCE; pfam02470 300267002586 mce related protein; Region: MCE; pfam02470 300267002587 mce related protein; Region: MCE; pfam02470 300267002588 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 300267002589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 300267002590 ribosome modulation factor; Provisional; Region: PRK14563 300267002591 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 300267002592 active site 1 [active] 300267002593 dimer interface [polypeptide binding]; other site 300267002594 active site 2 [active] 300267002595 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 300267002596 outer membrane protein A; Reviewed; Region: PRK10808 300267002597 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 300267002598 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 300267002599 ligand binding site [chemical binding]; other site 300267002600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002601 Transposase; Region: HTH_Tnp_1; pfam01527 300267002602 HTH-like domain; Region: HTH_21; pfam13276 300267002603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002604 Integrase core domain; Region: rve; pfam00665 300267002605 Integrase core domain; Region: rve_3; pfam13683 300267002606 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 300267002607 TfoX C-terminal domain; Region: TfoX_C; pfam04994 300267002608 TIGR01666 family membrane protein; Region: YCCS 300267002609 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 300267002610 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 300267002611 Predicted membrane protein [Function unknown]; Region: COG3304 300267002612 Domain of unknown function (DUF307); Region: DUF307; pfam03733 300267002613 Domain of unknown function (DUF307); Region: DUF307; pfam03733 300267002614 DNA helicase IV; Provisional; Region: helD; PRK11054 300267002615 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 300267002616 Part of AAA domain; Region: AAA_19; pfam13245 300267002617 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 300267002618 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 300267002619 active site 300267002620 dimer interfaces [polypeptide binding]; other site 300267002621 catalytic residues [active] 300267002622 hypothetical protein; Provisional; Region: PRK03641 300267002623 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 300267002624 heat shock protein HspQ; Provisional; Region: PRK14129 300267002625 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 300267002626 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 300267002627 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 300267002628 putative RNA binding site [nucleotide binding]; other site 300267002629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267002630 S-adenosylmethionine binding site [chemical binding]; other site 300267002631 Acylphosphatase; Region: Acylphosphatase; cl00551 300267002632 sulfur transfer protein TusE; Provisional; Region: PRK11508 300267002633 YccA-like proteins; Region: YccA_like; cd10433 300267002634 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 300267002635 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 300267002636 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 300267002637 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 300267002638 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 300267002639 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 300267002640 putative substrate-binding site; other site 300267002641 nickel binding site [ion binding]; other site 300267002642 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 300267002643 original product: nickel incorporation into hydrogenase-1 proteins 300267002644 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 300267002645 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 300267002646 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 300267002647 hypothetical protein; Provisional; Region: PRK14749 300267002648 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 300267002649 catalytic core [active] 300267002650 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 300267002651 Chain length determinant protein; Region: Wzz; pfam02706 300267002652 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 300267002653 AAA domain; Region: AAA_31; pfam13614 300267002654 Low molecular weight phosphatase family; Region: LMWPc; cd00115 300267002655 active site 300267002656 polysaccharide export protein Wza; Provisional; Region: PRK15078 300267002657 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 300267002658 SLBB domain; Region: SLBB; pfam10531 300267002659 SLBB domain; Region: SLBB; pfam10531 300267002660 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 300267002661 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 300267002662 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 300267002663 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 300267002664 DNA-binding site [nucleotide binding]; DNA binding site 300267002665 RNA-binding motif; other site 300267002666 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002668 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002669 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002670 4Fe-4S binding domain; Region: Fer4_5; pfam12801 300267002671 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 300267002672 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 300267002673 putative ligand binding site [chemical binding]; other site 300267002674 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 300267002675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267002676 active site 300267002677 phosphorylation site [posttranslational modification] 300267002678 intermolecular recognition site; other site 300267002679 dimerization interface [polypeptide binding]; other site 300267002680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267002681 DNA binding site [nucleotide binding] 300267002682 chaperone protein TorD; Validated; Region: torD; PRK04976 300267002683 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 300267002684 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 300267002685 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 300267002686 HSP70 interaction site [polypeptide binding]; other site 300267002687 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 300267002688 substrate binding site [polypeptide binding]; other site 300267002689 dimer interface [polypeptide binding]; other site 300267002690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002691 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002692 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002693 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002694 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002695 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 300267002696 catalytic core [active] 300267002697 hypothetical protein; Provisional; Region: PRK10174 300267002698 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 300267002699 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 300267002700 General stress protein [General function prediction only]; Region: GsiB; COG3729 300267002701 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 300267002702 uracil-xanthine permease; Region: ncs2; TIGR00801 300267002703 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 300267002704 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 300267002705 putative FMN binding site [chemical binding]; other site 300267002706 pyrimidine utilization protein D; Region: RutD; TIGR03611 300267002707 Putative lysophospholipase; Region: Hydrolase_4; cl19140 300267002708 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 300267002709 homotrimer interaction site [polypeptide binding]; other site 300267002710 putative active site [active] 300267002711 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 300267002712 active site 300267002713 dimer interface [polypeptide binding]; other site 300267002714 non-prolyl cis peptide bond; other site 300267002715 insertion regions; other site 300267002716 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 300267002717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267002718 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 300267002719 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 300267002720 Na binding site [ion binding]; other site 300267002721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002722 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002723 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002724 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002726 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002727 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002728 curli assembly protein CsgE; Provisional; Region: PRK10386 300267002729 curli assembly protein CsgF; Provisional; Region: PRK10050 300267002730 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 300267002731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002732 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002733 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002734 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002735 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 300267002736 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 300267002737 putative hydrolase; Validated; Region: PRK09248 300267002738 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 300267002739 active site 300267002740 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 300267002741 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 300267002742 putative ligand binding site [chemical binding]; other site 300267002743 NAD binding site [chemical binding]; other site 300267002744 dimerization interface [polypeptide binding]; other site 300267002745 catalytic site [active] 300267002746 Methyltransferase domain; Region: Methyltransf_27; pfam13708 300267002747 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 300267002748 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 300267002749 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 300267002750 Protein of unknown function (DUF987); Region: DUF987; pfam06174 300267002751 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 300267002752 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 300267002753 MPN+ (JAMM) motif; other site 300267002754 Zinc-binding site [ion binding]; other site 300267002755 Antirestriction protein; Region: Antirestrict; pfam03230 300267002756 Domain of unknown function (DUF932); Region: DUF932; pfam06067 300267002757 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 300267002758 HTH-like domain; Region: HTH_21; pfam13276 300267002759 Integrase core domain; Region: rve; pfam00665 300267002760 Integrase core domain; Region: rve_3; pfam13683 300267002761 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267002762 HTH-like domain; Region: HTH_21; pfam13276 300267002763 Integrase core domain; Region: rve; pfam00665 300267002764 Integrase core domain; Region: rve_3; pfam13683 300267002765 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267002766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002767 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002769 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002770 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002771 outer membrane receptor FepA; Provisional; Region: PRK13528 300267002772 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267002773 N-terminal plug; other site 300267002774 ligand-binding site [chemical binding]; other site 300267002775 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 300267002776 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 300267002777 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 300267002778 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 300267002779 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267002780 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 300267002781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267002782 Walker A/P-loop; other site 300267002783 ATP binding site [chemical binding]; other site 300267002784 Q-loop/lid; other site 300267002785 ABC transporter signature motif; other site 300267002786 Walker B; other site 300267002787 D-loop; other site 300267002788 H-loop/switch region; other site 300267002789 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 300267002790 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267002791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267002792 Walker A/P-loop; other site 300267002793 ATP binding site [chemical binding]; other site 300267002794 Q-loop/lid; other site 300267002795 ABC transporter signature motif; other site 300267002796 Walker B; other site 300267002797 D-loop; other site 300267002798 H-loop/switch region; other site 300267002799 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 300267002800 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 300267002801 homodimer interface [polypeptide binding]; other site 300267002802 active site 300267002803 TDP-binding site; other site 300267002804 acceptor substrate-binding pocket; other site 300267002805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002806 Transposase; Region: HTH_Tnp_1; cl17663 300267002807 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002809 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002810 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002811 zinc/cadmium-binding protein; Provisional; Region: PRK10306 300267002812 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 300267002813 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 300267002814 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 300267002815 Moco binding site; other site 300267002816 metal coordination site [ion binding]; other site 300267002817 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002819 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002820 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002821 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 300267002822 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 300267002823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267002824 active site 300267002825 phosphorylation site [posttranslational modification] 300267002826 intermolecular recognition site; other site 300267002827 dimerization interface [polypeptide binding]; other site 300267002828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267002829 DNA binding site [nucleotide binding] 300267002830 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002832 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002833 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002834 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 300267002835 DNA cytosine methylase; Provisional; Region: PRK10458 300267002836 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 300267002837 cofactor binding site; other site 300267002838 DNA binding site [nucleotide binding] 300267002839 substrate interaction site [chemical binding]; other site 300267002840 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 300267002841 additional DNA contacts [nucleotide binding]; other site 300267002842 mismatch recognition site; other site 300267002843 active site 300267002844 zinc binding site [ion binding]; other site 300267002845 DNA intercalation site [nucleotide binding]; other site 300267002846 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 300267002847 EamA-like transporter family; Region: EamA; pfam00892 300267002848 EamA-like transporter family; Region: EamA; pfam00892 300267002849 hypothetical protein; Provisional; Region: PRK10062 300267002850 Uncharacterized small protein [Function unknown]; Region: COG5475 300267002851 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 300267002852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267002853 metal binding site [ion binding]; metal-binding site 300267002854 active site 300267002855 I-site; other site 300267002856 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 300267002857 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 300267002858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267002859 active site 300267002860 motif I; other site 300267002861 motif II; other site 300267002862 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 300267002863 hypothetical protein; Provisional; Region: PRK10708 300267002864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002865 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002866 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002867 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002868 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002870 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002871 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002872 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002874 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002875 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002876 Methyltransferase domain; Region: Methyltransf_31; pfam13847 300267002877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267002878 S-adenosylmethionine binding site [chemical binding]; other site 300267002879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002880 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002881 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002882 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002883 HTH-like domain; Region: HTH_21; pfam13276 300267002884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002885 Integrase core domain; Region: rve; pfam00665 300267002886 Integrase core domain; Region: rve_3; pfam13683 300267002887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002888 Transposase; Region: HTH_Tnp_1; pfam01527 300267002889 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 300267002890 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 300267002891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002892 Transposase; Region: HTH_Tnp_1; pfam01527 300267002893 HTH-like domain; Region: HTH_21; pfam13276 300267002894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267002895 Integrase core domain; Region: rve; pfam00665 300267002896 Integrase core domain; Region: rve_3; pfam13683 300267002897 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002898 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002899 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002900 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002901 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 300267002902 Lysin motif; Region: LysM; smart00257 300267002903 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 300267002904 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 300267002905 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 300267002906 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267002907 HTH-like domain; Region: HTH_21; pfam13276 300267002908 Integrase core domain; Region: rve; pfam00665 300267002909 Integrase core domain; Region: rve_3; pfam13683 300267002910 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267002911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267002912 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002914 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002915 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002916 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002918 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002919 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002920 hypothetical protein; Provisional; Region: PRK09951 300267002921 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 300267002922 CPxP motif; other site 300267002923 putative inner membrane protein; Provisional; Region: PRK11099 300267002924 Predicted transporter component [General function prediction only]; Region: COG2391 300267002925 lipoprotein; Provisional; Region: PRK10397 300267002926 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 300267002927 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 300267002928 active site 300267002929 Na/Ca binding site [ion binding]; other site 300267002930 catalytic site [active] 300267002931 Flagellar protein FliS; Region: FliS; cl00654 300267002932 flagellar capping protein; Reviewed; Region: fliD; PRK08032 300267002933 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 300267002934 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 300267002935 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267002936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002937 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002938 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002939 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 300267002940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 300267002941 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 300267002942 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 300267002943 DNA binding residues [nucleotide binding] 300267002944 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 300267002945 cystine transporter subunit; Provisional; Region: PRK11260 300267002946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267002947 substrate binding pocket [chemical binding]; other site 300267002948 membrane-bound complex binding site; other site 300267002949 hinge residues; other site 300267002950 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 300267002951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267002952 catalytic residue [active] 300267002953 amino acid ABC transporter permease; Provisional; Region: PRK15100 300267002954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267002955 dimer interface [polypeptide binding]; other site 300267002956 conserved gate region; other site 300267002957 putative PBP binding loops; other site 300267002958 ABC-ATPase subunit interface; other site 300267002959 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 300267002960 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 300267002961 Walker A/P-loop; other site 300267002962 ATP binding site [chemical binding]; other site 300267002963 Q-loop/lid; other site 300267002964 ABC transporter signature motif; other site 300267002965 Walker B; other site 300267002966 D-loop; other site 300267002967 H-loop/switch region; other site 300267002968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267002969 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267002970 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267002971 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267002972 hypothetical protein; Provisional; Region: PRK10613 300267002973 response regulator; Provisional; Region: PRK09483 300267002974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267002975 active site 300267002976 phosphorylation site [posttranslational modification] 300267002977 intermolecular recognition site; other site 300267002978 dimerization interface [polypeptide binding]; other site 300267002979 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267002980 DNA binding residues [nucleotide binding] 300267002981 dimerization interface [polypeptide binding]; other site 300267002982 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 300267002983 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 300267002984 GIY-YIG motif/motif A; other site 300267002985 active site 300267002986 catalytic site [active] 300267002987 putative DNA binding site [nucleotide binding]; other site 300267002988 metal binding site [ion binding]; metal-binding site 300267002989 UvrB/uvrC motif; Region: UVR; pfam02151 300267002990 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 300267002991 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 300267002992 hypothetical protein; Provisional; Region: PRK10396 300267002993 yecA family protein; Region: ygfB_yecA; TIGR02292 300267002994 SEC-C motif; Region: SEC-C; cl19389 300267002995 tyrosine transporter TyrP; Provisional; Region: PRK15132 300267002996 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 300267002997 probable metal-binding protein; Region: matur_matur; TIGR03853 300267002998 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 300267002999 Ferritin-like domain; Region: Ferritin; pfam00210 300267003000 ferroxidase diiron center [ion binding]; other site 300267003001 YecR-like lipoprotein; Region: YecR; pfam13992 300267003002 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003004 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003005 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003006 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 300267003007 Ferritin-like domain; Region: Ferritin; pfam00210 300267003008 ferroxidase diiron center [ion binding]; other site 300267003009 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 300267003010 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003011 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 300267003012 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 300267003013 ligand binding site [chemical binding]; other site 300267003014 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 300267003015 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 300267003016 Walker A/P-loop; other site 300267003017 ATP binding site [chemical binding]; other site 300267003018 Q-loop/lid; other site 300267003019 ABC transporter signature motif; other site 300267003020 Walker B; other site 300267003021 D-loop; other site 300267003022 H-loop/switch region; other site 300267003023 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 300267003024 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 300267003025 TM-ABC transporter signature motif; other site 300267003026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003027 Transposase; Region: HTH_Tnp_1; pfam01527 300267003028 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 300267003029 hypothetical protein; Provisional; Region: PRK10301 300267003030 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 300267003031 Predicted amidohydrolase [General function prediction only]; Region: COG0388 300267003032 exodeoxyribonuclease X; Provisional; Region: PRK07983 300267003033 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 300267003034 active site 300267003035 catalytic site [active] 300267003036 substrate binding site [chemical binding]; other site 300267003037 protease 2; Provisional; Region: PRK10115 300267003038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 300267003039 Protein of unknown function (DUF533); Region: DUF533; pfam04391 300267003040 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 300267003041 putative metal binding site [ion binding]; other site 300267003042 hypothetical protein; Provisional; Region: PRK13680 300267003043 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 300267003044 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 300267003045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 300267003046 ATP-grasp domain; Region: ATP-grasp; pfam02222 300267003047 Entner-Doudoroff aldolase; Region: eda; TIGR01182 300267003048 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 300267003049 active site 300267003050 intersubunit interface [polypeptide binding]; other site 300267003051 catalytic residue [active] 300267003052 phosphogluconate dehydratase; Validated; Region: PRK09054 300267003053 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 300267003054 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 300267003055 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 300267003056 pyruvate kinase; Provisional; Region: PRK05826 300267003057 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 300267003058 domain interfaces; other site 300267003059 active site 300267003060 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 300267003061 putative acyl-acceptor binding pocket; other site 300267003062 putative peptidase; Provisional; Region: PRK11649 300267003063 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 300267003064 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 300267003065 Peptidase family M23; Region: Peptidase_M23; pfam01551 300267003066 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 300267003067 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 300267003068 metal binding site [ion binding]; metal-binding site 300267003069 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 300267003070 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 300267003071 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267003072 ABC-ATPase subunit interface; other site 300267003073 dimer interface [polypeptide binding]; other site 300267003074 putative PBP binding regions; other site 300267003075 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 300267003076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267003077 Walker A motif; other site 300267003078 ATP binding site [chemical binding]; other site 300267003079 Walker B motif; other site 300267003080 arginine finger; other site 300267003081 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 300267003082 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 300267003083 RuvA N terminal domain; Region: RuvA_N; pfam01330 300267003084 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 300267003085 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 300267003086 hypothetical protein; Provisional; Region: PRK11470 300267003087 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 300267003088 active site 300267003089 putative DNA-binding cleft [nucleotide binding]; other site 300267003090 dimer interface [polypeptide binding]; other site 300267003091 hypothetical protein; Validated; Region: PRK00110 300267003092 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 300267003093 nudix motif; other site 300267003094 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 300267003095 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 300267003096 dimer interface [polypeptide binding]; other site 300267003097 anticodon binding site; other site 300267003098 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 300267003099 homodimer interface [polypeptide binding]; other site 300267003100 motif 1; other site 300267003101 active site 300267003102 motif 2; other site 300267003103 GAD domain; Region: GAD; pfam02938 300267003104 motif 3; other site 300267003105 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 300267003106 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267003107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267003108 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 300267003109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003110 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003111 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003113 Transposase; Region: HTH_Tnp_1; cl17663 300267003114 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003115 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267003116 HTH-like domain; Region: HTH_21; pfam13276 300267003117 Integrase core domain; Region: rve; pfam00665 300267003118 Integrase core domain; Region: rve_3; pfam13683 300267003119 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267003120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003122 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003123 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003124 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003125 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 300267003126 Protein of unknown function DUF72; Region: DUF72; cl00777 300267003127 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 300267003128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267003129 S-adenosylmethionine binding site [chemical binding]; other site 300267003130 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 300267003131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267003132 S-adenosylmethionine binding site [chemical binding]; other site 300267003133 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 300267003134 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 300267003135 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 300267003136 molybdopterin cofactor binding site; other site 300267003137 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 300267003138 molybdopterin cofactor binding site; other site 300267003139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003140 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003141 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003142 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003144 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003145 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003146 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003148 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003149 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003150 copper homeostasis protein CutC; Provisional; Region: PRK11572 300267003151 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 300267003152 putative metal binding site [ion binding]; other site 300267003153 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 300267003154 arginyl-tRNA synthetase; Region: argS; TIGR00456 300267003155 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 300267003156 active site 300267003157 HIGH motif; other site 300267003158 KMSK motif region; other site 300267003159 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 300267003160 tRNA binding surface [nucleotide binding]; other site 300267003161 anticodon binding site; other site 300267003162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003163 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003164 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003165 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003166 Flagellar protein FlhE; Region: FlhE; pfam06366 300267003167 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003169 Transposase; Region: HTH_Tnp_1; pfam01527 300267003170 HTH-like domain; Region: HTH_21; pfam13276 300267003171 Integrase core domain; Region: rve; pfam00665 300267003172 Integrase core domain; Region: rve_3; pfam13683 300267003173 flagellar motor protein MotA; Validated; Region: PRK09110 300267003174 transcriptional activator FlhC; Provisional; Region: PRK12722 300267003175 transcriptional activator FlhD; Provisional; Region: PRK02909 300267003176 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 300267003177 Ligand Binding Site [chemical binding]; other site 300267003178 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 300267003179 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 300267003180 active site 300267003181 homotetramer interface [polypeptide binding]; other site 300267003182 putative transposase OrfB; Reviewed; Region: PHA02517 300267003183 HTH-like domain; Region: HTH_21; pfam13276 300267003184 Integrase core domain; Region: rve; pfam00665 300267003185 Integrase core domain; Region: rve_3; pfam13683 300267003186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003187 Transposase; Region: HTH_Tnp_1; cl17663 300267003188 HTH-like domain; Region: HTH_21; pfam13276 300267003189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267003190 Integrase core domain; Region: rve; pfam00665 300267003191 Integrase core domain; Region: rve_3; pfam13683 300267003192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003193 Transposase; Region: HTH_Tnp_1; pfam01527 300267003194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003195 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003196 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003197 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003199 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003200 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003201 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003202 hypothetical protein; Provisional; Region: PRK09945 300267003203 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003205 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003206 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003207 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 300267003208 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 300267003209 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 300267003210 Autotransporter beta-domain; Region: Autotransporter; pfam03797 300267003211 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 300267003212 cell division inhibitor MinD; Provisional; Region: PRK10818 300267003213 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 300267003214 P-loop; other site 300267003215 ADP binding residues [chemical binding]; other site 300267003216 Switch I; other site 300267003217 Switch II; other site 300267003218 septum formation inhibitor; Reviewed; Region: minC; PRK03511 300267003219 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 300267003220 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 300267003221 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003223 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003224 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003225 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 300267003226 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 300267003227 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 300267003228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 300267003229 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 300267003230 hypothetical protein; Provisional; Region: PRK10691 300267003231 hypothetical protein; Provisional; Region: PRK05170 300267003232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003233 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003234 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003235 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003237 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003238 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003239 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003241 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003242 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003243 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003244 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 300267003245 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 300267003246 Catalytic site [active] 300267003247 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 300267003248 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 300267003249 active site 300267003250 DNA binding site [nucleotide binding] 300267003251 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 300267003252 disulfide bond formation protein B; Provisional; Region: PRK01749 300267003253 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 300267003254 fatty acid metabolism regulator; Provisional; Region: PRK04984 300267003255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267003256 DNA-binding site [nucleotide binding]; DNA binding site 300267003257 FadR C-terminal domain; Region: FadR_C; pfam07840 300267003258 SpoVR family protein; Provisional; Region: PRK11767 300267003259 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 300267003260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267003261 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 300267003262 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 300267003263 TrkA-C domain; Region: TrkA_C; pfam02080 300267003264 Transporter associated domain; Region: CorC_HlyC; smart01091 300267003265 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 300267003266 dimer interface [polypeptide binding]; other site 300267003267 catalytic triad [active] 300267003268 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 300267003269 N-acetyl-D-glucosamine binding site [chemical binding]; other site 300267003270 catalytic residue [active] 300267003271 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 300267003272 Flagellar regulator YcgR; Region: YcgR; pfam07317 300267003273 PilZ domain; Region: PilZ; pfam07238 300267003274 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 300267003275 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 300267003276 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 300267003277 molybdenum transport protein ModD; Provisional; Region: PRK06096 300267003278 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 300267003279 dimerization interface [polypeptide binding]; other site 300267003280 active site 300267003281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003282 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003283 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003284 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267003286 S-adenosylmethionine binding site [chemical binding]; other site 300267003287 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 300267003288 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 300267003289 Walker A/P-loop; other site 300267003290 ATP binding site [chemical binding]; other site 300267003291 Q-loop/lid; other site 300267003292 ABC transporter signature motif; other site 300267003293 Walker B; other site 300267003294 D-loop; other site 300267003295 H-loop/switch region; other site 300267003296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267003297 ABC-ATPase subunit interface; other site 300267003298 dimer interface [polypeptide binding]; other site 300267003299 putative PBP binding regions; other site 300267003300 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003302 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003303 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003304 trehalase; Provisional; Region: treA; PRK13271 300267003305 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 300267003306 DAK2 domain; Region: Dak2; cl03685 300267003307 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 300267003308 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003310 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003311 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003312 GTP-binding protein YchF; Reviewed; Region: PRK09601 300267003313 YchF GTPase; Region: YchF; cd01900 300267003314 G1 box; other site 300267003315 GTP/Mg2+ binding site [chemical binding]; other site 300267003316 Switch I region; other site 300267003317 G2 box; other site 300267003318 Switch II region; other site 300267003319 G3 box; other site 300267003320 G4 box; other site 300267003321 G5 box; other site 300267003322 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 300267003323 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 300267003324 putative active site [active] 300267003325 catalytic residue [active] 300267003326 hypothetical protein; Provisional; Region: PRK10692 300267003327 putative transporter; Provisional; Region: PRK11660 300267003328 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 300267003329 Sulfate transporter family; Region: Sulfate_transp; pfam00916 300267003330 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 300267003331 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 300267003332 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 300267003333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 300267003334 active site 300267003335 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 300267003336 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 300267003337 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 300267003338 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 300267003339 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 300267003340 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 300267003341 tRNA; other site 300267003342 putative tRNA binding site [nucleotide binding]; other site 300267003343 putative NADP binding site [chemical binding]; other site 300267003344 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 300267003345 peptide chain release factor 1; Validated; Region: prfA; PRK00591 300267003346 This domain is found in peptide chain release factors; Region: PCRF; smart00937 300267003347 RF-1 domain; Region: RF-1; pfam00472 300267003348 HemK family putative methylases; Region: hemK_fam; TIGR00536 300267003349 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 300267003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267003351 S-adenosylmethionine binding site [chemical binding]; other site 300267003352 hypothetical protein; Provisional; Region: PRK10278 300267003353 hypothetical protein; Provisional; Region: PRK10941 300267003354 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 300267003355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 300267003356 TPR motif; other site 300267003357 binding surface 300267003358 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 300267003359 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 300267003360 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 300267003361 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 300267003362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003363 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003364 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003365 cation transport regulator; Reviewed; Region: chaB; PRK09582 300267003366 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 300267003367 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 300267003368 putative active site pocket [active] 300267003369 dimerization interface [polypeptide binding]; other site 300267003370 putative catalytic residue [active] 300267003371 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 300267003372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003373 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003374 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003375 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003376 transcriptional regulator NarL; Provisional; Region: PRK10651 300267003377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267003378 active site 300267003379 phosphorylation site [posttranslational modification] 300267003380 intermolecular recognition site; other site 300267003381 dimerization interface [polypeptide binding]; other site 300267003382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267003383 DNA binding residues [nucleotide binding] 300267003384 dimerization interface [polypeptide binding]; other site 300267003385 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 300267003386 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 300267003387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267003388 dimerization interface [polypeptide binding]; other site 300267003389 Histidine kinase; Region: HisKA_3; pfam07730 300267003390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267003391 ATP binding site [chemical binding]; other site 300267003392 Mg2+ binding site [ion binding]; other site 300267003393 G-X-G motif; other site 300267003394 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 300267003395 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 300267003396 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 300267003397 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 300267003398 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 300267003399 [4Fe-4S] binding site [ion binding]; other site 300267003400 molybdopterin cofactor binding site [chemical binding]; other site 300267003401 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 300267003402 molybdopterin cofactor binding site; other site 300267003403 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 300267003404 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 300267003405 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 300267003406 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 300267003407 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 300267003408 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 300267003409 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 300267003410 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 300267003411 putative active site [active] 300267003412 putative substrate binding site [chemical binding]; other site 300267003413 putative cosubstrate binding site; other site 300267003414 catalytic site [active] 300267003415 hypothetical protein; Provisional; Region: PRK01617 300267003416 SEC-C motif; Region: SEC-C; cl19389 300267003417 SEC-C motif; Region: SEC-C; cl19389 300267003418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267003419 active site 300267003420 response regulator of RpoS; Provisional; Region: PRK10693 300267003421 phosphorylation site [posttranslational modification] 300267003422 intermolecular recognition site; other site 300267003423 dimerization interface [polypeptide binding]; other site 300267003424 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 300267003425 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 300267003426 active site 300267003427 tetramer interface; other site 300267003428 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 300267003429 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 300267003430 thymidine kinase; Provisional; Region: PRK04296 300267003431 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003432 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267003433 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267003434 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267003435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003436 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003437 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003438 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 300267003439 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 300267003440 putative catalytic cysteine [active] 300267003441 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 300267003442 putative active site [active] 300267003443 metal binding site [ion binding]; metal-binding site 300267003444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003445 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003446 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003447 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003449 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003450 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003451 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003452 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003454 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003455 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003456 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 300267003457 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 300267003458 peptide binding site [polypeptide binding]; other site 300267003459 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 300267003460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267003461 dimer interface [polypeptide binding]; other site 300267003462 conserved gate region; other site 300267003463 putative PBP binding loops; other site 300267003464 ABC-ATPase subunit interface; other site 300267003465 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 300267003466 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 300267003467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267003468 dimer interface [polypeptide binding]; other site 300267003469 conserved gate region; other site 300267003470 putative PBP binding loops; other site 300267003471 ABC-ATPase subunit interface; other site 300267003472 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 300267003473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267003474 Walker A/P-loop; other site 300267003475 ATP binding site [chemical binding]; other site 300267003476 Q-loop/lid; other site 300267003477 ABC transporter signature motif; other site 300267003478 Walker B; other site 300267003479 D-loop; other site 300267003480 H-loop/switch region; other site 300267003481 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267003482 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 300267003483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267003484 Walker A/P-loop; other site 300267003485 ATP binding site [chemical binding]; other site 300267003486 Q-loop/lid; other site 300267003487 ABC transporter signature motif; other site 300267003488 Walker B; other site 300267003489 D-loop; other site 300267003490 H-loop/switch region; other site 300267003491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267003492 dsDNA-mimic protein; Reviewed; Region: PRK05094 300267003493 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 300267003494 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 300267003495 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 300267003496 putative active site [active] 300267003497 catalytic site [active] 300267003498 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 300267003499 putative active site [active] 300267003500 catalytic site [active] 300267003501 voltage-gated potassium channel; Provisional; Region: PRK10537 300267003502 Ion channel; Region: Ion_trans_2; pfam07885 300267003503 TrkA-N domain; Region: TrkA_N; pfam02254 300267003504 YciI-like protein; Reviewed; Region: PRK11370 300267003505 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267003506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003507 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267003508 HTH-like domain; Region: HTH_21; pfam13276 300267003509 Integrase core domain; Region: rve; pfam00665 300267003510 Integrase core domain; Region: rve_3; pfam13683 300267003511 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 300267003512 multiple promoter invertase; Provisional; Region: mpi; PRK13413 300267003513 catalytic residues [active] 300267003514 catalytic nucleophile [active] 300267003515 Presynaptic Site I dimer interface [polypeptide binding]; other site 300267003516 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 300267003517 Synaptic Flat tetramer interface [polypeptide binding]; other site 300267003518 Synaptic Site I dimer interface [polypeptide binding]; other site 300267003519 DNA binding site [nucleotide binding] 300267003520 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 300267003521 DNA-binding interface [nucleotide binding]; DNA binding site 300267003522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003523 Transposase; Region: HTH_Tnp_1; cl17663 300267003524 transport protein TonB; Provisional; Region: PRK10819 300267003525 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 300267003526 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 300267003527 intracellular septation protein A; Reviewed; Region: PRK00259 300267003528 hypothetical protein; Provisional; Region: PRK02868 300267003529 outer membrane protein W; Provisional; Region: PRK10959 300267003530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 300267003531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003532 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003533 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003534 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003536 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003537 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003539 Transposase; Region: HTH_Tnp_1; pfam01527 300267003540 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 300267003541 substrate binding site [chemical binding]; other site 300267003542 active site 300267003543 catalytic residues [active] 300267003544 heterodimer interface [polypeptide binding]; other site 300267003545 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 300267003546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267003547 catalytic residue [active] 300267003548 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 300267003549 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 300267003550 active site 300267003551 ribulose/triose binding site [chemical binding]; other site 300267003552 phosphate binding site [ion binding]; other site 300267003553 substrate (anthranilate) binding pocket [chemical binding]; other site 300267003554 product (indole) binding pocket [chemical binding]; other site 300267003555 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 300267003556 active site 300267003557 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 300267003558 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 300267003559 glutamine binding [chemical binding]; other site 300267003560 catalytic triad [active] 300267003561 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 300267003562 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 300267003563 anthranilate synthase component I; Provisional; Region: PRK13564 300267003564 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 300267003565 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 300267003566 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 300267003567 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 300267003568 active site 300267003569 hypothetical protein; Provisional; Region: PRK11630 300267003570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003571 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003572 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003573 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003574 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 300267003575 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 300267003576 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267003577 RNA binding surface [nucleotide binding]; other site 300267003578 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 300267003579 probable active site [active] 300267003580 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 300267003581 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 300267003582 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 300267003583 homodimer interface [polypeptide binding]; other site 300267003584 Walker A motif; other site 300267003585 ATP binding site [chemical binding]; other site 300267003586 hydroxycobalamin binding site [chemical binding]; other site 300267003587 Walker B motif; other site 300267003588 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 300267003589 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 300267003590 NADP binding site [chemical binding]; other site 300267003591 homodimer interface [polypeptide binding]; other site 300267003592 active site 300267003593 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 300267003594 putative inner membrane peptidase; Provisional; Region: PRK11778 300267003595 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 300267003596 tandem repeat interface [polypeptide binding]; other site 300267003597 oligomer interface [polypeptide binding]; other site 300267003598 active site residues [active] 300267003599 hypothetical protein; Provisional; Region: PRK11037 300267003600 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 300267003601 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 300267003602 active site 300267003603 interdomain interaction site; other site 300267003604 putative metal-binding site [ion binding]; other site 300267003605 nucleotide binding site [chemical binding]; other site 300267003606 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 300267003607 domain I; other site 300267003608 DNA binding groove [nucleotide binding] 300267003609 phosphate binding site [ion binding]; other site 300267003610 domain II; other site 300267003611 domain III; other site 300267003612 nucleotide binding site [chemical binding]; other site 300267003613 catalytic site [active] 300267003614 domain IV; other site 300267003615 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 300267003616 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 300267003617 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 300267003618 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 300267003619 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 300267003620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267003621 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 300267003622 substrate binding site [chemical binding]; other site 300267003623 putative dimerization interface [polypeptide binding]; other site 300267003624 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003626 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003627 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003629 Transposase; Region: HTH_Tnp_1; pfam01527 300267003630 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 300267003631 dimerization interface [polypeptide binding]; other site 300267003632 active site 300267003633 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 300267003634 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 300267003635 active site 300267003636 Predicted membrane protein [Function unknown]; Region: COG3771 300267003637 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 300267003638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 300267003639 TPR motif; other site 300267003640 binding surface 300267003641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 300267003642 binding surface 300267003643 TPR motif; other site 300267003644 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 300267003645 active site 300267003646 dimer interface [polypeptide binding]; other site 300267003647 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 300267003648 putative rRNA binding site [nucleotide binding]; other site 300267003649 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003651 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003652 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003653 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 300267003654 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 300267003655 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267003656 hypothetical protein; Provisional; Region: PRK13658 300267003657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003658 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003659 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003660 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003661 exoribonuclease II; Provisional; Region: PRK05054 300267003662 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 300267003663 RNB domain; Region: RNB; pfam00773 300267003664 S1 RNA binding domain; Region: S1; pfam00575 300267003665 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 300267003666 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 300267003667 NAD binding site [chemical binding]; other site 300267003668 homotetramer interface [polypeptide binding]; other site 300267003669 homodimer interface [polypeptide binding]; other site 300267003670 substrate binding site [chemical binding]; other site 300267003671 active site 300267003672 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003673 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003675 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003676 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003677 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 300267003678 MMPL family; Region: MMPL; cl14618 300267003679 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 300267003680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267003681 putative substrate translocation pore; other site 300267003682 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267003683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267003684 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 300267003685 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 300267003686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267003687 Walker A/P-loop; other site 300267003688 ATP binding site [chemical binding]; other site 300267003689 Q-loop/lid; other site 300267003690 ABC transporter signature motif; other site 300267003691 Walker B; other site 300267003692 D-loop; other site 300267003693 H-loop/switch region; other site 300267003694 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 300267003695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267003696 Walker A/P-loop; other site 300267003697 ATP binding site [chemical binding]; other site 300267003698 Q-loop/lid; other site 300267003699 ABC transporter signature motif; other site 300267003700 Walker B; other site 300267003701 D-loop; other site 300267003702 H-loop/switch region; other site 300267003703 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267003704 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 300267003705 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 300267003706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267003707 dimer interface [polypeptide binding]; other site 300267003708 conserved gate region; other site 300267003709 putative PBP binding loops; other site 300267003710 ABC-ATPase subunit interface; other site 300267003711 integrase; Provisional; Region: PRK09692 300267003712 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 300267003713 active site 300267003714 Int/Topo IB signature motif; other site 300267003715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003716 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003717 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003718 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 300267003719 phage recombination protein Bet; Region: bet_lambda; TIGR01913 300267003720 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 300267003721 exonuclease VIII; Reviewed; Region: PRK09709 300267003722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003723 Transposase; Region: HTH_Tnp_1; pfam01527 300267003724 Ribosome inactivating protein; Region: RIP; pfam00161 300267003725 Shiga-like toxin beta subunit; Region: SLT_beta; pfam02258 300267003726 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 300267003727 Domain of unknown function (DUF303); Region: DUF303; pfam03629 300267003728 Protein of unknown function (DUF826); Region: DUF826; pfam05696 300267003729 Lysis protein S; Region: Lysis_S; pfam04971 300267003730 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 300267003731 catalytic residues [active] 300267003732 putative transposase OrfB; Reviewed; Region: PHA02517 300267003733 HTH-like domain; Region: HTH_21; pfam13276 300267003734 Integrase core domain; Region: rve; pfam00665 300267003735 Integrase core domain; Region: rve_3; pfam13683 300267003736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003737 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003738 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003739 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003740 Predicted ATPase [General function prediction only]; Region: COG3106 300267003741 hypothetical protein; Provisional; Region: PRK05415 300267003742 Predicted membrane protein [Function unknown]; Region: COG3768 300267003743 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 300267003744 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 300267003745 putative aromatic amino acid binding site; other site 300267003746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 300267003747 putative active site [active] 300267003748 heme pocket [chemical binding]; other site 300267003749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267003750 Walker A motif; other site 300267003751 ATP binding site [chemical binding]; other site 300267003752 Walker B motif; other site 300267003753 arginine finger; other site 300267003754 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 300267003755 dimer interface [polypeptide binding]; other site 300267003756 catalytic triad [active] 300267003757 peroxidatic and resolving cysteines [active] 300267003758 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 300267003759 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 300267003760 active site 300267003761 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 300267003762 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 300267003763 putative active site [active] 300267003764 Zn binding site [ion binding]; other site 300267003765 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003767 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003768 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003770 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003771 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003772 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 300267003774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267003775 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 300267003776 putative effector binding pocket; other site 300267003777 putative dimerization interface [polypeptide binding]; other site 300267003778 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 300267003779 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 300267003780 peptide binding site [polypeptide binding]; other site 300267003781 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 300267003782 Mechanosensitive ion channel; Region: MS_channel; pfam00924 300267003783 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003785 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003786 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003787 universal stress protein UspE; Provisional; Region: PRK11175 300267003788 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 300267003789 Ligand Binding Site [chemical binding]; other site 300267003790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 300267003791 Ligand Binding Site [chemical binding]; other site 300267003792 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003794 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003795 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003796 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 300267003797 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 300267003798 ligand binding site [chemical binding]; other site 300267003799 flexible hinge region; other site 300267003800 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 300267003801 putative switch regulator; other site 300267003802 non-specific DNA interactions [nucleotide binding]; other site 300267003803 DNA binding site [nucleotide binding] 300267003804 sequence specific DNA binding site [nucleotide binding]; other site 300267003805 putative cAMP binding site [chemical binding]; other site 300267003806 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 300267003807 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 300267003808 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 300267003809 DNA binding site [nucleotide binding] 300267003810 active site 300267003811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003812 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003813 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003814 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 300267003816 Smr domain; Region: Smr; pfam01713 300267003817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267003818 I-site; other site 300267003819 active site 300267003820 metal binding site [ion binding]; metal-binding site 300267003821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003822 Transposase; Region: HTH_Tnp_1; pfam01527 300267003823 HTH-like domain; Region: HTH_21; pfam13276 300267003824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267003825 Integrase core domain; Region: rve; pfam00665 300267003826 Integrase core domain; Region: rve_3; pfam13683 300267003827 PAS domain S-box; Region: sensory_box; TIGR00229 300267003828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 300267003829 putative active site [active] 300267003830 heme pocket [chemical binding]; other site 300267003831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267003832 metal binding site [ion binding]; metal-binding site 300267003833 active site 300267003834 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 300267003835 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 300267003836 Cl binding site [ion binding]; other site 300267003837 oligomer interface [polypeptide binding]; other site 300267003838 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 300267003839 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 300267003840 Ligand Binding Site [chemical binding]; other site 300267003841 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 300267003842 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 300267003843 DNA binding site [nucleotide binding] 300267003844 active site 300267003845 Int/Topo IB signature motif; other site 300267003846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003847 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003848 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003850 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003851 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003852 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003853 Hok/gef family; Region: HOK_GEF; pfam01848 300267003854 Protein of unknown function (DUF968); Region: DUF968; pfam06147 300267003855 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 300267003856 Antitermination protein; Region: Antiterm; pfam03589 300267003857 Antitermination protein; Region: Antiterm; pfam03589 300267003858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003859 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003860 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003861 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003863 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003864 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003865 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003866 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 300267003867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003868 Transposase; Region: HTH_Tnp_1; pfam01527 300267003869 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003871 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003872 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003873 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 300267003874 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267003875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003876 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267003877 HTH-like domain; Region: HTH_21; pfam13276 300267003878 Integrase core domain; Region: rve; pfam00665 300267003879 Integrase core domain; Region: rve_3; pfam13683 300267003880 Lysis protein S; Region: Lysis_S; pfam04971 300267003881 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 300267003882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003883 Transposase; Region: HTH_Tnp_1; pfam01527 300267003884 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267003885 ABC-ATPase subunit interface; other site 300267003886 dimer interface [polypeptide binding]; other site 300267003887 putative PBP binding regions; other site 300267003888 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267003889 ABC-ATPase subunit interface; other site 300267003890 dimer interface [polypeptide binding]; other site 300267003891 putative PBP binding regions; other site 300267003892 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 300267003893 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 300267003894 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 300267003895 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 300267003896 metal binding site [ion binding]; metal-binding site 300267003897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 300267003898 Ligand Binding Site [chemical binding]; other site 300267003899 HTH-like domain; Region: HTH_21; pfam13276 300267003900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267003901 Integrase core domain; Region: rve; pfam00665 300267003902 Integrase core domain; Region: rve_3; pfam13683 300267003903 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 300267003904 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 300267003905 dimer interface [polypeptide binding]; other site 300267003906 PYR/PP interface [polypeptide binding]; other site 300267003907 TPP binding site [chemical binding]; other site 300267003908 substrate binding site [chemical binding]; other site 300267003909 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 300267003910 Domain of unknown function; Region: EKR; pfam10371 300267003911 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 300267003912 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 300267003913 TPP-binding site [chemical binding]; other site 300267003914 dimer interface [polypeptide binding]; other site 300267003915 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 300267003916 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 300267003917 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 300267003918 putative ligand binding site [chemical binding]; other site 300267003919 putative NAD binding site [chemical binding]; other site 300267003920 catalytic site [active] 300267003921 hypothetical protein; Provisional; Region: PRK10695 300267003922 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 300267003923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003924 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003925 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003926 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003928 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003929 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003930 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003931 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 300267003932 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 300267003933 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003935 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003936 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003937 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 300267003938 active site 300267003939 catalytic residue [active] 300267003940 dimer interface [polypeptide binding]; other site 300267003941 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 300267003942 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 300267003943 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 300267003944 shikimate binding site; other site 300267003945 NAD(P) binding site [chemical binding]; other site 300267003946 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003948 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003949 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003950 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267003951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003952 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003953 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267003955 Transposase; Region: HTH_Tnp_1; pfam01527 300267003956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003957 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003958 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267003960 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267003961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003962 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003963 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003964 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 300267003965 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 300267003966 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 300267003967 active site 300267003968 catalytic tetrad [active] 300267003969 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 300267003970 active site 300267003971 phosphate binding residues; other site 300267003972 catalytic residues [active] 300267003973 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 300267003974 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 300267003975 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 300267003976 methionine sulfoxide reductase B; Provisional; Region: PRK00222 300267003977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 300267003978 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 300267003979 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 300267003980 putative NAD(P) binding site [chemical binding]; other site 300267003981 catalytic Zn binding site [ion binding]; other site 300267003982 structural Zn binding site [ion binding]; other site 300267003983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267003984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 300267003985 putative substrate translocation pore; other site 300267003986 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 300267003987 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 300267003988 inhibitor binding site; inhibition site 300267003989 catalytic Zn binding site [ion binding]; other site 300267003990 structural Zn binding site [ion binding]; other site 300267003991 NADP binding site [chemical binding]; other site 300267003992 tetramer interface [polypeptide binding]; other site 300267003993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267003994 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267003995 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267003996 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 300267003997 substrate binding site [chemical binding]; other site 300267003998 ATP binding site [chemical binding]; other site 300267003999 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 300267004000 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 300267004001 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267004002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004003 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004004 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004006 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004007 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004008 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004009 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004011 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004012 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004013 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 300267004014 catalytic triad [active] 300267004015 metal binding site [ion binding]; metal-binding site 300267004016 conserved cis-peptide bond; other site 300267004017 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 300267004018 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 300267004019 active site 300267004020 homodimer interface [polypeptide binding]; other site 300267004021 protease 4; Provisional; Region: PRK10949 300267004022 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 300267004023 tandem repeat interface [polypeptide binding]; other site 300267004024 oligomer interface [polypeptide binding]; other site 300267004025 active site residues [active] 300267004026 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 300267004027 tandem repeat interface [polypeptide binding]; other site 300267004028 oligomer interface [polypeptide binding]; other site 300267004029 active site residues [active] 300267004030 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 300267004031 putative FMN binding site [chemical binding]; other site 300267004032 selenophosphate synthetase; Provisional; Region: PRK00943 300267004033 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 300267004034 dimerization interface [polypeptide binding]; other site 300267004035 putative ATP binding site [chemical binding]; other site 300267004036 DNA topoisomerase III; Provisional; Region: PRK07726 300267004037 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 300267004038 active site 300267004039 putative interdomain interaction site [polypeptide binding]; other site 300267004040 putative metal-binding site [ion binding]; other site 300267004041 putative nucleotide binding site [chemical binding]; other site 300267004042 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 300267004043 domain I; other site 300267004044 DNA binding groove [nucleotide binding] 300267004045 phosphate binding site [ion binding]; other site 300267004046 domain II; other site 300267004047 domain III; other site 300267004048 nucleotide binding site [chemical binding]; other site 300267004049 catalytic site [active] 300267004050 domain IV; other site 300267004051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004052 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004053 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004054 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004056 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004057 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004058 hypothetical protein; Provisional; Region: PRK11380 300267004059 glutamate dehydrogenase; Provisional; Region: PRK09414 300267004060 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 300267004061 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 300267004062 NAD(P) binding site [chemical binding]; other site 300267004063 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 300267004064 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 300267004065 active site 300267004066 8-oxo-dGMP binding site [chemical binding]; other site 300267004067 nudix motif; other site 300267004068 metal binding site [ion binding]; metal-binding site 300267004069 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 300267004070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267004071 Walker A/P-loop; other site 300267004072 ATP binding site [chemical binding]; other site 300267004073 Q-loop/lid; other site 300267004074 ABC transporter signature motif; other site 300267004075 Walker B; other site 300267004076 D-loop; other site 300267004077 H-loop/switch region; other site 300267004078 Uncharacterized conserved protein [Function unknown]; Region: COG2128 300267004079 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 300267004080 Uncharacterized conserved protein [Function unknown]; Region: COG0398 300267004081 Uncharacterized conserved protein [Function unknown]; Region: COG0398 300267004082 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 300267004083 putative catalytic site [active] 300267004084 putative phosphate binding site [ion binding]; other site 300267004085 active site 300267004086 metal binding site A [ion binding]; metal-binding site 300267004087 DNA binding site [nucleotide binding] 300267004088 putative AP binding site [nucleotide binding]; other site 300267004089 putative metal binding site B [ion binding]; other site 300267004090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004091 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004092 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004093 arginine succinyltransferase; Provisional; Region: PRK10456 300267004094 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 300267004095 NAD(P) binding site [chemical binding]; other site 300267004096 catalytic residues [active] 300267004097 succinylarginine dihydrolase; Provisional; Region: PRK13281 300267004098 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 300267004099 dimer interface [polypeptide binding]; other site 300267004100 HutD; Region: HutD; cl01532 300267004101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004102 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004103 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004104 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 300267004105 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 300267004106 GIY-YIG motif/motif A; other site 300267004107 active site 300267004108 catalytic site [active] 300267004109 putative DNA binding site [nucleotide binding]; other site 300267004110 metal binding site [ion binding]; metal-binding site 300267004111 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 300267004112 homodimer interface [polypeptide binding]; other site 300267004113 NAD binding pocket [chemical binding]; other site 300267004114 ATP binding pocket [chemical binding]; other site 300267004115 Mg binding site [ion binding]; other site 300267004116 active-site loop [active] 300267004117 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 300267004118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004119 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004120 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004121 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004123 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004124 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004125 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004126 GlpM protein; Region: GlpM; pfam06942 300267004127 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 300267004128 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 300267004129 NADP binding site [chemical binding]; other site 300267004130 substrate binding pocket [chemical binding]; other site 300267004131 active site 300267004132 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 300267004133 Spore germination protein; Region: Spore_permease; cl17796 300267004134 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 300267004135 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 300267004136 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 300267004137 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 300267004138 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 300267004139 ligand binding site [chemical binding]; other site 300267004140 homodimer interface [polypeptide binding]; other site 300267004141 NAD(P) binding site [chemical binding]; other site 300267004142 trimer interface B [polypeptide binding]; other site 300267004143 trimer interface A [polypeptide binding]; other site 300267004144 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 300267004145 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 300267004146 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 300267004147 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 300267004148 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 300267004149 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 300267004150 acid shock protein precursor; Provisional; Region: PRK03577 300267004151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004152 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004153 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004154 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004155 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 300267004156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267004157 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 300267004158 dimerization interface [polypeptide binding]; other site 300267004159 substrate binding pocket [chemical binding]; other site 300267004160 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 300267004161 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 300267004162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267004163 nucleotide binding site [chemical binding]; other site 300267004164 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 300267004165 putative dithiobiotin synthetase; Provisional; Region: PRK12374 300267004166 AAA domain; Region: AAA_26; pfam13500 300267004167 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 300267004168 Cl- selectivity filter; other site 300267004169 Cl- binding residues [ion binding]; other site 300267004170 pore gating glutamate residue; other site 300267004171 dimer interface [polypeptide binding]; other site 300267004172 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 300267004173 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 300267004174 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 300267004175 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 300267004176 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 300267004177 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 300267004178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004179 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004180 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004181 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004182 hypothetical protein; Provisional; Region: PRK13659 300267004183 hypothetical protein; Provisional; Region: PRK02237 300267004184 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004186 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004187 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004188 metabolite-proton symporter; Region: 2A0106; TIGR00883 300267004189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004190 putative substrate translocation pore; other site 300267004191 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 300267004192 Transcriptional regulators [Transcription]; Region: GntR; COG1802 300267004193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267004194 DNA-binding site [nucleotide binding]; DNA binding site 300267004195 FCD domain; Region: FCD; pfam07729 300267004196 malonic semialdehyde reductase; Provisional; Region: PRK10538 300267004197 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 300267004198 putative NAD(P) binding site [chemical binding]; other site 300267004199 homodimer interface [polypeptide binding]; other site 300267004200 homotetramer interface [polypeptide binding]; other site 300267004201 active site 300267004202 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 300267004203 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 300267004204 active site 300267004205 Zn binding site [ion binding]; other site 300267004206 hypothetical protein; Validated; Region: PRK03657 300267004207 hypothetical protein; Provisional; Region: PRK10053 300267004208 diguanylate cyclase; Provisional; Region: PRK09894 300267004209 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 300267004210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267004211 metal binding site [ion binding]; metal-binding site 300267004212 active site 300267004213 I-site; other site 300267004214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004215 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004216 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004217 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004218 putative transporter; Provisional; Region: PRK10054 300267004219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004220 putative substrate translocation pore; other site 300267004221 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 300267004222 EamA-like transporter family; Region: EamA; pfam00892 300267004223 EamA-like transporter family; Region: EamA; pfam00892 300267004224 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 300267004225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267004226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267004227 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 300267004228 Transcriptional regulators [Transcription]; Region: MarR; COG1846 300267004229 inner membrane protein; Provisional; Region: PRK10995 300267004230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 300267004232 putative substrate translocation pore; other site 300267004233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004234 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004235 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004236 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004237 aromatic amino acid exporter; Provisional; Region: PRK11689 300267004238 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 300267004239 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 300267004240 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 300267004241 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 300267004242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267004243 non-specific DNA binding site [nucleotide binding]; other site 300267004244 salt bridge; other site 300267004245 sequence-specific DNA binding site [nucleotide binding]; other site 300267004246 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 300267004247 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 300267004248 NAD binding site [chemical binding]; other site 300267004249 substrate binding site [chemical binding]; other site 300267004250 catalytic Zn binding site [ion binding]; other site 300267004251 tetramer interface [polypeptide binding]; other site 300267004252 structural Zn binding site [ion binding]; other site 300267004253 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 300267004254 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 300267004255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267004256 Walker A/P-loop; other site 300267004257 ATP binding site [chemical binding]; other site 300267004258 Q-loop/lid; other site 300267004259 ABC transporter signature motif; other site 300267004260 Walker B; other site 300267004261 D-loop; other site 300267004262 H-loop/switch region; other site 300267004263 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 300267004264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 300267004265 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 300267004266 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 300267004267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267004268 catalytic residue [active] 300267004269 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 300267004270 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 300267004271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004272 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004273 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004275 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004276 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004277 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 300267004278 putative active site; other site 300267004279 catalytic residue [active] 300267004280 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 300267004281 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 300267004282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267004283 S-adenosylmethionine binding site [chemical binding]; other site 300267004284 MASE1; Region: MASE1; cl17823 300267004285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267004286 metal binding site [ion binding]; metal-binding site 300267004287 active site 300267004288 I-site; other site 300267004289 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 300267004290 glutaminase; Provisional; Region: PRK00971 300267004291 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 300267004292 NAD(P) binding site [chemical binding]; other site 300267004293 catalytic residues [active] 300267004294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 300267004295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267004296 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 300267004297 putative dimerization interface [polypeptide binding]; other site 300267004298 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004299 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 300267004300 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 300267004301 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 300267004302 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 300267004303 peptide binding site [polypeptide binding]; other site 300267004304 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 300267004305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267004306 dimer interface [polypeptide binding]; other site 300267004307 conserved gate region; other site 300267004308 putative PBP binding loops; other site 300267004309 ABC-ATPase subunit interface; other site 300267004310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004311 Transposase; Region: HTH_Tnp_1; pfam01527 300267004312 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267004313 HTH-like domain; Region: HTH_21; pfam13276 300267004314 Integrase core domain; Region: rve; pfam00665 300267004315 Integrase core domain; Region: rve_3; pfam13683 300267004316 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267004317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004318 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 300267004319 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 300267004320 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 300267004321 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 300267004322 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 300267004323 hypothetical protein; Provisional; Region: PRK10281 300267004324 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 300267004325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004326 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004327 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004328 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 300267004329 Fimbrial protein; Region: Fimbrial; cl01416 300267004330 putative oxidoreductase; Provisional; Region: PRK09939 300267004331 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 300267004332 putative molybdopterin cofactor binding site [chemical binding]; other site 300267004333 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 300267004334 putative molybdopterin cofactor binding site; other site 300267004335 transcriptional regulator YdeO; Provisional; Region: PRK09940 300267004336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267004337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267004338 Sulfatase; Region: Sulfatase; cl19157 300267004339 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004341 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004342 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004343 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 300267004344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004345 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004346 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004347 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004349 Transposase; Region: HTH_Tnp_1; pfam01527 300267004350 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 300267004351 CoenzymeA binding site [chemical binding]; other site 300267004352 subunit interaction site [polypeptide binding]; other site 300267004353 PHB binding site; other site 300267004354 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 300267004355 FAD binding domain; Region: FAD_binding_4; pfam01565 300267004356 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 300267004357 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 300267004358 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 300267004359 putative inner membrane protein; Provisional; Region: PRK10983 300267004360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004361 Transposase; Region: HTH_Tnp_1; pfam01527 300267004362 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 300267004363 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004365 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004366 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004369 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004370 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267004372 metal binding site [ion binding]; metal-binding site 300267004373 active site 300267004374 I-site; other site 300267004375 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 300267004376 putative deacylase active site [active] 300267004377 Predicted membrane protein [Function unknown]; Region: COG2707 300267004378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 300267004379 cyanate transporter; Region: CynX; TIGR00896 300267004380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004381 putative substrate translocation pore; other site 300267004382 Uncharacterized conserved protein [Function unknown]; Region: COG3189 300267004383 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 300267004384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 300267004385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267004386 metal binding site [ion binding]; metal-binding site 300267004387 active site 300267004388 I-site; other site 300267004389 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004391 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004392 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004393 hypothetical protein; Provisional; Region: PRK10457 300267004394 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 300267004395 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 300267004396 leucine export protein LeuE; Provisional; Region: PRK10958 300267004397 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004399 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004400 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004401 transcriptional activator TtdR; Provisional; Region: PRK09801 300267004402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267004403 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 300267004404 putative effector binding pocket; other site 300267004405 putative dimerization interface [polypeptide binding]; other site 300267004406 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 300267004407 BCCT family transporter; Region: BCCT; cl00569 300267004408 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004409 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 300267004410 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 300267004411 [2Fe-2S] cluster binding site [ion binding]; other site 300267004412 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 300267004413 putative alpha subunit interface [polypeptide binding]; other site 300267004414 putative active site [active] 300267004415 putative substrate binding site [chemical binding]; other site 300267004416 Fe binding site [ion binding]; other site 300267004417 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 300267004418 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 300267004419 FMN-binding pocket [chemical binding]; other site 300267004420 flavin binding motif; other site 300267004421 phosphate binding motif [ion binding]; other site 300267004422 beta-alpha-beta structure motif; other site 300267004423 NAD binding pocket [chemical binding]; other site 300267004424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 300267004425 catalytic loop [active] 300267004426 iron binding site [ion binding]; other site 300267004427 ribonuclease D; Provisional; Region: PRK10829 300267004428 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 300267004429 catalytic site [active] 300267004430 putative active site [active] 300267004431 putative substrate binding site [chemical binding]; other site 300267004432 Helicase and RNase D C-terminal; Region: HRDC; smart00341 300267004433 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 300267004434 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 300267004435 acyl-activating enzyme (AAE) consensus motif; other site 300267004436 putative AMP binding site [chemical binding]; other site 300267004437 putative active site [active] 300267004438 putative CoA binding site [chemical binding]; other site 300267004439 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 300267004440 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 300267004441 Glycoprotease family; Region: Peptidase_M22; pfam00814 300267004442 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 300267004443 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 300267004444 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 300267004445 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 300267004446 homotrimer interaction site [polypeptide binding]; other site 300267004447 putative active site [active] 300267004448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004449 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004450 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004451 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004452 hypothetical protein; Provisional; Region: PRK05114 300267004453 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 300267004454 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 300267004455 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 300267004456 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 300267004457 putative active site [active] 300267004458 putative CoA binding site [chemical binding]; other site 300267004459 nudix motif; other site 300267004460 L-serine deaminase; Provisional; Region: PRK15023 300267004461 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 300267004462 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 300267004463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004464 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004465 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004466 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004467 DNA-binding site [nucleotide binding]; DNA binding site 300267004468 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 300267004469 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 300267004470 Prostaglandin dehydrogenases; Region: PGDH; cd05288 300267004471 NAD(P) binding site [chemical binding]; other site 300267004472 substrate binding site [chemical binding]; other site 300267004473 dimer interface [polypeptide binding]; other site 300267004474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 300267004475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267004476 Coenzyme A binding pocket [chemical binding]; other site 300267004477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 300267004478 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004480 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004481 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004482 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 300267004483 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 300267004484 tetrameric interface [polypeptide binding]; other site 300267004485 NAD binding site [chemical binding]; other site 300267004486 catalytic residues [active] 300267004487 substrate binding site [chemical binding]; other site 300267004488 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 300267004489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267004490 Walker A/P-loop; other site 300267004491 ATP binding site [chemical binding]; other site 300267004492 Q-loop/lid; other site 300267004493 ABC transporter signature motif; other site 300267004494 Walker B; other site 300267004495 D-loop; other site 300267004496 H-loop/switch region; other site 300267004497 TOBE domain; Region: TOBE_2; pfam08402 300267004498 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 300267004499 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 300267004500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267004501 DNA-binding site [nucleotide binding]; DNA binding site 300267004502 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267004503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267004504 homodimer interface [polypeptide binding]; other site 300267004505 catalytic residue [active] 300267004506 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 300267004507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267004508 sequence-specific DNA binding site [nucleotide binding]; other site 300267004509 salt bridge; other site 300267004510 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004512 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004513 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004514 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 300267004515 Collagenase; Region: DUF3656; pfam12392 300267004516 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 300267004517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267004518 non-specific DNA binding site [nucleotide binding]; other site 300267004519 salt bridge; other site 300267004520 sequence-specific DNA binding site [nucleotide binding]; other site 300267004521 Cupin domain; Region: Cupin_2; pfam07883 300267004522 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004524 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004525 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004526 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 300267004527 tellurite resistance protein TehB; Provisional; Region: PRK11207 300267004528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267004529 S-adenosylmethionine binding site [chemical binding]; other site 300267004530 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 300267004531 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 300267004532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267004533 Coenzyme A binding pocket [chemical binding]; other site 300267004534 hypothetical protein; Provisional; Region: PRK11415 300267004535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004536 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004537 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004538 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004539 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 300267004540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 300267004541 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 300267004542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267004543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 300267004544 dimerization interface [polypeptide binding]; other site 300267004545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004546 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004547 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004548 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004549 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 300267004550 dimer interface [polypeptide binding]; other site 300267004551 ligand binding site [chemical binding]; other site 300267004552 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 300267004553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267004554 dimerization interface [polypeptide binding]; other site 300267004555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 300267004556 dimer interface [polypeptide binding]; other site 300267004557 putative CheW interface [polypeptide binding]; other site 300267004558 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004560 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004561 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004562 hypothetical protein; Provisional; Region: PRK10040 300267004563 cytochrome b561; Provisional; Region: PRK11513 300267004564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004565 Transposase; Region: HTH_Tnp_1; pfam01527 300267004566 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004568 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004569 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004571 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004572 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004573 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004574 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 300267004575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267004576 ATP binding site [chemical binding]; other site 300267004577 putative Mg++ binding site [ion binding]; other site 300267004578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267004579 nucleotide binding region [chemical binding]; other site 300267004580 ATP-binding site [chemical binding]; other site 300267004581 Helicase associated domain (HA2); Region: HA2; pfam04408 300267004582 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 300267004583 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 300267004584 azoreductase; Reviewed; Region: PRK00170 300267004585 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 300267004586 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 300267004587 active site 300267004588 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cd00127 300267004589 active site 300267004590 catalytic residues [active] 300267004591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004592 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004593 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004594 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004595 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 300267004596 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 300267004597 Putative methyltransferase; Region: Methyltransf_20; pfam12147 300267004598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267004599 S-adenosylmethionine binding site [chemical binding]; other site 300267004600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004601 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004602 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004603 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 300267004604 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 300267004605 active site 300267004606 HTH-like domain; Region: HTH_21; pfam13276 300267004607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267004608 Integrase core domain; Region: rve; pfam00665 300267004609 Integrase core domain; Region: rve_3; pfam13683 300267004610 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 300267004611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004612 Transposase; Region: HTH_Tnp_1; pfam01527 300267004613 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 300267004614 Cupin domain; Region: Cupin_2; pfam07883 300267004615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004616 Transposase; Region: HTH_Tnp_1; pfam01527 300267004617 oxidoreductase; Provisional; Region: PRK10015 300267004618 putative oxidoreductase FixC; Provisional; Region: PRK10157 300267004619 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 300267004620 phosphoenolpyruvate synthase; Validated; Region: PRK06464 300267004621 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 300267004622 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 300267004623 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 300267004624 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267004625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004626 PEP synthetase regulatory protein; Provisional; Region: PRK05339 300267004627 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 300267004628 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 300267004629 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 300267004630 NlpC/P60 family; Region: NLPC_P60; pfam00877 300267004631 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 300267004632 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 300267004633 Walker A/P-loop; other site 300267004634 ATP binding site [chemical binding]; other site 300267004635 Q-loop/lid; other site 300267004636 ABC transporter signature motif; other site 300267004637 Walker B; other site 300267004638 D-loop; other site 300267004639 H-loop/switch region; other site 300267004640 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 300267004641 catalytic residues [active] 300267004642 dimer interface [polypeptide binding]; other site 300267004643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267004644 ABC-ATPase subunit interface; other site 300267004645 dimer interface [polypeptide binding]; other site 300267004646 putative PBP binding regions; other site 300267004647 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 300267004648 DNA binding site [nucleotide binding] 300267004649 dimer interface [polypeptide binding]; other site 300267004650 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 300267004651 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 300267004652 putative tRNA-binding site [nucleotide binding]; other site 300267004653 B3/4 domain; Region: B3_4; pfam03483 300267004654 tRNA synthetase B5 domain; Region: B5; smart00874 300267004655 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 300267004656 dimer interface [polypeptide binding]; other site 300267004657 motif 1; other site 300267004658 motif 3; other site 300267004659 motif 2; other site 300267004660 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 300267004661 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 300267004662 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 300267004663 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 300267004664 dimer interface [polypeptide binding]; other site 300267004665 motif 1; other site 300267004666 active site 300267004667 motif 2; other site 300267004668 motif 3; other site 300267004669 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 300267004670 23S rRNA binding site [nucleotide binding]; other site 300267004671 L21 binding site [polypeptide binding]; other site 300267004672 L13 binding site [polypeptide binding]; other site 300267004673 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 300267004674 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 300267004675 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 300267004676 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 300267004677 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 300267004678 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 300267004679 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 300267004680 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 300267004681 active site 300267004682 dimer interface [polypeptide binding]; other site 300267004683 motif 1; other site 300267004684 motif 2; other site 300267004685 motif 3; other site 300267004686 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 300267004687 anticodon binding site; other site 300267004688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004689 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004690 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004691 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004692 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 300267004693 putative substrate binding site [chemical binding]; other site 300267004694 putative ATP binding site [chemical binding]; other site 300267004695 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 300267004696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 300267004697 Phosphotransferase enzyme family; Region: APH; pfam01636 300267004698 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 300267004699 active site 300267004700 substrate binding site [chemical binding]; other site 300267004701 ATP binding site [chemical binding]; other site 300267004702 YniB-like protein; Region: YniB; pfam14002 300267004703 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 300267004704 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 300267004705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267004706 motif II; other site 300267004707 inner membrane protein; Provisional; Region: PRK11648 300267004708 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004710 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004711 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004712 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 300267004713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267004714 active site 300267004715 phosphorylation site [posttranslational modification] 300267004716 intermolecular recognition site; other site 300267004717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267004718 DNA binding site [nucleotide binding] 300267004719 sensor protein RstB; Provisional; Region: PRK10604 300267004720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267004721 dimerization interface [polypeptide binding]; other site 300267004722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267004723 dimer interface [polypeptide binding]; other site 300267004724 phosphorylation site [posttranslational modification] 300267004725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267004726 ATP binding site [chemical binding]; other site 300267004727 Mg2+ binding site [ion binding]; other site 300267004728 G-X-G motif; other site 300267004729 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 300267004730 fumarate hydratase; Reviewed; Region: fumC; PRK00485 300267004731 Class II fumarases; Region: Fumarase_classII; cd01362 300267004732 active site 300267004733 tetramer interface [polypeptide binding]; other site 300267004734 fumarate hydratase; Provisional; Region: PRK15389 300267004735 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 300267004736 Fumarase C-terminus; Region: Fumerase_C; pfam05683 300267004737 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 300267004738 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 300267004739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 300267004740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004741 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004742 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004743 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 300267004745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267004746 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 300267004747 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 300267004748 NAD binding site [chemical binding]; other site 300267004749 substrate binding site [chemical binding]; other site 300267004750 homotetramer interface [polypeptide binding]; other site 300267004751 homodimer interface [polypeptide binding]; other site 300267004752 active site 300267004753 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 300267004754 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267004755 DNA binding site [nucleotide binding] 300267004756 domain linker motif; other site 300267004757 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 300267004758 putative dimerization interface [polypeptide binding]; other site 300267004759 putative ligand binding site [chemical binding]; other site 300267004760 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 300267004761 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 300267004762 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004764 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004765 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004766 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 300267004767 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267004768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267004769 homodimer interface [polypeptide binding]; other site 300267004770 catalytic residue [active] 300267004771 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 300267004772 active site 300267004773 purine riboside binding site [chemical binding]; other site 300267004774 putative oxidoreductase; Provisional; Region: PRK11579 300267004775 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 300267004776 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 300267004777 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 300267004778 electron transport complex protein RsxA; Provisional; Region: PRK05151 300267004779 electron transport complex protein RnfB; Provisional; Region: PRK05113 300267004780 Putative Fe-S cluster; Region: FeS; pfam04060 300267004781 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267004782 electron transport complex protein RnfC; Provisional; Region: PRK05035 300267004783 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 300267004784 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 300267004785 SLBB domain; Region: SLBB; pfam10531 300267004786 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 300267004787 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 300267004788 electron transport complex protein RnfG; Validated; Region: PRK01908 300267004789 electron transport complex RsxE subunit; Provisional; Region: PRK12405 300267004790 endonuclease III; Provisional; Region: PRK10702 300267004791 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 300267004792 minor groove reading motif; other site 300267004793 helix-hairpin-helix signature motif; other site 300267004794 substrate binding pocket [chemical binding]; other site 300267004795 active site 300267004796 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 300267004797 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 300267004798 putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584 300267004799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004800 putative substrate translocation pore; other site 300267004801 glutathionine S-transferase; Provisional; Region: PRK10542 300267004802 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 300267004803 C-terminal domain interface [polypeptide binding]; other site 300267004804 GSH binding site (G-site) [chemical binding]; other site 300267004805 dimer interface [polypeptide binding]; other site 300267004806 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 300267004807 N-terminal domain interface [polypeptide binding]; other site 300267004808 dimer interface [polypeptide binding]; other site 300267004809 substrate binding pocket (H-site) [chemical binding]; other site 300267004810 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 300267004811 dimer interface [polypeptide binding]; other site 300267004812 pyridoxal binding site [chemical binding]; other site 300267004813 ATP binding site [chemical binding]; other site 300267004814 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 300267004815 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 300267004816 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 300267004817 active site 300267004818 HIGH motif; other site 300267004819 dimer interface [polypeptide binding]; other site 300267004820 KMSKS motif; other site 300267004821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267004822 RNA binding surface [nucleotide binding]; other site 300267004823 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 300267004824 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 300267004825 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 300267004826 lysozyme inhibitor; Provisional; Region: PRK11372 300267004827 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 300267004828 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 300267004829 transcriptional regulator SlyA; Provisional; Region: PRK03573 300267004830 Transcriptional regulators [Transcription]; Region: MarR; COG1846 300267004831 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 300267004832 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 300267004833 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 300267004834 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267004835 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 300267004836 E-class dimer interface [polypeptide binding]; other site 300267004837 P-class dimer interface [polypeptide binding]; other site 300267004838 active site 300267004839 Cu2+ binding site [ion binding]; other site 300267004840 Zn2+ binding site [ion binding]; other site 300267004841 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 300267004842 active site 300267004843 catalytic tetrad [active] 300267004844 Predicted Fe-S protein [General function prediction only]; Region: COG3313 300267004845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 300267004846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267004847 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004849 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004850 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004851 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 300267004852 dimer interface [polypeptide binding]; other site 300267004853 active site 300267004854 metal binding site [ion binding]; metal-binding site 300267004855 glutathione binding site [chemical binding]; other site 300267004856 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 300267004857 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 300267004858 dimer interface [polypeptide binding]; other site 300267004859 catalytic site [active] 300267004860 putative active site [active] 300267004861 putative substrate binding site [chemical binding]; other site 300267004862 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 300267004863 putative GSH binding site [chemical binding]; other site 300267004864 catalytic residues [active] 300267004865 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 300267004866 NlpC/P60 family; Region: NLPC_P60; pfam00877 300267004867 superoxide dismutase; Provisional; Region: PRK10543 300267004868 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 300267004869 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 300267004870 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 300267004871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004872 putative substrate translocation pore; other site 300267004873 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 300267004874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267004875 DNA binding site [nucleotide binding] 300267004876 domain linker motif; other site 300267004877 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 300267004878 dimerization interface [polypeptide binding]; other site 300267004879 ligand binding site [chemical binding]; other site 300267004880 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 300267004881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267004882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 300267004883 dimerization interface [polypeptide binding]; other site 300267004884 putative transporter; Provisional; Region: PRK11043 300267004885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267004886 putative substrate translocation pore; other site 300267004887 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 300267004888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 300267004889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267004890 S-adenosylmethionine binding site [chemical binding]; other site 300267004891 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 300267004892 Lumazine binding domain; Region: Lum_binding; pfam00677 300267004893 Lumazine binding domain; Region: Lum_binding; pfam00677 300267004894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004895 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004896 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004897 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004898 multidrug efflux protein; Reviewed; Region: PRK01766 300267004899 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 300267004900 cation binding site [ion binding]; other site 300267004901 hypothetical protein; Provisional; Region: PRK09945 300267004902 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 300267004903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004904 Transposase; Region: HTH_Tnp_1; pfam01527 300267004905 hypothetical protein; Provisional; Region: PRK09946 300267004906 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 300267004907 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 300267004908 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 300267004909 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 300267004910 hypothetical protein; Provisional; Region: PRK09947 300267004911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004912 Transposase; Region: HTH_Tnp_1; pfam01527 300267004913 hypothetical protein; Provisional; Region: PRK10292 300267004914 pyruvate kinase; Provisional; Region: PRK09206 300267004915 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 300267004916 domain interfaces; other site 300267004917 active site 300267004918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004919 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004920 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004921 murein lipoprotein; Provisional; Region: PRK15396 300267004922 L,D-transpeptidase; Provisional; Region: PRK10260 300267004923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 300267004924 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 300267004925 cysteine desufuration protein SufE; Provisional; Region: PRK09296 300267004926 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 300267004927 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 300267004928 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 300267004929 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 300267004930 Walker A/P-loop; other site 300267004931 ATP binding site [chemical binding]; other site 300267004932 Q-loop/lid; other site 300267004933 ABC transporter signature motif; other site 300267004934 Walker B; other site 300267004935 D-loop; other site 300267004936 H-loop/switch region; other site 300267004937 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 300267004938 multiple promoter invertase; Provisional; Region: mpi; PRK13413 300267004939 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 300267004940 catalytic residues [active] 300267004941 catalytic nucleophile [active] 300267004942 Presynaptic Site I dimer interface [polypeptide binding]; other site 300267004943 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 300267004944 Synaptic Flat tetramer interface [polypeptide binding]; other site 300267004945 Synaptic Site I dimer interface [polypeptide binding]; other site 300267004946 DNA binding site [nucleotide binding] 300267004947 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 300267004948 DNA-binding interface [nucleotide binding]; DNA binding site 300267004949 putative transposase OrfB; Reviewed; Region: PHA02517 300267004950 HTH-like domain; Region: HTH_21; pfam13276 300267004951 Integrase core domain; Region: rve; pfam00665 300267004952 Integrase core domain; Region: rve_3; pfam13683 300267004953 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267004954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004955 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004956 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004958 Transposase; Region: HTH_Tnp_1; pfam01527 300267004959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267004960 ATP binding site [chemical binding]; other site 300267004961 putative Mg++ binding site [ion binding]; other site 300267004962 Cro; Region: Cro; pfam09048 300267004963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267004964 non-specific DNA binding site [nucleotide binding]; other site 300267004965 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 300267004966 salt bridge; other site 300267004967 sequence-specific DNA binding site [nucleotide binding]; other site 300267004968 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 300267004969 Catalytic site [active] 300267004970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267004971 S-adenosylmethionine binding site [chemical binding]; other site 300267004972 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 300267004973 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 300267004974 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 300267004975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267004976 Transposase; Region: HTH_Tnp_1; cl17663 300267004977 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 300267004978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267004979 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267004980 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267004981 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267004982 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 300267004983 active site residue [active] 300267004984 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 300267004985 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 300267004986 phage shock protein C; Region: phageshock_pspC; TIGR02978 300267004987 phage shock protein B; Provisional; Region: pspB; PRK09458 300267004988 phage shock protein PspA; Provisional; Region: PRK10698 300267004989 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 300267004990 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 300267004991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267004992 Walker A motif; other site 300267004993 ATP binding site [chemical binding]; other site 300267004994 Walker B motif; other site 300267004995 arginine finger; other site 300267004996 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 300267004997 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 300267004998 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 300267004999 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 300267005000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267005001 non-specific DNA binding site [nucleotide binding]; other site 300267005002 salt bridge; other site 300267005003 sequence-specific DNA binding site [nucleotide binding]; other site 300267005004 Cupin domain; Region: Cupin_2; pfam07883 300267005005 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005007 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005008 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005009 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 300267005010 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 300267005011 C-terminal domain interface [polypeptide binding]; other site 300267005012 GSH binding site (G-site) [chemical binding]; other site 300267005013 dimer interface [polypeptide binding]; other site 300267005014 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 300267005015 dimer interface [polypeptide binding]; other site 300267005016 N-terminal domain interface [polypeptide binding]; other site 300267005017 substrate binding pocket (H-site) [chemical binding]; other site 300267005018 L-asparagine permease; Provisional; Region: PRK15049 300267005019 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267005020 PQQ-like domain; Region: PQQ_2; pfam13360 300267005021 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 300267005022 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 300267005023 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 300267005024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005025 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005026 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005027 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005028 FCD domain; Region: FCD; pfam07729 300267005029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005030 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005031 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005032 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005033 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 300267005034 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 300267005035 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 300267005036 Transporter associated domain; Region: CorC_HlyC; smart01091 300267005037 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 300267005038 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 300267005039 active pocket/dimerization site; other site 300267005040 active site 300267005041 phosphorylation site [posttranslational modification] 300267005042 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 300267005043 active site 300267005044 phosphorylation site [posttranslational modification] 300267005045 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 300267005046 hypothetical protein; Provisional; Region: PRK02913 300267005047 hypothetical protein; Provisional; Region: PRK11469 300267005048 Domain of unknown function DUF; Region: DUF204; pfam02659 300267005049 Domain of unknown function DUF; Region: DUF204; pfam02659 300267005050 Methyltransferase domain; Region: Methyltransf_31; pfam13847 300267005051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267005052 S-adenosylmethionine binding site [chemical binding]; other site 300267005053 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 300267005054 DNA-binding site [nucleotide binding]; DNA binding site 300267005055 RNA-binding motif; other site 300267005056 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 300267005057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005058 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005059 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005060 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005061 YebO-like protein; Region: YebO; pfam13974 300267005062 PhoPQ regulatory protein; Provisional; Region: PRK10299 300267005063 YobH-like protein; Region: YobH; pfam13996 300267005064 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 300267005065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 300267005066 dimerization interface [polypeptide binding]; other site 300267005067 putative Zn2+ binding site [ion binding]; other site 300267005068 putative DNA binding site [nucleotide binding]; other site 300267005069 Bacterial transcriptional regulator; Region: IclR; pfam01614 300267005070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267005071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 300267005072 putative substrate translocation pore; other site 300267005073 Predicted integral membrane protein [Function unknown]; Region: COG5521 300267005074 heat shock protein HtpX; Provisional; Region: PRK05457 300267005075 carboxy-terminal protease; Provisional; Region: PRK11186 300267005076 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 300267005077 protein binding site [polypeptide binding]; other site 300267005078 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 300267005079 Catalytic dyad [active] 300267005080 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 300267005081 ProP expression regulator; Provisional; Region: PRK04950 300267005082 putative RNA binding sites [nucleotide binding]; other site 300267005083 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 300267005084 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 300267005085 Paraquat-inducible protein A; Region: PqiA; pfam04403 300267005086 Paraquat-inducible protein A; Region: PqiA; pfam04403 300267005087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005088 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005089 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005090 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005091 Paraquat-inducible protein A; Region: PqiA; pfam04403 300267005092 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 300267005093 mce related protein; Region: MCE; pfam02470 300267005094 mce related protein; Region: MCE; pfam02470 300267005095 mce related protein; Region: MCE; pfam02470 300267005096 mce related protein; Region: MCE; pfam02470 300267005097 mce related protein; Region: MCE; pfam02470 300267005098 mce related protein; Region: MCE; pfam02470 300267005099 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 300267005100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267005101 S-adenosylmethionine binding site [chemical binding]; other site 300267005102 Uncharacterized conserved protein [Function unknown]; Region: COG3270 300267005103 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 300267005104 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 300267005105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005106 Transposase; Region: HTH_Tnp_1; cl17663 300267005107 putative transposase OrfB; Reviewed; Region: PHA02517 300267005108 HTH-like domain; Region: HTH_21; pfam13276 300267005109 Integrase core domain; Region: rve; pfam00665 300267005110 Integrase core domain; Region: rve_3; pfam13683 300267005111 Lysis protein S; Region: Lysis_S; pfam04971 300267005112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005113 Transposase; Region: HTH_Tnp_1; pfam01527 300267005114 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267005115 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 300267005116 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 300267005117 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 300267005118 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 300267005119 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267005120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005121 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005122 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005123 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005124 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267005125 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 300267005126 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267005127 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 300267005128 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005130 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005131 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005133 Transposase; Region: HTH_Tnp_1; pfam01527 300267005134 6-phosphogluconolactonase; Provisional; Region: PRK11028 300267005135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 300267005136 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 300267005137 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005139 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005140 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005141 anti-adapter protein IraM; Provisional; Region: PRK09919 300267005142 isocitrate dehydrogenase; Reviewed; Region: PRK07006 300267005143 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 300267005144 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 300267005145 probable active site [active] 300267005146 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 300267005147 nudix motif; other site 300267005148 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 300267005149 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 300267005150 Ligand Binding Site [chemical binding]; other site 300267005151 putative lysogenization regulator; Reviewed; Region: PRK00218 300267005152 adenylosuccinate lyase; Provisional; Region: PRK09285 300267005153 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 300267005154 tetramer interface [polypeptide binding]; other site 300267005155 active site 300267005156 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 300267005157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267005158 active site 300267005159 phosphorylation site [posttranslational modification] 300267005160 intermolecular recognition site; other site 300267005161 dimerization interface [polypeptide binding]; other site 300267005162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267005163 DNA binding site [nucleotide binding] 300267005164 sensor protein PhoQ; Provisional; Region: PRK10815 300267005165 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 300267005166 HAMP domain; Region: HAMP; pfam00672 300267005167 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 300267005168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267005169 ATP binding site [chemical binding]; other site 300267005170 Mg2+ binding site [ion binding]; other site 300267005171 G-X-G motif; other site 300267005172 Uncharacterized conserved protein [Function unknown]; Region: COG2850 300267005173 peptidase T-like protein; Region: PepT-like; TIGR01883 300267005174 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 300267005175 metal binding site [ion binding]; metal-binding site 300267005176 dimer interface [polypeptide binding]; other site 300267005177 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 300267005178 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 300267005179 Walker A/P-loop; other site 300267005180 ATP binding site [chemical binding]; other site 300267005181 Q-loop/lid; other site 300267005182 ABC transporter signature motif; other site 300267005183 Walker B; other site 300267005184 D-loop; other site 300267005185 H-loop/switch region; other site 300267005186 TOBE domain; Region: TOBE_2; pfam08402 300267005187 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 300267005188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267005189 dimer interface [polypeptide binding]; other site 300267005190 conserved gate region; other site 300267005191 putative PBP binding loops; other site 300267005192 ABC-ATPase subunit interface; other site 300267005193 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 300267005194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267005195 dimer interface [polypeptide binding]; other site 300267005196 conserved gate region; other site 300267005197 putative PBP binding loops; other site 300267005198 ABC-ATPase subunit interface; other site 300267005199 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 300267005200 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 300267005201 NAD+ binding site [chemical binding]; other site 300267005202 substrate binding site [chemical binding]; other site 300267005203 Zn binding site [ion binding]; other site 300267005204 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 300267005205 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267005206 nucleotide binding site [chemical binding]; other site 300267005207 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 300267005208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 300267005209 FtsX-like permease family; Region: FtsX; pfam02687 300267005210 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 300267005211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 300267005212 Walker A/P-loop; other site 300267005213 ATP binding site [chemical binding]; other site 300267005214 Q-loop/lid; other site 300267005215 ABC transporter signature motif; other site 300267005216 Walker B; other site 300267005217 D-loop; other site 300267005218 H-loop/switch region; other site 300267005219 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 300267005220 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 300267005221 FtsX-like permease family; Region: FtsX; pfam02687 300267005222 Predicted membrane protein [Function unknown]; Region: COG4763 300267005223 transcription-repair coupling factor; Provisional; Region: PRK10689 300267005224 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 300267005225 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 300267005226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267005227 ATP binding site [chemical binding]; other site 300267005228 putative Mg++ binding site [ion binding]; other site 300267005229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267005230 nucleotide binding region [chemical binding]; other site 300267005231 ATP-binding site [chemical binding]; other site 300267005232 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 300267005233 L,D-transpeptidase; Provisional; Region: PRK10260 300267005234 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 300267005235 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 300267005236 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 300267005237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 300267005238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267005239 hypothetical protein; Provisional; Region: PRK11280 300267005240 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 300267005241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267005242 hypothetical protein; Provisional; Region: PRK04940 300267005243 beta-hexosaminidase; Provisional; Region: PRK05337 300267005244 Phosphotransferase enzyme family; Region: APH; pfam01636 300267005245 active site 300267005246 substrate binding site [chemical binding]; other site 300267005247 ATP binding site [chemical binding]; other site 300267005248 thiamine kinase; Provisional; Region: thiK; PRK10271 300267005249 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 300267005250 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 300267005251 putative dimer interface [polypeptide binding]; other site 300267005252 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 300267005253 nucleotide binding site/active site [active] 300267005254 HIT family signature motif; other site 300267005255 catalytic residue [active] 300267005256 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 300267005257 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267005258 N-terminal plug; other site 300267005259 ligand-binding site [chemical binding]; other site 300267005260 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 300267005261 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 300267005262 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 300267005263 active site turn [active] 300267005264 phosphorylation site [posttranslational modification] 300267005265 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 300267005266 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 300267005267 active site 300267005268 DNA polymerase III subunit delta'; Validated; Region: PRK07993 300267005269 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 300267005270 thymidylate kinase; Validated; Region: tmk; PRK00698 300267005271 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 300267005272 TMP-binding site; other site 300267005273 ATP-binding site [chemical binding]; other site 300267005274 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 300267005275 dimerization interface [polypeptide binding]; other site 300267005276 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 300267005277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267005278 catalytic residue [active] 300267005279 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 300267005280 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 300267005281 dimer interface [polypeptide binding]; other site 300267005282 active site 300267005283 acyl carrier protein; Provisional; Region: acpP; PRK00982 300267005284 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 300267005285 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 300267005286 NAD(P) binding site [chemical binding]; other site 300267005287 homotetramer interface [polypeptide binding]; other site 300267005288 homodimer interface [polypeptide binding]; other site 300267005289 active site 300267005290 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 300267005291 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 300267005292 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 300267005293 dimer interface [polypeptide binding]; other site 300267005294 active site 300267005295 CoA binding pocket [chemical binding]; other site 300267005296 putative phosphate acyltransferase; Provisional; Region: PRK05331 300267005297 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 300267005298 hypothetical protein; Provisional; Region: PRK11193 300267005299 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005300 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 300267005301 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267005302 RNA binding surface [nucleotide binding]; other site 300267005303 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 300267005304 active site 300267005305 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 300267005306 ribonuclease E; Reviewed; Region: rne; PRK10811 300267005307 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 300267005308 homodimer interface [polypeptide binding]; other site 300267005309 oligonucleotide binding site [chemical binding]; other site 300267005310 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 300267005311 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 300267005312 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 300267005313 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 300267005314 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 300267005315 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 300267005316 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 300267005317 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 300267005318 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 300267005319 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 300267005320 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 300267005321 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 300267005322 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 300267005323 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 300267005324 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 300267005325 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 300267005326 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 300267005327 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 300267005328 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 300267005329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005330 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005331 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005332 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005333 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 300267005334 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 300267005335 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 300267005336 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 300267005337 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 300267005338 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 300267005339 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 300267005340 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 300267005341 hypothetical protein; Provisional; Region: PRK11239 300267005342 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 300267005343 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 300267005344 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005346 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005347 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005348 glutaredoxin 2; Provisional; Region: PRK10387 300267005349 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 300267005350 C-terminal domain interface [polypeptide binding]; other site 300267005351 GSH binding site (G-site) [chemical binding]; other site 300267005352 catalytic residues [active] 300267005353 putative dimer interface [polypeptide binding]; other site 300267005354 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 300267005355 N-terminal domain interface [polypeptide binding]; other site 300267005356 lipoprotein; Provisional; Region: PRK10598 300267005357 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 300267005358 active site 300267005359 substrate binding pocket [chemical binding]; other site 300267005360 dimer interface [polypeptide binding]; other site 300267005361 DNA damage-inducible protein I; Provisional; Region: PRK10597 300267005362 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005364 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005365 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005366 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 300267005367 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 300267005368 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 300267005369 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 300267005370 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005372 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005373 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005374 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 300267005375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 300267005376 ligand binding site [chemical binding]; other site 300267005377 flexible hinge region; other site 300267005378 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 300267005379 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005381 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005382 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005384 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005385 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005386 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 300267005387 tetramer interface [polypeptide binding]; other site 300267005388 active site 300267005389 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 300267005390 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 300267005391 Nucleoside recognition; Region: Gate; pfam07670 300267005392 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 300267005393 putative kinase; Provisional; Region: PRK09954 300267005394 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 300267005395 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 300267005396 substrate binding site [chemical binding]; other site 300267005397 ATP binding site [chemical binding]; other site 300267005398 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 300267005399 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 300267005400 AP (apurinic/apyrimidinic) site pocket; other site 300267005401 DNA interaction; other site 300267005402 Metal-binding active site; metal-binding site 300267005403 conserved hypothetical integral membrane protein; Region: TIGR00698 300267005404 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 300267005405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267005406 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 300267005407 putative dimerization interface [polypeptide binding]; other site 300267005408 lysine transporter; Provisional; Region: PRK10836 300267005409 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267005410 Predicted esterase [General function prediction only]; Region: COG0627 300267005411 S-formylglutathione hydrolase; Region: PLN02442 300267005412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005413 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005414 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005415 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 300267005416 Domain of unknown function (DUF336); Region: DUF336; cl01249 300267005417 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 300267005418 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 300267005419 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 300267005420 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 300267005421 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005422 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 300267005423 Sulfatase; Region: Sulfatase; cl19157 300267005424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005425 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005426 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005427 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005428 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 300267005429 homodecamer interface [polypeptide binding]; other site 300267005430 active site 300267005431 putative catalytic site residues [active] 300267005432 zinc binding site [ion binding]; other site 300267005433 GTP-CH-I/GFRP interaction surface; other site 300267005434 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 300267005435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267005436 DNA binding site [nucleotide binding] 300267005437 domain linker motif; other site 300267005438 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 300267005439 dimerization interface (closed form) [polypeptide binding]; other site 300267005440 ligand binding site [chemical binding]; other site 300267005441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 300267005442 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 300267005443 ligand binding site [chemical binding]; other site 300267005444 calcium binding site [ion binding]; other site 300267005445 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005446 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005447 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005449 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005450 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005451 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 300267005452 TM-ABC transporter signature motif; other site 300267005453 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005455 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005456 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005457 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 300267005458 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 300267005459 homodimer interface [polypeptide binding]; other site 300267005460 active site 300267005461 FMN binding site [chemical binding]; other site 300267005462 substrate binding site [chemical binding]; other site 300267005463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005464 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005465 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005466 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005467 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 300267005468 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 300267005469 putative active site [active] 300267005470 cytidine deaminase; Provisional; Region: PRK09027 300267005471 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 300267005472 active site 300267005473 catalytic motif [active] 300267005474 Zn binding site [ion binding]; other site 300267005475 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 300267005476 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 300267005477 active site 300267005478 catalytic motif [active] 300267005479 Zn binding site [ion binding]; other site 300267005480 hypothetical protein; Provisional; Region: PRK10711 300267005481 hypothetical protein; Provisional; Region: PRK01821 300267005482 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005484 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005485 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005486 oxidoreductase; Provisional; Region: PRK12743 300267005487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 300267005488 NAD(P) binding site [chemical binding]; other site 300267005489 active site 300267005490 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 300267005491 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 300267005492 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 300267005493 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 300267005494 D-lactate dehydrogenase; Provisional; Region: PRK11183 300267005495 FAD binding domain; Region: FAD_binding_4; cl19922 300267005496 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 300267005497 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 300267005498 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 300267005499 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 300267005500 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 300267005501 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 300267005502 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 300267005503 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 300267005504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267005505 dimer interface [polypeptide binding]; other site 300267005506 conserved gate region; other site 300267005507 putative PBP binding loops; other site 300267005508 ABC-ATPase subunit interface; other site 300267005509 hypothetical protein; Provisional; Region: PRK13681 300267005510 transcriptional regulator MirA; Provisional; Region: PRK15043 300267005511 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 300267005512 DNA binding residues [nucleotide binding] 300267005513 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 300267005514 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 300267005515 GAF domain; Region: GAF; pfam01590 300267005516 Histidine kinase; Region: His_kinase; pfam06580 300267005517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267005518 ATP binding site [chemical binding]; other site 300267005519 Mg2+ binding site [ion binding]; other site 300267005520 G-X-G motif; other site 300267005521 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 300267005522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267005523 active site 300267005524 phosphorylation site [posttranslational modification] 300267005525 intermolecular recognition site; other site 300267005526 dimerization interface [polypeptide binding]; other site 300267005527 LytTr DNA-binding domain; Region: LytTR; pfam04397 300267005528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 300267005529 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 300267005530 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 300267005531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 300267005532 Peptidase family C69; Region: Peptidase_C69; cl17793 300267005533 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267005534 HTH-like domain; Region: HTH_21; pfam13276 300267005535 Integrase core domain; Region: rve; pfam00665 300267005536 Integrase core domain; Region: rve_3; pfam13683 300267005537 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267005538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005540 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005541 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005542 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005543 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005545 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005546 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005547 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 300267005548 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 300267005549 active site 300267005550 HIGH motif; other site 300267005551 KMSKS motif; other site 300267005552 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 300267005553 tRNA binding surface [nucleotide binding]; other site 300267005554 anticodon binding site; other site 300267005555 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 300267005556 dimer interface [polypeptide binding]; other site 300267005557 putative tRNA-binding site [nucleotide binding]; other site 300267005558 antiporter inner membrane protein; Provisional; Region: PRK11670 300267005559 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 300267005560 Walker A motif; other site 300267005561 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 300267005562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005563 Transposase; Region: HTH_Tnp_1; pfam01527 300267005564 HTH-like domain; Region: HTH_21; pfam13276 300267005565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267005566 Integrase core domain; Region: rve; pfam00665 300267005567 Integrase core domain; Region: rve_3; pfam13683 300267005568 Uncharacterized conserved protein [Function unknown]; Region: COG3422 300267005569 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 300267005570 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 300267005571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267005572 active site 300267005573 phosphorylation site [posttranslational modification] 300267005574 intermolecular recognition site; other site 300267005575 dimerization interface [polypeptide binding]; other site 300267005576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267005577 DNA binding site [nucleotide binding] 300267005578 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 300267005579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267005580 dimerization interface [polypeptide binding]; other site 300267005581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267005582 dimer interface [polypeptide binding]; other site 300267005583 phosphorylation site [posttranslational modification] 300267005584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267005585 ATP binding site [chemical binding]; other site 300267005586 Mg2+ binding site [ion binding]; other site 300267005587 G-X-G motif; other site 300267005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267005589 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267005590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267005591 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 300267005592 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 300267005593 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 300267005594 metal ion-dependent adhesion site (MIDAS); other site 300267005595 Protein phosphatase 2C; Region: PP2C_2; pfam13672 300267005596 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 300267005597 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 300267005598 putative chaperone; Provisional; Region: PRK11678 300267005599 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 300267005600 nucleotide binding site [chemical binding]; other site 300267005601 putative NEF/HSP70 interaction site [polypeptide binding]; other site 300267005602 SBD interface [polypeptide binding]; other site 300267005603 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 300267005604 AlkA N-terminal domain; Region: AlkA_N; smart01009 300267005605 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 300267005606 minor groove reading motif; other site 300267005607 helix-hairpin-helix signature motif; other site 300267005608 substrate binding pocket [chemical binding]; other site 300267005609 active site 300267005610 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 300267005611 ATP-binding site [chemical binding]; other site 300267005612 Sugar specificity; other site 300267005613 Pyrimidine base specificity; other site 300267005614 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 300267005615 trimer interface [polypeptide binding]; other site 300267005616 active site 300267005617 putative assembly protein; Provisional; Region: PRK10833 300267005618 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 300267005619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 300267005620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267005621 non-specific DNA binding site [nucleotide binding]; other site 300267005622 salt bridge; other site 300267005623 sequence-specific DNA binding site [nucleotide binding]; other site 300267005624 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 300267005625 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 300267005626 FOG: CBS domain [General function prediction only]; Region: COG0517 300267005627 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 300267005628 Transporter associated domain; Region: CorC_HlyC; smart01091 300267005629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005630 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005631 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005632 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005633 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 300267005634 active site 300267005635 tetramer interface; other site 300267005636 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 300267005637 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 300267005638 NAD binding site [chemical binding]; other site 300267005639 substrate binding site [chemical binding]; other site 300267005640 homodimer interface [polypeptide binding]; other site 300267005641 active site 300267005642 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 300267005643 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 300267005644 NADP binding site [chemical binding]; other site 300267005645 active site 300267005646 putative substrate binding site [chemical binding]; other site 300267005647 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 300267005648 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 300267005649 substrate binding site; other site 300267005650 tetramer interface; other site 300267005651 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 300267005652 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 300267005653 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 300267005654 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 300267005655 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 300267005656 active site 300267005657 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 300267005658 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 300267005659 Ligand binding site; other site 300267005660 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 300267005661 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 300267005662 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 300267005663 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 300267005664 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 300267005665 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 300267005666 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 300267005667 chain length determinant protein WzzB; Provisional; Region: PRK15471 300267005668 Chain length determinant protein; Region: Wzz; pfam02706 300267005669 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 300267005670 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 300267005671 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 300267005672 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 300267005673 metal binding site [ion binding]; metal-binding site 300267005674 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 300267005675 substrate binding site [chemical binding]; other site 300267005676 glutamase interaction surface [polypeptide binding]; other site 300267005677 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 300267005678 catalytic residues [active] 300267005679 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 300267005680 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 300267005681 putative active site [active] 300267005682 oxyanion strand; other site 300267005683 catalytic triad [active] 300267005684 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 300267005685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267005686 active site 300267005687 motif I; other site 300267005688 motif II; other site 300267005689 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 300267005690 putative active site pocket [active] 300267005691 4-fold oligomerization interface [polypeptide binding]; other site 300267005692 metal binding residues [ion binding]; metal-binding site 300267005693 3-fold/trimer interface [polypeptide binding]; other site 300267005694 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 300267005695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267005696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267005697 homodimer interface [polypeptide binding]; other site 300267005698 catalytic residue [active] 300267005699 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 300267005700 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 300267005701 NAD binding site [chemical binding]; other site 300267005702 dimerization interface [polypeptide binding]; other site 300267005703 product binding site; other site 300267005704 substrate binding site [chemical binding]; other site 300267005705 zinc binding site [ion binding]; other site 300267005706 catalytic residues [active] 300267005707 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 300267005708 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 300267005709 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 300267005710 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 300267005711 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 300267005712 putative NAD(P) binding site [chemical binding]; other site 300267005713 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 300267005714 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267005715 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267005716 HTH-like domain; Region: HTH_21; pfam13276 300267005717 Integrase core domain; Region: rve; pfam00665 300267005718 Integrase core domain; Region: rve_3; pfam13683 300267005719 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267005720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005721 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 300267005722 CPxP motif; other site 300267005723 exonuclease I; Provisional; Region: sbcB; PRK11779 300267005724 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 300267005725 active site 300267005726 catalytic site [active] 300267005727 substrate binding site [chemical binding]; other site 300267005728 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 300267005729 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005731 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005732 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005733 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 300267005734 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 300267005735 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 300267005736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005737 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005738 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005739 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005740 Predicted membrane protein [Function unknown]; Region: COG1289 300267005741 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 300267005742 hypothetical protein; Provisional; Region: PRK05423 300267005743 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005744 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 300267005745 homotrimer interface [polypeptide binding]; other site 300267005746 Walker A motif; other site 300267005747 GTP binding site [chemical binding]; other site 300267005748 Walker B motif; other site 300267005749 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 300267005750 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 300267005751 putative dimer interface [polypeptide binding]; other site 300267005752 active site pocket [active] 300267005753 putative cataytic base [active] 300267005754 L,D-transpeptidase; Provisional; Region: PRK10190 300267005755 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 300267005756 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 300267005757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267005758 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 300267005759 putative dimerization interface [polypeptide binding]; other site 300267005760 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 300267005761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267005762 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 300267005763 putative substrate binding site [chemical binding]; other site 300267005764 dimerization interface [polypeptide binding]; other site 300267005765 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 300267005766 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 300267005767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005768 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005769 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005770 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005771 AMP nucleosidase; Provisional; Region: PRK08292 300267005772 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 300267005773 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 300267005774 shikimate transporter; Provisional; Region: PRK09952 300267005775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267005776 putative substrate translocation pore; other site 300267005777 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 300267005778 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 300267005779 putative protease; Provisional; Region: PRK15452 300267005780 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 300267005781 lipid kinase; Reviewed; Region: PRK13054 300267005782 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 300267005783 ATP-NAD kinase; Region: NAD_kinase; cl01255 300267005784 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 300267005785 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 300267005786 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267005787 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 300267005788 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 300267005789 putative NAD(P) binding site [chemical binding]; other site 300267005790 catalytic Zn binding site [ion binding]; other site 300267005791 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 300267005792 active site 300267005793 P-loop; other site 300267005794 phosphorylation site [posttranslational modification] 300267005795 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005797 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005798 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005799 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 300267005800 intersubunit interface [polypeptide binding]; other site 300267005801 active site 300267005802 zinc binding site [ion binding]; other site 300267005803 Na+ binding site [ion binding]; other site 300267005804 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 300267005805 putative active site; other site 300267005806 catalytic residue [active] 300267005807 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 300267005808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267005809 putative substrate translocation pore; other site 300267005810 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 300267005811 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 300267005812 substrate binding site [chemical binding]; other site 300267005813 ATP binding site [chemical binding]; other site 300267005814 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 300267005815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267005816 DNA-binding site [nucleotide binding]; DNA binding site 300267005817 UTRA domain; Region: UTRA; pfam07702 300267005818 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 300267005819 dimer interface [polypeptide binding]; other site 300267005820 substrate binding site [chemical binding]; other site 300267005821 ATP binding site [chemical binding]; other site 300267005822 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 300267005823 substrate binding site [chemical binding]; other site 300267005824 multimerization interface [polypeptide binding]; other site 300267005825 ATP binding site [chemical binding]; other site 300267005826 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 300267005827 putative metal binding site [ion binding]; other site 300267005828 putative homodimer interface [polypeptide binding]; other site 300267005829 putative homotetramer interface [polypeptide binding]; other site 300267005830 putative homodimer-homodimer interface [polypeptide binding]; other site 300267005831 putative allosteric switch controlling residues; other site 300267005832 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 300267005833 Predicted integral membrane protein [Function unknown]; Region: COG5455 300267005834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005835 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005836 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005837 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005839 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005840 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005841 Outer membrane usher protein; Region: Usher; pfam00577 300267005842 PapC C-terminal domain; Region: PapC_C; pfam13953 300267005843 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005845 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005846 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005848 Transposase; Region: HTH_Tnp_1; pfam01527 300267005849 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 300267005850 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 300267005851 active site residue [active] 300267005852 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 300267005853 putative acyl-acceptor binding pocket; other site 300267005854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267005855 Transposase; Region: HTH_Tnp_1; cl17663 300267005856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267005857 putative substrate translocation pore; other site 300267005858 secY/secA suppressor protein; Provisional; Region: PRK11467 300267005859 lipoprotein; Provisional; Region: PRK10175 300267005860 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 300267005861 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 300267005862 Ligand binding site; other site 300267005863 DXD motif; other site 300267005864 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 300267005865 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 300267005866 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 300267005867 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 300267005868 putative active site [active] 300267005869 catalytic site [active] 300267005870 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 300267005871 putative active site [active] 300267005872 catalytic site [active] 300267005873 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 300267005874 putative ADP-ribose binding site [chemical binding]; other site 300267005875 putative active site [active] 300267005876 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 300267005877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005878 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005879 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005880 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005881 hypothetical protein; Provisional; Region: PRK03757 300267005882 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 300267005883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005884 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005885 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005886 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267005887 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 300267005888 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 300267005889 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 300267005890 active site 300267005891 P-loop; other site 300267005892 phosphorylation site [posttranslational modification] 300267005893 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 300267005894 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 300267005895 putative substrate binding site [chemical binding]; other site 300267005896 putative ATP binding site [chemical binding]; other site 300267005897 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 300267005898 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 300267005899 active site 300267005900 phosphorylation site [posttranslational modification] 300267005901 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 300267005902 dimerization domain swap beta strand [polypeptide binding]; other site 300267005903 regulatory protein interface [polypeptide binding]; other site 300267005904 active site 300267005905 regulatory phosphorylation site [posttranslational modification]; other site 300267005906 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005908 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005909 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005910 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 300267005911 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 300267005912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267005913 substrate binding pocket [chemical binding]; other site 300267005914 membrane-bound complex binding site; other site 300267005915 hinge residues; other site 300267005916 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 300267005917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267005918 dimer interface [polypeptide binding]; other site 300267005919 conserved gate region; other site 300267005920 putative PBP binding loops; other site 300267005921 ABC-ATPase subunit interface; other site 300267005922 aminopeptidase N; Provisional; Region: pepN; PRK14015 300267005923 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 300267005924 active site 300267005925 Zn binding site [ion binding]; other site 300267005926 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 300267005927 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 300267005928 active site 300267005929 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 300267005930 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 300267005931 putative dimer interface [polypeptide binding]; other site 300267005932 putative anticodon binding site; other site 300267005933 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 300267005934 homodimer interface [polypeptide binding]; other site 300267005935 motif 1; other site 300267005936 motif 2; other site 300267005937 active site 300267005938 motif 3; other site 300267005939 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 300267005940 trimer interface [polypeptide binding]; other site 300267005941 eyelet of channel; other site 300267005942 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 300267005943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267005944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267005945 homodimer interface [polypeptide binding]; other site 300267005946 catalytic residue [active] 300267005947 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 300267005948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 300267005949 Peptidase M15; Region: Peptidase_M15_3; cl01194 300267005950 murein L,D-transpeptidase; Provisional; Region: PRK10594 300267005951 K+ potassium transporter; Region: K_trans; cl15781 300267005952 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 300267005953 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 300267005954 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267005955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267005956 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267005957 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267005958 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 300267005959 MukB N-terminal; Region: MukB; pfam04310 300267005960 Trypsin-like peptidase domain; Region: Trypsin_2; cl19303 300267005961 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 300267005962 condesin subunit E; Provisional; Region: PRK05256 300267005963 condesin subunit F; Provisional; Region: PRK05260 300267005964 Methyltransferase domain; Region: Methyltransf_31; pfam13847 300267005965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267005966 S-adenosylmethionine binding site [chemical binding]; other site 300267005967 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 300267005968 putative active site [active] 300267005969 hypothetical protein; Provisional; Region: PRK10593 300267005970 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 300267005971 Ligand binding site; other site 300267005972 oligomer interface; other site 300267005973 hypothetical protein; Provisional; Region: PRK11827 300267005974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 300267005975 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 300267005976 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 300267005977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267005978 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 300267005979 Walker A/P-loop; other site 300267005980 ATP binding site [chemical binding]; other site 300267005981 Q-loop/lid; other site 300267005982 ABC transporter signature motif; other site 300267005983 Walker B; other site 300267005984 D-loop; other site 300267005985 H-loop/switch region; other site 300267005986 ComEC family competence protein; Provisional; Region: PRK11539 300267005987 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 300267005988 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 300267005989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 300267005990 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 300267005991 dimer interface [polypeptide binding]; other site 300267005992 DNA binding site [nucleotide binding] 300267005993 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 300267005994 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 300267005995 RNA binding site [nucleotide binding]; other site 300267005996 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 300267005997 RNA binding site [nucleotide binding]; other site 300267005998 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 300267005999 RNA binding site [nucleotide binding]; other site 300267006000 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 300267006001 RNA binding site [nucleotide binding]; other site 300267006002 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 300267006003 RNA binding site [nucleotide binding]; other site 300267006004 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 300267006005 RNA binding site [nucleotide binding]; other site 300267006006 cytidylate kinase; Provisional; Region: cmk; PRK00023 300267006007 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 300267006008 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 300267006009 active site 300267006010 CMP-binding site; other site 300267006011 The sites determining sugar specificity; other site 300267006012 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 300267006013 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267006014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267006015 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267006016 HTH-like domain; Region: HTH_21; pfam13276 300267006017 Integrase core domain; Region: rve; pfam00665 300267006018 Integrase core domain; Region: rve_3; pfam13683 300267006019 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267006020 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267006021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267006022 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 300267006023 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 300267006024 hinge; other site 300267006025 active site 300267006026 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 300267006027 homodimer interface [polypeptide binding]; other site 300267006028 substrate-cofactor binding pocket; other site 300267006029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267006030 catalytic residue [active] 300267006031 Predicted membrane protein [Function unknown]; Region: COG2323 300267006032 formate transporter; Provisional; Region: PRK10805 300267006033 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 300267006034 Pyruvate formate lyase 1; Region: PFL1; cd01678 300267006035 coenzyme A binding site [chemical binding]; other site 300267006036 active site 300267006037 catalytic residues [active] 300267006038 glycine loop; other site 300267006039 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 300267006040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267006041 FeS/SAM binding site; other site 300267006042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006043 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006044 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006045 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267006047 Transposase; Region: HTH_Tnp_1; pfam01527 300267006048 putative MFS family transporter protein; Provisional; Region: PRK03633 300267006049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267006050 putative substrate translocation pore; other site 300267006051 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 300267006052 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 300267006053 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 300267006054 putative [Fe4-S4] binding site [ion binding]; other site 300267006055 putative molybdopterin cofactor binding site [chemical binding]; other site 300267006056 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 300267006057 putative molybdopterin cofactor binding site; other site 300267006058 seryl-tRNA synthetase; Provisional; Region: PRK05431 300267006059 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 300267006060 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 300267006061 dimer interface [polypeptide binding]; other site 300267006062 active site 300267006063 motif 1; other site 300267006064 motif 2; other site 300267006065 motif 3; other site 300267006066 recombination factor protein RarA; Reviewed; Region: PRK13342 300267006067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267006068 Walker A motif; other site 300267006069 ATP binding site [chemical binding]; other site 300267006070 Walker B motif; other site 300267006071 arginine finger; other site 300267006072 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 300267006073 periplasmic chaperone LolA; Region: lolA; TIGR00547 300267006074 DNA translocase FtsK; Provisional; Region: PRK10263 300267006075 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 300267006076 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 300267006077 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 300267006078 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 300267006079 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 300267006080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 300267006081 putative DNA binding site [nucleotide binding]; other site 300267006082 putative Zn2+ binding site [ion binding]; other site 300267006083 AsnC family; Region: AsnC_trans_reg; pfam01037 300267006084 thioredoxin reductase; Provisional; Region: PRK10262 300267006085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267006086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267006087 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 300267006088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267006089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267006090 Walker A/P-loop; other site 300267006091 ATP binding site [chemical binding]; other site 300267006092 Q-loop/lid; other site 300267006093 ABC transporter signature motif; other site 300267006094 Walker B; other site 300267006095 D-loop; other site 300267006096 H-loop/switch region; other site 300267006097 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 300267006098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 300267006099 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 300267006100 Walker A/P-loop; other site 300267006101 ATP binding site [chemical binding]; other site 300267006102 Q-loop/lid; other site 300267006103 ABC transporter signature motif; other site 300267006104 Walker B; other site 300267006105 D-loop; other site 300267006106 H-loop/switch region; other site 300267006107 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 300267006108 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 300267006109 rRNA binding site [nucleotide binding]; other site 300267006110 predicted 30S ribosome binding site; other site 300267006111 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 300267006112 Clp amino terminal domain; Region: Clp_N; pfam02861 300267006113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267006114 Walker A motif; other site 300267006115 ATP binding site [chemical binding]; other site 300267006116 Walker B motif; other site 300267006117 arginine finger; other site 300267006118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267006119 Walker A motif; other site 300267006120 ATP binding site [chemical binding]; other site 300267006121 Walker B motif; other site 300267006122 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 300267006123 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 300267006124 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 300267006125 DNA-binding site [nucleotide binding]; DNA binding site 300267006126 RNA-binding motif; other site 300267006127 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 300267006128 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 300267006129 Walker A/P-loop; other site 300267006130 ATP binding site [chemical binding]; other site 300267006131 Q-loop/lid; other site 300267006132 ABC transporter signature motif; other site 300267006133 Walker B; other site 300267006134 D-loop; other site 300267006135 H-loop/switch region; other site 300267006136 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 300267006137 FtsX-like permease family; Region: FtsX; pfam02687 300267006138 macrolide transporter subunit MacA; Provisional; Region: PRK11578 300267006139 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 300267006140 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267006141 Protein of unknown function (DUF535); Region: DUF535; pfam04393 300267006142 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 300267006143 AAA domain; Region: AAA_21; pfam13304 300267006144 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 300267006145 putative active site [active] 300267006146 putative metal-binding site [ion binding]; other site 300267006147 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006149 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006150 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006151 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 300267006152 amphipathic channel; other site 300267006153 Asn-Pro-Ala signature motifs; other site 300267006154 Predicted membrane protein [Function unknown]; Region: COG2431 300267006155 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 300267006156 cubane metal cluster [ion binding]; other site 300267006157 hybrid metal cluster; other site 300267006158 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 300267006159 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 300267006160 FAD binding pocket [chemical binding]; other site 300267006161 FAD binding motif [chemical binding]; other site 300267006162 phosphate binding motif [ion binding]; other site 300267006163 beta-alpha-beta structure motif; other site 300267006164 NAD binding pocket [chemical binding]; other site 300267006165 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 300267006166 catalytic loop [active] 300267006167 iron binding site [ion binding]; other site 300267006168 pyruvate dehydrogenase; Provisional; Region: PRK09124 300267006169 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 300267006170 PYR/PP interface [polypeptide binding]; other site 300267006171 dimer interface [polypeptide binding]; other site 300267006172 tetramer interface [polypeptide binding]; other site 300267006173 TPP binding site [chemical binding]; other site 300267006174 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 300267006175 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 300267006176 TPP-binding site [chemical binding]; other site 300267006177 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 300267006178 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 300267006179 tetramer interface [polypeptide binding]; other site 300267006180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267006181 catalytic residue [active] 300267006182 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 300267006183 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 300267006184 putative NAD(P) binding site [chemical binding]; other site 300267006185 putative active site [active] 300267006186 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 300267006187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 300267006188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 300267006189 NAD(P) binding site [chemical binding]; other site 300267006190 active site 300267006191 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 300267006192 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 300267006193 amidase catalytic site [active] 300267006194 Zn binding residues [ion binding]; other site 300267006195 substrate binding site [chemical binding]; other site 300267006196 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 300267006197 hypothetical protein; Provisional; Region: PRK02877 300267006198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006199 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006200 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006201 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006202 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006204 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006205 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006207 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006208 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006209 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006210 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 300267006211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267006212 Walker A/P-loop; other site 300267006213 ATP binding site [chemical binding]; other site 300267006214 Q-loop/lid; other site 300267006215 ABC transporter signature motif; other site 300267006216 Walker B; other site 300267006217 D-loop; other site 300267006218 H-loop/switch region; other site 300267006219 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 300267006220 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267006221 substrate binding pocket [chemical binding]; other site 300267006222 membrane-bound complex binding site; other site 300267006223 hinge residues; other site 300267006224 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 300267006225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267006226 dimer interface [polypeptide binding]; other site 300267006227 conserved gate region; other site 300267006228 putative PBP binding loops; other site 300267006229 ABC-ATPase subunit interface; other site 300267006230 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 300267006231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267006232 dimer interface [polypeptide binding]; other site 300267006233 conserved gate region; other site 300267006234 putative PBP binding loops; other site 300267006235 ABC-ATPase subunit interface; other site 300267006236 HTH-like domain; Region: HTH_21; pfam13276 300267006237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267006238 Integrase core domain; Region: rve; pfam00665 300267006239 Integrase core domain; Region: rve_3; pfam13683 300267006240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267006241 Transposase; Region: HTH_Tnp_1; pfam01527 300267006242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006243 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006244 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006245 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 300267006246 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 300267006247 ORF6N domain; Region: ORF6N; pfam10543 300267006248 Phage anti-repressor protein [Transcription]; Region: COG3561 300267006249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 300267006250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267006251 salt bridge; other site 300267006252 non-specific DNA binding site [nucleotide binding]; other site 300267006253 sequence-specific DNA binding site [nucleotide binding]; other site 300267006254 NinB protein; Region: NinB; pfam05772 300267006255 HTH-like domain; Region: HTH_21; pfam13276 300267006256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267006257 Integrase core domain; Region: rve; pfam00665 300267006258 Integrase core domain; Region: rve_3; pfam13683 300267006259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267006260 Transposase; Region: HTH_Tnp_1; pfam01527 300267006261 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 300267006262 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 300267006263 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; pfam02899 300267006264 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 300267006265 dimer interface [polypeptide binding]; other site 300267006266 active site 300267006267 Int/Topo IB signature motif; other site 300267006268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 300267006269 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 300267006270 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 300267006271 DNA gyrase subunit A; Validated; Region: PRK05560 300267006272 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 300267006273 CAP-like domain; other site 300267006274 active site 300267006275 primary dimer interface [polypeptide binding]; other site 300267006276 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 300267006277 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 300267006278 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 300267006279 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 300267006280 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 300267006281 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 300267006282 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 300267006283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267006284 S-adenosylmethionine binding site [chemical binding]; other site 300267006285 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 300267006286 ATP cone domain; Region: ATP-cone; pfam03477 300267006287 Class I ribonucleotide reductase; Region: RNR_I; cd01679 300267006288 active site 300267006289 dimer interface [polypeptide binding]; other site 300267006290 catalytic residues [active] 300267006291 effector binding site; other site 300267006292 R2 peptide binding site; other site 300267006293 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 300267006294 dimer interface [polypeptide binding]; other site 300267006295 putative radical transfer pathway; other site 300267006296 diiron center [ion binding]; other site 300267006297 tyrosyl radical; other site 300267006298 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 300267006299 catalytic loop [active] 300267006300 iron binding site [ion binding]; other site 300267006301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267006302 putative substrate translocation pore; other site 300267006303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 300267006304 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 300267006305 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 300267006306 active site 300267006307 catalytic site [active] 300267006308 metal binding site [ion binding]; metal-binding site 300267006309 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 300267006310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267006311 putative substrate translocation pore; other site 300267006312 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 300267006313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267006314 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 300267006315 FAD binding domain; Region: FAD_binding_2; pfam00890 300267006316 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 300267006317 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 300267006318 Cysteine-rich domain; Region: CCG; pfam02754 300267006319 Cysteine-rich domain; Region: CCG; pfam02754 300267006320 hypothetical protein; Provisional; Region: PRK09956 300267006321 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 300267006322 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 300267006323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006324 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006325 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006326 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006328 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006329 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006330 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006331 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 300267006332 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 300267006333 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 300267006334 putative active site [active] 300267006335 putative catalytic site [active] 300267006336 putative Zn binding site [ion binding]; other site 300267006337 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 300267006338 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 300267006339 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 300267006340 signal transduction protein PmrD; Provisional; Region: PRK15450 300267006341 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 300267006342 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 300267006343 acyl-activating enzyme (AAE) consensus motif; other site 300267006344 putative AMP binding site [chemical binding]; other site 300267006345 putative active site [active] 300267006346 putative CoA binding site [chemical binding]; other site 300267006347 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 300267006348 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 300267006349 active site 300267006350 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 300267006351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 300267006352 substrate binding site [chemical binding]; other site 300267006353 oxyanion hole (OAH) forming residues; other site 300267006354 trimer interface [polypeptide binding]; other site 300267006355 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 300267006356 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 300267006357 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 300267006358 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 300267006359 dimer interface [polypeptide binding]; other site 300267006360 tetramer interface [polypeptide binding]; other site 300267006361 PYR/PP interface [polypeptide binding]; other site 300267006362 TPP binding site [chemical binding]; other site 300267006363 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 300267006364 TPP-binding site; other site 300267006365 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 300267006366 isochorismate synthases; Region: isochor_syn; TIGR00543 300267006367 hypothetical protein; Provisional; Region: PRK10404 300267006368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267006369 Coenzyme A binding pocket [chemical binding]; other site 300267006370 ribonuclease BN; Region: true_RNase_BN; TIGR02649 300267006371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006372 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006373 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006374 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006376 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006377 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006379 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006380 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006381 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006382 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 300267006383 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 300267006384 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 300267006385 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 300267006386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 300267006387 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 300267006388 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 300267006389 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 300267006390 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 300267006391 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 300267006392 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 300267006393 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 300267006394 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267006395 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 300267006396 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 300267006397 NADH dehydrogenase subunit G; Validated; Region: PRK08166 300267006398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 300267006399 catalytic loop [active] 300267006400 iron binding site [ion binding]; other site 300267006401 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 300267006402 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 300267006403 [4Fe-4S] binding site [ion binding]; other site 300267006404 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 300267006405 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 300267006406 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 300267006407 SLBB domain; Region: SLBB; pfam10531 300267006408 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 300267006409 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 300267006410 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 300267006411 putative dimer interface [polypeptide binding]; other site 300267006412 [2Fe-2S] cluster binding site [ion binding]; other site 300267006413 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 300267006414 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 300267006415 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 300267006416 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 300267006417 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 300267006418 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 300267006419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267006420 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 300267006421 putative dimerization interface [polypeptide binding]; other site 300267006422 aminotransferase AlaT; Validated; Region: PRK09265 300267006423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267006424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267006425 homodimer interface [polypeptide binding]; other site 300267006426 catalytic residue [active] 300267006427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 300267006428 Zn2+ binding site [ion binding]; other site 300267006429 Mg2+ binding site [ion binding]; other site 300267006430 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 300267006431 transmembrane helices; other site 300267006432 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 300267006433 TrkA-C domain; Region: TrkA_C; pfam02080 300267006434 TrkA-C domain; Region: TrkA_C; pfam02080 300267006435 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 300267006436 putative phosphatase; Provisional; Region: PRK11587 300267006437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267006438 active site 300267006439 motif I; other site 300267006440 motif II; other site 300267006441 hypothetical protein; Validated; Region: PRK05445 300267006442 hypothetical protein; Provisional; Region: PRK01816 300267006443 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 300267006444 phosphate acetyltransferase; Reviewed; Region: PRK05632 300267006445 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 300267006446 DRTGG domain; Region: DRTGG; pfam07085 300267006447 phosphate acetyltransferase; Region: pta; TIGR00651 300267006448 hypothetical protein; Provisional; Region: PRK11588 300267006449 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 300267006450 nudix motif; other site 300267006451 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 300267006452 active site 300267006453 metal binding site [ion binding]; metal-binding site 300267006454 homotetramer interface [polypeptide binding]; other site 300267006455 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 300267006456 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 300267006457 C-terminal domain interface [polypeptide binding]; other site 300267006458 GSH binding site (G-site) [chemical binding]; other site 300267006459 dimer interface [polypeptide binding]; other site 300267006460 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 300267006461 N-terminal domain interface [polypeptide binding]; other site 300267006462 putative dimer interface [polypeptide binding]; other site 300267006463 active site 300267006464 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 300267006465 homooctamer interface [polypeptide binding]; other site 300267006466 active site 300267006467 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 300267006468 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 300267006469 putative NAD(P) binding site [chemical binding]; other site 300267006470 putative active site [active] 300267006471 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 300267006472 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 300267006473 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 300267006474 Walker A/P-loop; other site 300267006475 ATP binding site [chemical binding]; other site 300267006476 Q-loop/lid; other site 300267006477 ABC transporter signature motif; other site 300267006478 Walker B; other site 300267006479 D-loop; other site 300267006480 H-loop/switch region; other site 300267006481 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 300267006482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267006483 dimer interface [polypeptide binding]; other site 300267006484 conserved gate region; other site 300267006485 putative PBP binding loops; other site 300267006486 ABC-ATPase subunit interface; other site 300267006487 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 300267006488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267006489 dimer interface [polypeptide binding]; other site 300267006490 conserved gate region; other site 300267006491 putative PBP binding loops; other site 300267006492 ABC-ATPase subunit interface; other site 300267006493 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 300267006494 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267006495 substrate binding pocket [chemical binding]; other site 300267006496 membrane-bound complex binding site; other site 300267006497 hinge residues; other site 300267006498 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 300267006499 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267006500 substrate binding pocket [chemical binding]; other site 300267006501 membrane-bound complex binding site; other site 300267006502 hinge residues; other site 300267006503 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 300267006504 amidophosphoribosyltransferase; Provisional; Region: PRK09246 300267006505 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 300267006506 active site 300267006507 tetramer interface [polypeptide binding]; other site 300267006508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 300267006509 active site 300267006510 colicin V production protein; Provisional; Region: PRK10845 300267006511 cell division protein DedD; Provisional; Region: PRK11633 300267006512 Sporulation related domain; Region: SPOR; pfam05036 300267006513 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 300267006514 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 300267006515 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 300267006516 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 300267006517 hypothetical protein; Provisional; Region: PRK10847 300267006518 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 300267006519 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 300267006520 dimerization interface 3.5A [polypeptide binding]; other site 300267006521 active site 300267006522 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 300267006523 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 300267006524 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 300267006525 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 300267006526 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 300267006527 ligand binding site [chemical binding]; other site 300267006528 NAD binding site [chemical binding]; other site 300267006529 catalytic site [active] 300267006530 homodimer interface [polypeptide binding]; other site 300267006531 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 300267006532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267006533 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 300267006534 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 300267006535 dimer interface [polypeptide binding]; other site 300267006536 active site 300267006537 Uncharacterized conserved protein [Function unknown]; Region: COG4121 300267006538 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 300267006539 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 300267006540 YfcL protein; Region: YfcL; pfam08891 300267006541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 300267006542 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 300267006543 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 300267006544 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 300267006545 Tetramer interface [polypeptide binding]; other site 300267006546 active site 300267006547 FMN-binding site [chemical binding]; other site 300267006548 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 300267006549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267006550 S-adenosylmethionine binding site [chemical binding]; other site 300267006551 hypothetical protein; Provisional; Region: PRK04946 300267006552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 300267006553 Fimbrial protein; Region: Fimbrial; cl01416 300267006554 Fimbrial protein; Region: Fimbrial; cl01416 300267006555 Fimbrial protein; Region: Fimbrial; cl01416 300267006556 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 300267006557 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 300267006558 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 300267006559 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006561 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006562 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006563 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 300267006564 catalytic core [active] 300267006565 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 300267006566 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 300267006567 substrate binding site [chemical binding]; other site 300267006568 oxyanion hole (OAH) forming residues; other site 300267006569 trimer interface [polypeptide binding]; other site 300267006570 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 300267006571 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 300267006572 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 300267006573 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 300267006574 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 300267006575 dimer interface [polypeptide binding]; other site 300267006576 active site 300267006577 conserved hypothetical protein; Region: TIGR00743 300267006578 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 300267006579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006580 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006581 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006582 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006584 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006585 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006586 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 300267006587 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 300267006588 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006590 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006591 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006592 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006593 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 300267006594 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 300267006595 substrate binding [chemical binding]; other site 300267006596 active site 300267006597 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 300267006598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267006599 DNA binding site [nucleotide binding] 300267006600 domain linker motif; other site 300267006601 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 300267006602 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 300267006603 putative dimerization interface [polypeptide binding]; other site 300267006604 putative ligand binding site [chemical binding]; other site 300267006605 fructuronate transporter; Provisional; Region: PRK10034; cl15264 300267006606 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 300267006607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 300267006608 catalytic residue [active] 300267006609 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 300267006610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267006611 putative substrate translocation pore; other site 300267006612 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 300267006613 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 300267006614 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267006615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006616 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006617 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006618 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006619 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006621 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006622 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006624 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006625 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006626 putative CoA-transferase; Provisional; Region: PRK11430 300267006627 putative transporter YfdV; Provisional; Region: PRK09903 300267006628 oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254 300267006629 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 300267006630 PYR/PP interface [polypeptide binding]; other site 300267006631 dimer interface [polypeptide binding]; other site 300267006632 TPP binding site [chemical binding]; other site 300267006633 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 300267006634 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 300267006635 TPP-binding site; other site 300267006636 dimer interface [polypeptide binding]; other site 300267006637 formyl-coenzyme A transferase; Provisional; Region: PRK05398 300267006638 hypothetical protein; Provisional; Region: PRK10316 300267006639 YfdX protein; Region: YfdX; pfam10938 300267006640 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 300267006641 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 300267006642 putative acyl-acceptor binding pocket; other site 300267006643 aminotransferase; Validated; Region: PRK08175 300267006644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267006645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267006646 homodimer interface [polypeptide binding]; other site 300267006647 catalytic residue [active] 300267006648 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 300267006649 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 300267006650 GAF domain; Region: GAF; pfam01590 300267006651 Histidine kinase; Region: His_kinase; pfam06580 300267006652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267006653 ATP binding site [chemical binding]; other site 300267006654 Mg2+ binding site [ion binding]; other site 300267006655 G-X-G motif; other site 300267006656 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 300267006657 oligomer interface [polypeptide binding]; other site 300267006658 active site 300267006659 metal binding site [ion binding]; metal-binding site 300267006660 aminopeptidase; Provisional; Region: PRK09795 300267006661 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 300267006662 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 300267006663 active site 300267006664 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 300267006665 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 300267006666 active site 300267006667 P-loop; other site 300267006668 phosphorylation site [posttranslational modification] 300267006669 glucokinase; Provisional; Region: glk; PRK00292 300267006670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267006671 nucleotide binding site [chemical binding]; other site 300267006672 manganese transport protein MntH; Reviewed; Region: PRK00701 300267006673 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 300267006674 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267006675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267006676 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267006677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006678 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006679 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006680 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 300267006681 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 300267006682 Nucleoside recognition; Region: Gate; pfam07670 300267006683 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 300267006684 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 300267006685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267006686 salt bridge; other site 300267006687 non-specific DNA binding site [nucleotide binding]; other site 300267006688 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 300267006689 sequence-specific DNA binding site [nucleotide binding]; other site 300267006690 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 300267006691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 300267006692 Probable transposase; Region: OrfB_IS605; pfam01385 300267006693 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 300267006694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 300267006695 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 300267006696 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 300267006697 active site 300267006698 HIGH motif; other site 300267006699 KMSKS motif; other site 300267006700 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 300267006701 FlxA-like protein; Region: FlxA; pfam14282 300267006702 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 300267006703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 300267006704 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 300267006705 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 300267006706 nucleotide binding pocket [chemical binding]; other site 300267006707 K-X-D-G motif; other site 300267006708 catalytic site [active] 300267006709 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 300267006710 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 300267006711 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 300267006712 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 300267006713 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 300267006714 Dimer interface [polypeptide binding]; other site 300267006715 BRCT sequence motif; other site 300267006716 cell division protein ZipA; Provisional; Region: PRK03427 300267006717 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 300267006718 FtsZ protein binding site [polypeptide binding]; other site 300267006719 putative sulfate transport protein CysZ; Validated; Region: PRK04949 300267006720 cysteine synthase; Region: PLN02565 300267006721 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 300267006722 dimer interface [polypeptide binding]; other site 300267006723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267006724 catalytic residue [active] 300267006725 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 300267006726 dimerization domain swap beta strand [polypeptide binding]; other site 300267006727 regulatory protein interface [polypeptide binding]; other site 300267006728 active site 300267006729 regulatory phosphorylation site [posttranslational modification]; other site 300267006730 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 300267006731 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 300267006732 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 300267006733 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 300267006734 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 300267006735 HPr interaction site; other site 300267006736 glycerol kinase (GK) interaction site [polypeptide binding]; other site 300267006737 active site 300267006738 phosphorylation site [posttranslational modification] 300267006739 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 300267006740 dimer interface [polypeptide binding]; other site 300267006741 pyridoxal binding site [chemical binding]; other site 300267006742 ATP binding site [chemical binding]; other site 300267006743 hypothetical protein; Provisional; Region: PRK10318 300267006744 cysteine synthase; Region: PLN02565 300267006745 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 300267006746 dimer interface [polypeptide binding]; other site 300267006747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267006748 catalytic residue [active] 300267006749 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 300267006750 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 300267006751 Walker A/P-loop; other site 300267006752 ATP binding site [chemical binding]; other site 300267006753 Q-loop/lid; other site 300267006754 ABC transporter signature motif; other site 300267006755 Walker B; other site 300267006756 D-loop; other site 300267006757 H-loop/switch region; other site 300267006758 TOBE-like domain; Region: TOBE_3; pfam12857 300267006759 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 300267006760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267006761 dimer interface [polypeptide binding]; other site 300267006762 conserved gate region; other site 300267006763 putative PBP binding loops; other site 300267006764 ABC-ATPase subunit interface; other site 300267006765 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 300267006766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267006767 dimer interface [polypeptide binding]; other site 300267006768 conserved gate region; other site 300267006769 putative PBP binding loops; other site 300267006770 ABC-ATPase subunit interface; other site 300267006771 thiosulfate transporter subunit; Provisional; Region: PRK10852 300267006772 short chain dehydrogenase; Provisional; Region: PRK08226 300267006773 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 300267006774 NAD binding site [chemical binding]; other site 300267006775 homotetramer interface [polypeptide binding]; other site 300267006776 homodimer interface [polypeptide binding]; other site 300267006777 active site 300267006778 transcriptional regulator MurR; Provisional; Region: PRK15482 300267006779 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 300267006780 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 300267006781 putative active site [active] 300267006782 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 300267006783 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 300267006784 putative active site [active] 300267006785 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 300267006786 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 300267006787 active site turn [active] 300267006788 phosphorylation site [posttranslational modification] 300267006789 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 300267006790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006791 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006792 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006793 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 300267006794 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 300267006795 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 300267006796 putative acetyltransferase; Provisional; Region: PRK03624 300267006797 Uncharacterized conserved protein [Function unknown]; Region: COG3375 300267006798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267006799 Coenzyme A binding pocket [chemical binding]; other site 300267006800 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 300267006801 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 300267006802 active site 300267006803 metal binding site [ion binding]; metal-binding site 300267006804 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 300267006805 transcriptional regulator EutR; Provisional; Region: PRK10130 300267006806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267006807 carboxysome structural protein EutK; Provisional; Region: PRK15466 300267006808 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 300267006809 Hexamer interface [polypeptide binding]; other site 300267006810 Hexagonal pore residue; other site 300267006811 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 300267006812 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 300267006813 putative hexamer interface [polypeptide binding]; other site 300267006814 putative hexagonal pore; other site 300267006815 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 300267006816 putative hexamer interface [polypeptide binding]; other site 300267006817 putative hexagonal pore; other site 300267006818 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 300267006819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006820 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006821 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006823 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006824 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006825 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 300267006826 Malic enzyme, N-terminal domain; Region: malic; pfam00390 300267006827 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 300267006828 putative NAD(P) binding site [chemical binding]; other site 300267006829 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 300267006830 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006832 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006833 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006834 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 300267006835 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 300267006836 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 300267006837 dimer interface [polypeptide binding]; other site 300267006838 ADP-ribose binding site [chemical binding]; other site 300267006839 active site 300267006840 nudix motif; other site 300267006841 metal binding site [ion binding]; metal-binding site 300267006842 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 300267006843 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267006844 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 300267006845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267006846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267006847 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006849 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006850 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006851 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 300267006852 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 300267006853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267006854 dimerization interface [polypeptide binding]; other site 300267006855 Histidine kinase; Region: HisKA_3; pfam07730 300267006856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267006857 ATP binding site [chemical binding]; other site 300267006858 Mg2+ binding site [ion binding]; other site 300267006859 G-X-G motif; other site 300267006860 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 300267006861 MMPL family; Region: MMPL; cl14618 300267006862 MMPL family; Region: MMPL; cl14618 300267006863 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 300267006864 putative catalytic residues [active] 300267006865 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 300267006866 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 300267006867 metal binding site [ion binding]; metal-binding site 300267006868 dimer interface [polypeptide binding]; other site 300267006869 hypothetical protein; Provisional; Region: PRK13664 300267006870 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006872 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006873 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006874 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 300267006875 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 300267006876 Helicase; Region: Helicase_RecD; pfam05127 300267006877 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 300267006878 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 300267006879 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 300267006880 ATP binding site [chemical binding]; other site 300267006881 active site 300267006882 substrate binding site [chemical binding]; other site 300267006883 lipoprotein; Provisional; Region: PRK11679 300267006884 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 300267006885 dimer interface [polypeptide binding]; other site 300267006886 active site 300267006887 catalytic residue [active] 300267006888 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 300267006889 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 300267006890 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 300267006891 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 300267006892 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 300267006893 catalytic triad [active] 300267006894 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 300267006895 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267006896 hydrogenase 4 subunit B; Validated; Region: PRK06521 300267006897 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 300267006898 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 300267006899 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 300267006900 hydrogenase 4 subunit F; Validated; Region: PRK06458 300267006901 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 300267006902 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 300267006903 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 300267006904 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 300267006905 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 300267006906 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 300267006907 putative formate transporter; Provisional; Region: focB; PRK09713 300267006908 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 300267006909 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 300267006910 Peptidase family M48; Region: Peptidase_M48; cl12018 300267006911 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 300267006912 catalytic residues [active] 300267006913 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 300267006914 DNA replication initiation factor; Provisional; Region: PRK08084 300267006915 uracil transporter; Provisional; Region: PRK10720 300267006916 uracil-xanthine permease; Region: ncs2; TIGR00801 300267006917 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 300267006918 active site 300267006919 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 300267006920 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 300267006921 dimerization interface [polypeptide binding]; other site 300267006922 putative ATP binding site [chemical binding]; other site 300267006923 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 300267006924 active site 300267006925 substrate binding site [chemical binding]; other site 300267006926 cosubstrate binding site; other site 300267006927 catalytic site [active] 300267006928 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 300267006929 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 300267006930 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 300267006931 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 300267006932 domain interface [polypeptide binding]; other site 300267006933 active site 300267006934 catalytic site [active] 300267006935 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 300267006936 domain interface [polypeptide binding]; other site 300267006937 active site 300267006938 catalytic site [active] 300267006939 exopolyphosphatase; Provisional; Region: PRK10854 300267006940 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 300267006941 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006943 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006944 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006945 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006947 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006948 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006949 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 300267006950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267006951 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267006952 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267006953 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267006954 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 300267006955 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267006956 HTH-like domain; Region: HTH_21; pfam13276 300267006957 Integrase core domain; Region: rve; pfam00665 300267006958 Integrase core domain; Region: rve_3; pfam13683 300267006959 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267006960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267006961 GMP synthase; Reviewed; Region: guaA; PRK00074 300267006962 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 300267006963 AMP/PPi binding site [chemical binding]; other site 300267006964 candidate oxyanion hole; other site 300267006965 catalytic triad [active] 300267006966 potential glutamine specificity residues [chemical binding]; other site 300267006967 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 300267006968 ATP Binding subdomain [chemical binding]; other site 300267006969 Ligand Binding sites [chemical binding]; other site 300267006970 Dimerization subdomain; other site 300267006971 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 300267006972 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 300267006973 active site 300267006974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 300267006975 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 300267006976 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 300267006977 generic binding surface II; other site 300267006978 generic binding surface I; other site 300267006979 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 300267006980 GTP-binding protein Der; Reviewed; Region: PRK00093 300267006981 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 300267006982 G1 box; other site 300267006983 GTP/Mg2+ binding site [chemical binding]; other site 300267006984 Switch I region; other site 300267006985 G2 box; other site 300267006986 Switch II region; other site 300267006987 G3 box; other site 300267006988 G4 box; other site 300267006989 G5 box; other site 300267006990 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 300267006991 G1 box; other site 300267006992 GTP/Mg2+ binding site [chemical binding]; other site 300267006993 Switch I region; other site 300267006994 G2 box; other site 300267006995 G3 box; other site 300267006996 Switch II region; other site 300267006997 G4 box; other site 300267006998 G5 box; other site 300267006999 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 300267007000 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 300267007001 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 300267007002 Trp docking motif [polypeptide binding]; other site 300267007003 active site 300267007004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 300267007005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 300267007006 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 300267007007 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 300267007008 dimer interface [polypeptide binding]; other site 300267007009 motif 1; other site 300267007010 active site 300267007011 motif 2; other site 300267007012 motif 3; other site 300267007013 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 300267007014 anticodon binding site; other site 300267007015 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 300267007016 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 300267007017 cytoskeletal protein RodZ; Provisional; Region: PRK10856 300267007018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267007019 non-specific DNA binding site [nucleotide binding]; other site 300267007020 salt bridge; other site 300267007021 sequence-specific DNA binding site [nucleotide binding]; other site 300267007022 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 300267007023 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 300267007024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267007025 FeS/SAM binding site; other site 300267007026 Nucleoside diphosphate kinase; Region: NDK; pfam00334 300267007027 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 300267007028 active site 300267007029 multimer interface [polypeptide binding]; other site 300267007030 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 300267007031 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 300267007032 active site residue [active] 300267007033 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 300267007034 active site residue [active] 300267007035 SseB protein N-terminal domain; Region: SseB; pfam07179 300267007036 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 300267007037 SseB protein C-terminal domain; Region: SseB_C; pfam14581 300267007038 aminopeptidase B; Provisional; Region: PRK05015 300267007039 Peptidase; Region: DUF3663; pfam12404 300267007040 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 300267007041 interface (dimer of trimers) [polypeptide binding]; other site 300267007042 Substrate-binding/catalytic site; other site 300267007043 Zn-binding sites [ion binding]; other site 300267007044 hypothetical protein; Provisional; Region: PRK10721 300267007045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 300267007046 catalytic loop [active] 300267007047 iron binding site [ion binding]; other site 300267007048 chaperone protein HscA; Provisional; Region: hscA; PRK05183 300267007049 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 300267007050 nucleotide binding site [chemical binding]; other site 300267007051 putative NEF/HSP70 interaction site [polypeptide binding]; other site 300267007052 SBD interface [polypeptide binding]; other site 300267007053 co-chaperone HscB; Provisional; Region: hscB; PRK05014 300267007054 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 300267007055 HSP70 interaction site [polypeptide binding]; other site 300267007056 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 300267007057 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 300267007058 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 300267007059 trimerization site [polypeptide binding]; other site 300267007060 active site 300267007061 cysteine desulfurase; Provisional; Region: PRK14012 300267007062 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 300267007063 catalytic residue [active] 300267007064 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 300267007065 Rrf2 family protein; Region: rrf2_super; TIGR00738 300267007066 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 300267007067 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 300267007068 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 300267007069 active site 300267007070 dimerization interface [polypeptide binding]; other site 300267007071 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 300267007072 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 300267007073 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 300267007074 PRD domain; Region: PRD; pfam00874 300267007075 PRD domain; Region: PRD; pfam00874 300267007076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267007077 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 300267007078 putative substrate translocation pore; other site 300267007079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 300267007080 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007081 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007083 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007084 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007085 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 300267007086 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 300267007087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267007088 nucleotide binding site [chemical binding]; other site 300267007089 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 300267007090 dimer interface [polypeptide binding]; other site 300267007091 active site 300267007092 glycine-pyridoxal phosphate binding site [chemical binding]; other site 300267007093 folate binding site [chemical binding]; other site 300267007094 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 300267007095 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 300267007096 heme-binding site [chemical binding]; other site 300267007097 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 300267007098 FAD binding pocket [chemical binding]; other site 300267007099 FAD binding motif [chemical binding]; other site 300267007100 phosphate binding motif [ion binding]; other site 300267007101 beta-alpha-beta structure motif; other site 300267007102 NAD binding pocket [chemical binding]; other site 300267007103 Heme binding pocket [chemical binding]; other site 300267007104 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 300267007105 response regulator GlrR; Provisional; Region: PRK15115 300267007106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267007107 active site 300267007108 phosphorylation site [posttranslational modification] 300267007109 intermolecular recognition site; other site 300267007110 dimerization interface [polypeptide binding]; other site 300267007111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267007112 Walker A motif; other site 300267007113 ATP binding site [chemical binding]; other site 300267007114 Walker B motif; other site 300267007115 arginine finger; other site 300267007116 hypothetical protein; Provisional; Region: PRK10722 300267007117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 300267007118 HAMP domain; Region: HAMP; pfam00672 300267007119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267007120 dimer interface [polypeptide binding]; other site 300267007121 phosphorylation site [posttranslational modification] 300267007122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267007123 ATP binding site [chemical binding]; other site 300267007124 Mg2+ binding site [ion binding]; other site 300267007125 G-X-G motif; other site 300267007126 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 300267007127 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 300267007128 dimerization interface [polypeptide binding]; other site 300267007129 ATP binding site [chemical binding]; other site 300267007130 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 300267007131 dimerization interface [polypeptide binding]; other site 300267007132 ATP binding site [chemical binding]; other site 300267007133 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 300267007134 putative active site [active] 300267007135 catalytic triad [active] 300267007136 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 300267007137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267007138 substrate binding pocket [chemical binding]; other site 300267007139 membrane-bound complex binding site; other site 300267007140 hinge residues; other site 300267007141 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 300267007142 N-acetyl-D-glucosamine binding site [chemical binding]; other site 300267007143 catalytic residue [active] 300267007144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 300267007145 nucleoside/Zn binding site; other site 300267007146 dimer interface [polypeptide binding]; other site 300267007147 catalytic motif [active] 300267007148 hypothetical protein; Provisional; Region: PRK11590 300267007149 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 300267007150 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 300267007151 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 300267007152 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 300267007153 putative active site [active] 300267007154 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 300267007155 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 300267007156 catalytic residues [active] 300267007157 catalytic nucleophile [active] 300267007158 Presynaptic Site I dimer interface [polypeptide binding]; other site 300267007159 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 300267007160 Synaptic Flat tetramer interface [polypeptide binding]; other site 300267007161 Synaptic Site I dimer interface [polypeptide binding]; other site 300267007162 DNA binding site [nucleotide binding] 300267007163 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267007164 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 300267007165 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 300267007166 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267007167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007168 Transposase; Region: HTH_Tnp_1; pfam01527 300267007169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007170 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007171 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007172 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007173 lipoprotein; Provisional; Region: PRK11443 300267007174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007175 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007176 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007177 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 300267007178 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 300267007179 Chorismate mutase type II; Region: CM_2; cl00693 300267007180 prephenate dehydrogenase; Validated; Region: PRK08507 300267007181 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 300267007182 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 300267007183 Prephenate dehydratase; Region: PDT; pfam00800 300267007184 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 300267007185 putative L-Phe binding site [chemical binding]; other site 300267007186 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 300267007187 30S subunit binding site; other site 300267007188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007189 Transposase; Region: HTH_Tnp_1; pfam01527 300267007190 HTH-like domain; Region: HTH_21; pfam13276 300267007191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267007192 Integrase core domain; Region: rve; pfam00665 300267007193 Integrase core domain; Region: rve_3; pfam13683 300267007194 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 300267007195 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267007196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007197 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007198 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 300267007199 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 300267007200 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 300267007201 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 300267007202 RimM N-terminal domain; Region: RimM; pfam01782 300267007203 PRC-barrel domain; Region: PRC; pfam05239 300267007204 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 300267007205 signal recognition particle protein; Provisional; Region: PRK10867 300267007206 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 300267007207 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 300267007208 P loop; other site 300267007209 GTP binding site [chemical binding]; other site 300267007210 Signal peptide binding domain; Region: SRP_SPB; pfam02978 300267007211 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 300267007212 hypothetical protein; Provisional; Region: PRK11573 300267007213 Domain of unknown function DUF21; Region: DUF21; pfam01595 300267007214 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 300267007215 Transporter associated domain; Region: CorC_HlyC; smart01091 300267007216 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 300267007217 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 300267007218 dimer interface [polypeptide binding]; other site 300267007219 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 300267007220 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 300267007221 recombination and repair protein; Provisional; Region: PRK10869 300267007222 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 300267007223 Walker A/P-loop; other site 300267007224 ATP binding site [chemical binding]; other site 300267007225 Q-loop/lid; other site 300267007226 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 300267007227 Q-loop/lid; other site 300267007228 ABC transporter signature motif; other site 300267007229 Walker B; other site 300267007230 D-loop; other site 300267007231 H-loop/switch region; other site 300267007232 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 300267007233 hypothetical protein; Validated; Region: PRK01777 300267007234 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 300267007235 putative coenzyme Q binding site [chemical binding]; other site 300267007236 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 300267007237 SmpB-tmRNA interface; other site 300267007238 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 300267007239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007240 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007241 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007242 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007243 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 300267007244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267007245 nucleotide binding region [chemical binding]; other site 300267007246 ATP-binding site [chemical binding]; other site 300267007247 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 300267007248 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007250 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007251 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007252 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 300267007253 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 300267007254 active site 300267007255 hydrophilic channel; other site 300267007256 dimerization interface [polypeptide binding]; other site 300267007257 catalytic residues [active] 300267007258 active site lid [active] 300267007259 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 300267007260 Recombination protein O N terminal; Region: RecO_N; pfam11967 300267007261 Recombination protein O C terminal; Region: RecO_C; pfam02565 300267007262 GTPase Era; Reviewed; Region: era; PRK00089 300267007263 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 300267007264 G1 box; other site 300267007265 GTP/Mg2+ binding site [chemical binding]; other site 300267007266 Switch I region; other site 300267007267 G2 box; other site 300267007268 Switch II region; other site 300267007269 G3 box; other site 300267007270 G4 box; other site 300267007271 G5 box; other site 300267007272 KH domain; Region: KH_2; pfam07650 300267007273 ribonuclease III; Reviewed; Region: rnc; PRK00102 300267007274 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 300267007275 dimerization interface [polypeptide binding]; other site 300267007276 active site 300267007277 metal binding site [ion binding]; metal-binding site 300267007278 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 300267007279 dsRNA binding site [nucleotide binding]; other site 300267007280 signal peptidase I; Provisional; Region: PRK10861 300267007281 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 300267007282 Catalytic site [active] 300267007283 GTP-binding protein LepA; Provisional; Region: PRK05433 300267007284 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 300267007285 G1 box; other site 300267007286 putative GEF interaction site [polypeptide binding]; other site 300267007287 GTP/Mg2+ binding site [chemical binding]; other site 300267007288 Switch I region; other site 300267007289 G2 box; other site 300267007290 G3 box; other site 300267007291 Switch II region; other site 300267007292 G4 box; other site 300267007293 G5 box; other site 300267007294 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 300267007295 Elongation Factor G, domain II; Region: EFG_II; pfam14492 300267007296 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 300267007297 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 300267007298 SoxR reducing system protein RseC; Provisional; Region: PRK10862 300267007299 anti-sigma E factor; Provisional; Region: rseB; PRK09455 300267007300 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 300267007301 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 300267007302 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 300267007303 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 300267007304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 300267007305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 300267007306 DNA binding residues [nucleotide binding] 300267007307 L-aspartate oxidase; Provisional; Region: PRK09077 300267007308 L-aspartate oxidase; Provisional; Region: PRK06175 300267007309 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 300267007310 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 300267007311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267007312 S-adenosylmethionine binding site [chemical binding]; other site 300267007313 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 300267007314 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 300267007315 ATP binding site [chemical binding]; other site 300267007316 Mg++ binding site [ion binding]; other site 300267007317 motif III; other site 300267007318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267007319 nucleotide binding region [chemical binding]; other site 300267007320 ATP-binding site [chemical binding]; other site 300267007321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 300267007322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267007323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 300267007324 dimerization interface [polypeptide binding]; other site 300267007325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007326 Transposase; Region: HTH_Tnp_1; pfam01527 300267007327 LysE type translocator; Region: LysE; cl00565 300267007328 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 300267007329 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 300267007330 ligand binding site [chemical binding]; other site 300267007331 active site 300267007332 UGI interface [polypeptide binding]; other site 300267007333 catalytic site [active] 300267007334 putative methyltransferase; Provisional; Region: PRK10864 300267007335 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 300267007336 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 300267007337 thioredoxin 2; Provisional; Region: PRK10996 300267007338 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 300267007339 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 300267007340 catalytic residues [active] 300267007341 Uncharacterized conserved protein [Function unknown]; Region: COG3148 300267007342 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 300267007343 CoA binding domain; Region: CoA_binding_2; pfam13380 300267007344 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 300267007345 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 300267007346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 300267007347 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 300267007348 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 300267007349 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 300267007350 domain interface [polypeptide binding]; other site 300267007351 putative active site [active] 300267007352 catalytic site [active] 300267007353 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 300267007354 domain interface [polypeptide binding]; other site 300267007355 putative active site [active] 300267007356 catalytic site [active] 300267007357 lipoprotein; Provisional; Region: PRK10759 300267007358 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 300267007359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267007360 putative substrate translocation pore; other site 300267007361 protein disaggregation chaperone; Provisional; Region: PRK10865 300267007362 Clp amino terminal domain; Region: Clp_N; pfam02861 300267007363 Clp amino terminal domain; Region: Clp_N; pfam02861 300267007364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267007365 Walker A motif; other site 300267007366 ATP binding site [chemical binding]; other site 300267007367 Walker B motif; other site 300267007368 arginine finger; other site 300267007369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267007370 Walker A motif; other site 300267007371 ATP binding site [chemical binding]; other site 300267007372 Walker B motif; other site 300267007373 arginine finger; other site 300267007374 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 300267007375 hypothetical protein; Provisional; Region: PRK10723 300267007376 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 300267007377 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267007378 RNA binding surface [nucleotide binding]; other site 300267007379 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 300267007380 active site 300267007381 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 300267007382 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 300267007383 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267007384 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267007385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267007386 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 300267007387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 300267007388 HTH-like domain; Region: HTH_21; pfam13276 300267007389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267007390 Integrase core domain; Region: rve; pfam00665 300267007391 Integrase core domain; Region: rve_3; pfam13683 300267007392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007393 Transposase; Region: HTH_Tnp_1; pfam01527 300267007394 small toxic polypeptide; Provisional; Region: PRK09738 300267007395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007396 Transposase; Region: HTH_Tnp_1; cl17663 300267007397 HTH-like domain; Region: HTH_21; pfam13276 300267007398 Integrase core domain; Region: rve; pfam00665 300267007399 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007401 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007402 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007404 Transposase; Region: HTH_Tnp_1; cl17663 300267007405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007406 Transposase; Region: HTH_Tnp_1; cl17663 300267007407 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007409 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007410 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007411 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 300267007412 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267007413 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 300267007414 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 300267007415 DNA-binding site [nucleotide binding]; DNA binding site 300267007416 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 300267007417 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 300267007418 bacterial OsmY and nodulation domain; Region: BON; smart00749 300267007419 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 300267007420 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 300267007421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 300267007422 dimerization interface [polypeptide binding]; other site 300267007423 putative DNA binding site [nucleotide binding]; other site 300267007424 Transcriptional regulators [Transcription]; Region: MarR; COG1846 300267007425 putative Zn2+ binding site [ion binding]; other site 300267007426 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 300267007427 active site residue [active] 300267007428 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 300267007429 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 300267007430 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 300267007431 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 300267007432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007433 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007434 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007435 hypothetical protein; Provisional; Region: PRK10556 300267007436 hypothetical protein; Provisional; Region: PRK10132 300267007437 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 300267007438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267007439 DNA-binding site [nucleotide binding]; DNA binding site 300267007440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267007441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267007442 homodimer interface [polypeptide binding]; other site 300267007443 catalytic residue [active] 300267007444 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 300267007445 Uncharacterized conserved protein [Function unknown]; Region: COG2128 300267007446 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 300267007447 catalytic residues [active] 300267007448 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 300267007449 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 300267007450 dimer interface [polypeptide binding]; other site 300267007451 putative radical transfer pathway; other site 300267007452 diiron center [ion binding]; other site 300267007453 tyrosyl radical; other site 300267007454 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007456 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007457 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007458 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 300267007459 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 300267007460 Walker A/P-loop; other site 300267007461 ATP binding site [chemical binding]; other site 300267007462 Q-loop/lid; other site 300267007463 ABC transporter signature motif; other site 300267007464 Walker B; other site 300267007465 D-loop; other site 300267007466 H-loop/switch region; other site 300267007467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 300267007468 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 300267007469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267007470 dimer interface [polypeptide binding]; other site 300267007471 conserved gate region; other site 300267007472 putative PBP binding loops; other site 300267007473 ABC-ATPase subunit interface; other site 300267007474 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007476 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007477 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007478 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 300267007479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267007480 putative substrate translocation pore; other site 300267007481 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 300267007482 putative L-valine exporter; Provisional; Region: PRK10408 300267007483 transcriptional repressor MprA; Provisional; Region: PRK10870 300267007484 Transcriptional regulators [Transcription]; Region: MarR; COG1846 300267007485 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 300267007486 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 300267007487 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267007488 RNA ligase; Region: RNA_ligase; cl19220 300267007489 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 300267007490 Zn2+ binding site [ion binding]; other site 300267007491 Mg2+ binding site [ion binding]; other site 300267007492 AAA domain; Region: AAA_17; cl19128 300267007493 AAA domain; Region: AAA_33; pfam13671 300267007494 S-ribosylhomocysteinase; Provisional; Region: PRK02260 300267007495 glutamate--cysteine ligase; Provisional; Region: PRK02107 300267007496 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 300267007497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267007498 active site 300267007499 motif I; other site 300267007500 motif II; other site 300267007501 carbon storage regulator; Provisional; Region: PRK01712 300267007502 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 300267007503 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 300267007504 motif 1; other site 300267007505 active site 300267007506 motif 2; other site 300267007507 motif 3; other site 300267007508 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 300267007509 DHHA1 domain; Region: DHHA1; pfam02272 300267007510 recombination regulator RecX; Reviewed; Region: recX; PRK00117 300267007511 recombinase A; Provisional; Region: recA; PRK09354 300267007512 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 300267007513 hexamer interface [polypeptide binding]; other site 300267007514 Walker A motif; other site 300267007515 ATP binding site [chemical binding]; other site 300267007516 Walker B motif; other site 300267007517 hypothetical protein; Validated; Region: PRK03661 300267007518 murein hydrolase B; Provisional; Region: PRK10760 300267007519 lytic murein transglycosylase B; Region: MltB; TIGR02282 300267007520 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 300267007521 N-acetyl-D-glucosamine binding site [chemical binding]; other site 300267007522 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 300267007523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007524 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007525 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007526 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 300267007527 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 300267007528 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 300267007529 putative NAD(P) binding site [chemical binding]; other site 300267007530 active site 300267007531 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 300267007532 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 300267007533 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 300267007534 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267007535 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 300267007536 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 300267007537 putative active site [active] 300267007538 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 300267007539 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 300267007540 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 300267007541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267007542 Walker A motif; other site 300267007543 ATP binding site [chemical binding]; other site 300267007544 Walker B motif; other site 300267007545 arginine finger; other site 300267007546 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 300267007547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 300267007548 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 300267007549 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 300267007550 iron binding site [ion binding]; other site 300267007551 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 300267007552 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267007553 Acylphosphatase; Region: Acylphosphatase; pfam00708 300267007554 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 300267007555 HypF finger; Region: zf-HYPF; pfam07503 300267007556 HypF finger; Region: zf-HYPF; pfam07503 300267007557 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 300267007558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 300267007559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267007560 DNA binding site [nucleotide binding] 300267007561 domain linker motif; other site 300267007562 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 300267007563 dimerization interface (closed form) [polypeptide binding]; other site 300267007564 ligand binding site [chemical binding]; other site 300267007565 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 300267007566 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 300267007567 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 300267007568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267007569 non-specific DNA binding site [nucleotide binding]; other site 300267007570 salt bridge; other site 300267007571 sequence-specific DNA binding site [nucleotide binding]; other site 300267007572 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 300267007573 nickel binding site [ion binding]; other site 300267007574 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 300267007575 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 300267007576 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267007577 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 300267007578 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 300267007579 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 300267007580 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 300267007581 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267007582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267007583 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 300267007584 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 300267007585 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 300267007586 hydrogenase assembly chaperone; Provisional; Region: PRK10409 300267007587 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 300267007588 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 300267007589 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 300267007590 dimerization interface [polypeptide binding]; other site 300267007591 ATP binding site [chemical binding]; other site 300267007592 HTH-like domain; Region: HTH_21; pfam13276 300267007593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267007594 Integrase core domain; Region: rve; pfam00665 300267007595 Integrase core domain; Region: rve_3; pfam13683 300267007596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007597 Transposase; Region: HTH_Tnp_1; pfam01527 300267007598 TOBE domain; Region: TOBE; cl01440 300267007599 TOBE domain; Region: TOBE; cl01440 300267007600 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 300267007601 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 300267007602 MutS domain I; Region: MutS_I; pfam01624 300267007603 MutS domain II; Region: MutS_II; pfam05188 300267007604 MutS domain III; Region: MutS_III; pfam05192 300267007605 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 300267007606 Walker A/P-loop; other site 300267007607 ATP binding site [chemical binding]; other site 300267007608 Q-loop/lid; other site 300267007609 ABC transporter signature motif; other site 300267007610 Walker B; other site 300267007611 D-loop; other site 300267007612 H-loop/switch region; other site 300267007613 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007615 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007616 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007617 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 300267007618 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 300267007619 Transcriptional regulators [Transcription]; Region: MarR; COG1846 300267007620 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 300267007621 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 300267007622 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 300267007623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 300267007624 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 300267007625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 300267007626 DNA binding residues [nucleotide binding] 300267007627 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 300267007628 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 300267007629 Peptidase family M23; Region: Peptidase_M23; pfam01551 300267007630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267007631 S-adenosylmethionine binding site [chemical binding]; other site 300267007632 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 300267007633 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 300267007634 Permutation of conserved domain; other site 300267007635 active site 300267007636 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 300267007637 homotrimer interaction site [polypeptide binding]; other site 300267007638 zinc binding site [ion binding]; other site 300267007639 CDP-binding sites; other site 300267007640 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 300267007641 substrate binding site; other site 300267007642 dimer interface; other site 300267007643 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 300267007644 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 300267007645 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 300267007646 ligand-binding site [chemical binding]; other site 300267007647 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 300267007648 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 300267007649 CysD dimerization site [polypeptide binding]; other site 300267007650 G1 box; other site 300267007651 putative GEF interaction site [polypeptide binding]; other site 300267007652 GTP/Mg2+ binding site [chemical binding]; other site 300267007653 Switch I region; other site 300267007654 G2 box; other site 300267007655 G3 box; other site 300267007656 Switch II region; other site 300267007657 G4 box; other site 300267007658 G5 box; other site 300267007659 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 300267007660 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 300267007661 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 300267007662 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 300267007663 Active Sites [active] 300267007664 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 300267007665 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 300267007666 metal binding site [ion binding]; metal-binding site 300267007667 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 300267007668 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 300267007669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007670 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007671 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007672 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007674 Transposase; Region: HTH_Tnp_1; pfam01527 300267007675 HTH-like domain; Region: HTH_21; pfam13276 300267007676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267007677 Integrase core domain; Region: rve; pfam00665 300267007678 Integrase core domain; Region: rve_3; pfam13683 300267007679 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007681 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007682 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007683 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 300267007684 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 300267007685 Active Sites [active] 300267007686 sulfite reductase subunit beta; Provisional; Region: PRK13504 300267007687 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 300267007688 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 300267007689 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 300267007690 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267007691 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 300267007692 Flavodoxin; Region: Flavodoxin_1; pfam00258 300267007693 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 300267007694 FAD binding pocket [chemical binding]; other site 300267007695 FAD binding motif [chemical binding]; other site 300267007696 catalytic residues [active] 300267007697 NAD binding pocket [chemical binding]; other site 300267007698 phosphate binding motif [ion binding]; other site 300267007699 beta-alpha-beta structure motif; other site 300267007700 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 300267007701 active site 300267007702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267007703 putative oxidoreductase FixC; Provisional; Region: PRK10157 300267007704 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 300267007705 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 300267007706 benzoate transport; Region: 2A0115; TIGR00895 300267007707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267007708 putative substrate translocation pore; other site 300267007709 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007711 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007712 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007713 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 300267007714 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 300267007715 NADP binding site [chemical binding]; other site 300267007716 homodimer interface [polypeptide binding]; other site 300267007717 active site 300267007718 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 300267007719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 300267007720 nucleotide binding site [chemical binding]; other site 300267007721 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267007722 HTH-like domain; Region: HTH_21; pfam13276 300267007723 Integrase core domain; Region: rve; pfam00665 300267007724 Integrase core domain; Region: rve_3; pfam13683 300267007725 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267007726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007727 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 300267007728 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 300267007729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007730 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007731 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007732 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007733 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007735 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007736 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007738 Transposase; Region: HTH_Tnp_1; pfam01527 300267007739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267007740 Transposase; Region: HTH_Tnp_1; pfam01527 300267007741 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 300267007742 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007744 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007745 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007746 enolase; Provisional; Region: eno; PRK00077 300267007747 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 300267007748 dimer interface [polypeptide binding]; other site 300267007749 metal binding site [ion binding]; metal-binding site 300267007750 substrate binding pocket [chemical binding]; other site 300267007751 CTP synthetase; Validated; Region: pyrG; PRK05380 300267007752 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 300267007753 Catalytic site [active] 300267007754 active site 300267007755 UTP binding site [chemical binding]; other site 300267007756 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 300267007757 active site 300267007758 putative oxyanion hole; other site 300267007759 catalytic triad [active] 300267007760 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 300267007761 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 300267007762 homodimer interface [polypeptide binding]; other site 300267007763 metal binding site [ion binding]; metal-binding site 300267007764 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 300267007765 homodimer interface [polypeptide binding]; other site 300267007766 active site 300267007767 putative chemical substrate binding site [chemical binding]; other site 300267007768 metal binding site [ion binding]; metal-binding site 300267007769 toxin MazF; Provisional; Region: PRK09907 300267007770 antitoxin MazE; Provisional; Region: PRK09798 300267007771 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 300267007772 HD domain; Region: HD_4; pfam13328 300267007773 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 300267007774 synthetase active site [active] 300267007775 NTP binding site [chemical binding]; other site 300267007776 metal binding site [ion binding]; metal-binding site 300267007777 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 300267007778 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 300267007779 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 300267007780 TRAM domain; Region: TRAM; pfam01938 300267007781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267007782 S-adenosylmethionine binding site [chemical binding]; other site 300267007783 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 300267007784 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 300267007785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267007786 dimerization interface [polypeptide binding]; other site 300267007787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267007788 dimer interface [polypeptide binding]; other site 300267007789 phosphorylation site [posttranslational modification] 300267007790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267007791 ATP binding site [chemical binding]; other site 300267007792 Mg2+ binding site [ion binding]; other site 300267007793 G-X-G motif; other site 300267007794 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 300267007795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267007796 active site 300267007797 phosphorylation site [posttranslational modification] 300267007798 intermolecular recognition site; other site 300267007799 dimerization interface [polypeptide binding]; other site 300267007800 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 300267007801 putative binding surface; other site 300267007802 active site 300267007803 flavodoxin; Provisional; Region: PRK08105 300267007804 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 300267007805 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 300267007806 probable active site [active] 300267007807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 300267007808 SecY interacting protein Syd; Provisional; Region: PRK04968 300267007809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 300267007810 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 300267007811 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 300267007812 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 300267007813 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 300267007814 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 300267007815 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 300267007816 serine transporter; Region: stp; TIGR00814 300267007817 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 300267007818 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 300267007819 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 300267007820 flap endonuclease-like protein; Provisional; Region: PRK09482 300267007821 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 300267007822 active site 300267007823 metal binding site 1 [ion binding]; metal-binding site 300267007824 putative 5' ssDNA interaction site; other site 300267007825 metal binding site 3; metal-binding site 300267007826 metal binding site 2 [ion binding]; metal-binding site 300267007827 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 300267007828 putative DNA binding site [nucleotide binding]; other site 300267007829 putative metal binding site [ion binding]; other site 300267007830 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 300267007831 dimer interface [polypeptide binding]; other site 300267007832 active site 300267007833 metal binding site [ion binding]; metal-binding site 300267007834 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 300267007835 intersubunit interface [polypeptide binding]; other site 300267007836 active site 300267007837 Zn2+ binding site [ion binding]; other site 300267007838 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267007839 L-fucose isomerase; Provisional; Region: fucI; PRK10991 300267007840 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 300267007841 hexamer (dimer of trimers) interface [polypeptide binding]; other site 300267007842 trimer interface [polypeptide binding]; other site 300267007843 substrate binding site [chemical binding]; other site 300267007844 Mn binding site [ion binding]; other site 300267007845 L-fuculokinase; Provisional; Region: PRK10331 300267007846 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 300267007847 nucleotide binding site [chemical binding]; other site 300267007848 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 300267007849 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 300267007850 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 300267007851 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267007852 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 300267007853 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 300267007854 hypothetical protein; Provisional; Region: PRK10873 300267007855 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 300267007856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267007857 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 300267007858 dimerization interface [polypeptide binding]; other site 300267007859 substrate binding pocket [chemical binding]; other site 300267007860 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 300267007861 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 300267007862 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 300267007863 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 300267007864 catalytic residue [active] 300267007865 CsdA-binding activator; Provisional; Region: PRK15019 300267007866 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 300267007867 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 300267007868 putative ATP binding site [chemical binding]; other site 300267007869 putative substrate interface [chemical binding]; other site 300267007870 murein transglycosylase A; Provisional; Region: mltA; PRK11162 300267007871 MltA specific insert domain; Region: MltA; smart00925 300267007872 3D domain; Region: 3D; pfam06725 300267007873 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 300267007874 AMIN domain; Region: AMIN; pfam11741 300267007875 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 300267007876 active site 300267007877 metal binding site [ion binding]; metal-binding site 300267007878 N-acetylglutamate synthase; Validated; Region: PRK05279 300267007879 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 300267007880 putative feedback inhibition sensing region; other site 300267007881 putative nucleotide binding site [chemical binding]; other site 300267007882 putative substrate binding site [chemical binding]; other site 300267007883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267007884 Coenzyme A binding pocket [chemical binding]; other site 300267007885 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 300267007886 AAA domain; Region: AAA_30; pfam13604 300267007887 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 300267007888 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 300267007889 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 300267007890 protease3; Provisional; Region: PRK15101 300267007891 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 300267007892 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 300267007893 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 300267007894 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 300267007895 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 300267007896 hypothetical protein; Provisional; Region: PRK10332 300267007897 hypothetical protein; Provisional; Region: PRK11521 300267007898 hypothetical protein; Provisional; Region: PRK10557 300267007899 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 300267007900 hypothetical protein; Provisional; Region: PRK10506 300267007901 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 300267007902 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 300267007903 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 300267007904 dimerization interface [polypeptide binding]; other site 300267007905 active site 300267007906 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 300267007907 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 300267007908 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 300267007909 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 300267007910 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 300267007911 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 300267007912 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 300267007913 putative active site [active] 300267007914 Ap4A binding site [chemical binding]; other site 300267007915 nudix motif; other site 300267007916 putative metal binding site [ion binding]; other site 300267007917 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 300267007918 putative DNA-binding cleft [nucleotide binding]; other site 300267007919 putative DNA clevage site; other site 300267007920 molecular lever; other site 300267007921 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 300267007922 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 300267007923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 300267007924 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 300267007925 active site 300267007926 catalytic tetrad [active] 300267007927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267007928 putative substrate translocation pore; other site 300267007929 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 300267007930 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 300267007931 putative acyl-acceptor binding pocket; other site 300267007932 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 300267007933 acyl-activating enzyme (AAE) consensus motif; other site 300267007934 putative AMP binding site [chemical binding]; other site 300267007935 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 300267007936 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267007937 DNA binding site [nucleotide binding] 300267007938 domain linker motif; other site 300267007939 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 300267007940 dimerization interface (closed form) [polypeptide binding]; other site 300267007941 ligand binding site [chemical binding]; other site 300267007942 diaminopimelate decarboxylase; Provisional; Region: PRK11165 300267007943 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 300267007944 active site 300267007945 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 300267007946 substrate binding site [chemical binding]; other site 300267007947 catalytic residues [active] 300267007948 dimer interface [polypeptide binding]; other site 300267007949 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 300267007950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267007951 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 300267007952 putative dimerization interface [polypeptide binding]; other site 300267007953 putative racemase; Provisional; Region: PRK10200 300267007954 D-galactonate transporter; Region: 2A0114; TIGR00893 300267007955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267007956 putative substrate translocation pore; other site 300267007957 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007959 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007960 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 300267007962 active site 300267007963 catalytic tetrad [active] 300267007964 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 300267007965 dimer interface [polypeptide binding]; other site 300267007966 active site 300267007967 metal binding site [ion binding]; metal-binding site 300267007968 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 300267007969 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 300267007970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267007971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267007972 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 300267007973 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 300267007974 homodimer interface [polypeptide binding]; other site 300267007975 substrate-cofactor binding pocket; other site 300267007976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267007977 catalytic residue [active] 300267007978 biopolymer transport protein ExbB; Provisional; Region: PRK10414 300267007979 biopolymer transport protein ExbD; Provisional; Region: PRK11267 300267007980 oxidoreductase; Provisional; Region: PRK07985 300267007981 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 300267007982 NAD binding site [chemical binding]; other site 300267007983 metal binding site [ion binding]; metal-binding site 300267007984 active site 300267007985 hypothetical protein; Provisional; Region: PRK05208 300267007986 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267007987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267007988 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267007989 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267007990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 300267007991 active site 300267007992 catalytic tetrad [active] 300267007993 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 300267007994 hydrogenase 2 small subunit; Provisional; Region: PRK10468 300267007995 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 300267007996 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 300267007997 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 300267007998 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 300267007999 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 300267008000 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 300267008001 hydrogenase 2 large subunit; Provisional; Region: PRK10467 300267008002 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 300267008003 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 300267008004 putative substrate-binding site; other site 300267008005 nickel binding site [ion binding]; other site 300267008006 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 300267008007 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 300267008008 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 300267008009 putative S-transferase; Provisional; Region: PRK11752 300267008010 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 300267008011 C-terminal domain interface [polypeptide binding]; other site 300267008012 GSH binding site (G-site) [chemical binding]; other site 300267008013 dimer interface [polypeptide binding]; other site 300267008014 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 300267008015 dimer interface [polypeptide binding]; other site 300267008016 N-terminal domain interface [polypeptide binding]; other site 300267008017 active site 300267008018 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 300267008019 CHAP domain; Region: CHAP; pfam05257 300267008020 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 300267008021 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 300267008022 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 300267008023 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 300267008024 TMP-binding site; other site 300267008025 ATP-binding site [chemical binding]; other site 300267008026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008027 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008028 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008029 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 300267008030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 300267008031 NAD(P) binding site [chemical binding]; other site 300267008032 active site 300267008033 acyl-CoA synthetase; Validated; Region: PRK09192 300267008034 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 300267008035 acyl-activating enzyme (AAE) consensus motif; other site 300267008036 active site 300267008037 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008039 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008040 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008041 putative type II secretion protein GspC; Provisional; Region: PRK09681 300267008042 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 300267008043 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 300267008044 type II secretion system protein D; Region: type_II_gspD; TIGR02517 300267008045 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 300267008046 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 300267008047 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 300267008048 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 300267008049 type II secretion system protein E; Region: type_II_gspE; TIGR02533 300267008050 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 300267008051 Walker A motif; other site 300267008052 ATP binding site [chemical binding]; other site 300267008053 Walker B motif; other site 300267008054 type II secretion system protein F; Region: GspF; TIGR02120 300267008055 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 300267008056 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 300267008057 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 300267008058 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 300267008059 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 300267008060 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 300267008061 type II secretion system protein I; Region: gspI; TIGR01707 300267008062 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 300267008063 type II secretion system protein J; Region: gspJ; TIGR01711 300267008064 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 300267008065 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 300267008066 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 300267008067 GspL-like protein; Provisional; Region: PRK09662 300267008068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008069 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008070 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008071 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008072 ornithine decarboxylase; Provisional; Region: PRK13578 300267008073 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 300267008074 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 300267008075 homodimer interface [polypeptide binding]; other site 300267008076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267008077 catalytic residue [active] 300267008078 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 300267008079 nucleoside transporter; Region: 2A0110; TIGR00889 300267008080 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 300267008081 murein transglycosylase C; Provisional; Region: mltC; PRK11671 300267008082 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 300267008083 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 300267008084 N-acetyl-D-glucosamine binding site [chemical binding]; other site 300267008085 catalytic residue [active] 300267008086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 300267008087 adenine DNA glycosylase; Provisional; Region: PRK10880 300267008088 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 300267008089 minor groove reading motif; other site 300267008090 helix-hairpin-helix signature motif; other site 300267008091 substrate binding pocket [chemical binding]; other site 300267008092 active site 300267008093 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 300267008094 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 300267008095 DNA binding and oxoG recognition site [nucleotide binding] 300267008096 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 300267008097 hypothetical protein; Provisional; Region: PRK11702 300267008098 hypothetical protein; Provisional; Region: PRK10626 300267008099 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 300267008100 active site 300267008101 homodimer interface [polypeptide binding]; other site 300267008102 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 300267008103 HemN family oxidoreductase; Provisional; Region: PRK05660 300267008104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267008105 FeS/SAM binding site; other site 300267008106 HemN C-terminal domain; Region: HemN_C; pfam06969 300267008107 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 300267008108 active site 300267008109 dimerization interface [polypeptide binding]; other site 300267008110 hypothetical protein; Validated; Region: PRK05090 300267008111 YGGT family; Region: YGGT; pfam02325 300267008112 Predicted integral membrane protein [Function unknown]; Region: COG0762 300267008113 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 300267008114 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 300267008115 catalytic residue [active] 300267008116 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 300267008117 Walker A motif; other site 300267008118 ATP binding site [chemical binding]; other site 300267008119 Walker B motif; other site 300267008120 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 300267008121 hypothetical protein; Validated; Region: PRK00228 300267008122 glutathione synthetase; Provisional; Region: PRK05246 300267008123 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 300267008124 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 300267008125 RNA methyltransferase, RsmE family; Region: TIGR00046 300267008126 DNA-specific endonuclease I; Provisional; Region: PRK15137 300267008127 hypothetical protein; Provisional; Region: PRK04860 300267008128 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 300267008129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267008130 putative substrate translocation pore; other site 300267008131 S-adenosylmethionine synthetase; Validated; Region: PRK05250 300267008132 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 300267008133 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 300267008134 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 300267008135 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 300267008136 Virulence promoting factor; Region: YqgB; pfam11036 300267008137 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 300267008138 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 300267008139 dimer interface [polypeptide binding]; other site 300267008140 active site 300267008141 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 300267008142 catalytic residues [active] 300267008143 substrate binding site [chemical binding]; other site 300267008144 NlpB/DapX lipoprotein; Region: Lipoprotein_18; cl19507 300267008145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008146 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008147 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008148 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008149 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 300267008150 oligomer interface [polypeptide binding]; other site 300267008151 putative active site [active] 300267008152 Mn binding site [ion binding]; other site 300267008153 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 300267008154 transketolase; Reviewed; Region: PRK12753 300267008155 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 300267008156 TPP-binding site [chemical binding]; other site 300267008157 dimer interface [polypeptide binding]; other site 300267008158 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 300267008159 PYR/PP interface [polypeptide binding]; other site 300267008160 dimer interface [polypeptide binding]; other site 300267008161 TPP binding site [chemical binding]; other site 300267008162 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 300267008163 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008165 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008166 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008167 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 300267008168 active site 300267008169 phosphorylation site [posttranslational modification] 300267008170 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 300267008171 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 300267008172 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 300267008173 active site 300267008174 P-loop; other site 300267008175 phosphorylation site [posttranslational modification] 300267008176 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 300267008177 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 300267008178 putative NAD(P) binding site [chemical binding]; other site 300267008179 catalytic Zn binding site [ion binding]; other site 300267008180 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 300267008181 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 300267008182 active site 300267008183 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 300267008184 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 300267008185 Walker A/P-loop; other site 300267008186 ATP binding site [chemical binding]; other site 300267008187 Q-loop/lid; other site 300267008188 ABC transporter signature motif; other site 300267008189 Walker B; other site 300267008190 D-loop; other site 300267008191 H-loop/switch region; other site 300267008192 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 300267008193 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 300267008194 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 300267008195 trimer interface [polypeptide binding]; other site 300267008196 putative Zn binding site [ion binding]; other site 300267008197 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 300267008198 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 300267008199 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 300267008200 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 300267008201 substrate binding site [chemical binding]; other site 300267008202 hinge regions; other site 300267008203 ADP binding site [chemical binding]; other site 300267008204 catalytic site [active] 300267008205 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 300267008206 active site 300267008207 intersubunit interface [polypeptide binding]; other site 300267008208 zinc binding site [ion binding]; other site 300267008209 Na+ binding site [ion binding]; other site 300267008210 mechanosensitive channel MscS; Provisional; Region: PRK10334 300267008211 Conserved TM helix; Region: TM_helix; pfam05552 300267008212 Mechanosensitive ion channel; Region: MS_channel; pfam00924 300267008213 arginine exporter protein; Provisional; Region: PRK09304 300267008214 oxidative stress defense protein; Provisional; Region: PRK11087 300267008215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008216 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008217 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008218 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008219 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 300267008220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267008221 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 300267008222 putative dimerization interface [polypeptide binding]; other site 300267008223 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008225 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008226 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008227 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 300267008228 tetramer (dimer of dimers) interface [polypeptide binding]; other site 300267008229 active site 300267008230 dimer interface [polypeptide binding]; other site 300267008231 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 300267008232 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 300267008233 ligand binding site [chemical binding]; other site 300267008234 NAD binding site [chemical binding]; other site 300267008235 tetramer interface [polypeptide binding]; other site 300267008236 catalytic site [active] 300267008237 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 300267008238 L-serine binding site [chemical binding]; other site 300267008239 ACT domain interface; other site 300267008240 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 300267008241 Z-ring-associated protein; Provisional; Region: PRK10972 300267008242 hypothetical protein; Reviewed; Region: PRK01736 300267008243 proline aminopeptidase P II; Provisional; Region: PRK10879 300267008244 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 300267008245 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 300267008246 active site 300267008247 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 300267008248 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 300267008249 oxidoreductase; Provisional; Region: PRK08013 300267008250 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 300267008251 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 300267008252 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 300267008253 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 300267008254 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 300267008255 lipoyl attachment site [posttranslational modification]; other site 300267008256 glycine dehydrogenase; Provisional; Region: PRK05367 300267008257 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 300267008258 tetramer interface [polypeptide binding]; other site 300267008259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267008260 catalytic residue [active] 300267008261 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 300267008262 tetramer interface [polypeptide binding]; other site 300267008263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267008264 catalytic residue [active] 300267008265 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 300267008266 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008268 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008269 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008270 hemolysin; Provisional; Region: PRK15087 300267008271 putative global regulator; Reviewed; Region: PRK09559 300267008272 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 300267008273 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 300267008274 hypothetical protein; Provisional; Region: PRK10878 300267008275 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 300267008276 flavodoxin FldB; Provisional; Region: PRK12359 300267008277 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 300267008278 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 300267008279 active site 300267008280 Int/Topo IB signature motif; other site 300267008281 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 300267008282 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 300267008283 dimerization domain [polypeptide binding]; other site 300267008284 dimer interface [polypeptide binding]; other site 300267008285 catalytic residues [active] 300267008286 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 300267008287 DHH family; Region: DHH; pfam01368 300267008288 DHHA1 domain; Region: DHHA1; pfam02272 300267008289 peptide chain release factor 2; Provisional; Region: PRK08787 300267008290 This domain is found in peptide chain release factors; Region: PCRF; smart00937 300267008291 RF-1 domain; Region: RF-1; pfam00472 300267008292 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 300267008293 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 300267008294 dimer interface [polypeptide binding]; other site 300267008295 putative anticodon binding site; other site 300267008296 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 300267008297 motif 1; other site 300267008298 active site 300267008299 motif 2; other site 300267008300 motif 3; other site 300267008301 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 300267008302 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 300267008303 active site 300267008304 metal binding site [ion binding]; metal-binding site 300267008305 nudix motif; other site 300267008306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008307 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008308 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267008310 Transposase; Region: HTH_Tnp_1; pfam01527 300267008311 HTH-like domain; Region: HTH_21; pfam13276 300267008312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267008313 Integrase core domain; Region: rve; pfam00665 300267008314 Integrase core domain; Region: rve_3; pfam13683 300267008315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008316 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008317 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008318 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008319 zinc transporter ZupT; Provisional; Region: PRK04201 300267008320 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 300267008321 hypothetical protein; Provisional; Region: PRK11653 300267008322 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 300267008323 Outer membrane efflux protein; Region: OEP; pfam02321 300267008324 Outer membrane efflux protein; Region: OEP; pfam02321 300267008325 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 300267008326 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 300267008327 dimer interface [polypeptide binding]; other site 300267008328 ADP-ribose binding site [chemical binding]; other site 300267008329 active site 300267008330 nudix motif; other site 300267008331 metal binding site [ion binding]; metal-binding site 300267008332 putative dehydrogenase; Provisional; Region: PRK11039 300267008333 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 300267008334 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 300267008335 active site 300267008336 metal binding site [ion binding]; metal-binding site 300267008337 hexamer interface [polypeptide binding]; other site 300267008338 esterase YqiA; Provisional; Region: PRK11071 300267008339 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 300267008340 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 300267008341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267008342 ATP binding site [chemical binding]; other site 300267008343 Mg2+ binding site [ion binding]; other site 300267008344 G-X-G motif; other site 300267008345 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 300267008346 anchoring element; other site 300267008347 dimer interface [polypeptide binding]; other site 300267008348 ATP binding site [chemical binding]; other site 300267008349 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 300267008350 active site 300267008351 metal binding site [ion binding]; metal-binding site 300267008352 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 300267008353 Uncharacterized conserved protein [Function unknown]; Region: COG1359 300267008354 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 300267008355 sensor protein QseC; Provisional; Region: PRK10337 300267008356 HAMP domain; Region: HAMP; pfam00672 300267008357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267008358 dimer interface [polypeptide binding]; other site 300267008359 phosphorylation site [posttranslational modification] 300267008360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267008361 ATP binding site [chemical binding]; other site 300267008362 Mg2+ binding site [ion binding]; other site 300267008363 G-X-G motif; other site 300267008364 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 300267008365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267008366 active site 300267008367 phosphorylation site [posttranslational modification] 300267008368 intermolecular recognition site; other site 300267008369 dimerization interface [polypeptide binding]; other site 300267008370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267008371 DNA binding site [nucleotide binding] 300267008372 TIGR00156 family protein; Region: TIGR00156 300267008373 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 300267008374 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 300267008375 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 300267008376 peptide binding site [polypeptide binding]; other site 300267008377 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 300267008378 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 300267008379 CAP-like domain; other site 300267008380 active site 300267008381 primary dimer interface [polypeptide binding]; other site 300267008382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 300267008383 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 300267008384 putative acyl-acceptor binding pocket; other site 300267008385 FtsI repressor; Provisional; Region: PRK10883 300267008386 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 300267008387 Domain 2 interface [polypeptide binding]; other site 300267008388 Domain 3 interface [polypeptide binding]; other site 300267008389 trinuclear Cu binding site [ion binding]; other site 300267008390 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 300267008391 Domain 1 interface [polypeptide binding]; other site 300267008392 Domain 3 interface [polypeptide binding]; other site 300267008393 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 300267008394 Domain 2 interface [polypeptide binding]; other site 300267008395 Domain 1 interface [polypeptide binding]; other site 300267008396 Type 1 (T1) Cu binding site [ion binding]; other site 300267008397 trinuclear Cu binding site [ion binding]; other site 300267008398 putative outer membrane lipoprotein; Provisional; Region: PRK09973 300267008399 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008401 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008402 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008403 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 300267008404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 300267008405 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 300267008406 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008408 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008409 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008410 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008412 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008413 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008415 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008416 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008417 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008418 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 300267008419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 300267008420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 300267008421 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 300267008422 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 300267008423 putative ribose interaction site [chemical binding]; other site 300267008424 putative ADP binding site [chemical binding]; other site 300267008425 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 300267008426 active site 300267008427 nucleotide binding site [chemical binding]; other site 300267008428 HIGH motif; other site 300267008429 KMSKS motif; other site 300267008430 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 300267008431 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 300267008432 metal binding triad; other site 300267008433 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 300267008434 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 300267008435 metal binding triad; other site 300267008436 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 300267008437 Uncharacterized conserved protein [Function unknown]; Region: COG3025 300267008438 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 300267008439 putative active site [active] 300267008440 putative metal binding residues [ion binding]; other site 300267008441 signature motif; other site 300267008442 putative triphosphate binding site [ion binding]; other site 300267008443 CHAD domain; Region: CHAD; pfam05235 300267008444 SH3 domain-containing protein; Provisional; Region: PRK10884 300267008445 Bacterial SH3 domain homologues; Region: SH3b; smart00287 300267008446 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 300267008447 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 300267008448 active site 300267008449 NTP binding site [chemical binding]; other site 300267008450 metal binding triad [ion binding]; metal-binding site 300267008451 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 300267008452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 300267008453 Zn2+ binding site [ion binding]; other site 300267008454 Mg2+ binding site [ion binding]; other site 300267008455 original product: bacitracin resistance protein BacA 300267008456 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 300267008457 homooctamer interface [polypeptide binding]; other site 300267008458 active site 300267008459 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 300267008460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008461 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008462 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008463 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008464 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 300267008465 anion transporter; Region: dass; TIGR00785 300267008466 transmembrane helices; other site 300267008467 UGMP family protein; Validated; Region: PRK09604 300267008468 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267008469 nucleotide binding site [chemical binding]; other site 300267008470 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 300267008471 DNA primase; Validated; Region: dnaG; PRK05667 300267008472 CHC2 zinc finger; Region: zf-CHC2; pfam01807 300267008473 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 300267008474 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 300267008475 active site 300267008476 metal binding site [ion binding]; metal-binding site 300267008477 interdomain interaction site; other site 300267008478 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 300267008479 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 300267008480 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 300267008481 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 300267008482 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 300267008483 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 300267008484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 300267008485 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 300267008486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 300267008487 DNA binding residues [nucleotide binding] 300267008488 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 300267008489 active site 300267008490 SUMO-1 interface [polypeptide binding]; other site 300267008491 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 300267008492 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 300267008493 FAD binding pocket [chemical binding]; other site 300267008494 FAD binding motif [chemical binding]; other site 300267008495 phosphate binding motif [ion binding]; other site 300267008496 NAD binding pocket [chemical binding]; other site 300267008497 Predicted transcriptional regulators [Transcription]; Region: COG1695 300267008498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 300267008499 PAS fold; Region: PAS_3; pfam08447 300267008500 putative active site [active] 300267008501 heme pocket [chemical binding]; other site 300267008502 Protein of unknown function (DUF418); Region: DUF418; cl12135 300267008503 HAMP domain; Region: HAMP; pfam00672 300267008504 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 300267008505 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 300267008506 dimer interface [polypeptide binding]; other site 300267008507 putative CheW interface [polypeptide binding]; other site 300267008508 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 300267008509 dimer interface [polypeptide binding]; other site 300267008510 putative tRNA-binding site [nucleotide binding]; other site 300267008511 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 300267008512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267008513 DNA binding site [nucleotide binding] 300267008514 domain linker motif; other site 300267008515 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 300267008516 putative dimerization interface [polypeptide binding]; other site 300267008517 putative ligand binding site [chemical binding]; other site 300267008518 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008520 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008521 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008522 alpha-glucosidase; Provisional; Region: PRK10137 300267008523 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 300267008524 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 300267008525 active site 300267008526 FMN binding site [chemical binding]; other site 300267008527 2,4-decadienoyl-CoA binding site; other site 300267008528 catalytic residue [active] 300267008529 4Fe-4S cluster binding site [ion binding]; other site 300267008530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267008531 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 300267008532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267008533 non-specific DNA binding site [nucleotide binding]; other site 300267008534 salt bridge; other site 300267008535 sequence-specific DNA binding site [nucleotide binding]; other site 300267008536 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 300267008537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267008538 S-adenosylmethionine binding site [chemical binding]; other site 300267008539 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 300267008540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008541 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008542 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008543 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008544 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 300267008545 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 300267008546 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 300267008547 serine/threonine transporter SstT; Provisional; Region: PRK13628 300267008548 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 300267008549 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 300267008550 galactarate dehydratase; Region: galactar-dH20; TIGR03248 300267008551 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 300267008552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267008553 D-galactonate transporter; Region: 2A0114; TIGR00893 300267008554 putative substrate translocation pore; other site 300267008555 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008557 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008558 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008559 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 300267008560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267008561 DNA-binding site [nucleotide binding]; DNA binding site 300267008562 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 300267008563 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 300267008564 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 300267008565 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 300267008566 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 300267008567 Predicted membrane protein [Function unknown]; Region: COG5393 300267008568 YqjK-like protein; Region: YqjK; pfam13997 300267008569 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267008570 HTH-like domain; Region: HTH_21; pfam13276 300267008571 Integrase core domain; Region: rve; pfam00665 300267008572 Integrase core domain; Region: rve_3; pfam13683 300267008573 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267008574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267008575 Predicted membrane protein [Function unknown]; Region: COG2259 300267008576 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 300267008577 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 300267008578 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 300267008579 putative dimer interface [polypeptide binding]; other site 300267008580 N-terminal domain interface [polypeptide binding]; other site 300267008581 putative substrate binding pocket (H-site) [chemical binding]; other site 300267008582 Predicted membrane protein [Function unknown]; Region: COG3152 300267008583 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008585 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008586 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008588 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008589 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008590 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267008592 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 300267008593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 300267008594 dimerization interface [polypeptide binding]; other site 300267008595 Pirin-related protein [General function prediction only]; Region: COG1741 300267008596 Pirin; Region: Pirin; pfam02678 300267008597 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 300267008598 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 300267008599 serine transporter; Region: stp; TIGR00814 300267008600 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008602 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008603 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008604 L-serine dehydratase TdcG; Provisional; Region: PRK15040 300267008605 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 300267008606 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 300267008607 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 300267008608 Pyruvate formate lyase 1; Region: PFL1; cd01678 300267008609 coenzyme A binding site [chemical binding]; other site 300267008610 active site 300267008611 catalytic residues [active] 300267008612 glycine loop; other site 300267008613 propionate/acetate kinase; Provisional; Region: PRK12379 300267008614 threonine/serine transporter TdcC; Provisional; Region: PRK13629 300267008615 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 300267008616 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 300267008617 tetramer interface [polypeptide binding]; other site 300267008618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267008619 catalytic residue [active] 300267008620 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 300267008621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267008622 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 300267008623 putative substrate binding pocket [chemical binding]; other site 300267008624 putative dimerization interface [polypeptide binding]; other site 300267008625 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 300267008626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008627 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008628 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008629 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008631 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008632 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008633 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267008634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008635 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008636 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008637 glycerate kinase I; Provisional; Region: PRK10342 300267008638 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 300267008639 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 300267008640 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 300267008641 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 300267008642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008643 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008644 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008645 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267008646 Fimbrial protein; Region: Fimbrial; cl01416 300267008647 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 300267008648 putative SAM binding site [chemical binding]; other site 300267008649 putative homodimer interface [polypeptide binding]; other site 300267008650 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 300267008651 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 300267008652 putative ligand binding site [chemical binding]; other site 300267008653 TIGR00252 family protein; Region: TIGR00252 300267008654 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 300267008655 dimer interface [polypeptide binding]; other site 300267008656 active site 300267008657 outer membrane lipoprotein; Provisional; Region: PRK11023 300267008658 BON domain; Region: BON; pfam04972 300267008659 BON domain; Region: BON; pfam04972 300267008660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 300267008661 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 300267008662 NAD(P) binding site [chemical binding]; other site 300267008663 active site 300267008664 intracellular protease, PfpI family; Region: PfpI; TIGR01382 300267008665 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 300267008666 proposed catalytic triad [active] 300267008667 conserved cys residue [active] 300267008668 hypothetical protein; Provisional; Region: PRK03467 300267008669 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 300267008670 GIY-YIG motif/motif A; other site 300267008671 putative active site [active] 300267008672 putative metal binding site [ion binding]; other site 300267008673 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 300267008674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267008675 Coenzyme A binding pocket [chemical binding]; other site 300267008676 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 300267008677 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 300267008678 putative protease; Provisional; Region: PRK15447 300267008679 hypothetical protein; Provisional; Region: PRK10508 300267008680 tryptophan permease; Provisional; Region: PRK10483 300267008681 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 300267008682 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 300267008683 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 300267008684 ATP binding site [chemical binding]; other site 300267008685 Mg++ binding site [ion binding]; other site 300267008686 motif III; other site 300267008687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267008688 nucleotide binding region [chemical binding]; other site 300267008689 ATP-binding site [chemical binding]; other site 300267008690 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 300267008691 putative RNA binding site [nucleotide binding]; other site 300267008692 lipoprotein NlpI; Provisional; Region: PRK11189 300267008693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 300267008694 binding surface 300267008695 TPR motif; other site 300267008696 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 300267008697 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 300267008698 RNase E interface [polypeptide binding]; other site 300267008699 trimer interface [polypeptide binding]; other site 300267008700 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 300267008701 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 300267008702 RNase E interface [polypeptide binding]; other site 300267008703 trimer interface [polypeptide binding]; other site 300267008704 active site 300267008705 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 300267008706 putative nucleic acid binding region [nucleotide binding]; other site 300267008707 G-X-X-G motif; other site 300267008708 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 300267008709 RNA binding site [nucleotide binding]; other site 300267008710 domain interface; other site 300267008711 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 300267008712 16S/18S rRNA binding site [nucleotide binding]; other site 300267008713 S13e-L30e interaction site [polypeptide binding]; other site 300267008714 25S rRNA binding site [nucleotide binding]; other site 300267008715 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 300267008716 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 300267008717 RNA binding site [nucleotide binding]; other site 300267008718 active site 300267008719 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 300267008720 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 300267008721 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 300267008722 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 300267008723 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 300267008724 translation initiation factor IF-2; Validated; Region: infB; PRK05306 300267008725 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 300267008726 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 300267008727 G1 box; other site 300267008728 putative GEF interaction site [polypeptide binding]; other site 300267008729 GTP/Mg2+ binding site [chemical binding]; other site 300267008730 Switch I region; other site 300267008731 G2 box; other site 300267008732 G3 box; other site 300267008733 Switch II region; other site 300267008734 G4 box; other site 300267008735 G5 box; other site 300267008736 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 300267008737 Translation-initiation factor 2; Region: IF-2; pfam11987 300267008738 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 300267008739 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 300267008740 NusA N-terminal domain; Region: NusA_N; pfam08529 300267008741 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 300267008742 RNA binding site [nucleotide binding]; other site 300267008743 homodimer interface [polypeptide binding]; other site 300267008744 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 300267008745 G-X-X-G motif; other site 300267008746 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 300267008747 G-X-X-G motif; other site 300267008748 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 300267008749 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 300267008750 hypothetical protein; Provisional; Region: PRK14641 300267008751 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 300267008752 putative oligomer interface [polypeptide binding]; other site 300267008753 putative RNA binding site [nucleotide binding]; other site 300267008754 argininosuccinate synthase; Validated; Region: PRK05370 300267008755 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 300267008756 Sulfatase; Region: Sulfatase; pfam00884 300267008757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267008758 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267008759 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267008760 Preprotein translocase SecG subunit; Region: SecG; pfam03840 300267008761 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 300267008762 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 300267008763 active site 300267008764 substrate binding site [chemical binding]; other site 300267008765 metal binding site [ion binding]; metal-binding site 300267008766 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 300267008767 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 300267008768 substrate binding pocket [chemical binding]; other site 300267008769 dimer interface [polypeptide binding]; other site 300267008770 inhibitor binding site; inhibition site 300267008771 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 300267008772 FtsH Extracellular; Region: FtsH_ext; pfam06480 300267008773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267008774 Walker A motif; other site 300267008775 ATP binding site [chemical binding]; other site 300267008776 Walker B motif; other site 300267008777 arginine finger; other site 300267008778 Peptidase family M41; Region: Peptidase_M41; pfam01434 300267008779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267008780 S-adenosylmethionine binding site [chemical binding]; other site 300267008781 RNA-binding protein YhbY; Provisional; Region: PRK10343 300267008782 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 300267008783 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 300267008784 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 300267008785 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 300267008786 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 300267008787 GTPase CgtA; Reviewed; Region: obgE; PRK12298 300267008788 GTP1/OBG; Region: GTP1_OBG; pfam01018 300267008789 Obg GTPase; Region: Obg; cd01898 300267008790 G1 box; other site 300267008791 GTP/Mg2+ binding site [chemical binding]; other site 300267008792 Switch I region; other site 300267008793 G2 box; other site 300267008794 G3 box; other site 300267008795 Switch II region; other site 300267008796 G4 box; other site 300267008797 G5 box; other site 300267008798 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 300267008799 EamA-like transporter family; Region: EamA; pfam00892 300267008800 EamA-like transporter family; Region: EamA; pfam00892 300267008801 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 300267008802 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 300267008803 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 300267008804 substrate binding pocket [chemical binding]; other site 300267008805 chain length determination region; other site 300267008806 substrate-Mg2+ binding site; other site 300267008807 catalytic residues [active] 300267008808 aspartate-rich region 1; other site 300267008809 active site lid residues [active] 300267008810 aspartate-rich region 2; other site 300267008811 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 300267008812 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 300267008813 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 300267008814 hinge; other site 300267008815 active site 300267008816 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 300267008817 Predicted NTP binding protein (contains STAS domain) [General function prediction only]; Region: COG3113 300267008818 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 300267008819 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 300267008820 mce related protein; Region: MCE; pfam02470 300267008821 conserved hypothetical integral membrane protein; Region: TIGR00056 300267008822 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 300267008823 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 300267008824 Walker A/P-loop; other site 300267008825 ATP binding site [chemical binding]; other site 300267008826 Q-loop/lid; other site 300267008827 ABC transporter signature motif; other site 300267008828 Walker B; other site 300267008829 D-loop; other site 300267008830 H-loop/switch region; other site 300267008831 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 300267008832 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 300267008833 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 300267008834 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 300267008835 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 300267008836 putative active site [active] 300267008837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 300267008838 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 300267008839 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 300267008840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 300267008841 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 300267008842 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 300267008843 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 300267008844 Walker A/P-loop; other site 300267008845 ATP binding site [chemical binding]; other site 300267008846 Q-loop/lid; other site 300267008847 ABC transporter signature motif; other site 300267008848 Walker B; other site 300267008849 D-loop; other site 300267008850 H-loop/switch region; other site 300267008851 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 300267008852 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 300267008853 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 300267008854 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 300267008855 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 300267008856 30S subunit binding site; other site 300267008857 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 300267008858 active site 300267008859 phosphorylation site [posttranslational modification] 300267008860 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 300267008861 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 300267008862 dimerization domain swap beta strand [polypeptide binding]; other site 300267008863 regulatory protein interface [polypeptide binding]; other site 300267008864 active site 300267008865 regulatory phosphorylation site [posttranslational modification]; other site 300267008866 hypothetical protein; Provisional; Region: PRK10345 300267008867 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 300267008868 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 300267008869 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 300267008870 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 300267008871 conserved cys residue [active] 300267008872 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 300267008873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 300267008874 putative active site [active] 300267008875 heme pocket [chemical binding]; other site 300267008876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267008877 dimer interface [polypeptide binding]; other site 300267008878 phosphorylation site [posttranslational modification] 300267008879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267008880 ATP binding site [chemical binding]; other site 300267008881 Mg2+ binding site [ion binding]; other site 300267008882 G-X-G motif; other site 300267008883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267008884 active site 300267008885 phosphorylation site [posttranslational modification] 300267008886 intermolecular recognition site; other site 300267008887 dimerization interface [polypeptide binding]; other site 300267008888 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 300267008889 putative binding surface; other site 300267008890 active site 300267008891 radical SAM protein, TIGR01212 family; Region: TIGR01212 300267008892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267008893 FeS/SAM binding site; other site 300267008894 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 300267008895 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 300267008896 active site 300267008897 dimer interface [polypeptide binding]; other site 300267008898 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 300267008899 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 300267008900 active site 300267008901 FMN binding site [chemical binding]; other site 300267008902 substrate binding site [chemical binding]; other site 300267008903 3Fe-4S cluster binding site [ion binding]; other site 300267008904 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 300267008905 domain interface; other site 300267008906 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 300267008907 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 300267008908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267008909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267008910 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 300267008911 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 300267008912 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 300267008913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 300267008914 nucleotide binding site [chemical binding]; other site 300267008915 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 300267008916 putative active site cavity [active] 300267008917 putative sialic acid transporter; Provisional; Region: PRK03893 300267008918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267008919 putative substrate translocation pore; other site 300267008920 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 300267008921 inhibitor site; inhibition site 300267008922 active site 300267008923 dimer interface [polypeptide binding]; other site 300267008924 catalytic residue [active] 300267008925 transcriptional regulator NanR; Provisional; Region: PRK03837 300267008926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267008927 DNA-binding site [nucleotide binding]; DNA binding site 300267008928 FCD domain; Region: FCD; pfam07729 300267008929 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 300267008930 stringent starvation protein A; Provisional; Region: sspA; PRK09481 300267008931 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 300267008932 C-terminal domain interface [polypeptide binding]; other site 300267008933 putative GSH binding site (G-site) [chemical binding]; other site 300267008934 dimer interface [polypeptide binding]; other site 300267008935 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 300267008936 dimer interface [polypeptide binding]; other site 300267008937 N-terminal domain interface [polypeptide binding]; other site 300267008938 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 300267008939 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 300267008940 23S rRNA interface [nucleotide binding]; other site 300267008941 L3 interface [polypeptide binding]; other site 300267008942 Predicted ATPase [General function prediction only]; Region: COG1485 300267008943 hypothetical protein; Provisional; Region: PRK11677 300267008944 serine endoprotease; Provisional; Region: PRK10139 300267008945 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 300267008946 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 300267008947 protein binding site [polypeptide binding]; other site 300267008948 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 300267008949 serine endoprotease; Provisional; Region: PRK10898 300267008950 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 300267008951 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 300267008952 protein binding site [polypeptide binding]; other site 300267008953 malate dehydrogenase; Provisional; Region: PRK05086 300267008954 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 300267008955 NAD binding site [chemical binding]; other site 300267008956 dimerization interface [polypeptide binding]; other site 300267008957 Substrate binding site [chemical binding]; other site 300267008958 arginine repressor; Provisional; Region: PRK05066 300267008959 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 300267008960 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 300267008961 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 300267008962 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 300267008963 RNAase interaction site [polypeptide binding]; other site 300267008964 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 300267008965 Fusaric acid resistance protein family; Region: FUSC; pfam04632 300267008966 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 300267008967 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 300267008968 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267008969 efflux system membrane protein; Provisional; Region: PRK11594 300267008970 transcriptional regulator; Provisional; Region: PRK10632 300267008971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267008972 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 300267008973 putative effector binding pocket; other site 300267008974 dimerization interface [polypeptide binding]; other site 300267008975 protease TldD; Provisional; Region: tldD; PRK10735 300267008976 hypothetical protein; Provisional; Region: PRK10899 300267008977 Protein of unknown function; Region: DUF3971; pfam13116 300267008978 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 300267008979 ribonuclease G; Provisional; Region: PRK11712 300267008980 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 300267008981 homodimer interface [polypeptide binding]; other site 300267008982 oligonucleotide binding site [chemical binding]; other site 300267008983 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 300267008984 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 300267008985 active site 300267008986 dimer interface [polypeptide binding]; other site 300267008987 rod shape-determining protein MreD; Provisional; Region: PRK11060 300267008988 rod shape-determining protein MreC; Region: mreC; TIGR00219 300267008989 rod shape-determining protein MreB; Provisional; Region: PRK13927 300267008990 MreB and similar proteins; Region: MreB_like; cd10225 300267008991 nucleotide binding site [chemical binding]; other site 300267008992 Mg binding site [ion binding]; other site 300267008993 putative protofilament interaction site [polypeptide binding]; other site 300267008994 RodZ interaction site [polypeptide binding]; other site 300267008995 regulatory protein CsrD; Provisional; Region: PRK11059 300267008996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 300267008997 metal binding site [ion binding]; metal-binding site 300267008998 active site 300267008999 I-site; other site 300267009000 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 300267009001 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 300267009002 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 300267009003 NADP binding site [chemical binding]; other site 300267009004 dimer interface [polypeptide binding]; other site 300267009005 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 300267009006 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 300267009007 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 300267009008 carboxyltransferase (CT) interaction site; other site 300267009009 biotinylation site [posttranslational modification]; other site 300267009010 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 300267009011 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 300267009012 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 300267009013 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 300267009014 hypothetical protein; Provisional; Region: PRK10633 300267009015 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 300267009016 Na binding site [ion binding]; other site 300267009017 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 300267009018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267009019 S-adenosylmethionine binding site [chemical binding]; other site 300267009020 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 300267009021 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 300267009022 FMN binding site [chemical binding]; other site 300267009023 active site 300267009024 catalytic residues [active] 300267009025 substrate binding site [chemical binding]; other site 300267009026 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 300267009027 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009029 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009030 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009032 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009033 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267009035 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 300267009036 substrate binding pocket [chemical binding]; other site 300267009037 membrane-bound complex binding site; other site 300267009038 hinge residues; other site 300267009039 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 300267009040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267009041 dimer interface [polypeptide binding]; other site 300267009042 conserved gate region; other site 300267009043 putative PBP binding loops; other site 300267009044 ABC-ATPase subunit interface; other site 300267009045 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 300267009046 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 300267009047 trimer interface [polypeptide binding]; other site 300267009048 putative metal binding site [ion binding]; other site 300267009049 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 300267009050 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 300267009051 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 300267009052 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 300267009053 shikimate binding site; other site 300267009054 NAD(P) binding site [chemical binding]; other site 300267009055 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 300267009056 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 300267009057 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 300267009058 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 300267009059 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 300267009060 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 300267009061 hypothetical protein; Validated; Region: PRK03430 300267009062 hypothetical protein; Provisional; Region: PRK10736 300267009063 DNA protecting protein DprA; Region: dprA; TIGR00732 300267009064 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 300267009065 active site 300267009066 catalytic residues [active] 300267009067 metal binding site [ion binding]; metal-binding site 300267009068 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 300267009069 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 300267009070 putative active site [active] 300267009071 substrate binding site [chemical binding]; other site 300267009072 putative cosubstrate binding site; other site 300267009073 catalytic site [active] 300267009074 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 300267009075 substrate binding site [chemical binding]; other site 300267009076 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 300267009077 putative RNA binding site [nucleotide binding]; other site 300267009078 16S rRNA methyltransferase B; Provisional; Region: PRK10901 300267009079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267009080 S-adenosylmethionine binding site [chemical binding]; other site 300267009081 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 300267009082 TrkA-N domain; Region: TrkA_N; pfam02254 300267009083 TrkA-C domain; Region: TrkA_C; pfam02080 300267009084 TrkA-N domain; Region: TrkA_N; pfam02254 300267009085 TrkA-C domain; Region: TrkA_C; pfam02080 300267009086 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 300267009087 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 300267009088 DNA binding residues [nucleotide binding] 300267009089 dimer interface [polypeptide binding]; other site 300267009090 metal binding site [ion binding]; metal-binding site 300267009091 hypothetical protein; Provisional; Region: PRK10203 300267009092 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 300267009093 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 300267009094 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 300267009095 alphaNTD homodimer interface [polypeptide binding]; other site 300267009096 alphaNTD - beta interaction site [polypeptide binding]; other site 300267009097 alphaNTD - beta' interaction site [polypeptide binding]; other site 300267009098 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 300267009099 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 300267009100 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 300267009101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267009102 RNA binding surface [nucleotide binding]; other site 300267009103 30S ribosomal protein S11; Validated; Region: PRK05309 300267009104 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 300267009105 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 300267009106 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 300267009107 SecY translocase; Region: SecY; pfam00344 300267009108 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 300267009109 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 300267009110 23S rRNA binding site [nucleotide binding]; other site 300267009111 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 300267009112 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 300267009113 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 300267009114 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 300267009115 23S rRNA interface [nucleotide binding]; other site 300267009116 5S rRNA interface [nucleotide binding]; other site 300267009117 L27 interface [polypeptide binding]; other site 300267009118 L5 interface [polypeptide binding]; other site 300267009119 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 300267009120 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 300267009121 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 300267009122 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 300267009123 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 300267009124 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 300267009125 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 300267009126 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 300267009127 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 300267009128 RNA binding site [nucleotide binding]; other site 300267009129 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 300267009130 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 300267009131 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 300267009132 23S rRNA interface [nucleotide binding]; other site 300267009133 putative translocon interaction site; other site 300267009134 signal recognition particle (SRP54) interaction site; other site 300267009135 L23 interface [polypeptide binding]; other site 300267009136 trigger factor interaction site; other site 300267009137 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 300267009138 23S rRNA interface [nucleotide binding]; other site 300267009139 5S rRNA interface [nucleotide binding]; other site 300267009140 putative antibiotic binding site [chemical binding]; other site 300267009141 L25 interface [polypeptide binding]; other site 300267009142 L27 interface [polypeptide binding]; other site 300267009143 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 300267009144 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 300267009145 G-X-X-G motif; other site 300267009146 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 300267009147 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 300267009148 protein-rRNA interface [nucleotide binding]; other site 300267009149 putative translocon binding site; other site 300267009150 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 300267009151 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 300267009152 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 300267009153 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 300267009154 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 300267009155 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 300267009156 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 300267009157 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 300267009158 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 300267009159 Ferritin-like domain; Region: Ferritin; pfam00210 300267009160 heme binding site [chemical binding]; other site 300267009161 ferroxidase pore; other site 300267009162 ferroxidase diiron center [ion binding]; other site 300267009163 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 300267009164 elongation factor Tu; Reviewed; Region: PRK00049 300267009165 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 300267009166 G1 box; other site 300267009167 GEF interaction site [polypeptide binding]; other site 300267009168 GTP/Mg2+ binding site [chemical binding]; other site 300267009169 Switch I region; other site 300267009170 G2 box; other site 300267009171 G3 box; other site 300267009172 Switch II region; other site 300267009173 G4 box; other site 300267009174 G5 box; other site 300267009175 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 300267009176 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 300267009177 Antibiotic Binding Site [chemical binding]; other site 300267009178 elongation factor G; Reviewed; Region: PRK00007 300267009179 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 300267009180 G1 box; other site 300267009181 putative GEF interaction site [polypeptide binding]; other site 300267009182 GTP/Mg2+ binding site [chemical binding]; other site 300267009183 Switch I region; other site 300267009184 G2 box; other site 300267009185 G3 box; other site 300267009186 Switch II region; other site 300267009187 G4 box; other site 300267009188 G5 box; other site 300267009189 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 300267009190 Elongation Factor G, domain II; Region: EFG_II; pfam14492 300267009191 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 300267009192 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 300267009193 30S ribosomal protein S7; Validated; Region: PRK05302 300267009194 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 300267009195 S17 interaction site [polypeptide binding]; other site 300267009196 S8 interaction site; other site 300267009197 16S rRNA interaction site [nucleotide binding]; other site 300267009198 streptomycin interaction site [chemical binding]; other site 300267009199 23S rRNA interaction site [nucleotide binding]; other site 300267009200 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 300267009201 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 300267009202 sulfur relay protein TusC; Validated; Region: PRK00211 300267009203 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 300267009204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 300267009205 YheO-like PAS domain; Region: PAS_6; pfam08348 300267009206 HTH domain; Region: HTH_22; pfam13309 300267009207 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 300267009208 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 300267009209 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 300267009210 phi X174 lysis protein; Provisional; Region: PRK02793 300267009211 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 300267009212 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 300267009213 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 300267009214 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 300267009215 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 300267009216 TrkA-N domain; Region: TrkA_N; pfam02254 300267009217 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 300267009218 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 300267009219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267009220 ABC transporter; Region: ABC_tran_2; pfam12848 300267009221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267009222 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 300267009223 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 300267009224 putative hydrolase; Provisional; Region: PRK10985 300267009225 hypothetical protein; Provisional; Region: PRK04966 300267009226 hypothetical protein; Provisional; Region: PRK10738 300267009227 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 300267009228 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 300267009229 ligand binding site [chemical binding]; other site 300267009230 flexible hinge region; other site 300267009231 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 300267009232 putative switch regulator; other site 300267009233 non-specific DNA interactions [nucleotide binding]; other site 300267009234 DNA binding site [nucleotide binding] 300267009235 sequence specific DNA binding site [nucleotide binding]; other site 300267009236 putative cAMP binding site [chemical binding]; other site 300267009237 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 300267009238 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 300267009239 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 300267009240 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 300267009241 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 300267009242 inhibitor-cofactor binding pocket; inhibition site 300267009243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267009244 catalytic residue [active] 300267009245 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 300267009246 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 300267009247 glutamine binding [chemical binding]; other site 300267009248 catalytic triad [active] 300267009249 cell filamentation protein Fic; Provisional; Region: PRK10347 300267009250 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 300267009251 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 300267009252 substrate binding site [chemical binding]; other site 300267009253 putative transporter; Provisional; Region: PRK03699 300267009254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267009255 putative substrate translocation pore; other site 300267009256 nitrite reductase subunit NirD; Provisional; Region: PRK14989 300267009257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267009258 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 300267009259 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 300267009260 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 300267009261 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 300267009262 nitrite transporter NirC; Provisional; Region: PRK11562 300267009263 siroheme synthase; Provisional; Region: cysG; PRK10637 300267009264 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 300267009265 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 300267009266 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 300267009267 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 300267009268 active site 300267009269 SAM binding site [chemical binding]; other site 300267009270 homodimer interface [polypeptide binding]; other site 300267009271 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267009272 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 300267009273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267009274 catalytic residue [active] 300267009275 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 300267009276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267009277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267009278 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267009279 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 300267009280 MMPL family; Region: MMPL; cl14618 300267009281 MMPL family; Region: MMPL; cl14618 300267009282 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 300267009283 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 300267009284 HlyD family secretion protein; Region: HlyD_3; pfam13437 300267009285 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 300267009286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009287 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009288 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009289 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009290 acid-resistance membrane protein; Provisional; Region: PRK10209 300267009291 acid-resistance protein; Provisional; Region: PRK10208 300267009292 acid-resistance protein; Provisional; Region: hdeB; PRK11566 300267009293 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267009294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009295 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009296 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009297 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 300267009298 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 300267009299 Walker A/P-loop; other site 300267009300 ATP binding site [chemical binding]; other site 300267009301 Q-loop/lid; other site 300267009302 ABC transporter signature motif; other site 300267009303 Walker B; other site 300267009304 D-loop; other site 300267009305 H-loop/switch region; other site 300267009306 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267009307 ABC-ATPase subunit interface; other site 300267009308 dimer interface [polypeptide binding]; other site 300267009309 putative PBP binding regions; other site 300267009310 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 300267009311 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 300267009312 NAD(P) binding site [chemical binding]; other site 300267009313 putative active site [active] 300267009314 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 300267009315 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 300267009316 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 300267009317 putative hemin binding site; other site 300267009318 Uncharacterized conserved protein [Function unknown]; Region: COG5644 300267009319 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 300267009320 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267009321 N-terminal plug; other site 300267009322 ligand-binding site [chemical binding]; other site 300267009323 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 300267009324 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 300267009325 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 300267009326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 300267009327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267009328 DNA binding residues [nucleotide binding] 300267009329 dimerization interface [polypeptide binding]; other site 300267009330 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 300267009331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009332 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009333 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009334 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009335 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 300267009336 catalytic residues [active] 300267009337 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 300267009338 Citrate transporter; Region: CitMHS; pfam03600 300267009339 transmembrane helices; other site 300267009340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 300267009341 dimerization interface [polypeptide binding]; other site 300267009342 putative DNA binding site [nucleotide binding]; other site 300267009343 putative Zn2+ binding site [ion binding]; other site 300267009344 glutathione reductase; Validated; Region: PRK06116 300267009345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267009346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267009347 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 300267009348 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 300267009349 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 300267009350 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 300267009351 active site 300267009352 Zn binding site [ion binding]; other site 300267009353 putative methyltransferase; Provisional; Region: PRK10742 300267009354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267009355 S-adenosylmethionine binding site [chemical binding]; other site 300267009356 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 300267009357 Ligand Binding Site [chemical binding]; other site 300267009358 universal stress protein UspB; Provisional; Region: PRK04960 300267009359 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 300267009360 Predicted flavoproteins [General function prediction only]; Region: COG2081 300267009361 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267009362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009363 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009364 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009365 glycogen phosphorylase; Provisional; Region: PRK14986 300267009366 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 300267009367 homodimer interface [polypeptide binding]; other site 300267009368 active site pocket [active] 300267009369 glycogen synthase; Provisional; Region: glgA; PRK00654 300267009370 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 300267009371 ADP-binding pocket [chemical binding]; other site 300267009372 homodimer interface [polypeptide binding]; other site 300267009373 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 300267009374 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 300267009375 ligand binding site; other site 300267009376 oligomer interface; other site 300267009377 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 300267009378 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 300267009379 dimer interface [polypeptide binding]; other site 300267009380 N-terminal domain interface [polypeptide binding]; other site 300267009381 sulfate 1 binding site; other site 300267009382 glycogen debranching enzyme; Provisional; Region: PRK03705 300267009383 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 300267009384 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 300267009385 active site 300267009386 catalytic site [active] 300267009387 glycogen branching enzyme; Provisional; Region: PRK05402 300267009388 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 300267009389 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 300267009390 active site 300267009391 catalytic site [active] 300267009392 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 300267009393 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 300267009394 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 300267009395 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 300267009396 putative antibiotic transporter; Provisional; Region: PRK10739 300267009397 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 300267009398 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 300267009399 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 300267009400 DNA binding site [nucleotide binding] 300267009401 sequence specific DNA binding site [nucleotide binding]; other site 300267009402 putative cAMP binding site [chemical binding]; other site 300267009403 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 300267009404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009405 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009406 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009407 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267009408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009409 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009410 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009411 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009412 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 300267009413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267009414 ATP binding site [chemical binding]; other site 300267009415 putative Mg++ binding site [ion binding]; other site 300267009416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267009417 nucleotide binding region [chemical binding]; other site 300267009418 ATP-binding site [chemical binding]; other site 300267009419 low affinity gluconate transporter; Provisional; Region: PRK10472 300267009420 GntP family permease; Region: GntP_permease; pfam02447 300267009421 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 300267009422 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 300267009423 ATP-binding site [chemical binding]; other site 300267009424 Gluconate-6-phosphate binding site [chemical binding]; other site 300267009425 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 300267009426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267009427 DNA binding site [nucleotide binding] 300267009428 domain linker motif; other site 300267009429 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 300267009430 putative ligand binding site [chemical binding]; other site 300267009431 putative dimerization interface [polypeptide binding]; other site 300267009432 Pirin-related protein [General function prediction only]; Region: COG1741 300267009433 Pirin; Region: Pirin; pfam02678 300267009434 putative oxidoreductase; Provisional; Region: PRK10206 300267009435 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 300267009436 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 300267009437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009438 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009439 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009440 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 300267009441 hypothetical protein; Provisional; Region: PRK10350 300267009442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 300267009443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267009444 dimer interface [polypeptide binding]; other site 300267009445 conserved gate region; other site 300267009446 putative PBP binding loops; other site 300267009447 ABC-ATPase subunit interface; other site 300267009448 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 300267009449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267009450 dimer interface [polypeptide binding]; other site 300267009451 conserved gate region; other site 300267009452 putative PBP binding loops; other site 300267009453 ABC-ATPase subunit interface; other site 300267009454 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 300267009455 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 300267009456 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 300267009457 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 300267009458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 300267009459 binding surface 300267009460 TPR motif; other site 300267009461 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 300267009462 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 300267009463 Walker A/P-loop; other site 300267009464 ATP binding site [chemical binding]; other site 300267009465 Q-loop/lid; other site 300267009466 ABC transporter signature motif; other site 300267009467 Walker B; other site 300267009468 D-loop; other site 300267009469 H-loop/switch region; other site 300267009470 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 300267009471 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 300267009472 Walker A/P-loop; other site 300267009473 ATP binding site [chemical binding]; other site 300267009474 Q-loop/lid; other site 300267009475 ABC transporter signature motif; other site 300267009476 Walker B; other site 300267009477 D-loop; other site 300267009478 H-loop/switch region; other site 300267009479 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 300267009480 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 300267009481 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 300267009482 TM-ABC transporter signature motif; other site 300267009483 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 300267009484 TM-ABC transporter signature motif; other site 300267009485 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 300267009486 dimerization interface [polypeptide binding]; other site 300267009487 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 300267009488 ligand binding site [chemical binding]; other site 300267009489 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009491 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009492 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009493 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 300267009494 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 300267009495 dimerization interface [polypeptide binding]; other site 300267009496 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 300267009497 ligand binding site [chemical binding]; other site 300267009498 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 300267009499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 300267009500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 300267009501 DNA binding residues [nucleotide binding] 300267009502 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 300267009503 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 300267009504 cell division protein FtsE; Provisional; Region: PRK10908 300267009505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267009506 Walker A/P-loop; other site 300267009507 ATP binding site [chemical binding]; other site 300267009508 Q-loop/lid; other site 300267009509 ABC transporter signature motif; other site 300267009510 Walker B; other site 300267009511 D-loop; other site 300267009512 H-loop/switch region; other site 300267009513 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 300267009514 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 300267009515 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 300267009516 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 300267009517 P loop; other site 300267009518 GTP binding site [chemical binding]; other site 300267009519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267009520 S-adenosylmethionine binding site [chemical binding]; other site 300267009521 hypothetical protein; Provisional; Region: PRK10910 300267009522 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 300267009523 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 300267009524 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 300267009525 metal-binding site [ion binding] 300267009526 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 300267009527 Soluble P-type ATPase [General function prediction only]; Region: COG4087 300267009528 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 300267009529 CPxP motif; other site 300267009530 hypothetical protein; Provisional; Region: PRK11212 300267009531 hypothetical protein; Provisional; Region: PRK11615 300267009532 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267009533 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009535 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009536 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009537 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 300267009538 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 300267009539 dimer interface [polypeptide binding]; other site 300267009540 active site 300267009541 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 300267009542 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 300267009543 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 300267009544 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 300267009545 substrate binding site [chemical binding]; other site 300267009546 nickel transporter permease NikB; Provisional; Region: PRK10352 300267009547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267009548 dimer interface [polypeptide binding]; other site 300267009549 conserved gate region; other site 300267009550 putative PBP binding loops; other site 300267009551 ABC-ATPase subunit interface; other site 300267009552 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 300267009553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267009554 dimer interface [polypeptide binding]; other site 300267009555 conserved gate region; other site 300267009556 putative PBP binding loops; other site 300267009557 ABC-ATPase subunit interface; other site 300267009558 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 300267009559 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267009560 Walker A/P-loop; other site 300267009561 ATP binding site [chemical binding]; other site 300267009562 Q-loop/lid; other site 300267009563 ABC transporter signature motif; other site 300267009564 Walker B; other site 300267009565 D-loop; other site 300267009566 H-loop/switch region; other site 300267009567 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267009568 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 300267009569 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267009570 Walker A/P-loop; other site 300267009571 ATP binding site [chemical binding]; other site 300267009572 Q-loop/lid; other site 300267009573 ABC transporter signature motif; other site 300267009574 Walker B; other site 300267009575 D-loop; other site 300267009576 H-loop/switch region; other site 300267009577 nickel responsive regulator; Provisional; Region: PRK02967 300267009578 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 300267009579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009580 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009581 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009582 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267009583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009584 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009585 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009586 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 300267009587 active site 300267009588 phosphorylation site [posttranslational modification] 300267009589 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 300267009590 active site 300267009591 P-loop; other site 300267009592 phosphorylation site [posttranslational modification] 300267009593 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 300267009594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009595 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009596 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009597 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009598 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 300267009599 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 300267009600 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 300267009601 active site residue [active] 300267009602 intramembrane serine protease GlpG; Provisional; Region: PRK10907 300267009603 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 300267009604 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 300267009605 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 300267009606 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 300267009607 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267009608 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 300267009609 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 300267009610 putative active site [active] 300267009611 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 300267009612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 300267009613 transcriptional regulator MalT; Provisional; Region: PRK04841 300267009614 AAA ATPase domain; Region: AAA_16; pfam13191 300267009615 Cohesin loading factor; Region: Cohesin_load; pfam10345 300267009616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267009617 DNA binding residues [nucleotide binding] 300267009618 dimerization interface [polypeptide binding]; other site 300267009619 maltodextrin phosphorylase; Provisional; Region: PRK14985 300267009620 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 300267009621 homodimer interface [polypeptide binding]; other site 300267009622 active site pocket [active] 300267009623 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 300267009624 4-alpha-glucanotransferase; Region: malQ; TIGR00217 300267009625 high-affinity gluconate transporter; Provisional; Region: PRK14984 300267009626 GntP family permease; Region: GntP_permease; pfam02447 300267009627 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 300267009628 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 300267009629 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 300267009630 carboxylesterase BioH; Provisional; Region: PRK10349 300267009631 Putative lysophospholipase; Region: Hydrolase_4; cl19140 300267009632 putative transposase; Provisional; Region: PRK09857 300267009633 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 300267009634 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 300267009635 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 300267009636 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 300267009637 G1 box; other site 300267009638 GTP/Mg2+ binding site [chemical binding]; other site 300267009639 Switch I region; other site 300267009640 G2 box; other site 300267009641 G3 box; other site 300267009642 Switch II region; other site 300267009643 G4 box; other site 300267009644 G5 box; other site 300267009645 Nucleoside recognition; Region: Gate; pfam07670 300267009646 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 300267009647 Nucleoside recognition; Region: Gate; pfam07670 300267009648 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 300267009649 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 300267009650 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 300267009651 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 300267009652 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 300267009653 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 300267009654 RNA binding site [nucleotide binding]; other site 300267009655 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 300267009656 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 300267009657 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 300267009658 osmolarity response regulator; Provisional; Region: ompR; PRK09468 300267009659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267009660 active site 300267009661 phosphorylation site [posttranslational modification] 300267009662 intermolecular recognition site; other site 300267009663 dimerization interface [polypeptide binding]; other site 300267009664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267009665 DNA binding site [nucleotide binding] 300267009666 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 300267009667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267009668 dimerization interface [polypeptide binding]; other site 300267009669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267009670 dimer interface [polypeptide binding]; other site 300267009671 phosphorylation site [posttranslational modification] 300267009672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267009673 ATP binding site [chemical binding]; other site 300267009674 Mg2+ binding site [ion binding]; other site 300267009675 G-X-G motif; other site 300267009676 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 300267009677 active site 300267009678 substrate-binding site [chemical binding]; other site 300267009679 metal-binding site [ion binding] 300267009680 ATP binding site [chemical binding]; other site 300267009681 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 300267009682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009683 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009684 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009685 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 300267009686 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 300267009687 dimerization interface [polypeptide binding]; other site 300267009688 domain crossover interface; other site 300267009689 redox-dependent activation switch; other site 300267009690 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267009691 RNA binding surface [nucleotide binding]; other site 300267009692 GMP/IMP nucleotidase; Provisional; Region: PRK14988 300267009693 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 300267009694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267009695 motif II; other site 300267009696 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 300267009697 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 300267009698 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 300267009699 ADP-ribose binding site [chemical binding]; other site 300267009700 dimer interface [polypeptide binding]; other site 300267009701 active site 300267009702 nudix motif; other site 300267009703 metal binding site [ion binding]; metal-binding site 300267009704 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 300267009705 Transglycosylase; Region: Transgly; pfam00912 300267009706 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 300267009707 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 300267009708 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 300267009709 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 300267009710 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 300267009711 ADP binding site [chemical binding]; other site 300267009712 magnesium binding site [ion binding]; other site 300267009713 putative shikimate binding site; other site 300267009714 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 300267009715 active site 300267009716 dimer interface [polypeptide binding]; other site 300267009717 metal binding site [ion binding]; metal-binding site 300267009718 cell division protein DamX; Validated; Region: PRK10905 300267009719 Sporulation related domain; Region: SPOR; pfam05036 300267009720 DNA adenine methylase; Provisional; Region: PRK10904 300267009721 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 300267009722 substrate binding site [chemical binding]; other site 300267009723 hexamer interface [polypeptide binding]; other site 300267009724 metal binding site [ion binding]; metal-binding site 300267009725 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 300267009726 phosphoglycolate phosphatase; Provisional; Region: PRK13222 300267009727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267009728 motif II; other site 300267009729 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 300267009730 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 300267009731 active site 300267009732 HIGH motif; other site 300267009733 dimer interface [polypeptide binding]; other site 300267009734 KMSKS motif; other site 300267009735 Helix-turn-helix domain; Region: HTH_41; pfam14502 300267009736 YhfZ C-terminal domain; Region: YhfZ_C; pfam14503 300267009737 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267009738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267009739 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267009740 HTH-like domain; Region: HTH_21; pfam13276 300267009741 Integrase core domain; Region: rve; pfam00665 300267009742 Integrase core domain; Region: rve_3; pfam13683 300267009743 putative mutase; Provisional; Region: PRK12383 300267009744 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 300267009745 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 300267009746 active site 300267009747 substrate binding pocket [chemical binding]; other site 300267009748 homodimer interaction site [polypeptide binding]; other site 300267009749 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009751 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009752 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009753 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 300267009754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267009755 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 300267009756 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267009757 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 300267009758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267009759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267009760 homodimer interface [polypeptide binding]; other site 300267009761 catalytic residue [active] 300267009762 hypothetical protein; Provisional; Region: PRK10356 300267009763 Lysozyme subfamily 2; Region: LYZ2; smart00047 300267009764 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 300267009765 putative dimerization interface [polypeptide binding]; other site 300267009766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 300267009767 putative ligand binding site [chemical binding]; other site 300267009768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267009769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 300267009770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267009771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009772 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009773 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009774 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 300267009775 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 300267009776 purine monophosphate binding site [chemical binding]; other site 300267009777 dimer interface [polypeptide binding]; other site 300267009778 putative catalytic residues [active] 300267009779 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 300267009780 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 300267009781 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 300267009782 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 300267009783 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 300267009784 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 300267009785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267009786 active site 300267009787 phosphorylation site [posttranslational modification] 300267009788 intermolecular recognition site; other site 300267009789 dimerization interface [polypeptide binding]; other site 300267009790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267009791 Walker A motif; other site 300267009792 ATP binding site [chemical binding]; other site 300267009793 Walker B motif; other site 300267009794 arginine finger; other site 300267009795 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 300267009796 sensor protein ZraS; Provisional; Region: PRK10364 300267009797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267009798 dimer interface [polypeptide binding]; other site 300267009799 phosphorylation site [posttranslational modification] 300267009800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267009801 ATP binding site [chemical binding]; other site 300267009802 Mg2+ binding site [ion binding]; other site 300267009803 G-X-G motif; other site 300267009804 zinc resistance protein; Provisional; Region: zraP; PRK11546 300267009805 dimer interface [polypeptide binding]; other site 300267009806 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 300267009807 histone-like DNA-binding protein HU; Region: HU; cd13831 300267009808 dimer interface [polypeptide binding]; other site 300267009809 DNA binding site [nucleotide binding] 300267009810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 300267009811 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 300267009812 Active_site [active] 300267009813 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 300267009814 substrate binding site [chemical binding]; other site 300267009815 active site 300267009816 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 300267009817 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 300267009818 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 300267009819 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 300267009820 putative NADH binding site [chemical binding]; other site 300267009821 putative active site [active] 300267009822 nudix motif; other site 300267009823 putative metal binding site [ion binding]; other site 300267009824 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 300267009825 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 300267009826 ThiC-associated domain; Region: ThiC-associated; pfam13667 300267009827 ThiC family; Region: ThiC; pfam01964 300267009828 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 300267009829 thiamine phosphate binding site [chemical binding]; other site 300267009830 active site 300267009831 pyrophosphate binding site [ion binding]; other site 300267009832 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 300267009833 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 300267009834 ATP binding site [chemical binding]; other site 300267009835 substrate interface [chemical binding]; other site 300267009836 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 300267009837 thiS-thiF/thiG interaction site; other site 300267009838 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 300267009839 ThiS interaction site; other site 300267009840 putative active site [active] 300267009841 tetramer interface [polypeptide binding]; other site 300267009842 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 300267009843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267009844 FeS/SAM binding site; other site 300267009845 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 300267009846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267009847 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267009848 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267009849 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009850 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 300267009851 beta and beta' interface [polypeptide binding]; other site 300267009852 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 300267009853 beta' and sigma factor interface [polypeptide binding]; other site 300267009854 Zn-binding [ion binding]; other site 300267009855 active site region [active] 300267009856 catalytic site [active] 300267009857 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 300267009858 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 300267009859 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 300267009860 G-loop; other site 300267009861 DNA binding site [nucleotide binding] 300267009862 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 300267009863 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 300267009864 RPB12 interaction site [polypeptide binding]; other site 300267009865 RPB1 interaction site [polypeptide binding]; other site 300267009866 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 300267009867 RPB10 interaction site [polypeptide binding]; other site 300267009868 RPB11 interaction site [polypeptide binding]; other site 300267009869 RPB3 interaction site [polypeptide binding]; other site 300267009870 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 300267009871 core dimer interface [polypeptide binding]; other site 300267009872 peripheral dimer interface [polypeptide binding]; other site 300267009873 L10 interface [polypeptide binding]; other site 300267009874 L11 interface [polypeptide binding]; other site 300267009875 putative EF-Tu interaction site [polypeptide binding]; other site 300267009876 putative EF-G interaction site [polypeptide binding]; other site 300267009877 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 300267009878 23S rRNA interface [nucleotide binding]; other site 300267009879 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 300267009880 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 300267009881 mRNA/rRNA interface [nucleotide binding]; other site 300267009882 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 300267009883 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 300267009884 23S rRNA interface [nucleotide binding]; other site 300267009885 L7/L12 interface [polypeptide binding]; other site 300267009886 putative thiostrepton binding site; other site 300267009887 L25 interface [polypeptide binding]; other site 300267009888 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 300267009889 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 300267009890 putative homodimer interface [polypeptide binding]; other site 300267009891 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 300267009892 heterodimer interface [polypeptide binding]; other site 300267009893 homodimer interface [polypeptide binding]; other site 300267009894 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 300267009895 elongation factor Tu; Reviewed; Region: PRK00049 300267009896 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 300267009897 G1 box; other site 300267009898 GEF interaction site [polypeptide binding]; other site 300267009899 GTP/Mg2+ binding site [chemical binding]; other site 300267009900 Switch I region; other site 300267009901 G2 box; other site 300267009902 G3 box; other site 300267009903 Switch II region; other site 300267009904 G4 box; other site 300267009905 G5 box; other site 300267009906 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 300267009907 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 300267009908 Antibiotic Binding Site [chemical binding]; other site 300267009909 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 300267009910 ATP-binding site [chemical binding]; other site 300267009911 CoA-binding site [chemical binding]; other site 300267009912 Mg2+-binding site [ion binding]; other site 300267009913 Biotin operon repressor [Transcription]; Region: BirA; COG1654 300267009914 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 300267009915 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 300267009916 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 300267009917 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 300267009918 FAD binding domain; Region: FAD_binding_4; pfam01565 300267009919 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 300267009920 glutamate racemase; Provisional; Region: PRK00865 300267009921 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 300267009922 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267009923 N-terminal plug; other site 300267009924 ligand-binding site [chemical binding]; other site 300267009925 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 300267009926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267009927 S-adenosylmethionine binding site [chemical binding]; other site 300267009928 hypothetical protein; Provisional; Region: PRK11056 300267009929 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 300267009930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267009931 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267009932 hypothetical protein; Provisional; Region: PRK10030 300267009933 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 300267009934 dimerization interface [polypeptide binding]; other site 300267009935 DNA binding site [nucleotide binding] 300267009936 corepressor binding sites; other site 300267009937 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 300267009938 homodimer interface [polypeptide binding]; other site 300267009939 substrate-cofactor binding pocket; other site 300267009940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267009941 catalytic residue [active] 300267009942 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 300267009943 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 300267009944 putative catalytic residues [active] 300267009945 putative nucleotide binding site [chemical binding]; other site 300267009946 putative aspartate binding site [chemical binding]; other site 300267009947 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 300267009948 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 300267009949 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 300267009950 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 300267009951 FAD binding site [chemical binding]; other site 300267009952 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 300267009953 EamA-like transporter family; Region: EamA; pfam00892 300267009954 EamA-like transporter family; Region: EamA; pfam00892 300267009955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 300267009956 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 300267009957 dimer interface [polypeptide binding]; other site 300267009958 active site 300267009959 metal binding site [ion binding]; metal-binding site 300267009960 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 300267009961 active site 300267009962 intersubunit interactions; other site 300267009963 catalytic residue [active] 300267009964 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 300267009965 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 300267009966 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 300267009967 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 300267009968 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 300267009969 active site 300267009970 phosphorylation site [posttranslational modification] 300267009971 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 300267009972 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 300267009973 active site 300267009974 P-loop; other site 300267009975 phosphorylation site [posttranslational modification] 300267009976 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 300267009977 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 300267009978 dimer interface [polypeptide binding]; other site 300267009979 active site 300267009980 glycine loop; other site 300267009981 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 300267009982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267009983 FeS/SAM binding site; other site 300267009984 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 300267009985 active site 300267009986 P-loop; other site 300267009987 phosphorylation site [posttranslational modification] 300267009988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267009989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 300267009990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267009991 hypothetical protein; Provisional; Region: PRK10649 300267009992 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 300267009993 Sulfatase; Region: Sulfatase; pfam00884 300267009994 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 300267009995 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 300267009996 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 300267009997 metal binding site [ion binding]; metal-binding site 300267009998 putative dimer interface [polypeptide binding]; other site 300267009999 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 300267010000 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 300267010001 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 300267010002 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 300267010003 nucleotide binding site [chemical binding]; other site 300267010004 N-acetyl-L-glutamate binding site [chemical binding]; other site 300267010005 argininosuccinate lyase; Provisional; Region: PRK04833 300267010006 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 300267010007 active sites [active] 300267010008 tetramer interface [polypeptide binding]; other site 300267010009 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 300267010010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267010011 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 300267010012 dimerization interface [polypeptide binding]; other site 300267010013 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 300267010014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 300267010015 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 300267010016 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 300267010017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010018 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010019 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010020 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267010021 PAAR motif; Region: PAAR_motif; cl15808 300267010022 RHS Repeat; Region: RHS_repeat; pfam05593 300267010023 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 300267010024 RHS Repeat; Region: RHS_repeat; pfam05593 300267010025 RHS Repeat; Region: RHS_repeat; pfam05593 300267010026 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 300267010027 RHS Repeat; Region: RHS_repeat; pfam05593 300267010028 RHS protein; Region: RHS; pfam03527 300267010029 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 300267010030 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 300267010031 primosome assembly protein PriA; Validated; Region: PRK05580 300267010032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267010033 ATP binding site [chemical binding]; other site 300267010034 putative Mg++ binding site [ion binding]; other site 300267010035 helicase superfamily c-terminal domain; Region: HELICc; smart00490 300267010036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267010037 DNA binding site [nucleotide binding] 300267010038 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 300267010039 domain linker motif; other site 300267010040 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 300267010041 dimerization interface [polypeptide binding]; other site 300267010042 ligand binding site [chemical binding]; other site 300267010043 essential cell division protein FtsN; Provisional; Region: PRK10927 300267010044 Sporulation related domain; Region: SPOR; pfam05036 300267010045 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 300267010046 active site 300267010047 HslU subunit interaction site [polypeptide binding]; other site 300267010048 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 300267010049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267010050 Walker A motif; other site 300267010051 ATP binding site [chemical binding]; other site 300267010052 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 300267010053 Walker B motif; other site 300267010054 arginine finger; other site 300267010055 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 300267010056 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 300267010057 putative active site [active] 300267010058 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 300267010059 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267010060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010061 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010062 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010064 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010065 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010066 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267010068 Transposase; Region: HTH_Tnp_1; pfam01527 300267010069 septal ring assembly protein ZapB; Provisional; Region: PRK15422 300267010070 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 300267010071 amphipathic channel; other site 300267010072 Asn-Pro-Ala signature motifs; other site 300267010073 glycerol kinase; Provisional; Region: glpK; PRK00047 300267010074 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 300267010075 N- and C-terminal domain interface [polypeptide binding]; other site 300267010076 active site 300267010077 MgATP binding site [chemical binding]; other site 300267010078 catalytic site [active] 300267010079 metal binding site [ion binding]; metal-binding site 300267010080 glycerol binding site [chemical binding]; other site 300267010081 homotetramer interface [polypeptide binding]; other site 300267010082 homodimer interface [polypeptide binding]; other site 300267010083 FBP binding site [chemical binding]; other site 300267010084 protein IIAGlc interface [polypeptide binding]; other site 300267010085 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 300267010086 putative active site [active] 300267010087 ferredoxin-NADP reductase; Provisional; Region: PRK10926 300267010088 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 300267010089 FAD binding pocket [chemical binding]; other site 300267010090 FAD binding motif [chemical binding]; other site 300267010091 phosphate binding motif [ion binding]; other site 300267010092 beta-alpha-beta structure motif; other site 300267010093 NAD binding pocket [chemical binding]; other site 300267010094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 300267010095 Ligand Binding Site [chemical binding]; other site 300267010096 hypothetical protein; Provisional; Region: PRK09981 300267010097 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267010098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010099 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010100 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010101 Predicted membrane protein [Function unknown]; Region: COG3152 300267010102 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 300267010103 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 300267010104 substrate binding site [chemical binding]; other site 300267010105 dimer interface [polypeptide binding]; other site 300267010106 catalytic triad [active] 300267010107 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010109 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010110 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267010112 substrate binding pocket [chemical binding]; other site 300267010113 membrane-bound complex binding site; other site 300267010114 hinge residues; other site 300267010115 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 300267010116 active site 300267010117 ADP/pyrophosphate binding site [chemical binding]; other site 300267010118 dimerization interface [polypeptide binding]; other site 300267010119 allosteric effector site; other site 300267010120 fructose-1,6-bisphosphate binding site; other site 300267010121 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 300267010122 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 300267010123 dimer interface [polypeptide binding]; other site 300267010124 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 300267010125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267010126 active site 300267010127 intermolecular recognition site; other site 300267010128 dimerization interface [polypeptide binding]; other site 300267010129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267010130 DNA binding site [nucleotide binding] 300267010131 two-component sensor protein; Provisional; Region: cpxA; PRK09470 300267010132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267010133 dimerization interface [polypeptide binding]; other site 300267010134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267010135 dimer interface [polypeptide binding]; other site 300267010136 phosphorylation site [posttranslational modification] 300267010137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267010138 ATP binding site [chemical binding]; other site 300267010139 Mg2+ binding site [ion binding]; other site 300267010140 G-X-G motif; other site 300267010141 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 300267010142 MOSC domain; Region: MOSC; pfam03473 300267010143 3-alpha domain; Region: 3-alpha; pfam03475 300267010144 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 300267010145 superoxide dismutase; Provisional; Region: PRK10925 300267010146 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 300267010147 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 300267010148 Sugar transport protein; Region: Sugar_transport; cl19288 300267010149 transcriptional activator RhaR; Provisional; Region: PRK13500 300267010150 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 300267010151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267010152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267010153 transcriptional activator RhaS; Provisional; Region: PRK13503 300267010154 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 300267010155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267010156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267010157 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 300267010158 nucleotide binding site [chemical binding]; other site 300267010159 rhamnulokinase; Provisional; Region: rhaB; PRK10640 300267010160 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 300267010161 intersubunit interface [polypeptide binding]; other site 300267010162 active site 300267010163 Zn2+ binding site [ion binding]; other site 300267010164 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 300267010165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010166 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010167 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010168 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 300267010169 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 300267010170 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 300267010171 [4Fe-4S] binding site [ion binding]; other site 300267010172 molybdopterin cofactor binding site; other site 300267010173 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 300267010174 molybdopterin cofactor binding site; other site 300267010175 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 300267010176 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 300267010177 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 300267010178 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 300267010179 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 300267010180 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010182 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010183 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267010185 Coenzyme A binding pocket [chemical binding]; other site 300267010186 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 300267010187 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 300267010188 putative active site [active] 300267010189 dimerization interface [polypeptide binding]; other site 300267010190 putative tRNAtyr binding site [nucleotide binding]; other site 300267010191 hypothetical protein; Reviewed; Region: PRK01637 300267010192 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 300267010193 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 300267010194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267010195 motif II; other site 300267010196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267010197 Transposase; Region: HTH_Tnp_1; cl17663 300267010198 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 300267010199 active site 300267010200 catalytic residues [active] 300267010201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010202 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010203 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267010205 putative substrate translocation pore; other site 300267010206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010207 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010208 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010209 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010210 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267010211 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267010212 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267010213 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 300267010214 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 300267010215 G1 box; other site 300267010216 putative GEF interaction site [polypeptide binding]; other site 300267010217 GTP/Mg2+ binding site [chemical binding]; other site 300267010218 Switch I region; other site 300267010219 G2 box; other site 300267010220 G3 box; other site 300267010221 Switch II region; other site 300267010222 G4 box; other site 300267010223 G5 box; other site 300267010224 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 300267010225 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 300267010226 glutamine synthetase; Provisional; Region: glnA; PRK09469 300267010227 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 300267010228 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 300267010229 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 300267010230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 300267010231 putative active site [active] 300267010232 heme pocket [chemical binding]; other site 300267010233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267010234 dimer interface [polypeptide binding]; other site 300267010235 phosphorylation site [posttranslational modification] 300267010236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267010237 ATP binding site [chemical binding]; other site 300267010238 Mg2+ binding site [ion binding]; other site 300267010239 G-X-G motif; other site 300267010240 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 300267010241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267010242 active site 300267010243 phosphorylation site [posttranslational modification] 300267010244 intermolecular recognition site; other site 300267010245 dimerization interface [polypeptide binding]; other site 300267010246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267010247 Walker A motif; other site 300267010248 ATP binding site [chemical binding]; other site 300267010249 Walker B motif; other site 300267010250 arginine finger; other site 300267010251 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 300267010252 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 300267010253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267010254 FeS/SAM binding site; other site 300267010255 HemN C-terminal domain; Region: HemN_C; pfam06969 300267010256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 300267010257 Predicted GTPase [General function prediction only]; Region: COG0218 300267010258 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 300267010259 G1 box; other site 300267010260 GTP/Mg2+ binding site [chemical binding]; other site 300267010261 Switch I region; other site 300267010262 G2 box; other site 300267010263 G3 box; other site 300267010264 Switch II region; other site 300267010265 G4 box; other site 300267010266 G5 box; other site 300267010267 DNA polymerase I; Provisional; Region: PRK05755 300267010268 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 300267010269 active site 300267010270 metal binding site 1 [ion binding]; metal-binding site 300267010271 putative 5' ssDNA interaction site; other site 300267010272 metal binding site 3; metal-binding site 300267010273 metal binding site 2 [ion binding]; metal-binding site 300267010274 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 300267010275 putative DNA binding site [nucleotide binding]; other site 300267010276 putative metal binding site [ion binding]; other site 300267010277 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 300267010278 active site 300267010279 catalytic site [active] 300267010280 substrate binding site [chemical binding]; other site 300267010281 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 300267010282 active site 300267010283 DNA binding site [nucleotide binding] 300267010284 catalytic site [active] 300267010285 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 300267010286 putative acyl-acceptor binding pocket; other site 300267010287 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010289 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010290 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010291 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010293 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010294 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010295 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 300267010296 catalytic residues [active] 300267010297 hinge region; other site 300267010298 alpha helical domain; other site 300267010299 serine/threonine protein kinase; Provisional; Region: PRK11768 300267010300 Phosphotransferase enzyme family; Region: APH; pfam01636 300267010301 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 300267010302 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 300267010303 GTP binding site; other site 300267010304 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 300267010305 Walker A motif; other site 300267010306 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 300267010307 potassium transporter; Provisional; Region: PRK10750 300267010308 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 300267010309 hypothetical protein; Provisional; Region: PRK11568 300267010310 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 300267010311 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 300267010312 proline dipeptidase; Provisional; Region: PRK13607 300267010313 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 300267010314 active site 300267010315 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 300267010316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 300267010317 substrate binding site [chemical binding]; other site 300267010318 oxyanion hole (OAH) forming residues; other site 300267010319 trimer interface [polypeptide binding]; other site 300267010320 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 300267010321 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 300267010322 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 300267010323 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 300267010324 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 300267010325 dimer interface [polypeptide binding]; other site 300267010326 active site 300267010327 FMN reductase; Validated; Region: fre; PRK08051 300267010328 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 300267010329 FAD binding pocket [chemical binding]; other site 300267010330 FAD binding motif [chemical binding]; other site 300267010331 phosphate binding motif [ion binding]; other site 300267010332 beta-alpha-beta structure motif; other site 300267010333 NAD binding pocket [chemical binding]; other site 300267010334 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 300267010335 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 300267010336 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 300267010337 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 300267010338 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 300267010339 sec-independent translocase; Provisional; Region: PRK01770 300267010340 sec-independent translocase; Provisional; Region: tatB; PRK00404 300267010341 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 300267010342 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 300267010343 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 300267010344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 300267010345 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 300267010346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267010347 S-adenosylmethionine binding site [chemical binding]; other site 300267010348 DNA recombination protein RmuC; Provisional; Region: PRK10361 300267010349 RmuC family; Region: RmuC; pfam02646 300267010350 uridine phosphorylase; Provisional; Region: PRK11178 300267010351 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 300267010352 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 300267010353 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 300267010354 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 300267010355 THF binding site; other site 300267010356 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 300267010357 substrate binding site [chemical binding]; other site 300267010358 THF binding site; other site 300267010359 zinc-binding site [ion binding]; other site 300267010360 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 300267010361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267010362 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 300267010363 putative dimerization interface [polypeptide binding]; other site 300267010364 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 300267010365 EamA-like transporter family; Region: EamA; pfam00892 300267010366 putative hydrolase; Provisional; Region: PRK10976 300267010367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267010368 active site 300267010369 motif I; other site 300267010370 motif II; other site 300267010371 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 300267010372 lysophospholipase L2; Provisional; Region: PRK10749 300267010373 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 300267010374 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 300267010375 threonine efflux system; Provisional; Region: PRK10229 300267010376 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 300267010377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267010378 ATP binding site [chemical binding]; other site 300267010379 putative Mg++ binding site [ion binding]; other site 300267010380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267010381 nucleotide binding region [chemical binding]; other site 300267010382 ATP-binding site [chemical binding]; other site 300267010383 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 300267010384 Helicase and RNase D C-terminal; Region: HRDC; smart00341 300267010385 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 300267010386 dimerization interface [polypeptide binding]; other site 300267010387 substrate binding site [chemical binding]; other site 300267010388 active site 300267010389 calcium binding site [ion binding]; other site 300267010390 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 300267010391 CoenzymeA binding site [chemical binding]; other site 300267010392 subunit interaction site [polypeptide binding]; other site 300267010393 PHB binding site; other site 300267010394 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 300267010395 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 300267010396 Multidrug resistance efflux transporter; Region: EmrE; cl19304 300267010397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010398 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010399 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010400 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010401 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010403 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010404 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010405 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 300267010406 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 300267010407 Cl binding site [ion binding]; other site 300267010408 oligomer interface [polypeptide binding]; other site 300267010409 Predicted periplasmic protein [Function unknown]; Region: COG3698 300267010410 Uncharacterized conserved protein [Function unknown]; Region: COG1912 300267010411 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 300267010412 Part of AAA domain; Region: AAA_19; pfam13245 300267010413 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 300267010414 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 300267010415 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 300267010416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267010417 motif II; other site 300267010418 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 300267010419 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 300267010420 active site 300267010421 Int/Topo IB signature motif; other site 300267010422 hypothetical protein; Provisional; Region: PRK10963 300267010423 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 300267010424 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 300267010425 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 300267010426 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 300267010427 hypothetical protein; Provisional; Region: PRK09807 300267010428 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 300267010429 putative iron binding site [ion binding]; other site 300267010430 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 300267010431 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 300267010432 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 300267010433 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 300267010434 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 300267010435 domain interfaces; other site 300267010436 active site 300267010437 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 300267010438 active site 300267010439 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 300267010440 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 300267010441 HemY protein N-terminus; Region: HemY_N; pfam07219 300267010442 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 300267010443 Sulfatase; Region: Sulfatase; pfam00884 300267010444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010445 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010446 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010447 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267010448 putative transport protein YifK; Provisional; Region: PRK10746 300267010449 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 300267010450 putative common antigen polymerase; Provisional; Region: PRK02975 300267010451 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 300267010452 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 300267010453 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 300267010454 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 300267010455 inhibitor-cofactor binding pocket; inhibition site 300267010456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267010457 catalytic residue [active] 300267010458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 300267010459 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 300267010460 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 300267010461 substrate binding site; other site 300267010462 tetramer interface; other site 300267010463 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 300267010464 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 300267010465 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 300267010466 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 300267010467 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 300267010468 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 300267010469 active site 300267010470 homodimer interface [polypeptide binding]; other site 300267010471 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 300267010472 Chain length determinant protein; Region: Wzz; pfam02706 300267010473 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 300267010474 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 300267010475 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 300267010476 Mg++ binding site [ion binding]; other site 300267010477 putative catalytic motif [active] 300267010478 substrate binding site [chemical binding]; other site 300267010479 transcription termination factor Rho; Provisional; Region: rho; PRK09376 300267010480 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 300267010481 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 300267010482 RNA binding site [nucleotide binding]; other site 300267010483 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 300267010484 multimer interface [polypeptide binding]; other site 300267010485 Walker A motif; other site 300267010486 ATP binding site [chemical binding]; other site 300267010487 Walker B motif; other site 300267010488 putative rho operon leader peptide; Provisional; Region: PRK09979 300267010489 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 300267010490 catalytic residues [active] 300267010491 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 300267010492 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 300267010493 ATP binding site [chemical binding]; other site 300267010494 Mg++ binding site [ion binding]; other site 300267010495 motif III; other site 300267010496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267010497 nucleotide binding region [chemical binding]; other site 300267010498 ATP-binding site [chemical binding]; other site 300267010499 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 300267010500 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 300267010501 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 300267010502 Part of AAA domain; Region: AAA_19; pfam13245 300267010503 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 300267010504 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267010505 HTH-like domain; Region: HTH_21; pfam13276 300267010506 Integrase core domain; Region: rve; pfam00665 300267010507 Integrase core domain; Region: rve_3; pfam13683 300267010508 PemK-like protein; Region: PemK; cl00995 300267010509 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 300267010510 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 300267010511 ketol-acid reductoisomerase; Validated; Region: PRK05225 300267010512 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 300267010513 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 300267010514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267010515 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 300267010516 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 300267010517 putative dimerization interface [polypeptide binding]; other site 300267010518 threonine dehydratase; Reviewed; Region: PRK09224 300267010519 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 300267010520 tetramer interface [polypeptide binding]; other site 300267010521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267010522 catalytic residue [active] 300267010523 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 300267010524 putative Ile/Val binding site [chemical binding]; other site 300267010525 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 300267010526 putative Ile/Val binding site [chemical binding]; other site 300267010527 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 300267010528 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 300267010529 homodimer interface [polypeptide binding]; other site 300267010530 substrate-cofactor binding pocket; other site 300267010531 catalytic residue [active] 300267010532 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 300267010533 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 300267010534 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 300267010535 PYR/PP interface [polypeptide binding]; other site 300267010536 dimer interface [polypeptide binding]; other site 300267010537 TPP binding site [chemical binding]; other site 300267010538 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 300267010539 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 300267010540 TPP-binding site [chemical binding]; other site 300267010541 dimer interface [polypeptide binding]; other site 300267010542 ilvG operon leader peptide; Provisional; Region: PRK10424 300267010543 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267010544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267010545 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 300267010546 hypothetical protein; Provisional; Region: PRK11027 300267010547 transcriptional regulator HdfR; Provisional; Region: PRK03601 300267010548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267010549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 300267010550 dimerization interface [polypeptide binding]; other site 300267010551 Transcriptional regulators [Transcription]; Region: FadR; COG2186 300267010552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267010553 DNA-binding site [nucleotide binding]; DNA binding site 300267010554 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 300267010555 putative transporter; Provisional; Region: PRK10504 300267010556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267010557 putative substrate translocation pore; other site 300267010558 transcriptional repressor RbsR; Provisional; Region: PRK10423 300267010559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267010560 DNA binding site [nucleotide binding] 300267010561 domain linker motif; other site 300267010562 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 300267010563 dimerization interface [polypeptide binding]; other site 300267010564 ligand binding site [chemical binding]; other site 300267010565 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 300267010566 substrate binding site [chemical binding]; other site 300267010567 dimer interface [polypeptide binding]; other site 300267010568 ATP binding site [chemical binding]; other site 300267010569 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 300267010570 TM-ABC transporter signature motif; other site 300267010571 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010573 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010574 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010575 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 300267010576 regulatory ATPase RavA; Provisional; Region: PRK13531 300267010577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267010578 Walker A motif; other site 300267010579 ATP binding site [chemical binding]; other site 300267010580 Walker B motif; other site 300267010581 arginine finger; other site 300267010582 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 300267010583 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 300267010584 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 300267010585 metal ion-dependent adhesion site (MIDAS); other site 300267010586 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 300267010587 dimer interface [polypeptide binding]; other site 300267010588 active site 300267010589 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 300267010590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 300267010591 putative DNA binding site [nucleotide binding]; other site 300267010592 putative Zn2+ binding site [ion binding]; other site 300267010593 AsnC family; Region: AsnC_trans_reg; pfam01037 300267010594 FMN-binding protein MioC; Provisional; Region: PRK09004 300267010595 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 300267010596 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 300267010597 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 300267010598 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 300267010599 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 300267010600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267010601 S-adenosylmethionine binding site [chemical binding]; other site 300267010602 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 300267010603 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 300267010604 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 300267010605 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 300267010606 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 300267010607 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 300267010608 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 300267010609 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 300267010610 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 300267010611 beta subunit interaction interface [polypeptide binding]; other site 300267010612 Walker A motif; other site 300267010613 ATP binding site [chemical binding]; other site 300267010614 Walker B motif; other site 300267010615 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 300267010616 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 300267010617 core domain interface [polypeptide binding]; other site 300267010618 delta subunit interface [polypeptide binding]; other site 300267010619 epsilon subunit interface [polypeptide binding]; other site 300267010620 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 300267010621 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 300267010622 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 300267010623 alpha subunit interaction interface [polypeptide binding]; other site 300267010624 Walker A motif; other site 300267010625 ATP binding site [chemical binding]; other site 300267010626 Walker B motif; other site 300267010627 inhibitor binding site; inhibition site 300267010628 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 300267010629 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 300267010630 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 300267010631 gamma subunit interface [polypeptide binding]; other site 300267010632 epsilon subunit interface [polypeptide binding]; other site 300267010633 LBP interface [polypeptide binding]; other site 300267010634 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 300267010635 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 300267010636 Substrate binding site; other site 300267010637 Mg++ binding site; other site 300267010638 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 300267010639 active site 300267010640 substrate binding site [chemical binding]; other site 300267010641 CoA binding site [chemical binding]; other site 300267010642 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 300267010643 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 300267010644 glutaminase active site [active] 300267010645 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 300267010646 dimer interface [polypeptide binding]; other site 300267010647 active site 300267010648 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 300267010649 dimer interface [polypeptide binding]; other site 300267010650 active site 300267010651 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 300267010652 Putative transposase; Region: Y2_Tnp; pfam04986 300267010653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 300267010654 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267010655 substrate binding pocket [chemical binding]; other site 300267010656 membrane-bound complex binding site; other site 300267010657 hinge residues; other site 300267010658 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 300267010659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267010660 dimer interface [polypeptide binding]; other site 300267010661 conserved gate region; other site 300267010662 putative PBP binding loops; other site 300267010663 ABC-ATPase subunit interface; other site 300267010664 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 300267010665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267010666 dimer interface [polypeptide binding]; other site 300267010667 conserved gate region; other site 300267010668 putative PBP binding loops; other site 300267010669 ABC-ATPase subunit interface; other site 300267010670 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 300267010671 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 300267010672 Walker A/P-loop; other site 300267010673 ATP binding site [chemical binding]; other site 300267010674 Q-loop/lid; other site 300267010675 ABC transporter signature motif; other site 300267010676 Walker B; other site 300267010677 D-loop; other site 300267010678 H-loop/switch region; other site 300267010679 transcriptional regulator PhoU; Provisional; Region: PRK11115 300267010680 PhoU domain; Region: PhoU; pfam01895 300267010681 PhoU domain; Region: PhoU; pfam01895 300267010682 Salmonella outer protein D; Region: SopD; cl14701 300267010683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010684 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010685 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010686 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010688 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010689 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010690 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 300267010691 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 300267010692 trimer interface [polypeptide binding]; other site 300267010693 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 300267010694 trimer interface [polypeptide binding]; other site 300267010695 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 300267010696 trimer interface [polypeptide binding]; other site 300267010697 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 300267010698 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 300267010699 trimer interface [polypeptide binding]; other site 300267010700 fibritin; Provisional; Region: wac; PHA02607 300267010701 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 300267010702 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 300267010703 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 300267010704 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 300267010705 L-lactate permease; Provisional; Region: PRK10420 300267010706 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 300267010707 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267010708 DNA-binding site [nucleotide binding]; DNA binding site 300267010709 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 300267010710 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 300267010711 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 300267010712 active site 300267010713 substrate binding site [chemical binding]; other site 300267010714 FMN binding site [chemical binding]; other site 300267010715 putative catalytic residues [active] 300267010716 putative rRNA methylase; Provisional; Region: PRK10358 300267010717 serine acetyltransferase; Provisional; Region: cysE; PRK11132 300267010718 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 300267010719 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 300267010720 trimer interface [polypeptide binding]; other site 300267010721 active site 300267010722 substrate binding site [chemical binding]; other site 300267010723 CoA binding site [chemical binding]; other site 300267010724 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 300267010725 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 300267010726 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 300267010727 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 300267010728 SecA binding site; other site 300267010729 Preprotein binding site; other site 300267010730 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 300267010731 GSH binding site [chemical binding]; other site 300267010732 catalytic residues [active] 300267010733 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 300267010734 active site residue [active] 300267010735 phosphoglyceromutase; Provisional; Region: PRK05434 300267010736 AmiB activator; Provisional; Region: PRK11637 300267010737 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 300267010738 HemX; Region: HemX; cl19375 300267010739 Peptidase family M23; Region: Peptidase_M23; pfam01551 300267010740 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 300267010741 putative active site [active] 300267010742 NodB motif; other site 300267010743 putative glycosyl transferase; Provisional; Region: PRK10073 300267010744 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 300267010745 active site 300267010746 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 300267010747 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 300267010748 NAD(P) binding site [chemical binding]; other site 300267010749 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 300267010750 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 300267010751 substrate-cofactor binding pocket; other site 300267010752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267010753 catalytic residue [active] 300267010754 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 300267010755 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 300267010756 NADP binding site [chemical binding]; other site 300267010757 homopentamer interface [polypeptide binding]; other site 300267010758 substrate binding site [chemical binding]; other site 300267010759 active site 300267010760 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 300267010761 putative active site [active] 300267010762 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 300267010763 putative active site [active] 300267010764 O-Antigen ligase; Region: Wzy_C; pfam04932 300267010765 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 300267010766 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 300267010767 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 300267010768 Ligand binding site; other site 300267010769 metal-binding site 300267010770 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 300267010771 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 300267010772 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 300267010773 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 300267010774 Ligand binding site; other site 300267010775 metal-binding site 300267010776 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 300267010777 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 300267010778 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 300267010779 Ligand binding site; other site 300267010780 metal-binding site 300267010781 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 300267010782 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 300267010783 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 300267010784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 300267010785 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 300267010786 putative active site [active] 300267010787 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 300267010788 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 300267010789 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 300267010790 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 300267010791 active site 300267010792 (T/H)XGH motif; other site 300267010793 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 300267010794 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 300267010795 DNA binding site [nucleotide binding] 300267010796 catalytic residue [active] 300267010797 H2TH interface [polypeptide binding]; other site 300267010798 putative catalytic residues [active] 300267010799 turnover-facilitating residue; other site 300267010800 intercalation triad [nucleotide binding]; other site 300267010801 8OG recognition residue [nucleotide binding]; other site 300267010802 putative reading head residues; other site 300267010803 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 300267010804 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 300267010805 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 300267010806 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 300267010807 hypothetical protein; Reviewed; Region: PRK00024 300267010808 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 300267010809 MPN+ (JAMM) motif; other site 300267010810 Zinc-binding site [ion binding]; other site 300267010811 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 300267010812 Flavoprotein; Region: Flavoprotein; cl19190 300267010813 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 300267010814 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 300267010815 trimer interface [polypeptide binding]; other site 300267010816 active site 300267010817 division inhibitor protein; Provisional; Region: slmA; PRK09480 300267010818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267010819 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 300267010820 active site 300267010821 ribonuclease PH; Reviewed; Region: rph; PRK00173 300267010822 Ribonuclease PH; Region: RNase_PH_bact; cd11362 300267010823 hexamer interface [polypeptide binding]; other site 300267010824 active site 300267010825 hypothetical protein; Provisional; Region: PRK11820 300267010826 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 300267010827 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 300267010828 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 300267010829 BRO family, N-terminal domain; Region: Bro-N; pfam02498 300267010830 Predicted membrane protein [Function unknown]; Region: COG2860 300267010831 UPF0126 domain; Region: UPF0126; pfam03458 300267010832 UPF0126 domain; Region: UPF0126; pfam03458 300267010833 Guanylate kinase; Region: Guanylate_kin; pfam00625 300267010834 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 300267010835 catalytic site [active] 300267010836 G-X2-G-X-G-K; other site 300267010837 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 300267010838 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 300267010839 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 300267010840 Zn2+ binding site [ion binding]; other site 300267010841 Mg2+ binding site [ion binding]; other site 300267010842 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 300267010843 synthetase active site [active] 300267010844 NTP binding site [chemical binding]; other site 300267010845 metal binding site [ion binding]; metal-binding site 300267010846 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 300267010847 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 300267010848 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 300267010849 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 300267010850 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 300267010851 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 300267010852 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 300267010853 generic binding surface II; other site 300267010854 ssDNA binding site; other site 300267010855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 300267010856 ATP binding site [chemical binding]; other site 300267010857 putative Mg++ binding site [ion binding]; other site 300267010858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 300267010859 nucleotide binding region [chemical binding]; other site 300267010860 ATP-binding site [chemical binding]; other site 300267010861 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 300267010862 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 300267010863 Sulfate transporter family; Region: Sulfate_transp; cl19250 300267010864 AsmA family; Region: AsmA; pfam05170 300267010865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267010866 Transposase; Region: HTH_Tnp_1; pfam01527 300267010867 alpha-galactosidase; Provisional; Region: PRK15076 300267010868 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 300267010869 NAD binding site [chemical binding]; other site 300267010870 sugar binding site [chemical binding]; other site 300267010871 divalent metal binding site [ion binding]; other site 300267010872 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 300267010873 dimer interface [polypeptide binding]; other site 300267010874 arginine decarboxylase; Provisional; Region: PRK15029 300267010875 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 300267010876 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 300267010877 homodimer interface [polypeptide binding]; other site 300267010878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267010879 catalytic residue [active] 300267010880 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 300267010881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010882 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010883 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010884 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267010886 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 300267010887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267010888 arginine:agmatin antiporter; Provisional; Region: PRK10644 300267010889 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267010890 putative metal dependent hydrolase; Provisional; Region: PRK11598 300267010891 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 300267010892 Sulfatase; Region: Sulfatase; pfam00884 300267010893 sensor protein BasS/PmrB; Provisional; Region: PRK10755 300267010894 HAMP domain; Region: HAMP; pfam00672 300267010895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267010896 dimer interface [polypeptide binding]; other site 300267010897 phosphorylation site [posttranslational modification] 300267010898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267010899 ATP binding site [chemical binding]; other site 300267010900 Mg2+ binding site [ion binding]; other site 300267010901 G-X-G motif; other site 300267010902 proline/glycine betaine transporter; Provisional; Region: PRK10642 300267010903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267010904 putative substrate translocation pore; other site 300267010905 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 300267010906 YjcZ-like protein; Region: YjcZ; pfam13990 300267010907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010908 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010909 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010910 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010911 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267010912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267010913 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267010914 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267010915 hypothetical protein; Provisional; Region: PRK10220 300267010916 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 300267010917 PhnA protein; Region: PhnA; pfam03831 300267010918 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 300267010919 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 300267010920 Walker A/P-loop; other site 300267010921 ATP binding site [chemical binding]; other site 300267010922 Q-loop/lid; other site 300267010923 ABC transporter signature motif; other site 300267010924 Walker B; other site 300267010925 D-loop; other site 300267010926 H-loop/switch region; other site 300267010927 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 300267010928 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 300267010929 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 300267010930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267010931 dimer interface [polypeptide binding]; other site 300267010932 conserved gate region; other site 300267010933 putative PBP binding loops; other site 300267010934 ABC-ATPase subunit interface; other site 300267010935 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 300267010936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267010937 DNA-binding site [nucleotide binding]; DNA binding site 300267010938 UTRA domain; Region: UTRA; pfam07702 300267010939 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 300267010940 Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; cl01456 300267010941 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 300267010942 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 300267010943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267010944 Walker A/P-loop; other site 300267010945 ATP binding site [chemical binding]; other site 300267010946 Q-loop/lid; other site 300267010947 ABC transporter signature motif; other site 300267010948 Walker B; other site 300267010949 D-loop; other site 300267010950 H-loop/switch region; other site 300267010951 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267010952 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 300267010953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267010954 Walker A/P-loop; other site 300267010955 ATP binding site [chemical binding]; other site 300267010956 Q-loop/lid; other site 300267010957 ABC transporter signature motif; other site 300267010958 Walker B; other site 300267010959 D-loop; other site 300267010960 H-loop/switch region; other site 300267010961 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 300267010962 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 300267010963 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 300267010964 active site 300267010965 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 300267010966 Guanylate kinase; Region: Guanylate_kin; pfam00625 300267010967 active site 300267010968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267010969 Coenzyme A binding pocket [chemical binding]; other site 300267010970 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 300267010971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267010972 Coenzyme A binding pocket [chemical binding]; other site 300267010973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 300267010974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 300267010975 dimerization interface [polypeptide binding]; other site 300267010976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267010977 dimer interface [polypeptide binding]; other site 300267010978 phosphorylation site [posttranslational modification] 300267010979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267010980 ATP binding site [chemical binding]; other site 300267010981 Mg2+ binding site [ion binding]; other site 300267010982 G-X-G motif; other site 300267010983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267010984 active site 300267010985 phosphorylation site [posttranslational modification] 300267010986 intermolecular recognition site; other site 300267010987 dimerization interface [polypeptide binding]; other site 300267010988 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 300267010989 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 300267010990 Walker A/P-loop; other site 300267010991 ATP binding site [chemical binding]; other site 300267010992 Q-loop/lid; other site 300267010993 ABC transporter signature motif; other site 300267010994 Walker B; other site 300267010995 D-loop; other site 300267010996 H-loop/switch region; other site 300267010997 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 300267010998 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 300267010999 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 300267011000 putative ligand binding site [chemical binding]; other site 300267011001 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 300267011002 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 300267011003 intersubunit interface [polypeptide binding]; other site 300267011004 active site 300267011005 zinc binding site [ion binding]; other site 300267011006 Na+ binding site [ion binding]; other site 300267011007 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 300267011008 substrate binding site [chemical binding]; other site 300267011009 ATP binding site [chemical binding]; other site 300267011010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 300267011011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267011012 active site 300267011013 phosphorylation site [posttranslational modification] 300267011014 intermolecular recognition site; other site 300267011015 dimerization interface [polypeptide binding]; other site 300267011016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267011017 DNA binding site [nucleotide binding] 300267011018 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011020 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011021 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011022 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 300267011023 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 300267011024 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 300267011025 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 300267011026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011027 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011028 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011029 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011030 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 300267011031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267011032 putative substrate translocation pore; other site 300267011033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 300267011034 Predicted transcriptional regulator [Transcription]; Region: COG2944 300267011035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267011036 non-specific DNA binding site [nucleotide binding]; other site 300267011037 salt bridge; other site 300267011038 sequence-specific DNA binding site [nucleotide binding]; other site 300267011039 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 300267011040 cryptic adenine deaminase; Provisional; Region: PRK10027 300267011041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 300267011042 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 300267011043 active site 300267011044 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 300267011045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267011046 putative substrate translocation pore; other site 300267011047 regulatory protein UhpC; Provisional; Region: PRK11663 300267011048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267011049 putative substrate translocation pore; other site 300267011050 sensory histidine kinase UhpB; Provisional; Region: PRK11644 300267011051 MASE1; Region: MASE1; pfam05231 300267011052 Histidine kinase; Region: HisKA_3; pfam07730 300267011053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267011054 ATP binding site [chemical binding]; other site 300267011055 Mg2+ binding site [ion binding]; other site 300267011056 G-X-G motif; other site 300267011057 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 300267011058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267011059 active site 300267011060 phosphorylation site [posttranslational modification] 300267011061 intermolecular recognition site; other site 300267011062 dimerization interface [polypeptide binding]; other site 300267011063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267011064 DNA binding residues [nucleotide binding] 300267011065 dimerization interface [polypeptide binding]; other site 300267011066 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011067 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011069 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011070 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011071 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 300267011072 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 300267011073 putative valine binding site [chemical binding]; other site 300267011074 dimer interface [polypeptide binding]; other site 300267011075 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 300267011076 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 300267011077 PYR/PP interface [polypeptide binding]; other site 300267011078 dimer interface [polypeptide binding]; other site 300267011079 TPP binding site [chemical binding]; other site 300267011080 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 300267011081 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 300267011082 TPP-binding site [chemical binding]; other site 300267011083 dimer interface [polypeptide binding]; other site 300267011084 ilvB operon leader peptide; Provisional; Region: PRK10214 300267011085 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 300267011086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267011087 putative substrate translocation pore; other site 300267011088 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 300267011089 Domain of unknown function (DUF202); Region: DUF202; pfam02656 300267011090 Predicted membrane protein [Function unknown]; Region: COG2149 300267011091 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 300267011092 Sulfatase; Region: Sulfatase; pfam00884 300267011093 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011095 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011096 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011098 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011099 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011100 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011101 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 300267011102 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 300267011103 NAD binding site [chemical binding]; other site 300267011104 sugar binding site [chemical binding]; other site 300267011105 divalent metal binding site [ion binding]; other site 300267011106 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 300267011107 dimer interface [polypeptide binding]; other site 300267011108 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 300267011109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267011110 DNA-binding site [nucleotide binding]; DNA binding site 300267011111 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 300267011112 putative transporter; Validated; Region: PRK03818 300267011113 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 300267011114 TrkA-C domain; Region: TrkA_C; pfam02080 300267011115 TrkA-C domain; Region: TrkA_C; pfam02080 300267011116 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 300267011117 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 300267011118 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 300267011119 putative dimer interface [polypeptide binding]; other site 300267011120 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 300267011121 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 300267011122 putative dimer interface [polypeptide binding]; other site 300267011123 hypothetical protein; Provisional; Region: PRK11616 300267011124 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 300267011125 putative oxidoreductase; Provisional; Region: PRK11445 300267011126 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 300267011127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011128 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011129 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011130 sugar phosphate phosphatase; Provisional; Region: PRK10513 300267011131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267011132 active site 300267011133 motif I; other site 300267011134 motif II; other site 300267011135 hypothetical protein; Provisional; Region: PRK11426 300267011136 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 300267011137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267011138 ATP binding site [chemical binding]; other site 300267011139 Mg2+ binding site [ion binding]; other site 300267011140 G-X-G motif; other site 300267011141 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 300267011142 anchoring element; other site 300267011143 dimer interface [polypeptide binding]; other site 300267011144 ATP binding site [chemical binding]; other site 300267011145 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 300267011146 active site 300267011147 putative metal-binding site [ion binding]; other site 300267011148 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 300267011149 recF protein; Region: recf; TIGR00611 300267011150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 300267011151 Walker A/P-loop; other site 300267011152 ATP binding site [chemical binding]; other site 300267011153 Q-loop/lid; other site 300267011154 ABC transporter signature motif; other site 300267011155 Walker B; other site 300267011156 D-loop; other site 300267011157 H-loop/switch region; other site 300267011158 DNA polymerase III subunit beta; Validated; Region: PRK05643 300267011159 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 300267011160 putative DNA binding surface [nucleotide binding]; other site 300267011161 dimer interface [polypeptide binding]; other site 300267011162 beta-clamp/clamp loader binding surface; other site 300267011163 beta-clamp/translesion DNA polymerase binding surface; other site 300267011164 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 300267011165 DnaA N-terminal domain; Region: DnaA_N; pfam11638 300267011166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267011167 Walker A motif; other site 300267011168 ATP binding site [chemical binding]; other site 300267011169 Walker B motif; other site 300267011170 arginine finger; other site 300267011171 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 300267011172 DnaA box-binding interface [nucleotide binding]; other site 300267011173 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 300267011174 ribonuclease P; Reviewed; Region: rnpA; PRK01732 300267011175 hypothetical protein; Validated; Region: PRK00041 300267011176 membrane protein insertase; Provisional; Region: PRK01318 300267011177 YidC periplasmic domain; Region: YidC_periplas; pfam14849 300267011178 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 300267011179 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 300267011180 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 300267011181 trmE is a tRNA modification GTPase; Region: trmE; cd04164 300267011182 G1 box; other site 300267011183 GTP/Mg2+ binding site [chemical binding]; other site 300267011184 Switch I region; other site 300267011185 G2 box; other site 300267011186 Switch II region; other site 300267011187 G3 box; other site 300267011188 G4 box; other site 300267011189 G5 box; other site 300267011190 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 300267011191 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011193 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011194 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011195 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011197 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011198 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267011200 Transposase; Region: HTH_Tnp_1; pfam01527 300267011201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011202 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011203 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011204 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011205 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 300267011206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267011207 active site 300267011208 motif I; other site 300267011209 motif II; other site 300267011210 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 300267011211 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 300267011212 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 300267011213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267011214 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 300267011215 substrate binding pocket [chemical binding]; other site 300267011216 dimerization interface [polypeptide binding]; other site 300267011217 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 300267011218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267011219 putative substrate translocation pore; other site 300267011220 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 300267011221 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 300267011222 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267011223 HTH-like domain; Region: HTH_21; pfam13276 300267011224 Integrase core domain; Region: rve; pfam00665 300267011225 Integrase core domain; Region: rve_3; pfam13683 300267011226 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267011227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267011228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011229 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011230 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011231 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011232 PAAR motif; Region: PAAR_motif; cl15808 300267011233 RHS Repeat; Region: RHS_repeat; pfam05593 300267011234 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 300267011235 RHS Repeat; Region: RHS_repeat; pfam05593 300267011236 RHS Repeat; Region: RHS_repeat; pfam05593 300267011237 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 300267011238 RHS Repeat; Region: RHS_repeat; pfam05593 300267011239 RHS protein; Region: RHS; pfam03527 300267011240 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 300267011241 putative glutathione S-transferase; Provisional; Region: PRK10357 300267011242 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 300267011243 putative C-terminal domain interface [polypeptide binding]; other site 300267011244 putative GSH binding site (G-site) [chemical binding]; other site 300267011245 putative dimer interface [polypeptide binding]; other site 300267011246 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 300267011247 dimer interface [polypeptide binding]; other site 300267011248 N-terminal domain interface [polypeptide binding]; other site 300267011249 putative substrate binding pocket (H-site) [chemical binding]; other site 300267011250 selenocysteine synthase; Provisional; Region: PRK04311 300267011251 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 300267011252 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 300267011253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 300267011254 catalytic residue [active] 300267011255 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 300267011256 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 300267011257 G1 box; other site 300267011258 putative GEF interaction site [polypeptide binding]; other site 300267011259 GTP/Mg2+ binding site [chemical binding]; other site 300267011260 Switch I region; other site 300267011261 G2 box; other site 300267011262 G3 box; other site 300267011263 Switch II region; other site 300267011264 G4 box; other site 300267011265 G5 box; other site 300267011266 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 300267011267 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 300267011268 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 300267011269 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 300267011270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011271 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011272 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011274 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011275 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011276 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011277 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 300267011278 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 300267011279 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 300267011280 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 300267011281 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011283 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011284 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011285 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 300267011286 Putative transposase; Region: Y2_Tnp; pfam04986 300267011287 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 300267011288 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 300267011289 active site 300267011290 dimer interface [polypeptide binding]; other site 300267011291 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 300267011292 dimer interface [polypeptide binding]; other site 300267011293 active site 300267011294 aspartate kinase III; Validated; Region: PRK09084 300267011295 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 300267011296 nucleotide binding site [chemical binding]; other site 300267011297 putative catalytic residues [active] 300267011298 aspartate binding site [chemical binding]; other site 300267011299 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 300267011300 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 300267011301 dimer interface [polypeptide binding]; other site 300267011302 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267011303 HTH-like domain; Region: HTH_21; pfam13276 300267011304 Integrase core domain; Region: rve; pfam00665 300267011305 Integrase core domain; Region: rve_3; pfam13683 300267011306 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267011307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267011308 fumarate hydratase FumB; Provisional; Region: PRK15391 300267011309 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 300267011310 Fumarase C-terminus; Region: Fumerase_C; pfam05683 300267011311 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 300267011312 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011314 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011315 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011316 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011318 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011319 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011320 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 300267011321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267011322 active site 300267011323 phosphorylation site [posttranslational modification] 300267011324 intermolecular recognition site; other site 300267011325 dimerization interface [polypeptide binding]; other site 300267011326 sensory histidine kinase DcuS; Provisional; Region: PRK11086 300267011327 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 300267011328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 300267011329 putative active site [active] 300267011330 heme pocket [chemical binding]; other site 300267011331 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 300267011332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267011333 ATP binding site [chemical binding]; other site 300267011334 Mg2+ binding site [ion binding]; other site 300267011335 G-X-G motif; other site 300267011336 Uncharacterized conserved protein [Function unknown]; Region: COG3592 300267011337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267011338 Coenzyme A binding pocket [chemical binding]; other site 300267011339 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011341 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011342 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011343 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011344 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011346 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011347 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011349 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011350 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011351 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011352 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 300267011353 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 300267011354 Walker A/P-loop; other site 300267011355 ATP binding site [chemical binding]; other site 300267011356 Q-loop/lid; other site 300267011357 ABC transporter signature motif; other site 300267011358 Walker B; other site 300267011359 D-loop; other site 300267011360 H-loop/switch region; other site 300267011361 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 300267011362 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 300267011363 TM-ABC transporter signature motif; other site 300267011364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 300267011365 TM-ABC transporter signature motif; other site 300267011366 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 300267011367 AMP binding site [chemical binding]; other site 300267011368 metal binding site [ion binding]; metal-binding site 300267011369 active site 300267011370 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 300267011371 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 300267011372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 300267011373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 300267011374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 300267011375 peptidase PmbA; Provisional; Region: PRK11040 300267011376 cytochrome b562; Provisional; Region: PRK15058 300267011377 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 300267011378 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 300267011379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267011380 FeS/SAM binding site; other site 300267011381 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 300267011382 ATP cone domain; Region: ATP-cone; pfam03477 300267011383 Class III ribonucleotide reductase; Region: RNR_III; cd01675 300267011384 effector binding site; other site 300267011385 active site 300267011386 Zn binding site [ion binding]; other site 300267011387 glycine loop; other site 300267011388 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 300267011389 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 300267011390 Ca binding site [ion binding]; other site 300267011391 active site 300267011392 catalytic site [active] 300267011393 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 300267011394 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 300267011395 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 300267011396 active site turn [active] 300267011397 phosphorylation site [posttranslational modification] 300267011398 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 300267011399 trehalose repressor; Provisional; Region: treR; PRK09492 300267011400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 300267011401 DNA binding site [nucleotide binding] 300267011402 domain linker motif; other site 300267011403 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 300267011404 dimerization interface [polypeptide binding]; other site 300267011405 ligand binding site [chemical binding]; other site 300267011406 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 300267011407 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 300267011408 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 300267011409 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 300267011410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267011411 motif II; other site 300267011412 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 300267011413 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 300267011414 homotrimer interaction site [polypeptide binding]; other site 300267011415 putative active site [active] 300267011416 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 300267011417 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 300267011418 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 300267011419 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 300267011420 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 300267011421 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 300267011422 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 300267011423 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 300267011424 homotrimer interaction site [polypeptide binding]; other site 300267011425 putative active site [active] 300267011426 oxidoreductase; Provisional; Region: PRK12742 300267011427 classical (c) SDRs; Region: SDR_c; cd05233 300267011428 NAD(P) binding site [chemical binding]; other site 300267011429 active site 300267011430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 300267011431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 300267011432 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 300267011433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011434 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011435 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011437 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011438 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011439 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011440 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267011441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267011442 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267011443 HTH-like domain; Region: HTH_21; pfam13276 300267011444 Integrase core domain; Region: rve; pfam00665 300267011445 Integrase core domain; Region: rve_3; pfam13683 300267011446 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 300267011447 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 300267011448 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 300267011449 RNase E inhibitor protein; Provisional; Region: PRK11191 300267011450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 300267011451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267011452 Coenzyme A binding pocket [chemical binding]; other site 300267011453 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011455 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011456 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011458 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011459 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011460 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011461 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 300267011462 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 300267011463 active site 300267011464 HIGH motif; other site 300267011465 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 300267011466 KMSKS motif; other site 300267011467 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 300267011468 tRNA binding surface [nucleotide binding]; other site 300267011469 anticodon binding site; other site 300267011470 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 300267011471 DNA polymerase III subunit chi; Validated; Region: PRK05728 300267011472 multifunctional aminopeptidase A; Provisional; Region: PRK00913 300267011473 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 300267011474 interface (dimer of trimers) [polypeptide binding]; other site 300267011475 Substrate-binding/catalytic site; other site 300267011476 Zn-binding sites [ion binding]; other site 300267011477 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 300267011478 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 300267011479 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 300267011480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267011481 Walker A motif; other site 300267011482 ATP binding site [chemical binding]; other site 300267011483 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 300267011484 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 300267011485 putative NAD(P) binding site [chemical binding]; other site 300267011486 putative substrate binding site [chemical binding]; other site 300267011487 catalytic Zn binding site [ion binding]; other site 300267011488 structural Zn binding site [ion binding]; other site 300267011489 dimer interface [polypeptide binding]; other site 300267011490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267011491 Transposase; Region: HTH_Tnp_1; cl17663 300267011492 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 300267011493 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 300267011494 Walker A/P-loop; other site 300267011495 ATP binding site [chemical binding]; other site 300267011496 Q-loop/lid; other site 300267011497 ABC transporter signature motif; other site 300267011498 Walker B; other site 300267011499 D-loop; other site 300267011500 H-loop/switch region; other site 300267011501 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267011502 ABC-ATPase subunit interface; other site 300267011503 dimer interface [polypeptide binding]; other site 300267011504 putative PBP binding regions; other site 300267011505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 300267011506 ABC-ATPase subunit interface; other site 300267011507 dimer interface [polypeptide binding]; other site 300267011508 putative PBP binding regions; other site 300267011509 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 300267011510 Secretin and TonB N terminus short domain; Region: STN; smart00965 300267011511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 300267011512 N-terminal plug; other site 300267011513 ligand-binding site [chemical binding]; other site 300267011514 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 300267011515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 300267011516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 300267011517 DNA binding residues [nucleotide binding] 300267011518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011519 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011520 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011521 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011523 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011524 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011525 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 300267011526 SdiA-regulated; Region: SdiA-regulated; cl19046 300267011527 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 300267011528 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267011529 HTH-like domain; Region: HTH_21; pfam13276 300267011530 Integrase core domain; Region: rve; pfam00665 300267011531 Integrase core domain; Region: rve_3; pfam13683 300267011532 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267011533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267011534 hypothetical protein; Provisional; Region: PRK10515 300267011535 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 300267011536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 300267011537 RNA binding surface [nucleotide binding]; other site 300267011538 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 300267011539 probable active site [active] 300267011540 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 300267011541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 300267011542 putative DNA binding site [nucleotide binding]; other site 300267011543 putative Zn2+ binding site [ion binding]; other site 300267011544 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 300267011545 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 300267011546 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 300267011547 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 300267011548 putative NAD(P) binding site [chemical binding]; other site 300267011549 catalytic Zn binding site [ion binding]; other site 300267011550 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 300267011551 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 300267011552 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 300267011553 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011555 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011556 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011557 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 300267011558 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 300267011559 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 300267011560 substrate binding pocket [chemical binding]; other site 300267011561 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 300267011562 B12 binding site [chemical binding]; other site 300267011563 cobalt ligand [ion binding]; other site 300267011564 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 300267011565 transcriptional repressor IclR; Provisional; Region: PRK11569 300267011566 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 300267011567 Bacterial transcriptional regulator; Region: IclR; pfam01614 300267011568 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011570 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011571 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011572 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 300267011573 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 300267011574 tetramer interface [polypeptide binding]; other site 300267011575 active site 300267011576 Mg2+/Mn2+ binding site [ion binding]; other site 300267011577 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 300267011578 proposed active site lysine [active] 300267011579 conserved cys residue [active] 300267011580 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011582 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011583 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 300267011585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267011586 Coenzyme A binding pocket [chemical binding]; other site 300267011587 hypothetical protein; Provisional; Region: PRK10039 300267011588 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267011589 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267011590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267011591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011592 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011593 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011594 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011596 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011597 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011598 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011599 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 300267011600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267011601 Transposase; Region: HTH_Tnp_1; pfam01527 300267011602 HTH-like domain; Region: HTH_21; pfam13276 300267011603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267011604 Integrase core domain; Region: rve; pfam00665 300267011605 Integrase core domain; Region: rve_3; pfam13683 300267011606 YsaB-like lipoprotein; Region: YsaB; pfam13983 300267011607 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 300267011608 dimer interface [polypeptide binding]; other site 300267011609 motif 1; other site 300267011610 active site 300267011611 motif 2; other site 300267011612 motif 3; other site 300267011613 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 300267011614 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 300267011615 DALR anticodon binding domain; Region: DALR_1; pfam05746 300267011616 anticodon binding site; other site 300267011617 tRNA binding surface [nucleotide binding]; other site 300267011618 small toxic polypeptide; Provisional; Region: PRK09759 300267011619 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 300267011620 DNA-binding site [nucleotide binding]; DNA binding site 300267011621 RNA-binding motif; other site 300267011622 Predicted transcriptional regulator [Transcription]; Region: COG2944 300267011623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267011624 non-specific DNA binding site [nucleotide binding]; other site 300267011625 salt bridge; other site 300267011626 sequence-specific DNA binding site [nucleotide binding]; other site 300267011627 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 300267011628 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 300267011629 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 300267011630 dimerization interface [polypeptide binding]; other site 300267011631 ligand binding site [chemical binding]; other site 300267011632 NADP binding site [chemical binding]; other site 300267011633 catalytic site [active] 300267011634 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 300267011635 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 300267011636 molybdopterin cofactor binding site [chemical binding]; other site 300267011637 substrate binding site [chemical binding]; other site 300267011638 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 300267011639 molybdopterin cofactor binding site; other site 300267011640 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 300267011641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011642 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011643 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011644 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011645 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 300267011646 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 300267011647 esterase; Provisional; Region: PRK10566 300267011648 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 300267011649 transcriptional repressor UlaR; Provisional; Region: PRK13509 300267011650 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 300267011651 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 300267011652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 300267011653 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 300267011654 active site 300267011655 P-loop; other site 300267011656 phosphorylation site [posttranslational modification] 300267011657 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 300267011658 active site 300267011659 phosphorylation site [posttranslational modification] 300267011660 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 300267011661 active site 300267011662 dimer interface [polypeptide binding]; other site 300267011663 magnesium binding site [ion binding]; other site 300267011664 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 300267011665 intersubunit interface [polypeptide binding]; other site 300267011666 active site 300267011667 Zn2+ binding site [ion binding]; other site 300267011668 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 300267011669 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 300267011670 dimer interface [polypeptide binding]; other site 300267011671 ssDNA binding site [nucleotide binding]; other site 300267011672 tetramer (dimer of dimers) interface [polypeptide binding]; other site 300267011673 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 300267011674 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 300267011675 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 300267011676 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 300267011677 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011679 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011680 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011682 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011683 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011684 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011685 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 300267011686 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 300267011687 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 300267011688 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 300267011689 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 300267011690 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 300267011691 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 300267011692 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267011693 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 300267011694 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 300267011695 Hemerythrin-like domain; Region: Hr-like; cd12108 300267011696 Fe binding site [ion binding]; other site 300267011697 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 300267011698 EamA-like transporter family; Region: EamA; pfam00892 300267011699 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 300267011700 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 300267011701 NADP binding site [chemical binding]; other site 300267011702 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 300267011703 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 300267011704 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 300267011705 active site 300267011706 metal binding site [ion binding]; metal-binding site 300267011707 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 300267011708 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011710 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011711 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011712 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 300267011713 active site 300267011714 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011716 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011717 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011718 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011720 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011721 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011722 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 300267011723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267011724 FeS/SAM binding site; other site 300267011725 elongation factor P; Validated; Region: PRK00529 300267011726 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 300267011727 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 300267011728 RNA binding site [nucleotide binding]; other site 300267011729 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 300267011730 RNA binding site [nucleotide binding]; other site 300267011731 entericidin A; Provisional; Region: PRK09810 300267011732 multidrug efflux system protein; Provisional; Region: PRK11431 300267011733 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 300267011734 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 300267011735 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 300267011736 Iron-sulfur protein interface; other site 300267011737 proximal quinone binding site [chemical binding]; other site 300267011738 C-subunit interface; other site 300267011739 distal quinone binding site; other site 300267011740 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 300267011741 D-subunit interface [polypeptide binding]; other site 300267011742 Iron-sulfur protein interface; other site 300267011743 proximal quinone binding site [chemical binding]; other site 300267011744 distal quinone binding site [chemical binding]; other site 300267011745 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 300267011746 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 300267011747 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 300267011748 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 300267011749 L-aspartate oxidase; Provisional; Region: PRK06175 300267011750 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 300267011751 poxB regulator PoxA; Provisional; Region: PRK09350 300267011752 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 300267011753 motif 1; other site 300267011754 dimer interface [polypeptide binding]; other site 300267011755 active site 300267011756 motif 2; other site 300267011757 motif 3; other site 300267011758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011759 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011760 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011761 Predicted integral membrane protein [Function unknown]; Region: COG5463 300267011762 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 300267011763 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 300267011764 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 300267011765 FAD binding site [chemical binding]; other site 300267011766 substrate binding site [chemical binding]; other site 300267011767 catalytic residues [active] 300267011768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011769 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011770 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011771 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011773 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011774 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011775 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011776 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 300267011777 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 300267011778 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 300267011779 exoribonuclease R; Provisional; Region: PRK11642 300267011780 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 300267011781 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 300267011782 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 300267011783 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 300267011784 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 300267011785 RNA binding site [nucleotide binding]; other site 300267011786 transcriptional repressor NsrR; Provisional; Region: PRK11014 300267011787 Rrf2 family protein; Region: rrf2_super; TIGR00738 300267011788 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 300267011789 GDP-binding site [chemical binding]; other site 300267011790 ACT binding site; other site 300267011791 IMP binding site; other site 300267011792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 300267011793 HflC protein; Region: hflC; TIGR01932 300267011794 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 300267011795 FtsH protease regulator HflK; Provisional; Region: PRK10930 300267011796 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 300267011797 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 300267011798 GTPase HflX; Provisional; Region: PRK11058 300267011799 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 300267011800 HflX GTPase family; Region: HflX; cd01878 300267011801 G1 box; other site 300267011802 GTP/Mg2+ binding site [chemical binding]; other site 300267011803 Switch I region; other site 300267011804 G2 box; other site 300267011805 G3 box; other site 300267011806 Switch II region; other site 300267011807 G4 box; other site 300267011808 G5 box; other site 300267011809 bacterial Hfq-like; Region: Hfq; cd01716 300267011810 hexamer interface [polypeptide binding]; other site 300267011811 Sm1 motif; other site 300267011812 RNA binding site [nucleotide binding]; other site 300267011813 Sm2 motif; other site 300267011814 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 300267011815 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 300267011816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267011817 ATP binding site [chemical binding]; other site 300267011818 Mg2+ binding site [ion binding]; other site 300267011819 G-X-G motif; other site 300267011820 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 300267011821 ATP binding site [chemical binding]; other site 300267011822 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 300267011823 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 300267011824 AMIN domain; Region: AMIN; pfam11741 300267011825 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 300267011826 active site 300267011827 metal binding site [ion binding]; metal-binding site 300267011828 ADP-binding protein; Provisional; Region: PRK10646 300267011829 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 300267011830 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011832 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011833 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011834 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011836 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011837 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011838 epoxyqueuosine reductase; Region: TIGR00276 300267011839 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 300267011840 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 300267011841 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 300267011842 catalytic site [active] 300267011843 putative active site [active] 300267011844 putative substrate binding site [chemical binding]; other site 300267011845 dimer interface [polypeptide binding]; other site 300267011846 GTPase RsgA; Reviewed; Region: PRK12288 300267011847 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 300267011848 RNA binding site [nucleotide binding]; other site 300267011849 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 300267011850 GTPase/Zn-binding domain interface [polypeptide binding]; other site 300267011851 GTP/Mg2+ binding site [chemical binding]; other site 300267011852 G4 box; other site 300267011853 G5 box; other site 300267011854 G1 box; other site 300267011855 Switch I region; other site 300267011856 G2 box; other site 300267011857 G3 box; other site 300267011858 Switch II region; other site 300267011859 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 300267011860 putative mechanosensitive channel protein; Provisional; Region: PRK10929 300267011861 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 300267011862 DNA-binding site [nucleotide binding]; DNA binding site 300267011863 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 300267011864 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 300267011865 Mechanosensitive ion channel; Region: MS_channel; pfam00924 300267011866 inner membrane transporter YjeM; Provisional; Region: PRK15238 300267011867 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011869 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011870 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011871 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011873 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011874 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011875 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 300267011876 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 300267011877 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 300267011878 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 300267011879 DsbD alpha interface [polypeptide binding]; other site 300267011880 catalytic residues [active] 300267011881 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 300267011882 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 300267011883 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 300267011884 Aspartase; Region: Aspartase; cd01357 300267011885 active sites [active] 300267011886 tetramer interface [polypeptide binding]; other site 300267011887 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 300267011888 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011890 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011891 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011892 putative transporter; Provisional; Region: PRK11021 300267011893 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 300267011894 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 300267011895 oligomerisation interface [polypeptide binding]; other site 300267011896 mobile loop; other site 300267011897 roof hairpin; other site 300267011898 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 300267011899 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 300267011900 ring oligomerisation interface [polypeptide binding]; other site 300267011901 ATP/Mg binding site [chemical binding]; other site 300267011902 stacking interactions; other site 300267011903 hinge regions; other site 300267011904 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 300267011905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011906 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011907 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011908 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011909 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 300267011910 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 300267011911 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 300267011912 Domain of unknown function DUF21; Region: DUF21; pfam01595 300267011913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 300267011914 Transporter associated domain; Region: CorC_HlyC; smart01091 300267011915 methionine sulfoxide reductase A; Provisional; Region: PRK00058 300267011916 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 300267011917 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 300267011918 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 300267011919 Surface antigen; Region: Bac_surface_Ag; pfam01103 300267011920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 300267011921 Family of unknown function (DUF490); Region: DUF490; pfam04357 300267011922 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 300267011923 putative active site pocket [active] 300267011924 dimerization interface [polypeptide binding]; other site 300267011925 putative catalytic residue [active] 300267011926 antitoxin ChpS; Provisional; Region: PRK11347 300267011927 toxin ChpB; Provisional; Region: PRK09812 300267011928 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 300267011929 dimer interface [polypeptide binding]; other site 300267011930 substrate binding site [chemical binding]; other site 300267011931 metal binding sites [ion binding]; metal-binding site 300267011932 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011934 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011935 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011936 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 300267011937 POT family; Region: PTR2; cl17359 300267011938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267011939 putative substrate translocation pore; other site 300267011940 HTH-like domain; Region: HTH_21; pfam13276 300267011941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267011942 Integrase core domain; Region: rve; pfam00665 300267011943 Integrase core domain; Region: rve_3; pfam13683 300267011944 putative transposase OrfB; Reviewed; Region: PHA02517 300267011945 HTH-like domain; Region: HTH_21; pfam13276 300267011946 Integrase core domain; Region: rve; pfam00665 300267011947 Integrase core domain; Region: rve_3; pfam13683 300267011948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011949 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011950 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011951 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267011952 Transposase, Mutator family; Region: Transposase_mut; cl19537 300267011953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 300267011954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267011955 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267011956 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267011957 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267011958 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 300267011959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267011960 active site 300267011961 phosphorylation site [posttranslational modification] 300267011962 intermolecular recognition site; other site 300267011963 dimerization interface [polypeptide binding]; other site 300267011964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 300267011965 DNA binding residues [nucleotide binding] 300267011966 dimerization interface [polypeptide binding]; other site 300267011967 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 300267011968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267011969 substrate binding pocket [chemical binding]; other site 300267011970 membrane-bound complex binding site; other site 300267011971 hinge residues; other site 300267011972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267011973 substrate binding pocket [chemical binding]; other site 300267011974 membrane-bound complex binding site; other site 300267011975 hinge residues; other site 300267011976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 300267011977 dimer interface [polypeptide binding]; other site 300267011978 phosphorylation site [posttranslational modification] 300267011979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 300267011980 ATP binding site [chemical binding]; other site 300267011981 Mg2+ binding site [ion binding]; other site 300267011982 G-X-G motif; other site 300267011983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267011984 active site 300267011985 phosphorylation site [posttranslational modification] 300267011986 intermolecular recognition site; other site 300267011987 dimerization interface [polypeptide binding]; other site 300267011988 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 300267011989 putative binding surface; other site 300267011990 active site 300267011991 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 300267011992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 300267011993 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 300267011994 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 300267011995 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 300267011996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 300267011997 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 300267011998 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 300267011999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 300267012000 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 300267012001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012002 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012003 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012004 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012005 HTH-like domain; Region: HTH_21; pfam13276 300267012006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012007 Integrase core domain; Region: rve; pfam00665 300267012008 Integrase core domain; Region: rve_3; pfam13683 300267012009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012010 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012011 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012012 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 300267012014 TPR motif; other site 300267012015 binding surface 300267012016 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012018 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012019 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012020 HTH-like domain; Region: HTH_21; pfam13276 300267012021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012022 Integrase core domain; Region: rve; pfam00665 300267012023 Integrase core domain; Region: rve_3; pfam13683 300267012024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012025 Transposase; Region: HTH_Tnp_1; pfam01527 300267012026 Methyltransferase domain; Region: Methyltransf_27; pfam13708 300267012027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012028 Transposase; Region: HTH_Tnp_1; cl17663 300267012029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012030 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012031 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012032 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012033 EamA-like transporter family; Region: EamA; pfam00892 300267012034 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 300267012035 EamA-like transporter family; Region: EamA; pfam00892 300267012036 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 300267012037 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012039 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012040 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012041 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 300267012042 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 300267012043 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 300267012044 Sulfate transporter family; Region: Sulfate_transp; cl19250 300267012045 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 300267012046 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 300267012047 DNA binding residues [nucleotide binding] 300267012048 dimer interface [polypeptide binding]; other site 300267012049 [2Fe-2S] cluster binding site [ion binding]; other site 300267012050 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 300267012051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267012052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012053 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012054 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012055 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012056 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 300267012057 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 300267012058 dimer interface [polypeptide binding]; other site 300267012059 ssDNA binding site [nucleotide binding]; other site 300267012060 tetramer (dimer of dimers) interface [polypeptide binding]; other site 300267012061 putative single-stranded DNA-binding protein; Region: PHA01740 300267012062 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 300267012063 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 300267012064 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 300267012065 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 300267012066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 300267012067 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 300267012068 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012070 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012071 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012073 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012074 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012075 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 300267012076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267012077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267012078 homodimer interface [polypeptide binding]; other site 300267012079 catalytic residue [active] 300267012080 alanine racemase; Reviewed; Region: alr; PRK00053 300267012081 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 300267012082 active site 300267012083 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 300267012084 substrate binding site [chemical binding]; other site 300267012085 catalytic residues [active] 300267012086 dimer interface [polypeptide binding]; other site 300267012087 replicative DNA helicase; Provisional; Region: PRK08006 300267012088 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 300267012089 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 300267012090 Walker A motif; other site 300267012091 ATP binding site [chemical binding]; other site 300267012092 Walker B motif; other site 300267012093 DNA binding loops [nucleotide binding] 300267012094 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 300267012095 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 300267012096 NADP binding site [chemical binding]; other site 300267012097 dimer interface [polypeptide binding]; other site 300267012098 phage shock protein G; Reviewed; Region: pspG; PRK09459 300267012099 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 300267012100 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 300267012101 FMN binding site [chemical binding]; other site 300267012102 active site 300267012103 catalytic residues [active] 300267012104 substrate binding site [chemical binding]; other site 300267012105 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 300267012106 metal binding site 2 [ion binding]; metal-binding site 300267012107 putative DNA binding helix; other site 300267012108 metal binding site 1 [ion binding]; metal-binding site 300267012109 dimer interface [polypeptide binding]; other site 300267012110 structural Zn2+ binding site [ion binding]; other site 300267012111 hypothetical protein; Provisional; Region: PRK10428 300267012112 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 300267012113 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 300267012114 LexA repressor; Validated; Region: PRK00215 300267012115 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 300267012116 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 300267012117 Catalytic site [active] 300267012118 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 300267012119 putative active site [active] 300267012120 trimer interface [polypeptide binding]; other site 300267012121 putative active site [active] 300267012122 Zn binding site [ion binding]; other site 300267012123 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 300267012124 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 300267012125 putative acyl-acceptor binding pocket; other site 300267012126 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 300267012127 putative active site [active] 300267012128 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 300267012129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012130 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012131 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012132 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012134 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012135 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012136 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 300267012138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 300267012139 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 300267012140 putative effector binding pocket; other site 300267012141 putative dimerization interface [polypeptide binding]; other site 300267012142 inner membrane protein YhjD; Region: TIGR00766 300267012143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267012144 metabolite-proton symporter; Region: 2A0106; TIGR00883 300267012145 putative substrate translocation pore; other site 300267012146 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 300267012147 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 300267012148 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 300267012149 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 300267012150 substrate binding site [chemical binding]; other site 300267012151 ATP binding site [chemical binding]; other site 300267012152 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 300267012153 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 300267012154 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 300267012155 putative diguanylate cyclase; Provisional; Region: PRK13561 300267012156 HAMP domain; Region: HAMP; pfam00672 300267012157 diguanylate cyclase; Region: GGDEF; smart00267 300267012158 metal binding site [ion binding]; metal-binding site 300267012159 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 300267012160 cellulose synthase regulator protein; Provisional; Region: PRK11114 300267012161 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 300267012162 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 300267012163 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 300267012164 DXD motif; other site 300267012165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 300267012166 PilZ domain; Region: PilZ; pfam07238 300267012167 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 300267012168 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012170 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012171 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012172 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012173 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 300267012174 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 300267012175 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 300267012176 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 300267012177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267012178 Walker A/P-loop; other site 300267012179 ATP binding site [chemical binding]; other site 300267012180 Q-loop/lid; other site 300267012181 ABC transporter signature motif; other site 300267012182 Walker B; other site 300267012183 D-loop; other site 300267012184 H-loop/switch region; other site 300267012185 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267012186 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 300267012187 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 300267012188 Walker A/P-loop; other site 300267012189 ATP binding site [chemical binding]; other site 300267012190 Q-loop/lid; other site 300267012191 ABC transporter signature motif; other site 300267012192 Walker B; other site 300267012193 D-loop; other site 300267012194 H-loop/switch region; other site 300267012195 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 300267012196 dipeptide transporter; Provisional; Region: PRK10913 300267012197 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 300267012198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267012199 dimer interface [polypeptide binding]; other site 300267012200 conserved gate region; other site 300267012201 putative PBP binding loops; other site 300267012202 ABC-ATPase subunit interface; other site 300267012203 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 300267012204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 300267012205 dimer interface [polypeptide binding]; other site 300267012206 conserved gate region; other site 300267012207 putative PBP binding loops; other site 300267012208 ABC-ATPase subunit interface; other site 300267012209 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 300267012210 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 300267012211 peptide binding site [polypeptide binding]; other site 300267012212 PapC N-terminal domain; Region: PapC_N; pfam13954 300267012213 Outer membrane usher protein; Region: Usher; pfam00577 300267012214 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267012215 HTH-like domain; Region: HTH_21; pfam13276 300267012216 Integrase core domain; Region: rve; pfam00665 300267012217 Integrase core domain; Region: rve_3; pfam13683 300267012218 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267012219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012220 HTH-like domain; Region: HTH_21; pfam13276 300267012221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012222 Integrase core domain; Region: rve; pfam00665 300267012223 Integrase core domain; Region: rve_3; pfam13683 300267012224 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012226 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012227 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012228 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 300267012229 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012231 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012232 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012233 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267012234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012235 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267012236 HTH-like domain; Region: HTH_21; pfam13276 300267012237 Integrase core domain; Region: rve; pfam00665 300267012238 Integrase core domain; Region: rve_3; pfam13683 300267012239 HTH-like domain; Region: HTH_21; pfam13276 300267012240 Integrase core domain; Region: rve; pfam00665 300267012241 Integrase core domain; Region: rve_3; pfam13683 300267012242 Antirestriction protein; Region: Antirestrict; pfam03230 300267012243 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 300267012244 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 300267012245 MPN+ (JAMM) motif; other site 300267012246 Zinc-binding site [ion binding]; other site 300267012247 Protein of unknown function (DUF987); Region: DUF987; pfam06174 300267012248 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 300267012249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012250 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012251 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012252 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 300267012253 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 300267012254 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 300267012255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 300267012256 putative substrate translocation pore; other site 300267012257 Uncharacterized conserved protein [Function unknown]; Region: COG5464 300267012258 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 300267012259 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 300267012260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 300267012261 DNA-binding site [nucleotide binding]; DNA binding site 300267012262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 300267012263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 300267012264 homodimer interface [polypeptide binding]; other site 300267012265 catalytic residue [active] 300267012266 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 300267012267 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012269 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012270 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012271 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 300267012272 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 300267012273 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 300267012274 Uncharacterized small protein [Function unknown]; Region: COG2879 300267012275 carbon starvation protein A; Provisional; Region: PRK15015 300267012276 Carbon starvation protein CstA; Region: CstA; pfam02554 300267012277 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 300267012278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012279 Transposase; Region: HTH_Tnp_1; pfam01527 300267012280 phosphoglycerol transferase I; Provisional; Region: PRK03776 300267012281 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 300267012282 hypothetical protein; Provisional; Region: PRK11667 300267012283 DNA replication protein DnaC; Validated; Region: PRK07952 300267012284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267012285 Walker A motif; other site 300267012286 ATP binding site [chemical binding]; other site 300267012287 Walker B motif; other site 300267012288 primosomal protein DnaI; Provisional; Region: PRK02854 300267012289 hypothetical protein; Provisional; Region: PRK09917 300267012290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012291 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012292 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012293 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012294 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012296 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012297 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012299 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012300 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012301 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012302 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 300267012303 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 300267012304 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 300267012305 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 300267012306 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 300267012307 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 300267012308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 300267012309 S-adenosylmethionine binding site [chemical binding]; other site 300267012310 DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050 300267012311 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 300267012312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 300267012313 Coenzyme A binding pocket [chemical binding]; other site 300267012314 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 300267012315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267012316 motif II; other site 300267012317 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 300267012318 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 300267012319 G1 box; other site 300267012320 putative GEF interaction site [polypeptide binding]; other site 300267012321 GTP/Mg2+ binding site [chemical binding]; other site 300267012322 Switch I region; other site 300267012323 G2 box; other site 300267012324 G3 box; other site 300267012325 Switch II region; other site 300267012326 G4 box; other site 300267012327 G5 box; other site 300267012328 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 300267012329 Elongation Factor G, domain II; Region: EFG_II; pfam14492 300267012330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012331 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012332 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012333 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012334 periplasmic protein; Provisional; Region: PRK10568 300267012335 BON domain; Region: BON; pfam04972 300267012336 BON domain; Region: BON; pfam04972 300267012337 Small integral membrane protein [Function unknown]; Region: COG5487 300267012338 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 300267012339 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 300267012340 active site 300267012341 nucleophile elbow; other site 300267012342 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 300267012343 active site 300267012344 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 300267012345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 300267012346 FeS/SAM binding site; other site 300267012347 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 300267012348 hypothetical protein; Provisional; Region: PRK10977 300267012349 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 300267012350 intersubunit interface [polypeptide binding]; other site 300267012351 active site 300267012352 catalytic residue [active] 300267012353 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 300267012354 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 300267012355 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 300267012356 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 300267012357 phosphopentomutase; Provisional; Region: PRK05362 300267012358 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 300267012359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012360 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012361 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012362 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012363 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 300267012364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267012365 non-specific DNA binding site [nucleotide binding]; other site 300267012366 salt bridge; other site 300267012367 sequence-specific DNA binding site [nucleotide binding]; other site 300267012368 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 300267012369 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 300267012370 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 300267012371 hypothetical protein; Provisional; Region: PRK11246 300267012372 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 300267012373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 300267012374 motif II; other site 300267012375 DNA repair protein RadA; Region: sms; TIGR00416 300267012376 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 300267012377 Walker A motif/ATP binding site; other site 300267012378 ATP binding site [chemical binding]; other site 300267012379 Walker B motif; other site 300267012380 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 300267012381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 300267012382 non-specific DNA binding site [nucleotide binding]; other site 300267012383 salt bridge; other site 300267012384 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 300267012385 sequence-specific DNA binding site [nucleotide binding]; other site 300267012386 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 300267012387 active site 300267012388 (T/H)XGH motif; other site 300267012389 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 300267012390 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 300267012391 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267012392 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 300267012393 ABC transporter; Region: ABC_tran_2; pfam12848 300267012394 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 300267012395 lytic murein transglycosylase; Provisional; Region: PRK11619 300267012396 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 300267012397 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 300267012398 N-acetyl-D-glucosamine binding site [chemical binding]; other site 300267012399 catalytic residue [active] 300267012400 Trp operon repressor [Transcription]; Region: TrpR; COG2973 300267012401 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 300267012402 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 300267012403 catalytic core [active] 300267012404 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 300267012405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267012406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267012407 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 300267012408 hypothetical protein; Provisional; Region: PRK10756 300267012409 DNA-binding response regulator CreB; Provisional; Region: PRK11083 300267012410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267012411 active site 300267012412 phosphorylation site [posttranslational modification] 300267012413 intermolecular recognition site; other site 300267012414 dimerization interface [polypeptide binding]; other site 300267012415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267012416 DNA binding site [nucleotide binding] 300267012417 two-component response regulator; Provisional; Region: PRK11173 300267012418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 300267012419 active site 300267012420 phosphorylation site [posttranslational modification] 300267012421 intermolecular recognition site; other site 300267012422 dimerization interface [polypeptide binding]; other site 300267012423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 300267012424 DNA binding site [nucleotide binding] 300267012425 putative RNA methyltransferase; Provisional; Region: PRK10433 300267012426 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 300267012427 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267012428 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 300267012429 active site 300267012430 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 300267012431 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 300267012433 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 300267012434 HTH-like domain; Region: HTH_21; pfam13276 300267012435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012436 Transposase; Region: HTH_Tnp_1; pfam01527 300267012437 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 300267012438 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267012439 HTH-like domain; Region: HTH_21; pfam13276 300267012440 Integrase core domain; Region: rve; pfam00665 300267012441 Integrase core domain; Region: rve_3; pfam13683 300267012442 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267012443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012444 type III effector phosphothreonine lyase; Provisional; Region: PRK15245 300267012445 Transposase; Region: DDE_Tnp_ISL3; pfam01610 300267012446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 300267012447 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 300267012448 Putative transposase; Region: Y2_Tnp; pfam04986 300267012449 Transposase; Region: HTH_Tnp_1; pfam01527 300267012450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012451 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 300267012452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 300267012453 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 300267012454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 300267012455 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 300267012456 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 300267012457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 300267012458 Transposase, Mutator family; Region: Transposase_mut; cl19537 300267012459 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 300267012460 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 300267012461 Transposase; Region: HTH_Tnp_1; cl17663 300267012462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012463 putative transposase OrfB; Reviewed; Region: PHA02517 300267012464 HTH-like domain; Region: HTH_21; pfam13276 300267012465 Integrase core domain; Region: rve; pfam00665 300267012466 Integrase core domain; Region: rve_2; pfam13333 300267012467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012468 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012469 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 300267012471 Integrase core domain; Region: rve; pfam00665 300267012472 transposase/IS protein; Provisional; Region: PRK09183 300267012473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267012474 Walker A motif; other site 300267012475 ATP binding site [chemical binding]; other site 300267012476 Walker B motif; other site 300267012477 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 300267012478 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 300267012479 Magnesium ion binding site [ion binding]; other site 300267012480 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 300267012481 ParB-like nuclease domain; Region: ParB; smart00470 300267012482 ParB family; Region: ParB; pfam08775 300267012483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267012484 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267012485 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 300267012486 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 300267012487 putative active site [active] 300267012488 putative NTP binding site [chemical binding]; other site 300267012489 putative nucleic acid binding site [nucleotide binding]; other site 300267012490 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 300267012491 Integrase core domain; Region: rve; pfam00665 300267012492 Integrase core domain; Region: rve_3; pfam13683 300267012493 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267012494 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 300267012495 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267012496 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267012497 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 300267012498 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267012499 Integrase core domain; Region: rve; pfam00665 300267012500 Integrase core domain; Region: rve_3; pfam13683 300267012501 HTH-like domain; Region: HTH_21; pfam13276 300267012502 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 300267012504 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 300267012505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 300267012506 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 300267012507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 300267012508 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 300267012509 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267012510 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267012511 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012513 Transposase; Region: HTH_Tnp_1; pfam01527 300267012514 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012516 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012517 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012518 Integrase core domain; Region: rve; pfam00665 300267012519 Integrase core domain; Region: rve_3; pfam13683 300267012520 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267012521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267012522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267012523 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267012524 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 300267012525 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 300267012526 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 300267012527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 300267012528 membrane-bound complex binding site; other site 300267012529 hinge residues; other site 300267012530 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012532 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012533 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 300267012535 Transposase, Mutator family; Region: Transposase_mut; cl19537 300267012536 Transposase DNA-binding; Region: Tnp_DNA_bind; pfam14706 300267012537 putative transposase OrfB; Reviewed; Region: PHA02517 300267012538 HTH-like domain; Region: HTH_21; pfam13276 300267012539 Integrase core domain; Region: rve; pfam00665 300267012540 Integrase core domain; Region: rve_3; pfam13683 300267012541 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 300267012542 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 300267012543 active site 300267012544 metal binding site [ion binding]; metal-binding site 300267012545 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 300267012546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012547 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012548 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012549 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012550 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 300267012551 active site 300267012552 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 300267012553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 300267012554 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 300267012555 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 300267012556 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267012557 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 300267012558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 300267012559 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 300267012560 RelB antitoxin; Region: RelB; cl01171 300267012561 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 300267012562 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 300267012563 Mg binding site [ion binding]; other site 300267012564 nucleotide binding site [chemical binding]; other site 300267012565 putative protofilament interface [polypeptide binding]; other site 300267012566 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 300267012567 HTH-like domain; Region: HTH_21; pfam13276 300267012568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012569 Integrase core domain; Region: rve; pfam00665 300267012570 Integrase core domain; Region: rve_3; pfam13683 300267012571 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012572 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012573 Transposase; Region: HTH_Tnp_1; pfam01527 300267012574 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267012575 Transposase; Region: HTH_Tnp_1; cl17663 300267012576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012577 Papain fold toxin 1; Region: Tox-PL; pfam15644 300267012578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012579 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012580 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 300267012582 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 300267012583 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 300267012584 Predicted transcriptional regulator [Transcription]; Region: COG3905 300267012585 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 300267012586 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 300267012587 StbA protein; Region: StbA; cl19281 300267012588 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 300267012589 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 300267012590 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 300267012591 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012593 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012594 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012595 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 300267012596 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 300267012597 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012598 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 300267012599 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 300267012600 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 300267012601 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267012602 Predicted transcriptional regulator [Transcription]; Region: COG3905 300267012603 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 300267012604 active site 300267012605 ATP binding site [chemical binding]; other site 300267012606 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 300267012607 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267012608 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267012609 putative transposase OrfB; Reviewed; Region: PHA02517 300267012610 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 300267012611 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 300267012612 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 300267012613 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 300267012614 putative active site [active] 300267012615 putative metal binding site [ion binding]; other site 300267012616 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 300267012617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 300267012618 Protein of unknown function (DUF535); Region: DUF535; pfam04393 300267012619 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 300267012620 putative acyl-acceptor binding pocket; other site 300267012621 Transposase; Region: HTH_Tnp_1; pfam01527 300267012622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012623 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 300267012624 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 300267012625 putative active site [active] 300267012626 putative NTP binding site [chemical binding]; other site 300267012627 putative nucleic acid binding site [nucleotide binding]; other site 300267012628 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 300267012629 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 300267012630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 300267012631 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 300267012632 HTH-like domain; Region: HTH_21; pfam13276 300267012633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012634 Integrase core domain; Region: rve; pfam00665 300267012635 Integrase core domain; Region: rve_3; pfam13683 300267012636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012637 Transposase; Region: HTH_Tnp_1; pfam01527 300267012638 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 300267012639 multimer interface [polypeptide binding]; other site 300267012640 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 300267012641 Walker A motif; other site 300267012642 ATP binding site [chemical binding]; other site 300267012643 Walker B motif; other site 300267012644 conjugal transfer protein TraD; Provisional; Region: PRK13700 300267012645 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 300267012646 TrwC relaxase; Region: TrwC; cl19905 300267012647 TrwC relaxase; Region: TrwC; cl19905 300267012648 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 300267012649 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 300267012650 AAA domain; Region: AAA_30; pfam13604 300267012651 DNA helicase TraI; Region: TraI; pfam07057 300267012652 DNA helicase TraI; Region: TraI; pfam07057 300267012653 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 300267012654 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 300267012655 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 300267012656 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 300267012657 putative kissing complex interaction region; other site 300267012658 putative RNA binding sites [nucleotide binding]; other site 300267012659 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 300267012660 Catalytic site; other site 300267012661 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012662 Staphylococcal nuclease homologue; Region: SNase; pfam00565 300267012663 Haemolysin expression modulating protein; Region: HHA; cl11501 300267012664 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012666 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012667 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012668 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 300267012669 replication protein; Provisional; Region: PRK13702 300267012670 replication protein; Provisional; Region: PRK13750 300267012671 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 300267012672 Putative transposase; Region: Y2_Tnp; pfam04986 300267012673 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 300267012674 HTH-like domain; Region: HTH_21; pfam13276 300267012675 Integrase core domain; Region: rve; pfam00665 300267012676 Integrase core domain; Region: rve_3; pfam13683 300267012677 putative transposase OrfB; Reviewed; Region: PHA02517 300267012678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012679 Transposase; Region: HTH_Tnp_1; pfam01527 300267012680 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 300267012681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 300267012682 transposase/IS protein; Provisional; Region: PRK09183 300267012683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 300267012684 Walker A motif; other site 300267012685 ATP binding site [chemical binding]; other site 300267012686 Walker B motif; other site 300267012687 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 300267012688 Putative transposase; Region: Y2_Tnp; pfam04986 300267012689 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 300267012690 Homeodomain-like domain; Region: HTH_23; pfam13384 300267012691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012692 Transposase; Region: HTH_Tnp_1; pfam01527 300267012693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012694 Transposase; Region: HTH_Tnp_1; cl17663 300267012695 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 300267012696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012697 Transposase; Region: HTH_Tnp_1; pfam01527 300267012698 HTH-like domain; Region: HTH_21; pfam13276 300267012699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012700 Integrase core domain; Region: rve; pfam00665 300267012701 Integrase core domain; Region: rve_3; pfam13683 300267012702 HTH-like domain; Region: HTH_21; pfam13276 300267012703 Integrase core domain; Region: rve; pfam00665 300267012704 Integrase core domain; Region: rve_3; cl15866 300267012705 Transposase Tn5 dimerization domain; Region: Dimer_Tnp_Tn5; pfam02281 300267012706 Transposase; Region: DEDD_Tnp_IS110; pfam01548 300267012707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 300267012708 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 300267012709 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 300267012710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 300267012711 Integrase core domain; Region: rve; pfam00665 300267012712 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 300267012713 ParB-like nuclease domain; Region: ParB; smart00470 300267012714 ParB family; Region: ParB; pfam08775 300267012715 Phosphopantetheine attachment site; Region: PP-binding; cl09936 300267012716 Salmonella invasion protein A; Region: SipA; cl19731 300267012717 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 300267012718 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 300267012719 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 300267012720 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 300267012721 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 300267012722 Tetratricopeptide repeat; Region: TPR_3; pfam07720 300267012723 Tetratricopeptide repeat; Region: TPR_3; pfam07720 300267012724 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 300267012725 chaperone protein SicP; Provisional; Region: PRK15329 300267012726 Enterobacterial virulence protein IpgD; Region: IpgD; cl19613 300267012727 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 300267012728 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 300267012729 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 300267012730 N-acetyl-D-glucosamine binding site [chemical binding]; other site 300267012731 catalytic residue [active] 300267012732 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; cl12363 300267012733 Type III secretion needle MxiH like; Region: MxiH; cl09641 300267012734 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 300267012735 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 300267012736 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; pfam09482 300267012737 invasion protein OrgB; Provisional; Region: PRK15322 300267012738 Pilot protein MxiM; Region: MxiM; pfam11441 300267012739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 300267012740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 300267012741 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 300267012742 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 300267012743 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 300267012744 type III secretion system regulator InvE; Provisional; Region: PRK15338 300267012745 HrpJ-like domain; Region: HrpJ; pfam07201 300267012746 type III secretion system protein InvA; Provisional; Region: PRK15337 300267012747 Invasion protein B family; Region: Invas_SpaK; pfam03519 300267012748 ATP synthase SpaL; Validated; Region: PRK08149 300267012749 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 300267012750 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 300267012751 Walker A motif; other site 300267012752 ATP binding site [chemical binding]; other site 300267012753 Walker B motif; other site 300267012754 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 300267012755 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 300267012756 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 300267012757 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 300267012758 type III secretion system protein SpaS; Validated; Region: PRK08156 300267012759 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 300267012760 HTH-like domain; Region: HTH_21; pfam13276 300267012761 Integrase core domain; Region: rve; pfam00665 300267012762 HTH-like domain; Region: HTH_21; pfam13276 300267012763 Transposase; Region: HTH_Tnp_1; cl17663 300267012764 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 300267012765 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 300267012766 Transposase; Region: DDE_Tnp_ISL3; pfam01610 300267012767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 300267012768 Integrase core domain; Region: rve; pfam00665 300267012769 Integrase core domain; Region: rve_3; pfam13683 300267012770 Putative transposase; Region: Y2_Tnp; pfam04986 300267012771 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 300267012772 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 300267012773 NTP binding site [chemical binding]; other site 300267012774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012775 putative transposase OrfB; Reviewed; Region: PHA02517 300267012776 putative transposase OrfB; Reviewed; Region: PHA02517 300267012777 EspG protein; Region: EspG; pfam06872 300267012778 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 300267012779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012780 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012781 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012782 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 300267012783 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 300267012784 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 300267012785 Autotransporter beta-domain; Region: Autotransporter; pfam03797 300267012786 IS2 transposase TnpB; Reviewed; Region: PRK09409 300267012787 HTH-like domain; Region: HTH_21; pfam13276 300267012788 Integrase core domain; Region: rve; pfam00665 300267012789 Integrase core domain; Region: rve_3; pfam13683 300267012790 IS2 repressor TnpA; Reviewed; Region: PRK09413 300267012791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 300267012792 Integrase core domain; Region: rve; pfam00665 300267012793 Integrase core domain; Region: rve_3; pfam13683 300267012794 replication protein; Provisional; Region: PRK13702 300267012795 replication protein; Provisional; Region: PRK13750 300267012796 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 300267012797 Integrase core domain; Region: rve_3; cl15866 300267012798 Omptin family; Region: Omptin; pfam01278 300267012799 Initiator Replication protein; Region: Rep_3; pfam01051 300267012800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 300267012801 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 300267012802 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 300267012803 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 300267012804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 300267012805 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 300267012806 putative ADP-binding pocket [chemical binding]; other site 300267012807 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 300267012808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 300267012809 active site 300267012810 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 300267012811 Putative transposase; Region: Y2_Tnp; pfam04986