-- dump date   	20140620_065155
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
591020000001	Integrase core domain; Region: rve_3; pfam13683
591020000002	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
591020000003	active site
591020000004	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591020000005	Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128
591020000006	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020000007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000008	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020000009	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000010	HTH-like domain; Region: HTH_21; pfam13276
591020000011	putative transposase OrfB; Reviewed; Region: PHA02517
591020000012	Integrase core domain; Region: rve; pfam00665
591020000013	Integrase core domain; Region: rve_3; pfam13683
591020000014	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000015	Transposase; Region: HTH_Tnp_1; pfam01527
591020000016	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
591020000017	Salmonella virulence-associated 28kDa protein; Region: VRP3; pfam03536
591020000018	Transposase; Region: DDE_Tnp_ISL3; pfam01610
591020000019	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
591020000020	Transposase; Region: DDE_Tnp_ISL3; pfam01610
591020000021	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020000022	Putative transposase; Region: Y2_Tnp; pfam04986
591020000023	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020000024	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020000025	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020000026	Transposase; Region: HTH_Tnp_1; pfam01527
591020000027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000028	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020000029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000030	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020000031	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000032	Integrase core domain; Region: rve_3; cl15866
591020000033	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
591020000034	IpaB/EvcA family; Region: IpaB_EvcA; pfam03278
591020000035	Integrase core domain; Region: rve; pfam00665
591020000036	Integrase core domain; Region: rve_2; pfam13333
591020000037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
591020000038	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
591020000039	Helix-turn-helix domain; Region: HTH_38; pfam13936
591020000040	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
591020000041	Integrase core domain; Region: rve; pfam00665
591020000042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
591020000043	transposase/IS protein; Provisional; Region: PRK09183
591020000044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020000045	Walker A motif; other site
591020000046	ATP binding site [chemical binding]; other site
591020000047	Walker B motif; other site
591020000048	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000049	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
591020000050	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
591020000051	Magnesium ion binding site [ion binding]; other site
591020000052	ParB-like nuclease domain; Region: ParB; smart00470
591020000053	ParB family; Region: ParB; pfam08775
591020000054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
591020000055	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020000056	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020000057	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
591020000058	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
591020000059	putative active site [active]
591020000060	putative NTP binding site [chemical binding]; other site
591020000061	putative nucleic acid binding site [nucleotide binding]; other site
591020000062	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
591020000063	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000064	HTH-like domain; Region: HTH_21; pfam13276
591020000065	Integrase core domain; Region: rve; pfam00665
591020000066	Integrase core domain; Region: rve_3; pfam13683
591020000067	Integrase core domain; Region: rve; pfam00665
591020000068	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020000069	Putative transposase; Region: Y2_Tnp; pfam04986
591020000070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000071	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020000072	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020000073	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591020000074	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020000075	Integrase core domain; Region: rve_3; cl15866
591020000076	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000077	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020000078	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
591020000079	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020000080	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
591020000081	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020000082	HTH-like domain; Region: HTH_21; pfam13276
591020000083	Integrase core domain; Region: rve; pfam00665
591020000084	Integrase core domain; Region: rve_3; pfam13683
591020000085	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000086	Transposase; Region: HTH_Tnp_1; pfam01527
591020000087	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591020000088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
591020000089	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020000090	Putative transposase; Region: Y2_Tnp; pfam04986
591020000091	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
591020000092	Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128
591020000093	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000094	HTH-like domain; Region: HTH_21; pfam13276
591020000095	Integrase core domain; Region: rve; pfam00665
591020000096	Integrase core domain; Region: rve_3; pfam13683
591020000097	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000098	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020000099	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020000100	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
591020000101	Walker A motif; other site
591020000102	ATP binding site [chemical binding]; other site
591020000103	Walker B motif; other site
591020000104	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
591020000105	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
591020000106	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
591020000107	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020000108	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591020000109	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020000110	Putative transposase; Region: Y2_Tnp; pfam04986
591020000111	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020000112	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
591020000113	Homeodomain-like domain; Region: HTH_23; pfam13384
591020000114	Winged helix-turn helix; Region: HTH_29; pfam13551
591020000115	Homeodomain-like domain; Region: HTH_32; pfam13565
591020000116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
591020000117	DDE superfamily endonuclease; Region: DDE_3; pfam13358
591020000118	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000119	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000120	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000121	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020000122	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591020000123	Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364
591020000124	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020000125	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
591020000126	HTH-like domain; Region: HTH_21; pfam13276
591020000127	Integrase core domain; Region: rve; pfam00665
591020000128	Integrase core domain; Region: rve_3; pfam13683
591020000129	S-type Pyocin; Region: Pyocin_S; pfam06958
591020000130	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
591020000131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020000132	putative substrate translocation pore; other site
591020000133	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
591020000134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591020000135	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000136	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020000137	HTH-like domain; Region: HTH_21; pfam13276
591020000138	Integrase core domain; Region: rve; pfam00665
591020000139	Integrase core domain; Region: rve_3; pfam13683
591020000140	transposase/IS protein; Provisional; Region: PRK09183
591020000141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020000142	Walker A motif; other site
591020000143	ATP binding site [chemical binding]; other site
591020000144	Walker B motif; other site
591020000145	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020000146	Putative transposase; Region: Y2_Tnp; pfam04986
591020000147	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
591020000148	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
591020000149	membrane-bound complex binding site; other site
591020000150	hinge residues; other site
591020000151	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
591020000152	Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128
591020000153	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020000154	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020000155	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
591020000156	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591020000157	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020000158	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020000159	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000160	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020000161	HTH-like domain; Region: HTH_21; pfam13276
591020000162	Integrase core domain; Region: rve; pfam00665
591020000163	Integrase core domain; Region: rve_3; pfam13683
591020000164	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020000165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
591020000166	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020000167	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
591020000168	ParB-like nuclease domain; Region: ParB; smart00470
591020000169	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
591020000170	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020000171	HTH-like domain; Region: HTH_21; pfam13276
591020000172	Integrase core domain; Region: rve; pfam00665
591020000173	Integrase core domain; Region: rve_3; pfam13683
591020000174	Transposase; Region: HTH_Tnp_1; cl17663
591020000175	putative transposase OrfB; Reviewed; Region: PHA02517
591020000176	Integrase core domain; Region: rve; pfam00665
591020000177	Integrase core domain; Region: rve_3; pfam13683
591020000178	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000179	Transposase; Region: HTH_Tnp_1; pfam01527
591020000180	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591020000181	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
591020000182	Coenzyme A binding pocket [chemical binding]; other site
591020000183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
591020000184	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020000185	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000186	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020000187	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000188	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020000189	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020000190	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000191	Homeodomain-like domain; Region: HTH_23; pfam13384
591020000192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000193	Transposase; Region: HTH_Tnp_1; pfam01527
591020000194	Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128
591020000195	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000196	Transposase; Region: HTH_Tnp_1; pfam01527
591020000197	HTH-like domain; Region: HTH_21; pfam13276
591020000198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
591020000199	Integrase core domain; Region: rve; pfam00665
591020000200	Integrase core domain; Region: rve_3; pfam13683
591020000201	HTH-like domain; Region: HTH_21; pfam13276
591020000202	Integrase core domain; Region: rve; pfam00665
591020000203	Integrase core domain; Region: rve_2; pfam13333
591020000204	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020000205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
591020000206	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020000207	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
591020000208	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
591020000209	DNA-binding interface [nucleotide binding]; DNA binding site
591020000210	Integrase core domain; Region: rve; pfam00665
591020000211	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
591020000212	ParB-like nuclease domain; Region: ParB; smart00470
591020000213	ParB family; Region: ParB; pfam08775
591020000214	acyl carrier protein; Provisional; Region: acpP; PRK00982
591020000215	Salmonella invasion protein A; Region: SipA; pfam09052
591020000216	Invasion plasmid antigen IpaD; Region: IpaD; cl05827
591020000217	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
591020000218	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
591020000219	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
591020000220	Tetratricopeptide repeat; Region: TPR_3; pfam07720
591020000221	Tetratricopeptide repeat; Region: TPR_3; pfam07720
591020000222	IpaB/EvcA family; Region: IpaB_EvcA; pfam03278
591020000223	chaperone protein SicP; Provisional; Region: PRK15329
591020000224	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
591020000225	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
591020000226	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
591020000227	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
591020000228	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020000229	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020000230	catalytic residue [active]
591020000231	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
591020000232	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363
591020000233	Type III secretion needle MxiH like; Region: MxiH; cl09641
591020000234	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
591020000235	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
591020000236	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
591020000237	invasion protein OrgA; Provisional; Region: PRK15323
591020000238	invasion protein OrgB; Provisional; Region: PRK15322
591020000239	Pilot protein MxiM; Region: MxiM; pfam11441
591020000240	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591020000241	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
591020000242	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591020000243	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
591020000244	type III secretion system regulator InvE; Provisional; Region: PRK15338
591020000245	HrpJ-like domain; Region: HrpJ; pfam07201
591020000246	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
591020000247	type III secretion system protein InvA; Provisional; Region: PRK15337
591020000248	Invasion protein B family; Region: Invas_SpaK; pfam03519
591020000249	ATP synthase SpaL; Validated; Region: PRK08149
591020000250	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591020000251	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
591020000252	Walker A motif; other site
591020000253	ATP binding site [chemical binding]; other site
591020000254	Walker B motif; other site
591020000255	type III secretion system protein SpaO; Validated; Region: PRK08158
591020000256	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
591020000257	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
591020000258	type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403
591020000259	type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401
591020000260	type III secretion system protein SpaS; Validated; Region: PRK08156
591020000261	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
591020000262	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
591020000263	HTH-like domain; Region: HTH_21; pfam13276
591020000264	Integrase core domain; Region: rve; pfam00665
591020000265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000266	Transposase; Region: HTH_Tnp_1; pfam01527
591020000267	Integrase core domain; Region: rve_3; pfam13683
591020000268	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020000269	Putative transposase; Region: Y2_Tnp; pfam04986
591020000270	HTH-like domain; Region: HTH_21; pfam13276
591020000271	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020000272	Transposase; Region: DDE_Tnp_ISL3; pfam01610
591020000273	HTH-like domain; Region: HTH_21; pfam13276
591020000274	Integrase core domain; Region: rve; pfam00665
591020000275	Integrase core domain; Region: rve_3; pfam13683
591020000276	Transposase; Region: DDE_Tnp_ISL3; pfam01610
591020000277	Putative transposase; Region: Y2_Tnp; pfam04986
591020000278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
591020000279	HTH-like domain; Region: HTH_21; pfam13276
591020000280	EspG protein; Region: EspG; pfam06872
591020000281	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
591020000282	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
591020000283	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020000284	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591020000285	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020000286	HTH-like domain; Region: HTH_21; pfam13276
591020000287	Integrase core domain; Region: rve; pfam00665
591020000288	Integrase core domain; Region: rve_3; pfam13683
591020000289	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
591020000290	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
591020000291	active site
591020000292	metal binding site [ion binding]; metal-binding site
591020000293	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591020000294	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
591020000295	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
591020000296	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
591020000297	putative active site [active]
591020000298	putative NTP binding site [chemical binding]; other site
591020000299	putative nucleic acid binding site [nucleotide binding]; other site
591020000300	Integrase core domain; Region: rve; pfam00665
591020000301	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
591020000302	active site
591020000303	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591020000304	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020000305	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
591020000306	RelB antitoxin; Region: RelB; cl01171
591020000307	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
591020000308	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
591020000309	PRTRC system protein D; Region: PRTRC_D; TIGR03739
591020000310	Mg binding site [ion binding]; other site
591020000311	nucleotide binding site [chemical binding]; other site
591020000312	putative protofilament interface [polypeptide binding]; other site
591020000313	Protein of unknown function (DUF1281); Region: DUF1281; pfam06924
591020000314	putative methylase; Provisional; Region: PRK13699
591020000315	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
591020000316	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
591020000317	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
591020000318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
591020000319	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020000320	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020000321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000322	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000323	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020000324	putative transposase OrfB; Reviewed; Region: PHA02517
591020000325	Integrase core domain; Region: rve; pfam00665
591020000326	Integrase core domain; Region: rve_3; pfam13683
591020000327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000328	Transposase; Region: HTH_Tnp_1; pfam01527
591020000329	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020000330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000331	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020000332	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020000333	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000334	Homeodomain-like domain; Region: HTH_23; pfam13384
591020000335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000336	Transposase; Region: HTH_Tnp_1; pfam01527
591020000337	Transposase; Region: HTH_Tnp_1; cl17663
591020000338	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000339	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020000340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000341	HTH-like domain; Region: HTH_21; pfam13276
591020000342	Integrase core domain; Region: rve; pfam00665
591020000343	Homeodomain-like domain; Region: HTH_23; pfam13384
591020000344	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000345	Transposase; Region: HTH_Tnp_1; pfam01527
591020000346	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020000347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000348	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020000349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000350	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020000351	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000352	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020000353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591020000354	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
591020000355	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
591020000356	Predicted transcriptional regulator [Transcription]; Region: COG3905
591020000357	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
591020000358	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000359	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000360	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020000361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020000362	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020000363	plasmid maintenance protein CcdA; Provisional; Region: PRK13710
591020000364	plasmid maintenance protein CcdB; Provisional; Region: PRK13708
591020000365	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020000366	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
591020000367	Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364
591020000368	RelB antitoxin; Region: RelB; cl01171
591020000369	serine/threonine protein kinase; Provisional; Region: PRK14879
591020000370	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020000371	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020000372	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020000373	HTH-like domain; Region: HTH_21; pfam13276
591020000374	Integrase core domain; Region: rve; pfam00665
591020000375	Integrase core domain; Region: rve_3; pfam13683
591020000376	putative transposase OrfB; Reviewed; Region: PHA02517
591020000377	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
591020000378	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
591020000379	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
591020000380	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
591020000381	putative active site [active]
591020000382	putative metal binding site [ion binding]; other site
591020000383	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591020000384	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
591020000385	Protein of unknown function (DUF535); Region: DUF535; pfam04393
591020000386	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591020000387	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591020000388	putative acyl-acceptor binding pocket; other site
591020000389	Winged helix-turn helix; Region: HTH_29; pfam13551
591020000390	Homeodomain-like domain; Region: HTH_23; pfam13384
591020000391	Homeodomain-like domain; Region: HTH_32; pfam13565
591020000392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
591020000393	DDE superfamily endonuclease; Region: DDE_3; pfam13358
591020000394	putative transposase OrfB; Reviewed; Region: PHA02517
591020000395	Integrase core domain; Region: rve; pfam00665
591020000396	Integrase core domain; Region: rve_3; pfam13683
591020000397	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000398	Transposase; Region: HTH_Tnp_1; pfam01527
591020000399	conjugal transfer protein TraD; Provisional; Region: PRK13700
591020000400	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
591020000401	oligomeric interface; other site
591020000402	putative active site [active]
591020000403	homodimer interface [polypeptide binding]; other site
591020000404	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
591020000405	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
591020000406	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
591020000407	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712
591020000408	AAA domain; Region: AAA_30; pfam13604
591020000409	DNA helicase TraI; Region: TraI; pfam07057
591020000410	conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706
591020000411	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
591020000412	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
591020000413	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
591020000414	putative RNA binding sites [nucleotide binding]; other site
591020000415	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
591020000416	Catalytic site; other site
591020000417	putative transposase OrfB; Reviewed; Region: PHA02517
591020000418	Integrase core domain; Region: rve; pfam00665
591020000419	Integrase core domain; Region: rve_3; pfam13683
591020000420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000421	Transposase; Region: HTH_Tnp_1; pfam01527
591020000422	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
591020000423	Haemolysin expression modulating protein; Region: HHA; pfam05321
591020000424	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
591020000425	Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673
591020000426	replication protein; Provisional; Region: PRK13750
591020000427	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020000428	Putative transposase; Region: Y2_Tnp; pfam04986
591020000429	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
591020000430	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020000431	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
591020000432	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000433	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000434	Transposase; Region: HTH_Tnp_1; pfam01527
591020000435	putative transposase OrfB; Reviewed; Region: PHA02517
591020000436	Integrase core domain; Region: rve; pfam00665
591020000437	Integrase core domain; Region: rve_3; pfam13683
591020000438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000439	Transposase; Region: HTH_Tnp_1; pfam01527
591020000440	HTH-like domain; Region: HTH_21; pfam13276
591020000441	Integrase core domain; Region: rve; pfam00665
591020000442	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020000443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020000444	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020000445	HTH-like domain; Region: HTH_21; pfam13276
591020000446	Integrase core domain; Region: rve; pfam00665
591020000447	Integrase core domain; Region: rve_3; pfam13683
591020000448	Omptin family; Region: Omptin; pfam01278
591020000449	Replicase family; Region: Replicase; pfam03090
591020000450	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
591020000451	Sulfatase; Region: Sulfatase; cl17466
591020000452	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
591020000453	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
591020000454	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
591020000455	putative catalytic residues [active]
591020000456	putative nucleotide binding site [chemical binding]; other site
591020000457	putative aspartate binding site [chemical binding]; other site
591020000458	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
591020000459	dimer interface [polypeptide binding]; other site
591020000460	putative threonine allosteric regulatory site; other site
591020000461	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
591020000462	putative threonine allosteric regulatory site; other site
591020000463	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
591020000464	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
591020000465	homoserine kinase; Region: thrB; TIGR00191
591020000466	Protein of unknown function; Region: YhfT; pfam10797
591020000467	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591020000468	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
591020000469	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
591020000470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020000471	catalytic residue [active]
591020000472	hypothetical protein; Validated; Region: PRK02101
591020000473	transaldolase-like protein; Provisional; Region: PTZ00411
591020000474	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
591020000475	active site
591020000476	dimer interface [polypeptide binding]; other site
591020000477	catalytic residue [active]
591020000478	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
591020000479	MPT binding site; other site
591020000480	trimer interface [polypeptide binding]; other site
591020000481	hypothetical protein; Provisional; Region: PRK10659
591020000482	hypothetical protein; Provisional; Region: PRK10236
591020000483	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
591020000484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
591020000485	hypothetical protein; Provisional; Region: PRK10154
591020000486	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
591020000487	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
591020000488	nucleotide binding site [chemical binding]; other site
591020000489	NEF interaction site [polypeptide binding]; other site
591020000490	SBD interface [polypeptide binding]; other site
591020000491	chaperone protein DnaJ; Provisional; Region: PRK10767
591020000492	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591020000493	HSP70 interaction site [polypeptide binding]; other site
591020000494	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
591020000495	substrate binding site [polypeptide binding]; other site
591020000496	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
591020000497	Zn binding sites [ion binding]; other site
591020000498	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
591020000499	dimer interface [polypeptide binding]; other site
591020000500	Hok/gef family; Region: HOK_GEF; pfam01848
591020000501	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
591020000502	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
591020000503	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020000504	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
591020000505	putative dimerization interface [polypeptide binding]; other site
591020000506	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000507	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
591020000508	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
591020000509	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
591020000510	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
591020000511	active site
591020000512	Riboflavin kinase; Region: Flavokinase; smart00904
591020000513	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
591020000514	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
591020000515	HIGH motif; other site
591020000516	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
591020000517	active site
591020000518	KMSKS motif; other site
591020000519	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
591020000520	tRNA binding surface [nucleotide binding]; other site
591020000521	anticodon binding site; other site
591020000522	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591020000523	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
591020000524	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
591020000525	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591020000526	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
591020000527	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
591020000528	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
591020000529	active site
591020000530	tetramer interface [polypeptide binding]; other site
591020000531	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
591020000532	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
591020000533	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
591020000534	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
591020000535	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
591020000536	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
591020000537	catalytic site [active]
591020000538	subunit interface [polypeptide binding]; other site
591020000539	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
591020000540	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591020000541	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
591020000542	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
591020000543	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591020000544	ATP-grasp domain; Region: ATP-grasp_4; cl17255
591020000545	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
591020000546	IMP binding site; other site
591020000547	dimer interface [polypeptide binding]; other site
591020000548	interdomain contacts; other site
591020000549	partial ornithine binding site; other site
591020000550	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
591020000551	carnitine operon protein CaiE; Provisional; Region: PRK13627
591020000552	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
591020000553	putative trimer interface [polypeptide binding]; other site
591020000554	putative metal binding site [ion binding]; other site
591020000555	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
591020000556	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591020000557	substrate binding site [chemical binding]; other site
591020000558	oxyanion hole (OAH) forming residues; other site
591020000559	trimer interface [polypeptide binding]; other site
591020000560	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
591020000561	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
591020000562	acyl-activating enzyme (AAE) consensus motif; other site
591020000563	putative AMP binding site [chemical binding]; other site
591020000564	putative active site [active]
591020000565	putative CoA binding site [chemical binding]; other site
591020000566	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
591020000567	CoA-transferase family III; Region: CoA_transf_3; pfam02515
591020000568	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
591020000569	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
591020000570	active site
591020000571	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
591020000572	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
591020000573	Ligand binding site [chemical binding]; other site
591020000574	Electron transfer flavoprotein domain; Region: ETF; pfam01012
591020000575	putative oxidoreductase FixC; Provisional; Region: PRK10157
591020000576	ferredoxin-like protein FixX; Provisional; Region: PRK15449
591020000577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020000578	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
591020000579	putative substrate translocation pore; other site
591020000580	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
591020000581	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
591020000582	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
591020000583	TrkA-N domain; Region: TrkA_N; pfam02254
591020000584	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
591020000585	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
591020000586	folate binding site [chemical binding]; other site
591020000587	NADP+ binding site [chemical binding]; other site
591020000588	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
591020000589	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
591020000590	active site
591020000591	metal binding site [ion binding]; metal-binding site
591020000592	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
591020000593	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
591020000594	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
591020000595	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
591020000596	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
591020000597	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
591020000598	SurA N-terminal domain; Region: SurA_N; pfam09312
591020000599	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
591020000600	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
591020000601	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
591020000602	OstA-like protein; Region: OstA; pfam03968
591020000603	Organic solvent tolerance protein; Region: OstA_C; pfam04453
591020000604	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
591020000605	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
591020000606	putative metal binding site [ion binding]; other site
591020000607	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591020000608	HSP70 interaction site [polypeptide binding]; other site
591020000609	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
591020000610	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591020000611	active site
591020000612	ATP-dependent helicase HepA; Validated; Region: PRK04914
591020000613	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020000614	ATP binding site [chemical binding]; other site
591020000615	putative Mg++ binding site [ion binding]; other site
591020000616	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020000617	nucleotide binding region [chemical binding]; other site
591020000618	ATP-binding site [chemical binding]; other site
591020000619	DNA polymerase II; Reviewed; Region: PRK05762
591020000620	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
591020000621	active site
591020000622	catalytic site [active]
591020000623	substrate binding site [chemical binding]; other site
591020000624	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
591020000625	active site
591020000626	metal-binding site
591020000627	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
591020000628	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591020000629	intersubunit interface [polypeptide binding]; other site
591020000630	active site
591020000631	Zn2+ binding site [ion binding]; other site
591020000632	L-arabinose isomerase; Provisional; Region: PRK02929
591020000633	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
591020000634	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
591020000635	trimer interface [polypeptide binding]; other site
591020000636	putative substrate binding site [chemical binding]; other site
591020000637	putative metal binding site [ion binding]; other site
591020000638	ribulokinase; Provisional; Region: PRK04123
591020000639	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
591020000640	N- and C-terminal domain interface [polypeptide binding]; other site
591020000641	active site
591020000642	MgATP binding site [chemical binding]; other site
591020000643	catalytic site [active]
591020000644	metal binding site [ion binding]; metal-binding site
591020000645	carbohydrate binding site [chemical binding]; other site
591020000646	homodimer interface [polypeptide binding]; other site
591020000647	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
591020000648	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591020000649	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020000650	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020000651	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591020000652	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591020000653	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
591020000654	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
591020000655	Walker A/P-loop; other site
591020000656	ATP binding site [chemical binding]; other site
591020000657	Q-loop/lid; other site
591020000658	ABC transporter signature motif; other site
591020000659	Walker B; other site
591020000660	D-loop; other site
591020000661	H-loop/switch region; other site
591020000662	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
591020000663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020000664	dimer interface [polypeptide binding]; other site
591020000665	conserved gate region; other site
591020000666	putative PBP binding loops; other site
591020000667	ABC-ATPase subunit interface; other site
591020000668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020000669	dimer interface [polypeptide binding]; other site
591020000670	conserved gate region; other site
591020000671	putative PBP binding loops; other site
591020000672	ABC-ATPase subunit interface; other site
591020000673	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
591020000674	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
591020000675	transcriptional regulator SgrR; Provisional; Region: PRK13626
591020000676	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
591020000677	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
591020000678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020000679	sugar efflux transporter; Region: 2A0120; TIGR00899
591020000680	putative substrate translocation pore; other site
591020000681	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
591020000682	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
591020000683	substrate binding site [chemical binding]; other site
591020000684	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
591020000685	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
591020000686	substrate binding site [chemical binding]; other site
591020000687	ligand binding site [chemical binding]; other site
591020000688	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
591020000689	tartrate dehydrogenase; Region: TTC; TIGR02089
591020000690	2-isopropylmalate synthase; Validated; Region: PRK00915
591020000691	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
591020000692	active site
591020000693	catalytic residues [active]
591020000694	metal binding site [ion binding]; metal-binding site
591020000695	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
591020000696	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
591020000697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020000698	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
591020000699	putative substrate binding pocket [chemical binding]; other site
591020000700	putative dimerization interface [polypeptide binding]; other site
591020000701	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
591020000702	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591020000703	PYR/PP interface [polypeptide binding]; other site
591020000704	dimer interface [polypeptide binding]; other site
591020000705	TPP binding site [chemical binding]; other site
591020000706	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591020000707	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
591020000708	TPP-binding site [chemical binding]; other site
591020000709	dimer interface [polypeptide binding]; other site
591020000710	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
591020000711	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
591020000712	putative valine binding site [chemical binding]; other site
591020000713	dimer interface [polypeptide binding]; other site
591020000714	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
591020000715	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
591020000716	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020000717	DNA binding site [nucleotide binding]
591020000718	domain linker motif; other site
591020000719	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
591020000720	dimerization interface [polypeptide binding]; other site
591020000721	ligand binding site [chemical binding]; other site
591020000722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
591020000723	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
591020000724	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
591020000725	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000726	mraZ protein; Region: TIGR00242
591020000727	MraZ protein; Region: MraZ; pfam02381
591020000728	MraZ protein; Region: MraZ; pfam02381
591020000729	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
591020000730	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
591020000731	cell division protein FtsL; Provisional; Region: PRK10772
591020000732	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
591020000733	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
591020000734	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
591020000735	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
591020000736	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591020000737	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591020000738	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591020000739	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
591020000740	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591020000741	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591020000742	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591020000743	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
591020000744	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
591020000745	Mg++ binding site [ion binding]; other site
591020000746	putative catalytic motif [active]
591020000747	putative substrate binding site [chemical binding]; other site
591020000748	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
591020000749	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591020000750	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591020000751	cell division protein FtsW; Provisional; Region: PRK10774
591020000752	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
591020000753	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
591020000754	active site
591020000755	homodimer interface [polypeptide binding]; other site
591020000756	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
591020000757	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591020000758	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591020000759	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591020000760	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
591020000761	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
591020000762	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
591020000763	cell division protein FtsQ; Provisional; Region: PRK10775
591020000764	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
591020000765	Cell division protein FtsQ; Region: FtsQ; pfam03799
591020000766	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
591020000767	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591020000768	Cell division protein FtsA; Region: FtsA; pfam14450
591020000769	cell division protein FtsZ; Validated; Region: PRK09330
591020000770	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
591020000771	nucleotide binding site [chemical binding]; other site
591020000772	SulA interaction site; other site
591020000773	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
591020000774	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
591020000775	SecA regulator SecM; Provisional; Region: PRK02943
591020000776	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
591020000777	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
591020000778	SEC-C motif; Region: SEC-C; pfam02810
591020000779	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
591020000780	active site
591020000781	8-oxo-dGMP binding site [chemical binding]; other site
591020000782	nudix motif; other site
591020000783	metal binding site [ion binding]; metal-binding site
591020000784	DNA gyrase inhibitor; Reviewed; Region: PRK00418
591020000785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
591020000786	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
591020000787	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
591020000788	CoA-binding site [chemical binding]; other site
591020000789	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
591020000790	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
591020000791	active site
591020000792	type IV pilin biogenesis protein; Provisional; Region: PRK10573
591020000793	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591020000794	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
591020000795	putative major pilin subunit; Provisional; Region: PRK10574
591020000796	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
591020000797	Pilin (bacterial filament); Region: Pilin; pfam00114
591020000798	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
591020000799	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
591020000800	dimerization interface [polypeptide binding]; other site
591020000801	active site
591020000802	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
591020000803	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
591020000804	amidase catalytic site [active]
591020000805	Zn binding residues [ion binding]; other site
591020000806	substrate binding site [chemical binding]; other site
591020000807	regulatory protein AmpE; Provisional; Region: PRK10987
591020000808	aromatic amino acid transporter; Provisional; Region: PRK10238
591020000809	Transcriptional regulators [Transcription]; Region: FadR; COG2186
591020000810	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020000811	DNA-binding site [nucleotide binding]; DNA binding site
591020000812	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591020000813	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
591020000814	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
591020000815	dimer interface [polypeptide binding]; other site
591020000816	TPP-binding site [chemical binding]; other site
591020000817	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
591020000818	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591020000819	E3 interaction surface; other site
591020000820	lipoyl attachment site [posttranslational modification]; other site
591020000821	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591020000822	E3 interaction surface; other site
591020000823	lipoyl attachment site [posttranslational modification]; other site
591020000824	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591020000825	E3 interaction surface; other site
591020000826	lipoyl attachment site [posttranslational modification]; other site
591020000827	e3 binding domain; Region: E3_binding; pfam02817
591020000828	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
591020000829	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
591020000830	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
591020000831	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020000832	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591020000833	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
591020000834	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
591020000835	substrate binding site [chemical binding]; other site
591020000836	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
591020000837	substrate binding site [chemical binding]; other site
591020000838	ligand binding site [chemical binding]; other site
591020000839	hypothetical protein; Provisional; Region: PRK05248
591020000840	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
591020000841	spermidine synthase; Provisional; Region: PRK00811
591020000842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020000843	S-adenosylmethionine binding site [chemical binding]; other site
591020000844	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
591020000845	multicopper oxidase; Provisional; Region: PRK10965
591020000846	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
591020000847	Multicopper oxidase; Region: Cu-oxidase; pfam00394
591020000848	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
591020000849	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
591020000850	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
591020000851	Trp docking motif [polypeptide binding]; other site
591020000852	putative active site [active]
591020000853	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
591020000854	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020000855	active site
591020000856	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
591020000857	active site clefts [active]
591020000858	zinc binding site [ion binding]; other site
591020000859	dimer interface [polypeptide binding]; other site
591020000860	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591020000861	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591020000862	Walker A/P-loop; other site
591020000863	ATP binding site [chemical binding]; other site
591020000864	Q-loop/lid; other site
591020000865	ABC transporter signature motif; other site
591020000866	Walker B; other site
591020000867	D-loop; other site
591020000868	H-loop/switch region; other site
591020000869	inner membrane transport permease; Provisional; Region: PRK15066
591020000870	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591020000871	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591020000872	active pocket/dimerization site; other site
591020000873	active site
591020000874	phosphorylation site [posttranslational modification]
591020000875	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
591020000876	putative active site [active]
591020000877	putative metal binding site [ion binding]; other site
591020000878	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
591020000879	tetramerization interface [polypeptide binding]; other site
591020000880	active site
591020000881	Uncharacterized conserved protein [Function unknown]; Region: COG5464
591020000882	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591020000883	pantoate--beta-alanine ligase; Region: panC; TIGR00018
591020000884	Pantoate-beta-alanine ligase; Region: PanC; cd00560
591020000885	active site
591020000886	ATP-binding site [chemical binding]; other site
591020000887	pantoate-binding site; other site
591020000888	HXXH motif; other site
591020000889	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
591020000890	oligomerization interface [polypeptide binding]; other site
591020000891	active site
591020000892	metal binding site [ion binding]; metal-binding site
591020000893	Fimbrial protein; Region: Fimbrial; cl01416
591020000894	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020000895	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
591020000896	catalytic center binding site [active]
591020000897	ATP binding site [chemical binding]; other site
591020000898	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
591020000899	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
591020000900	active site
591020000901	NTP binding site [chemical binding]; other site
591020000902	metal binding triad [ion binding]; metal-binding site
591020000903	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
591020000904	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
591020000905	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
591020000906	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
591020000907	active site
591020000908	nucleotide binding site [chemical binding]; other site
591020000909	HIGH motif; other site
591020000910	KMSKS motif; other site
591020000911	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
591020000912	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
591020000913	2'-5' RNA ligase; Provisional; Region: PRK15124
591020000914	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
591020000915	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
591020000916	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
591020000917	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020000918	ATP binding site [chemical binding]; other site
591020000919	putative Mg++ binding site [ion binding]; other site
591020000920	nucleotide binding region [chemical binding]; other site
591020000921	helicase superfamily c-terminal domain; Region: HELICc; smart00490
591020000922	ATP-binding site [chemical binding]; other site
591020000923	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
591020000924	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
591020000925	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
591020000926	Transglycosylase; Region: Transgly; pfam00912
591020000927	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591020000928	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
591020000929	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591020000930	N-terminal plug; other site
591020000931	ligand-binding site [chemical binding]; other site
591020000932	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
591020000933	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591020000934	Walker A/P-loop; other site
591020000935	ATP binding site [chemical binding]; other site
591020000936	Q-loop/lid; other site
591020000937	ABC transporter signature motif; other site
591020000938	Walker B; other site
591020000939	D-loop; other site
591020000940	H-loop/switch region; other site
591020000941	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
591020000942	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
591020000943	siderophore binding site; other site
591020000944	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591020000945	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020000946	ABC-ATPase subunit  interface; other site
591020000947	dimer interface [polypeptide binding]; other site
591020000948	putative PBP binding regions; other site
591020000949	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020000950	ABC-ATPase subunit  interface; other site
591020000951	dimer interface [polypeptide binding]; other site
591020000952	putative PBP binding regions; other site
591020000953	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
591020000954	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591020000955	inhibitor-cofactor binding pocket; inhibition site
591020000956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020000957	catalytic residue [active]
591020000958	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591020000959	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
591020000960	Cl- selectivity filter; other site
591020000961	Cl- binding residues [ion binding]; other site
591020000962	pore gating glutamate residue; other site
591020000963	dimer interface [polypeptide binding]; other site
591020000964	H+/Cl- coupling transport residue; other site
591020000965	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
591020000966	hypothetical protein; Provisional; Region: PRK10578
591020000967	UPF0126 domain; Region: UPF0126; pfam03458
591020000968	UPF0126 domain; Region: UPF0126; pfam03458
591020000969	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
591020000970	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
591020000971	cobalamin binding residues [chemical binding]; other site
591020000972	putative BtuC binding residues; other site
591020000973	dimer interface [polypeptide binding]; other site
591020000974	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
591020000975	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
591020000976	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
591020000977	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591020000978	Zn2+ binding site [ion binding]; other site
591020000979	Mg2+ binding site [ion binding]; other site
591020000980	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
591020000981	serine endoprotease; Provisional; Region: PRK10942
591020000982	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
591020000983	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591020000984	protein binding site [polypeptide binding]; other site
591020000985	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591020000986	hypothetical protein; Provisional; Region: PRK13677
591020000987	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
591020000988	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
591020000989	trimer interface [polypeptide binding]; other site
591020000990	active site
591020000991	substrate binding site [chemical binding]; other site
591020000992	CoA binding site [chemical binding]; other site
591020000993	PII uridylyl-transferase; Provisional; Region: PRK05007
591020000994	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
591020000995	metal binding triad; other site
591020000996	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
591020000997	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591020000998	Zn2+ binding site [ion binding]; other site
591020000999	Mg2+ binding site [ion binding]; other site
591020001000	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
591020001001	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
591020001002	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
591020001003	active site
591020001004	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
591020001005	rRNA interaction site [nucleotide binding]; other site
591020001006	S8 interaction site; other site
591020001007	putative laminin-1 binding site; other site
591020001008	elongation factor Ts; Provisional; Region: tsf; PRK09377
591020001009	UBA/TS-N domain; Region: UBA; pfam00627
591020001010	Elongation factor TS; Region: EF_TS; pfam00889
591020001011	Elongation factor TS; Region: EF_TS; pfam00889
591020001012	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
591020001013	putative nucleotide binding site [chemical binding]; other site
591020001014	uridine monophosphate binding site [chemical binding]; other site
591020001015	homohexameric interface [polypeptide binding]; other site
591020001016	ribosome recycling factor; Reviewed; Region: frr; PRK00083
591020001017	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
591020001018	hinge region; other site
591020001019	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
591020001020	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
591020001021	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
591020001022	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
591020001023	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
591020001024	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
591020001025	catalytic residue [active]
591020001026	putative FPP diphosphate  binding site; other site
591020001027	putative FPP binding hydrophobic cleft; other site
591020001028	dimer interface [polypeptide binding]; other site
591020001029	putative IPP diphosphate binding site; other site
591020001030	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
591020001031	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
591020001032	zinc metallopeptidase RseP; Provisional; Region: PRK10779
591020001033	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
591020001034	active site
591020001035	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
591020001036	protein binding site [polypeptide binding]; other site
591020001037	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
591020001038	putative substrate binding region [chemical binding]; other site
591020001039	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
591020001040	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591020001041	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591020001042	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591020001043	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591020001044	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591020001045	Surface antigen; Region: Bac_surface_Ag; pfam01103
591020001046	periplasmic chaperone; Provisional; Region: PRK10780
591020001047	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
591020001048	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
591020001049	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
591020001050	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
591020001051	trimer interface [polypeptide binding]; other site
591020001052	active site
591020001053	UDP-GlcNAc binding site [chemical binding]; other site
591020001054	lipid binding site [chemical binding]; lipid-binding site
591020001055	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
591020001056	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
591020001057	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
591020001058	active site
591020001059	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
591020001060	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
591020001061	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
591020001062	RNA/DNA hybrid binding site [nucleotide binding]; other site
591020001063	active site
591020001064	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
591020001065	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
591020001066	putative active site [active]
591020001067	putative PHP Thumb interface [polypeptide binding]; other site
591020001068	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
591020001069	generic binding surface II; other site
591020001070	generic binding surface I; other site
591020001071	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
591020001072	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
591020001073	lysine decarboxylase LdcC; Provisional; Region: PRK15399
591020001074	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591020001075	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591020001076	homodimer interface [polypeptide binding]; other site
591020001077	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020001078	catalytic residue [active]
591020001079	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591020001080	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
591020001081	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591020001082	putative metal binding site [ion binding]; other site
591020001083	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
591020001084	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
591020001085	Ligand Binding Site [chemical binding]; other site
591020001086	TilS substrate binding domain; Region: TilS; pfam09179
591020001087	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
591020001088	Rho-binding antiterminator; Provisional; Region: PRK11625
591020001089	hypothetical protein; Provisional; Region: PRK04964
591020001090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
591020001091	hypothetical protein; Provisional; Region: PRK09256
591020001092	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
591020001093	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
591020001094	NlpE N-terminal domain; Region: NlpE; pfam04170
591020001095	hypothetical protein; Provisional; Region: PRK11479
591020001096	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
591020001097	prolyl-tRNA synthetase; Provisional; Region: PRK09194
591020001098	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
591020001099	dimer interface [polypeptide binding]; other site
591020001100	motif 1; other site
591020001101	active site
591020001102	motif 2; other site
591020001103	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
591020001104	putative deacylase active site [active]
591020001105	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
591020001106	active site
591020001107	motif 3; other site
591020001108	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
591020001109	anticodon binding site; other site
591020001110	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
591020001111	homodimer interaction site [polypeptide binding]; other site
591020001112	cofactor binding site; other site
591020001113	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
591020001114	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
591020001115	lipoprotein, YaeC family; Region: TIGR00363
591020001116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020001117	dimer interface [polypeptide binding]; other site
591020001118	conserved gate region; other site
591020001119	ABC-ATPase subunit interface; other site
591020001120	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
591020001121	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
591020001122	Walker A/P-loop; other site
591020001123	ATP binding site [chemical binding]; other site
591020001124	Q-loop/lid; other site
591020001125	ABC transporter signature motif; other site
591020001126	Walker B; other site
591020001127	D-loop; other site
591020001128	H-loop/switch region; other site
591020001129	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
591020001130	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
591020001131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020001132	active site
591020001133	motif I; other site
591020001134	motif II; other site
591020001135	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020001136	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020001137	active site
591020001138	catalytic tetrad [active]
591020001139	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020001140	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020001141	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020001142	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591020001143	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020001144	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
591020001145	putative effector binding pocket; other site
591020001146	dimerization interface [polypeptide binding]; other site
591020001147	hypothetical protein; Provisional; Region: PRK05421
591020001148	putative catalytic site [active]
591020001149	putative metal binding site [ion binding]; other site
591020001150	putative phosphate binding site [ion binding]; other site
591020001151	putative catalytic site [active]
591020001152	putative phosphate binding site [ion binding]; other site
591020001153	putative metal binding site [ion binding]; other site
591020001154	Methyltransferase domain; Region: Methyltransf_31; pfam13847
591020001155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020001156	S-adenosylmethionine binding site [chemical binding]; other site
591020001157	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
591020001158	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020001159	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020001160	catalytic residue [active]
591020001161	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020001162	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020001163	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
591020001164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020001165	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
591020001166	RNA/DNA hybrid binding site [nucleotide binding]; other site
591020001167	active site
591020001168	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
591020001169	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
591020001170	active site
591020001171	catalytic site [active]
591020001172	substrate binding site [chemical binding]; other site
591020001173	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
591020001174	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
591020001175	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
591020001176	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
591020001177	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
591020001178	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
591020001179	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
591020001180	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
591020001181	ImpE protein; Region: ImpE; pfam07024
591020001182	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
591020001183	Transposase; Region: HTH_Tnp_1; cl17663
591020001184	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020001185	Integrase core domain; Region: rve; pfam00665
591020001186	Integrase core domain; Region: rve_3; pfam13683
591020001187	Terminase-like family; Region: Terminase_6; pfam03237
591020001188	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
591020001189	Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306
591020001190	coat protein; Region: PHA01511
591020001191	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
591020001192	P22 tail accessory factor; Region: P22_Tail-4; pfam11650
591020001193	Phage stabilisation protein; Region: Phage_stabilise; pfam11134
591020001194	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
591020001195	Protein of unknown function (DUF2824); Region: DUF2824; pfam11039
591020001196	Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685
591020001197	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
591020001198	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020001199	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020001200	catalytic residue [active]
591020001201	Transposase; Region: HTH_Tnp_1; cl17663
591020001202	HTH-like domain; Region: HTH_21; pfam13276
591020001203	Integrase core domain; Region: rve; pfam00665
591020001204	Integrase core domain; Region: rve_3; pfam13683
591020001205	hypothetical protein; Provisional; Region: PRK11505
591020001206	psiF repeat; Region: PsiF_repeat; pfam07769
591020001207	psiF repeat; Region: PsiF_repeat; pfam07769
591020001208	alkaline phosphatase; Provisional; Region: PRK10518
591020001209	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
591020001210	dimer interface [polypeptide binding]; other site
591020001211	active site
591020001212	anti-RssB factor; Provisional; Region: PRK10244
591020001213	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
591020001214	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
591020001215	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
591020001216	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
591020001217	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
591020001218	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
591020001219	microcin B17 transporter; Reviewed; Region: PRK11098
591020001220	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
591020001221	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
591020001222	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
591020001223	Autotransporter beta-domain; Region: Autotransporter; smart00869
591020001224	putative transposase OrfB; Reviewed; Region: PHA02517
591020001225	HTH-like domain; Region: HTH_21; pfam13276
591020001226	Integrase core domain; Region: rve; pfam00665
591020001227	Integrase core domain; Region: rve_2; pfam13333
591020001228	putative transposase OrfB; Reviewed; Region: PHA02517
591020001229	Integrase core domain; Region: rve; pfam00665
591020001230	Integrase core domain; Region: rve_3; pfam13683
591020001231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020001232	Transposase; Region: HTH_Tnp_1; cl17663
591020001233	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020001234	HTH-like domain; Region: HTH_21; pfam13276
591020001235	Integrase core domain; Region: rve; pfam00665
591020001236	Integrase core domain; Region: rve_3; pfam13683
591020001237	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001238	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
591020001239	dimer interface [polypeptide binding]; other site
591020001240	active site
591020001241	Schiff base residues; other site
591020001242	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
591020001243	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
591020001244	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
591020001245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020001246	dimer interface [polypeptide binding]; other site
591020001247	conserved gate region; other site
591020001248	putative PBP binding loops; other site
591020001249	ABC-ATPase subunit interface; other site
591020001250	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
591020001251	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
591020001252	Walker A/P-loop; other site
591020001253	ATP binding site [chemical binding]; other site
591020001254	Q-loop/lid; other site
591020001255	ABC transporter signature motif; other site
591020001256	Walker B; other site
591020001257	D-loop; other site
591020001258	H-loop/switch region; other site
591020001259	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
591020001260	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020001261	substrate binding pocket [chemical binding]; other site
591020001262	membrane-bound complex binding site; other site
591020001263	hinge residues; other site
591020001264	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001265	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
591020001266	Uncharacterized conserved protein [Function unknown]; Region: COG1556
591020001267	iron-sulfur cluster-binding protein; Region: TIGR00273
591020001268	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
591020001269	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591020001270	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
591020001271	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
591020001272	Cysteine-rich domain; Region: CCG; pfam02754
591020001273	Cysteine-rich domain; Region: CCG; pfam02754
591020001274	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001275	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
591020001276	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
591020001277	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
591020001278	PAAR motif; Region: PAAR_motif; pfam05488
591020001279	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
591020001280	RHS Repeat; Region: RHS_repeat; pfam05593
591020001281	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
591020001282	RHS protein; Region: RHS; pfam03527
591020001283	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
591020001284	C-N hydrolase family amidase; Provisional; Region: PRK10438
591020001285	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
591020001286	putative active site [active]
591020001287	catalytic triad [active]
591020001288	dimer interface [polypeptide binding]; other site
591020001289	multimer interface [polypeptide binding]; other site
591020001290	C-lysozyme inhibitor; Provisional; Region: PRK09993
591020001291	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
591020001292	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
591020001293	active site
591020001294	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
591020001295	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
591020001296	dimer interface [polypeptide binding]; other site
591020001297	active site
591020001298	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
591020001299	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
591020001300	putative active site [active]
591020001301	putative dimer interface [polypeptide binding]; other site
591020001302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
591020001303	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591020001304	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591020001305	NlpC/P60 family; Region: NLPC_P60; pfam00877
591020001306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
591020001307	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
591020001308	FHIPEP family; Region: FHIPEP; pfam00771
591020001309	hypothetical protein; Validated; Region: PRK06778
591020001310	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591020001311	ligand binding site [chemical binding]; other site
591020001312	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
591020001313	active site
591020001314	DNA polymerase IV; Validated; Region: PRK02406
591020001315	DNA binding site [nucleotide binding]
591020001316	putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778
591020001317	putative toxin YafO; Provisional; Region: PRK09885
591020001318	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591020001319	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020001320	Coenzyme A binding pocket [chemical binding]; other site
591020001321	hypothetical protein; Reviewed; Region: PRK09588
591020001322	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
591020001323	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
591020001324	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
591020001325	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
591020001326	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
591020001327	metal binding site [ion binding]; metal-binding site
591020001328	dimer interface [polypeptide binding]; other site
591020001329	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020001330	active site
591020001331	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
591020001332	Transcriptional regulator Crl; Region: Crl; cl11653
591020001333	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591020001334	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591020001335	trimer interface [polypeptide binding]; other site
591020001336	eyelet of channel; other site
591020001337	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001338	gamma-glutamyl kinase; Provisional; Region: PRK05429
591020001339	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
591020001340	nucleotide binding site [chemical binding]; other site
591020001341	homotetrameric interface [polypeptide binding]; other site
591020001342	putative phosphate binding site [ion binding]; other site
591020001343	putative allosteric binding site; other site
591020001344	PUA domain; Region: PUA; pfam01472
591020001345	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
591020001346	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
591020001347	putative catalytic cysteine [active]
591020001348	SHI-O island
591020001349	integrase; Provisional; Region: int; PHA02601
591020001350	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
591020001351	Int/Topo IB signature motif; other site
591020001352	Helix-turn-helix domain; Region: HTH_17; pfam12728
591020001353	xylulokinase; Provisional; Region: PRK15027
591020001354	hypothetical protein; Region: PHA00626
591020001355	Protein of unknown function (DUF551); Region: DUF551; pfam04448
591020001356	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
591020001357	Protein of unknown function (DUF2737); Region: DUF2737; pfam10930
591020001358	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
591020001359	RecT family; Region: RecT; pfam03837
591020001360	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
591020001361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020001362	non-specific DNA binding site [nucleotide binding]; other site
591020001363	salt bridge; other site
591020001364	sequence-specific DNA binding site [nucleotide binding]; other site
591020001365	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591020001366	Catalytic site [active]
591020001367	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020001368	non-specific DNA binding site [nucleotide binding]; other site
591020001369	salt bridge; other site
591020001370	sequence-specific DNA binding site [nucleotide binding]; other site
591020001371	Bacteriophage CII protein; Region: Phage_CII; pfam05269
591020001372	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
591020001373	phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600
591020001374	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
591020001375	Walker A motif; other site
591020001376	ATP binding site [chemical binding]; other site
591020001377	Walker B motif; other site
591020001378	NinB protein; Region: NinB; pfam05772
591020001379	NINE Protein; Region: NinE; pfam05322
591020001380	NinF protein; Region: NinF; pfam05810
591020001381	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
591020001382	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
591020001383	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
591020001384	Endodeoxyribonuclease RusA; Region: RusA; cl01885
591020001385	Phage NinH protein; Region: Phage_NinH; pfam06322
591020001386	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
591020001387	phage holin, lambda family; Region: holin_lambda; TIGR01594
591020001388	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
591020001389	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020001390	catalytic residue [active]
591020001391	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
591020001392	T5orf172 domain; Region: T5orf172; pfam10544
591020001393	Protein of unknown function (DUF2560); Region: DUF2560; pfam10834
591020001394	hypothetical protein; Region: PHA00781
591020001395	Terminase-like family; Region: Terminase_6; pfam03237
591020001396	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
591020001397	Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306
591020001398	coat protein; Region: PHA01511
591020001399	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
591020001400	P22 tail accessory factor; Region: P22_Tail-4; pfam11650
591020001401	Phage stabilisation protein; Region: Phage_stabilise; pfam11134
591020001402	Protein of unknown function (DUF2824); Region: DUF2824; pfam11039
591020001403	Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685
591020001404	Mnt; Region: mnt; PHA01513
591020001405	Arc-like DNA binding domain; Region: Arc; pfam03869
591020001406	Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423
591020001407	HNH endonuclease; Region: HNH_3; pfam13392
591020001408	AP2 domain; Region: AP2; pfam00847
591020001409	Head binding; Region: Head_binding; pfam09008
591020001410	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
591020001411	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
591020001412	Ligand binding site; other site
591020001413	Putative Catalytic site; other site
591020001414	DXD motif; other site
591020001415	Predicted membrane protein [Function unknown]; Region: COG2246
591020001416	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020001417	DNA binding site [nucleotide binding]
591020001418	Int/Topo IB signature motif; other site
591020001419	active site
591020001420	putative transposase OrfB; Reviewed; Region: PHA02517
591020001421	Integrase core domain; Region: rve; pfam00665
591020001422	Integrase core domain; Region: rve_3; pfam13683
591020001423	HTH-like domain; Region: HTH_21; pfam13276
591020001424	Integrase core domain; Region: rve; pfam00665
591020001425	Integrase core domain; Region: rve_3; pfam13683
591020001426	Transposase; Region: HTH_Tnp_1; cl17663
591020001427	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
591020001428	MASE2 domain; Region: MASE2; pfam05230
591020001429	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020001430	metal binding site [ion binding]; metal-binding site
591020001431	active site
591020001432	I-site; other site
591020001433	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
591020001434	pyrroline-5-carboxylate reductase; Region: PLN02688
591020001435	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
591020001436	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
591020001437	ADP binding site [chemical binding]; other site
591020001438	magnesium binding site [ion binding]; other site
591020001439	putative shikimate binding site; other site
591020001440	hypothetical protein; Provisional; Region: PRK10380
591020001441	hypothetical protein; Provisional; Region: PRK10481
591020001442	hypothetical protein; Provisional; Region: PRK10579
591020001443	Protein of unknown function (DUF2773); Region: DUF2773; pfam10971
591020001444	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
591020001445	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
591020001446	fructokinase; Reviewed; Region: PRK09557
591020001447	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591020001448	nucleotide binding site [chemical binding]; other site
591020001449	MFS transport protein AraJ; Provisional; Region: PRK10091
591020001450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020001451	putative substrate translocation pore; other site
591020001452	exonuclease subunit SbcC; Provisional; Region: PRK10246
591020001453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020001454	Walker A/P-loop; other site
591020001455	ATP binding site [chemical binding]; other site
591020001456	Q-loop/lid; other site
591020001457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020001458	Q-loop/lid; other site
591020001459	ABC transporter signature motif; other site
591020001460	Walker B; other site
591020001461	D-loop; other site
591020001462	H-loop/switch region; other site
591020001463	exonuclease subunit SbcD; Provisional; Region: PRK10966
591020001464	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
591020001465	active site
591020001466	metal binding site [ion binding]; metal-binding site
591020001467	DNA binding site [nucleotide binding]
591020001468	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
591020001469	transcriptional regulator PhoB; Provisional; Region: PRK10161
591020001470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020001471	active site
591020001472	phosphorylation site [posttranslational modification]
591020001473	intermolecular recognition site; other site
591020001474	dimerization interface [polypeptide binding]; other site
591020001475	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020001476	DNA binding site [nucleotide binding]
591020001477	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
591020001478	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
591020001479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591020001480	putative active site [active]
591020001481	heme pocket [chemical binding]; other site
591020001482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020001483	dimer interface [polypeptide binding]; other site
591020001484	phosphorylation site [posttranslational modification]
591020001485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020001486	ATP binding site [chemical binding]; other site
591020001487	Mg2+ binding site [ion binding]; other site
591020001488	G-X-G motif; other site
591020001489	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
591020001490	putative proline-specific permease; Provisional; Region: proY; PRK10580
591020001491	Spore germination protein; Region: Spore_permease; cl17796
591020001492	maltodextrin glucosidase; Provisional; Region: PRK10785
591020001493	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
591020001494	homodimer interface [polypeptide binding]; other site
591020001495	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
591020001496	active site
591020001497	homodimer interface [polypeptide binding]; other site
591020001498	catalytic site [active]
591020001499	Protein of unknown function, DUF479; Region: DUF479; cl01203
591020001500	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
591020001501	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
591020001502	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
591020001503	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
591020001504	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
591020001505	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
591020001506	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
591020001507	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
591020001508	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
591020001509	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
591020001510	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
591020001511	Protein export membrane protein; Region: SecD_SecF; pfam02355
591020001512	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
591020001513	active site
591020001514	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
591020001515	hypothetical protein; Provisional; Region: PRK11530
591020001516	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
591020001517	ATP cone domain; Region: ATP-cone; pfam03477
591020001518	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
591020001519	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
591020001520	catalytic motif [active]
591020001521	Zn binding site [ion binding]; other site
591020001522	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
591020001523	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
591020001524	homopentamer interface [polypeptide binding]; other site
591020001525	active site
591020001526	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
591020001527	putative RNA binding site [nucleotide binding]; other site
591020001528	thiamine monophosphate kinase; Provisional; Region: PRK05731
591020001529	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
591020001530	ATP binding site [chemical binding]; other site
591020001531	dimerization interface [polypeptide binding]; other site
591020001532	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
591020001533	tetramer interfaces [polypeptide binding]; other site
591020001534	binuclear metal-binding site [ion binding]; other site
591020001535	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020001536	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020001537	active site
591020001538	catalytic tetrad [active]
591020001539	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
591020001540	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
591020001541	TPP-binding site; other site
591020001542	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591020001543	PYR/PP interface [polypeptide binding]; other site
591020001544	dimer interface [polypeptide binding]; other site
591020001545	TPP binding site [chemical binding]; other site
591020001546	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
591020001547	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
591020001548	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
591020001549	substrate binding pocket [chemical binding]; other site
591020001550	chain length determination region; other site
591020001551	substrate-Mg2+ binding site; other site
591020001552	catalytic residues [active]
591020001553	aspartate-rich region 1; other site
591020001554	active site lid residues [active]
591020001555	aspartate-rich region 2; other site
591020001556	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
591020001557	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
591020001558	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
591020001559	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
591020001560	Ligand Binding Site [chemical binding]; other site
591020001561	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
591020001562	active site residue [active]
591020001563	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
591020001564	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
591020001565	conserved cys residue [active]
591020001566	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
591020001567	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
591020001568	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
591020001569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
591020001570	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
591020001571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
591020001572	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
591020001573	Sel1-like repeats; Region: SEL1; smart00671
591020001574	Sel1-like repeats; Region: SEL1; smart00671
591020001575	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001576	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
591020001577	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
591020001578	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
591020001579	UbiA prenyltransferase family; Region: UbiA; pfam01040
591020001580	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
591020001581	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
591020001582	Subunit I/III interface [polypeptide binding]; other site
591020001583	Subunit III/IV interface [polypeptide binding]; other site
591020001584	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
591020001585	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
591020001586	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020001587	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020001588	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020001589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020001590	Homeodomain-like domain; Region: HTH_23; pfam13384
591020001591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020001592	Transposase; Region: HTH_Tnp_1; pfam01527
591020001593	muropeptide transporter; Reviewed; Region: ampG; PRK11902
591020001594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020001595	putative substrate translocation pore; other site
591020001596	hypothetical protein; Provisional; Region: PRK11627
591020001597	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
591020001598	transcriptional regulator BolA; Provisional; Region: PRK11628
591020001599	trigger factor; Provisional; Region: tig; PRK01490
591020001600	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591020001601	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
591020001602	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
591020001603	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
591020001604	oligomer interface [polypeptide binding]; other site
591020001605	active site residues [active]
591020001606	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
591020001607	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
591020001608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020001609	Walker A motif; other site
591020001610	ATP binding site [chemical binding]; other site
591020001611	Walker B motif; other site
591020001612	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
591020001613	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
591020001614	Found in ATP-dependent protease La (LON); Region: LON; smart00464
591020001615	Found in ATP-dependent protease La (LON); Region: LON; smart00464
591020001616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020001617	Walker A motif; other site
591020001618	ATP binding site [chemical binding]; other site
591020001619	Walker B motif; other site
591020001620	arginine finger; other site
591020001621	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
591020001622	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591020001623	IHF dimer interface [polypeptide binding]; other site
591020001624	IHF - DNA interface [nucleotide binding]; other site
591020001625	periplasmic folding chaperone; Provisional; Region: PRK10788
591020001626	SurA N-terminal domain; Region: SurA_N_3; cl07813
591020001627	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
591020001628	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
591020001629	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
591020001630	active site
591020001631	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
591020001632	Ligand Binding Site [chemical binding]; other site
591020001633	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
591020001634	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
591020001635	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
591020001636	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
591020001637	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020001638	active site
591020001639	motif I; other site
591020001640	motif II; other site
591020001641	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591020001642	dimerization interface [polypeptide binding]; other site
591020001643	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
591020001644	putative DNA binding site [nucleotide binding]; other site
591020001645	putative Zn2+ binding site [ion binding]; other site
591020001646	AsnC family; Region: AsnC_trans_reg; pfam01037
591020001647	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591020001648	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
591020001649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020001650	Walker A/P-loop; other site
591020001651	ATP binding site [chemical binding]; other site
591020001652	Q-loop/lid; other site
591020001653	ABC transporter signature motif; other site
591020001654	Walker B; other site
591020001655	D-loop; other site
591020001656	H-loop/switch region; other site
591020001657	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
591020001658	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591020001659	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
591020001660	Walker A/P-loop; other site
591020001661	ATP binding site [chemical binding]; other site
591020001662	Q-loop/lid; other site
591020001663	ABC transporter signature motif; other site
591020001664	Walker B; other site
591020001665	D-loop; other site
591020001666	H-loop/switch region; other site
591020001667	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
591020001668	Nitrogen regulatory protein P-II; Region: P-II; smart00938
591020001669	ammonium transporter; Provisional; Region: PRK10666
591020001670	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
591020001671	catalytic triad [active]
591020001672	dimer interface [polypeptide binding]; other site
591020001673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
591020001674	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020001675	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020001676	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020001677	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
591020001678	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
591020001679	DNA binding site [nucleotide binding]
591020001680	active site
591020001681	Uncharacterized conserved protein [Function unknown]; Region: COG5507
591020001682	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
591020001683	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591020001684	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020001685	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
591020001686	gene expression modulator; Provisional; Region: PRK10945
591020001687	Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757
591020001688	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
591020001689	Protein export membrane protein; Region: SecD_SecF; cl14618
591020001690	Protein export membrane protein; Region: SecD_SecF; cl14618
591020001691	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
591020001692	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020001693	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020001694	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
591020001695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020001696	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
591020001697	hypothetical protein; Provisional; Region: PRK11281
591020001698	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
591020001699	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
591020001700	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591020001701	hypothetical protein; Provisional; Region: PRK11038
591020001702	primosomal replication protein N''; Provisional; Region: PRK10093
591020001703	hypothetical protein; Provisional; Region: PRK10527
591020001704	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020001705	active site
591020001706	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
591020001707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020001708	Walker A motif; other site
591020001709	ATP binding site [chemical binding]; other site
591020001710	Walker B motif; other site
591020001711	DNA polymerase III subunit delta'; Validated; Region: PRK08485
591020001712	arginine finger; other site
591020001713	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
591020001714	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
591020001715	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
591020001716	hypothetical protein; Validated; Region: PRK00153
591020001717	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353
591020001718	RecR protein; Region: RecR; pfam02132
591020001719	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
591020001720	putative active site [active]
591020001721	putative metal-binding site [ion binding]; other site
591020001722	tetramer interface [polypeptide binding]; other site
591020001723	heat shock protein 90; Provisional; Region: PRK05218
591020001724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020001725	ATP binding site [chemical binding]; other site
591020001726	Mg2+ binding site [ion binding]; other site
591020001727	G-X-G motif; other site
591020001728	adenylate kinase; Reviewed; Region: adk; PRK00279
591020001729	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
591020001730	AMP-binding site [chemical binding]; other site
591020001731	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
591020001732	ferrochelatase; Region: hemH; TIGR00109
591020001733	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
591020001734	C-terminal domain interface [polypeptide binding]; other site
591020001735	active site
591020001736	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
591020001737	active site
591020001738	N-terminal domain interface [polypeptide binding]; other site
591020001739	acetyl esterase; Provisional; Region: PRK10162
591020001740	inosine/guanosine kinase; Provisional; Region: PRK15074
591020001741	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020001742	putative cation:proton antiport protein; Provisional; Region: PRK10669
591020001743	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
591020001744	TrkA-N domain; Region: TrkA_N; pfam02254
591020001745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020001746	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020001747	putative substrate translocation pore; other site
591020001748	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
591020001749	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
591020001750	active site
591020001751	metal binding site [ion binding]; metal-binding site
591020001752	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591020001753	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
591020001754	putative deacylase active site [active]
591020001755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
591020001756	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
591020001757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020001758	non-specific DNA binding site [nucleotide binding]; other site
591020001759	salt bridge; other site
591020001760	sequence-specific DNA binding site [nucleotide binding]; other site
591020001761	copper exporting ATPase; Provisional; Region: copA; PRK10671
591020001762	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
591020001763	metal-binding site [ion binding]
591020001764	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
591020001765	metal-binding site [ion binding]
591020001766	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591020001767	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020001768	motif II; other site
591020001769	glutaminase; Reviewed; Region: PRK12356
591020001770	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
591020001771	amino acid transporter; Region: 2A0306; TIGR00909
591020001772	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
591020001773	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
591020001774	DNA binding residues [nucleotide binding]
591020001775	dimer interface [polypeptide binding]; other site
591020001776	copper binding site [ion binding]; other site
591020001777	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
591020001778	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
591020001779	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
591020001780	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
591020001781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020001782	Walker A/P-loop; other site
591020001783	ATP binding site [chemical binding]; other site
591020001784	Q-loop/lid; other site
591020001785	ABC transporter signature motif; other site
591020001786	Walker B; other site
591020001787	D-loop; other site
591020001788	H-loop/switch region; other site
591020001789	Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649
591020001790	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
591020001791	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
591020001792	oxidoreductase; Provisional; Region: PRK08017
591020001793	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
591020001794	NADP binding site [chemical binding]; other site
591020001795	active site
591020001796	steroid binding site; other site
591020001797	potential frameshift: common BLAST hit: gi|110640760|ref|YP_668488.1| multifunctional acyl-CoA thioesterase I/protease
591020001798	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
591020001799	catalytic triad [active]
591020001800	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
591020001801	oxyanion hole [active]
591020001802	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
591020001803	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591020001804	Walker A/P-loop; other site
591020001805	ATP binding site [chemical binding]; other site
591020001806	Q-loop/lid; other site
591020001807	ABC transporter signature motif; other site
591020001808	Walker B; other site
591020001809	D-loop; other site
591020001810	H-loop/switch region; other site
591020001811	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
591020001812	FtsX-like permease family; Region: FtsX; pfam02687
591020001813	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
591020001814	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
591020001815	active site residue [active]
591020001816	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
591020001817	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020001818	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020001819	dimerization interface [polypeptide binding]; other site
591020001820	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
591020001821	ureidoglycolate hydrolase; Provisional; Region: PRK03606
591020001822	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
591020001823	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591020001824	Bacterial transcriptional regulator; Region: IclR; pfam01614
591020001825	glyoxylate carboligase; Provisional; Region: PRK11269
591020001826	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591020001827	PYR/PP interface [polypeptide binding]; other site
591020001828	dimer interface [polypeptide binding]; other site
591020001829	TPP binding site [chemical binding]; other site
591020001830	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591020001831	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
591020001832	TPP-binding site [chemical binding]; other site
591020001833	hydroxypyruvate isomerase; Provisional; Region: PRK09997
591020001834	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001835	allantoate amidohydrolase; Region: AllC; TIGR03176
591020001836	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
591020001837	active site
591020001838	metal binding site [ion binding]; metal-binding site
591020001839	dimer interface [polypeptide binding]; other site
591020001840	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
591020001841	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
591020001842	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
591020001843	putative substrate binding site [chemical binding]; other site
591020001844	nucleotide binding site [chemical binding]; other site
591020001845	nucleotide binding site [chemical binding]; other site
591020001846	homodimer interface [polypeptide binding]; other site
591020001847	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
591020001848	ATP-grasp domain; Region: ATP-grasp; pfam02222
591020001849	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
591020001850	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
591020001851	putative active site [active]
591020001852	putative metal binding site [ion binding]; other site
591020001853	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
591020001854	substrate binding site [chemical binding]; other site
591020001855	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
591020001856	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
591020001857	active site
591020001858	HIGH motif; other site
591020001859	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
591020001860	KMSKS motif; other site
591020001861	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
591020001862	tRNA binding surface [nucleotide binding]; other site
591020001863	anticodon binding site; other site
591020001864	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
591020001865	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
591020001866	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
591020001867	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
591020001868	homodimer interface [polypeptide binding]; other site
591020001869	NADP binding site [chemical binding]; other site
591020001870	substrate binding site [chemical binding]; other site
591020001871	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
591020001872	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
591020001873	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591020001874	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591020001875	PapC N-terminal domain; Region: PapC_N; pfam13954
591020001876	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020001878	active site
591020001879	phosphorylation site [posttranslational modification]
591020001880	intermolecular recognition site; other site
591020001881	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
591020001882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020001883	hypothetical protein; Provisional; Region: PRK09936
591020001884	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
591020001885	active site
591020001886	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
591020001887	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
591020001888	sensor kinase CusS; Provisional; Region: PRK09835
591020001889	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020001890	dimerization interface [polypeptide binding]; other site
591020001891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020001892	dimer interface [polypeptide binding]; other site
591020001893	phosphorylation site [posttranslational modification]
591020001894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020001895	ATP binding site [chemical binding]; other site
591020001896	Mg2+ binding site [ion binding]; other site
591020001897	G-X-G motif; other site
591020001898	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
591020001899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020001900	active site
591020001901	phosphorylation site [posttranslational modification]
591020001902	intermolecular recognition site; other site
591020001903	dimerization interface [polypeptide binding]; other site
591020001904	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020001905	DNA binding site [nucleotide binding]
591020001906	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
591020001907	periplasmic copper-binding protein; Provisional; Region: PRK09838
591020001908	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
591020001909	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
591020001910	HTH-like domain; Region: HTH_21; pfam13276
591020001911	Integrase core domain; Region: rve; pfam00665
591020001912	Integrase core domain; Region: rve_3; pfam13683
591020001913	Transposase; Region: HTH_Tnp_1; cl17663
591020001914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020001915	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
591020001916	HTH-like domain; Region: HTH_21; pfam13276
591020001917	Integrase core domain; Region: rve; pfam00665
591020001918	Integrase core domain; Region: rve_3; pfam13683
591020001919	Transposase; Region: HTH_Tnp_1; cl17663
591020001920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020001921	potential protein location (hypothetical protein) that overlaps protein (IS2 ORF1)
591020001922	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020001923	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
591020001924	phenylalanine transporter; Provisional; Region: PRK10249
591020001925	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
591020001926	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591020001927	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
591020001928	dimer interface [polypeptide binding]; other site
591020001929	FMN binding site [chemical binding]; other site
591020001930	hypothetical protein; Provisional; Region: PRK10250
591020001931	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
591020001932	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
591020001933	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
591020001934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020001935	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020001936	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020001937	Hok/gef family; Region: HOK_GEF; pfam01848
591020001938	Hok/gef family; Region: HOK_GEF; pfam01848
591020001939	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
591020001940	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
591020001941	outer membrane receptor FepA; Provisional; Region: PRK13524
591020001942	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591020001943	N-terminal plug; other site
591020001944	ligand-binding site [chemical binding]; other site
591020001945	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
591020001946	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
591020001947	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
591020001948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
591020001949	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
591020001950	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
591020001951	acyl-activating enzyme (AAE) consensus motif; other site
591020001952	AMP binding site [chemical binding]; other site
591020001953	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591020001954	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020001955	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
591020001956	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591020001957	Walker A/P-loop; other site
591020001958	ATP binding site [chemical binding]; other site
591020001959	Q-loop/lid; other site
591020001960	ABC transporter signature motif; other site
591020001961	Walker B; other site
591020001962	D-loop; other site
591020001963	H-loop/switch region; other site
591020001964	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
591020001965	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020001966	ABC-ATPase subunit  interface; other site
591020001967	dimer interface [polypeptide binding]; other site
591020001968	putative PBP binding regions; other site
591020001969	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591020001970	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020001971	ABC-ATPase subunit  interface; other site
591020001972	dimer interface [polypeptide binding]; other site
591020001973	putative PBP binding regions; other site
591020001974	enterobactin exporter EntS; Provisional; Region: PRK10489
591020001975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020001976	putative substrate translocation pore; other site
591020001977	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
591020001978	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
591020001979	siderophore binding site; other site
591020001980	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
591020001981	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
591020001982	acyl-activating enzyme (AAE) consensus motif; other site
591020001983	active site
591020001984	AMP binding site [chemical binding]; other site
591020001985	substrate binding site [chemical binding]; other site
591020001986	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
591020001987	hydrophobic substrate binding pocket; other site
591020001988	Isochorismatase family; Region: Isochorismatase; pfam00857
591020001989	active site
591020001990	conserved cis-peptide bond; other site
591020001991	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
591020001992	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
591020001993	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
591020001994	putative NAD(P) binding site [chemical binding]; other site
591020001995	active site
591020001996	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
591020001997	CoenzymeA binding site [chemical binding]; other site
591020001998	subunit interaction site [polypeptide binding]; other site
591020001999	PHB binding site; other site
591020002000	carbon starvation protein A; Provisional; Region: PRK15015
591020002001	Carbon starvation protein CstA; Region: CstA; pfam02554
591020002002	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
591020002003	Uncharacterized small protein [Function unknown]; Region: COG2879
591020002004	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
591020002005	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
591020002006	putative active site [active]
591020002007	metal binding site [ion binding]; metal-binding site
591020002008	methionine aminotransferase; Validated; Region: PRK09082
591020002009	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591020002010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020002011	homodimer interface [polypeptide binding]; other site
591020002012	catalytic residue [active]
591020002013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020002014	Transposase; Region: HTH_Tnp_1; pfam01527
591020002015	putative transposase OrfB; Reviewed; Region: PHA02517
591020002016	HTH-like domain; Region: HTH_21; pfam13276
591020002017	Integrase core domain; Region: rve; pfam00665
591020002018	Integrase core domain; Region: rve_2; pfam13333
591020002019	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
591020002020	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020002021	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020002022	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
591020002023	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
591020002024	dimerization domain [polypeptide binding]; other site
591020002025	dimer interface [polypeptide binding]; other site
591020002026	catalytic residues [active]
591020002027	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
591020002028	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
591020002029	dimer interface [polypeptide binding]; other site
591020002030	decamer (pentamer of dimers) interface [polypeptide binding]; other site
591020002031	catalytic triad [active]
591020002032	peroxidatic and resolving cysteines [active]
591020002033	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
591020002034	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
591020002035	catalytic residue [active]
591020002036	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
591020002037	catalytic residues [active]
591020002038	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591020002039	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020002040	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591020002041	Ligand Binding Site [chemical binding]; other site
591020002042	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
591020002043	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591020002044	NAD binding site [chemical binding]; other site
591020002045	catalytic Zn binding site [ion binding]; other site
591020002046	structural Zn binding site [ion binding]; other site
591020002047	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
591020002048	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
591020002049	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
591020002050	B1 nucleotide binding pocket [chemical binding]; other site
591020002051	B2 nucleotide binding pocket [chemical binding]; other site
591020002052	CAS motifs; other site
591020002053	active site
591020002054	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
591020002055	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
591020002056	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
591020002057	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
591020002058	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
591020002059	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
591020002060	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
591020002061	putative active site [active]
591020002062	(T/H)XGH motif; other site
591020002063	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020002064	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
591020002065	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
591020002066	dimer interface [polypeptide binding]; other site
591020002067	active site
591020002068	Int/Topo IB signature motif; other site
591020002069	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
591020002070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020002071	motif II; other site
591020002072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020002073	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
591020002074	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020002075	Walker A/P-loop; other site
591020002076	ATP binding site [chemical binding]; other site
591020002077	Q-loop/lid; other site
591020002078	ABC transporter signature motif; other site
591020002079	Walker B; other site
591020002080	D-loop; other site
591020002081	H-loop/switch region; other site
591020002082	molybdenum-pterin binding domain; Region: Mop; TIGR00638
591020002083	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
591020002084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002085	putative PBP binding loops; other site
591020002086	ABC-ATPase subunit interface; other site
591020002087	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
591020002088	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020002089	substrate binding pocket [chemical binding]; other site
591020002090	membrane-bound complex binding site; other site
591020002091	hinge residues; other site
591020002092	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
591020002093	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
591020002094	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
591020002095	molybdenum-pterin binding domain; Region: Mop; TIGR00638
591020002096	TOBE domain; Region: TOBE; pfam03459
591020002097	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
591020002098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
591020002099	Walker A/P-loop; other site
591020002100	ATP binding site [chemical binding]; other site
591020002101	Q-loop/lid; other site
591020002102	ABC transporter signature motif; other site
591020002103	Walker B; other site
591020002104	D-loop; other site
591020002105	H-loop/switch region; other site
591020002106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020002107	Walker A/P-loop; other site
591020002108	ATP binding site [chemical binding]; other site
591020002109	Q-loop/lid; other site
591020002110	ABC transporter signature motif; other site
591020002111	Walker B; other site
591020002112	D-loop; other site
591020002113	H-loop/switch region; other site
591020002114	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
591020002115	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
591020002116	NAD binding site [chemical binding]; other site
591020002117	homodimer interface [polypeptide binding]; other site
591020002118	active site
591020002119	substrate binding site [chemical binding]; other site
591020002120	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
591020002121	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
591020002122	dimer interface [polypeptide binding]; other site
591020002123	active site
591020002124	galactokinase; Provisional; Region: PRK05101
591020002125	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
591020002126	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591020002127	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
591020002128	active site
591020002129	catalytic residues [active]
591020002130	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591020002131	catalytic core [active]
591020002132	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591020002133	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
591020002134	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591020002135	YbgS-like protein; Region: YbgS; pfam13985
591020002136	zinc transporter ZitB; Provisional; Region: PRK03557
591020002137	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
591020002138	quinolinate synthetase; Provisional; Region: PRK09375
591020002139	tol-pal system protein YbgF; Provisional; Region: PRK10803
591020002140	Tetratricopeptide repeat; Region: TPR_6; pfam13174
591020002141	Tetratricopeptide repeat; Region: TPR_6; pfam13174
591020002142	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
591020002143	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591020002144	ligand binding site [chemical binding]; other site
591020002145	translocation protein TolB; Provisional; Region: tolB; PRK03629
591020002146	TolB amino-terminal domain; Region: TolB_N; pfam04052
591020002147	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
591020002148	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
591020002149	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
591020002150	TolA C-terminal; Region: TolA; pfam06519
591020002151	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
591020002152	colicin uptake protein TolR; Provisional; Region: PRK11024
591020002153	colicin uptake protein TolQ; Provisional; Region: PRK10801
591020002154	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
591020002155	active site
591020002156	hypothetical protein; Provisional; Region: PRK10588
591020002157	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
591020002158	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
591020002159	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
591020002160	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
591020002161	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
591020002162	alpha-mannosidase; Provisional; Region: PRK09819
591020002163	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
591020002164	active site
591020002165	metal binding site [ion binding]; metal-binding site
591020002166	catalytic site [active]
591020002167	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
591020002168	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
591020002169	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020002170	active site
591020002171	phosphorylation site [posttranslational modification]
591020002172	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591020002173	active site
591020002174	P-loop; other site
591020002175	phosphorylation site [posttranslational modification]
591020002176	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
591020002177	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
591020002178	CoA binding domain; Region: CoA_binding; smart00881
591020002179	CoA-ligase; Region: Ligase_CoA; pfam00549
591020002180	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
591020002181	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
591020002182	CoA-ligase; Region: Ligase_CoA; pfam00549
591020002183	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
591020002184	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
591020002185	E3 interaction surface; other site
591020002186	lipoyl attachment site [posttranslational modification]; other site
591020002187	e3 binding domain; Region: E3_binding; pfam02817
591020002188	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
591020002189	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
591020002190	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
591020002191	TPP-binding site [chemical binding]; other site
591020002192	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
591020002193	dimer interface [polypeptide binding]; other site
591020002194	PYR/PP interface [polypeptide binding]; other site
591020002195	TPP binding site [chemical binding]; other site
591020002196	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
591020002197	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
591020002198	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
591020002199	L-aspartate oxidase; Provisional; Region: PRK06175
591020002200	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
591020002201	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
591020002202	SdhC subunit interface [polypeptide binding]; other site
591020002203	proximal heme binding site [chemical binding]; other site
591020002204	cardiolipin binding site; other site
591020002205	Iron-sulfur protein interface; other site
591020002206	proximal quinone binding site [chemical binding]; other site
591020002207	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
591020002208	Iron-sulfur protein interface; other site
591020002209	proximal quinone binding site [chemical binding]; other site
591020002210	SdhD (CybS) interface [polypeptide binding]; other site
591020002211	proximal heme binding site [chemical binding]; other site
591020002212	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
591020002213	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
591020002214	dimer interface [polypeptide binding]; other site
591020002215	active site
591020002216	citrylCoA binding site [chemical binding]; other site
591020002217	NADH binding [chemical binding]; other site
591020002218	cationic pore residues; other site
591020002219	oxalacetate/citrate binding site [chemical binding]; other site
591020002220	coenzyme A binding site [chemical binding]; other site
591020002221	catalytic triad [active]
591020002222	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591020002223	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
591020002224	PapC N-terminal domain; Region: PapC_N; pfam13954
591020002225	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020002226	PapC C-terminal domain; Region: PapC_C; pfam13953
591020002227	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
591020002228	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591020002229	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591020002230	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
591020002231	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
591020002232	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
591020002233	endonuclease VIII; Provisional; Region: PRK10445
591020002234	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
591020002235	DNA binding site [nucleotide binding]
591020002236	catalytic residue [active]
591020002237	putative catalytic residues [active]
591020002238	H2TH interface [polypeptide binding]; other site
591020002239	intercalation triad [nucleotide binding]; other site
591020002240	substrate specificity determining residue; other site
591020002241	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
591020002242	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591020002243	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
591020002244	putative active site [active]
591020002245	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
591020002246	sensor histidine kinase inhibitor, KipI family; Region: TIGR00370
591020002247	Uncharacterized conserved protein [Function unknown]; Region: COG0327
591020002248	metal-binding protein; Provisional; Region: PRK10799
591020002249	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
591020002250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020002251	putative substrate translocation pore; other site
591020002252	POT family; Region: PTR2; pfam00854
591020002253	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
591020002254	DNA photolyase; Region: DNA_photolyase; pfam00875
591020002255	hypothetical protein; Provisional; Region: PRK10167
591020002256	Uncharacterized conserved protein [Function unknown]; Region: COG3272
591020002257	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
591020002258	PAAR motif; Region: PAAR_motif; pfam05488
591020002259	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
591020002260	RHS Repeat; Region: RHS_repeat; cl11982
591020002261	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
591020002262	RHS Repeat; Region: RHS_repeat; cl11982
591020002263	RHS Repeat; Region: RHS_repeat; pfam05593
591020002264	RHS Repeat; Region: RHS_repeat; cl11982
591020002265	RHS protein; Region: RHS; pfam03527
591020002266	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
591020002267	Domain of unknown function (DUF1795); Region: DUF1795; cl02256
591020002268	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020002269	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
591020002270	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
591020002271	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
591020002272	putrescine transporter; Provisional; Region: potE; PRK10655
591020002273	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
591020002274	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
591020002275	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
591020002276	active site
591020002277	substrate binding site [chemical binding]; other site
591020002278	metal binding site [ion binding]; metal-binding site
591020002279	replication initiation regulator SeqA; Provisional; Region: PRK11187
591020002280	acyl-CoA esterase; Provisional; Region: PRK10673
591020002281	PGAP1-like protein; Region: PGAP1; pfam07819
591020002282	LexA regulated protein; Provisional; Region: PRK11675
591020002283	flavodoxin FldA; Validated; Region: PRK09267
591020002284	ferric uptake regulator; Provisional; Region: fur; PRK09462
591020002285	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
591020002286	metal binding site 2 [ion binding]; metal-binding site
591020002287	putative DNA binding helix; other site
591020002288	metal binding site 1 [ion binding]; metal-binding site
591020002289	dimer interface [polypeptide binding]; other site
591020002290	structural Zn2+ binding site [ion binding]; other site
591020002291	YbfN-like lipoprotein; Region: YbfN; pfam13982
591020002292	outer membrane porin, OprD family; Region: OprD; pfam03573
591020002293	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
591020002294	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591020002295	active site
591020002296	HIGH motif; other site
591020002297	nucleotide binding site [chemical binding]; other site
591020002298	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
591020002299	KMSKS motif; other site
591020002300	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
591020002301	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
591020002302	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591020002303	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591020002304	active site turn [active]
591020002305	phosphorylation site [posttranslational modification]
591020002306	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
591020002307	HPr interaction site; other site
591020002308	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591020002309	active site
591020002310	phosphorylation site [posttranslational modification]
591020002311	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
591020002312	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
591020002313	active site
591020002314	trimer interface [polypeptide binding]; other site
591020002315	allosteric site; other site
591020002316	active site lid [active]
591020002317	hexamer (dimer of trimers) interface [polypeptide binding]; other site
591020002318	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
591020002319	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
591020002320	active site
591020002321	dimer interface [polypeptide binding]; other site
591020002322	MarR family; Region: MarR; pfam01047
591020002323	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591020002324	ROK family; Region: ROK; pfam00480
591020002325	asparagine synthetase B; Provisional; Region: asnB; PRK09431
591020002326	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
591020002327	active site
591020002328	dimer interface [polypeptide binding]; other site
591020002329	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
591020002330	Ligand Binding Site [chemical binding]; other site
591020002331	Molecular Tunnel; other site
591020002332	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
591020002333	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
591020002334	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
591020002335	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
591020002336	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020002337	FeS/SAM binding site; other site
591020002338	TRAM domain; Region: TRAM; pfam01938
591020002339	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
591020002340	PhoH-like protein; Region: PhoH; pfam02562
591020002341	metal-binding heat shock protein; Provisional; Region: PRK00016
591020002342	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
591020002343	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591020002344	Transporter associated domain; Region: CorC_HlyC; smart01091
591020002345	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
591020002346	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
591020002347	putative active site [active]
591020002348	catalytic triad [active]
591020002349	putative dimer interface [polypeptide binding]; other site
591020002350	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
591020002351	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020002352	substrate binding pocket [chemical binding]; other site
591020002353	membrane-bound complex binding site; other site
591020002354	hinge residues; other site
591020002355	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591020002356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002357	dimer interface [polypeptide binding]; other site
591020002358	conserved gate region; other site
591020002359	putative PBP binding loops; other site
591020002360	ABC-ATPase subunit interface; other site
591020002361	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591020002362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002363	dimer interface [polypeptide binding]; other site
591020002364	conserved gate region; other site
591020002365	putative PBP binding loops; other site
591020002366	ABC-ATPase subunit interface; other site
591020002367	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
591020002368	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591020002369	Walker A/P-loop; other site
591020002370	ATP binding site [chemical binding]; other site
591020002371	Q-loop/lid; other site
591020002372	ABC transporter signature motif; other site
591020002373	Walker B; other site
591020002374	D-loop; other site
591020002375	H-loop/switch region; other site
591020002376	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
591020002377	active site
591020002378	tetramer interface [polypeptide binding]; other site
591020002379	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
591020002380	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
591020002381	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
591020002382	Sel1-like repeats; Region: SEL1; smart00671
591020002383	Sel1-like repeats; Region: SEL1; smart00671
591020002384	Sel1-like repeats; Region: SEL1; smart00671
591020002385	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
591020002386	HSP70 interaction site [polypeptide binding]; other site
591020002387	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
591020002388	Sel1-like repeats; Region: SEL1; smart00671
591020002389	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
591020002390	Sel1-like repeats; Region: SEL1; smart00671
591020002391	Sel1-like repeats; Region: SEL1; smart00671
591020002392	Sel1-like repeats; Region: SEL1; smart00671
591020002393	Sel1-like repeats; Region: SEL1; smart00671
591020002394	Sel1-like repeats; Region: SEL1; smart00671
591020002395	Sel1-like repeats; Region: SEL1; smart00671
591020002396	hypothetical protein; Provisional; Region: PRK11032
591020002397	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
591020002398	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
591020002399	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
591020002400	HIGH motif; other site
591020002401	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
591020002402	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
591020002403	active site
591020002404	KMSKS motif; other site
591020002405	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
591020002406	tRNA binding surface [nucleotide binding]; other site
591020002407	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
591020002408	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
591020002409	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
591020002410	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
591020002411	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
591020002412	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
591020002413	active site
591020002414	(T/H)XGH motif; other site
591020002415	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591020002416	catalytic core [active]
591020002417	ribosome-associated protein; Provisional; Region: PRK11538
591020002418	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
591020002419	penicillin-binding protein 2; Provisional; Region: PRK10795
591020002420	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
591020002421	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
591020002422	cell wall shape-determining protein; Provisional; Region: PRK10794
591020002423	rare lipoprotein A; Provisional; Region: PRK10672
591020002424	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
591020002425	Sporulation related domain; Region: SPOR; pfam05036
591020002426	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
591020002427	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
591020002428	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
591020002429	hypothetical protein; Provisional; Region: PRK04998
591020002430	lipoate-protein ligase B; Provisional; Region: PRK14342
591020002431	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
591020002432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020002433	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
591020002434	substrate binding pocket [chemical binding]; other site
591020002435	dimerization interface [polypeptide binding]; other site
591020002436	lipoyl synthase; Provisional; Region: PRK05481
591020002437	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020002438	FeS/SAM binding site; other site
591020002439	Predicted amidohydrolase [General function prediction only]; Region: COG0388
591020002440	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
591020002441	putative active site [active]
591020002442	catalytic triad [active]
591020002443	putative dimer interface [polypeptide binding]; other site
591020002444	chromosome condensation membrane protein; Provisional; Region: PRK14196
591020002445	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591020002446	DNA-binding site [nucleotide binding]; DNA binding site
591020002447	RNA-binding motif; other site
591020002448	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
591020002449	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
591020002450	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
591020002451	Transcriptional regulator; Region: CitT; pfam12431
591020002452	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
591020002453	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
591020002454	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
591020002455	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
591020002456	Bacteriophage Mu transposase; Region: DDE_2; pfam02914
591020002457	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
591020002458	putative transposase OrfB; Reviewed; Region: PHA02517
591020002459	HTH-like domain; Region: HTH_21; pfam13276
591020002460	Integrase core domain; Region: rve; pfam00665
591020002461	Integrase core domain; Region: rve_3; pfam13683
591020002462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
591020002463	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
591020002464	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
591020002465	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
591020002466	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
591020002467	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
591020002468	Chromosome condensation complex Condensin, subunit H [Chromatin structure and dynamics / Cell division and chromosome partitioning]; Region: LOC7; COG5229
591020002469	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020002470	HTH-like domain; Region: HTH_21; pfam13276
591020002471	Integrase core domain; Region: rve; pfam00665
591020002472	Integrase core domain; Region: rve_3; pfam13683
591020002473	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020002474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020002475	Phage terminase large subunit; Region: Terminase_3; cl12054
591020002476	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591020002477	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591020002478	Lipoprotein Rz1 precursor; Region: Rz1; pfam06085
591020002479	Integrase core domain; Region: rve; pfam00665
591020002480	Integrase core domain; Region: rve_3; pfam13683
591020002481	Protein of unknown function (DUF1133); Region: DUF1133; pfam06576
591020002482	Lysis protein S; Region: Lysis_S; pfam04971
591020002483	putative transposase OrfB; Reviewed; Region: PHA02517
591020002484	Integrase core domain; Region: rve; pfam00665
591020002485	Integrase core domain; Region: rve_3; pfam13683
591020002486	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
591020002487	active site
591020002488	metal binding site [ion binding]; metal-binding site
591020002489	interdomain interaction site; other site
591020002490	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
591020002491	putative transposase OrfB; Reviewed; Region: PHA02517
591020002492	HTH-like domain; Region: HTH_21; pfam13276
591020002493	Integrase core domain; Region: rve; pfam00665
591020002494	Integrase core domain; Region: rve_3; pfam13683
591020002495	replicative DNA helicase; Region: DnaB; TIGR00665
591020002496	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
591020002497	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
591020002498	Walker A motif; other site
591020002499	ATP binding site [chemical binding]; other site
591020002500	Walker B motif; other site
591020002501	DNA binding loops [nucleotide binding]
591020002502	Phage NinH protein; Region: Phage_NinH; pfam06322
591020002503	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
591020002504	Lysis protein S; Region: Lysis_S; pfam04971
591020002505	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
591020002506	catalytic residues [active]
591020002507	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
591020002508	putative transposase OrfB; Reviewed; Region: PHA02517
591020002509	HTH-like domain; Region: HTH_21; pfam13276
591020002510	Integrase core domain; Region: rve; pfam00665
591020002511	Integrase core domain; Region: rve_3; pfam13683
591020002512	Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220
591020002513	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
591020002514	gpW; Region: gpW; pfam02831
591020002515	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
591020002516	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
591020002517	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
591020002518	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
591020002519	tandem repeat interface [polypeptide binding]; other site
591020002520	oligomer interface [polypeptide binding]; other site
591020002521	active site residues [active]
591020002522	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
591020002523	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
591020002524	DNA packaging protein FI; Region: Packaging_FI; pfam14000
591020002525	Phage Head-Tail Attachment; Region: Phage_attach; pfam05354
591020002526	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
591020002527	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
591020002528	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
591020002529	Bacterial Ig-like domain 2; Region: BID_2; smart00635
591020002530	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106
591020002531	Minor tail protein T; Region: Phage_tail_T; pfam06223
591020002532	Phage-related protein [Function unknown]; Region: gp18; COG4672
591020002533	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
591020002534	MPN+ (JAMM) motif; other site
591020002535	Zinc-binding site [ion binding]; other site
591020002536	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591020002537	NlpC/P60 family; Region: NLPC_P60; cl17555
591020002538	Phage-related protein, tail component [Function unknown]; Region: COG4723
591020002539	Phage-related protein, tail component [Function unknown]; Region: COG4733
591020002540	Putative phage tail protein; Region: Phage-tail_3; pfam13550
591020002541	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
591020002542	Interdomain contacts; other site
591020002543	Cytokine receptor motif; other site
591020002544	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
591020002545	Fibronectin type III protein; Region: DUF3672; pfam12421
591020002546	Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316
591020002547	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
591020002548	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020002549	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
591020002550	Transposase, Mutator family; Region: Transposase_mut; pfam00872
591020002551	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
591020002552	substrate binding site [chemical binding]; other site
591020002553	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
591020002554	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591020002555	inhibitor-cofactor binding pocket; inhibition site
591020002556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020002557	catalytic residue [active]
591020002558	biotin synthase; Provisional; Region: PRK15108
591020002559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020002560	FeS/SAM binding site; other site
591020002561	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
591020002562	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
591020002563	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
591020002564	substrate-cofactor binding pocket; other site
591020002565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020002566	catalytic residue [active]
591020002567	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
591020002568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020002569	S-adenosylmethionine binding site [chemical binding]; other site
591020002570	AAA domain; Region: AAA_26; pfam13500
591020002571	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591020002572	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
591020002573	ADP binding site [chemical binding]; other site
591020002574	excinuclease ABC subunit B; Provisional; Region: PRK05298
591020002575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020002576	ATP binding site [chemical binding]; other site
591020002577	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020002578	nucleotide binding region [chemical binding]; other site
591020002579	ATP-binding site [chemical binding]; other site
591020002580	Ultra-violet resistance protein B; Region: UvrB; pfam12344
591020002581	UvrB/uvrC motif; Region: UVR; pfam02151
591020002582	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
591020002583	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
591020002584	putative substrate binding pocket [chemical binding]; other site
591020002585	dimer interface [polypeptide binding]; other site
591020002586	phosphate binding site [ion binding]; other site
591020002587	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
591020002588	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020002589	FeS/SAM binding site; other site
591020002590	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
591020002591	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
591020002592	MPT binding site; other site
591020002593	trimer interface [polypeptide binding]; other site
591020002594	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
591020002595	trimer interface [polypeptide binding]; other site
591020002596	dimer interface [polypeptide binding]; other site
591020002597	putative active site [active]
591020002598	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
591020002599	MoaE interaction surface [polypeptide binding]; other site
591020002600	MoeB interaction surface [polypeptide binding]; other site
591020002601	thiocarboxylated glycine; other site
591020002602	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
591020002603	MoaE homodimer interface [polypeptide binding]; other site
591020002604	MoaD interaction [polypeptide binding]; other site
591020002605	active site residues [active]
591020002606	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
591020002607	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
591020002608	Predicted integral membrane protein [Function unknown]; Region: COG0392
591020002609	cardiolipin synthase 2; Provisional; Region: PRK11263
591020002610	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
591020002611	putative active site [active]
591020002612	catalytic site [active]
591020002613	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
591020002614	putative active site [active]
591020002615	catalytic site [active]
591020002616	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
591020002617	putative catalytic site [active]
591020002618	putative metal binding site [ion binding]; other site
591020002619	putative phosphate binding site [ion binding]; other site
591020002620	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
591020002621	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591020002622	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
591020002623	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591020002624	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
591020002625	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
591020002626	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591020002627	Walker A/P-loop; other site
591020002628	ATP binding site [chemical binding]; other site
591020002629	Q-loop/lid; other site
591020002630	ABC transporter signature motif; other site
591020002631	Walker B; other site
591020002632	D-loop; other site
591020002633	H-loop/switch region; other site
591020002634	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
591020002635	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591020002636	Walker A/P-loop; other site
591020002637	ATP binding site [chemical binding]; other site
591020002638	Q-loop/lid; other site
591020002639	ABC transporter signature motif; other site
591020002640	Walker B; other site
591020002641	D-loop; other site
591020002642	H-loop/switch region; other site
591020002643	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
591020002644	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020002645	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
591020002646	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
591020002647	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591020002648	ATP binding site [chemical binding]; other site
591020002649	Mg++ binding site [ion binding]; other site
591020002650	motif III; other site
591020002651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020002652	nucleotide binding region [chemical binding]; other site
591020002653	ATP-binding site [chemical binding]; other site
591020002654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
591020002655	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
591020002656	DEAD_2; Region: DEAD_2; pfam06733
591020002657	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
591020002658	glycosyl transferase family protein; Provisional; Region: PRK08136
591020002659	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
591020002660	putative dehydrogenase; Provisional; Region: PRK10098
591020002661	hypothetical protein; Provisional; Region: PRK10259
591020002662	hypothetical protein; Provisional; Region: PRK11019
591020002663	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
591020002664	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020002665	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020002666	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020002667	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
591020002668	hypothetical protein; Provisional; Region: PRK10259
591020002669	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
591020002670	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
591020002671	putative mechanosensitive channel protein; Provisional; Region: PRK11465
591020002672	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591020002673	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
591020002674	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591020002675	Walker A/P-loop; other site
591020002676	ATP binding site [chemical binding]; other site
591020002677	Q-loop/lid; other site
591020002678	ABC transporter signature motif; other site
591020002679	Walker B; other site
591020002680	D-loop; other site
591020002681	H-loop/switch region; other site
591020002682	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591020002683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002684	dimer interface [polypeptide binding]; other site
591020002685	conserved gate region; other site
591020002686	putative PBP binding loops; other site
591020002687	ABC-ATPase subunit interface; other site
591020002688	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
591020002689	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020002690	substrate binding pocket [chemical binding]; other site
591020002691	membrane-bound complex binding site; other site
591020002692	hinge residues; other site
591020002693	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
591020002694	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
591020002695	dimerization interface [polypeptide binding]; other site
591020002696	DPS ferroxidase diiron center [ion binding]; other site
591020002697	ion pore; other site
591020002698	threonine and homoserine efflux system; Provisional; Region: PRK10532
591020002699	EamA-like transporter family; Region: EamA; pfam00892
591020002700	outer membrane protein X; Provisional; Region: ompX; PRK09408
591020002701	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
591020002702	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
591020002703	Sulfatase; Region: Sulfatase; pfam00884
591020002704	manganese transport regulator MntR; Provisional; Region: PRK11050
591020002705	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
591020002706	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
591020002707	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591020002708	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
591020002709	transmembrane helices; other site
591020002710	L,D-transpeptidase; Provisional; Region: PRK10260
591020002711	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591020002712	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
591020002713	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020002714	Walker A/P-loop; other site
591020002715	ATP binding site [chemical binding]; other site
591020002716	Q-loop/lid; other site
591020002717	ABC transporter signature motif; other site
591020002718	Walker B; other site
591020002719	D-loop; other site
591020002720	H-loop/switch region; other site
591020002721	ABC transporter; Region: ABC_tran_2; pfam12848
591020002722	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591020002723	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
591020002724	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
591020002725	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020002726	active site
591020002727	motif I; other site
591020002728	motif II; other site
591020002729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020002730	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
591020002731	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
591020002732	dimer interface [polypeptide binding]; other site
591020002733	active site
591020002734	glycine loop; other site
591020002735	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
591020002736	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
591020002737	active site
591020002738	intersubunit interactions; other site
591020002739	catalytic residue [active]
591020002740	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
591020002741	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
591020002742	ATP binding site [chemical binding]; other site
591020002743	substrate interface [chemical binding]; other site
591020002744	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
591020002745	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
591020002746	dimer interface [polypeptide binding]; other site
591020002747	putative functional site; other site
591020002748	putative MPT binding site; other site
591020002749	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
591020002750	catalytic nucleophile [active]
591020002751	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
591020002752	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020002753	Walker A/P-loop; other site
591020002754	ATP binding site [chemical binding]; other site
591020002755	Q-loop/lid; other site
591020002756	ABC transporter signature motif; other site
591020002757	Walker B; other site
591020002758	D-loop; other site
591020002759	H-loop/switch region; other site
591020002760	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591020002761	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020002762	Walker A/P-loop; other site
591020002763	ATP binding site [chemical binding]; other site
591020002764	Q-loop/lid; other site
591020002765	ABC transporter signature motif; other site
591020002766	Walker B; other site
591020002767	D-loop; other site
591020002768	H-loop/switch region; other site
591020002769	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591020002770	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
591020002771	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
591020002772	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
591020002773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002774	dimer interface [polypeptide binding]; other site
591020002775	conserved gate region; other site
591020002776	putative PBP binding loops; other site
591020002777	ABC-ATPase subunit interface; other site
591020002778	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
591020002779	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591020002780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002781	dimer interface [polypeptide binding]; other site
591020002782	conserved gate region; other site
591020002783	putative PBP binding loops; other site
591020002784	ABC-ATPase subunit interface; other site
591020002785	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591020002786	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020002787	metal binding site [ion binding]; metal-binding site
591020002788	active site
591020002789	I-site; other site
591020002790	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
591020002791	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
591020002792	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020002793	FeS/SAM binding site; other site
591020002794	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
591020002795	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
591020002796	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
591020002797	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
591020002798	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
591020002799	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
591020002800	N-terminal domain interface [polypeptide binding]; other site
591020002801	dimer interface [polypeptide binding]; other site
591020002802	substrate binding pocket (H-site) [chemical binding]; other site
591020002803	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
591020002804	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591020002805	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020002806	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
591020002807	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591020002808	active site
591020002809	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
591020002810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020002811	putative substrate translocation pore; other site
591020002812	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
591020002813	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020002814	active site
591020002815	motif I; other site
591020002816	motif II; other site
591020002817	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020002818	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591020002819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020002820	putative substrate translocation pore; other site
591020002821	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020002822	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
591020002823	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020002824	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
591020002825	putative transporter; Provisional; Region: PRK04972
591020002826	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
591020002827	TrkA-C domain; Region: TrkA_C; pfam02080
591020002828	TrkA-C domain; Region: TrkA_C; pfam02080
591020002829	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
591020002830	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
591020002831	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
591020002832	GSH binding site [chemical binding]; other site
591020002833	catalytic residues [active]
591020002834	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
591020002835	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
591020002836	dimer interface [polypeptide binding]; other site
591020002837	FMN binding site [chemical binding]; other site
591020002838	NADPH bind site [chemical binding]; other site
591020002839	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
591020002840	RimK-like ATP-grasp domain; Region: RimK; pfam08443
591020002841	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
591020002842	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
591020002843	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
591020002844	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
591020002845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020002846	Walker A/P-loop; other site
591020002847	ATP binding site [chemical binding]; other site
591020002848	Q-loop/lid; other site
591020002849	ABC transporter signature motif; other site
591020002850	Walker B; other site
591020002851	D-loop; other site
591020002852	H-loop/switch region; other site
591020002853	TOBE domain; Region: TOBE_2; pfam08402
591020002854	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
591020002855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002856	dimer interface [polypeptide binding]; other site
591020002857	conserved gate region; other site
591020002858	putative PBP binding loops; other site
591020002859	ABC-ATPase subunit interface; other site
591020002860	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591020002861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002862	dimer interface [polypeptide binding]; other site
591020002863	conserved gate region; other site
591020002864	putative PBP binding loops; other site
591020002865	ABC-ATPase subunit interface; other site
591020002866	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
591020002867	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
591020002868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020002869	S-adenosylmethionine binding site [chemical binding]; other site
591020002870	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
591020002871	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020002872	substrate binding pocket [chemical binding]; other site
591020002873	membrane-bound complex binding site; other site
591020002874	hinge residues; other site
591020002875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002876	dimer interface [polypeptide binding]; other site
591020002877	conserved gate region; other site
591020002878	putative PBP binding loops; other site
591020002879	ABC-ATPase subunit interface; other site
591020002880	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591020002881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020002882	dimer interface [polypeptide binding]; other site
591020002883	conserved gate region; other site
591020002884	putative PBP binding loops; other site
591020002885	ABC-ATPase subunit interface; other site
591020002886	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
591020002887	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020002888	substrate binding pocket [chemical binding]; other site
591020002889	membrane-bound complex binding site; other site
591020002890	hinge residues; other site
591020002891	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
591020002892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020002893	Walker A/P-loop; other site
591020002894	ATP binding site [chemical binding]; other site
591020002895	Q-loop/lid; other site
591020002896	ABC transporter signature motif; other site
591020002897	Walker B; other site
591020002898	D-loop; other site
591020002899	H-loop/switch region; other site
591020002900	putative lipoprotein; Provisional; Region: PRK10533
591020002901	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
591020002902	hypothetical protein; Provisional; Region: PRK02877
591020002903	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
591020002904	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
591020002905	amidase catalytic site [active]
591020002906	Zn binding residues [ion binding]; other site
591020002907	substrate binding site [chemical binding]; other site
591020002908	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591020002909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591020002910	NAD(P) binding site [chemical binding]; other site
591020002911	active site
591020002912	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
591020002913	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
591020002914	putative NAD(P) binding site [chemical binding]; other site
591020002915	putative active site [active]
591020002916	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
591020002917	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
591020002918	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
591020002919	tetramer interface [polypeptide binding]; other site
591020002920	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020002921	catalytic residue [active]
591020002922	pyruvate dehydrogenase; Provisional; Region: PRK09124
591020002923	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
591020002924	PYR/PP interface [polypeptide binding]; other site
591020002925	dimer interface [polypeptide binding]; other site
591020002926	tetramer interface [polypeptide binding]; other site
591020002927	TPP binding site [chemical binding]; other site
591020002928	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591020002929	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
591020002930	TPP-binding site [chemical binding]; other site
591020002931	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
591020002932	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
591020002933	FAD binding pocket [chemical binding]; other site
591020002934	FAD binding motif [chemical binding]; other site
591020002935	phosphate binding motif [ion binding]; other site
591020002936	beta-alpha-beta structure motif; other site
591020002937	NAD binding pocket [chemical binding]; other site
591020002938	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591020002939	catalytic loop [active]
591020002940	iron binding site [ion binding]; other site
591020002941	hybrid cluster protein; Provisional; Region: PRK05290
591020002942	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591020002943	ACS interaction site; other site
591020002944	CODH interaction site; other site
591020002945	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
591020002946	hybrid metal cluster; other site
591020002947	Predicted membrane protein [Function unknown]; Region: COG2431
591020002948	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020002949	HTH-like domain; Region: HTH_21; pfam13276
591020002950	Integrase core domain; Region: rve; pfam00665
591020002951	Integrase core domain; Region: rve_3; pfam13683
591020002952	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020002953	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020002954	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
591020002955	amphipathic channel; other site
591020002956	Asn-Pro-Ala signature motifs; other site
591020002957	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
591020002958	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
591020002959	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
591020002960	putative active site [active]
591020002961	putative metal-binding site [ion binding]; other site
591020002962	Protein of unknown function (DUF535); Region: DUF535; pfam04393
591020002963	macrolide transporter subunit MacA; Provisional; Region: PRK11578
591020002964	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020002965	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020002966	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
591020002967	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591020002968	Walker A/P-loop; other site
591020002969	ATP binding site [chemical binding]; other site
591020002970	Q-loop/lid; other site
591020002971	ABC transporter signature motif; other site
591020002972	Walker B; other site
591020002973	D-loop; other site
591020002974	H-loop/switch region; other site
591020002975	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
591020002976	FtsX-like permease family; Region: FtsX; pfam02687
591020002977	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591020002978	DNA-binding site [nucleotide binding]; DNA binding site
591020002979	RNA-binding motif; other site
591020002980	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
591020002981	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
591020002982	Clp amino terminal domain; Region: Clp_N; pfam02861
591020002983	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020002984	Walker A motif; other site
591020002985	ATP binding site [chemical binding]; other site
591020002986	Walker B motif; other site
591020002987	arginine finger; other site
591020002988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020002989	Walker A motif; other site
591020002990	ATP binding site [chemical binding]; other site
591020002991	Walker B motif; other site
591020002992	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591020002993	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
591020002994	rRNA binding site [nucleotide binding]; other site
591020002995	predicted 30S ribosome binding site; other site
591020002996	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
591020002997	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
591020002998	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591020002999	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
591020003000	Walker A/P-loop; other site
591020003001	ATP binding site [chemical binding]; other site
591020003002	Q-loop/lid; other site
591020003003	ABC transporter signature motif; other site
591020003004	Walker B; other site
591020003005	D-loop; other site
591020003006	H-loop/switch region; other site
591020003007	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
591020003008	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591020003009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020003010	Walker A/P-loop; other site
591020003011	ATP binding site [chemical binding]; other site
591020003012	Q-loop/lid; other site
591020003013	ABC transporter signature motif; other site
591020003014	Walker B; other site
591020003015	D-loop; other site
591020003016	H-loop/switch region; other site
591020003017	thioredoxin reductase; Provisional; Region: PRK10262
591020003018	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591020003019	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020003020	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
591020003021	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591020003022	putative DNA binding site [nucleotide binding]; other site
591020003023	putative Zn2+ binding site [ion binding]; other site
591020003024	AsnC family; Region: AsnC_trans_reg; pfam01037
591020003025	DNA translocase FtsK; Provisional; Region: PRK10263
591020003026	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
591020003027	DNA translocase FtsK; Provisional; Region: PRK10263
591020003028	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
591020003029	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
591020003030	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
591020003031	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
591020003032	recombination factor protein RarA; Reviewed; Region: PRK13342
591020003033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020003034	Walker A motif; other site
591020003035	ATP binding site [chemical binding]; other site
591020003036	Walker B motif; other site
591020003037	arginine finger; other site
591020003038	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
591020003039	seryl-tRNA synthetase; Provisional; Region: PRK05431
591020003040	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
591020003041	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
591020003042	dimer interface [polypeptide binding]; other site
591020003043	active site
591020003044	motif 1; other site
591020003045	motif 2; other site
591020003046	motif 3; other site
591020003047	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
591020003048	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
591020003049	putative molybdopterin cofactor binding site [chemical binding]; other site
591020003050	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
591020003051	putative molybdopterin cofactor binding site; other site
591020003052	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
591020003053	4Fe-4S binding domain; Region: Fer4; pfam00037
591020003054	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
591020003055	Isochorismatase family; Region: Isochorismatase; pfam00857
591020003056	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
591020003057	catalytic triad [active]
591020003058	dimer interface [polypeptide binding]; other site
591020003059	conserved cis-peptide bond; other site
591020003060	putative MFS family transporter protein; Provisional; Region: PRK03633
591020003061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020003062	putative substrate translocation pore; other site
591020003063	Homeodomain-like domain; Region: HTH_23; pfam13384
591020003064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003065	Transposase; Region: HTH_Tnp_1; pfam01527
591020003066	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020003067	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020003068	Integrase core domain; Region: rve_3; pfam13683
591020003069	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
591020003070	putative transposase OrfB; Reviewed; Region: PHA02517
591020003071	HTH-like domain; Region: HTH_21; pfam13276
591020003072	Integrase core domain; Region: rve; pfam00665
591020003073	Integrase core domain; Region: rve_3; pfam13683
591020003074	Hok/gef family; Region: HOK_GEF; pfam01848
591020003075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
591020003076	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
591020003077	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
591020003078	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
591020003079	transcriptional repressor DicA; Reviewed; Region: PRK09706
591020003080	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020003081	sequence-specific DNA binding site [nucleotide binding]; other site
591020003082	salt bridge; other site
591020003083	Protein of unknown function (DUF1391); Region: DUF1391; pfam07151
591020003084	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020003085	HTH-like domain; Region: HTH_21; pfam13276
591020003086	Integrase core domain; Region: rve; pfam00665
591020003087	Integrase core domain; Region: rve_3; pfam13683
591020003088	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020003089	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003090	Ash protein family; Region: Phage_ASH; pfam10554
591020003091	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
591020003092	hypothetical protein; Reviewed; Region: PRK09790
591020003093	putative transposase OrfB; Reviewed; Region: PHA02517
591020003094	Integrase core domain; Region: rve; pfam00665
591020003095	Integrase core domain; Region: rve_3; pfam13683
591020003096	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
591020003097	hypothetical protein; Reviewed; Region: PRK09790
591020003098	Integrase core domain; Region: rve; pfam00665
591020003099	Integrase core domain; Region: rve_3; pfam13683
591020003100	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003101	Transposase; Region: HTH_Tnp_1; pfam01527
591020003102	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
591020003103	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020003104	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
591020003105	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
591020003106	catalytic nucleophile [active]
591020003107	6-phosphogluconolactonase; Provisional; Region: PRK11028
591020003108	PrpF protein; Region: PrpF; pfam04303
591020003109	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591020003110	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
591020003111	transmembrane helices; other site
591020003112	putative hydratase; Provisional; Region: PRK11413
591020003113	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
591020003114	substrate binding site [chemical binding]; other site
591020003115	ligand binding site [chemical binding]; other site
591020003116	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
591020003117	substrate binding site [chemical binding]; other site
591020003118	acyl-CoA thioesterase; Provisional; Region: PRK10531
591020003119	putative pectinesterase; Region: PLN02432; cl01911
591020003120	putative transposase OrfB; Reviewed; Region: PHA02517
591020003121	Integrase core domain; Region: rve; pfam00665
591020003122	Integrase core domain; Region: rve_3; pfam13683
591020003123	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
591020003124	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020003125	FeS/SAM binding site; other site
591020003126	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
591020003127	formate transporter; Provisional; Region: PRK10805
591020003128	uncharacterized domain; Region: TIGR00702
591020003129	YcaO-like family; Region: YcaO; pfam02624
591020003130	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
591020003131	homodimer interface [polypeptide binding]; other site
591020003132	substrate-cofactor binding pocket; other site
591020003133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020003134	catalytic residue [active]
591020003135	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
591020003136	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
591020003137	hinge; other site
591020003138	active site
591020003139	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020003140	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020003141	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020003142	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
591020003143	cytidylate kinase; Provisional; Region: cmk; PRK00023
591020003144	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
591020003145	CMP-binding site; other site
591020003146	The sites determining sugar specificity; other site
591020003147	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
591020003148	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
591020003149	RNA binding site [nucleotide binding]; other site
591020003150	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
591020003151	RNA binding site [nucleotide binding]; other site
591020003152	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
591020003153	RNA binding site [nucleotide binding]; other site
591020003154	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
591020003155	RNA binding site [nucleotide binding]; other site
591020003156	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
591020003157	RNA binding site [nucleotide binding]; other site
591020003158	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591020003159	IHF dimer interface [polypeptide binding]; other site
591020003160	IHF - DNA interface [nucleotide binding]; other site
591020003161	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
591020003162	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
591020003163	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
591020003164	Walker A/P-loop; other site
591020003165	ATP binding site [chemical binding]; other site
591020003166	Q-loop/lid; other site
591020003167	ABC transporter signature motif; other site
591020003168	Walker B; other site
591020003169	D-loop; other site
591020003170	H-loop/switch region; other site
591020003171	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
591020003172	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
591020003173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
591020003174	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
591020003175	hypothetical protein; Provisional; Region: PRK11827
591020003176	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
591020003177	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
591020003178	Ligand binding site; other site
591020003179	oligomer interface; other site
591020003180	hypothetical protein; Provisional; Region: PRK10593
591020003181	Uncharacterized conserved protein [Function unknown]; Region: COG1434
591020003182	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591020003183	putative active site [active]
591020003184	Methyltransferase domain; Region: Methyltransf_31; pfam13847
591020003185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020003186	S-adenosylmethionine binding site [chemical binding]; other site
591020003187	condesin subunit F; Provisional; Region: PRK05260
591020003188	condesin subunit E; Provisional; Region: PRK05256
591020003189	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
591020003190	MukB N-terminal; Region: MukB; pfam04310
591020003191	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
591020003192	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020003193	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020003194	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020003195	murein L,D-transpeptidase; Provisional; Region: PRK10594
591020003196	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
591020003197	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591020003198	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591020003199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
591020003200	Peptidase M15; Region: Peptidase_M15_3; cl01194
591020003201	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
591020003202	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
591020003203	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591020003204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020003205	homodimer interface [polypeptide binding]; other site
591020003206	catalytic residue [active]
591020003207	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591020003208	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591020003209	trimer interface [polypeptide binding]; other site
591020003210	eyelet of channel; other site
591020003211	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
591020003212	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
591020003213	putative dimer interface [polypeptide binding]; other site
591020003214	putative anticodon binding site; other site
591020003215	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
591020003216	homodimer interface [polypeptide binding]; other site
591020003217	motif 1; other site
591020003218	motif 2; other site
591020003219	active site
591020003220	motif 3; other site
591020003221	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
591020003222	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
591020003223	active site
591020003224	aminopeptidase N; Provisional; Region: pepN; PRK14015
591020003225	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
591020003226	active site
591020003227	Zn binding site [ion binding]; other site
591020003228	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
591020003229	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020003230	Walker A/P-loop; other site
591020003231	ATP binding site [chemical binding]; other site
591020003232	Q-loop/lid; other site
591020003233	ABC transporter signature motif; other site
591020003234	Walker B; other site
591020003235	D-loop; other site
591020003236	H-loop/switch region; other site
591020003237	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020003238	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003239	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
591020003240	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
591020003241	active site
591020003242	dimer interface [polypeptide binding]; other site
591020003243	non-prolyl cis peptide bond; other site
591020003244	insertion regions; other site
591020003245	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020003246	substrate binding pocket [chemical binding]; other site
591020003247	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
591020003248	membrane-bound complex binding site; other site
591020003249	hinge residues; other site
591020003250	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
591020003251	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591020003252	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020003253	Fimbrial protein; Region: Fimbrial; cl01416
591020003254	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020003255	outer membrane usher protein; Provisional; Region: PRK15193
591020003256	PapC N-terminal domain; Region: PapC_N; pfam13954
591020003257	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020003258	PapC C-terminal domain; Region: PapC_C; pfam13953
591020003259	Fimbrial protein; Region: Fimbrial; cl01416
591020003260	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591020003261	putativi pili assembly chaperone; Provisional; Region: PRK11385
591020003262	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591020003263	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591020003264	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
591020003265	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
591020003266	quinone interaction residues [chemical binding]; other site
591020003267	active site
591020003268	catalytic residues [active]
591020003269	FMN binding site [chemical binding]; other site
591020003270	substrate binding site [chemical binding]; other site
591020003271	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
591020003272	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
591020003273	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
591020003274	MOSC domain; Region: MOSC; pfam03473
591020003275	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591020003276	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
591020003277	catalytic loop [active]
591020003278	iron binding site [ion binding]; other site
591020003279	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
591020003280	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
591020003281	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
591020003282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020003283	S-adenosylmethionine binding site [chemical binding]; other site
591020003284	ABC transporter ATPase component; Reviewed; Region: PRK11147
591020003285	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020003286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020003287	Walker A/P-loop; other site
591020003288	Walker A/P-loop; other site
591020003289	ATP binding site [chemical binding]; other site
591020003290	ATP binding site [chemical binding]; other site
591020003291	Q-loop/lid; other site
591020003292	Q-loop/lid; other site
591020003293	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591020003294	ABC transporter signature motif; other site
591020003295	Walker B; other site
591020003296	D-loop; other site
591020003297	ABC transporter; Region: ABC_tran_2; pfam12848
591020003298	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591020003299	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
591020003300	Paraquat-inducible protein A; Region: PqiA; pfam04403
591020003301	Paraquat-inducible protein A; Region: PqiA; pfam04403
591020003302	paraquat-inducible protein B; Provisional; Region: PRK10807
591020003303	mce related protein; Region: MCE; pfam02470
591020003304	mce related protein; Region: MCE; pfam02470
591020003305	mce related protein; Region: MCE; pfam02470
591020003306	DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651
591020003307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
591020003308	Protein of unknown function (DUF330); Region: DUF330; pfam03886
591020003309	Ribosome modulation factor; Region: RMF; pfam04957
591020003310	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
591020003311	active site 1 [active]
591020003312	dimer interface [polypeptide binding]; other site
591020003313	active site 2 [active]
591020003314	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
591020003315	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
591020003316	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
591020003317	outer membrane protein A; Reviewed; Region: PRK10808
591020003318	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
591020003319	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591020003320	ligand binding site [chemical binding]; other site
591020003321	cell division inhibitor SulA; Region: sula; TIGR00623
591020003322	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
591020003323	TfoX C-terminal domain; Region: TfoX_C; pfam04994
591020003324	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020003325	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003326	HTH-like domain; Region: HTH_21; pfam13276
591020003327	Integrase core domain; Region: rve; pfam00665
591020003328	TIGR01666 family membrane protein; Region: YCCS
591020003329	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
591020003330	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591020003331	Predicted membrane protein [Function unknown]; Region: COG3304
591020003332	Domain of unknown function (DUF307); Region: DUF307; pfam03733
591020003333	Domain of unknown function (DUF307); Region: DUF307; pfam03733
591020003334	DNA helicase IV; Provisional; Region: helD; PRK11054
591020003335	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
591020003336	Part of AAA domain; Region: AAA_19; pfam13245
591020003337	Family description; Region: UvrD_C_2; pfam13538
591020003338	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
591020003339	active site
591020003340	dimer interfaces [polypeptide binding]; other site
591020003341	catalytic residues [active]
591020003342	hypothetical protein; Provisional; Region: PRK03641
591020003343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
591020003344	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
591020003345	heat shock protein HspQ; Provisional; Region: PRK14129
591020003346	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
591020003347	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
591020003348	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
591020003349	putative RNA binding site [nucleotide binding]; other site
591020003350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020003351	S-adenosylmethionine binding site [chemical binding]; other site
591020003352	Acylphosphatase; Region: Acylphosphatase; cl00551
591020003353	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
591020003354	sulfur transfer protein TusE; Provisional; Region: PRK11508
591020003355	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
591020003356	YccA-like proteins; Region: YccA_like; cd10433
591020003357	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
591020003358	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
591020003359	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
591020003360	hydrogenase 1 large subunit; Provisional; Region: PRK10170
591020003361	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
591020003362	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
591020003363	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
591020003364	putative substrate-binding site; other site
591020003365	nickel binding site [ion binding]; other site
591020003366	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
591020003367	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
591020003368	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
591020003369	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
591020003370	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
591020003371	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
591020003372	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
591020003373	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591020003374	catalytic core [active]
591020003375	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591020003376	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
591020003377	Chain length determinant protein; Region: Wzz; cl15801
591020003378	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
591020003379	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
591020003380	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
591020003381	Nucleotide binding site [chemical binding]; other site
591020003382	Low molecular weight phosphatase family; Region: LMWPc; cd00115
591020003383	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
591020003384	active site
591020003385	polysaccharide export protein Wza; Provisional; Region: PRK15078
591020003386	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
591020003387	SLBB domain; Region: SLBB; pfam10531
591020003388	SLBB domain; Region: SLBB; pfam10531
591020003389	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
591020003390	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
591020003391	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
591020003392	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591020003393	DNA-binding site [nucleotide binding]; DNA binding site
591020003394	RNA-binding motif; other site
591020003395	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020003396	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591020003397	DNA-binding site [nucleotide binding]; DNA binding site
591020003398	RNA-binding motif; other site
591020003399	cold shock gene; Provisional; Region: PRK09891
591020003400	GnsA/GnsB family; Region: GnsAB; pfam08178
591020003401	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
591020003402	4Fe-4S binding domain; Region: Fer4_5; pfam12801
591020003403	4Fe-4S binding domain; Region: Fer4_5; pfam12801
591020003404	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591020003405	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
591020003406	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
591020003407	putative ligand binding site [chemical binding]; other site
591020003408	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
591020003409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020003410	active site
591020003411	phosphorylation site [posttranslational modification]
591020003412	intermolecular recognition site; other site
591020003413	dimerization interface [polypeptide binding]; other site
591020003414	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020003415	DNA binding site [nucleotide binding]
591020003416	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
591020003417	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
591020003418	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020003419	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
591020003420	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
591020003421	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
591020003422	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591020003423	HSP70 interaction site [polypeptide binding]; other site
591020003424	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
591020003425	substrate binding site [polypeptide binding]; other site
591020003426	dimer interface [polypeptide binding]; other site
591020003427	hypothetical protein; Provisional; Region: PRK09784
591020003428	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
591020003429	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591020003430	catalytic core [active]
591020003431	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
591020003432	hypothetical protein; Provisional; Region: PRK10174
591020003433	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
591020003434	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591020003435	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
591020003436	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
591020003437	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
591020003438	putative FMN binding site [chemical binding]; other site
591020003439	pyrimidine utilization protein D; Region: RutD; TIGR03611
591020003440	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
591020003441	homotrimer interaction site [polypeptide binding]; other site
591020003442	putative active site [active]
591020003443	Isochorismatase family; Region: Isochorismatase; pfam00857
591020003444	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
591020003445	catalytic triad [active]
591020003446	conserved cis-peptide bond; other site
591020003447	pyrimidine utilization protein A; Region: RutA; TIGR03612
591020003448	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
591020003449	active site
591020003450	dimer interface [polypeptide binding]; other site
591020003451	non-prolyl cis peptide bond; other site
591020003452	insertion regions; other site
591020003453	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
591020003454	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
591020003455	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020003456	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
591020003457	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020003458	Putative transposase; Region: Y2_Tnp; pfam04986
591020003459	Iron permease FTR1 family; Region: FTR1; cl00475
591020003460	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
591020003461	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
591020003462	Imelysin; Region: Peptidase_M75; pfam09375
591020003463	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
591020003464	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
591020003465	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
591020003466	hypothetical protein; Provisional; Region: PRK10536
591020003467	Transposase; Region: HTH_Tnp_1; cl17663
591020003468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003469	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
591020003470	SRL-like pathogenicity island
591020003471	integrase; Provisional; Region: PRK09692
591020003472	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591020003473	active site
591020003474	Int/Topo IB signature motif; other site
591020003475	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
591020003476	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
591020003477	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
591020003478	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
591020003479	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
591020003480	Integrase core domain; Region: rve; pfam00665
591020003481	Integrase core domain; Region: rve_3; pfam13683
591020003482	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
591020003483	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
591020003484	putative active site [active]
591020003485	putative NTP binding site [chemical binding]; other site
591020003486	putative nucleic acid binding site [nucleotide binding]; other site
591020003487	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
591020003488	HTH-like domain; Region: HTH_21; pfam13276
591020003489	Transposase; Region: HTH_Tnp_1; cl17663
591020003490	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003491	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591020003492	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591020003493	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020003494	Transposase; Region: HTH_Tnp_1; cl17663
591020003495	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003496	putative transposase OrfB; Reviewed; Region: PHA02517
591020003497	HTH-like domain; Region: HTH_21; pfam13276
591020003498	Integrase core domain; Region: rve; pfam00665
591020003499	Integrase core domain; Region: rve_2; pfam13333
591020003500	Predicted membrane protein [Function unknown]; Region: COG4325
591020003501	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
591020003502	BCCT family transporter; Region: BCCT; cl00569
591020003503	putative transposase OrfB; Reviewed; Region: PHA02517
591020003504	Integrase core domain; Region: rve; pfam00665
591020003505	Integrase core domain; Region: rve_3; pfam13683
591020003506	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591020003507	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591020003508	putative acyl-acceptor binding pocket; other site
591020003509	Protein of unknown function (DUF535); Region: DUF535; pfam04393
591020003510	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
591020003511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591020003512	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
591020003513	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
591020003514	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020003515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020003516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591020003517	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020003518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020003519	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020003520	putative substrate translocation pore; other site
591020003521	tetracycline repressor protein TetR; Provisional; Region: PRK13756
591020003522	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020003523	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
591020003524	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
591020003525	aminoglycoside resistance protein; Provisional; Region: PRK13746
591020003526	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
591020003527	active site
591020003528	NTP binding site [chemical binding]; other site
591020003529	metal binding triad [ion binding]; metal-binding site
591020003530	antibiotic binding site [chemical binding]; other site
591020003531	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
591020003532	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
591020003533	integrase/recombinase; Provisional; Region: PRK15417
591020003534	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
591020003535	Int/Topo IB signature motif; other site
591020003536	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020003537	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
591020003538	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
591020003539	multiple promoter invertase; Provisional; Region: mpi; PRK13413
591020003540	catalytic residues [active]
591020003541	catalytic nucleophile [active]
591020003542	Presynaptic Site I dimer interface [polypeptide binding]; other site
591020003543	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
591020003544	Synaptic Flat tetramer interface [polypeptide binding]; other site
591020003545	Synaptic Site I dimer interface [polypeptide binding]; other site
591020003546	DNA binding site [nucleotide binding]
591020003547	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
591020003548	DNA-binding interface [nucleotide binding]; DNA binding site
591020003549	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
591020003550	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
591020003551	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591020003552	chloramphenicol acetyltransferase; Provisional; Region: PRK13757
591020003553	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
591020003554	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020003555	tetracycline repressor protein TetR; Provisional; Region: PRK13756
591020003556	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020003557	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
591020003558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020003559	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020003560	putative substrate translocation pore; other site
591020003561	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
591020003562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020003563	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020003564	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
591020003565	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428
591020003566	Domain of unknown function (DUF932); Region: DUF932; pfam06067
591020003567	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
591020003568	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
591020003569	MPN+ (JAMM) motif; other site
591020003570	Zinc-binding site [ion binding]; other site
591020003571	Protein of unknown function (DUF987); Region: DUF987; pfam06174
591020003572	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
591020003573	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
591020003574	Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117
591020003575	Methyltransferase domain; Region: Methyltransf_27; pfam13708
591020003576	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
591020003577	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020003578	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020003579	Methyltransferase domain; Region: Methyltransf_27; pfam13708
591020003580	putative hydrolase; Validated; Region: PRK09248
591020003581	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
591020003582	active site
591020003583	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
591020003584	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
591020003585	curli assembly protein CsgF; Provisional; Region: PRK10050
591020003586	curli assembly protein CsgE; Provisional; Region: PRK10386
591020003587	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
591020003588	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020003589	DNA binding residues [nucleotide binding]
591020003590	dimerization interface [polypeptide binding]; other site
591020003591	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
591020003592	Curlin associated repeat; Region: Curlin_rpt; pfam07012
591020003593	Curlin associated repeat; Region: Curlin_rpt; pfam07012
591020003594	Integrase core domain; Region: rve; pfam00665
591020003595	Integrase core domain; Region: rve_3; pfam13683
591020003596	Fimbrial protein; Region: Fimbrial; cl01416
591020003597	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
591020003598	putative ADP-ribose binding site [chemical binding]; other site
591020003599	putative active site [active]
591020003600	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
591020003601	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
591020003602	putative active site [active]
591020003603	catalytic site [active]
591020003604	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
591020003605	putative active site [active]
591020003606	catalytic site [active]
591020003607	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
591020003608	Acyltransferase family; Region: Acyl_transf_3; pfam01757
591020003609	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
591020003610	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
591020003611	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
591020003612	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
591020003613	Ligand binding site; other site
591020003614	DXD motif; other site
591020003615	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020003616	Putative transposase; Region: Y2_Tnp; pfam04986
591020003617	tape measure domain; Region: tape_meas_nterm; TIGR02675
591020003618	HTH-like domain; Region: HTH_21; pfam13276
591020003619	Integrase core domain; Region: rve; pfam00665
591020003620	Integrase core domain; Region: rve_3; pfam13683
591020003621	Transposase; Region: HTH_Tnp_1; cl17663
591020003622	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003623	Integrase core domain; Region: rve; pfam00665
591020003624	Integrase core domain; Region: rve_3; pfam13683
591020003625	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020003626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003627	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020003628	HTH-like domain; Region: HTH_21; pfam13276
591020003629	Integrase core domain; Region: rve; pfam00665
591020003630	Integrase core domain; Region: rve_3; pfam13683
591020003631	Transposase; Region: HTH_Tnp_1; cl17663
591020003632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003633	HTH-like domain; Region: HTH_21; pfam13276
591020003634	Integrase core domain; Region: rve; pfam00665
591020003635	Integrase core domain; Region: rve_3; pfam13683
591020003636	putative transposase OrfB; Reviewed; Region: PHA02517
591020003637	Integrase core domain; Region: rve; pfam00665
591020003638	Integrase core domain; Region: rve_3; pfam13683
591020003639	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
591020003640	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
591020003641	catalytic residues [active]
591020003642	catalytic nucleophile [active]
591020003643	Recombinase; Region: Recombinase; pfam07508
591020003644	drug efflux system protein MdtG; Provisional; Region: PRK09874
591020003645	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591020003646	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591020003647	putative acyl-acceptor binding pocket; other site
591020003648	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
591020003649	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
591020003650	active site residue [active]
591020003651	hypothetical protein; Provisional; Region: PRK03757
591020003652	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
591020003653	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
591020003654	hydroxyglutarate oxidase; Provisional; Region: PRK11728
591020003655	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
591020003656	DNA damage-inducible protein I; Provisional; Region: PRK10597
591020003657	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
591020003658	active site
591020003659	substrate binding pocket [chemical binding]; other site
591020003660	dimer interface [polypeptide binding]; other site
591020003661	lipoprotein; Provisional; Region: PRK10598
591020003662	glutaredoxin 2; Provisional; Region: PRK10387
591020003663	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
591020003664	C-terminal domain interface [polypeptide binding]; other site
591020003665	GSH binding site (G-site) [chemical binding]; other site
591020003666	catalytic residues [active]
591020003667	putative dimer interface [polypeptide binding]; other site
591020003668	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
591020003669	N-terminal domain interface [polypeptide binding]; other site
591020003670	multidrug resistance protein MdtH; Provisional; Region: PRK11646
591020003671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020003672	putative substrate translocation pore; other site
591020003673	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
591020003674	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
591020003675	hypothetical protein; Provisional; Region: PRK11239
591020003676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
591020003677	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
591020003678	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591020003679	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591020003680	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
591020003681	MviN-like protein; Region: MVIN; pfam03023
591020003682	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
591020003683	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
591020003684	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
591020003685	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
591020003686	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
591020003687	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
591020003688	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
591020003689	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
591020003690	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
591020003691	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
591020003692	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
591020003693	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
591020003694	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
591020003695	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
591020003696	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
591020003697	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
591020003698	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
591020003699	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
591020003700	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
591020003701	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
591020003702	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
591020003703	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
591020003704	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
591020003705	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
591020003706	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
591020003707	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
591020003708	homodimer interface [polypeptide binding]; other site
591020003709	oligonucleotide binding site [chemical binding]; other site
591020003710	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
591020003711	Protein of unknown function (DUF2655); Region: DUF2655; pfam10848
591020003712	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
591020003713	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020003714	RNA binding surface [nucleotide binding]; other site
591020003715	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591020003716	active site
591020003717	Maf-like protein; Region: Maf; pfam02545
591020003718	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
591020003719	active site
591020003720	dimer interface [polypeptide binding]; other site
591020003721	hypothetical protein; Provisional; Region: PRK11193
591020003722	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
591020003723	putative phosphate acyltransferase; Provisional; Region: PRK05331
591020003724	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
591020003725	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
591020003726	dimer interface [polypeptide binding]; other site
591020003727	active site
591020003728	CoA binding pocket [chemical binding]; other site
591020003729	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
591020003730	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
591020003731	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
591020003732	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
591020003733	NAD(P) binding site [chemical binding]; other site
591020003734	homotetramer interface [polypeptide binding]; other site
591020003735	homodimer interface [polypeptide binding]; other site
591020003736	active site
591020003737	acyl carrier protein; Provisional; Region: acpP; PRK00982
591020003738	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
591020003739	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
591020003740	dimer interface [polypeptide binding]; other site
591020003741	active site
591020003742	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
591020003743	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
591020003744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020003745	catalytic residue [active]
591020003746	conserved hypothetical protein, YceG family; Region: TIGR00247
591020003747	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
591020003748	dimerization interface [polypeptide binding]; other site
591020003749	thymidylate kinase; Validated; Region: tmk; PRK00698
591020003750	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
591020003751	TMP-binding site; other site
591020003752	ATP-binding site [chemical binding]; other site
591020003753	DNA polymerase III subunit delta'; Validated; Region: PRK07993
591020003754	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
591020003755	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
591020003756	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
591020003757	active site
591020003758	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
591020003759	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591020003760	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591020003761	active site turn [active]
591020003762	phosphorylation site [posttranslational modification]
591020003763	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
591020003764	nucleotide binding site/active site [active]
591020003765	HIT family signature motif; other site
591020003766	catalytic residue [active]
591020003767	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
591020003768	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
591020003769	putative dimer interface [polypeptide binding]; other site
591020003770	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
591020003771	thiamine kinase; Region: ycfN_thiK; TIGR02721
591020003772	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
591020003773	active site
591020003774	substrate binding site [chemical binding]; other site
591020003775	ATP binding site [chemical binding]; other site
591020003776	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
591020003777	beta-hexosaminidase; Provisional; Region: PRK05337
591020003778	hypothetical protein; Provisional; Region: PRK04940
591020003779	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
591020003780	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020003781	hypothetical protein; Provisional; Region: PRK11280
591020003782	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591020003783	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020003784	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591020003785	L,D-transpeptidase; Provisional; Region: PRK10260
591020003786	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020003787	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591020003788	transcription-repair coupling factor; Provisional; Region: PRK10689
591020003789	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
591020003790	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020003791	ATP binding site [chemical binding]; other site
591020003792	putative Mg++ binding site [ion binding]; other site
591020003793	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020003794	nucleotide binding region [chemical binding]; other site
591020003795	ATP-binding site [chemical binding]; other site
591020003796	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
591020003797	Predicted membrane protein [Function unknown]; Region: COG4763
591020003798	Acyltransferase family; Region: Acyl_transf_3; pfam01757
591020003799	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
591020003800	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
591020003801	FtsX-like permease family; Region: FtsX; pfam02687
591020003802	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
591020003803	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
591020003804	Walker A/P-loop; other site
591020003805	ATP binding site [chemical binding]; other site
591020003806	Q-loop/lid; other site
591020003807	ABC transporter signature motif; other site
591020003808	Walker B; other site
591020003809	D-loop; other site
591020003810	H-loop/switch region; other site
591020003811	fructokinase; Reviewed; Region: PRK09557
591020003812	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591020003813	nucleotide binding site [chemical binding]; other site
591020003814	NAD-dependent deacetylase; Provisional; Region: PRK00481
591020003815	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
591020003816	NAD+ binding site [chemical binding]; other site
591020003817	substrate binding site [chemical binding]; other site
591020003818	Zn binding site [ion binding]; other site
591020003819	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
591020003820	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
591020003821	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591020003822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020003823	dimer interface [polypeptide binding]; other site
591020003824	conserved gate region; other site
591020003825	putative PBP binding loops; other site
591020003826	ABC-ATPase subunit interface; other site
591020003827	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591020003828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020003829	dimer interface [polypeptide binding]; other site
591020003830	conserved gate region; other site
591020003831	putative PBP binding loops; other site
591020003832	ABC-ATPase subunit interface; other site
591020003833	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
591020003834	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020003835	Walker A/P-loop; other site
591020003836	ATP binding site [chemical binding]; other site
591020003837	Q-loop/lid; other site
591020003838	ABC transporter signature motif; other site
591020003839	Walker B; other site
591020003840	D-loop; other site
591020003841	H-loop/switch region; other site
591020003842	TOBE domain; Region: TOBE_2; pfam08402
591020003843	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
591020003844	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
591020003845	metal binding site [ion binding]; metal-binding site
591020003846	dimer interface [polypeptide binding]; other site
591020003847	Uncharacterized conserved protein [Function unknown]; Region: COG2850
591020003848	Cupin-like domain; Region: Cupin_8; pfam13621
591020003849	integrase; Provisional; Region: PRK09692
591020003850	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591020003851	active site
591020003852	Int/Topo IB signature motif; other site
591020003853	Domain of unknown function (DUF4222); Region: DUF4222; pfam13973
591020003854	D5 N terminal like; Region: D5_N; smart00885
591020003855	Phage associated DNA primase [General function prediction only]; Region: COG3378
591020003856	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
591020003857	PerC transcriptional activator; Region: PerC; pfam06069
591020003858	Phage head maturation protease [General function prediction only]; Region: COG3740
591020003859	Phage-related protein [Function unknown]; Region: COG4695
591020003860	Phage portal protein; Region: Phage_portal; pfam04860
591020003861	Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614
591020003862	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
591020003863	oligomerization interface [polypeptide binding]; other site
591020003864	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
591020003865	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
591020003866	active site
591020003867	Phage terminase, small subunit; Region: Terminase_4; cl01525
591020003868	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
591020003869	sensor protein PhoQ; Provisional; Region: PRK10815
591020003870	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
591020003871	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
591020003872	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
591020003873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020003874	ATP binding site [chemical binding]; other site
591020003875	Mg2+ binding site [ion binding]; other site
591020003876	G-X-G motif; other site
591020003877	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
591020003878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020003879	active site
591020003880	phosphorylation site [posttranslational modification]
591020003881	intermolecular recognition site; other site
591020003882	dimerization interface [polypeptide binding]; other site
591020003883	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020003884	DNA binding site [nucleotide binding]
591020003885	adenylosuccinate lyase; Provisional; Region: PRK09285
591020003886	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
591020003887	tetramer interface [polypeptide binding]; other site
591020003888	active site
591020003889	putative lysogenization regulator; Reviewed; Region: PRK00218
591020003890	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
591020003891	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
591020003892	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
591020003893	nudix motif; other site
591020003894	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
591020003895	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
591020003896	probable active site [active]
591020003897	isocitrate dehydrogenase; Validated; Region: PRK07362
591020003898	isocitrate dehydrogenase; Reviewed; Region: PRK07006
591020003899	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020003900	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591020003901	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020003902	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
591020003903	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
591020003904	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020003905	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591020003906	Autotransporter beta-domain; Region: Autotransporter; smart00869
591020003907	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
591020003908	cell division inhibitor MinD; Provisional; Region: PRK10818
591020003909	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
591020003910	Switch I; other site
591020003911	Switch II; other site
591020003912	septum formation inhibitor; Reviewed; Region: minC; PRK03511
591020003913	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
591020003914	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
591020003915	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
591020003916	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020003917	HTH-like domain; Region: HTH_21; pfam13276
591020003918	Integrase core domain; Region: rve; pfam00665
591020003919	Integrase core domain; Region: rve_3; pfam13683
591020003920	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020003921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003922	Transposase; Region: HTH_Tnp_1; cl17663
591020003923	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020003924	putative transposase OrfB; Reviewed; Region: PHA02517
591020003925	HTH-like domain; Region: HTH_21; pfam13276
591020003926	Integrase core domain; Region: rve; pfam00665
591020003927	Integrase core domain; Region: rve_2; pfam13333
591020003928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
591020003929	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
591020003930	hypothetical protein; Provisional; Region: PRK10691
591020003931	hypothetical protein; Provisional; Region: PRK05170
591020003932	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
591020003933	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591020003934	Catalytic site [active]
591020003935	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
591020003936	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
591020003937	active site
591020003938	DNA binding site [nucleotide binding]
591020003939	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
591020003940	disulfide bond formation protein B; Provisional; Region: PRK01749
591020003941	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
591020003942	transmembrane helices; other site
591020003943	fatty acid metabolism regulator; Provisional; Region: PRK04984
591020003944	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020003945	DNA-binding site [nucleotide binding]; DNA binding site
591020003946	FadR C-terminal domain; Region: FadR_C; pfam07840
591020003947	SpoVR family protein; Provisional; Region: PRK11767
591020003948	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
591020003949	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
591020003950	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020003951	alanine racemase; Reviewed; Region: dadX; PRK03646
591020003952	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
591020003953	active site
591020003954	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591020003955	substrate binding site [chemical binding]; other site
591020003956	catalytic residues [active]
591020003957	dimer interface [polypeptide binding]; other site
591020003958	Leucine rich repeat; Region: LRR_8; pfam13855
591020003959	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
591020003960	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
591020003961	TrkA-C domain; Region: TrkA_C; pfam02080
591020003962	Transporter associated domain; Region: CorC_HlyC; smart01091
591020003963	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
591020003964	dimer interface [polypeptide binding]; other site
591020003965	catalytic triad [active]
591020003966	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
591020003967	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020003968	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020003969	catalytic residue [active]
591020003970	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
591020003971	Flagellar regulator YcgR; Region: YcgR; pfam07317
591020003972	PilZ domain; Region: PilZ; pfam07238
591020003973	hypothetical protein; Provisional; Region: PRK10457
591020003974	molybdenum transport protein ModD; Provisional; Region: PRK06096
591020003975	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
591020003976	dimerization interface [polypeptide binding]; other site
591020003977	active site
591020003978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020003979	S-adenosylmethionine binding site [chemical binding]; other site
591020003980	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
591020003981	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591020003982	Walker A/P-loop; other site
591020003983	ATP binding site [chemical binding]; other site
591020003984	Q-loop/lid; other site
591020003985	ABC transporter signature motif; other site
591020003986	Walker B; other site
591020003987	D-loop; other site
591020003988	H-loop/switch region; other site
591020003989	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591020003990	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020003991	ABC-ATPase subunit  interface; other site
591020003992	dimer interface [polypeptide binding]; other site
591020003993	putative PBP binding regions; other site
591020003994	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
591020003995	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
591020003996	putative metal binding site [ion binding]; other site
591020003997	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020003998	trehalase; Provisional; Region: treA; PRK13271
591020003999	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
591020004000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412
591020004001	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
591020004002	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591020004003	dimerization domain swap beta strand [polypeptide binding]; other site
591020004004	regulatory protein interface [polypeptide binding]; other site
591020004005	active site
591020004006	regulatory phosphorylation site [posttranslational modification]; other site
591020004007	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591020004008	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591020004009	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
591020004010	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
591020004011	Dak1 domain; Region: Dak1; pfam02733
591020004012	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
591020004013	PAS domain; Region: PAS; smart00091
591020004014	putative active site [active]
591020004015	heme pocket [chemical binding]; other site
591020004016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020004017	Walker A motif; other site
591020004018	ATP binding site [chemical binding]; other site
591020004019	Walker B motif; other site
591020004020	arginine finger; other site
591020004021	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591020004022	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
591020004023	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020004024	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591020004025	GTP-binding protein YchF; Reviewed; Region: PRK09601
591020004026	YchF GTPase; Region: YchF; cd01900
591020004027	G1 box; other site
591020004028	GTP/Mg2+ binding site [chemical binding]; other site
591020004029	Switch I region; other site
591020004030	G2 box; other site
591020004031	Switch II region; other site
591020004032	G3 box; other site
591020004033	G4 box; other site
591020004034	G5 box; other site
591020004035	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
591020004036	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
591020004037	putative active site [active]
591020004038	catalytic residue [active]
591020004039	hypothetical protein; Provisional; Region: PRK10692
591020004040	putative transporter; Provisional; Region: PRK11660
591020004041	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
591020004042	Sulfate transporter family; Region: Sulfate_transp; pfam00916
591020004043	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
591020004044	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
591020004045	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
591020004046	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020004047	active site
591020004048	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
591020004049	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
591020004050	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
591020004051	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
591020004052	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
591020004053	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
591020004054	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
591020004055	tRNA; other site
591020004056	putative tRNA binding site [nucleotide binding]; other site
591020004057	putative NADP binding site [chemical binding]; other site
591020004058	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
591020004059	peptide chain release factor 1; Validated; Region: prfA; PRK00591
591020004060	This domain is found in peptide chain release factors; Region: PCRF; smart00937
591020004061	RF-1 domain; Region: RF-1; pfam00472
591020004062	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
591020004063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020004064	hypothetical protein; Provisional; Region: PRK10278
591020004065	hypothetical protein; Provisional; Region: PRK10941
591020004066	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
591020004067	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
591020004068	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591020004069	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
591020004070	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
591020004071	cation transport regulator; Reviewed; Region: chaB; PRK09582
591020004072	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
591020004073	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
591020004074	putative active site pocket [active]
591020004075	dimerization interface [polypeptide binding]; other site
591020004076	putative catalytic residue [active]
591020004077	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
591020004078	putative invasin; Provisional; Region: PRK10177
591020004079	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
591020004080	transcriptional regulator NarL; Provisional; Region: PRK10651
591020004081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020004082	active site
591020004083	phosphorylation site [posttranslational modification]
591020004084	intermolecular recognition site; other site
591020004085	dimerization interface [polypeptide binding]; other site
591020004086	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020004087	DNA binding residues [nucleotide binding]
591020004088	dimerization interface [polypeptide binding]; other site
591020004089	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
591020004090	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
591020004091	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020004092	dimerization interface [polypeptide binding]; other site
591020004093	Histidine kinase; Region: HisKA_3; pfam07730
591020004094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020004095	ATP binding site [chemical binding]; other site
591020004096	Mg2+ binding site [ion binding]; other site
591020004097	G-X-G motif; other site
591020004098	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
591020004099	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
591020004100	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
591020004101	[4Fe-4S] binding site [ion binding]; other site
591020004102	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591020004103	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591020004104	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591020004105	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
591020004106	molybdopterin cofactor binding site; other site
591020004107	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
591020004108	4Fe-4S binding domain; Region: Fer4; cl02805
591020004109	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
591020004110	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
591020004111	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
591020004112	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
591020004113	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
591020004114	putative active site [active]
591020004115	putative substrate binding site [chemical binding]; other site
591020004116	putative cosubstrate binding site; other site
591020004117	catalytic site [active]
591020004118	SEC-C motif; Region: SEC-C; pfam02810
591020004119	hypothetical protein; Provisional; Region: PRK04233
591020004120	hypothetical protein; Provisional; Region: PRK10279
591020004121	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
591020004122	active site
591020004123	nucleophile elbow; other site
591020004124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020004125	active site
591020004126	response regulator of RpoS; Provisional; Region: PRK10693
591020004127	phosphorylation site [posttranslational modification]
591020004128	intermolecular recognition site; other site
591020004129	dimerization interface [polypeptide binding]; other site
591020004130	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
591020004131	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
591020004132	active site
591020004133	tetramer interface; other site
591020004134	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
591020004135	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
591020004136	thymidine kinase; Provisional; Region: PRK04296
591020004137	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020004138	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020004139	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020004140	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
591020004141	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
591020004142	putative catalytic cysteine [active]
591020004143	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
591020004144	putative active site [active]
591020004145	metal binding site [ion binding]; metal-binding site
591020004146	hypothetical protein; Provisional; Region: PRK11111
591020004147	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004148	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
591020004149	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591020004150	peptide binding site [polypeptide binding]; other site
591020004151	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
591020004152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020004153	dimer interface [polypeptide binding]; other site
591020004154	conserved gate region; other site
591020004155	putative PBP binding loops; other site
591020004156	ABC-ATPase subunit interface; other site
591020004157	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
591020004158	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591020004159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020004160	dimer interface [polypeptide binding]; other site
591020004161	conserved gate region; other site
591020004162	putative PBP binding loops; other site
591020004163	ABC-ATPase subunit interface; other site
591020004164	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
591020004165	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020004166	Walker A/P-loop; other site
591020004167	ATP binding site [chemical binding]; other site
591020004168	Q-loop/lid; other site
591020004169	ABC transporter signature motif; other site
591020004170	Walker B; other site
591020004171	D-loop; other site
591020004172	H-loop/switch region; other site
591020004173	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591020004174	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
591020004175	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020004176	Walker A/P-loop; other site
591020004177	ATP binding site [chemical binding]; other site
591020004178	Q-loop/lid; other site
591020004179	ABC transporter signature motif; other site
591020004180	Walker B; other site
591020004181	D-loop; other site
591020004182	H-loop/switch region; other site
591020004183	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591020004184	dsDNA-mimic protein; Reviewed; Region: PRK05094
591020004185	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
591020004186	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
591020004187	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
591020004188	putative active site [active]
591020004189	catalytic site [active]
591020004190	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
591020004191	putative active site [active]
591020004192	catalytic site [active]
591020004193	voltage-gated potassium channel; Provisional; Region: PRK10537
591020004194	Ion channel; Region: Ion_trans_2; pfam07885
591020004195	TrkA-N domain; Region: TrkA_N; pfam02254
591020004196	putative transposase OrfB; Reviewed; Region: PHA02517
591020004197	Integrase core domain; Region: rve; pfam00665
591020004198	Integrase core domain; Region: rve_3; pfam13683
591020004199	YciI-like protein; Reviewed; Region: PRK11370
591020004200	transport protein TonB; Provisional; Region: PRK10819
591020004201	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
591020004202	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
591020004203	intracellular septation protein A; Reviewed; Region: PRK00259
591020004204	hypothetical protein; Provisional; Region: PRK02868
591020004205	outer membrane protein W; Provisional; Region: PRK10959
591020004206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
591020004207	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
591020004208	dimerization interface [polypeptide binding]; other site
591020004209	metal binding site [ion binding]; metal-binding site
591020004210	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
591020004211	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
591020004212	substrate binding site [chemical binding]; other site
591020004213	active site
591020004214	catalytic residues [active]
591020004215	heterodimer interface [polypeptide binding]; other site
591020004216	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
591020004217	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
591020004218	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020004219	catalytic residue [active]
591020004220	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
591020004221	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
591020004222	active site
591020004223	ribulose/triose binding site [chemical binding]; other site
591020004224	phosphate binding site [ion binding]; other site
591020004225	substrate (anthranilate) binding pocket [chemical binding]; other site
591020004226	product (indole) binding pocket [chemical binding]; other site
591020004227	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
591020004228	active site
591020004229	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
591020004230	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
591020004231	glutamine binding [chemical binding]; other site
591020004232	catalytic triad [active]
591020004233	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
591020004234	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
591020004235	anthranilate synthase component I; Provisional; Region: PRK13564
591020004236	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
591020004237	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
591020004238	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
591020004239	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
591020004240	active site
591020004241	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
591020004242	hypothetical protein; Provisional; Region: PRK11630
591020004243	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
591020004244	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020004245	RNA binding surface [nucleotide binding]; other site
591020004246	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
591020004247	probable active site [active]
591020004248	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
591020004249	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
591020004250	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
591020004251	homodimer interface [polypeptide binding]; other site
591020004252	Walker A motif; other site
591020004253	ATP binding site [chemical binding]; other site
591020004254	hydroxycobalamin binding site [chemical binding]; other site
591020004255	Walker B motif; other site
591020004256	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
591020004257	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
591020004258	NADP binding site [chemical binding]; other site
591020004259	homodimer interface [polypeptide binding]; other site
591020004260	active site
591020004261	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
591020004262	putative inner membrane peptidase; Provisional; Region: PRK11778
591020004263	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
591020004264	tandem repeat interface [polypeptide binding]; other site
591020004265	oligomer interface [polypeptide binding]; other site
591020004266	active site residues [active]
591020004267	hypothetical protein; Provisional; Region: PRK11037
591020004268	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
591020004269	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
591020004270	active site
591020004271	interdomain interaction site; other site
591020004272	putative metal-binding site [ion binding]; other site
591020004273	nucleotide binding site [chemical binding]; other site
591020004274	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
591020004275	domain I; other site
591020004276	DNA binding groove [nucleotide binding]
591020004277	phosphate binding site [ion binding]; other site
591020004278	domain II; other site
591020004279	domain III; other site
591020004280	nucleotide binding site [chemical binding]; other site
591020004281	catalytic site [active]
591020004282	domain IV; other site
591020004283	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591020004284	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591020004285	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
591020004286	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
591020004287	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
591020004288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020004289	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
591020004290	substrate binding site [chemical binding]; other site
591020004291	putative dimerization interface [polypeptide binding]; other site
591020004292	aconitate hydratase; Validated; Region: PRK09277
591020004293	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
591020004294	substrate binding site [chemical binding]; other site
591020004295	ligand binding site [chemical binding]; other site
591020004296	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
591020004297	substrate binding site [chemical binding]; other site
591020004298	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
591020004299	dimerization interface [polypeptide binding]; other site
591020004300	active site
591020004301	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591020004302	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
591020004303	active site
591020004304	Predicted membrane protein [Function unknown]; Region: COG3771
591020004305	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
591020004306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
591020004307	TPR motif; other site
591020004308	binding surface
591020004309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591020004310	binding surface
591020004311	TPR motif; other site
591020004312	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
591020004313	active site
591020004314	dimer interface [polypeptide binding]; other site
591020004315	translation initiation factor Sui1; Validated; Region: PRK06824
591020004316	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
591020004317	putative rRNA binding site [nucleotide binding]; other site
591020004318	lipoprotein; Provisional; Region: PRK10540
591020004319	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591020004320	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591020004321	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020004322	hypothetical protein; Provisional; Region: PRK13658
591020004323	exoribonuclease II; Provisional; Region: PRK05054
591020004324	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
591020004325	RNB domain; Region: RNB; pfam00773
591020004326	S1 RNA binding domain; Region: S1; pfam00575
591020004327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
591020004328	Uncharacterized conserved protein [Function unknown]; Region: COG2128
591020004329	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
591020004330	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
591020004331	NAD binding site [chemical binding]; other site
591020004332	homotetramer interface [polypeptide binding]; other site
591020004333	homodimer interface [polypeptide binding]; other site
591020004334	substrate binding site [chemical binding]; other site
591020004335	active site
591020004336	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
591020004337	putative active site [active]
591020004338	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
591020004339	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020004340	Walker A/P-loop; other site
591020004341	ATP binding site [chemical binding]; other site
591020004342	Q-loop/lid; other site
591020004343	ABC transporter signature motif; other site
591020004344	Walker B; other site
591020004345	D-loop; other site
591020004346	H-loop/switch region; other site
591020004347	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
591020004348	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020004349	Walker A/P-loop; other site
591020004350	ATP binding site [chemical binding]; other site
591020004351	Q-loop/lid; other site
591020004352	ABC transporter signature motif; other site
591020004353	Walker B; other site
591020004354	D-loop; other site
591020004355	H-loop/switch region; other site
591020004356	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591020004357	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
591020004358	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591020004359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020004360	dimer interface [polypeptide binding]; other site
591020004361	conserved gate region; other site
591020004362	putative PBP binding loops; other site
591020004363	ABC-ATPase subunit interface; other site
591020004364	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
591020004365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020004366	dimer interface [polypeptide binding]; other site
591020004367	conserved gate region; other site
591020004368	putative PBP binding loops; other site
591020004369	ABC-ATPase subunit interface; other site
591020004370	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
591020004371	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
591020004372	peptide binding site [polypeptide binding]; other site
591020004373	Protein of unknown function (DUF2543); Region: DUF2543; pfam10820
591020004374	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
591020004375	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
591020004376	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
591020004377	gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366
591020004378	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
591020004379	catalytic triad [active]
591020004380	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
591020004381	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020004382	non-specific DNA binding site [nucleotide binding]; other site
591020004383	salt bridge; other site
591020004384	sequence-specific DNA binding site [nucleotide binding]; other site
591020004385	Cupin domain; Region: Cupin_2; pfam07883
591020004386	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
591020004387	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
591020004388	NAD(P) binding site [chemical binding]; other site
591020004389	catalytic residues [active]
591020004390	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
591020004391	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
591020004392	4-aminobutyrate transaminase; Provisional; Region: PRK09792
591020004393	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591020004394	inhibitor-cofactor binding pocket; inhibition site
591020004395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020004396	catalytic residue [active]
591020004397	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
591020004398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020004399	Walker A motif; other site
591020004400	ATP binding site [chemical binding]; other site
591020004401	Walker B motif; other site
591020004402	arginine finger; other site
591020004403	phage shock protein PspA; Provisional; Region: PRK10698
591020004404	phage shock protein B; Provisional; Region: pspB; PRK09458
591020004405	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
591020004406	phage shock protein C; Region: phageshock_pspC; TIGR02978
591020004407	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
591020004408	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
591020004409	active site residue [active]
591020004410	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
591020004411	active site
591020004412	catalytic site [active]
591020004413	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004414	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
591020004415	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
591020004416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020004417	dimer interface [polypeptide binding]; other site
591020004418	conserved gate region; other site
591020004419	putative PBP binding loops; other site
591020004420	ABC-ATPase subunit interface; other site
591020004421	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591020004422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020004423	dimer interface [polypeptide binding]; other site
591020004424	conserved gate region; other site
591020004425	putative PBP binding loops; other site
591020004426	ABC-ATPase subunit interface; other site
591020004427	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591020004428	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
591020004429	putative NAD(P) binding site [chemical binding]; other site
591020004430	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
591020004431	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
591020004432	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
591020004433	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
591020004434	beta-phosphoglucomutase; Region: bPGM; TIGR01990
591020004435	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020004436	motif II; other site
591020004437	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
591020004438	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
591020004439	Walker A/P-loop; other site
591020004440	ATP binding site [chemical binding]; other site
591020004441	Q-loop/lid; other site
591020004442	ABC transporter signature motif; other site
591020004443	Walker B; other site
591020004444	D-loop; other site
591020004445	H-loop/switch region; other site
591020004446	TOBE domain; Region: TOBE_2; pfam08402
591020004447	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591020004448	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020004449	DNA binding site [nucleotide binding]
591020004450	domain linker motif; other site
591020004451	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
591020004452	putative dimerization interface [polypeptide binding]; other site
591020004453	putative ligand binding site [chemical binding]; other site
591020004454	Predicted ATPase [General function prediction only]; Region: COG3106
591020004455	Predicted membrane protein [Function unknown]; Region: COG3768
591020004456	TIGR01620 family protein; Region: hyp_HI0043
591020004457	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
591020004458	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
591020004459	putative aromatic amino acid binding site; other site
591020004460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020004461	Walker A motif; other site
591020004462	ATP binding site [chemical binding]; other site
591020004463	Walker B motif; other site
591020004464	arginine finger; other site
591020004465	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
591020004466	dimer interface [polypeptide binding]; other site
591020004467	catalytic triad [active]
591020004468	peroxidatic and resolving cysteines [active]
591020004469	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
591020004470	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
591020004471	active site
591020004472	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
591020004473	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
591020004474	putative active site [active]
591020004475	Zn binding site [ion binding]; other site
591020004476	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
591020004477	NADH(P)-binding; Region: NAD_binding_10; pfam13460
591020004478	putative NAD(P) binding site [chemical binding]; other site
591020004479	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020004480	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020004481	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591020004482	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020004483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020004484	dimerization interface [polypeptide binding]; other site
591020004485	putative transposase OrfB; Reviewed; Region: PHA02517
591020004486	Integrase core domain; Region: rve; pfam00665
591020004487	Integrase core domain; Region: rve_3; pfam13683
591020004488	HTH-like domain; Region: HTH_21; pfam13276
591020004489	Integrase core domain; Region: rve; pfam00665
591020004490	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020004491	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020004492	primosomal protein DnaI; Provisional; Region: PRK02854
591020004493	putative replication protein; Provisional; Region: PRK12377
591020004494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020004495	Walker A motif; other site
591020004496	ATP binding site [chemical binding]; other site
591020004497	Walker B motif; other site
591020004498	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
591020004499	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
591020004500	active site
591020004501	Protein of unknown function (DUF551); Region: DUF551; pfam04448
591020004502	Hok/gef family; Region: HOK_GEF; pfam01848
591020004503	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004504	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
591020004505	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
591020004506	Protein of unknown function (DUF1133); Region: DUF1133; pfam06576
591020004507	Ash protein family; Region: Phage_ASH; pfam10554
591020004508	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020004509	Transposase; Region: HTH_Tnp_1; pfam01527
591020004510	putative transposase OrfB; Reviewed; Region: PHA02517
591020004511	Integrase core domain; Region: rve; pfam00665
591020004512	Integrase core domain; Region: rve_3; pfam13683
591020004513	ORF6N domain; Region: ORF6N; pfam10543
591020004514	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
591020004515	Int/Topo IB signature motif; other site
591020004516	Integrase core domain; Region: rve; pfam00665
591020004517	Integrase core domain; Region: rve_3; pfam13683
591020004518	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
591020004519	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004520	putative transposase OrfB; Reviewed; Region: PHA02517
591020004521	Integrase core domain; Region: rve; pfam00665
591020004522	Integrase core domain; Region: rve_3; pfam13683
591020004523	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591020004524	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
591020004525	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591020004526	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020004527	ABC-ATPase subunit  interface; other site
591020004528	dimer interface [polypeptide binding]; other site
591020004529	putative PBP binding regions; other site
591020004530	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591020004531	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020004532	ABC-ATPase subunit  interface; other site
591020004533	dimer interface [polypeptide binding]; other site
591020004534	putative PBP binding regions; other site
591020004535	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
591020004536	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
591020004537	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
591020004538	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
591020004539	metal binding site [ion binding]; metal-binding site
591020004540	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
591020004541	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
591020004542	Int/Topo IB signature motif; other site
591020004543	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004544	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
591020004545	HTH-like domain; Region: HTH_21; pfam13276
591020004546	Integrase core domain; Region: rve; pfam00665
591020004547	Integrase core domain; Region: rve_3; pfam13683
591020004548	Transposase; Region: HTH_Tnp_1; cl17663
591020004549	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020004550	AAA domain; Region: AAA_24; pfam13479
591020004551	Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064
591020004552	putative transposase OrfB; Reviewed; Region: PHA02517
591020004553	Integrase core domain; Region: rve; pfam00665
591020004554	Integrase core domain; Region: rve_3; pfam13683
591020004555	exonuclease VIII; Reviewed; Region: PRK09709
591020004556	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
591020004557	hypothetical protein; Reviewed; Region: PRK09790
591020004558	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
591020004559	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020004560	HTH-like domain; Region: HTH_21; pfam13276
591020004561	Integrase core domain; Region: rve; pfam00665
591020004562	Integrase core domain; Region: rve_3; pfam13683
591020004563	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020004564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020004565	Ash protein family; Region: Phage_ASH; pfam10554
591020004566	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
591020004567	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
591020004568	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020004569	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591020004570	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591020004571	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
591020004572	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004573	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
591020004574	putative transposase OrfB; Reviewed; Region: PHA02517
591020004575	Integrase core domain; Region: rve; pfam00665
591020004576	Integrase core domain; Region: rve_3; pfam13683
591020004577	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
591020004578	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
591020004579	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
591020004580	integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155
591020004581	Paraquat-inducible protein A; Region: PqiA; pfam04403
591020004582	Paraquat-inducible protein A; Region: PqiA; pfam04403
591020004583	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
591020004584	GAF domain; Region: GAF_2; pfam13185
591020004585	ProP expression regulator; Provisional; Region: PRK04950
591020004586	ProQ/FINO family; Region: ProQ; pfam04352
591020004587	carboxy-terminal protease; Provisional; Region: PRK11186
591020004588	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
591020004589	protein binding site [polypeptide binding]; other site
591020004590	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
591020004591	Catalytic dyad [active]
591020004592	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
591020004593	heat shock protein HtpX; Provisional; Region: PRK05457
591020004594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020004595	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020004596	putative substrate translocation pore; other site
591020004597	Predicted integral membrane protein [Function unknown]; Region: COG5521
591020004598	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
591020004599	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591020004600	dimerization interface [polypeptide binding]; other site
591020004601	putative Zn2+ binding site [ion binding]; other site
591020004602	putative DNA binding site [nucleotide binding]; other site
591020004603	Bacterial transcriptional regulator; Region: IclR; pfam01614
591020004604	YobH-like protein; Region: YobH; pfam13996
591020004605	PhoPQ regulatory protein; Provisional; Region: PRK10299
591020004606	YebO-like protein; Region: YebO; pfam13974
591020004607	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
591020004608	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591020004609	DNA-binding site [nucleotide binding]; DNA binding site
591020004610	RNA-binding motif; other site
591020004611	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
591020004612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020004613	S-adenosylmethionine binding site [chemical binding]; other site
591020004614	hypothetical protein; Provisional; Region: PRK11469
591020004615	Domain of unknown function DUF; Region: DUF204; pfam02659
591020004616	Domain of unknown function DUF; Region: DUF204; pfam02659
591020004617	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004618	Predicted membrane protein [Function unknown]; Region: COG4811
591020004619	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
591020004620	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
591020004621	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
591020004622	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591020004623	active pocket/dimerization site; other site
591020004624	active site
591020004625	phosphorylation site [posttranslational modification]
591020004626	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591020004627	active site
591020004628	phosphorylation site [posttranslational modification]
591020004629	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
591020004630	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
591020004631	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591020004632	Transporter associated domain; Region: CorC_HlyC; smart01091
591020004633	phage resistance protein; Provisional; Region: PRK10551
591020004634	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591020004635	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020004636	L-serine deaminase; Provisional; Region: PRK15023
591020004637	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
591020004638	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
591020004639	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
591020004640	putative active site [active]
591020004641	putative CoA binding site [chemical binding]; other site
591020004642	nudix motif; other site
591020004643	metal binding site [ion binding]; metal-binding site
591020004644	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
591020004645	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
591020004646	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
591020004647	hypothetical protein; Provisional; Region: PRK05114
591020004648	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
591020004649	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
591020004650	homotrimer interaction site [polypeptide binding]; other site
591020004651	putative active site [active]
591020004652	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
591020004653	DEAD/DEAH box helicase; Region: DEAD; pfam00270
591020004654	DEAD_2; Region: DEAD_2; pfam06733
591020004655	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
591020004656	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
591020004657	Glycoprotease family; Region: Peptidase_M22; pfam00814
591020004658	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
591020004659	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
591020004660	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
591020004661	acyl-activating enzyme (AAE) consensus motif; other site
591020004662	putative AMP binding site [chemical binding]; other site
591020004663	putative active site [active]
591020004664	putative CoA binding site [chemical binding]; other site
591020004665	ribonuclease D; Provisional; Region: PRK10829
591020004666	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
591020004667	catalytic site [active]
591020004668	putative active site [active]
591020004669	putative substrate binding site [chemical binding]; other site
591020004670	Helicase and RNase D C-terminal; Region: HRDC; smart00341
591020004671	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
591020004672	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
591020004673	FMN-binding pocket [chemical binding]; other site
591020004674	flavin binding motif; other site
591020004675	phosphate binding motif [ion binding]; other site
591020004676	beta-alpha-beta structure motif; other site
591020004677	NAD binding pocket [chemical binding]; other site
591020004678	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591020004679	catalytic loop [active]
591020004680	iron binding site [ion binding]; other site
591020004681	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
591020004682	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
591020004683	putative alpha subunit interface [polypeptide binding]; other site
591020004684	putative active site [active]
591020004685	putative substrate binding site [chemical binding]; other site
591020004686	Fe binding site [ion binding]; other site
591020004687	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
591020004688	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020004689	non-specific DNA binding site [nucleotide binding]; other site
591020004690	salt bridge; other site
591020004691	sequence-specific DNA binding site [nucleotide binding]; other site
591020004692	putative transposase OrfB; Reviewed; Region: PHA02517
591020004693	Integrase core domain; Region: rve; pfam00665
591020004694	Integrase core domain; Region: rve_3; pfam13683
591020004695	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
591020004696	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591020004697	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591020004698	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020004699	metal binding site [ion binding]; metal-binding site
591020004700	active site
591020004701	I-site; other site
591020004702	Uncharacterized conserved protein [Function unknown]; Region: COG3189
591020004703	cyanate transporter; Region: CynX; TIGR00896
591020004704	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020004705	putative substrate translocation pore; other site
591020004706	Predicted membrane protein [Function unknown]; Region: COG2707
591020004707	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
591020004708	putative deacylase active site [active]
591020004709	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591020004710	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020004711	metal binding site [ion binding]; metal-binding site
591020004712	active site
591020004713	putative transposase OrfB; Reviewed; Region: PHA02517
591020004714	Integrase core domain; Region: rve; pfam00665
591020004715	Integrase core domain; Region: rve_3; pfam13683
591020004716	PrkA AAA domain; Region: AAA_PrkA; pfam08298
591020004717	AAA ATPase domain; Region: AAA_16; pfam13191
591020004718	Walker A motif; other site
591020004719	ATP binding site [chemical binding]; other site
591020004720	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
591020004721	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
591020004722	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020004723	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020004724	active site
591020004725	catalytic tetrad [active]
591020004726	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
591020004727	active site
591020004728	phosphate binding residues; other site
591020004729	catalytic residues [active]
591020004730	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
591020004731	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
591020004732	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
591020004733	methionine sulfoxide reductase B; Provisional; Region: PRK00222
591020004734	SelR domain; Region: SelR; pfam01641
591020004735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
591020004736	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591020004737	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
591020004738	putative NAD(P) binding site [chemical binding]; other site
591020004739	catalytic Zn binding site [ion binding]; other site
591020004740	structural Zn binding site [ion binding]; other site
591020004741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020004742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020004743	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591020004744	intersubunit interface [polypeptide binding]; other site
591020004745	active site
591020004746	zinc binding site [ion binding]; other site
591020004747	Na+ binding site [ion binding]; other site
591020004748	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020004749	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
591020004750	substrate binding site [chemical binding]; other site
591020004751	ATP binding site [chemical binding]; other site
591020004752	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020004753	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020004754	active site
591020004755	catalytic tetrad [active]
591020004756	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591020004757	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591020004758	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020004759	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
591020004760	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020004761	putative substrate translocation pore; other site
591020004762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020004763	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
591020004764	Isochorismatase family; Region: Isochorismatase; pfam00857
591020004765	catalytic triad [active]
591020004766	metal binding site [ion binding]; metal-binding site
591020004767	conserved cis-peptide bond; other site
591020004768	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
591020004769	active site
591020004770	homodimer interface [polypeptide binding]; other site
591020004771	protease 4; Provisional; Region: PRK10949
591020004772	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
591020004773	tandem repeat interface [polypeptide binding]; other site
591020004774	oligomer interface [polypeptide binding]; other site
591020004775	active site residues [active]
591020004776	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
591020004777	tandem repeat interface [polypeptide binding]; other site
591020004778	oligomer interface [polypeptide binding]; other site
591020004779	active site residues [active]
591020004780	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
591020004781	putative FMN binding site [chemical binding]; other site
591020004782	selenophosphate synthetase; Provisional; Region: PRK00943
591020004783	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
591020004784	dimerization interface [polypeptide binding]; other site
591020004785	putative ATP binding site [chemical binding]; other site
591020004786	DNA topoisomerase III; Provisional; Region: PRK07726
591020004787	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
591020004788	active site
591020004789	putative interdomain interaction site [polypeptide binding]; other site
591020004790	putative metal-binding site [ion binding]; other site
591020004791	putative nucleotide binding site [chemical binding]; other site
591020004792	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
591020004793	domain I; other site
591020004794	DNA binding groove [nucleotide binding]
591020004795	phosphate binding site [ion binding]; other site
591020004796	domain II; other site
591020004797	domain III; other site
591020004798	nucleotide binding site [chemical binding]; other site
591020004799	catalytic site [active]
591020004800	domain IV; other site
591020004801	hypothetical protein; Provisional; Region: PRK11380
591020004802	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
591020004803	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
591020004804	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
591020004805	NAD(P) binding site [chemical binding]; other site
591020004806	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020004807	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020004808	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020004809	HTH-like domain; Region: HTH_21; pfam13276
591020004810	Integrase core domain; Region: rve; pfam00665
591020004811	Integrase core domain; Region: rve_3; pfam13683
591020004812	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
591020004813	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
591020004814	active site
591020004815	8-oxo-dGMP binding site [chemical binding]; other site
591020004816	nudix motif; other site
591020004817	metal binding site [ion binding]; metal-binding site
591020004818	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
591020004819	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
591020004820	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020004821	Walker A/P-loop; other site
591020004822	ATP binding site [chemical binding]; other site
591020004823	Q-loop/lid; other site
591020004824	ABC transporter signature motif; other site
591020004825	Walker B; other site
591020004826	D-loop; other site
591020004827	H-loop/switch region; other site
591020004828	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020004829	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020004830	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020004831	Uncharacterized conserved protein [Function unknown]; Region: COG2128
591020004832	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
591020004833	Uncharacterized conserved protein [Function unknown]; Region: COG0398
591020004834	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591020004835	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
591020004836	putative catalytic site [active]
591020004837	putative phosphate binding site [ion binding]; other site
591020004838	active site
591020004839	metal binding site A [ion binding]; metal-binding site
591020004840	DNA binding site [nucleotide binding]
591020004841	putative AP binding site [nucleotide binding]; other site
591020004842	putative metal binding site B [ion binding]; other site
591020004843	arginine succinyltransferase; Provisional; Region: PRK10456
591020004844	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
591020004845	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
591020004846	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
591020004847	NAD(P) binding site [chemical binding]; other site
591020004848	catalytic residues [active]
591020004849	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
591020004850	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
591020004851	putative active site [active]
591020004852	Zn binding site [ion binding]; other site
591020004853	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
591020004854	dimer interface [polypeptide binding]; other site
591020004855	hypothetical protein; Provisional; Region: PRK11396
591020004856	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
591020004857	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
591020004858	GIY-YIG motif/motif A; other site
591020004859	active site
591020004860	catalytic site [active]
591020004861	putative DNA binding site [nucleotide binding]; other site
591020004862	metal binding site [ion binding]; metal-binding site
591020004863	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
591020004864	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
591020004865	homodimer interface [polypeptide binding]; other site
591020004866	NAD binding pocket [chemical binding]; other site
591020004867	ATP binding pocket [chemical binding]; other site
591020004868	Mg binding site [ion binding]; other site
591020004869	active-site loop [active]
591020004870	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
591020004871	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
591020004872	active site
591020004873	P-loop; other site
591020004874	phosphorylation site [posttranslational modification]
591020004875	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
591020004876	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
591020004877	methionine cluster; other site
591020004878	active site
591020004879	phosphorylation site [posttranslational modification]
591020004880	metal binding site [ion binding]; metal-binding site
591020004881	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
591020004882	Cupin domain; Region: Cupin_2; pfam07883
591020004883	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004884	inner membrane protein; Provisional; Region: PRK11648
591020004885	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
591020004886	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591020004887	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020004888	motif II; other site
591020004889	YniB-like protein; Region: YniB; pfam14002
591020004890	Phosphotransferase enzyme family; Region: APH; pfam01636
591020004891	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
591020004892	active site
591020004893	ATP binding site [chemical binding]; other site
591020004894	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
591020004895	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
591020004896	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
591020004897	putative ATP binding site [chemical binding]; other site
591020004898	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
591020004899	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
591020004900	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004901	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
591020004902	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
591020004903	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
591020004904	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
591020004905	active site
591020004906	dimer interface [polypeptide binding]; other site
591020004907	motif 1; other site
591020004908	motif 2; other site
591020004909	motif 3; other site
591020004910	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
591020004911	anticodon binding site; other site
591020004912	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
591020004913	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
591020004914	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
591020004915	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
591020004916	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
591020004917	23S rRNA binding site [nucleotide binding]; other site
591020004918	L21 binding site [polypeptide binding]; other site
591020004919	L13 binding site [polypeptide binding]; other site
591020004920	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
591020004921	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
591020004922	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
591020004923	dimer interface [polypeptide binding]; other site
591020004924	motif 1; other site
591020004925	active site
591020004926	motif 2; other site
591020004927	motif 3; other site
591020004928	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
591020004929	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
591020004930	putative tRNA-binding site [nucleotide binding]; other site
591020004931	B3/4 domain; Region: B3_4; pfam03483
591020004932	tRNA synthetase B5 domain; Region: B5; smart00874
591020004933	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
591020004934	dimer interface [polypeptide binding]; other site
591020004935	motif 1; other site
591020004936	motif 3; other site
591020004937	motif 2; other site
591020004938	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
591020004939	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591020004940	IHF dimer interface [polypeptide binding]; other site
591020004941	IHF - DNA interface [nucleotide binding]; other site
591020004942	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
591020004943	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020004944	ABC-ATPase subunit  interface; other site
591020004945	dimer interface [polypeptide binding]; other site
591020004946	putative PBP binding regions; other site
591020004947	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
591020004948	catalytic residues [active]
591020004949	dimer interface [polypeptide binding]; other site
591020004950	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
591020004951	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
591020004952	Walker A/P-loop; other site
591020004953	ATP binding site [chemical binding]; other site
591020004954	Q-loop/lid; other site
591020004955	ABC transporter signature motif; other site
591020004956	Walker B; other site
591020004957	D-loop; other site
591020004958	H-loop/switch region; other site
591020004959	NlpC/P60 family; Region: NLPC_P60; pfam00877
591020004960	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
591020004961	hypothetical protein; Validated; Region: PRK00029
591020004962	Uncharacterized conserved protein [Function unknown]; Region: COG0397
591020004963	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
591020004964	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
591020004965	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591020004966	PEP synthetase regulatory protein; Provisional; Region: PRK05339
591020004967	phosphoenolpyruvate synthase; Validated; Region: PRK06464
591020004968	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
591020004969	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591020004970	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591020004971	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
591020004972	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
591020004973	acyl-activating enzyme (AAE) consensus motif; other site
591020004974	putative AMP binding site [chemical binding]; other site
591020004975	putative active site [active]
591020004976	putative CoA binding site [chemical binding]; other site
591020004977	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
591020004978	oxidoreductase; Provisional; Region: PRK10015
591020004979	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
591020004980	Electron transfer flavoprotein domain; Region: ETF; smart00893
591020004981	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
591020004982	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
591020004983	Ligand binding site [chemical binding]; other site
591020004984	Electron transfer flavoprotein domain; Region: ETF; pfam01012
591020004985	Cupin domain; Region: Cupin_2; pfam07883
591020004986	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004987	transcriptional regulator YdeO; Provisional; Region: PRK09940
591020004988	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020004989	putative oxidoreductase; Provisional; Region: PRK09939
591020004990	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
591020004991	putative molybdopterin cofactor binding site [chemical binding]; other site
591020004992	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
591020004993	putative molybdopterin cofactor binding site; other site
591020004994	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
591020004995	mannosyl binding site [chemical binding]; other site
591020004996	Fimbrial protein; Region: Fimbrial; pfam00419
591020004997	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020004998	putative transposase OrfB; Reviewed; Region: PHA02517
591020004999	Integrase core domain; Region: rve; pfam00665
591020005000	Integrase core domain; Region: rve_3; pfam13683
591020005001	Lysis protein S; Region: Lysis_S; pfam04971
591020005002	anti-adapter protein IraM; Provisional; Region: PRK09919
591020005003	Antitermination protein; Region: Antiterm; pfam03589
591020005004	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
591020005005	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
591020005006	Protein of unknown function (DUF968); Region: DUF968; pfam06147
591020005007	Hok/gef family; Region: HOK_GEF; pfam01848
591020005008	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
591020005009	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
591020005010	putative transposase OrfB; Reviewed; Region: PHA02517
591020005011	HTH-like domain; Region: HTH_21; pfam13276
591020005012	Integrase core domain; Region: rve; pfam00665
591020005013	Integrase core domain; Region: rve_3; pfam13683
591020005014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005015	putative substrate translocation pore; other site
591020005016	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
591020005017	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591020005018	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591020005019	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
591020005020	Transcriptional regulators [Transcription]; Region: GntR; COG1802
591020005021	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020005022	DNA-binding site [nucleotide binding]; DNA binding site
591020005023	FCD domain; Region: FCD; pfam07729
591020005024	malonic semialdehyde reductase; Provisional; Region: PRK10538
591020005025	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
591020005026	putative NAD(P) binding site [chemical binding]; other site
591020005027	homodimer interface [polypeptide binding]; other site
591020005028	homotetramer interface [polypeptide binding]; other site
591020005029	active site
591020005030	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
591020005031	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
591020005032	active site
591020005033	Zn binding site [ion binding]; other site
591020005034	hypothetical protein; Validated; Region: PRK03657
591020005035	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
591020005036	putative transposase OrfB; Reviewed; Region: PHA02517
591020005037	Integrase core domain; Region: rve; pfam00665
591020005038	Integrase core domain; Region: rve_3; pfam13683
591020005039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005040	putative substrate translocation pore; other site
591020005041	putative transporter; Provisional; Region: PRK10054
591020005042	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
591020005043	EamA-like transporter family; Region: EamA; pfam00892
591020005044	EamA-like transporter family; Region: EamA; pfam00892
591020005045	hypothetical protein; Provisional; Region: PRK10106
591020005046	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
591020005047	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020005048	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
591020005049	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591020005050	inner membrane protein; Provisional; Region: PRK10995
591020005051	putative arabinose transporter; Provisional; Region: PRK03545
591020005052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005053	putative substrate translocation pore; other site
591020005054	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
591020005055	NAD(P) binding site [chemical binding]; other site
591020005056	catalytic residues [active]
591020005057	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
591020005058	glutaminase; Provisional; Region: PRK00971
591020005059	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
591020005060	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591020005061	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020005062	metal binding site [ion binding]; metal-binding site
591020005063	active site
591020005064	I-site; other site
591020005065	altronate oxidoreductase; Provisional; Region: PRK03643
591020005066	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591020005067	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591020005068	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020005069	Putative transposase; Region: Y2_Tnp; pfam04986
591020005070	Predicted membrane protein [Function unknown]; Region: COG3781
591020005071	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
591020005072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020005073	S-adenosylmethionine binding site [chemical binding]; other site
591020005074	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
591020005075	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
591020005076	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
591020005077	putative active site; other site
591020005078	catalytic residue [active]
591020005079	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020005080	HTH-like domain; Region: HTH_21; pfam13276
591020005081	Integrase core domain; Region: rve; pfam00665
591020005082	Integrase core domain; Region: rve_3; pfam13683
591020005083	Transposase; Region: HTH_Tnp_1; cl17663
591020005084	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
591020005085	nucleotide binding site [chemical binding]; other site
591020005086	transcriptional regulator LsrR; Provisional; Region: PRK15418
591020005087	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
591020005088	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
591020005089	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
591020005090	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591020005091	Walker A/P-loop; other site
591020005092	ATP binding site [chemical binding]; other site
591020005093	Q-loop/lid; other site
591020005094	ABC transporter signature motif; other site
591020005095	Walker B; other site
591020005096	D-loop; other site
591020005097	H-loop/switch region; other site
591020005098	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591020005099	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020005100	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020005101	TM-ABC transporter signature motif; other site
591020005102	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020005103	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020005104	TM-ABC transporter signature motif; other site
591020005105	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020005106	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020005107	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020005108	HTH-like domain; Region: HTH_21; pfam13276
591020005109	Integrase core domain; Region: rve; pfam00665
591020005110	Integrase core domain; Region: rve_3; pfam13683
591020005111	putative transposase OrfB; Reviewed; Region: PHA02517
591020005112	HTH-like domain; Region: HTH_21; pfam13276
591020005113	Integrase core domain; Region: rve; pfam00665
591020005114	Integrase core domain; Region: rve_2; pfam13333
591020005115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020005116	Transposase; Region: HTH_Tnp_1; pfam01527
591020005117	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
591020005118	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
591020005119	putative active site pocket [active]
591020005120	putative metal binding site [ion binding]; other site
591020005121	hypothetical protein; Provisional; Region: PRK02237
591020005122	hypothetical protein; Provisional; Region: PRK13659
591020005123	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020005124	Coenzyme A binding pocket [chemical binding]; other site
591020005125	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
591020005126	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
591020005127	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
591020005128	Protein of unknown function (DUF1682); Region: DUF1682; pfam07946
591020005129	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
591020005130	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020005131	active site
591020005132	DNA binding site [nucleotide binding]
591020005133	Int/Topo IB signature motif; other site
591020005134	putative transposase OrfB; Reviewed; Region: PHA02517
591020005135	HTH-like domain; Region: HTH_21; pfam13276
591020005136	Integrase core domain; Region: rve; pfam00665
591020005137	Integrase core domain; Region: rve_3; pfam13683
591020005138	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
591020005139	molybdopterin cofactor binding site; other site
591020005140	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
591020005141	4Fe-4S binding domain; Region: Fer4; cl02805
591020005142	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
591020005143	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
591020005144	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591020005145	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
591020005146	Cl- selectivity filter; other site
591020005147	Cl- binding residues [ion binding]; other site
591020005148	pore gating glutamate residue; other site
591020005149	dimer interface [polypeptide binding]; other site
591020005150	putative dithiobiotin synthetase; Provisional; Region: PRK12374
591020005151	AAA domain; Region: AAA_26; pfam13500
591020005152	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
591020005153	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591020005154	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591020005155	nucleotide binding site [chemical binding]; other site
591020005156	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
591020005157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020005158	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
591020005159	dimerization interface [polypeptide binding]; other site
591020005160	substrate binding pocket [chemical binding]; other site
591020005161	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
591020005162	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
591020005163	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
591020005164	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
591020005165	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591020005166	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
591020005167	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
591020005168	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
591020005169	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
591020005170	ligand binding site [chemical binding]; other site
591020005171	homodimer interface [polypeptide binding]; other site
591020005172	NAD(P) binding site [chemical binding]; other site
591020005173	trimer interface B [polypeptide binding]; other site
591020005174	trimer interface A [polypeptide binding]; other site
591020005175	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
591020005176	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591020005177	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591020005178	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591020005179	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
591020005180	Spore germination protein; Region: Spore_permease; cl17796
591020005181	dihydromonapterin reductase; Provisional; Region: PRK06483
591020005182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591020005183	NAD(P) binding site [chemical binding]; other site
591020005184	active site
591020005185	GlpM protein; Region: GlpM; pfam06942
591020005186	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
591020005187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020005188	active site
591020005189	phosphorylation site [posttranslational modification]
591020005190	intermolecular recognition site; other site
591020005191	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020005192	DNA binding site [nucleotide binding]
591020005193	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
591020005194	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591020005195	sensor protein RstB; Provisional; Region: PRK10604
591020005196	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020005197	dimerization interface [polypeptide binding]; other site
591020005198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020005199	dimer interface [polypeptide binding]; other site
591020005200	phosphorylation site [posttranslational modification]
591020005201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020005202	ATP binding site [chemical binding]; other site
591020005203	Mg2+ binding site [ion binding]; other site
591020005204	G-X-G motif; other site
591020005205	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
591020005206	fumarate hydratase; Reviewed; Region: fumC; PRK00485
591020005207	Class II fumarases; Region: Fumarase_classII; cd01362
591020005208	active site
591020005209	tetramer interface [polypeptide binding]; other site
591020005210	fumarate hydratase; Provisional; Region: PRK15389
591020005211	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
591020005212	Fumarase C-terminus; Region: Fumerase_C; pfam05683
591020005213	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
591020005214	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
591020005215	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
591020005216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
591020005217	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
591020005218	putative outer membrane porin protein; Provisional; Region: PRK11379
591020005219	beta-D-glucuronidase; Provisional; Region: PRK10150
591020005220	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
591020005221	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
591020005222	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
591020005223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591020005224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020005225	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
591020005226	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020005227	DNA binding site [nucleotide binding]
591020005228	domain linker motif; other site
591020005229	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
591020005230	putative dimerization interface [polypeptide binding]; other site
591020005231	putative ligand binding site [chemical binding]; other site
591020005232	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
591020005233	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
591020005234	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591020005235	active site turn [active]
591020005236	phosphorylation site [posttranslational modification]
591020005237	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
591020005238	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591020005239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020005240	homodimer interface [polypeptide binding]; other site
591020005241	catalytic residue [active]
591020005242	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
591020005243	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
591020005244	active site
591020005245	purine riboside binding site [chemical binding]; other site
591020005246	putative oxidoreductase; Provisional; Region: PRK11579
591020005247	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591020005248	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591020005249	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
591020005250	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
591020005251	electron transport complex protein RsxA; Provisional; Region: PRK05151
591020005252	electron transport complex protein RnfB; Provisional; Region: PRK05113
591020005253	Putative Fe-S cluster; Region: FeS; pfam04060
591020005254	4Fe-4S binding domain; Region: Fer4; pfam00037
591020005255	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
591020005256	SLBB domain; Region: SLBB; pfam10531
591020005257	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591020005258	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
591020005259	electron transport complex protein RnfG; Validated; Region: PRK01908
591020005260	electron transport complex RsxE subunit; Provisional; Region: PRK12405
591020005261	endonuclease III; Provisional; Region: PRK10702
591020005262	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
591020005263	minor groove reading motif; other site
591020005264	helix-hairpin-helix signature motif; other site
591020005265	substrate binding pocket [chemical binding]; other site
591020005266	active site
591020005267	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
591020005268	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
591020005269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005270	putative substrate translocation pore; other site
591020005271	POT family; Region: PTR2; pfam00854
591020005272	glutathionine S-transferase; Provisional; Region: PRK10542
591020005273	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
591020005274	C-terminal domain interface [polypeptide binding]; other site
591020005275	GSH binding site (G-site) [chemical binding]; other site
591020005276	dimer interface [polypeptide binding]; other site
591020005277	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
591020005278	N-terminal domain interface [polypeptide binding]; other site
591020005279	dimer interface [polypeptide binding]; other site
591020005280	substrate binding pocket (H-site) [chemical binding]; other site
591020005281	pyridoxamine kinase; Validated; Region: PRK05756
591020005282	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
591020005283	dimer interface [polypeptide binding]; other site
591020005284	pyridoxal binding site [chemical binding]; other site
591020005285	ATP binding site [chemical binding]; other site
591020005286	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
591020005287	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
591020005288	active site
591020005289	HIGH motif; other site
591020005290	dimer interface [polypeptide binding]; other site
591020005291	KMSKS motif; other site
591020005292	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020005293	RNA binding surface [nucleotide binding]; other site
591020005294	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
591020005295	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
591020005296	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
591020005297	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
591020005298	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020005299	HTH-like domain; Region: HTH_21; pfam13276
591020005300	Integrase core domain; Region: rve; pfam00665
591020005301	Integrase core domain; Region: rve_3; pfam13683
591020005302	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
591020005303	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
591020005304	transcriptional regulator SlyA; Provisional; Region: PRK03573
591020005305	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
591020005306	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
591020005307	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
591020005308	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020005309	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020005310	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
591020005311	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
591020005312	E-class dimer interface [polypeptide binding]; other site
591020005313	P-class dimer interface [polypeptide binding]; other site
591020005314	active site
591020005315	Cu2+ binding site [ion binding]; other site
591020005316	Zn2+ binding site [ion binding]; other site
591020005317	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020005318	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020005319	active site
591020005320	catalytic tetrad [active]
591020005321	Predicted Fe-S protein [General function prediction only]; Region: COG3313
591020005322	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591020005323	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020005324	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
591020005325	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
591020005326	FMN binding site [chemical binding]; other site
591020005327	active site
591020005328	substrate binding site [chemical binding]; other site
591020005329	catalytic residue [active]
591020005330	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591020005331	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
591020005332	dimer interface [polypeptide binding]; other site
591020005333	active site
591020005334	metal binding site [ion binding]; metal-binding site
591020005335	glutathione binding site [chemical binding]; other site
591020005336	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
591020005337	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
591020005338	dimer interface [polypeptide binding]; other site
591020005339	catalytic site [active]
591020005340	putative active site [active]
591020005341	putative substrate binding site [chemical binding]; other site
591020005342	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
591020005343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
591020005344	Probable transposase; Region: OrfB_IS605; pfam01385
591020005345	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
591020005346	Transposase IS200 like; Region: Y1_Tnp; pfam01797
591020005347	potential protein location (hypothetical protein) that overlaps protein (Transposase, IS605 family)
591020005348	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
591020005349	putative GSH binding site [chemical binding]; other site
591020005350	catalytic residues [active]
591020005351	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591020005352	NlpC/P60 family; Region: NLPC_P60; pfam00877
591020005353	superoxide dismutase; Provisional; Region: PRK10543
591020005354	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
591020005355	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
591020005356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005357	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020005358	putative substrate translocation pore; other site
591020005359	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
591020005360	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020005361	DNA binding site [nucleotide binding]
591020005362	domain linker motif; other site
591020005363	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
591020005364	dimerization interface [polypeptide binding]; other site
591020005365	ligand binding site [chemical binding]; other site
591020005366	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
591020005367	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020005368	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020005369	dimerization interface [polypeptide binding]; other site
591020005370	putative transporter; Provisional; Region: PRK11043
591020005371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005372	putative substrate translocation pore; other site
591020005373	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
591020005374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
591020005375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020005376	S-adenosylmethionine binding site [chemical binding]; other site
591020005377	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
591020005378	Lumazine binding domain; Region: Lum_binding; pfam00677
591020005379	Lumazine binding domain; Region: Lum_binding; pfam00677
591020005380	multidrug efflux protein; Reviewed; Region: PRK01766
591020005381	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
591020005382	cation binding site [ion binding]; other site
591020005383	hypothetical protein; Provisional; Region: PRK09945
591020005384	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
591020005385	putative monooxygenase; Provisional; Region: PRK11118
591020005386	hypothetical protein; Provisional; Region: PRK09897
591020005387	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
591020005388	hypothetical protein; Provisional; Region: PRK09946
591020005389	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
591020005390	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
591020005391	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
591020005392	hypothetical protein; Provisional; Region: PRK09947
591020005393	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
591020005394	hypothetical protein; Provisional; Region: PRK09898
591020005395	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591020005396	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005397	pyruvate kinase; Provisional; Region: PRK09206
591020005398	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
591020005399	active site
591020005400	domain interfaces; other site
591020005401	murein lipoprotein; Provisional; Region: PRK15396
591020005402	L,D-transpeptidase; Provisional; Region: PRK10190
591020005403	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020005404	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591020005405	cysteine desufuration protein SufE; Provisional; Region: PRK09296
591020005406	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
591020005407	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
591020005408	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591020005409	catalytic residue [active]
591020005410	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
591020005411	FeS assembly protein SufD; Region: sufD; TIGR01981
591020005412	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
591020005413	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
591020005414	Walker A/P-loop; other site
591020005415	ATP binding site [chemical binding]; other site
591020005416	Q-loop/lid; other site
591020005417	ABC transporter signature motif; other site
591020005418	Walker B; other site
591020005419	D-loop; other site
591020005420	H-loop/switch region; other site
591020005421	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
591020005422	putative ABC transporter; Region: ycf24; CHL00085
591020005423	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
591020005424	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
591020005425	CoenzymeA binding site [chemical binding]; other site
591020005426	subunit interaction site [polypeptide binding]; other site
591020005427	PHB binding site; other site
591020005428	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
591020005429	FAD binding domain; Region: FAD_binding_4; pfam01565
591020005430	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
591020005431	putative inner membrane protein; Provisional; Region: PRK10983
591020005432	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591020005433	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
591020005434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005435	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020005436	putative substrate translocation pore; other site
591020005437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005438	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020005439	putative substrate translocation pore; other site
591020005440	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
591020005441	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
591020005442	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
591020005443	shikimate binding site; other site
591020005444	NAD(P) binding site [chemical binding]; other site
591020005445	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
591020005446	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
591020005447	active site
591020005448	catalytic residue [active]
591020005449	dimer interface [polypeptide binding]; other site
591020005450	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005451	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
591020005452	Sulfatase; Region: Sulfatase; pfam00884
591020005453	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
591020005454	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020005455	FeS/SAM binding site; other site
591020005456	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
591020005457	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
591020005458	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
591020005459	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005460	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
591020005461	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
591020005462	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591020005463	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
591020005464	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591020005465	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005466	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
591020005467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020005468	catalytic residue [active]
591020005469	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
591020005470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
591020005471	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
591020005472	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
591020005473	heme-binding site [chemical binding]; other site
591020005474	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591020005475	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020005476	metal binding site [ion binding]; metal-binding site
591020005477	active site
591020005478	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020005479	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
591020005480	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
591020005481	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591020005482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020005483	dimer interface [polypeptide binding]; other site
591020005484	conserved gate region; other site
591020005485	putative PBP binding loops; other site
591020005486	ABC-ATPase subunit interface; other site
591020005487	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
591020005488	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020005489	Walker A/P-loop; other site
591020005490	ATP binding site [chemical binding]; other site
591020005491	Q-loop/lid; other site
591020005492	ABC transporter signature motif; other site
591020005493	Walker B; other site
591020005494	D-loop; other site
591020005495	H-loop/switch region; other site
591020005496	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
591020005497	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
591020005498	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
591020005499	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
591020005500	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
591020005501	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005502	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
591020005503	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
591020005504	NAD binding site [chemical binding]; other site
591020005505	substrate binding site [chemical binding]; other site
591020005506	catalytic Zn binding site [ion binding]; other site
591020005507	tetramer interface [polypeptide binding]; other site
591020005508	structural Zn binding site [ion binding]; other site
591020005509	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
591020005510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020005511	non-specific DNA binding site [nucleotide binding]; other site
591020005512	salt bridge; other site
591020005513	sequence-specific DNA binding site [nucleotide binding]; other site
591020005514	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
591020005515	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
591020005516	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
591020005517	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
591020005518	aromatic amino acid exporter; Provisional; Region: PRK11689
591020005519	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591020005520	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591020005521	trimer interface [polypeptide binding]; other site
591020005522	eyelet of channel; other site
591020005523	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
591020005524	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005525	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
591020005526	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
591020005527	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020005528	Putative transposase; Region: Y2_Tnp; pfam04986
591020005529	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
591020005530	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020005531	DNA-binding site [nucleotide binding]; DNA binding site
591020005532	FCD domain; Region: FCD; pfam07729
591020005533	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
591020005534	Prostaglandin dehydrogenases; Region: PGDH; cd05288
591020005535	NAD(P) binding site [chemical binding]; other site
591020005536	substrate binding site [chemical binding]; other site
591020005537	dimer interface [polypeptide binding]; other site
591020005538	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020005539	HTH-like domain; Region: HTH_21; pfam13276
591020005540	Integrase core domain; Region: rve; pfam00665
591020005541	Integrase core domain; Region: rve_3; pfam13683
591020005542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
591020005543	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
591020005544	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
591020005545	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
591020005546	trimer interface [polypeptide binding]; other site
591020005547	active site
591020005548	substrate binding site [chemical binding]; other site
591020005549	CoA binding site [chemical binding]; other site
591020005550	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
591020005551	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
591020005552	tetrameric interface [polypeptide binding]; other site
591020005553	NAD binding site [chemical binding]; other site
591020005554	catalytic residues [active]
591020005555	substrate binding site [chemical binding]; other site
591020005556	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591020005557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020005558	ABC-ATPase subunit interface; other site
591020005559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020005560	dimer interface [polypeptide binding]; other site
591020005561	ABC-ATPase subunit interface; other site
591020005562	putative PBP binding loops; other site
591020005563	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020005564	Putative transposase; Region: Y2_Tnp; pfam04986
591020005565	potential frameshift: common BLAST hit: gi|110805722|ref|YP_689242.1| virulence protein
591020005566	Probable transposase; Region: OrfB_IS605; pfam01385
591020005567	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
591020005568	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
591020005569	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
591020005570	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
591020005571	tellurite resistance protein TehB; Provisional; Region: PRK11207
591020005572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020005573	S-adenosylmethionine binding site [chemical binding]; other site
591020005574	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
591020005575	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
591020005576	gating phenylalanine in ion channel; other site
591020005577	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
591020005578	putative trimer interface [polypeptide binding]; other site
591020005579	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
591020005580	putative CoA binding site [chemical binding]; other site
591020005581	putative trimer interface [polypeptide binding]; other site
591020005582	putative CoA binding site [chemical binding]; other site
591020005583	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
591020005584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020005585	Coenzyme A binding pocket [chemical binding]; other site
591020005586	hypothetical protein; Provisional; Region: PRK11415
591020005587	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
591020005588	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
591020005589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
591020005590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
591020005591	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
591020005592	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020005593	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020005594	dimerization interface [polypeptide binding]; other site
591020005595	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
591020005596	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
591020005597	dimer interface [polypeptide binding]; other site
591020005598	ligand binding site [chemical binding]; other site
591020005599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020005600	dimerization interface [polypeptide binding]; other site
591020005601	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
591020005602	dimer interface [polypeptide binding]; other site
591020005603	putative CheW interface [polypeptide binding]; other site
591020005604	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020005605	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020005606	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020005607	putative transposase OrfB; Reviewed; Region: PHA02517
591020005608	HTH-like domain; Region: HTH_21; pfam13276
591020005609	Integrase core domain; Region: rve; pfam00665
591020005610	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020005611	HTH-like domain; Region: HTH_21; pfam13276
591020005612	Integrase core domain; Region: rve; pfam00665
591020005613	Integrase core domain; Region: rve_3; pfam13683
591020005614	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020005615	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020005616	putative transposase OrfB; Reviewed; Region: PHA02517
591020005617	Integrase core domain; Region: rve; pfam00665
591020005618	Integrase core domain; Region: rve_3; pfam13683
591020005619	hypothetical protein; Provisional; Region: PRK10040
591020005620	cytochrome b561; Provisional; Region: PRK11513
591020005621	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
591020005622	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
591020005623	NAD binding site [chemical binding]; other site
591020005624	catalytic residues [active]
591020005625	substrate binding site [chemical binding]; other site
591020005626	Uncharacterized conserved protein [Function unknown]; Region: COG1434
591020005627	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591020005628	putative active site [active]
591020005629	putative transposase OrfB; Reviewed; Region: PHA02517
591020005630	Integrase core domain; Region: rve; pfam00665
591020005631	Integrase core domain; Region: rve_3; pfam13683
591020005632	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
591020005633	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020005634	ATP binding site [chemical binding]; other site
591020005635	putative Mg++ binding site [ion binding]; other site
591020005636	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020005637	nucleotide binding region [chemical binding]; other site
591020005638	ATP-binding site [chemical binding]; other site
591020005639	Helicase associated domain (HA2); Region: HA2; pfam04408
591020005640	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
591020005641	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
591020005642	azoreductase; Reviewed; Region: PRK00170
591020005643	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591020005644	putative transposase OrfB; Reviewed; Region: PHA02517
591020005645	Integrase core domain; Region: rve; pfam00665
591020005646	Integrase core domain; Region: rve_3; pfam13683
591020005647	Putative methyltransferase; Region: Methyltransf_20; pfam12147
591020005648	putative transposase OrfB; Reviewed; Region: PHA02517
591020005649	Integrase core domain; Region: rve; pfam00665
591020005650	Integrase core domain; Region: rve_3; pfam13683
591020005651	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
591020005652	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591020005653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020005654	S-adenosylmethionine binding site [chemical binding]; other site
591020005655	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
591020005656	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
591020005657	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
591020005658	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
591020005659	Protein of unknown function (DUF2773); Region: DUF2773; pfam10971
591020005660	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005661	heat-inducible protein; Provisional; Region: PRK10449
591020005662	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
591020005663	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
591020005664	putative ligand binding site [chemical binding]; other site
591020005665	putative NAD binding site [chemical binding]; other site
591020005666	catalytic site [active]
591020005667	hypothetical protein; Provisional; Region: PRK10695
591020005668	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
591020005669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
591020005670	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020005671	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005672	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
591020005673	Domain of unknown function (DUF333); Region: DUF333; pfam03891
591020005674	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
591020005675	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
591020005676	dimer interface [polypeptide binding]; other site
591020005677	PYR/PP interface [polypeptide binding]; other site
591020005678	TPP binding site [chemical binding]; other site
591020005679	substrate binding site [chemical binding]; other site
591020005680	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
591020005681	Domain of unknown function; Region: EKR; smart00890
591020005682	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591020005683	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
591020005684	TPP-binding site [chemical binding]; other site
591020005685	dimer interface [polypeptide binding]; other site
591020005686	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591020005687	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591020005688	trimer interface [polypeptide binding]; other site
591020005689	eyelet of channel; other site
591020005690	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591020005691	Ligand Binding Site [chemical binding]; other site
591020005692	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
591020005693	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
591020005694	Ligand Binding Site [chemical binding]; other site
591020005695	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
591020005696	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591020005697	ATP binding site [chemical binding]; other site
591020005698	Mg++ binding site [ion binding]; other site
591020005699	motif III; other site
591020005700	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020005701	nucleotide binding region [chemical binding]; other site
591020005702	ATP-binding site [chemical binding]; other site
591020005703	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
591020005704	putative RNA binding site [nucleotide binding]; other site
591020005705	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
591020005706	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
591020005707	Cl binding site [ion binding]; other site
591020005708	oligomer interface [polypeptide binding]; other site
591020005709	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
591020005710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005711	putative substrate translocation pore; other site
591020005712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020005713	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
591020005714	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020005715	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020005716	Putative transposase; Region: Y2_Tnp; pfam04986
591020005717	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
591020005718	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020005719	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
591020005720	Helix-turn-helix domain; Region: HTH_18; pfam12833
591020005721	AbgT putative transporter family; Region: ABG_transport; cl17431
591020005722	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
591020005723	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
591020005724	ligand binding site [chemical binding]; other site
591020005725	flexible hinge region; other site
591020005726	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
591020005727	putative switch regulator; other site
591020005728	non-specific DNA interactions [nucleotide binding]; other site
591020005729	DNA binding site [nucleotide binding]
591020005730	sequence specific DNA binding site [nucleotide binding]; other site
591020005731	putative cAMP binding site [chemical binding]; other site
591020005732	universal stress protein UspE; Provisional; Region: PRK11175
591020005733	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591020005734	Ligand Binding Site [chemical binding]; other site
591020005735	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591020005736	Ligand Binding Site [chemical binding]; other site
591020005737	HTH-like domain; Region: HTH_21; pfam13276
591020005738	Integrase core domain; Region: rve; pfam00665
591020005739	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020005740	Putative transposase; Region: Y2_Tnp; pfam04986
591020005741	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020005742	Transposase; Region: HTH_Tnp_1; pfam01527
591020005743	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
591020005744	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591020005745	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
591020005746	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
591020005747	peptide binding site [polypeptide binding]; other site
591020005748	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020005749	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591020005750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020005751	Transposase; Region: HTH_Tnp_1; pfam01527
591020005752	Integrase core domain; Region: rve; pfam00665
591020005753	Integrase core domain; Region: rve_3; pfam13683
591020005754	Transposase; Region: HTH_Tnp_1; cl17663
591020005755	putative transposase OrfB; Reviewed; Region: PHA02517
591020005756	HTH-like domain; Region: HTH_21; pfam13276
591020005757	Integrase core domain; Region: rve; pfam00665
591020005758	Integrase core domain; Region: rve_3; pfam13683
591020005759	Excisionase-like protein; Region: Exc; pfam07825
591020005760	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
591020005761	hypothetical protein; Provisional; Region: PRK10301
591020005762	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
591020005763	exodeoxyribonuclease X; Provisional; Region: PRK07983
591020005764	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
591020005765	active site
591020005766	catalytic site [active]
591020005767	substrate binding site [chemical binding]; other site
591020005768	protease 2; Provisional; Region: PRK10115
591020005769	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591020005770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
591020005771	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
591020005772	putative metal binding site [ion binding]; other site
591020005773	hypothetical protein; Provisional; Region: PRK13680
591020005774	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
591020005775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591020005776	ATP-grasp domain; Region: ATP-grasp; pfam02222
591020005777	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
591020005778	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
591020005779	active site
591020005780	intersubunit interface [polypeptide binding]; other site
591020005781	catalytic residue [active]
591020005782	phosphogluconate dehydratase; Validated; Region: PRK09054
591020005783	6-phosphogluconate dehydratase; Region: edd; TIGR01196
591020005784	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
591020005785	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
591020005786	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
591020005787	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
591020005788	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591020005789	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591020005790	putative active site [active]
591020005791	pyruvate kinase; Provisional; Region: PRK05826
591020005792	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
591020005793	domain interfaces; other site
591020005794	active site
591020005795	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591020005796	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591020005797	putative acyl-acceptor binding pocket; other site
591020005798	putative peptidase; Provisional; Region: PRK11649
591020005799	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
591020005800	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020005801	Peptidase family M23; Region: Peptidase_M23; pfam01551
591020005802	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
591020005803	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
591020005804	metal binding site [ion binding]; metal-binding site
591020005805	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
591020005806	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
591020005807	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
591020005808	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
591020005809	ABC-ATPase subunit  interface; other site
591020005810	dimer interface [polypeptide binding]; other site
591020005811	putative PBP binding regions; other site
591020005812	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
591020005813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020005814	Walker A motif; other site
591020005815	ATP binding site [chemical binding]; other site
591020005816	Walker B motif; other site
591020005817	arginine finger; other site
591020005818	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
591020005819	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
591020005820	RuvA N terminal domain; Region: RuvA_N; pfam01330
591020005821	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
591020005822	hypothetical protein; Provisional; Region: PRK11470
591020005823	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
591020005824	active site
591020005825	putative DNA-binding cleft [nucleotide binding]; other site
591020005826	dimer interface [polypeptide binding]; other site
591020005827	hypothetical protein; Validated; Region: PRK00110
591020005828	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
591020005829	nudix motif; other site
591020005830	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
591020005831	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
591020005832	dimer interface [polypeptide binding]; other site
591020005833	anticodon binding site; other site
591020005834	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
591020005835	homodimer interface [polypeptide binding]; other site
591020005836	motif 1; other site
591020005837	active site
591020005838	motif 2; other site
591020005839	GAD domain; Region: GAD; pfam02938
591020005840	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
591020005841	motif 3; other site
591020005842	DinI-like family; Region: DinI; pfam06183
591020005843	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020005844	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
591020005845	Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364
591020005846	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
591020005847	Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316
591020005848	Phage-related protein, tail component [Function unknown]; Region: COG4733
591020005849	Putative phage tail protein; Region: Phage-tail_3; pfam13550
591020005850	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
591020005851	Interdomain contacts; other site
591020005852	Cytokine receptor motif; other site
591020005853	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
591020005854	Fibronectin type III protein; Region: DUF3672; pfam12421
591020005855	Phage-related protein, tail component [Function unknown]; Region: COG4723
591020005856	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
591020005857	MPN+ (JAMM) motif; other site
591020005858	Zinc-binding site [ion binding]; other site
591020005859	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
591020005860	NlpC/P60 family; Region: NLPC_P60; cl17555
591020005861	Phage-related protein [Function unknown]; Region: gp18; COG4672
591020005862	Phage-related minor tail protein [Function unknown]; Region: COG5281
591020005863	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
591020005864	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
591020005865	Minor tail protein T; Region: Phage_tail_T; pfam06223
591020005866	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106
591020005867	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
591020005868	Bacterial Ig-like domain 2; Region: BID_2; smart00635
591020005869	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
591020005870	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
591020005871	Phage Head-Tail Attachment; Region: Phage_attach; pfam05354
591020005872	DNA packaging protein FI; Region: Packaging_FI; pfam14000
591020005873	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020005874	Y-family of DNA polymerases; Region: PolY; cl12025
591020005875	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020005876	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
591020005877	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
591020005878	putative transposase OrfB; Reviewed; Region: PHA02517
591020005879	Integrase core domain; Region: rve; pfam00665
591020005880	Integrase core domain; Region: rve_3; pfam13683
591020005881	SPFH domain / Band 7 family; Region: Band_7; pfam01145
591020005882	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
591020005883	ORF6N domain; Region: ORF6N; pfam10543
591020005884	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
591020005885	beta-clamp/clamp loader binding surface; other site
591020005886	Domain of unknown function (DUF4222); Region: DUF4222; pfam13973
591020005887	putative transposase OrfB; Reviewed; Region: PHA02517
591020005888	HTH-like domain; Region: HTH_21; pfam13276
591020005889	Integrase core domain; Region: rve; pfam00665
591020005890	Integrase core domain; Region: rve_3; pfam13683
591020005891	Protein of unknown function DUF72; Region: DUF72; cl00777
591020005892	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
591020005893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020005894	S-adenosylmethionine binding site [chemical binding]; other site
591020005895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020005896	S-adenosylmethionine binding site [chemical binding]; other site
591020005897	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
591020005898	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
591020005899	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
591020005900	molybdopterin cofactor binding site [chemical binding]; other site
591020005901	substrate binding site [chemical binding]; other site
591020005902	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
591020005903	molybdopterin cofactor binding site; other site
591020005904	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
591020005905	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
591020005906	copper homeostasis protein CutC; Provisional; Region: PRK11572
591020005907	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
591020005908	putative metal binding site [ion binding]; other site
591020005909	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
591020005910	arginyl-tRNA synthetase; Region: argS; TIGR00456
591020005911	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
591020005912	active site
591020005913	HIGH motif; other site
591020005914	KMSK motif region; other site
591020005915	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
591020005916	tRNA binding surface [nucleotide binding]; other site
591020005917	anticodon binding site; other site
591020005918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
591020005919	Integrase core domain; Region: rve; pfam00665
591020005920	Integrase core domain; Region: rve_3; pfam13683
591020005921	Transposase; Region: HTH_Tnp_1; cl17663
591020005922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020005923	Flagellar protein FlhE; Region: FlhE; pfam06366
591020005924	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
591020005925	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
591020005926	HD domain; Region: HD; pfam01966
591020005927	Zn2+ binding site [ion binding]; other site
591020005928	Mg2+ binding site [ion binding]; other site
591020005929	putative transposase OrfB; Reviewed; Region: PHA02517
591020005930	HTH-like domain; Region: HTH_21; pfam13276
591020005931	Integrase core domain; Region: rve; pfam00665
591020005932	Integrase core domain; Region: rve_3; pfam13683
591020005933	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
591020005934	metal binding triad [ion binding]; metal-binding site
591020005935	putative transposase OrfB; Reviewed; Region: PHA02517
591020005936	Integrase core domain; Region: rve; pfam00665
591020005937	Integrase core domain; Region: rve_3; pfam13683
591020005938	chemotaxis regulator CheZ; Provisional; Region: PRK11166
591020005939	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
591020005940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020005941	active site
591020005942	phosphorylation site [posttranslational modification]
591020005943	intermolecular recognition site; other site
591020005944	dimerization interface [polypeptide binding]; other site
591020005945	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
591020005946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020005947	active site
591020005948	phosphorylation site [posttranslational modification]
591020005949	intermolecular recognition site; other site
591020005950	dimerization interface [polypeptide binding]; other site
591020005951	CheB methylesterase; Region: CheB_methylest; pfam01339
591020005952	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
591020005953	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
591020005954	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020005955	S-adenosylmethionine binding site [chemical binding]; other site
591020005956	methyl-accepting protein IV; Provisional; Region: PRK09793
591020005957	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
591020005958	dimer interface [polypeptide binding]; other site
591020005959	ligand binding site [chemical binding]; other site
591020005960	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020005961	dimerization interface [polypeptide binding]; other site
591020005962	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
591020005963	dimer interface [polypeptide binding]; other site
591020005964	putative CheW interface [polypeptide binding]; other site
591020005965	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
591020005966	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
591020005967	dimer interface [polypeptide binding]; other site
591020005968	ligand binding site [chemical binding]; other site
591020005969	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020005970	dimerization interface [polypeptide binding]; other site
591020005971	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
591020005972	dimer interface [polypeptide binding]; other site
591020005973	putative CheW interface [polypeptide binding]; other site
591020005974	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
591020005975	putative CheA interaction surface; other site
591020005976	chemotaxis protein CheA; Provisional; Region: PRK10547
591020005977	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591020005978	putative binding surface; other site
591020005979	active site
591020005980	CheY binding; Region: CheY-binding; pfam09078
591020005981	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
591020005982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020005983	ATP binding site [chemical binding]; other site
591020005984	Mg2+ binding site [ion binding]; other site
591020005985	G-X-G motif; other site
591020005986	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
591020005987	flagellar motor protein MotB; Validated; Region: motB; PRK09041
591020005988	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
591020005989	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591020005990	ligand binding site [chemical binding]; other site
591020005991	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
591020005992	flagellar motor protein MotA; Validated; Region: PRK09110
591020005993	transcriptional activator FlhC; Provisional; Region: PRK12722
591020005994	Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012
591020005995	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020005996	trehalose-6-phosphate synthase; Provisional; Region: PRK10117
591020005997	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
591020005998	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
591020005999	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020006000	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020006001	TM-ABC transporter signature motif; other site
591020006002	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
591020006003	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591020006004	Walker A/P-loop; other site
591020006005	ATP binding site [chemical binding]; other site
591020006006	Q-loop/lid; other site
591020006007	ABC transporter signature motif; other site
591020006008	Walker B; other site
591020006009	D-loop; other site
591020006010	H-loop/switch region; other site
591020006011	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591020006012	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
591020006013	Ferritin-like domain; Region: Ferritin; pfam00210
591020006014	ferroxidase diiron center [ion binding]; other site
591020006015	YecR-like lipoprotein; Region: YecR; pfam13992
591020006016	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
591020006017	Ferritin-like domain; Region: Ferritin; pfam00210
591020006018	ferroxidase diiron center [ion binding]; other site
591020006019	probable metal-binding protein; Region: matur_matur; TIGR03853
591020006020	tyrosine transporter TyrP; Provisional; Region: PRK15132
591020006021	aromatic amino acid transport protein; Region: araaP; TIGR00837
591020006022	hypothetical protein; Provisional; Region: PRK10396
591020006023	yecA family protein; Region: ygfB_yecA; TIGR02292
591020006024	SEC-C motif; Region: SEC-C; pfam02810
591020006025	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
591020006026	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
591020006027	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
591020006028	GIY-YIG motif/motif A; other site
591020006029	active site
591020006030	catalytic site [active]
591020006031	putative DNA binding site [nucleotide binding]; other site
591020006032	metal binding site [ion binding]; metal-binding site
591020006033	UvrB/uvrC motif; Region: UVR; pfam02151
591020006034	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
591020006035	Helix-hairpin-helix motif; Region: HHH; pfam00633
591020006036	response regulator; Provisional; Region: PRK09483
591020006037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020006038	active site
591020006039	phosphorylation site [posttranslational modification]
591020006040	intermolecular recognition site; other site
591020006041	dimerization interface [polypeptide binding]; other site
591020006042	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020006043	DNA binding residues [nucleotide binding]
591020006044	dimerization interface [polypeptide binding]; other site
591020006045	hypothetical protein; Provisional; Region: PRK10613
591020006046	Autoinducer binding domain; Region: Autoind_bind; pfam03472
591020006047	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020006048	DNA binding residues [nucleotide binding]
591020006049	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
591020006050	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591020006051	Walker A/P-loop; other site
591020006052	ATP binding site [chemical binding]; other site
591020006053	Q-loop/lid; other site
591020006054	ABC transporter signature motif; other site
591020006055	Walker B; other site
591020006056	D-loop; other site
591020006057	H-loop/switch region; other site
591020006058	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591020006059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020006060	dimer interface [polypeptide binding]; other site
591020006061	conserved gate region; other site
591020006062	putative PBP binding loops; other site
591020006063	ABC-ATPase subunit interface; other site
591020006064	D-cysteine desulfhydrase; Validated; Region: PRK03910
591020006065	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
591020006066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020006067	catalytic residue [active]
591020006068	cystine transporter subunit; Provisional; Region: PRK11260
591020006069	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020006070	substrate binding pocket [chemical binding]; other site
591020006071	membrane-bound complex binding site; other site
591020006072	hinge residues; other site
591020006073	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
591020006074	flagellin; Validated; Region: PRK08026
591020006075	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
591020006076	Flagellin protein; Region: FliC; pfam12445
591020006077	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
591020006078	flagellar capping protein; Reviewed; Region: fliD; PRK08032
591020006079	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
591020006080	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
591020006081	Flagellar protein FliS; Region: FliS; cl00654
591020006082	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
591020006083	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
591020006084	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
591020006085	active site
591020006086	Na/Ca binding site [ion binding]; other site
591020006087	catalytic site [active]
591020006088	lipoprotein; Provisional; Region: PRK10397
591020006089	putative inner membrane protein; Provisional; Region: PRK11099
591020006090	Probable transposase; Region: OrfB_IS605; pfam01385
591020006091	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
591020006092	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
591020006093	Transposase IS200 like; Region: Y1_Tnp; cl00848
591020006094	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591020006095	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591020006096	trimer interface [polypeptide binding]; other site
591020006097	eyelet of channel; other site
591020006098	transcriptional regulator HilD; Provisional; Region: PRK15185
591020006099	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
591020006100	substrate binding site [chemical binding]; other site
591020006101	multidrug efflux protein; Reviewed; Region: emrE; PRK09541
591020006102	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
591020006103	flagellar motor switch protein FliG; Region: fliG; TIGR00207
591020006104	FliG C-terminal domain; Region: FliG_C; pfam01706
591020006105	flagellar assembly protein H; Validated; Region: fliH; PRK05687
591020006106	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
591020006107	Flagellar assembly protein FliH; Region: FliH; pfam02108
591020006108	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
591020006109	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
591020006110	Walker A motif/ATP binding site; other site
591020006111	Walker B motif; other site
591020006112	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
591020006113	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
591020006114	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
591020006115	flagellar hook-length control protein; Provisional; Region: PRK10118
591020006116	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
591020006117	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
591020006118	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
591020006119	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
591020006120	flagellar motor switch protein; Validated; Region: fliN; PRK05698
591020006121	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
591020006122	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
591020006123	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
591020006124	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
591020006125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020006126	DNA binding residues [nucleotide binding]
591020006127	dimerization interface [polypeptide binding]; other site
591020006128	hypothetical protein; Provisional; Region: PRK10708
591020006129	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
591020006130	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
591020006131	hypothetical protein; Provisional; Region: PRK10062
591020006132	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
591020006133	EamA-like transporter family; Region: EamA; pfam00892
591020006134	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
591020006135	additional DNA contacts [nucleotide binding]; other site
591020006136	mismatch recognition site; other site
591020006137	active site
591020006138	zinc binding site [ion binding]; other site
591020006139	DNA intercalation site [nucleotide binding]; other site
591020006140	DNA cytosine methylase; Provisional; Region: PRK10458
591020006141	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
591020006142	cofactor binding site; other site
591020006143	DNA binding site [nucleotide binding]
591020006144	substrate interaction site [chemical binding]; other site
591020006145	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
591020006146	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591020006147	Zn2+ binding site [ion binding]; other site
591020006148	Mg2+ binding site [ion binding]; other site
591020006149	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
591020006150	putative transposase OrfB; Reviewed; Region: PHA02517
591020006151	HTH-like domain; Region: HTH_21; pfam13276
591020006152	Integrase core domain; Region: rve; pfam00665
591020006153	Integrase core domain; Region: rve_2; pfam13333
591020006154	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020006155	Transposase; Region: HTH_Tnp_1; pfam01527
591020006156	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591020006157	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591020006158	eyelet of channel; other site
591020006159	trimer interface [polypeptide binding]; other site
591020006160	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020006161	HTH-like domain; Region: HTH_21; pfam13276
591020006162	Integrase core domain; Region: rve; pfam00665
591020006163	Integrase core domain; Region: rve_3; pfam13683
591020006164	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
591020006165	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006166	chaperone protein HchA; Provisional; Region: PRK04155
591020006167	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
591020006168	dimer interface [polypeptide binding]; other site
591020006169	metal binding site [ion binding]; metal-binding site
591020006170	potential oxyanion hole; other site
591020006171	potential catalytic triad [active]
591020006172	conserved cys residue [active]
591020006173	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
591020006174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020006175	dimer interface [polypeptide binding]; other site
591020006176	phosphorylation site [posttranslational modification]
591020006177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020006178	ATP binding site [chemical binding]; other site
591020006179	Mg2+ binding site [ion binding]; other site
591020006180	G-X-G motif; other site
591020006181	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
591020006182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020006183	active site
591020006184	phosphorylation site [posttranslational modification]
591020006185	intermolecular recognition site; other site
591020006186	dimerization interface [polypeptide binding]; other site
591020006187	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020006188	DNA binding site [nucleotide binding]
591020006189	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
591020006190	active site
591020006191	homotetramer interface [polypeptide binding]; other site
591020006192	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
591020006193	zinc/cadmium-binding protein; Provisional; Region: PRK10306
591020006194	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591020006195	Methyltransferase domain; Region: Methyltransf_31; pfam13847
591020006196	Methyltransferase domain; Region: Methyltransf_12; pfam08242
591020006197	S-adenosylmethionine binding site [chemical binding]; other site
591020006198	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020006199	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
591020006200	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
591020006201	putative transposase OrfB; Reviewed; Region: PHA02517
591020006202	Integrase core domain; Region: rve; pfam00665
591020006203	Integrase core domain; Region: rve_3; pfam13683
591020006204	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006205	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
591020006206	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
591020006207	Phage tail tube protein; Region: Tail_tube; pfam10618
591020006208	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
591020006209	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
591020006210	putative transposase OrfB; Reviewed; Region: PHA02517
591020006211	Integrase core domain; Region: rve; pfam00665
591020006212	Integrase core domain; Region: rve_3; pfam13683
591020006213	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020006214	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020006215	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020006216	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020006217	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020006218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020006219	Homeodomain-like domain; Region: HTH_23; pfam13384
591020006220	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020006221	Transposase; Region: HTH_Tnp_1; pfam01527
591020006222	Lysis protein S; Region: Lysis_S; pfam04971
591020006223	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
591020006224	Protein of unknown function (DUF968); Region: DUF968; pfam06147
591020006225	Hok/gef family; Region: HOK_GEF; pfam01848
591020006226	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
591020006227	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020006228	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020006229	active site
591020006230	DNA binding site [nucleotide binding]
591020006231	Int/Topo IB signature motif; other site
591020006232	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
591020006233	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591020006234	active site
591020006235	Int/Topo IB signature motif; other site
591020006236	putative transposase OrfB; Reviewed; Region: PHA02517
591020006237	HTH-like domain; Region: HTH_21; pfam13276
591020006238	Integrase core domain; Region: rve; pfam00665
591020006239	Integrase core domain; Region: rve_3; pfam13683
591020006240	AMP nucleosidase; Provisional; Region: PRK08292
591020006241	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
591020006242	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
591020006243	hypothetical protein; Provisional; Region: PRK12378
591020006244	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
591020006245	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020006246	The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444
591020006247	putative substrate binding site [chemical binding]; other site
591020006248	dimerization interface [polypeptide binding]; other site
591020006249	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
591020006250	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020006251	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
591020006252	putative dimerization interface [polypeptide binding]; other site
591020006253	L,D-transpeptidase; Provisional; Region: PRK10190
591020006254	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
591020006255	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
591020006256	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
591020006257	putative dimer interface [polypeptide binding]; other site
591020006258	active site pocket [active]
591020006259	putative cataytic base [active]
591020006260	cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317
591020006261	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
591020006262	GTP binding site [chemical binding]; other site
591020006263	Walker B motif; other site
591020006264	homotrimer interface [polypeptide binding]; other site
591020006265	putative transposase OrfB; Reviewed; Region: PHA02517
591020006266	HTH-like domain; Region: HTH_21; pfam13276
591020006267	Integrase core domain; Region: rve; pfam00665
591020006268	Integrase core domain; Region: rve_3; pfam13683
591020006269	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020006270	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020006271	HTH-like domain; Region: HTH_21; pfam13276
591020006272	Integrase core domain; Region: rve; pfam00665
591020006273	Integrase core domain; Region: rve_3; pfam13683
591020006274	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020006275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020006276	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020006277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020006278	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020006279	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020006280	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020006281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020006282	Homeodomain-like domain; Region: HTH_23; pfam13384
591020006283	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020006284	Transposase; Region: HTH_Tnp_1; pfam01527
591020006285	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020006286	exonuclease I; Provisional; Region: sbcB; PRK11779
591020006287	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
591020006288	active site
591020006289	catalytic site [active]
591020006290	substrate binding site [chemical binding]; other site
591020006291	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
591020006292	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
591020006293	CPxP  motif; other site
591020006294	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
591020006295	Sulphur transport; Region: Sulf_transp; pfam04143
591020006296	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
591020006297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020006298	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
591020006299	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020006300	dimerization interface [polypeptide binding]; other site
591020006301	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591020006302	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
591020006303	putative NAD(P) binding site [chemical binding]; other site
591020006304	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
591020006305	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006306	antitoxin YefM; Provisional; Region: PRK11409
591020006307	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
591020006308	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
591020006309	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
591020006310	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
591020006311	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
591020006312	NAD binding site [chemical binding]; other site
591020006313	dimerization interface [polypeptide binding]; other site
591020006314	product binding site; other site
591020006315	substrate binding site [chemical binding]; other site
591020006316	zinc binding site [ion binding]; other site
591020006317	catalytic residues [active]
591020006318	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
591020006319	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591020006320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020006321	homodimer interface [polypeptide binding]; other site
591020006322	catalytic residue [active]
591020006323	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
591020006324	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020006325	active site
591020006326	motif I; other site
591020006327	motif II; other site
591020006328	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
591020006329	putative active site pocket [active]
591020006330	4-fold oligomerization interface [polypeptide binding]; other site
591020006331	metal binding residues [ion binding]; metal-binding site
591020006332	3-fold/trimer interface [polypeptide binding]; other site
591020006333	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
591020006334	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
591020006335	putative active site [active]
591020006336	oxyanion strand; other site
591020006337	catalytic triad [active]
591020006338	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
591020006339	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
591020006340	catalytic residues [active]
591020006341	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
591020006342	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
591020006343	substrate binding site [chemical binding]; other site
591020006344	glutamase interaction surface [polypeptide binding]; other site
591020006345	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
591020006346	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
591020006347	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
591020006348	metal binding site [ion binding]; metal-binding site
591020006349	chain length determinant protein WzzB; Provisional; Region: PRK15471
591020006350	Chain length determinant protein; Region: Wzz; pfam02706
591020006351	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591020006352	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
591020006353	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
591020006354	potential frameshift: common BLAST hit: gi|313200833|ref|YP_004039491.1| dolichyl-phosphate-mannose-protein mannosyltransferase protein
591020006355	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
591020006356	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
591020006357	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
591020006358	Ligand binding site; other site
591020006359	Putative Catalytic site; other site
591020006360	DXD motif; other site
591020006361	Predicted membrane protein [Function unknown]; Region: COG2246
591020006362	GtrA-like protein; Region: GtrA; pfam04138
591020006363	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
591020006364	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
591020006365	Probable Catalytic site; other site
591020006366	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
591020006367	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
591020006368	Ligand binding site; other site
591020006369	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
591020006370	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
591020006371	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
591020006372	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
591020006373	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
591020006374	substrate binding site; other site
591020006375	tetramer interface; other site
591020006376	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
591020006377	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
591020006378	NADP binding site [chemical binding]; other site
591020006379	active site
591020006380	putative substrate binding site [chemical binding]; other site
591020006381	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
591020006382	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
591020006383	NAD binding site [chemical binding]; other site
591020006384	substrate binding site [chemical binding]; other site
591020006385	homodimer interface [polypeptide binding]; other site
591020006386	active site
591020006387	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
591020006388	active site
591020006389	tetramer interface; other site
591020006390	putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123
591020006391	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
591020006392	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
591020006393	putative ADP-binding pocket [chemical binding]; other site
591020006394	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
591020006395	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
591020006396	colanic acid exporter; Provisional; Region: PRK10459
591020006397	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
591020006398	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
591020006399	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
591020006400	phosphomannomutase CpsG; Provisional; Region: PRK15414
591020006401	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
591020006402	active site
591020006403	substrate binding site [chemical binding]; other site
591020006404	metal binding site [ion binding]; metal-binding site
591020006405	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
591020006406	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
591020006407	Substrate binding site; other site
591020006408	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
591020006409	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
591020006410	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
591020006411	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
591020006412	dimer interface [polypeptide binding]; other site
591020006413	active site
591020006414	GDP-Mannose binding site [chemical binding]; other site
591020006415	modified nudix motif
591020006416	metal binding site [ion binding]; metal-binding site
591020006417	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
591020006418	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
591020006419	NADP binding site [chemical binding]; other site
591020006420	active site
591020006421	putative substrate binding site [chemical binding]; other site
591020006422	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
591020006423	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
591020006424	NADP-binding site; other site
591020006425	homotetramer interface [polypeptide binding]; other site
591020006426	substrate binding site [chemical binding]; other site
591020006427	homodimer interface [polypeptide binding]; other site
591020006428	active site
591020006429	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
591020006430	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
591020006431	putative trimer interface [polypeptide binding]; other site
591020006432	putative active site [active]
591020006433	putative substrate binding site [chemical binding]; other site
591020006434	putative CoA binding site [chemical binding]; other site
591020006435	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
591020006436	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006437	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075
591020006438	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
591020006439	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591020006440	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591020006441	putative acyl transferase; Provisional; Region: PRK10191
591020006442	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
591020006443	trimer interface [polypeptide binding]; other site
591020006444	active site
591020006445	substrate binding site [chemical binding]; other site
591020006446	CoA binding site [chemical binding]; other site
591020006447	tyrosine kinase; Provisional; Region: PRK11519
591020006448	Chain length determinant protein; Region: Wzz; pfam02706
591020006449	Chain length determinant protein; Region: Wzz; cl15801
591020006450	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
591020006451	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591020006452	Low molecular weight phosphatase family; Region: LMWPc; cd00115
591020006453	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
591020006454	active site
591020006455	polysaccharide export protein Wza; Provisional; Region: PRK15078
591020006456	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
591020006457	SLBB domain; Region: SLBB; pfam10531
591020006458	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
591020006459	FOG: CBS domain [General function prediction only]; Region: COG0517
591020006460	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591020006461	Transporter associated domain; Region: CorC_HlyC; smart01091
591020006462	putative assembly protein; Provisional; Region: PRK10833
591020006463	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
591020006464	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
591020006465	trimer interface [polypeptide binding]; other site
591020006466	active site
591020006467	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
591020006468	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
591020006469	ATP-binding site [chemical binding]; other site
591020006470	Sugar specificity; other site
591020006471	Pyrimidine base specificity; other site
591020006472	MASE1; Region: MASE1; cl17823
591020006473	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020006474	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591020006475	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
591020006476	putative transporter; Provisional; Region: PRK10504
591020006477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020006478	putative substrate translocation pore; other site
591020006479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020006480	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
591020006481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020006482	active site
591020006483	phosphorylation site [posttranslational modification]
591020006484	intermolecular recognition site; other site
591020006485	dimerization interface [polypeptide binding]; other site
591020006486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020006487	DNA binding site [nucleotide binding]
591020006488	Uncharacterized conserved protein [Function unknown]; Region: COG3422
591020006489	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
591020006490	putative protease; Provisional; Region: PRK15452
591020006491	Peptidase family U32; Region: Peptidase_U32; pfam01136
591020006492	lipid kinase; Reviewed; Region: PRK13054
591020006493	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
591020006494	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591020006495	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591020006496	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020006497	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
591020006498	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
591020006499	putative NAD(P) binding site [chemical binding]; other site
591020006500	catalytic Zn binding site [ion binding]; other site
591020006501	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006502	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
591020006503	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
591020006504	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
591020006505	active site
591020006506	P-loop; other site
591020006507	phosphorylation site [posttranslational modification]
591020006508	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020006509	active site
591020006510	phosphorylation site [posttranslational modification]
591020006511	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
591020006512	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
591020006513	intersubunit interface [polypeptide binding]; other site
591020006514	active site
591020006515	zinc binding site [ion binding]; other site
591020006516	Na+ binding site [ion binding]; other site
591020006517	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
591020006518	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
591020006519	putative active site; other site
591020006520	catalytic residue [active]
591020006521	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
591020006522	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020006523	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
591020006524	substrate binding site [chemical binding]; other site
591020006525	ATP binding site [chemical binding]; other site
591020006526	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591020006527	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020006528	DNA-binding site [nucleotide binding]; DNA binding site
591020006529	UTRA domain; Region: UTRA; pfam07702
591020006530	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
591020006531	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
591020006532	active site
591020006533	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
591020006534	dimer interface [polypeptide binding]; other site
591020006535	substrate binding site [chemical binding]; other site
591020006536	ATP binding site [chemical binding]; other site
591020006537	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
591020006538	substrate binding site [chemical binding]; other site
591020006539	multimerization interface [polypeptide binding]; other site
591020006540	ATP binding site [chemical binding]; other site
591020006541	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
591020006542	putative metal binding site [ion binding]; other site
591020006543	putative homodimer interface [polypeptide binding]; other site
591020006544	putative homotetramer interface [polypeptide binding]; other site
591020006545	putative homodimer-homodimer interface [polypeptide binding]; other site
591020006546	putative allosteric switch controlling residues; other site
591020006547	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
591020006548	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
591020006549	PapC N-terminal domain; Region: PapC_N; pfam13954
591020006550	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020006551	PapC C-terminal domain; Region: PapC_C; pfam13953
591020006552	putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253
591020006553	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591020006554	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591020006555	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591020006556	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006557	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
591020006558	antiporter inner membrane protein; Provisional; Region: PRK11670
591020006559	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
591020006560	Walker A motif; other site
591020006561	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
591020006562	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
591020006563	active site
591020006564	HIGH motif; other site
591020006565	KMSKS motif; other site
591020006566	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
591020006567	tRNA binding surface [nucleotide binding]; other site
591020006568	anticodon binding site; other site
591020006569	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
591020006570	dimer interface [polypeptide binding]; other site
591020006571	putative tRNA-binding site [nucleotide binding]; other site
591020006572	putative transposase OrfB; Reviewed; Region: PHA02517
591020006573	Integrase core domain; Region: rve; pfam00665
591020006574	Integrase core domain; Region: rve_3; pfam13683
591020006575	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006576	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
591020006577	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
591020006578	MoxR-like ATPases [General function prediction only]; Region: COG0714
591020006579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020006580	Walker A motif; other site
591020006581	ATP binding site [chemical binding]; other site
591020006582	Walker B motif; other site
591020006583	arginine finger; other site
591020006584	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
591020006585	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
591020006586	metal ion-dependent adhesion site (MIDAS); other site
591020006587	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
591020006589	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
591020006590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020006591	active site
591020006592	phosphorylation site [posttranslational modification]
591020006593	intermolecular recognition site; other site
591020006594	dimerization interface [polypeptide binding]; other site
591020006595	LytTr DNA-binding domain; Region: LytTR; pfam04397
591020006596	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
591020006597	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
591020006598	GAF domain; Region: GAF; pfam01590
591020006599	Histidine kinase; Region: His_kinase; pfam06580
591020006600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020006601	ATP binding site [chemical binding]; other site
591020006602	Mg2+ binding site [ion binding]; other site
591020006603	G-X-G motif; other site
591020006604	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020006605	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020006606	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
591020006607	DNA binding residues [nucleotide binding]
591020006608	DinI-like family; Region: DinI; pfam06183
591020006609	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591020006610	Methyltransferase domain; Region: Methyltransf_12; pfam08242
591020006611	S-adenosylmethionine binding site [chemical binding]; other site
591020006612	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020006613	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
591020006614	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
591020006615	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591020006616	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006617	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
591020006618	Transposase; Region: HTH_Tnp_1; cl17663
591020006619	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020006620	HTH-like domain; Region: HTH_21; pfam13276
591020006621	Integrase core domain; Region: rve; pfam00665
591020006622	Integrase core domain; Region: rve_3; pfam13683
591020006623	transcriptional regulator MirA; Provisional; Region: PRK15043
591020006624	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
591020006625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020006626	dimer interface [polypeptide binding]; other site
591020006627	conserved gate region; other site
591020006628	putative PBP binding loops; other site
591020006629	ABC-ATPase subunit interface; other site
591020006630	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
591020006631	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
591020006632	Walker A/P-loop; other site
591020006633	ATP binding site [chemical binding]; other site
591020006634	Q-loop/lid; other site
591020006635	ABC transporter signature motif; other site
591020006636	Walker B; other site
591020006637	D-loop; other site
591020006638	H-loop/switch region; other site
591020006639	CBS domain; Region: CBS; pfam00571
591020006640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020006641	dimer interface [polypeptide binding]; other site
591020006642	conserved gate region; other site
591020006643	ABC-ATPase subunit interface; other site
591020006644	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
591020006645	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
591020006646	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
591020006647	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
591020006648	D-lactate dehydrogenase; Provisional; Region: PRK11183
591020006649	FAD binding domain; Region: FAD_binding_4; pfam01565
591020006650	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
591020006651	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
591020006652	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
591020006653	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
591020006654	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591020006655	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
591020006656	Outer membrane efflux protein; Region: OEP; pfam02321
591020006657	Outer membrane efflux protein; Region: OEP; pfam02321
591020006658	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
591020006659	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
591020006660	FMN binding site [chemical binding]; other site
591020006661	active site
591020006662	catalytic residues [active]
591020006663	substrate binding site [chemical binding]; other site
591020006664	hypothetical protein; Provisional; Region: PRK01821
591020006665	hypothetical protein; Provisional; Region: PRK10711
591020006666	cytidine deaminase; Provisional; Region: PRK09027
591020006667	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
591020006668	active site
591020006669	catalytic motif [active]
591020006670	Zn binding site [ion binding]; other site
591020006671	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
591020006672	active site
591020006673	catalytic motif [active]
591020006674	Zn binding site [ion binding]; other site
591020006675	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591020006676	putative active site [active]
591020006677	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
591020006678	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
591020006679	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020006680	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020006681	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020006682	TM-ABC transporter signature motif; other site
591020006683	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591020006684	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
591020006685	Walker A/P-loop; other site
591020006686	ATP binding site [chemical binding]; other site
591020006687	Q-loop/lid; other site
591020006688	ABC transporter signature motif; other site
591020006689	Walker B; other site
591020006690	D-loop; other site
591020006691	H-loop/switch region; other site
591020006692	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591020006693	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
591020006694	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
591020006695	ligand binding site [chemical binding]; other site
591020006696	calcium binding site [ion binding]; other site
591020006697	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
591020006698	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020006699	DNA binding site [nucleotide binding]
591020006700	domain linker motif; other site
591020006701	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
591020006702	dimerization interface (closed form) [polypeptide binding]; other site
591020006703	ligand binding site [chemical binding]; other site
591020006704	Predicted membrane protein [Function unknown]; Region: COG2311
591020006705	hypothetical protein; Provisional; Region: PRK10835
591020006706	lysine transporter; Provisional; Region: PRK10836
591020006707	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
591020006708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020006709	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
591020006710	putative dimerization interface [polypeptide binding]; other site
591020006711	conserved hypothetical integral membrane protein; Region: TIGR00698
591020006712	endonuclease IV; Provisional; Region: PRK01060
591020006713	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
591020006714	AP (apurinic/apyrimidinic) site pocket; other site
591020006715	DNA interaction; other site
591020006716	Metal-binding active site; metal-binding site
591020006717	putative kinase; Provisional; Region: PRK09954
591020006718	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
591020006719	substrate binding site [chemical binding]; other site
591020006720	ATP binding site [chemical binding]; other site
591020006721	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
591020006722	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
591020006723	Nucleoside recognition; Region: Gate; pfam07670
591020006724	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
591020006725	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
591020006726	active site
591020006727	tetramer interface [polypeptide binding]; other site
591020006728	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
591020006729	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
591020006730	ligand binding site [chemical binding]; other site
591020006731	flexible hinge region; other site
591020006732	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
591020006733	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
591020006734	Nucleoside recognition; Region: Gate; pfam07670
591020006735	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
591020006736	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
591020006737	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
591020006738	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020006739	substrate binding site [chemical binding]; other site
591020006740	ATP binding site [chemical binding]; other site
591020006741	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
591020006742	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
591020006743	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591020006744	active site
591020006745	P-loop; other site
591020006746	phosphorylation site [posttranslational modification]
591020006747	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
591020006748	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
591020006749	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
591020006750	putative substrate binding site [chemical binding]; other site
591020006751	putative ATP binding site [chemical binding]; other site
591020006752	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
591020006753	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020006754	active site
591020006755	phosphorylation site [posttranslational modification]
591020006756	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591020006757	dimerization domain swap beta strand [polypeptide binding]; other site
591020006758	regulatory protein interface [polypeptide binding]; other site
591020006759	active site
591020006760	regulatory phosphorylation site [posttranslational modification]; other site
591020006761	sugar efflux transporter B; Provisional; Region: PRK15011
591020006762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020006763	putative substrate translocation pore; other site
591020006764	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020006765	Flagellin N-methylase; Region: FliB; pfam03692
591020006766	elongation factor P; Provisional; Region: PRK04542
591020006767	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
591020006768	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
591020006769	RNA binding site [nucleotide binding]; other site
591020006770	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
591020006771	RNA binding site [nucleotide binding]; other site
591020006772	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
591020006773	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591020006774	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591020006775	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
591020006776	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
591020006777	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
591020006778	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
591020006779	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
591020006780	active site
591020006781	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
591020006782	NlpC/P60 family; Region: NLPC_P60; pfam00877
591020006783	phage resistance protein; Provisional; Region: PRK10551
591020006784	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
591020006785	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020006786	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
591020006787	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
591020006788	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
591020006789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020006790	dimer interface [polypeptide binding]; other site
591020006791	conserved gate region; other site
591020006792	putative PBP binding loops; other site
591020006793	ABC-ATPase subunit interface; other site
591020006794	microcin C ABC transporter permease; Provisional; Region: PRK15021
591020006795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020006796	dimer interface [polypeptide binding]; other site
591020006797	conserved gate region; other site
591020006798	ABC-ATPase subunit interface; other site
591020006799	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
591020006800	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020006801	Walker A/P-loop; other site
591020006802	ATP binding site [chemical binding]; other site
591020006803	Q-loop/lid; other site
591020006804	ABC transporter signature motif; other site
591020006805	Walker B; other site
591020006806	D-loop; other site
591020006807	H-loop/switch region; other site
591020006808	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591020006809	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020006810	Walker A/P-loop; other site
591020006811	ATP binding site [chemical binding]; other site
591020006812	Q-loop/lid; other site
591020006813	ABC transporter signature motif; other site
591020006814	Walker B; other site
591020006815	D-loop; other site
591020006816	H-loop/switch region; other site
591020006817	hypothetical protein; Provisional; Region: PRK11835
591020006818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020006819	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
591020006820	putative substrate translocation pore; other site
591020006821	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
591020006822	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020006823	RNA binding surface [nucleotide binding]; other site
591020006824	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
591020006825	active site
591020006826	uracil binding [chemical binding]; other site
591020006827	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
591020006828	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020006829	ATP binding site [chemical binding]; other site
591020006830	putative Mg++ binding site [ion binding]; other site
591020006831	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020006832	nucleotide binding region [chemical binding]; other site
591020006833	ATP-binding site [chemical binding]; other site
591020006834	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
591020006835	Nucleoid-associated protein [General function prediction only]; Region: COG3081
591020006836	nucleoid-associated protein NdpA; Validated; Region: PRK00378
591020006837	hypothetical protein; Provisional; Region: PRK13689
591020006838	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
591020006839	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
591020006840	Sulfatase; Region: Sulfatase; pfam00884
591020006841	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
591020006842	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
591020006843	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020006844	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591020006845	transcriptional regulator NarP; Provisional; Region: PRK10403
591020006846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020006847	active site
591020006848	phosphorylation site [posttranslational modification]
591020006849	intermolecular recognition site; other site
591020006850	dimerization interface [polypeptide binding]; other site
591020006851	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020006852	DNA binding residues [nucleotide binding]
591020006853	dimerization interface [polypeptide binding]; other site
591020006854	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
591020006855	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
591020006856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591020006857	binding surface
591020006858	TPR motif; other site
591020006859	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
591020006860	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
591020006861	catalytic residues [active]
591020006862	central insert; other site
591020006863	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
591020006864	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
591020006865	heme exporter protein CcmC; Region: ccmC; TIGR01191
591020006866	heme exporter protein CcmB; Region: ccmB; TIGR01190
591020006867	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
591020006868	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
591020006869	Walker A/P-loop; other site
591020006870	ATP binding site [chemical binding]; other site
591020006871	Q-loop/lid; other site
591020006872	ABC transporter signature motif; other site
591020006873	Walker B; other site
591020006874	D-loop; other site
591020006875	H-loop/switch region; other site
591020006876	cytochrome c-type protein NapC; Provisional; Region: PRK10617
591020006877	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
591020006878	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
591020006879	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
591020006880	4Fe-4S binding domain; Region: Fer4_5; pfam12801
591020006881	4Fe-4S binding domain; Region: Fer4; cl02805
591020006882	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
591020006883	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
591020006884	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
591020006885	[4Fe-4S] binding site [ion binding]; other site
591020006886	molybdopterin cofactor binding site; other site
591020006887	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
591020006888	molybdopterin cofactor binding site; other site
591020006889	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
591020006890	ferredoxin-type protein; Provisional; Region: PRK10194
591020006891	tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750
591020006892	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
591020006893	secondary substrate binding site; other site
591020006894	primary substrate binding site; other site
591020006895	inhibition loop; other site
591020006896	dimerization interface [polypeptide binding]; other site
591020006897	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
591020006898	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
591020006899	Walker A/P-loop; other site
591020006900	ATP binding site [chemical binding]; other site
591020006901	Q-loop/lid; other site
591020006902	ABC transporter signature motif; other site
591020006903	Walker B; other site
591020006904	D-loop; other site
591020006905	H-loop/switch region; other site
591020006906	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
591020006907	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
591020006908	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
591020006909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020006910	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020006911	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
591020006912	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
591020006913	DNA binding site [nucleotide binding]
591020006914	active site
591020006915	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
591020006916	ApbE family; Region: ApbE; pfam02424
591020006917	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
591020006918	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
591020006919	trimer interface [polypeptide binding]; other site
591020006920	eyelet of channel; other site
591020006921	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
591020006922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020006923	ATP binding site [chemical binding]; other site
591020006924	G-X-G motif; other site
591020006925	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591020006926	putative binding surface; other site
591020006927	active site
591020006928	transcriptional regulator RcsB; Provisional; Region: PRK10840
591020006929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020006930	active site
591020006931	phosphorylation site [posttranslational modification]
591020006932	intermolecular recognition site; other site
591020006933	dimerization interface [polypeptide binding]; other site
591020006934	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020006935	DNA binding residues [nucleotide binding]
591020006936	dimerization interface [polypeptide binding]; other site
591020006937	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
591020006938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020006939	dimer interface [polypeptide binding]; other site
591020006940	phosphorylation site [posttranslational modification]
591020006941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020006942	ATP binding site [chemical binding]; other site
591020006943	Mg2+ binding site [ion binding]; other site
591020006944	G-X-G motif; other site
591020006945	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
591020006946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020006947	active site
591020006948	phosphorylation site [posttranslational modification]
591020006949	intermolecular recognition site; other site
591020006950	dimerization interface [polypeptide binding]; other site
591020006951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
591020006952	Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906
591020006953	Predicted secreted protein [Function unknown]; Region: COG5445
591020006954	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
591020006955	Predicted secreted protein [Function unknown]; Region: COG5445
591020006956	Stage II sporulation protein; Region: SpoIID; pfam08486
591020006957	Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062
591020006958	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
591020006959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234
591020006960	DNA gyrase subunit A; Validated; Region: PRK05560
591020006961	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
591020006962	CAP-like domain; other site
591020006963	active site
591020006964	primary dimer interface [polypeptide binding]; other site
591020006965	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591020006966	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591020006967	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591020006968	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591020006969	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591020006970	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591020006971	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
591020006972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020006973	S-adenosylmethionine binding site [chemical binding]; other site
591020006974	Transposase; Region: HTH_Tnp_1; cl17663
591020006975	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020006976	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020006977	HTH-like domain; Region: HTH_21; pfam13276
591020006978	Integrase core domain; Region: rve; pfam00665
591020006979	Integrase core domain; Region: rve_3; pfam13683
591020006980	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
591020006981	ATP cone domain; Region: ATP-cone; pfam03477
591020006982	Class I ribonucleotide reductase; Region: RNR_I; cd01679
591020006983	active site
591020006984	dimer interface [polypeptide binding]; other site
591020006985	catalytic residues [active]
591020006986	effector binding site; other site
591020006987	R2 peptide binding site; other site
591020006988	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
591020006989	dimer interface [polypeptide binding]; other site
591020006990	putative radical transfer pathway; other site
591020006991	diiron center [ion binding]; other site
591020006992	tyrosyl radical; other site
591020006993	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
591020006994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591020006995	catalytic loop [active]
591020006996	iron binding site [ion binding]; other site
591020006997	hypothetical protein; Provisional; Region: PRK09902
591020006998	hypothetical protein; Provisional; Region: PRK09729
591020006999	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
591020007000	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
591020007001	active site
591020007002	catalytic site [active]
591020007003	metal binding site [ion binding]; metal-binding site
591020007004	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
591020007005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020007006	putative substrate translocation pore; other site
591020007007	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
591020007008	hydroxyglutarate oxidase; Provisional; Region: PRK11728
591020007009	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
591020007010	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
591020007011	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
591020007012	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
591020007013	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
591020007014	Cysteine-rich domain; Region: CCG; pfam02754
591020007015	Cysteine-rich domain; Region: CCG; pfam02754
591020007016	hypothetical protein; Provisional; Region: PRK09956
591020007017	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591020007018	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
591020007019	hypothetical protein; Provisional; Region: PRK03673
591020007020	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
591020007021	putative MPT binding site; other site
591020007022	Competence-damaged protein; Region: CinA; cl00666
591020007023	YfaZ precursor; Region: YfaZ; pfam07437
591020007024	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
591020007025	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
591020007026	catalytic core [active]
591020007027	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
591020007028	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
591020007029	inhibitor-cofactor binding pocket; inhibition site
591020007030	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020007031	catalytic residue [active]
591020007032	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
591020007033	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
591020007034	Ligand binding site; other site
591020007035	Putative Catalytic site; other site
591020007036	DXD motif; other site
591020007037	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
591020007038	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
591020007039	active site
591020007040	hexamer interface [polypeptide binding]; other site
591020007041	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
591020007042	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
591020007043	NAD binding site [chemical binding]; other site
591020007044	substrate binding site [chemical binding]; other site
591020007045	active site
591020007046	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
591020007047	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
591020007048	putative active site [active]
591020007049	putative catalytic site [active]
591020007050	putative Zn binding site [ion binding]; other site
591020007051	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
591020007052	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
591020007053	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
591020007054	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
591020007055	signal transduction protein PmrD; Provisional; Region: PRK15450
591020007056	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
591020007057	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
591020007058	acyl-activating enzyme (AAE) consensus motif; other site
591020007059	putative AMP binding site [chemical binding]; other site
591020007060	putative active site [active]
591020007061	putative CoA binding site [chemical binding]; other site
591020007062	O-succinylbenzoate synthase; Provisional; Region: PRK05105
591020007063	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
591020007064	active site
591020007065	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591020007066	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
591020007067	substrate binding site [chemical binding]; other site
591020007068	oxyanion hole (OAH) forming residues; other site
591020007069	trimer interface [polypeptide binding]; other site
591020007070	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
591020007071	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
591020007072	catalytic site [active]
591020007073	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
591020007074	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
591020007075	dimer interface [polypeptide binding]; other site
591020007076	tetramer interface [polypeptide binding]; other site
591020007077	PYR/PP interface [polypeptide binding]; other site
591020007078	TPP binding site [chemical binding]; other site
591020007079	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
591020007080	TPP-binding site; other site
591020007081	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
591020007082	isochorismate synthases; Region: isochor_syn; TIGR00543
591020007083	hypothetical protein; Provisional; Region: PRK10404
591020007084	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020007085	Coenzyme A binding pocket [chemical binding]; other site
591020007086	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
591020007087	deubiquitinase; Provisional; Region: PRK11836; cl08202
591020007088	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020007089	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
591020007090	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
591020007091	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
591020007092	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
591020007093	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591020007094	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
591020007095	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591020007096	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
591020007097	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
591020007098	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591020007099	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
591020007100	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
591020007101	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
591020007102	4Fe-4S binding domain; Region: Fer4; pfam00037
591020007103	4Fe-4S binding domain; Region: Fer4; pfam00037
591020007104	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
591020007105	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
591020007106	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591020007107	catalytic loop [active]
591020007108	iron binding site [ion binding]; other site
591020007109	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
591020007110	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
591020007111	[4Fe-4S] binding site [ion binding]; other site
591020007112	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
591020007113	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
591020007114	SLBB domain; Region: SLBB; pfam10531
591020007115	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
591020007116	NADH dehydrogenase subunit E; Validated; Region: PRK07539
591020007117	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
591020007118	putative dimer interface [polypeptide binding]; other site
591020007119	[2Fe-2S] cluster binding site [ion binding]; other site
591020007120	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
591020007121	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
591020007122	NADH dehydrogenase subunit D; Validated; Region: PRK06075
591020007123	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
591020007124	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
591020007125	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
591020007126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020007127	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
591020007128	putative dimerization interface [polypeptide binding]; other site
591020007129	aminotransferase AlaT; Validated; Region: PRK09265
591020007130	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591020007131	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020007132	homodimer interface [polypeptide binding]; other site
591020007133	catalytic residue [active]
591020007134	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591020007135	Zn2+ binding site [ion binding]; other site
591020007136	Mg2+ binding site [ion binding]; other site
591020007137	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
591020007138	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591020007139	TrkA-C domain; Region: TrkA_C; pfam02080
591020007140	TrkA-C domain; Region: TrkA_C; pfam02080
591020007141	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
591020007142	putative phosphatase; Provisional; Region: PRK11587
591020007143	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
591020007144	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020007145	motif II; other site
591020007146	hypothetical protein; Validated; Region: PRK05445
591020007147	hypothetical protein; Provisional; Region: PRK01816
591020007148	propionate/acetate kinase; Provisional; Region: PRK12379
591020007149	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
591020007150	phosphate acetyltransferase; Reviewed; Region: PRK05632
591020007151	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
591020007152	DRTGG domain; Region: DRTGG; pfam07085
591020007153	phosphate acetyltransferase; Region: pta; TIGR00651
591020007154	hypothetical protein; Provisional; Region: PRK11588
591020007155	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
591020007156	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
591020007157	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
591020007158	nudix motif; other site
591020007159	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
591020007160	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591020007161	active site
591020007162	metal binding site [ion binding]; metal-binding site
591020007163	homotetramer interface [polypeptide binding]; other site
591020007164	glutathione S-transferase; Provisional; Region: PRK15113
591020007165	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
591020007166	C-terminal domain interface [polypeptide binding]; other site
591020007167	GSH binding site (G-site) [chemical binding]; other site
591020007168	dimer interface [polypeptide binding]; other site
591020007169	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
591020007170	N-terminal domain interface [polypeptide binding]; other site
591020007171	putative dimer interface [polypeptide binding]; other site
591020007172	putative substrate binding pocket (H-site) [chemical binding]; other site
591020007173	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
591020007174	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
591020007175	C-terminal domain interface [polypeptide binding]; other site
591020007176	GSH binding site (G-site) [chemical binding]; other site
591020007177	dimer interface [polypeptide binding]; other site
591020007178	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
591020007179	N-terminal domain interface [polypeptide binding]; other site
591020007180	putative dimer interface [polypeptide binding]; other site
591020007181	active site
591020007182	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
591020007183	homooctamer interface [polypeptide binding]; other site
591020007184	active site
591020007185	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
591020007186	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
591020007187	putative NAD(P) binding site [chemical binding]; other site
591020007188	putative active site [active]
591020007189	putative transposase; Provisional; Region: PRK09857
591020007190	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591020007191	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
591020007192	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591020007193	Walker A/P-loop; other site
591020007194	ATP binding site [chemical binding]; other site
591020007195	Q-loop/lid; other site
591020007196	ABC transporter signature motif; other site
591020007197	Walker B; other site
591020007198	D-loop; other site
591020007199	H-loop/switch region; other site
591020007200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020007201	dimer interface [polypeptide binding]; other site
591020007202	conserved gate region; other site
591020007203	putative PBP binding loops; other site
591020007204	ABC-ATPase subunit interface; other site
591020007205	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591020007206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020007207	dimer interface [polypeptide binding]; other site
591020007208	conserved gate region; other site
591020007209	putative PBP binding loops; other site
591020007210	ABC-ATPase subunit interface; other site
591020007211	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
591020007212	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020007213	substrate binding pocket [chemical binding]; other site
591020007214	membrane-bound complex binding site; other site
591020007215	hinge residues; other site
591020007216	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
591020007217	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020007218	substrate binding pocket [chemical binding]; other site
591020007219	membrane-bound complex binding site; other site
591020007220	hinge residues; other site
591020007221	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
591020007222	Flavoprotein; Region: Flavoprotein; pfam02441
591020007223	amidophosphoribosyltransferase; Provisional; Region: PRK09246
591020007224	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
591020007225	active site
591020007226	tetramer interface [polypeptide binding]; other site
591020007227	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020007228	active site
591020007229	colicin V production protein; Provisional; Region: PRK10845
591020007230	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
591020007231	cell division protein DedD; Provisional; Region: PRK11633
591020007232	Sporulation related domain; Region: SPOR; pfam05036
591020007233	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
591020007234	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591020007235	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591020007236	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
591020007237	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
591020007238	hypothetical protein; Provisional; Region: PRK10847
591020007239	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591020007240	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
591020007241	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
591020007242	dimerization interface 3.5A [polypeptide binding]; other site
591020007243	active site
591020007244	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
591020007245	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
591020007246	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
591020007247	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
591020007248	ligand binding site [chemical binding]; other site
591020007249	NAD binding site [chemical binding]; other site
591020007250	catalytic site [active]
591020007251	homodimer interface [polypeptide binding]; other site
591020007252	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
591020007253	putative transporter; Provisional; Region: PRK12382
591020007254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020007255	putative substrate translocation pore; other site
591020007256	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
591020007257	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
591020007258	dimer interface [polypeptide binding]; other site
591020007259	active site
591020007260	Uncharacterized conserved protein [Function unknown]; Region: COG4121
591020007261	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
591020007262	YfcL protein; Region: YfcL; pfam08891
591020007263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
591020007264	hypothetical protein; Provisional; Region: PRK10621
591020007265	Predicted permeases [General function prediction only]; Region: COG0730
591020007266	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
591020007267	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
591020007268	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
591020007269	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
591020007270	Tetramer interface [polypeptide binding]; other site
591020007271	active site
591020007272	FMN-binding site [chemical binding]; other site
591020007273	HemK family putative methylases; Region: hemK_fam; TIGR00536
591020007274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020007275	S-adenosylmethionine binding site [chemical binding]; other site
591020007276	hypothetical protein; Provisional; Region: PRK04946
591020007277	Smr domain; Region: Smr; pfam01713
591020007278	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
591020007279	Fimbrial protein; Region: Fimbrial; cl01416
591020007280	Fimbrial protein; Region: Fimbrial; cl01416
591020007281	Fimbrial protein; Region: Fimbrial; cl01416
591020007282	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591020007283	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020007284	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591020007285	catalytic core [active]
591020007286	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
591020007287	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591020007288	substrate binding site [chemical binding]; other site
591020007289	oxyanion hole (OAH) forming residues; other site
591020007290	trimer interface [polypeptide binding]; other site
591020007291	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
591020007292	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
591020007293	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
591020007294	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
591020007295	dimer interface [polypeptide binding]; other site
591020007296	active site
591020007297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
591020007298	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
591020007299	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
591020007300	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
591020007301	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020007302	putative transposase OrfB; Reviewed; Region: PHA02517
591020007303	HTH-like domain; Region: HTH_21; pfam13276
591020007304	Integrase core domain; Region: rve; pfam00665
591020007305	Integrase core domain; Region: rve_3; pfam13683
591020007306	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020007307	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020007308	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
591020007309	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
591020007310	substrate binding [chemical binding]; other site
591020007311	active site
591020007312	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
591020007313	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020007314	DNA binding site [nucleotide binding]
591020007315	domain linker motif; other site
591020007316	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
591020007317	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
591020007318	putative dimerization interface [polypeptide binding]; other site
591020007319	putative ligand binding site [chemical binding]; other site
591020007320	fructuronate transporter; Provisional; Region: PRK10034; cl15264
591020007321	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
591020007322	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
591020007323	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591020007324	catalytic residue [active]
591020007325	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
591020007326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020007327	putative substrate translocation pore; other site
591020007328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020007329	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
591020007330	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020007331	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
591020007332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020007333	active site
591020007334	phosphorylation site [posttranslational modification]
591020007335	intermolecular recognition site; other site
591020007336	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020007337	DNA binding residues [nucleotide binding]
591020007338	dimerization interface [polypeptide binding]; other site
591020007339	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
591020007340	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020007341	substrate binding pocket [chemical binding]; other site
591020007342	membrane-bound complex binding site; other site
591020007343	hinge residues; other site
591020007344	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020007345	substrate binding pocket [chemical binding]; other site
591020007346	membrane-bound complex binding site; other site
591020007347	hinge residues; other site
591020007348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020007349	dimer interface [polypeptide binding]; other site
591020007350	phosphorylation site [posttranslational modification]
591020007351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020007352	ATP binding site [chemical binding]; other site
591020007353	Mg2+ binding site [ion binding]; other site
591020007354	G-X-G motif; other site
591020007355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020007356	active site
591020007357	phosphorylation site [posttranslational modification]
591020007358	intermolecular recognition site; other site
591020007359	dimerization interface [polypeptide binding]; other site
591020007360	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591020007361	putative binding surface; other site
591020007362	active site
591020007363	putative CoA-transferase; Provisional; Region: PRK11430
591020007364	CoA-transferase family III; Region: CoA_transf_3; pfam02515
591020007365	putative transporter YfdV; Provisional; Region: PRK09903
591020007366	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
591020007367	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591020007368	PYR/PP interface [polypeptide binding]; other site
591020007369	dimer interface [polypeptide binding]; other site
591020007370	TPP binding site [chemical binding]; other site
591020007371	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591020007372	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
591020007373	TPP-binding site; other site
591020007374	dimer interface [polypeptide binding]; other site
591020007375	formyl-coenzyme A transferase; Provisional; Region: PRK05398
591020007376	CoA-transferase family III; Region: CoA_transf_3; pfam02515
591020007377	hypothetical protein; Provisional; Region: PRK10316
591020007378	YfdX protein; Region: YfdX; pfam10938
591020007379	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
591020007380	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
591020007381	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
591020007382	putative acyl-acceptor binding pocket; other site
591020007383	aminotransferase; Validated; Region: PRK08175
591020007384	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591020007385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020007386	homodimer interface [polypeptide binding]; other site
591020007387	catalytic residue [active]
591020007388	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
591020007389	GAF domain; Region: GAF; pfam01590
591020007390	Histidine kinase; Region: His_kinase; pfam06580
591020007391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020007392	ATP binding site [chemical binding]; other site
591020007393	Mg2+ binding site [ion binding]; other site
591020007394	G-X-G motif; other site
591020007395	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
591020007396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020007397	active site
591020007398	phosphorylation site [posttranslational modification]
591020007399	intermolecular recognition site; other site
591020007400	dimerization interface [polypeptide binding]; other site
591020007401	LytTr DNA-binding domain; Region: LytTR; pfam04397
591020007402	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591020007403	dimerization domain swap beta strand [polypeptide binding]; other site
591020007404	regulatory protein interface [polypeptide binding]; other site
591020007405	active site
591020007406	regulatory phosphorylation site [posttranslational modification]; other site
591020007407	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591020007408	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
591020007409	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591020007410	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591020007411	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020007412	active site
591020007413	phosphorylation site [posttranslational modification]
591020007414	exoaminopeptidase; Provisional; Region: PRK09961
591020007415	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
591020007416	oligomer interface [polypeptide binding]; other site
591020007417	active site
591020007418	metal binding site [ion binding]; metal-binding site
591020007419	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
591020007420	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
591020007421	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
591020007422	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591020007423	active site
591020007424	P-loop; other site
591020007425	phosphorylation site [posttranslational modification]
591020007426	glucokinase, proteobacterial type; Region: glk; TIGR00749
591020007427	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591020007428	nucleotide binding site [chemical binding]; other site
591020007429	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
591020007430	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
591020007431	Cl- selectivity filter; other site
591020007432	Cl- binding residues [ion binding]; other site
591020007433	pore gating glutamate residue; other site
591020007434	dimer interface [polypeptide binding]; other site
591020007435	manganese transport protein MntH; Reviewed; Region: PRK00701
591020007436	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
591020007437	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
591020007438	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
591020007439	Nucleoside recognition; Region: Gate; pfam07670
591020007440	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
591020007441	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
591020007442	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
591020007443	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
591020007444	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
591020007445	active site
591020007446	HIGH motif; other site
591020007447	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
591020007448	active site
591020007449	KMSKS motif; other site
591020007450	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591020007451	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020007452	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
591020007453	putative dimerization interface [polypeptide binding]; other site
591020007454	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
591020007455	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
591020007456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
591020007457	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
591020007458	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
591020007459	nucleotide binding pocket [chemical binding]; other site
591020007460	K-X-D-G motif; other site
591020007461	catalytic site [active]
591020007462	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
591020007463	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
591020007464	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
591020007465	Dimer interface [polypeptide binding]; other site
591020007466	BRCT sequence motif; other site
591020007467	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
591020007468	cell division protein ZipA; Provisional; Region: PRK03427
591020007469	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
591020007470	FtsZ protein binding site [polypeptide binding]; other site
591020007471	putative sulfate transport protein CysZ; Validated; Region: PRK04949
591020007472	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
591020007473	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
591020007474	dimer interface [polypeptide binding]; other site
591020007475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020007476	catalytic residue [active]
591020007477	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591020007478	dimerization domain swap beta strand [polypeptide binding]; other site
591020007479	regulatory protein interface [polypeptide binding]; other site
591020007480	active site
591020007481	regulatory phosphorylation site [posttranslational modification]; other site
591020007482	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
591020007483	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591020007484	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591020007485	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591020007486	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
591020007487	HPr interaction site; other site
591020007488	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591020007489	active site
591020007490	phosphorylation site [posttranslational modification]
591020007491	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
591020007492	dimer interface [polypeptide binding]; other site
591020007493	pyridoxamine kinase; Validated; Region: PRK05756
591020007494	pyridoxal binding site [chemical binding]; other site
591020007495	ATP binding site [chemical binding]; other site
591020007496	hypothetical protein; Provisional; Region: PRK10318
591020007497	cysteine synthase B; Region: cysM; TIGR01138
591020007498	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
591020007499	dimer interface [polypeptide binding]; other site
591020007500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020007501	catalytic residue [active]
591020007502	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
591020007503	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
591020007504	Walker A/P-loop; other site
591020007505	ATP binding site [chemical binding]; other site
591020007506	Q-loop/lid; other site
591020007507	ABC transporter signature motif; other site
591020007508	Walker B; other site
591020007509	D-loop; other site
591020007510	H-loop/switch region; other site
591020007511	TOBE-like domain; Region: TOBE_3; pfam12857
591020007512	sulfate transport protein; Provisional; Region: cysT; CHL00187
591020007513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020007514	dimer interface [polypeptide binding]; other site
591020007515	conserved gate region; other site
591020007516	putative PBP binding loops; other site
591020007517	ABC-ATPase subunit interface; other site
591020007518	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
591020007519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020007520	dimer interface [polypeptide binding]; other site
591020007521	conserved gate region; other site
591020007522	putative PBP binding loops; other site
591020007523	ABC-ATPase subunit interface; other site
591020007524	thiosulfate transporter subunit; Provisional; Region: PRK10852
591020007525	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
591020007526	short chain dehydrogenase; Provisional; Region: PRK08226
591020007527	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
591020007528	NAD binding site [chemical binding]; other site
591020007529	homotetramer interface [polypeptide binding]; other site
591020007530	homodimer interface [polypeptide binding]; other site
591020007531	active site
591020007532	transcriptional regulator MurR; Provisional; Region: PRK15482
591020007533	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591020007534	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591020007535	putative active site [active]
591020007536	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
591020007537	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
591020007538	putative active site [active]
591020007539	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
591020007540	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591020007541	active site turn [active]
591020007542	phosphorylation site [posttranslational modification]
591020007543	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591020007544	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
591020007545	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
591020007546	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
591020007547	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
591020007548	putative acetyltransferase; Provisional; Region: PRK03624
591020007549	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020007550	Coenzyme A binding pocket [chemical binding]; other site
591020007551	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
591020007552	active site
591020007553	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
591020007554	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
591020007555	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020007556	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591020007557	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020007558	carboxysome structural protein EutK; Provisional; Region: PRK15466
591020007559	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
591020007560	Hexamer interface [polypeptide binding]; other site
591020007561	Hexagonal pore residue; other site
591020007562	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
591020007563	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
591020007564	putative hexamer interface [polypeptide binding]; other site
591020007565	putative hexagonal pore; other site
591020007566	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
591020007567	putative hexamer interface [polypeptide binding]; other site
591020007568	putative hexagonal pore; other site
591020007569	HNH endonuclease; Region: HNH_3; pfam13392
591020007570	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591020007571	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
591020007572	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
591020007573	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
591020007574	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
591020007575	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
591020007576	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
591020007577	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
591020007578	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
591020007579	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
591020007580	putative hexamer interface [polypeptide binding]; other site
591020007581	putative hexagonal pore; other site
591020007582	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
591020007583	Malic enzyme, N-terminal domain; Region: malic; pfam00390
591020007584	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
591020007585	putative NAD(P) binding site [chemical binding]; other site
591020007586	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
591020007587	transaldolase-like protein; Provisional; Region: PTZ00411
591020007588	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
591020007589	active site
591020007590	dimer interface [polypeptide binding]; other site
591020007591	catalytic residue [active]
591020007592	transketolase; Reviewed; Region: PRK12753
591020007593	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
591020007594	TPP-binding site [chemical binding]; other site
591020007595	dimer interface [polypeptide binding]; other site
591020007596	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591020007597	PYR/PP interface [polypeptide binding]; other site
591020007598	dimer interface [polypeptide binding]; other site
591020007599	TPP binding site [chemical binding]; other site
591020007600	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
591020007601	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
591020007602	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
591020007603	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
591020007604	dimer interface [polypeptide binding]; other site
591020007605	ADP-ribose binding site [chemical binding]; other site
591020007606	active site
591020007607	nudix motif; other site
591020007608	metal binding site [ion binding]; metal-binding site
591020007609	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
591020007610	4Fe-4S binding domain; Region: Fer4; pfam00037
591020007611	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
591020007612	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020007613	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
591020007614	Protein export membrane protein; Region: SecD_SecF; cl14618
591020007615	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
591020007616	ArsC family; Region: ArsC; pfam03960
591020007617	putative catalytic residues [active]
591020007618	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
591020007619	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
591020007620	metal binding site [ion binding]; metal-binding site
591020007621	dimer interface [polypeptide binding]; other site
591020007622	putative hydrolase; Provisional; Region: PRK11460
591020007623	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
591020007624	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
591020007625	Helicase; Region: Helicase_RecD; pfam05127
591020007626	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
591020007627	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
591020007628	Predicted metalloprotease [General function prediction only]; Region: COG2321
591020007629	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
591020007630	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
591020007631	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
591020007632	ATP binding site [chemical binding]; other site
591020007633	active site
591020007634	substrate binding site [chemical binding]; other site
591020007635	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
591020007636	lipoprotein; Provisional; Region: PRK11679
591020007637	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
591020007638	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
591020007639	dihydrodipicolinate synthase; Region: dapA; TIGR00674
591020007640	dimer interface [polypeptide binding]; other site
591020007641	active site
591020007642	catalytic residue [active]
591020007643	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
591020007644	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
591020007645	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
591020007646	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
591020007647	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
591020007648	catalytic triad [active]
591020007649	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
591020007650	4Fe-4S binding domain; Region: Fer4; pfam00037
591020007651	hydrogenase 4 subunit B; Validated; Region: PRK06521
591020007652	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591020007653	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
591020007654	NADH dehydrogenase; Region: NADHdh; cl00469
591020007655	hydrogenase 4 subunit D; Validated; Region: PRK06525
591020007656	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591020007657	hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492
591020007658	hydrogenase 4 subunit F; Validated; Region: PRK06458
591020007659	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591020007660	hydrogenase 4 subunit H; Validated; Region: PRK08222
591020007661	4Fe-4S binding domain; Region: Fer4; pfam00037
591020007662	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
591020007663	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
591020007664	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
591020007665	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591020007666	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
591020007667	Peptidase family M48; Region: Peptidase_M48; cl12018
591020007668	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
591020007669	ArsC family; Region: ArsC; pfam03960
591020007670	catalytic residues [active]
591020007671	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
591020007672	DNA replication initiation factor; Provisional; Region: PRK08084
591020007673	uracil transporter; Provisional; Region: PRK10720
591020007674	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020007675	active site
591020007676	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
591020007677	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
591020007678	dimerization interface [polypeptide binding]; other site
591020007679	putative ATP binding site [chemical binding]; other site
591020007680	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
591020007681	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
591020007682	active site
591020007683	substrate binding site [chemical binding]; other site
591020007684	cosubstrate binding site; other site
591020007685	catalytic site [active]
591020007686	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
591020007687	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
591020007688	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
591020007689	Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114
591020007690	domain interface [polypeptide binding]; other site
591020007691	active site
591020007692	catalytic site [active]
591020007693	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
591020007694	putative active site [active]
591020007695	catalytic site [active]
591020007696	exopolyphosphatase; Provisional; Region: PRK10854
591020007697	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
591020007698	putative transposase OrfB; Reviewed; Region: PHA02517
591020007699	Integrase core domain; Region: rve; pfam00665
591020007700	Integrase core domain; Region: rve_3; pfam13683
591020007701	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
591020007702	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
591020007703	GMP synthase; Reviewed; Region: guaA; PRK00074
591020007704	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
591020007705	AMP/PPi binding site [chemical binding]; other site
591020007706	candidate oxyanion hole; other site
591020007707	catalytic triad [active]
591020007708	potential glutamine specificity residues [chemical binding]; other site
591020007709	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
591020007710	ATP Binding subdomain [chemical binding]; other site
591020007711	Ligand Binding sites [chemical binding]; other site
591020007712	Dimerization subdomain; other site
591020007713	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
591020007714	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591020007715	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
591020007716	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
591020007717	active site
591020007718	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
591020007719	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
591020007720	generic binding surface II; other site
591020007721	generic binding surface I; other site
591020007722	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
591020007723	GTP-binding protein Der; Reviewed; Region: PRK00093
591020007724	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
591020007725	G1 box; other site
591020007726	GTP/Mg2+ binding site [chemical binding]; other site
591020007727	Switch I region; other site
591020007728	G2 box; other site
591020007729	Switch II region; other site
591020007730	G3 box; other site
591020007731	G4 box; other site
591020007732	G5 box; other site
591020007733	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
591020007734	G1 box; other site
591020007735	GTP/Mg2+ binding site [chemical binding]; other site
591020007736	Switch I region; other site
591020007737	G2 box; other site
591020007738	G3 box; other site
591020007739	Switch II region; other site
591020007740	G4 box; other site
591020007741	G5 box; other site
591020007742	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
591020007743	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216
591020007744	Trp docking motif [polypeptide binding]; other site
591020007745	active site
591020007746	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
591020007747	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
591020007748	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
591020007749	dimer interface [polypeptide binding]; other site
591020007750	motif 1; other site
591020007751	active site
591020007752	motif 2; other site
591020007753	motif 3; other site
591020007754	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
591020007755	anticodon binding site; other site
591020007756	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
591020007757	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
591020007758	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
591020007759	cytoskeletal protein RodZ; Provisional; Region: PRK10856
591020007760	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020007761	non-specific DNA binding site [nucleotide binding]; other site
591020007762	salt bridge; other site
591020007763	sequence-specific DNA binding site [nucleotide binding]; other site
591020007764	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
591020007765	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
591020007766	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020007767	FeS/SAM binding site; other site
591020007768	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
591020007769	active site
591020007770	multimer interface [polypeptide binding]; other site
591020007771	penicillin-binding protein 1C; Provisional; Region: PRK11240
591020007772	Transglycosylase; Region: Transgly; pfam00912
591020007773	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591020007774	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
591020007775	Transposase; Region: DEDD_Tnp_IS110; pfam01548
591020007776	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020007777	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
591020007778	active site residue [active]
591020007779	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
591020007780	aminopeptidase B; Provisional; Region: PRK05015
591020007781	Peptidase; Region: DUF3663; pfam12404
591020007782	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
591020007783	interface (dimer of trimers) [polypeptide binding]; other site
591020007784	Substrate-binding/catalytic site; other site
591020007785	Zn-binding sites [ion binding]; other site
591020007786	hypothetical protein; Provisional; Region: PRK10721
591020007787	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
591020007788	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591020007789	catalytic loop [active]
591020007790	iron binding site [ion binding]; other site
591020007791	chaperone protein HscA; Provisional; Region: hscA; PRK05183
591020007792	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
591020007793	nucleotide binding site [chemical binding]; other site
591020007794	putative NEF/HSP70 interaction site [polypeptide binding]; other site
591020007795	SBD interface [polypeptide binding]; other site
591020007796	co-chaperone HscB; Provisional; Region: hscB; PRK05014
591020007797	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
591020007798	HSP70 interaction site [polypeptide binding]; other site
591020007799	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
591020007800	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
591020007801	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
591020007802	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
591020007803	trimerization site [polypeptide binding]; other site
591020007804	active site
591020007805	cysteine desulfurase; Provisional; Region: PRK14012
591020007806	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
591020007807	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591020007808	catalytic residue [active]
591020007809	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
591020007810	Rrf2 family protein; Region: rrf2_super; TIGR00738
591020007811	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
591020007812	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
591020007813	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
591020007814	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
591020007815	active site
591020007816	dimerization interface [polypeptide binding]; other site
591020007817	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
591020007818	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591020007819	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
591020007820	PRD domain; Region: PRD; pfam00874
591020007821	PRD domain; Region: PRD; pfam00874
591020007822	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
591020007823	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
591020007824	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020007825	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020007826	dimerization interface [polypeptide binding]; other site
591020007827	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
591020007828	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
591020007829	iron-sulfur cluster [ion binding]; other site
591020007830	[2Fe-2S] cluster binding site [ion binding]; other site
591020007831	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
591020007832	beta subunit interface [polypeptide binding]; other site
591020007833	alpha subunit interface [polypeptide binding]; other site
591020007834	active site
591020007835	substrate binding site [chemical binding]; other site
591020007836	Fe binding site [ion binding]; other site
591020007837	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
591020007838	inter-subunit interface; other site
591020007839	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
591020007840	[2Fe-2S] cluster binding site [ion binding]; other site
591020007841	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
591020007842	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
591020007843	NAD binding site [chemical binding]; other site
591020007844	active site
591020007845	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
591020007846	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020007847	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
591020007848	active site
591020007849	catalytic residues [active]
591020007850	L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239
591020007851	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591020007852	putative NAD(P) binding site [chemical binding]; other site
591020007853	catalytic Zn binding site [ion binding]; other site
591020007854	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020007855	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020007856	TM-ABC transporter signature motif; other site
591020007857	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
591020007858	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591020007859	Walker A/P-loop; other site
591020007860	ATP binding site [chemical binding]; other site
591020007861	Q-loop/lid; other site
591020007862	ABC transporter signature motif; other site
591020007863	Walker B; other site
591020007864	D-loop; other site
591020007865	H-loop/switch region; other site
591020007866	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591020007867	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
591020007868	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
591020007869	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591020007870	nucleotide binding site [chemical binding]; other site
591020007871	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
591020007872	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
591020007873	dimer interface [polypeptide binding]; other site
591020007874	active site
591020007875	glycine-pyridoxal phosphate binding site [chemical binding]; other site
591020007876	folate binding site [chemical binding]; other site
591020007877	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
591020007878	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
591020007879	heme-binding site [chemical binding]; other site
591020007880	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
591020007881	FAD binding pocket [chemical binding]; other site
591020007882	FAD binding motif [chemical binding]; other site
591020007883	phosphate binding motif [ion binding]; other site
591020007884	beta-alpha-beta structure motif; other site
591020007885	NAD binding pocket [chemical binding]; other site
591020007886	Heme binding  pocket [chemical binding]; other site
591020007887	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
591020007888	Nitrogen regulatory protein P-II; Region: P-II; smart00938
591020007889	response regulator GlrR; Provisional; Region: PRK15115
591020007890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020007891	active site
591020007892	phosphorylation site [posttranslational modification]
591020007893	intermolecular recognition site; other site
591020007894	dimerization interface [polypeptide binding]; other site
591020007895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020007896	Walker A motif; other site
591020007897	ATP binding site [chemical binding]; other site
591020007898	Walker B motif; other site
591020007899	arginine finger; other site
591020007900	hypothetical protein; Provisional; Region: PRK10722
591020007901	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
591020007902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020007903	dimer interface [polypeptide binding]; other site
591020007904	phosphorylation site [posttranslational modification]
591020007905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020007906	ATP binding site [chemical binding]; other site
591020007907	Mg2+ binding site [ion binding]; other site
591020007908	G-X-G motif; other site
591020007909	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
591020007910	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
591020007911	dimerization interface [polypeptide binding]; other site
591020007912	ATP binding site [chemical binding]; other site
591020007913	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
591020007914	dimerization interface [polypeptide binding]; other site
591020007915	ATP binding site [chemical binding]; other site
591020007916	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
591020007917	putative active site [active]
591020007918	catalytic triad [active]
591020007919	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
591020007920	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020007921	substrate binding pocket [chemical binding]; other site
591020007922	membrane-bound complex binding site; other site
591020007923	hinge residues; other site
591020007924	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020007925	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020007926	catalytic residue [active]
591020007927	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
591020007928	nucleoside/Zn binding site; other site
591020007929	dimer interface [polypeptide binding]; other site
591020007930	catalytic motif [active]
591020007931	hypothetical protein; Provisional; Region: PRK11590
591020007932	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
591020007933	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
591020007934	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
591020007935	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
591020007936	putative active site [active]
591020007937	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
591020007938	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
591020007939	catalytic residues [active]
591020007940	catalytic nucleophile [active]
591020007941	Presynaptic Site I dimer interface [polypeptide binding]; other site
591020007942	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
591020007943	Synaptic Flat tetramer interface [polypeptide binding]; other site
591020007944	Synaptic Site I dimer interface [polypeptide binding]; other site
591020007945	DNA binding site [nucleotide binding]
591020007946	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
591020007947	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
591020007948	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
591020007949	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
591020007950	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
591020007951	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020007952	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020007953	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020007954	HTH-like domain; Region: HTH_21; pfam13276
591020007955	Integrase core domain; Region: rve; pfam00665
591020007956	Integrase core domain; Region: rve_3; pfam13683
591020007957	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
591020007958	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
591020007959	putative transposase OrfB; Reviewed; Region: PHA02517
591020007960	Integrase core domain; Region: rve; pfam00665
591020007961	Integrase core domain; Region: rve_3; pfam13683
591020007962	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020007963	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
591020007964	holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516
591020007965	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
591020007966	active site
591020007967	hydrophilic channel; other site
591020007968	dimerization interface [polypeptide binding]; other site
591020007969	catalytic residues [active]
591020007970	active site lid [active]
591020007971	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
591020007972	Recombination protein O N terminal; Region: RecO_N; pfam11967
591020007973	Recombination protein O C terminal; Region: RecO_C; pfam02565
591020007974	GTPase Era; Reviewed; Region: era; PRK00089
591020007975	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
591020007976	G1 box; other site
591020007977	GTP/Mg2+ binding site [chemical binding]; other site
591020007978	Switch I region; other site
591020007979	G2 box; other site
591020007980	Switch II region; other site
591020007981	G3 box; other site
591020007982	G4 box; other site
591020007983	G5 box; other site
591020007984	KH domain; Region: KH_2; pfam07650
591020007985	ribonuclease III; Reviewed; Region: rnc; PRK00102
591020007986	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
591020007987	dimerization interface [polypeptide binding]; other site
591020007988	active site
591020007989	metal binding site [ion binding]; metal-binding site
591020007990	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
591020007991	dsRNA binding site [nucleotide binding]; other site
591020007992	signal peptidase I; Provisional; Region: PRK10861
591020007993	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
591020007994	Catalytic site [active]
591020007995	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
591020007996	GTP-binding protein LepA; Provisional; Region: PRK05433
591020007997	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
591020007998	G1 box; other site
591020007999	putative GEF interaction site [polypeptide binding]; other site
591020008000	GTP/Mg2+ binding site [chemical binding]; other site
591020008001	Switch I region; other site
591020008002	G2 box; other site
591020008003	G3 box; other site
591020008004	Switch II region; other site
591020008005	G4 box; other site
591020008006	G5 box; other site
591020008007	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
591020008008	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
591020008009	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
591020008010	SoxR reducing system protein RseC; Provisional; Region: PRK10862
591020008011	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
591020008012	anti-sigma E factor; Provisional; Region: rseB; PRK09455
591020008013	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
591020008014	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
591020008015	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
591020008016	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
591020008017	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591020008018	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591020008019	DNA binding residues [nucleotide binding]
591020008020	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
591020008021	Methyltransferase domain; Region: Methyltransf_26; pfam13659
591020008022	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
591020008023	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591020008024	ATP binding site [chemical binding]; other site
591020008025	Mg++ binding site [ion binding]; other site
591020008026	motif III; other site
591020008027	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020008028	nucleotide binding region [chemical binding]; other site
591020008029	ATP-binding site [chemical binding]; other site
591020008030	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591020008031	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020008032	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
591020008033	dimerization interface [polypeptide binding]; other site
591020008034	LysE type translocator; Region: LysE; cl00565
591020008035	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
591020008036	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
591020008037	ligand binding site [chemical binding]; other site
591020008038	active site
591020008039	UGI interface [polypeptide binding]; other site
591020008040	catalytic site [active]
591020008041	putative methyltransferase; Provisional; Region: PRK10864
591020008042	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
591020008043	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591020008044	thioredoxin 2; Provisional; Region: PRK10996
591020008045	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
591020008046	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591020008047	catalytic residues [active]
591020008048	Uncharacterized conserved protein [Function unknown]; Region: COG3148
591020008049	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
591020008050	CoA binding domain; Region: CoA_binding_2; pfam13380
591020008051	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
591020008052	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
591020008053	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
591020008054	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
591020008055	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
591020008056	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
591020008057	domain interface [polypeptide binding]; other site
591020008058	putative active site [active]
591020008059	catalytic site [active]
591020008060	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
591020008061	domain interface [polypeptide binding]; other site
591020008062	putative active site [active]
591020008063	catalytic site [active]
591020008064	lipoprotein; Provisional; Region: PRK10759
591020008065	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
591020008066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008067	putative substrate translocation pore; other site
591020008068	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020008069	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020008070	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
591020008071	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
591020008072	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
591020008073	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020008074	RNA binding surface [nucleotide binding]; other site
591020008075	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
591020008076	active site
591020008077	hypothetical protein; Provisional; Region: PRK10723
591020008078	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
591020008079	protein disaggregation chaperone; Provisional; Region: PRK10865
591020008080	Clp amino terminal domain; Region: Clp_N; pfam02861
591020008081	Clp amino terminal domain; Region: Clp_N; pfam02861
591020008082	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020008083	Walker A motif; other site
591020008084	ATP binding site [chemical binding]; other site
591020008085	Walker B motif; other site
591020008086	arginine finger; other site
591020008087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020008088	Walker A motif; other site
591020008089	ATP binding site [chemical binding]; other site
591020008090	Walker B motif; other site
591020008091	arginine finger; other site
591020008092	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
591020008093	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020008094	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020008095	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
591020008096	30S subunit binding site; other site
591020008097	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
591020008098	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
591020008099	Prephenate dehydratase; Region: PDT; pfam00800
591020008100	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
591020008101	putative L-Phe binding site [chemical binding]; other site
591020008102	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
591020008103	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
591020008104	prephenate dehydrogenase; Validated; Region: PRK08507
591020008105	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
591020008106	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
591020008107	lipoprotein; Provisional; Region: PRK11443
591020008108	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
591020008109	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
591020008110	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
591020008111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020008112	metal binding site [ion binding]; metal-binding site
591020008113	active site
591020008114	I-site; other site
591020008115	putative outer membrane lipoprotein; Provisional; Region: PRK09967
591020008116	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591020008117	ligand binding site [chemical binding]; other site
591020008118	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
591020008119	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
591020008120	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
591020008121	RimM N-terminal domain; Region: RimM; pfam01782
591020008122	PRC-barrel domain; Region: PRC; pfam05239
591020008123	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
591020008124	signal recognition particle protein; Provisional; Region: PRK10867
591020008125	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
591020008126	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
591020008127	P loop; other site
591020008128	GTP binding site [chemical binding]; other site
591020008129	Signal peptide binding domain; Region: SRP_SPB; pfam02978
591020008130	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
591020008131	hypothetical protein; Provisional; Region: PRK11573
591020008132	Domain of unknown function DUF21; Region: DUF21; pfam01595
591020008133	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591020008134	Transporter associated domain; Region: CorC_HlyC; smart01091
591020008135	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
591020008136	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
591020008137	dimer interface [polypeptide binding]; other site
591020008138	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
591020008139	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
591020008140	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
591020008141	recombination and repair protein; Provisional; Region: PRK10869
591020008142	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
591020008143	Walker A/P-loop; other site
591020008144	ATP binding site [chemical binding]; other site
591020008145	Q-loop/lid; other site
591020008146	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
591020008147	Q-loop/lid; other site
591020008148	ABC transporter signature motif; other site
591020008149	Walker B; other site
591020008150	D-loop; other site
591020008151	H-loop/switch region; other site
591020008152	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
591020008153	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
591020008154	hypothetical protein; Validated; Region: PRK01777
591020008155	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
591020008156	putative coenzyme Q binding site [chemical binding]; other site
591020008157	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
591020008158	SmpB-tmRNA interface; other site
591020008159	integrase; Provisional; Region: PRK09692
591020008160	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591020008161	active site
591020008162	Int/Topo IB signature motif; other site
591020008163	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020008164	Transposase; Region: HTH_Tnp_1; cl17663
591020008165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020008166	putative transposase OrfB; Reviewed; Region: PHA02517
591020008167	HTH-like domain; Region: HTH_21; pfam13276
591020008168	Integrase core domain; Region: rve; pfam00665
591020008169	Integrase core domain; Region: rve_2; pfam13333
591020008170	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
591020008171	active site
591020008172	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
591020008173	Ca binding site [ion binding]; other site
591020008174	catalytic site [active]
591020008175	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
591020008176	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
591020008177	substrate binding pocket [chemical binding]; other site
591020008178	active site
591020008179	iron coordination sites [ion binding]; other site
591020008180	Predicted dehydrogenase [General function prediction only]; Region: COG0579
591020008181	hydroxyglutarate oxidase; Provisional; Region: PRK11728
591020008182	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591020008183	acetylornithine transaminase; Region: PLN00144
591020008184	inhibitor-cofactor binding pocket; inhibition site
591020008185	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020008186	catalytic residue [active]
591020008187	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
591020008188	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
591020008189	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020008190	DNA-binding site [nucleotide binding]; DNA binding site
591020008191	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591020008192	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
591020008193	bacterial OsmY and nodulation domain; Region: BON; smart00749
591020008194	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020008195	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
591020008196	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020008197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020008198	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591020008199	dimerization interface [polypeptide binding]; other site
591020008200	putative DNA binding site [nucleotide binding]; other site
591020008201	putative Zn2+ binding site [ion binding]; other site
591020008202	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527
591020008203	active site residue [active]
591020008204	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
591020008205	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
591020008206	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
591020008207	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
591020008208	hypothetical protein; Provisional; Region: PRK10556
591020008209	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
591020008210	catalytic residues [active]
591020008211	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
591020008212	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
591020008213	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
591020008214	Class I ribonucleotide reductase; Region: RNR_I; cd01679
591020008215	active site
591020008216	dimer interface [polypeptide binding]; other site
591020008217	catalytic residues [active]
591020008218	effector binding site; other site
591020008219	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
591020008220	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
591020008221	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
591020008222	dimer interface [polypeptide binding]; other site
591020008223	putative radical transfer pathway; other site
591020008224	diiron center [ion binding]; other site
591020008225	tyrosyl radical; other site
591020008226	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
591020008227	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
591020008228	Walker A/P-loop; other site
591020008229	ATP binding site [chemical binding]; other site
591020008230	Q-loop/lid; other site
591020008231	ABC transporter signature motif; other site
591020008232	Walker B; other site
591020008233	D-loop; other site
591020008234	H-loop/switch region; other site
591020008235	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
591020008236	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
591020008237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020008238	dimer interface [polypeptide binding]; other site
591020008239	conserved gate region; other site
591020008240	putative PBP binding loops; other site
591020008241	ABC-ATPase subunit interface; other site
591020008242	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
591020008243	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
591020008244	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
591020008245	putative L-valine exporter; Provisional; Region: PRK10408
591020008246	transcriptional repressor MprA; Provisional; Region: PRK10870
591020008247	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591020008248	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
591020008249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008250	putative substrate translocation pore; other site
591020008251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008252	S-ribosylhomocysteinase; Provisional; Region: PRK02260
591020008253	glutamate--cysteine ligase; Provisional; Region: PRK02107
591020008254	Predicted membrane protein [Function unknown]; Region: COG1238
591020008255	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
591020008256	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020008257	motif II; other site
591020008258	carbon storage regulator; Provisional; Region: PRK01712
591020008259	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
591020008260	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
591020008261	motif 1; other site
591020008262	active site
591020008263	motif 2; other site
591020008264	motif 3; other site
591020008265	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
591020008266	DHHA1 domain; Region: DHHA1; pfam02272
591020008267	recombination regulator RecX; Reviewed; Region: recX; PRK00117
591020008268	recombinase A; Provisional; Region: recA; PRK09354
591020008269	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
591020008270	hexamer interface [polypeptide binding]; other site
591020008271	Walker A motif; other site
591020008272	ATP binding site [chemical binding]; other site
591020008273	Walker B motif; other site
591020008274	hypothetical protein; Validated; Region: PRK03661
591020008275	Transglycosylase SLT domain; Region: SLT_2; pfam13406
591020008276	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020008277	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020008278	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
591020008279	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
591020008280	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
591020008281	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
591020008282	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
591020008283	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
591020008284	putative NAD(P) binding site [chemical binding]; other site
591020008285	active site
591020008286	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
591020008287	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
591020008288	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591020008289	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020008290	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
591020008291	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
591020008292	putative active site [active]
591020008293	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
591020008294	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
591020008295	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591020008296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020008297	Walker A motif; other site
591020008298	ATP binding site [chemical binding]; other site
591020008299	Walker B motif; other site
591020008300	arginine finger; other site
591020008301	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
591020008302	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
591020008303	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
591020008304	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
591020008305	iron binding site [ion binding]; other site
591020008306	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
591020008307	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591020008308	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020008309	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
591020008310	Acylphosphatase; Region: Acylphosphatase; pfam00708
591020008311	HypF finger; Region: zf-HYPF; pfam07503
591020008312	HypF finger; Region: zf-HYPF; pfam07503
591020008313	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
591020008314	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
591020008315	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
591020008316	Transcriptional regulators [Transcription]; Region: PurR; COG1609
591020008317	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020008318	DNA binding site [nucleotide binding]
591020008319	domain linker motif; other site
591020008320	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
591020008321	dimerization interface (closed form) [polypeptide binding]; other site
591020008322	ligand binding site [chemical binding]; other site
591020008323	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
591020008324	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
591020008325	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
591020008326	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
591020008327	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
591020008328	NADH dehydrogenase; Region: NADHdh; cl00469
591020008329	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
591020008330	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
591020008331	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
591020008332	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
591020008333	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
591020008334	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
591020008335	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
591020008336	hydrogenase assembly chaperone; Provisional; Region: PRK10409
591020008337	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
591020008338	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
591020008339	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
591020008340	dimerization interface [polypeptide binding]; other site
591020008341	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
591020008342	ATP binding site [chemical binding]; other site
591020008343	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
591020008344	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591020008345	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591020008346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020008347	Walker A motif; other site
591020008348	ATP binding site [chemical binding]; other site
591020008349	Walker B motif; other site
591020008350	arginine finger; other site
591020008351	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
591020008352	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020008353	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
591020008354	MutS domain I; Region: MutS_I; pfam01624
591020008355	MutS domain II; Region: MutS_II; pfam05188
591020008356	MutS domain III; Region: MutS_III; pfam05192
591020008357	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
591020008358	Walker A/P-loop; other site
591020008359	ATP binding site [chemical binding]; other site
591020008360	Q-loop/lid; other site
591020008361	ABC transporter signature motif; other site
591020008362	Walker B; other site
591020008363	D-loop; other site
591020008364	H-loop/switch region; other site
591020008365	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591020008366	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
591020008367	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020008368	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
591020008369	putative transposase OrfB; Reviewed; Region: PHA02517
591020008370	Integrase core domain; Region: rve; pfam00665
591020008371	Integrase core domain; Region: rve_3; pfam13683
591020008372	putative transposase OrfB; Reviewed; Region: PHA02517
591020008373	Integrase core domain; Region: rve; pfam00665
591020008374	Integrase core domain; Region: rve_3; pfam13683
591020008375	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
591020008376	Integrase core domain; Region: rve; pfam00665
591020008377	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
591020008378	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
591020008379	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
591020008380	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
591020008381	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
591020008382	Flavoprotein; Region: Flavoprotein; pfam02441
591020008383	MarR family; Region: MarR_2; cl17246
591020008384	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591020008385	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
591020008386	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
591020008387	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591020008388	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
591020008389	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591020008390	DNA binding residues [nucleotide binding]
591020008391	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
591020008392	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020008393	Peptidase family M23; Region: Peptidase_M23; pfam01551
591020008394	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
591020008395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020008396	S-adenosylmethionine binding site [chemical binding]; other site
591020008397	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
591020008398	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
591020008399	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
591020008400	Permutation of conserved domain; other site
591020008401	active site
591020008402	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
591020008403	homotrimer interaction site [polypeptide binding]; other site
591020008404	zinc binding site [ion binding]; other site
591020008405	CDP-binding sites; other site
591020008406	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
591020008407	substrate binding site; other site
591020008408	dimer interface; other site
591020008409	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
591020008410	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
591020008411	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
591020008412	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
591020008413	ligand-binding site [chemical binding]; other site
591020008414	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
591020008415	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
591020008416	CysD dimerization site [polypeptide binding]; other site
591020008417	G1 box; other site
591020008418	putative GEF interaction site [polypeptide binding]; other site
591020008419	GTP/Mg2+ binding site [chemical binding]; other site
591020008420	Switch I region; other site
591020008421	G2 box; other site
591020008422	G3 box; other site
591020008423	Switch II region; other site
591020008424	G4 box; other site
591020008425	G5 box; other site
591020008426	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
591020008427	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
591020008428	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
591020008429	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
591020008430	Active Sites [active]
591020008431	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
591020008432	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
591020008433	metal binding site [ion binding]; metal-binding site
591020008434	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
591020008435	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
591020008436	Hok/gef family; Region: HOK_GEF; pfam01848
591020008437	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
591020008438	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
591020008439	Active Sites [active]
591020008440	sulfite reductase subunit beta; Provisional; Region: PRK13504
591020008441	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
591020008442	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
591020008443	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
591020008444	Flavodoxin; Region: Flavodoxin_1; pfam00258
591020008445	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
591020008446	FAD binding pocket [chemical binding]; other site
591020008447	FAD binding motif [chemical binding]; other site
591020008448	catalytic residues [active]
591020008449	NAD binding pocket [chemical binding]; other site
591020008450	phosphate binding motif [ion binding]; other site
591020008451	beta-alpha-beta structure motif; other site
591020008452	6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470
591020008453	homohexamer interface [polypeptide binding]; other site
591020008454	putative substrate stabilizing pore; other site
591020008455	pterin binding site; other site
591020008456	oxidoreductase; Provisional; Region: PRK10015
591020008457	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
591020008458	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
591020008459	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
591020008460	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
591020008461	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
591020008462	Ligand binding site [chemical binding]; other site
591020008463	Electron transfer flavoprotein domain; Region: ETF; pfam01012
591020008464	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
591020008465	benzoate transport; Region: 2A0115; TIGR00895
591020008466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008467	putative substrate translocation pore; other site
591020008468	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
591020008469	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020008470	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
591020008471	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
591020008472	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020008473	enolase; Provisional; Region: eno; PRK00077
591020008474	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
591020008475	dimer interface [polypeptide binding]; other site
591020008476	metal binding site [ion binding]; metal-binding site
591020008477	substrate binding pocket [chemical binding]; other site
591020008478	CTP synthetase; Validated; Region: pyrG; PRK05380
591020008479	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
591020008480	Catalytic site [active]
591020008481	active site
591020008482	UTP binding site [chemical binding]; other site
591020008483	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
591020008484	active site
591020008485	putative oxyanion hole; other site
591020008486	catalytic triad [active]
591020008487	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
591020008488	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
591020008489	homodimer interface [polypeptide binding]; other site
591020008490	metal binding site [ion binding]; metal-binding site
591020008491	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
591020008492	homodimer interface [polypeptide binding]; other site
591020008493	active site
591020008494	putative chemical substrate binding site [chemical binding]; other site
591020008495	metal binding site [ion binding]; metal-binding site
591020008496	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
591020008497	HD domain; Region: HD_4; pfam13328
591020008498	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
591020008499	synthetase active site [active]
591020008500	NTP binding site [chemical binding]; other site
591020008501	metal binding site [ion binding]; metal-binding site
591020008502	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
591020008503	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
591020008504	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
591020008505	TRAM domain; Region: TRAM; pfam01938
591020008506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020008507	S-adenosylmethionine binding site [chemical binding]; other site
591020008508	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
591020008509	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
591020008510	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020008511	dimerization interface [polypeptide binding]; other site
591020008512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020008513	dimer interface [polypeptide binding]; other site
591020008514	phosphorylation site [posttranslational modification]
591020008515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020008516	ATP binding site [chemical binding]; other site
591020008517	Mg2+ binding site [ion binding]; other site
591020008518	G-X-G motif; other site
591020008519	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
591020008520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020008521	active site
591020008522	phosphorylation site [posttranslational modification]
591020008523	intermolecular recognition site; other site
591020008524	dimerization interface [polypeptide binding]; other site
591020008525	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591020008526	putative binding surface; other site
591020008527	active site
591020008528	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
591020008529	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
591020008530	active site
591020008531	tetramer interface [polypeptide binding]; other site
591020008532	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
591020008533	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
591020008534	active site
591020008535	tetramer interface [polypeptide binding]; other site
591020008536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008537	D-galactonate transporter; Region: 2A0114; TIGR00893
591020008538	putative substrate translocation pore; other site
591020008539	flavodoxin; Provisional; Region: PRK08105
591020008540	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
591020008541	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
591020008542	probable active site [active]
591020008543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
591020008544	SecY interacting protein Syd; Provisional; Region: PRK04968
591020008545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
591020008546	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
591020008547	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
591020008548	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
591020008549	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
591020008550	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591020008551	serine transporter; Region: stp; TIGR00814
591020008552	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
591020008553	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
591020008554	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
591020008555	flap endonuclease-like protein; Provisional; Region: PRK09482
591020008556	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
591020008557	active site
591020008558	metal binding site 1 [ion binding]; metal-binding site
591020008559	putative 5' ssDNA interaction site; other site
591020008560	metal binding site 3; metal-binding site
591020008561	metal binding site 2 [ion binding]; metal-binding site
591020008562	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
591020008563	putative DNA binding site [nucleotide binding]; other site
591020008564	putative metal binding site [ion binding]; other site
591020008565	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
591020008566	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
591020008567	dimer interface [polypeptide binding]; other site
591020008568	active site
591020008569	metal binding site [ion binding]; metal-binding site
591020008570	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591020008571	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
591020008572	intersubunit interface [polypeptide binding]; other site
591020008573	active site
591020008574	Zn2+ binding site [ion binding]; other site
591020008575	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
591020008576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008577	putative substrate translocation pore; other site
591020008578	L-fucose isomerase; Provisional; Region: fucI; PRK10991
591020008579	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
591020008580	hexamer (dimer of trimers) interface [polypeptide binding]; other site
591020008581	trimer interface [polypeptide binding]; other site
591020008582	substrate binding site [chemical binding]; other site
591020008583	Mn binding site [ion binding]; other site
591020008584	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
591020008585	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
591020008586	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591020008587	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020008588	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
591020008589	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
591020008590	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
591020008591	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020008592	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
591020008593	dimerization interface [polypeptide binding]; other site
591020008594	substrate binding pocket [chemical binding]; other site
591020008595	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
591020008596	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
591020008597	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
591020008598	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591020008599	catalytic residue [active]
591020008600	CsdA-binding activator; Provisional; Region: PRK15019
591020008601	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
591020008602	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
591020008603	putative ATP binding site [chemical binding]; other site
591020008604	putative substrate interface [chemical binding]; other site
591020008605	murein transglycosylase A; Provisional; Region: mltA; PRK11162
591020008606	MltA specific insert domain; Region: MltA; pfam03562
591020008607	3D domain; Region: 3D; pfam06725
591020008608	AMIN domain; Region: AMIN; pfam11741
591020008609	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
591020008610	active site
591020008611	metal binding site [ion binding]; metal-binding site
591020008612	N-acetylglutamate synthase; Validated; Region: PRK05279
591020008613	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
591020008614	putative feedback inhibition sensing region; other site
591020008615	putative nucleotide binding site [chemical binding]; other site
591020008616	putative substrate binding site [chemical binding]; other site
591020008617	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020008618	Coenzyme A binding pocket [chemical binding]; other site
591020008619	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
591020008620	AAA domain; Region: AAA_30; pfam13604
591020008621	Family description; Region: UvrD_C_2; pfam13538
591020008622	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
591020008623	protease3; Provisional; Region: PRK15101
591020008624	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
591020008625	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591020008626	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591020008627	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
591020008628	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
591020008629	hypothetical protein; Provisional; Region: PRK10332
591020008630	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
591020008631	hypothetical protein; Provisional; Region: PRK11521
591020008632	hypothetical protein; Provisional; Region: PRK10557
591020008633	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
591020008634	thymidylate synthase; Reviewed; Region: thyA; PRK01827
591020008635	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
591020008636	dimerization interface [polypeptide binding]; other site
591020008637	active site
591020008638	prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544
591020008639	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
591020008640	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
591020008641	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
591020008642	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
591020008643	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
591020008644	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
591020008645	putative active site [active]
591020008646	Ap4A binding site [chemical binding]; other site
591020008647	nudix motif; other site
591020008648	putative metal binding site [ion binding]; other site
591020008649	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
591020008650	putative DNA-binding cleft [nucleotide binding]; other site
591020008651	putative DNA clevage site; other site
591020008652	molecular lever; other site
591020008653	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
591020008654	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
591020008655	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020008656	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020008657	active site
591020008658	catalytic tetrad [active]
591020008659	lysophospholipid transporter LplT; Provisional; Region: PRK11195
591020008660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008661	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
591020008662	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
591020008663	putative acyl-acceptor binding pocket; other site
591020008664	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
591020008665	acyl-activating enzyme (AAE) consensus motif; other site
591020008666	putative AMP binding site [chemical binding]; other site
591020008667	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
591020008668	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020008669	DNA binding site [nucleotide binding]
591020008670	domain linker motif; other site
591020008671	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
591020008672	dimerization interface (closed form) [polypeptide binding]; other site
591020008673	ligand binding site [chemical binding]; other site
591020008674	diaminopimelate decarboxylase; Provisional; Region: PRK11165
591020008675	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
591020008676	active site
591020008677	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591020008678	substrate binding site [chemical binding]; other site
591020008679	catalytic residues [active]
591020008680	dimer interface [polypeptide binding]; other site
591020008681	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
591020008682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020008683	The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456
591020008684	putative dimerization interface [polypeptide binding]; other site
591020008685	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
591020008686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008687	putative substrate translocation pore; other site
591020008688	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008689	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
591020008690	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
591020008691	NADP binding site [chemical binding]; other site
591020008692	homodimer interface [polypeptide binding]; other site
591020008693	active site
591020008694	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
591020008695	putative acyltransferase; Provisional; Region: PRK05790
591020008696	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
591020008697	dimer interface [polypeptide binding]; other site
591020008698	active site
591020008699	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591020008700	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
591020008701	Transposase; Region: HTH_Tnp_1; cl17663
591020008702	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020008703	putative transposase OrfB; Reviewed; Region: PHA02517
591020008704	HTH-like domain; Region: HTH_21; pfam13276
591020008705	Integrase core domain; Region: rve; pfam00665
591020008706	Integrase core domain; Region: rve_2; pfam13333
591020008707	Protein of unknown function (DUF1682); Region: DUF1682; pfam07946
591020008708	putative transposase OrfB; Reviewed; Region: PHA02517
591020008709	HTH-like domain; Region: HTH_21; pfam13276
591020008710	Integrase core domain; Region: rve; pfam00665
591020008711	Integrase core domain; Region: rve_3; pfam13683
591020008712	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
591020008713	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
591020008714	Int/Topo IB signature motif; other site
591020008715	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
591020008716	Peptidase family M23; Region: Peptidase_M23; pfam01551
591020008717	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
591020008718	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
591020008719	xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908
591020008720	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
591020008721	catalytic loop [active]
591020008722	iron binding site [ion binding]; other site
591020008723	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
591020008724	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
591020008725	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
591020008726	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
591020008727	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020008728	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020008729	HTH-like domain; Region: HTH_21; pfam13276
591020008730	Integrase core domain; Region: rve; pfam00665
591020008731	Integrase core domain; Region: rve_3; pfam13683
591020008732	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020008733	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020008734	xanthine permease; Region: pbuX; TIGR03173
591020008735	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
591020008736	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
591020008737	active site
591020008738	metal binding site [ion binding]; metal-binding site
591020008739	nudix motif; other site
591020008740	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
591020008741	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
591020008742	dimer interface [polypeptide binding]; other site
591020008743	putative anticodon binding site; other site
591020008744	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
591020008745	motif 1; other site
591020008746	active site
591020008747	motif 2; other site
591020008748	motif 3; other site
591020008749	peptide chain release factor 2; Provisional; Region: PRK08787
591020008750	This domain is found in peptide chain release factors; Region: PCRF; smart00937
591020008751	RF-1 domain; Region: RF-1; pfam00472
591020008752	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
591020008753	DHH family; Region: DHH; pfam01368
591020008754	DHHA1 domain; Region: DHHA1; pfam02272
591020008755	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
591020008756	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
591020008757	dimerization domain [polypeptide binding]; other site
591020008758	dimer interface [polypeptide binding]; other site
591020008759	catalytic residues [active]
591020008760	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
591020008761	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
591020008762	active site
591020008763	Int/Topo IB signature motif; other site
591020008764	flavodoxin FldB; Provisional; Region: PRK12359
591020008765	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
591020008766	hypothetical protein; Provisional; Region: PRK10878
591020008767	putative global regulator; Reviewed; Region: PRK09559
591020008768	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
591020008769	hemolysin; Provisional; Region: PRK15087
591020008770	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
591020008771	hypothetical protein; Provisional; Region: PRK04980
591020008772	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
591020008773	beta-galactosidase; Region: BGL; TIGR03356
591020008774	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
591020008775	classical (c) SDRs; Region: SDR_c; cd05233
591020008776	NAD(P) binding site [chemical binding]; other site
591020008777	active site
591020008778	glycine dehydrogenase; Provisional; Region: PRK05367
591020008779	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
591020008780	tetramer interface [polypeptide binding]; other site
591020008781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020008782	catalytic residue [active]
591020008783	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
591020008784	tetramer interface [polypeptide binding]; other site
591020008785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020008786	catalytic residue [active]
591020008787	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
591020008788	lipoyl attachment site [posttranslational modification]; other site
591020008789	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
591020008790	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
591020008791	oxidoreductase; Provisional; Region: PRK08013
591020008792	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
591020008793	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
591020008794	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
591020008795	proline aminopeptidase P II; Provisional; Region: PRK10879
591020008796	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
591020008797	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
591020008798	active site
591020008799	hypothetical protein; Reviewed; Region: PRK01736
591020008800	Z-ring-associated protein; Provisional; Region: PRK10972
591020008801	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
591020008802	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
591020008803	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
591020008804	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
591020008805	ligand binding site [chemical binding]; other site
591020008806	NAD binding site [chemical binding]; other site
591020008807	tetramer interface [polypeptide binding]; other site
591020008808	catalytic site [active]
591020008809	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
591020008810	L-serine binding site [chemical binding]; other site
591020008811	ACT domain interface; other site
591020008812	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
591020008813	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591020008814	active site
591020008815	dimer interface [polypeptide binding]; other site
591020008816	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
591020008817	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020008818	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
591020008819	putative dimerization interface [polypeptide binding]; other site
591020008820	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
591020008821	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
591020008822	active site
591020008823	substrate binding site [chemical binding]; other site
591020008824	coenzyme B12 binding site [chemical binding]; other site
591020008825	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
591020008826	B12 binding site [chemical binding]; other site
591020008827	cobalt ligand [ion binding]; other site
591020008828	membrane ATPase/protein kinase; Provisional; Region: PRK09435
591020008829	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
591020008830	Walker A; other site
591020008831	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
591020008832	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591020008833	substrate binding site [chemical binding]; other site
591020008834	oxyanion hole (OAH) forming residues; other site
591020008835	trimer interface [polypeptide binding]; other site
591020008836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020008837	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591020008838	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020008839	dimerization interface [polypeptide binding]; other site
591020008840	Uncharacterized conserved protein [Function unknown]; Region: COG2968
591020008841	oxidative stress defense protein; Provisional; Region: PRK11087
591020008842	arginine exporter protein; Provisional; Region: PRK09304
591020008843	mechanosensitive channel MscS; Provisional; Region: PRK10334
591020008844	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591020008845	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
591020008846	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
591020008847	active site
591020008848	intersubunit interface [polypeptide binding]; other site
591020008849	zinc binding site [ion binding]; other site
591020008850	Na+ binding site [ion binding]; other site
591020008851	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
591020008852	Phosphoglycerate kinase; Region: PGK; pfam00162
591020008853	substrate binding site [chemical binding]; other site
591020008854	hinge regions; other site
591020008855	ADP binding site [chemical binding]; other site
591020008856	catalytic site [active]
591020008857	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
591020008858	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
591020008859	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
591020008860	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
591020008861	trimer interface [polypeptide binding]; other site
591020008862	putative Zn binding site [ion binding]; other site
591020008863	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591020008864	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591020008865	Walker A/P-loop; other site
591020008866	ATP binding site [chemical binding]; other site
591020008867	Q-loop/lid; other site
591020008868	ABC transporter signature motif; other site
591020008869	Walker B; other site
591020008870	D-loop; other site
591020008871	H-loop/switch region; other site
591020008872	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
591020008873	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
591020008874	Walker A/P-loop; other site
591020008875	ATP binding site [chemical binding]; other site
591020008876	Q-loop/lid; other site
591020008877	ABC transporter signature motif; other site
591020008878	Walker B; other site
591020008879	D-loop; other site
591020008880	H-loop/switch region; other site
591020008881	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
591020008882	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
591020008883	active site
591020008884	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
591020008885	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022
591020008886	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
591020008887	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
591020008888	putative active site [active]
591020008889	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
591020008890	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591020008891	putative NAD(P) binding site [chemical binding]; other site
591020008892	catalytic Zn binding site [ion binding]; other site
591020008893	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020008894	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
591020008895	SPFH domain / Band 7 family; Region: Band_7; pfam01145
591020008896	transketolase; Reviewed; Region: PRK12753
591020008897	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
591020008898	TPP-binding site [chemical binding]; other site
591020008899	dimer interface [polypeptide binding]; other site
591020008900	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
591020008901	PYR/PP interface [polypeptide binding]; other site
591020008902	dimer interface [polypeptide binding]; other site
591020008903	TPP binding site [chemical binding]; other site
591020008904	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
591020008905	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
591020008906	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
591020008907	agmatinase; Region: agmatinase; TIGR01230
591020008908	oligomer interface [polypeptide binding]; other site
591020008909	putative active site [active]
591020008910	Mn binding site [ion binding]; other site
591020008911	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020008912	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
591020008913	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
591020008914	dimer interface [polypeptide binding]; other site
591020008915	active site
591020008916	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591020008917	catalytic residues [active]
591020008918	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
591020008919	Virulence promoting factor; Region: YqgB; pfam11036
591020008920	Protein of unknown function (DUF2684); Region: DUF2684; pfam10885
591020008921	S-adenosylmethionine synthetase; Validated; Region: PRK05250
591020008922	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
591020008923	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
591020008924	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
591020008925	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
591020008926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008927	putative substrate translocation pore; other site
591020008928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020008929	hypothetical protein; Provisional; Region: PRK04860
591020008930	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
591020008931	DNA-specific endonuclease I; Provisional; Region: PRK15137
591020008932	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
591020008933	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
591020008934	RNA methyltransferase, RsmE family; Region: TIGR00046
591020008935	glutathione synthetase; Provisional; Region: PRK05246
591020008936	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
591020008937	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
591020008938	hypothetical protein; Validated; Region: PRK00228
591020008939	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
591020008940	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
591020008941	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
591020008942	Walker A motif; other site
591020008943	ATP binding site [chemical binding]; other site
591020008944	Walker B motif; other site
591020008945	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
591020008946	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591020008947	catalytic residue [active]
591020008948	YGGT family; Region: YGGT; pfam02325
591020008949	YGGT family; Region: YGGT; pfam02325
591020008950	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
591020008951	active site
591020008952	dimerization interface [polypeptide binding]; other site
591020008953	HemN family oxidoreductase; Provisional; Region: PRK05660
591020008954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020008955	FeS/SAM binding site; other site
591020008956	HemN C-terminal domain; Region: HemN_C; pfam06969
591020008957	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
591020008958	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
591020008959	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
591020008960	DctM-like transporters; Region: DctM; pfam06808
591020008961	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
591020008962	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
591020008963	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
591020008964	homodimer interface [polypeptide binding]; other site
591020008965	active site
591020008966	hypothetical protein; Provisional; Region: PRK10626
591020008967	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
591020008968	hypothetical protein; Provisional; Region: PRK11702
591020008969	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
591020008970	adenine DNA glycosylase; Provisional; Region: PRK10880
591020008971	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
591020008972	minor groove reading motif; other site
591020008973	helix-hairpin-helix signature motif; other site
591020008974	substrate binding pocket [chemical binding]; other site
591020008975	active site
591020008976	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
591020008977	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
591020008978	DNA binding and oxoG recognition site [nucleotide binding]
591020008979	oxidative damage protection protein; Provisional; Region: PRK05408
591020008980	murein transglycosylase C; Provisional; Region: mltC; PRK11671
591020008981	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
591020008982	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020008983	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020008984	catalytic residue [active]
591020008985	nucleoside transporter; Region: 2A0110; TIGR00889
591020008986	ornithine decarboxylase; Provisional; Region: PRK13578
591020008987	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591020008988	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591020008989	homodimer interface [polypeptide binding]; other site
591020008990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020008991	catalytic residue [active]
591020008992	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591020008993	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
591020008994	integrase; Provisional; Region: PRK09692
591020008995	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591020008996	active site
591020008997	Int/Topo IB signature motif; other site
591020008998	Part of AAA domain; Region: AAA_19; pfam13245
591020008999	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
591020009000	AAA domain; Region: AAA_12; pfam13087
591020009001	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
591020009002	putative active site [active]
591020009003	catalytic site [active]
591020009004	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
591020009005	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
591020009006	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
591020009007	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
591020009008	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
591020009009	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
591020009010	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020009011	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591020009012	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020009013	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020009014	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
591020009015	Transposase; Region: DDE_Tnp_ISL3; pfam01610
591020009016	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
591020009017	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
591020009018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
591020009019	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
591020009020	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
591020009021	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020009022	Autotransporter beta-domain; Region: Autotransporter; pfam03797
591020009023	Integrase core domain; Region: rve; pfam00665
591020009024	Integrase core domain; Region: rve_3; cl15866
591020009025	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
591020009026	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
591020009027	putative active site [active]
591020009028	putative NTP binding site [chemical binding]; other site
591020009029	putative nucleic acid binding site [nucleotide binding]; other site
591020009030	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
591020009031	HTH-like domain; Region: HTH_21; pfam13276
591020009032	Transposase; Region: HTH_Tnp_1; cl17663
591020009033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020009034	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
591020009035	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
591020009036	Integrase core domain; Region: rve; pfam00665
591020009037	Integrase core domain; Region: rve_3; pfam13683
591020009038	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
591020009039	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020009040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020009041	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020009042	HTH-like domain; Region: HTH_21; pfam13276
591020009043	Integrase core domain; Region: rve; pfam00665
591020009044	Integrase core domain; Region: rve_3; pfam13683
591020009045	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
591020009046	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009047	Predicted GTPase [General function prediction only]; Region: COG3596
591020009048	YfjP GTPase; Region: YfjP; cd11383
591020009049	G1 box; other site
591020009050	GTP/Mg2+ binding site [chemical binding]; other site
591020009051	Switch I region; other site
591020009052	G2 box; other site
591020009053	Switch II region; other site
591020009054	G3 box; other site
591020009055	G4 box; other site
591020009056	G5 box; other site
591020009057	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
591020009058	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
591020009059	hypothetical protein; Provisional; Region: PRK09945
591020009060	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
591020009061	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
591020009062	Autotransporter beta-domain; Region: Autotransporter; smart00869
591020009063	Domain of unknown function (DUF932); Region: DUF932; pfam06067
591020009064	Antirestriction protein; Region: Antirestrict; pfam03230
591020009065	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
591020009066	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
591020009067	MPN+ (JAMM) motif; other site
591020009068	Zinc-binding site [ion binding]; other site
591020009069	Protein of unknown function (DUF987); Region: DUF987; pfam06174
591020009070	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
591020009071	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
591020009072	Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117
591020009073	Methyltransferase domain; Region: Methyltransf_27; pfam13708
591020009074	Transposase; Region: HTH_Tnp_1; cl17663
591020009075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020009076	putative transposase OrfB; Reviewed; Region: PHA02517
591020009077	HTH-like domain; Region: HTH_21; pfam13276
591020009078	Integrase core domain; Region: rve; pfam00665
591020009079	Integrase core domain; Region: rve_2; pfam13333
591020009080	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
591020009081	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
591020009082	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
591020009083	DNA binding site [nucleotide binding]
591020009084	glycolate transporter; Provisional; Region: PRK09695
591020009085	L-lactate permease; Region: Lactate_perm; cl00701
591020009086	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
591020009087	active site
591020009088	hypothetical protein; Provisional; Region: PRK09732
591020009089	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
591020009090	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020009091	DNA-binding site [nucleotide binding]; DNA binding site
591020009092	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591020009093	acyl-CoA synthetase; Validated; Region: PRK09192
591020009094	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
591020009095	acyl-activating enzyme (AAE) consensus motif; other site
591020009096	active site
591020009097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
591020009098	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
591020009099	NAD(P) binding site [chemical binding]; other site
591020009100	active site
591020009101	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
591020009102	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591020009103	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591020009104	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591020009105	catalytic residue [active]
591020009106	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
591020009107	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591020009108	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591020009109	Predicted permeases [General function prediction only]; Region: COG0795
591020009110	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
591020009111	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
591020009112	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
591020009113	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
591020009114	thymidylate kinase; Validated; Region: tmk; PRK00698
591020009115	active site
591020009116	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
591020009117	thymidylate kinase; Region: DTMP_kinase; TIGR00041
591020009118	TMP-binding site; other site
591020009119	ATP-binding site [chemical binding]; other site
591020009120	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
591020009121	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591020009122	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591020009123	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
591020009124	CHAP domain; Region: CHAP; pfam05257
591020009125	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
591020009126	putative S-transferase; Provisional; Region: PRK11752
591020009127	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
591020009128	C-terminal domain interface [polypeptide binding]; other site
591020009129	GSH binding site (G-site) [chemical binding]; other site
591020009130	dimer interface [polypeptide binding]; other site
591020009131	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
591020009132	dimer interface [polypeptide binding]; other site
591020009133	N-terminal domain interface [polypeptide binding]; other site
591020009134	active site
591020009135	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
591020009136	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
591020009137	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
591020009138	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
591020009139	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
591020009140	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
591020009141	putative substrate-binding site; other site
591020009142	nickel binding site [ion binding]; other site
591020009143	hydrogenase 2 large subunit; Provisional; Region: PRK10467
591020009144	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
591020009145	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
591020009146	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
591020009147	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
591020009148	4Fe-4S binding domain; Region: Fer4_6; pfam12837
591020009149	hydrogenase 2 small subunit; Provisional; Region: PRK10468
591020009150	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
591020009151	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
591020009152	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
591020009153	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
591020009154	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591020009155	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020009156	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020009157	active site
591020009158	catalytic tetrad [active]
591020009159	hypothetical protein; Provisional; Region: PRK05208
591020009160	oxidoreductase; Provisional; Region: PRK07985
591020009161	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
591020009162	NAD binding site [chemical binding]; other site
591020009163	metal binding site [ion binding]; metal-binding site
591020009164	active site
591020009165	biopolymer transport protein ExbD; Provisional; Region: PRK11267
591020009166	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
591020009167	biopolymer transport protein ExbB; Provisional; Region: PRK10414
591020009168	cystathionine beta-lyase; Provisional; Region: PRK08114
591020009169	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
591020009170	homodimer interface [polypeptide binding]; other site
591020009171	substrate-cofactor binding pocket; other site
591020009172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020009173	catalytic residue [active]
591020009174	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591020009175	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
591020009176	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
591020009177	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
591020009178	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020009179	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020009180	potential protein location (hypothetical protein) that overlaps protein (putative ARAC-type regulatory protein)
591020009181	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
591020009182	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
591020009183	dimer interface [polypeptide binding]; other site
591020009184	active site
591020009185	metal binding site [ion binding]; metal-binding site
591020009186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
591020009187	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
591020009188	active site
591020009189	catalytic tetrad [active]
591020009190	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
591020009191	putative outer membrane lipoprotein; Provisional; Region: PRK09973
591020009192	hypothetical protein; Provisional; Region: PRK01254
591020009193	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
591020009194	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
591020009195	FtsI repressor; Provisional; Region: PRK10883
591020009196	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
591020009197	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
591020009198	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
591020009199	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
591020009200	putative acyl-acceptor binding pocket; other site
591020009201	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
591020009202	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
591020009203	CAP-like domain; other site
591020009204	active site
591020009205	primary dimer interface [polypeptide binding]; other site
591020009206	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
591020009207	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
591020009208	TIGR00156 family protein; Region: TIGR00156
591020009209	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
591020009210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020009211	active site
591020009212	phosphorylation site [posttranslational modification]
591020009213	intermolecular recognition site; other site
591020009214	dimerization interface [polypeptide binding]; other site
591020009215	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020009216	DNA binding site [nucleotide binding]
591020009217	sensor protein QseC; Provisional; Region: PRK10337
591020009218	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020009219	dimer interface [polypeptide binding]; other site
591020009220	phosphorylation site [posttranslational modification]
591020009221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020009222	ATP binding site [chemical binding]; other site
591020009223	G-X-G motif; other site
591020009224	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
591020009225	Uncharacterized conserved protein [Function unknown]; Region: COG1359
591020009226	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
591020009227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020009228	ATP binding site [chemical binding]; other site
591020009229	Mg2+ binding site [ion binding]; other site
591020009230	G-X-G motif; other site
591020009231	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
591020009232	anchoring element; other site
591020009233	dimer interface [polypeptide binding]; other site
591020009234	ATP binding site [chemical binding]; other site
591020009235	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
591020009236	active site
591020009237	metal binding site [ion binding]; metal-binding site
591020009238	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
591020009239	esterase YqiA; Provisional; Region: PRK11071
591020009240	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
591020009241	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
591020009242	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
591020009243	active site
591020009244	metal binding site [ion binding]; metal-binding site
591020009245	hexamer interface [polypeptide binding]; other site
591020009246	putative dehydrogenase; Provisional; Region: PRK11039
591020009247	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
591020009248	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
591020009249	dimer interface [polypeptide binding]; other site
591020009250	ADP-ribose binding site [chemical binding]; other site
591020009251	active site
591020009252	nudix motif; other site
591020009253	metal binding site [ion binding]; metal-binding site
591020009254	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
591020009255	hypothetical protein; Provisional; Region: PRK11653
591020009256	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
591020009257	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
591020009258	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
591020009259	putative active site [active]
591020009260	metal binding site [ion binding]; metal-binding site
591020009261	zinc transporter ZupT; Provisional; Region: PRK04201
591020009262	ZIP Zinc transporter; Region: Zip; pfam02535
591020009263	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
591020009264	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
591020009265	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
591020009266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
591020009267	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020009268	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020009269	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020009270	HTH-like domain; Region: HTH_21; pfam13276
591020009271	Integrase core domain; Region: rve; pfam00665
591020009272	Integrase core domain; Region: rve_3; pfam13683
591020009273	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
591020009274	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
591020009276	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
591020009277	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
591020009278	putative ribose interaction site [chemical binding]; other site
591020009279	putative ADP binding site [chemical binding]; other site
591020009280	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
591020009281	active site
591020009282	nucleotide binding site [chemical binding]; other site
591020009283	HIGH motif; other site
591020009284	KMSKS motif; other site
591020009285	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
591020009286	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
591020009287	metal binding triad; other site
591020009288	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
591020009289	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
591020009290	metal binding triad; other site
591020009291	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
591020009292	Uncharacterized conserved protein [Function unknown]; Region: COG3025
591020009293	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
591020009294	putative active site [active]
591020009295	putative metal binding residues [ion binding]; other site
591020009296	signature motif; other site
591020009297	putative triphosphate binding site [ion binding]; other site
591020009298	CHAD domain; Region: CHAD; pfam05235
591020009299	SH3 domain-containing protein; Provisional; Region: PRK10884
591020009300	Bacterial SH3 domain homologues; Region: SH3b; smart00287
591020009301	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
591020009302	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
591020009303	active site
591020009304	NTP binding site [chemical binding]; other site
591020009305	metal binding triad [ion binding]; metal-binding site
591020009306	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
591020009307	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591020009308	Zn2+ binding site [ion binding]; other site
591020009309	Mg2+ binding site [ion binding]; other site
591020009310	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
591020009311	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
591020009312	homooctamer interface [polypeptide binding]; other site
591020009313	active site
591020009314	transcriptional activator TtdR; Provisional; Region: PRK09801
591020009315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020009316	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
591020009317	putative effector binding pocket; other site
591020009318	putative dimerization interface [polypeptide binding]; other site
591020009319	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
591020009320	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
591020009321	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
591020009322	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
591020009323	transmembrane helices; other site
591020009324	UGMP family protein; Validated; Region: PRK09604
591020009325	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
591020009326	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
591020009327	DNA primase; Validated; Region: dnaG; PRK05667
591020009328	CHC2 zinc finger; Region: zf-CHC2; pfam01807
591020009329	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
591020009330	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
591020009331	active site
591020009332	metal binding site [ion binding]; metal-binding site
591020009333	interdomain interaction site; other site
591020009334	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
591020009335	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
591020009336	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
591020009337	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
591020009338	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
591020009339	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
591020009340	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591020009341	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
591020009342	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591020009343	DNA binding residues [nucleotide binding]
591020009344	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020009345	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020009346	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020009347	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
591020009348	active site
591020009349	Predicted transcriptional regulators [Transcription]; Region: COG1695
591020009350	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
591020009351	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
591020009352	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591020009353	inhibitor-cofactor binding pocket; inhibition site
591020009354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020009355	catalytic residue [active]
591020009356	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
591020009357	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020009358	DNA binding site [nucleotide binding]
591020009359	domain linker motif; other site
591020009360	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
591020009361	putative dimerization interface [polypeptide binding]; other site
591020009362	putative ligand binding site [chemical binding]; other site
591020009363	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
591020009364	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
591020009365	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
591020009366	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
591020009367	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
591020009368	cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202
591020009369	inner membrane transporter YjeM; Provisional; Region: PRK15238
591020009370	alpha-glucosidase; Provisional; Region: PRK10137
591020009371	Protein of unknown function, DUF608; Region: DUF608; pfam04685
591020009372	Trehalase; Region: Trehalase; cl17346
591020009373	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
591020009374	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
591020009375	active site
591020009376	FMN binding site [chemical binding]; other site
591020009377	2,4-decadienoyl-CoA binding site; other site
591020009378	catalytic residue [active]
591020009379	4Fe-4S cluster binding site [ion binding]; other site
591020009380	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
591020009381	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020009382	non-specific DNA binding site [nucleotide binding]; other site
591020009383	salt bridge; other site
591020009384	sequence-specific DNA binding site [nucleotide binding]; other site
591020009385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
591020009386	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
591020009387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020009388	S-adenosylmethionine binding site [chemical binding]; other site
591020009389	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
591020009390	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
591020009391	putative active site [active]
591020009392	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
591020009393	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591020009394	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
591020009395	serine/threonine transporter SstT; Provisional; Region: PRK13628
591020009396	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591020009397	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
591020009398	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
591020009399	galactarate dehydratase; Region: galactar-dH20; TIGR03248
591020009400	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
591020009401	Glucuronate isomerase; Region: UxaC; pfam02614
591020009402	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
591020009403	D-galactonate transporter; Region: 2A0114; TIGR00893
591020009404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020009405	putative substrate translocation pore; other site
591020009406	CblD like pilus biogenesis initiator; Region: CblD; cl06460
591020009407	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020009408	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009409	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
591020009410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020009411	DNA-binding site [nucleotide binding]; DNA binding site
591020009412	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591020009413	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
591020009414	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
591020009415	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
591020009416	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
591020009417	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
591020009418	Predicted membrane protein [Function unknown]; Region: COG5393
591020009419	YqjK-like protein; Region: YqjK; pfam13997
591020009420	Predicted membrane protein [Function unknown]; Region: COG2259
591020009421	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
591020009422	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
591020009423	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
591020009424	putative dimer interface [polypeptide binding]; other site
591020009425	N-terminal domain interface [polypeptide binding]; other site
591020009426	putative substrate binding pocket (H-site) [chemical binding]; other site
591020009427	Predicted membrane protein [Function unknown]; Region: COG3152
591020009428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020009429	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
591020009430	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
591020009431	dimerization interface [polypeptide binding]; other site
591020009432	Pirin-related protein [General function prediction only]; Region: COG1741
591020009433	Pirin; Region: Pirin; pfam02678
591020009434	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
591020009435	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591020009436	serine transporter; Region: stp; TIGR00814
591020009437	L-serine dehydratase TdcG; Provisional; Region: PRK15040
591020009438	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
591020009439	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
591020009440	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
591020009441	homotrimer interaction site [polypeptide binding]; other site
591020009442	putative active site [active]
591020009443	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
591020009444	Pyruvate formate lyase 1; Region: PFL1; cd01678
591020009445	coenzyme A binding site [chemical binding]; other site
591020009446	active site
591020009447	catalytic residues [active]
591020009448	glycine loop; other site
591020009449	propionate/acetate kinase; Provisional; Region: PRK12379
591020009450	Acetokinase family; Region: Acetate_kinase; cl17229
591020009451	threonine/serine transporter TdcC; Provisional; Region: PRK13629
591020009452	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591020009453	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
591020009454	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
591020009455	tetramer interface [polypeptide binding]; other site
591020009456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020009457	catalytic residue [active]
591020009458	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
591020009459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020009460	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
591020009461	putative substrate binding pocket [chemical binding]; other site
591020009462	putative dimerization interface [polypeptide binding]; other site
591020009463	DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424
591020009464	Protein of unknown function (DUF3521); Region: DUF3521; pfam12035
591020009465	glycerate kinase I; Provisional; Region: PRK10342
591020009466	2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505
591020009467	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591020009468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020009469	D-galactonate transporter; Region: 2A0114; TIGR00893
591020009470	putative substrate translocation pore; other site
591020009471	galactarate dehydratase; Region: galactar-dH20; TIGR03248
591020009472	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
591020009473	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
591020009474	DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802
591020009475	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591020009476	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020009477	tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458
591020009478	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591020009479	active site
591020009480	phosphorylation site [posttranslational modification]
591020009481	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
591020009482	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
591020009483	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591020009484	active pocket/dimerization site; other site
591020009485	active site
591020009486	phosphorylation site [posttranslational modification]
591020009487	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
591020009488	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
591020009489	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009490	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
591020009491	PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757
591020009492	PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855
591020009493	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
591020009494	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
591020009495	active site
591020009496	trimer interface [polypeptide binding]; other site
591020009497	allosteric site; other site
591020009498	active site lid [active]
591020009499	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009500	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591020009501	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
591020009502	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591020009503	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591020009504	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020009505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020009506	Fimbrial protein; Region: Fimbrial; pfam00419
591020009507	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
591020009508	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
591020009509	putative SAM binding site [chemical binding]; other site
591020009510	putative homodimer interface [polypeptide binding]; other site
591020009511	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
591020009512	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
591020009513	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
591020009514	putative ligand binding site [chemical binding]; other site
591020009515	TIGR00252 family protein; Region: TIGR00252
591020009516	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
591020009517	dimer interface [polypeptide binding]; other site
591020009518	active site
591020009519	outer membrane lipoprotein; Provisional; Region: PRK11023
591020009520	BON domain; Region: BON; pfam04972
591020009521	BON domain; Region: BON; pfam04972
591020009522	Predicted permease; Region: DUF318; pfam03773
591020009523	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
591020009524	NADH(P)-binding; Region: NAD_binding_10; pfam13460
591020009525	NAD binding site [chemical binding]; other site
591020009526	active site
591020009527	intracellular protease, PfpI family; Region: PfpI; TIGR01382
591020009528	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
591020009529	proposed catalytic triad [active]
591020009530	conserved cys residue [active]
591020009531	hypothetical protein; Provisional; Region: PRK03467
591020009532	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
591020009533	GIY-YIG motif/motif A; other site
591020009534	putative active site [active]
591020009535	putative metal binding site [ion binding]; other site
591020009536	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591020009537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020009538	Coenzyme A binding pocket [chemical binding]; other site
591020009539	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
591020009540	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
591020009541	Peptidase family U32; Region: Peptidase_U32; pfam01136
591020009542	putative protease; Provisional; Region: PRK15447
591020009543	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
591020009544	hypothetical protein; Provisional; Region: PRK10508
591020009545	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
591020009546	tryptophan permease; Provisional; Region: PRK10483
591020009547	aromatic amino acid transport protein; Region: araaP; TIGR00837
591020009548	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
591020009549	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591020009550	ATP binding site [chemical binding]; other site
591020009551	Mg++ binding site [ion binding]; other site
591020009552	motif III; other site
591020009553	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020009554	nucleotide binding region [chemical binding]; other site
591020009555	ATP-binding site [chemical binding]; other site
591020009556	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
591020009557	putative RNA binding site [nucleotide binding]; other site
591020009558	lipoprotein NlpI; Provisional; Region: PRK11189
591020009559	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591020009560	binding surface
591020009561	TPR motif; other site
591020009562	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
591020009563	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
591020009564	RNase E interface [polypeptide binding]; other site
591020009565	trimer interface [polypeptide binding]; other site
591020009566	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
591020009567	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
591020009568	RNase E interface [polypeptide binding]; other site
591020009569	trimer interface [polypeptide binding]; other site
591020009570	active site
591020009571	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
591020009572	putative nucleic acid binding region [nucleotide binding]; other site
591020009573	G-X-X-G motif; other site
591020009574	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
591020009575	RNA binding site [nucleotide binding]; other site
591020009576	domain interface; other site
591020009577	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
591020009578	16S/18S rRNA binding site [nucleotide binding]; other site
591020009579	S13e-L30e interaction site [polypeptide binding]; other site
591020009580	25S rRNA binding site [nucleotide binding]; other site
591020009581	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
591020009582	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
591020009583	RNA binding site [nucleotide binding]; other site
591020009584	active site
591020009585	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
591020009586	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
591020009587	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
591020009588	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
591020009589	translation initiation factor IF-2; Region: IF-2; TIGR00487
591020009590	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
591020009591	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
591020009592	G1 box; other site
591020009593	putative GEF interaction site [polypeptide binding]; other site
591020009594	GTP/Mg2+ binding site [chemical binding]; other site
591020009595	Switch I region; other site
591020009596	G2 box; other site
591020009597	G3 box; other site
591020009598	Switch II region; other site
591020009599	G4 box; other site
591020009600	G5 box; other site
591020009601	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
591020009602	Translation-initiation factor 2; Region: IF-2; pfam11987
591020009603	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
591020009604	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
591020009605	NusA N-terminal domain; Region: NusA_N; pfam08529
591020009606	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
591020009607	RNA binding site [nucleotide binding]; other site
591020009608	homodimer interface [polypeptide binding]; other site
591020009609	NusA-like KH domain; Region: KH_5; pfam13184
591020009610	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
591020009611	G-X-X-G motif; other site
591020009612	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
591020009613	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
591020009614	ribosome maturation protein RimP; Reviewed; Region: PRK00092
591020009615	Sm and related proteins; Region: Sm_like; cl00259
591020009616	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
591020009617	putative oligomer interface [polypeptide binding]; other site
591020009618	putative RNA binding site [nucleotide binding]; other site
591020009619	argininosuccinate synthase; Validated; Region: PRK05370
591020009620	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
591020009621	Sulfatase; Region: Sulfatase; pfam00884
591020009622	Preprotein translocase SecG subunit; Region: SecG; pfam03840
591020009623	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
591020009624	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
591020009625	active site
591020009626	substrate binding site [chemical binding]; other site
591020009627	metal binding site [ion binding]; metal-binding site
591020009628	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
591020009629	dihydropteroate synthase; Region: DHPS; TIGR01496
591020009630	substrate binding pocket [chemical binding]; other site
591020009631	dimer interface [polypeptide binding]; other site
591020009632	inhibitor binding site; inhibition site
591020009633	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
591020009634	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020009635	Walker A motif; other site
591020009636	ATP binding site [chemical binding]; other site
591020009637	Walker B motif; other site
591020009638	arginine finger; other site
591020009639	Peptidase family M41; Region: Peptidase_M41; pfam01434
591020009640	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
591020009641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020009642	S-adenosylmethionine binding site [chemical binding]; other site
591020009643	RNA-binding protein YhbY; Provisional; Region: PRK10343
591020009644	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
591020009645	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
591020009646	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
591020009647	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
591020009648	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
591020009649	GTPase CgtA; Reviewed; Region: obgE; PRK12298
591020009650	GTP1/OBG; Region: GTP1_OBG; pfam01018
591020009651	Obg GTPase; Region: Obg; cd01898
591020009652	G1 box; other site
591020009653	GTP/Mg2+ binding site [chemical binding]; other site
591020009654	Switch I region; other site
591020009655	G2 box; other site
591020009656	G3 box; other site
591020009657	Switch II region; other site
591020009658	G4 box; other site
591020009659	G5 box; other site
591020009660	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
591020009661	EamA-like transporter family; Region: EamA; pfam00892
591020009662	EamA-like transporter family; Region: EamA; pfam00892
591020009663	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
591020009664	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
591020009665	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
591020009666	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
591020009667	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
591020009668	substrate binding pocket [chemical binding]; other site
591020009669	chain length determination region; other site
591020009670	substrate-Mg2+ binding site; other site
591020009671	catalytic residues [active]
591020009672	aspartate-rich region 1; other site
591020009673	active site lid residues [active]
591020009674	aspartate-rich region 2; other site
591020009675	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
591020009676	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
591020009677	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
591020009678	hinge; other site
591020009679	active site
591020009680	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
591020009681	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
591020009682	anti sigma factor interaction site; other site
591020009683	regulatory phosphorylation site [posttranslational modification]; other site
591020009684	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
591020009685	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
591020009686	mce related protein; Region: MCE; pfam02470
591020009687	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
591020009688	conserved hypothetical integral membrane protein; Region: TIGR00056
591020009689	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
591020009690	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
591020009691	Walker A/P-loop; other site
591020009692	ATP binding site [chemical binding]; other site
591020009693	Q-loop/lid; other site
591020009694	ABC transporter signature motif; other site
591020009695	Walker B; other site
591020009696	D-loop; other site
591020009697	H-loop/switch region; other site
591020009698	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
591020009699	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
591020009700	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
591020009701	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
591020009702	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
591020009703	putative active site [active]
591020009704	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
591020009705	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
591020009706	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
591020009707	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
591020009708	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
591020009709	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
591020009710	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
591020009711	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
591020009712	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
591020009713	Walker A/P-loop; other site
591020009714	ATP binding site [chemical binding]; other site
591020009715	Q-loop/lid; other site
591020009716	ABC transporter signature motif; other site
591020009717	Walker B; other site
591020009718	D-loop; other site
591020009719	H-loop/switch region; other site
591020009720	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
591020009721	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
591020009722	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
591020009723	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
591020009724	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
591020009725	30S subunit binding site; other site
591020009726	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020009727	active site
591020009728	phosphorylation site [posttranslational modification]
591020009729	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
591020009730	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
591020009731	dimerization domain swap beta strand [polypeptide binding]; other site
591020009732	regulatory protein interface [polypeptide binding]; other site
591020009733	active site
591020009734	regulatory phosphorylation site [posttranslational modification]; other site
591020009735	hypothetical protein; Provisional; Region: PRK10345
591020009736	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
591020009737	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
591020009738	conserved cys residue [active]
591020009739	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
591020009740	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591020009741	putative active site [active]
591020009742	heme pocket [chemical binding]; other site
591020009743	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020009744	dimer interface [polypeptide binding]; other site
591020009745	phosphorylation site [posttranslational modification]
591020009746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020009747	ATP binding site [chemical binding]; other site
591020009748	Mg2+ binding site [ion binding]; other site
591020009749	G-X-G motif; other site
591020009750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020009751	active site
591020009752	phosphorylation site [posttranslational modification]
591020009753	intermolecular recognition site; other site
591020009754	dimerization interface [polypeptide binding]; other site
591020009755	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
591020009756	putative binding surface; other site
591020009757	active site
591020009758	radical SAM protein, TIGR01212 family; Region: TIGR01212
591020009759	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020009760	FeS/SAM binding site; other site
591020009761	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
591020009762	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
591020009763	active site
591020009764	dimer interface [polypeptide binding]; other site
591020009765	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
591020009766	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
591020009767	active site
591020009768	FMN binding site [chemical binding]; other site
591020009769	substrate binding site [chemical binding]; other site
591020009770	3Fe-4S cluster binding site [ion binding]; other site
591020009771	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
591020009772	domain interface; other site
591020009773	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
591020009774	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591020009775	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020009776	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
591020009777	putative transposase OrfB; Reviewed; Region: PHA02517
591020009778	Integrase core domain; Region: rve; pfam00665
591020009779	Integrase core domain; Region: rve_3; pfam13683
591020009780	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
591020009781	N-acetylmannosamine kinase; Provisional; Region: PRK05082
591020009782	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
591020009783	nucleotide binding site [chemical binding]; other site
591020009784	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
591020009785	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
591020009786	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
591020009787	putative active site cavity [active]
591020009788	putative sialic acid transporter; Provisional; Region: PRK03893
591020009789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020009790	putative substrate translocation pore; other site
591020009791	N-acetylneuraminate lyase; Region: nanA; TIGR00683
591020009792	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
591020009793	inhibitor site; inhibition site
591020009794	active site
591020009795	dimer interface [polypeptide binding]; other site
591020009796	catalytic residue [active]
591020009797	transcriptional regulator NanR; Provisional; Region: PRK03837
591020009798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020009799	DNA-binding site [nucleotide binding]; DNA binding site
591020009800	FCD domain; Region: FCD; pfam07729
591020009801	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009802	putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804
591020009803	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
591020009804	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
591020009805	stringent starvation protein A; Provisional; Region: sspA; PRK09481
591020009806	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
591020009807	C-terminal domain interface [polypeptide binding]; other site
591020009808	putative GSH binding site (G-site) [chemical binding]; other site
591020009809	dimer interface [polypeptide binding]; other site
591020009810	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
591020009811	dimer interface [polypeptide binding]; other site
591020009812	N-terminal domain interface [polypeptide binding]; other site
591020009813	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
591020009814	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
591020009815	23S rRNA interface [nucleotide binding]; other site
591020009816	L3 interface [polypeptide binding]; other site
591020009817	Predicted ATPase [General function prediction only]; Region: COG1485
591020009818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
591020009819	hypothetical protein; Provisional; Region: PRK11677
591020009820	serine endoprotease; Provisional; Region: PRK10898
591020009821	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
591020009822	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
591020009823	malate dehydrogenase; Provisional; Region: PRK05086
591020009824	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
591020009825	NAD binding site [chemical binding]; other site
591020009826	dimerization interface [polypeptide binding]; other site
591020009827	Substrate binding site [chemical binding]; other site
591020009828	arginine repressor; Provisional; Region: PRK05066
591020009829	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
591020009830	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
591020009831	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591020009832	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
591020009833	RNAase interaction site [polypeptide binding]; other site
591020009834	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
591020009835	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591020009836	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
591020009837	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020009838	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020009839	efflux system membrane protein; Provisional; Region: PRK11594
591020009840	transcriptional regulator; Provisional; Region: PRK10632
591020009841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020009842	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
591020009843	putative effector binding pocket; other site
591020009844	dimerization interface [polypeptide binding]; other site
591020009845	protease TldD; Provisional; Region: tldD; PRK10735
591020009846	hypothetical protein; Provisional; Region: PRK10899
591020009847	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
591020009848	ribonuclease G; Provisional; Region: PRK11712
591020009849	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
591020009850	homodimer interface [polypeptide binding]; other site
591020009851	oligonucleotide binding site [chemical binding]; other site
591020009852	Maf-like protein; Region: Maf; pfam02545
591020009853	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
591020009854	active site
591020009855	dimer interface [polypeptide binding]; other site
591020009856	rod shape-determining protein MreD; Provisional; Region: PRK11060
591020009857	rod shape-determining protein MreC; Region: mreC; TIGR00219
591020009858	rod shape-determining protein MreC; Region: MreC; pfam04085
591020009859	rod shape-determining protein MreB; Provisional; Region: PRK13927
591020009860	MreB and similar proteins; Region: MreB_like; cd10225
591020009861	nucleotide binding site [chemical binding]; other site
591020009862	Mg binding site [ion binding]; other site
591020009863	putative protofilament interaction site [polypeptide binding]; other site
591020009864	RodZ interaction site [polypeptide binding]; other site
591020009865	regulatory protein CsrD; Provisional; Region: PRK11059
591020009866	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020009867	metal binding site [ion binding]; metal-binding site
591020009868	active site
591020009869	I-site; other site
591020009870	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020009871	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
591020009872	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
591020009873	NADP binding site [chemical binding]; other site
591020009874	dimer interface [polypeptide binding]; other site
591020009875	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
591020009876	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
591020009877	carboxyltransferase (CT) interaction site; other site
591020009878	biotinylation site [posttranslational modification]; other site
591020009879	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
591020009880	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
591020009881	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
591020009882	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
591020009883	hypothetical protein; Provisional; Region: PRK10633
591020009884	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
591020009885	Na binding site [ion binding]; other site
591020009886	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
591020009887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
591020009888	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
591020009889	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
591020009890	FMN binding site [chemical binding]; other site
591020009891	active site
591020009892	catalytic residues [active]
591020009893	substrate binding site [chemical binding]; other site
591020009894	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
591020009895	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
591020009896	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
591020009897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020009898	DNA methylase; Region: N6_N4_Mtase; pfam01555
591020009899	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
591020009900	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009901	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
591020009902	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020009903	substrate binding pocket [chemical binding]; other site
591020009904	membrane-bound complex binding site; other site
591020009905	hinge residues; other site
591020009906	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020009907	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
591020009908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020009909	dimer interface [polypeptide binding]; other site
591020009910	conserved gate region; other site
591020009911	putative PBP binding loops; other site
591020009912	ABC-ATPase subunit interface; other site
591020009913	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
591020009914	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
591020009915	Walker A/P-loop; other site
591020009916	ATP binding site [chemical binding]; other site
591020009917	Q-loop/lid; other site
591020009918	ABC transporter signature motif; other site
591020009919	Walker B; other site
591020009920	D-loop; other site
591020009921	H-loop/switch region; other site
591020009922	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
591020009923	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
591020009924	trimer interface [polypeptide binding]; other site
591020009925	putative metal binding site [ion binding]; other site
591020009926	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
591020009927	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
591020009928	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
591020009929	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
591020009930	shikimate binding site; other site
591020009931	NAD(P) binding site [chemical binding]; other site
591020009932	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
591020009933	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591020009934	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
591020009935	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591020009936	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
591020009937	hypothetical protein; Validated; Region: PRK03430
591020009938	hypothetical protein; Provisional; Region: PRK10736
591020009939	DNA protecting protein DprA; Region: dprA; TIGR00732
591020009940	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
591020009941	active site
591020009942	catalytic residues [active]
591020009943	metal binding site [ion binding]; metal-binding site
591020009944	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
591020009945	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
591020009946	putative active site [active]
591020009947	substrate binding site [chemical binding]; other site
591020009948	putative cosubstrate binding site; other site
591020009949	catalytic site [active]
591020009950	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
591020009951	substrate binding site [chemical binding]; other site
591020009952	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
591020009953	putative RNA binding site [nucleotide binding]; other site
591020009954	16S rRNA methyltransferase B; Provisional; Region: PRK10901
591020009955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020009956	S-adenosylmethionine binding site [chemical binding]; other site
591020009957	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
591020009958	TrkA-N domain; Region: TrkA_N; pfam02254
591020009959	TrkA-C domain; Region: TrkA_C; pfam02080
591020009960	TrkA-N domain; Region: TrkA_N; pfam02254
591020009961	TrkA-C domain; Region: TrkA_C; pfam02080
591020009962	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
591020009963	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
591020009964	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
591020009965	alphaNTD homodimer interface [polypeptide binding]; other site
591020009966	alphaNTD - beta interaction site [polypeptide binding]; other site
591020009967	alphaNTD - beta' interaction site [polypeptide binding]; other site
591020009968	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
591020009969	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
591020009970	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
591020009971	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020009972	RNA binding surface [nucleotide binding]; other site
591020009973	30S ribosomal protein S11; Validated; Region: PRK05309
591020009974	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
591020009975	30S ribosomal protein S13; Region: bact_S13; TIGR03631
591020009976	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
591020009977	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
591020009978	SecY translocase; Region: SecY; pfam00344
591020009979	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
591020009980	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
591020009981	23S rRNA binding site [nucleotide binding]; other site
591020009982	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
591020009983	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
591020009984	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
591020009985	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
591020009986	23S rRNA interface [nucleotide binding]; other site
591020009987	5S rRNA interface [nucleotide binding]; other site
591020009988	L27 interface [polypeptide binding]; other site
591020009989	L5 interface [polypeptide binding]; other site
591020009990	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
591020009991	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
591020009992	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
591020009993	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
591020009994	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
591020009995	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
591020009996	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
591020009997	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
591020009998	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
591020009999	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
591020010000	RNA binding site [nucleotide binding]; other site
591020010001	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
591020010002	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
591020010003	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
591020010004	23S rRNA interface [nucleotide binding]; other site
591020010005	putative translocon interaction site; other site
591020010006	signal recognition particle (SRP54) interaction site; other site
591020010007	L23 interface [polypeptide binding]; other site
591020010008	trigger factor interaction site; other site
591020010009	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
591020010010	23S rRNA interface [nucleotide binding]; other site
591020010011	5S rRNA interface [nucleotide binding]; other site
591020010012	putative antibiotic binding site [chemical binding]; other site
591020010013	L25 interface [polypeptide binding]; other site
591020010014	L27 interface [polypeptide binding]; other site
591020010015	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
591020010016	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
591020010017	G-X-X-G motif; other site
591020010018	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
591020010019	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
591020010020	protein-rRNA interface [nucleotide binding]; other site
591020010021	putative translocon binding site; other site
591020010022	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
591020010023	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
591020010024	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
591020010025	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
591020010026	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
591020010027	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
591020010028	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
591020010029	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
591020010030	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
591020010031	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
591020010032	heme binding site [chemical binding]; other site
591020010033	ferroxidase pore; other site
591020010034	ferroxidase diiron center [ion binding]; other site
591020010035	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
591020010036	elongation factor Tu; Reviewed; Region: PRK00049
591020010037	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
591020010038	G1 box; other site
591020010039	GEF interaction site [polypeptide binding]; other site
591020010040	GTP/Mg2+ binding site [chemical binding]; other site
591020010041	Switch I region; other site
591020010042	G2 box; other site
591020010043	G3 box; other site
591020010044	Switch II region; other site
591020010045	G4 box; other site
591020010046	G5 box; other site
591020010047	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
591020010048	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
591020010049	Antibiotic Binding Site [chemical binding]; other site
591020010050	elongation factor G; Reviewed; Region: PRK00007
591020010051	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
591020010052	G1 box; other site
591020010053	putative GEF interaction site [polypeptide binding]; other site
591020010054	GTP/Mg2+ binding site [chemical binding]; other site
591020010055	Switch I region; other site
591020010056	G2 box; other site
591020010057	G3 box; other site
591020010058	Switch II region; other site
591020010059	G4 box; other site
591020010060	G5 box; other site
591020010061	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
591020010062	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
591020010063	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
591020010064	30S ribosomal protein S7; Validated; Region: PRK05302
591020010065	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
591020010066	S17 interaction site [polypeptide binding]; other site
591020010067	S8 interaction site; other site
591020010068	16S rRNA interaction site [nucleotide binding]; other site
591020010069	streptomycin interaction site [chemical binding]; other site
591020010070	23S rRNA interaction site [nucleotide binding]; other site
591020010071	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
591020010072	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
591020010073	sulfur relay protein TusC; Validated; Region: PRK00211
591020010074	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
591020010075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
591020010076	YheO-like PAS domain; Region: PAS_6; pfam08348
591020010077	HTH domain; Region: HTH_22; pfam13309
591020010078	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
591020010079	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
591020010080	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591020010081	phi X174 lysis protein; Provisional; Region: PRK02793
591020010082	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
591020010083	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
591020010084	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
591020010085	TrkA-N domain; Region: TrkA_N; pfam02254
591020010086	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
591020010087	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
591020010088	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020010089	Walker A/P-loop; other site
591020010090	ATP binding site [chemical binding]; other site
591020010091	Q-loop/lid; other site
591020010092	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591020010093	ABC transporter; Region: ABC_tran_2; pfam12848
591020010094	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591020010095	putative hydrolase; Provisional; Region: PRK10985
591020010096	hypothetical protein; Provisional; Region: PRK04966
591020010097	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
591020010098	active site
591020010099	hypothetical protein; Provisional; Region: PRK10738
591020010100	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
591020010101	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
591020010102	ligand binding site [chemical binding]; other site
591020010103	flexible hinge region; other site
591020010104	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
591020010105	putative switch regulator; other site
591020010106	non-specific DNA interactions [nucleotide binding]; other site
591020010107	DNA binding site [nucleotide binding]
591020010108	sequence specific DNA binding site [nucleotide binding]; other site
591020010109	putative cAMP binding site [chemical binding]; other site
591020010110	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
591020010111	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
591020010112	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591020010113	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
591020010114	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
591020010115	inhibitor-cofactor binding pocket; inhibition site
591020010116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020010117	catalytic residue [active]
591020010118	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
591020010119	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
591020010120	glutamine binding [chemical binding]; other site
591020010121	catalytic triad [active]
591020010122	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
591020010123	cell filamentation protein Fic; Provisional; Region: PRK10347
591020010124	hypothetical protein; Provisional; Region: PRK10204
591020010125	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
591020010126	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
591020010127	substrate binding site [chemical binding]; other site
591020010128	putative transporter; Provisional; Region: PRK03699
591020010129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020010130	putative substrate translocation pore; other site
591020010131	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
591020010132	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020010133	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
591020010134	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
591020010135	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
591020010136	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
591020010137	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
591020010138	nitrite transporter NirC; Provisional; Region: PRK11562
591020010139	siroheme synthase; Provisional; Region: cysG; PRK10637
591020010140	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
591020010141	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
591020010142	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
591020010143	active site
591020010144	SAM binding site [chemical binding]; other site
591020010145	homodimer interface [polypeptide binding]; other site
591020010146	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
591020010147	fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382
591020010148	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
591020010149	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
591020010150	dimer interface [polypeptide binding]; other site
591020010151	active site
591020010152	fructoselysine 3-epimerase; Provisional; Region: PRK09856
591020010153	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
591020010154	DNA interaction; other site
591020010155	Metal-binding active site; metal-binding site
591020010156	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
591020010157	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020010158	substrate binding site [chemical binding]; other site
591020010159	ATP binding site [chemical binding]; other site
591020010160	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
591020010161	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020010162	DNA-binding site [nucleotide binding]; DNA binding site
591020010163	UTRA domain; Region: UTRA; pfam07702
591020010164	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
591020010165	Protein of unknown function; Region: YhfT; pfam10797
591020010166	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
591020010167	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
591020010168	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
591020010169	active site
591020010170	substrate binding pocket [chemical binding]; other site
591020010171	homodimer interaction site [polypeptide binding]; other site
591020010172	putative mutase; Provisional; Region: PRK12383
591020010173	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015
591020010174	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
591020010175	dimer interface [polypeptide binding]; other site
591020010176	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
591020010177	active site
591020010178	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591020010179	substrate binding site [chemical binding]; other site
591020010180	catalytic residue [active]
591020010181	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
591020010182	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
591020010183	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
591020010184	active site
591020010185	HIGH motif; other site
591020010186	dimer interface [polypeptide binding]; other site
591020010187	KMSKS motif; other site
591020010188	phosphoglycolate phosphatase; Provisional; Region: PRK13222
591020010189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020010190	motif II; other site
591020010191	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
591020010192	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
591020010193	substrate binding site [chemical binding]; other site
591020010194	hexamer interface [polypeptide binding]; other site
591020010195	metal binding site [ion binding]; metal-binding site
591020010196	DNA adenine methylase; Provisional; Region: PRK10904
591020010197	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
591020010198	cell division protein DamX; Validated; Region: PRK10905
591020010199	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
591020010200	active site
591020010201	dimer interface [polypeptide binding]; other site
591020010202	metal binding site [ion binding]; metal-binding site
591020010203	shikimate kinase; Reviewed; Region: aroK; PRK00131
591020010204	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
591020010205	ADP binding site [chemical binding]; other site
591020010206	magnesium binding site [ion binding]; other site
591020010207	putative shikimate binding site; other site
591020010208	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
591020010209	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
591020010210	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
591020010211	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
591020010212	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
591020010213	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
591020010214	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
591020010215	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
591020010216	Transglycosylase; Region: Transgly; pfam00912
591020010217	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
591020010218	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
591020010219	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
591020010220	ADP-ribose binding site [chemical binding]; other site
591020010221	dimer interface [polypeptide binding]; other site
591020010222	active site
591020010223	nudix motif; other site
591020010224	metal binding site [ion binding]; metal-binding site
591020010225	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
591020010226	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
591020010227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020010228	motif II; other site
591020010229	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020010230	RNA binding surface [nucleotide binding]; other site
591020010231	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
591020010232	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
591020010233	dimerization interface [polypeptide binding]; other site
591020010234	domain crossover interface; other site
591020010235	redox-dependent activation switch; other site
591020010236	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
591020010237	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
591020010238	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
591020010239	active site
591020010240	substrate-binding site [chemical binding]; other site
591020010241	metal-binding site [ion binding]
591020010242	ATP binding site [chemical binding]; other site
591020010243	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
591020010244	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020010245	dimerization interface [polypeptide binding]; other site
591020010246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020010247	dimer interface [polypeptide binding]; other site
591020010248	phosphorylation site [posttranslational modification]
591020010249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020010250	ATP binding site [chemical binding]; other site
591020010251	G-X-G motif; other site
591020010252	osmolarity response regulator; Provisional; Region: ompR; PRK09468
591020010253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020010254	active site
591020010255	phosphorylation site [posttranslational modification]
591020010256	intermolecular recognition site; other site
591020010257	dimerization interface [polypeptide binding]; other site
591020010258	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020010259	DNA binding site [nucleotide binding]
591020010260	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
591020010261	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
591020010262	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
591020010263	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
591020010264	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
591020010265	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
591020010266	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
591020010267	RNA binding site [nucleotide binding]; other site
591020010268	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
591020010269	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
591020010270	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
591020010271	G1 box; other site
591020010272	GTP/Mg2+ binding site [chemical binding]; other site
591020010273	Switch I region; other site
591020010274	G2 box; other site
591020010275	G3 box; other site
591020010276	Switch II region; other site
591020010277	G4 box; other site
591020010278	G5 box; other site
591020010279	Nucleoside recognition; Region: Gate; pfam07670
591020010280	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
591020010281	Nucleoside recognition; Region: Gate; pfam07670
591020010282	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
591020010283	putative transposase; Provisional; Region: PRK09857
591020010284	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
591020010285	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020010286	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020010287	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020010288	HTH-like domain; Region: HTH_21; pfam13276
591020010289	Integrase core domain; Region: rve; pfam00665
591020010290	Integrase core domain; Region: rve_3; pfam13683
591020010291	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
591020010292	PemK-like protein; Region: PemK; pfam02452
591020010293	carboxylesterase BioH; Provisional; Region: PRK10349
591020010294	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
591020010295	DNA utilization protein GntX; Provisional; Region: PRK11595
591020010296	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020010297	active site
591020010298	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
591020010299	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
591020010300	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
591020010301	high-affinity gluconate transporter; Provisional; Region: PRK14984
591020010302	gluconate transporter; Region: gntP; TIGR00791
591020010303	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
591020010304	4-alpha-glucanotransferase; Region: malQ; TIGR00217
591020010305	maltodextrin phosphorylase; Provisional; Region: PRK14985
591020010306	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
591020010307	active site pocket [active]
591020010308	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
591020010309	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
591020010310	putative active site [active]
591020010311	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
591020010312	hypothetical protein; Reviewed; Region: PRK09588
591020010313	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
591020010314	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
591020010315	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020010316	Walker A motif; other site
591020010317	ATP binding site [chemical binding]; other site
591020010318	Walker B motif; other site
591020010319	arginine finger; other site
591020010320	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
591020010321	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591020010322	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020010323	intramembrane serine protease GlpG; Provisional; Region: PRK10907
591020010324	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
591020010325	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
591020010326	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
591020010327	active site residue [active]
591020010328	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
591020010329	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020010330	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020010331	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020010332	glycogen phosphorylase; Provisional; Region: PRK14986
591020010333	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
591020010334	homodimer interface [polypeptide binding]; other site
591020010335	active site pocket [active]
591020010336	glycogen synthase; Provisional; Region: glgA; PRK00654
591020010337	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
591020010338	ADP-binding pocket [chemical binding]; other site
591020010339	homodimer interface [polypeptide binding]; other site
591020010340	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
591020010341	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
591020010342	ligand binding site; other site
591020010343	oligomer interface; other site
591020010344	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
591020010345	sulfate 1 binding site; other site
591020010346	glycogen debranching enzyme; Provisional; Region: PRK03705
591020010347	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
591020010348	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
591020010349	active site
591020010350	catalytic site [active]
591020010351	glycogen branching enzyme; Provisional; Region: PRK05402
591020010352	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
591020010353	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
591020010354	active site
591020010355	catalytic site [active]
591020010356	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
591020010357	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
591020010358	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
591020010359	putative antibiotic transporter; Provisional; Region: PRK10739
591020010360	low affinity gluconate transporter; Provisional; Region: PRK10472
591020010361	gluconate transporter; Region: gntP; TIGR00791
591020010362	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
591020010363	ATP-binding site [chemical binding]; other site
591020010364	Gluconate-6-phosphate binding site [chemical binding]; other site
591020010365	Shikimate kinase; Region: SKI; pfam01202
591020010366	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
591020010367	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020010368	DNA binding site [nucleotide binding]
591020010369	domain linker motif; other site
591020010370	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
591020010371	putative ligand binding site [chemical binding]; other site
591020010372	putative dimerization interface [polypeptide binding]; other site
591020010373	Pirin-related protein [General function prediction only]; Region: COG1741
591020010374	Pirin; Region: Pirin; pfam02678
591020010375	putative oxidoreductase; Provisional; Region: PRK10206
591020010376	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
591020010377	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
591020010378	putative acetyltransferase YhhY; Provisional; Region: PRK10140
591020010379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020010380	Coenzyme A binding pocket [chemical binding]; other site
591020010381	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
591020010382	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
591020010383	hypothetical protein; Provisional; Region: PRK10350
591020010384	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
591020010385	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
591020010386	putative active site [active]
591020010387	catalytic site [active]
591020010388	putative metal binding site [ion binding]; other site
591020010389	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
591020010390	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
591020010391	Walker A/P-loop; other site
591020010392	ATP binding site [chemical binding]; other site
591020010393	Q-loop/lid; other site
591020010394	ABC transporter signature motif; other site
591020010395	Walker B; other site
591020010396	D-loop; other site
591020010397	H-loop/switch region; other site
591020010398	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591020010399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020010400	dimer interface [polypeptide binding]; other site
591020010401	conserved gate region; other site
591020010402	putative PBP binding loops; other site
591020010403	ABC-ATPase subunit interface; other site
591020010404	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
591020010405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020010406	dimer interface [polypeptide binding]; other site
591020010407	conserved gate region; other site
591020010408	putative PBP binding loops; other site
591020010409	ABC-ATPase subunit interface; other site
591020010410	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
591020010411	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
591020010412	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
591020010413	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
591020010414	Walker A/P-loop; other site
591020010415	ATP binding site [chemical binding]; other site
591020010416	Q-loop/lid; other site
591020010417	ABC transporter signature motif; other site
591020010418	Walker B; other site
591020010419	D-loop; other site
591020010420	H-loop/switch region; other site
591020010421	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
591020010422	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
591020010423	Walker A/P-loop; other site
591020010424	ATP binding site [chemical binding]; other site
591020010425	Q-loop/lid; other site
591020010426	ABC transporter signature motif; other site
591020010427	Walker B; other site
591020010428	D-loop; other site
591020010429	H-loop/switch region; other site
591020010430	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
591020010431	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
591020010432	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
591020010433	TM-ABC transporter signature motif; other site
591020010434	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020010435	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
591020010436	TM-ABC transporter signature motif; other site
591020010437	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
591020010438	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
591020010439	dimerization interface [polypeptide binding]; other site
591020010440	ligand binding site [chemical binding]; other site
591020010441	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
591020010442	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
591020010443	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
591020010444	dimerization interface [polypeptide binding]; other site
591020010445	ligand binding site [chemical binding]; other site
591020010446	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
591020010447	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
591020010448	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
591020010449	DNA binding residues [nucleotide binding]
591020010450	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
591020010451	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
591020010452	cell division protein FtsE; Provisional; Region: PRK10908
591020010453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020010454	Walker A/P-loop; other site
591020010455	ATP binding site [chemical binding]; other site
591020010456	Q-loop/lid; other site
591020010457	ABC transporter signature motif; other site
591020010458	Walker B; other site
591020010459	D-loop; other site
591020010460	H-loop/switch region; other site
591020010461	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
591020010462	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
591020010463	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
591020010464	P loop; other site
591020010465	GTP binding site [chemical binding]; other site
591020010466	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
591020010467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020010468	S-adenosylmethionine binding site [chemical binding]; other site
591020010469	hypothetical protein; Provisional; Region: PRK10910
591020010470	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
591020010471	Predicted membrane protein [Function unknown]; Region: COG3714
591020010472	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
591020010473	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
591020010474	metal-binding site [ion binding]
591020010475	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591020010476	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
591020010477	CPxP  motif; other site
591020010478	hypothetical protein; Provisional; Region: PRK11212
591020010479	hypothetical protein; Provisional; Region: PRK11615
591020010480	major facilitator superfamily transporter; Provisional; Region: PRK05122
591020010481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020010482	putative substrate translocation pore; other site
591020010483	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
591020010484	Domain of unknown function DUF20; Region: UPF0118; pfam01594
591020010485	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
591020010486	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
591020010487	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
591020010488	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
591020010489	substrate binding site [chemical binding]; other site
591020010490	nickel transporter permease NikB; Provisional; Region: PRK10352
591020010491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020010492	dimer interface [polypeptide binding]; other site
591020010493	conserved gate region; other site
591020010494	putative PBP binding loops; other site
591020010495	ABC-ATPase subunit interface; other site
591020010496	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
591020010497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020010498	dimer interface [polypeptide binding]; other site
591020010499	conserved gate region; other site
591020010500	putative PBP binding loops; other site
591020010501	ABC-ATPase subunit interface; other site
591020010502	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
591020010503	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020010504	Walker A/P-loop; other site
591020010505	ATP binding site [chemical binding]; other site
591020010506	Q-loop/lid; other site
591020010507	ABC transporter signature motif; other site
591020010508	Walker B; other site
591020010509	D-loop; other site
591020010510	H-loop/switch region; other site
591020010511	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
591020010512	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
591020010513	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020010514	Walker A/P-loop; other site
591020010515	ATP binding site [chemical binding]; other site
591020010516	Q-loop/lid; other site
591020010517	ABC transporter signature motif; other site
591020010518	Walker B; other site
591020010519	D-loop; other site
591020010520	H-loop/switch region; other site
591020010521	nickel responsive regulator; Provisional; Region: PRK02967
591020010522	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
591020010523	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
591020010524	HicB family; Region: HicB; pfam05534
591020010525	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591020010526	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
591020010527	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591020010528	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
591020010529	Walker A/P-loop; other site
591020010530	ATP binding site [chemical binding]; other site
591020010531	Q-loop/lid; other site
591020010532	ABC transporter signature motif; other site
591020010533	Walker B; other site
591020010534	D-loop; other site
591020010535	H-loop/switch region; other site
591020010536	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
591020010537	Walker A/P-loop; other site
591020010538	ATP binding site [chemical binding]; other site
591020010539	Q-loop/lid; other site
591020010540	ABC transporter signature motif; other site
591020010541	Walker B; other site
591020010542	D-loop; other site
591020010543	H-loop/switch region; other site
591020010544	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
591020010545	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
591020010546	HlyD family secretion protein; Region: HlyD; pfam00529
591020010547	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020010548	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020010549	Domain of unknown function (DUF4049); Region: DUF4049; pfam13258
591020010550	Domain of unknown function (DUF4049); Region: DUF4049; pfam13258
591020010551	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
591020010552	DNA binding site [nucleotide binding]
591020010553	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
591020010554	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020010555	PapC C-terminal domain; Region: PapC_C; pfam13953
591020010556	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
591020010557	PapC N-terminal domain; Region: PapC_N; pfam13954
591020010558	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020010559	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
591020010560	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591020010561	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591020010562	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
591020010563	dimerization interface [polypeptide binding]; other site
591020010564	DNA binding residues [nucleotide binding]
591020010565	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
591020010566	O-Antigen ligase; Region: Wzy_C; pfam04932
591020010567	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
591020010568	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020010569	Transposase; Region: HTH_Tnp_1; pfam01527
591020010570	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010571	Predicted flavoproteins [General function prediction only]; Region: COG2081
591020010572	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591020010573	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
591020010574	universal stress protein UspB; Provisional; Region: PRK04960
591020010575	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591020010576	Ligand Binding Site [chemical binding]; other site
591020010577	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
591020010578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020010579	putative substrate translocation pore; other site
591020010580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020010581	S-adenosylmethionine binding site [chemical binding]; other site
591020010582	oligopeptidase A; Provisional; Region: PRK10911
591020010583	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
591020010584	active site
591020010585	Zn binding site [ion binding]; other site
591020010586	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
591020010587	glutathione reductase; Validated; Region: PRK06116
591020010588	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591020010589	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020010590	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591020010591	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010592	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
591020010593	ArsC family; Region: ArsC; pfam03960
591020010594	catalytic residues [active]
591020010595	arsenical pump membrane protein; Provisional; Region: PRK15445
591020010596	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
591020010597	transmembrane helices; other site
591020010598	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010599	Predicted permeases [General function prediction only]; Region: COG0701
591020010600	outer membrane lipoprotein, Slp family; Region: slp; TIGR00752
591020010601	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591020010602	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020010603	DNA binding residues [nucleotide binding]
591020010604	dimerization interface [polypeptide binding]; other site
591020010605	acid-resistance protein; Provisional; Region: hdeB; PRK11566
591020010606	acid-resistance protein; Provisional; Region: PRK10208
591020010607	acid-resistance membrane protein; Provisional; Region: PRK10209
591020010608	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
591020010609	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
591020010610	pyruvate kinase; Provisional; Region: PRK05826
591020010611	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020010612	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020010613	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010614	trehalase; Provisional; Region: treF; PRK13270
591020010615	Trehalase; Region: Trehalase; pfam01204
591020010616	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020010617	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020010618	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020010619	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591020010620	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020010621	DNA binding residues [nucleotide binding]
591020010622	dimerization interface [polypeptide binding]; other site
591020010623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
591020010624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020010625	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
591020010626	putative effector binding pocket; other site
591020010627	putative dimerization interface [polypeptide binding]; other site
591020010628	inner membrane protein YhjD; Region: TIGR00766
591020010629	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020010630	metabolite-proton symporter; Region: 2A0106; TIGR00883
591020010631	putative substrate translocation pore; other site
591020010632	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
591020010633	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
591020010634	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020010635	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020010636	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
591020010637	substrate binding site [chemical binding]; other site
591020010638	ATP binding site [chemical binding]; other site
591020010639	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
591020010640	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
591020010641	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
591020010642	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591020010643	putative diguanylate cyclase; Provisional; Region: PRK13561
591020010644	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
591020010645	metal binding site [ion binding]; metal-binding site
591020010646	active site
591020010647	I-site; other site
591020010648	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
591020010649	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
591020010650	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
591020010651	endo-1,4-D-glucanase; Provisional; Region: PRK11097
591020010652	cellulose synthase regulator protein; Provisional; Region: PRK11114
591020010653	cell division protein; Provisional; Region: PRK10037
591020010654	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
591020010655	P-loop; other site
591020010656	Magnesium ion binding site [ion binding]; other site
591020010657	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
591020010658	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
591020010659	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
591020010660	Protein of unknown function (DUF2636); Region: DUF2636; cl11897
591020010661	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
591020010662	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
591020010663	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
591020010664	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
591020010665	serine transporter; Region: stp; TIGR00814
591020010666	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
591020010667	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020010668	Walker A/P-loop; other site
591020010669	ATP binding site [chemical binding]; other site
591020010670	Q-loop/lid; other site
591020010671	ABC transporter signature motif; other site
591020010672	Walker B; other site
591020010673	D-loop; other site
591020010674	H-loop/switch region; other site
591020010675	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591020010676	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
591020010677	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
591020010678	Walker A/P-loop; other site
591020010679	ATP binding site [chemical binding]; other site
591020010680	Q-loop/lid; other site
591020010681	ABC transporter signature motif; other site
591020010682	Walker B; other site
591020010683	D-loop; other site
591020010684	H-loop/switch region; other site
591020010685	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
591020010686	dipeptide transporter; Provisional; Region: PRK10913
591020010687	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
591020010688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020010689	dimer interface [polypeptide binding]; other site
591020010690	conserved gate region; other site
591020010691	putative PBP binding loops; other site
591020010692	ABC-ATPase subunit interface; other site
591020010693	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
591020010694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020010695	dimer interface [polypeptide binding]; other site
591020010696	conserved gate region; other site
591020010697	putative PBP binding loops; other site
591020010698	ABC-ATPase subunit interface; other site
591020010699	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
591020010700	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
591020010701	peptide binding site [polypeptide binding]; other site
591020010702	phosphoethanolamine transferase; Provisional; Region: PRK11560
591020010703	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
591020010704	Sulfatase; Region: Sulfatase; pfam00884
591020010705	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
591020010706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020010707	putative substrate translocation pore; other site
591020010708	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
591020010709	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
591020010710	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591020010711	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020010712	Coenzyme A binding pocket [chemical binding]; other site
591020010713	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
591020010714	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
591020010715	molybdopterin cofactor binding site [chemical binding]; other site
591020010716	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
591020010717	molybdopterin cofactor binding site; other site
591020010718	putative outer membrane lipoprotein; Provisional; Region: PRK10510
591020010719	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
591020010720	ligand binding site [chemical binding]; other site
591020010721	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
591020010722	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
591020010723	dimerization interface [polypeptide binding]; other site
591020010724	ligand binding site [chemical binding]; other site
591020010725	NADP binding site [chemical binding]; other site
591020010726	catalytic site [active]
591020010727	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
591020010728	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
591020010729	DNA-binding site [nucleotide binding]; DNA binding site
591020010730	RNA-binding motif; other site
591020010731	Hok/gef family; Region: HOK_GEF; cl11494
591020010732	putative transposase OrfB; Reviewed; Region: PHA02517
591020010733	HTH-like domain; Region: HTH_21; pfam13276
591020010734	Integrase core domain; Region: rve; pfam00665
591020010735	Integrase core domain; Region: rve_2; pfam13333
591020010736	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020010737	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020010738	Helix-turn-helix domain; Region: HTH_28; pfam13518
591020010739	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010740	Haem-binding domain; Region: Haem_bd; pfam14376
591020010741	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
591020010742	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
591020010743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020010744	catalytic residue [active]
591020010745	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
591020010746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020010747	transcriptional regulator YdeO; Provisional; Region: PRK09940
591020010748	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020010749	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
591020010750	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010751	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
591020010752	DALR anticodon binding domain; Region: DALR_1; pfam05746
591020010753	anticodon binding site; other site
591020010754	tRNA binding surface [nucleotide binding]; other site
591020010755	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
591020010756	dimer interface [polypeptide binding]; other site
591020010757	motif 1; other site
591020010758	active site
591020010759	motif 2; other site
591020010760	motif 3; other site
591020010761	YsaB-like lipoprotein; Region: YsaB; pfam13983
591020010762	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
591020010763	Acyltransferase family; Region: Acyl_transf_3; pfam01757
591020010764	hypothetical protein; Provisional; Region: PRK11383
591020010765	yiaA/B two helix domain; Region: YiaAB; pfam05360
591020010766	yiaA/B two helix domain; Region: YiaAB; pfam05360
591020010767	hypothetical protein; Provisional; Region: PRK11403
591020010768	yiaA/B two helix domain; Region: YiaAB; pfam05360
591020010769	xylulokinase; Provisional; Region: PRK15027
591020010770	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
591020010771	N- and C-terminal domain interface [polypeptide binding]; other site
591020010772	active site
591020010773	MgATP binding site [chemical binding]; other site
591020010774	catalytic site [active]
591020010775	metal binding site [ion binding]; metal-binding site
591020010776	xylulose binding site [chemical binding]; other site
591020010777	homodimer interface [polypeptide binding]; other site
591020010778	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
591020010779	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
591020010780	putative ligand binding site [chemical binding]; other site
591020010781	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020010782	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020010783	TM-ABC transporter signature motif; other site
591020010784	hypothetical protein; Provisional; Region: PRK10356
591020010785	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
591020010786	alpha-amylase; Reviewed; Region: malS; PRK09505
591020010787	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
591020010788	active site
591020010789	catalytic site [active]
591020010790	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
591020010791	Transcriptional regulator [Transcription]; Region: IclR; COG1414
591020010792	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591020010793	Bacterial transcriptional regulator; Region: IclR; pfam01614
591020010794	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
591020010795	Domain of unknown function (DUF386); Region: DUF386; cl01047
591020010796	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010797	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
591020010798	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
591020010799	DctM-like transporters; Region: DctM; pfam06808
591020010800	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010801	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
591020010802	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
591020010803	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
591020010804	NAD(P) binding site [chemical binding]; other site
591020010805	catalytic residues [active]
591020010806	putative alcohol dehydrogenase; Provisional; Region: PRK09860
591020010807	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
591020010808	dimer interface [polypeptide binding]; other site
591020010809	active site
591020010810	metal binding site [ion binding]; metal-binding site
591020010811	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
591020010812	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
591020010813	G1 box; other site
591020010814	putative GEF interaction site [polypeptide binding]; other site
591020010815	GTP/Mg2+ binding site [chemical binding]; other site
591020010816	Switch I region; other site
591020010817	G2 box; other site
591020010818	G3 box; other site
591020010819	Switch II region; other site
591020010820	G4 box; other site
591020010821	G5 box; other site
591020010822	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
591020010823	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
591020010824	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
591020010825	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
591020010826	selenocysteine synthase; Provisional; Region: PRK04311
591020010827	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
591020010828	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
591020010829	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591020010830	catalytic residue [active]
591020010831	putative glutathione S-transferase; Provisional; Region: PRK10357
591020010832	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
591020010833	putative C-terminal domain interface [polypeptide binding]; other site
591020010834	putative GSH binding site (G-site) [chemical binding]; other site
591020010835	putative dimer interface [polypeptide binding]; other site
591020010836	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
591020010837	dimer interface [polypeptide binding]; other site
591020010838	N-terminal domain interface [polypeptide binding]; other site
591020010839	putative substrate binding pocket (H-site) [chemical binding]; other site
591020010840	HlyD family secretion protein; Region: HlyD; pfam00529
591020010841	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020010842	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020010843	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
591020010844	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
591020010845	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
591020010846	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
591020010847	active site
591020010848	P-loop; other site
591020010849	phosphorylation site [posttranslational modification]
591020010850	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020010851	active site
591020010852	phosphorylation site [posttranslational modification]
591020010853	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
591020010854	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591020010855	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591020010856	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
591020010857	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
591020010858	hypothetical protein; Provisional; Region: PRK11020
591020010859	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010860	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
591020010861	L-lactate permease; Provisional; Region: PRK10420
591020010862	glycolate transporter; Provisional; Region: PRK09695
591020010863	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
591020010864	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020010865	DNA-binding site [nucleotide binding]; DNA binding site
591020010866	FCD domain; Region: FCD; pfam07729
591020010867	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
591020010868	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
591020010869	phosphate binding site [ion binding]; other site
591020010870	putative rRNA methylase; Provisional; Region: PRK10358
591020010871	serine acetyltransferase; Provisional; Region: cysE; PRK11132
591020010872	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
591020010873	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
591020010874	trimer interface [polypeptide binding]; other site
591020010875	active site
591020010876	substrate binding site [chemical binding]; other site
591020010877	CoA binding site [chemical binding]; other site
591020010878	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
591020010879	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
591020010880	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
591020010881	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
591020010882	SecA binding site; other site
591020010883	Preprotein binding site; other site
591020010884	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
591020010885	GSH binding site [chemical binding]; other site
591020010886	catalytic residues [active]
591020010887	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
591020010888	active site residue [active]
591020010889	phosphoglyceromutase; Provisional; Region: PRK05434
591020010890	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
591020010891	AmiB activator; Provisional; Region: PRK11637
591020010892	Peptidase family M23; Region: Peptidase_M23; pfam01551
591020010893	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
591020010894	NodB motif; other site
591020010895	putative active site [active]
591020010896	putative catalytic site [active]
591020010897	Zn binding site [ion binding]; other site
591020010898	putative glycosyl transferase; Provisional; Region: PRK10073
591020010899	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010900	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
591020010901	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
591020010902	NAD(P) binding site [chemical binding]; other site
591020010903	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
591020010904	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
591020010905	substrate-cofactor binding pocket; other site
591020010906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020010907	catalytic residue [active]
591020010908	hypothetical protein; Provisional; Region: PRK11346
591020010909	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
591020010910	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
591020010911	NADP binding site [chemical binding]; other site
591020010912	homopentamer interface [polypeptide binding]; other site
591020010913	substrate binding site [chemical binding]; other site
591020010914	active site
591020010915	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
591020010916	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
591020010917	putative active site [active]
591020010918	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
591020010919	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
591020010920	putative active site [active]
591020010921	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
591020010922	O-antigen ligase RfaL; Provisional; Region: PRK15487
591020010923	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
591020010924	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
591020010925	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
591020010926	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
591020010927	Ligand binding site; other site
591020010928	metal-binding site
591020010929	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
591020010930	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526
591020010931	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
591020010932	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
591020010933	Ligand binding site; other site
591020010934	metal-binding site
591020010935	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
591020010936	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
591020010937	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
591020010938	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
591020010939	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
591020010940	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
591020010941	putative active site [active]
591020010942	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020010943	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
591020010944	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
591020010945	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
591020010946	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
591020010947	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
591020010948	active site
591020010949	(T/H)XGH motif; other site
591020010950	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
591020010951	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
591020010952	DNA binding site [nucleotide binding]
591020010953	catalytic residue [active]
591020010954	H2TH interface [polypeptide binding]; other site
591020010955	putative catalytic residues [active]
591020010956	turnover-facilitating residue; other site
591020010957	intercalation triad [nucleotide binding]; other site
591020010958	8OG recognition residue [nucleotide binding]; other site
591020010959	putative reading head residues; other site
591020010960	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
591020010961	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
591020010962	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
591020010963	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
591020010964	hypothetical protein; Reviewed; Region: PRK00024
591020010965	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
591020010966	MPN+ (JAMM) motif; other site
591020010967	Zinc-binding site [ion binding]; other site
591020010968	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
591020010969	Flavoprotein; Region: Flavoprotein; pfam02441
591020010970	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
591020010971	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
591020010972	trimer interface [polypeptide binding]; other site
591020010973	active site
591020010974	division inhibitor protein; Provisional; Region: slmA; PRK09480
591020010975	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020010976	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
591020010977	active site
591020010978	ribonuclease PH; Reviewed; Region: rph; PRK00173
591020010979	Ribonuclease PH; Region: RNase_PH_bact; cd11362
591020010980	hexamer interface [polypeptide binding]; other site
591020010981	active site
591020010982	hypothetical protein; Provisional; Region: PRK11820
591020010983	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
591020010984	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
591020010985	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
591020010986	BRO family, N-terminal domain; Region: Bro-N; pfam02498
591020010987	Predicted membrane protein [Function unknown]; Region: COG2860
591020010988	UPF0126 domain; Region: UPF0126; pfam03458
591020010989	UPF0126 domain; Region: UPF0126; pfam03458
591020010990	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
591020010991	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
591020010992	nucleotide binding pocket [chemical binding]; other site
591020010993	K-X-D-G motif; other site
591020010994	catalytic site [active]
591020010995	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
591020010996	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
591020010997	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
591020010998	catalytic site [active]
591020010999	G-X2-G-X-G-K; other site
591020011000	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
591020011001	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
591020011002	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
591020011003	Zn2+ binding site [ion binding]; other site
591020011004	Mg2+ binding site [ion binding]; other site
591020011005	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
591020011006	synthetase active site [active]
591020011007	NTP binding site [chemical binding]; other site
591020011008	metal binding site [ion binding]; metal-binding site
591020011009	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
591020011010	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
591020011011	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
591020011012	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591020011013	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
591020011014	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
591020011015	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
591020011016	generic binding surface II; other site
591020011017	ssDNA binding site; other site
591020011018	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020011019	ATP binding site [chemical binding]; other site
591020011020	putative Mg++ binding site [ion binding]; other site
591020011021	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020011022	nucleotide binding region [chemical binding]; other site
591020011023	ATP-binding site [chemical binding]; other site
591020011024	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
591020011025	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
591020011026	AsmA family; Region: AsmA; pfam05170
591020011027	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
591020011028	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
591020011029	putative alpha-glucosidase; Provisional; Region: PRK10658
591020011030	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
591020011031	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
591020011032	active site
591020011033	homotrimer interface [polypeptide binding]; other site
591020011034	catalytic site [active]
591020011035	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
591020011036	integrase; Provisional; Region: PRK09692
591020011037	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591020011038	active site
591020011039	Int/Topo IB signature motif; other site
591020011040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
591020011041	TPR motif; other site
591020011042	binding surface
591020011043	Integrase core domain; Region: rve; pfam00665
591020011044	Integrase core domain; Region: rve_2; pfam13333
591020011045	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
591020011046	Transposase; Region: HTH_Tnp_1; cl17663
591020011047	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020011048	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020011049	HTH-like domain; Region: HTH_21; pfam13276
591020011050	Integrase core domain; Region: rve; pfam00665
591020011051	Integrase core domain; Region: rve_3; pfam13683
591020011052	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020011053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020011054	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011056	Major Facilitator Superfamily; Region: MFS_1; pfam07690
591020011057	putative substrate translocation pore; other site
591020011058	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
591020011059	IucA / IucC family; Region: IucA_IucC; pfam04183
591020011060	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
591020011061	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
591020011062	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
591020011063	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
591020011064	IucA / IucC family; Region: IucA_IucC; pfam04183
591020011065	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
591020011066	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
591020011067	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
591020011068	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
591020011069	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591020011070	N-terminal plug; other site
591020011071	ligand-binding site [chemical binding]; other site
591020011072	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
591020011073	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020011074	HTH-like domain; Region: HTH_21; pfam13276
591020011075	Integrase core domain; Region: rve; pfam00665
591020011076	Integrase core domain; Region: rve_3; pfam13683
591020011077	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020011078	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020011079	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
591020011080	PapC N-terminal domain; Region: PapC_N; pfam13954
591020011081	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
591020011082	PapC C-terminal domain; Region: PapC_C; pfam13953
591020011083	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011084	Fimbrial protein; Region: Fimbrial; cl01416
591020011085	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
591020011086	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
591020011087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020011088	dimer interface [polypeptide binding]; other site
591020011089	conserved gate region; other site
591020011090	putative PBP binding loops; other site
591020011091	ABC-ATPase subunit interface; other site
591020011092	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
591020011093	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020011094	dimer interface [polypeptide binding]; other site
591020011095	conserved gate region; other site
591020011096	putative PBP binding loops; other site
591020011097	ABC-ATPase subunit interface; other site
591020011098	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
591020011099	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
591020011100	Walker A/P-loop; other site
591020011101	ATP binding site [chemical binding]; other site
591020011102	Q-loop/lid; other site
591020011103	ABC transporter signature motif; other site
591020011104	Walker B; other site
591020011105	D-loop; other site
591020011106	H-loop/switch region; other site
591020011107	transcriptional regulator PhoU; Provisional; Region: PRK11115
591020011108	PhoU domain; Region: PhoU; pfam01895
591020011109	PhoU domain; Region: PhoU; pfam01895
591020011110	transcriptional antiterminator BglG; Provisional; Region: PRK09772
591020011111	CAT RNA binding domain; Region: CAT_RBD; pfam03123
591020011112	PRD domain; Region: PRD; pfam00874
591020011113	PRD domain; Region: PRD; pfam00874
591020011114	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
591020011115	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591020011116	active site turn [active]
591020011117	phosphorylation site [posttranslational modification]
591020011118	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
591020011119	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
591020011120	HPr interaction site; other site
591020011121	glycerol kinase (GK) interaction site [polypeptide binding]; other site
591020011122	active site
591020011123	phosphorylation site [posttranslational modification]
591020011124	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
591020011125	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011126	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
591020011127	motif I; other site
591020011128	active site
591020011129	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591020011130	Predicted flavoprotein [General function prediction only]; Region: COG0431
591020011131	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
591020011132	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
591020011133	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
591020011134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011135	putative substrate translocation pore; other site
591020011136	tryptophan permease TnaB; Provisional; Region: PRK09664
591020011137	aromatic amino acid transport protein; Region: araaP; TIGR00837
591020011138	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
591020011139	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
591020011140	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
591020011141	catalytic residue [active]
591020011142	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011143	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
591020011144	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
591020011145	trmE is a tRNA modification GTPase; Region: trmE; cd04164
591020011146	G1 box; other site
591020011147	GTP/Mg2+ binding site [chemical binding]; other site
591020011148	Switch I region; other site
591020011149	G2 box; other site
591020011150	Switch II region; other site
591020011151	G3 box; other site
591020011152	G4 box; other site
591020011153	G5 box; other site
591020011154	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
591020011155	membrane protein insertase; Provisional; Region: PRK01318
591020011156	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
591020011157	hypothetical protein; Validated; Region: PRK00041
591020011158	ribonuclease P; Reviewed; Region: rnpA; PRK01732
591020011159	DnaA N-terminal domain; Region: DnaA_N; pfam11638
591020011160	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
591020011161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020011162	Walker A motif; other site
591020011163	ATP binding site [chemical binding]; other site
591020011164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591020011165	Walker B motif; other site
591020011166	arginine finger; other site
591020011167	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
591020011168	DnaA box-binding interface [nucleotide binding]; other site
591020011169	DNA polymerase III subunit beta; Validated; Region: PRK05643
591020011170	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
591020011171	putative DNA binding surface [nucleotide binding]; other site
591020011172	dimer interface [polypeptide binding]; other site
591020011173	beta-clamp/clamp loader binding surface; other site
591020011174	beta-clamp/translesion DNA polymerase binding surface; other site
591020011175	recF protein; Region: recf; TIGR00611
591020011176	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020011177	Walker A/P-loop; other site
591020011178	ATP binding site [chemical binding]; other site
591020011179	Q-loop/lid; other site
591020011180	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020011181	ABC transporter signature motif; other site
591020011182	Walker B; other site
591020011183	D-loop; other site
591020011184	H-loop/switch region; other site
591020011185	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
591020011186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020011187	Mg2+ binding site [ion binding]; other site
591020011188	G-X-G motif; other site
591020011189	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
591020011190	anchoring element; other site
591020011191	dimer interface [polypeptide binding]; other site
591020011192	ATP binding site [chemical binding]; other site
591020011193	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
591020011194	active site
591020011195	putative metal-binding site [ion binding]; other site
591020011196	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
591020011197	hypothetical protein; Provisional; Region: PRK11426
591020011198	sugar phosphate phosphatase; Provisional; Region: PRK10513
591020011199	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020011200	active site
591020011201	motif I; other site
591020011202	motif II; other site
591020011203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020011204	hypothetical protein; Provisional; Region: PRK10215
591020011205	Transcriptional regulators [Transcription]; Region: FadR; COG2186
591020011206	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020011207	DNA-binding site [nucleotide binding]; DNA binding site
591020011208	FCD domain; Region: FCD; pfam07729
591020011209	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
591020011210	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
591020011211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011212	D-galactonate transporter; Region: 2A0114; TIGR00893
591020011213	putative substrate translocation pore; other site
591020011214	putative oxidoreductase; Provisional; Region: PRK11445
591020011215	hypothetical protein; Provisional; Region: PRK07236
591020011216	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
591020011217	hypothetical protein; Provisional; Region: PRK11616
591020011218	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
591020011219	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
591020011220	putative dimer interface [polypeptide binding]; other site
591020011221	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
591020011222	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
591020011223	putative dimer interface [polypeptide binding]; other site
591020011224	putative transporter; Validated; Region: PRK03818
591020011225	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
591020011226	TrkA-C domain; Region: TrkA_C; pfam02080
591020011227	TrkA-C domain; Region: TrkA_C; pfam02080
591020011228	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
591020011229	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
591020011230	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020011231	DNA-binding site [nucleotide binding]; DNA binding site
591020011232	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
591020011233	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
591020011234	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
591020011235	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
591020011236	active site turn [active]
591020011237	phosphorylation site [posttranslational modification]
591020011238	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591020011239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020011240	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591020011241	putative transporter; Provisional; Region: PRK10484
591020011242	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
591020011243	Na binding site [ion binding]; other site
591020011244	Domain of unknown function (DUF202); Region: DUF202; pfam02656
591020011245	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
591020011246	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
591020011247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011248	putative substrate translocation pore; other site
591020011249	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
591020011250	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591020011251	PYR/PP interface [polypeptide binding]; other site
591020011252	dimer interface [polypeptide binding]; other site
591020011253	TPP binding site [chemical binding]; other site
591020011254	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591020011255	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
591020011256	TPP-binding site [chemical binding]; other site
591020011257	dimer interface [polypeptide binding]; other site
591020011258	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
591020011259	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
591020011260	putative valine binding site [chemical binding]; other site
591020011261	dimer interface [polypeptide binding]; other site
591020011262	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
591020011263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020011264	active site
591020011265	phosphorylation site [posttranslational modification]
591020011266	intermolecular recognition site; other site
591020011267	dimerization interface [polypeptide binding]; other site
591020011268	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020011269	DNA binding residues [nucleotide binding]
591020011270	dimerization interface [polypeptide binding]; other site
591020011271	sensory histidine kinase UhpB; Provisional; Region: PRK11644
591020011272	MASE1; Region: MASE1; pfam05231
591020011273	Histidine kinase; Region: HisKA_3; pfam07730
591020011274	regulatory protein UhpC; Provisional; Region: PRK11663
591020011275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011276	putative substrate translocation pore; other site
591020011277	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
591020011278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011279	putative substrate translocation pore; other site
591020011280	cryptic adenine deaminase; Provisional; Region: PRK10027
591020011281	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
591020011282	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
591020011283	active site
591020011284	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
591020011285	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591020011286	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
591020011287	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
591020011288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011289	putative substrate translocation pore; other site
591020011290	putative transposase OrfB; Reviewed; Region: PHA02517
591020011291	Integrase core domain; Region: rve; pfam00665
591020011292	Integrase core domain; Region: rve_3; pfam13683
591020011293	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
591020011294	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
591020011295	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020011296	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020011297	fimbrial protein; Provisional; Region: lpfA; PRK15289
591020011298	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020011299	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020011300	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020011301	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
591020011302	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
591020011303	folate binding site [chemical binding]; other site
591020011304	NADP+ binding site [chemical binding]; other site
591020011305	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020011306	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
591020011307	Coenzyme A binding pocket [chemical binding]; other site
591020011308	aminoglycoside resistance protein; Provisional; Region: PRK13746
591020011309	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
591020011310	active site
591020011311	NTP binding site [chemical binding]; other site
591020011312	metal binding triad [ion binding]; metal-binding site
591020011313	antibiotic binding site [chemical binding]; other site
591020011314	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
591020011315	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
591020011316	ATP-binding site [chemical binding]; other site
591020011317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020011318	AAA domain; Region: AAA_22; pfam13401
591020011319	Walker A motif; other site
591020011320	ATP binding site [chemical binding]; other site
591020011321	Walker B motif; other site
591020011322	Tn7 transposition regulator TnsC; Region: Tn7_TnsC_Int; pfam11426
591020011323	Integrase core domain; Region: rve; pfam00665
591020011324	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
591020011325	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
591020011326	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
591020011327	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
591020011328	glutaminase active site [active]
591020011329	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
591020011330	dimer interface [polypeptide binding]; other site
591020011331	active site
591020011332	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
591020011333	dimer interface [polypeptide binding]; other site
591020011334	active site
591020011335	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
591020011336	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
591020011337	Substrate binding site; other site
591020011338	Mg++ binding site; other site
591020011339	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
591020011340	active site
591020011341	substrate binding site [chemical binding]; other site
591020011342	CoA binding site [chemical binding]; other site
591020011343	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
591020011344	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
591020011345	gamma subunit interface [polypeptide binding]; other site
591020011346	epsilon subunit interface [polypeptide binding]; other site
591020011347	LBP interface [polypeptide binding]; other site
591020011348	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
591020011349	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591020011350	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
591020011351	alpha subunit interaction interface [polypeptide binding]; other site
591020011352	Walker A motif; other site
591020011353	ATP binding site [chemical binding]; other site
591020011354	Walker B motif; other site
591020011355	inhibitor binding site; inhibition site
591020011356	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591020011357	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
591020011358	core domain interface [polypeptide binding]; other site
591020011359	delta subunit interface [polypeptide binding]; other site
591020011360	epsilon subunit interface [polypeptide binding]; other site
591020011361	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
591020011362	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
591020011363	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
591020011364	beta subunit interaction interface [polypeptide binding]; other site
591020011365	Walker A motif; other site
591020011366	ATP binding site [chemical binding]; other site
591020011367	Walker B motif; other site
591020011368	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
591020011369	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
591020011370	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
591020011371	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
591020011372	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
591020011373	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
591020011374	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
591020011375	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
591020011376	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
591020011377	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
591020011378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020011379	S-adenosylmethionine binding site [chemical binding]; other site
591020011380	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
591020011381	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
591020011382	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
591020011383	FMN-binding protein MioC; Provisional; Region: PRK09004
591020011384	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
591020011385	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591020011386	putative DNA binding site [nucleotide binding]; other site
591020011387	putative Zn2+ binding site [ion binding]; other site
591020011388	AsnC family; Region: AsnC_trans_reg; pfam01037
591020011389	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
591020011390	dimer interface [polypeptide binding]; other site
591020011391	active site
591020011392	hypothetical protein; Provisional; Region: yieM; PRK10997
591020011393	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
591020011394	metal ion-dependent adhesion site (MIDAS); other site
591020011395	regulatory ATPase RavA; Provisional; Region: PRK13531
591020011396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020011397	Walker A motif; other site
591020011398	ATP binding site [chemical binding]; other site
591020011399	Walker B motif; other site
591020011400	arginine finger; other site
591020011401	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
591020011402	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020011403	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020011404	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020011405	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
591020011406	potassium uptake protein; Region: kup; TIGR00794
591020011407	D-ribose pyranase; Provisional; Region: PRK11797
591020011408	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591020011409	Walker A/P-loop; other site
591020011410	ATP binding site [chemical binding]; other site
591020011411	Q-loop/lid; other site
591020011412	ABC transporter signature motif; other site
591020011413	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011414	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591020011415	ABC transporter signature motif; other site
591020011416	Walker B; other site
591020011417	D-loop; other site
591020011418	H-loop/switch region; other site
591020011419	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591020011420	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020011421	Walker B; other site
591020011422	D-loop; other site
591020011423	H-loop/switch region; other site
591020011424	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020011425	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020011426	TM-ABC transporter signature motif; other site
591020011427	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
591020011428	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020011429	substrate binding site [chemical binding]; other site
591020011430	dimer interface [polypeptide binding]; other site
591020011431	ATP binding site [chemical binding]; other site
591020011432	transcriptional repressor RbsR; Provisional; Region: PRK10423
591020011433	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020011434	DNA binding site [nucleotide binding]
591020011435	domain linker motif; other site
591020011436	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
591020011437	dimerization interface [polypeptide binding]; other site
591020011438	ligand binding site [chemical binding]; other site
591020011439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011440	Transcriptional regulators [Transcription]; Region: FadR; COG2186
591020011441	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020011442	DNA-binding site [nucleotide binding]; DNA binding site
591020011443	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591020011444	transcriptional regulator HdfR; Provisional; Region: PRK03601
591020011445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020011446	LysR substrate binding domain; Region: LysR_substrate; pfam03466
591020011447	dimerization interface [polypeptide binding]; other site
591020011448	hypothetical protein; Provisional; Region: PRK11027
591020011449	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
591020011450	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
591020011451	PYR/PP interface [polypeptide binding]; other site
591020011452	dimer interface [polypeptide binding]; other site
591020011453	TPP binding site [chemical binding]; other site
591020011454	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
591020011455	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
591020011456	TPP-binding site [chemical binding]; other site
591020011457	dimer interface [polypeptide binding]; other site
591020011458	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
591020011459	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
591020011460	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
591020011461	homodimer interface [polypeptide binding]; other site
591020011462	substrate-cofactor binding pocket; other site
591020011463	catalytic residue [active]
591020011464	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
591020011465	threonine dehydratase; Reviewed; Region: PRK09224
591020011466	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
591020011467	tetramer interface [polypeptide binding]; other site
591020011468	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020011469	catalytic residue [active]
591020011470	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
591020011471	putative Ile/Val binding site [chemical binding]; other site
591020011472	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
591020011473	putative Ile/Val binding site [chemical binding]; other site
591020011474	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020011475	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
591020011476	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
591020011477	putative dimerization interface [polypeptide binding]; other site
591020011478	ketol-acid reductoisomerase; Validated; Region: PRK05225
591020011479	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
591020011480	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
591020011481	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
591020011482	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
591020011483	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
591020011484	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
591020011485	Part of AAA domain; Region: AAA_19; pfam13245
591020011486	Family description; Region: UvrD_C_2; pfam13538
591020011487	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
591020011488	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
591020011489	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
591020011490	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
591020011491	ATP binding site [chemical binding]; other site
591020011492	Mg++ binding site [ion binding]; other site
591020011493	motif III; other site
591020011494	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020011495	nucleotide binding region [chemical binding]; other site
591020011496	ATP-binding site [chemical binding]; other site
591020011497	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
591020011498	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
591020011499	catalytic residues [active]
591020011500	transcription termination factor Rho; Provisional; Region: rho; PRK09376
591020011501	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
591020011502	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
591020011503	RNA binding site [nucleotide binding]; other site
591020011504	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
591020011505	multimer interface [polypeptide binding]; other site
591020011506	Walker A motif; other site
591020011507	ATP binding site [chemical binding]; other site
591020011508	Walker B motif; other site
591020011509	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
591020011510	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
591020011511	Mg++ binding site [ion binding]; other site
591020011512	putative catalytic motif [active]
591020011513	substrate binding site [chemical binding]; other site
591020011514	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
591020011515	Chain length determinant protein; Region: Wzz; pfam02706
591020011516	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
591020011517	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
591020011518	active site
591020011519	homodimer interface [polypeptide binding]; other site
591020011520	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
591020011521	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
591020011522	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
591020011523	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
591020011524	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
591020011525	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
591020011526	NAD binding site [chemical binding]; other site
591020011527	substrate binding site [chemical binding]; other site
591020011528	homodimer interface [polypeptide binding]; other site
591020011529	active site
591020011530	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
591020011531	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
591020011532	substrate binding site; other site
591020011533	tetramer interface; other site
591020011534	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
591020011535	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
591020011536	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
591020011537	inhibitor-cofactor binding pocket; inhibition site
591020011538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020011539	catalytic residue [active]
591020011540	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
591020011541	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
591020011542	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
591020011543	putative common antigen polymerase; Provisional; Region: PRK02975
591020011544	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
591020011545	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
591020011546	putative transport protein YifK; Provisional; Region: PRK10746
591020011547	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
591020011548	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
591020011549	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020011550	HTH-like domain; Region: HTH_21; pfam13276
591020011551	Integrase core domain; Region: rve; pfam00665
591020011552	Integrase core domain; Region: rve_3; pfam13683
591020011553	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020011554	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020011555	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
591020011556	HemY protein N-terminus; Region: HemY_N; pfam07219
591020011557	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
591020011558	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
591020011559	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
591020011560	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
591020011561	active site
591020011562	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
591020011563	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
591020011564	domain interfaces; other site
591020011565	active site
591020011566	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
591020011567	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
591020011568	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
591020011569	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
591020011570	putative iron binding site [ion binding]; other site
591020011571	hypothetical protein; Provisional; Region: PRK09807
591020011572	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011573	DKNYY family; Region: DKNYY; pfam13644
591020011574	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
591020011575	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
591020011576	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
591020011577	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
591020011578	hypothetical protein; Provisional; Region: PRK10963
591020011579	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
591020011580	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020011581	active site
591020011582	DNA binding site [nucleotide binding]
591020011583	Int/Topo IB signature motif; other site
591020011584	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
591020011585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020011586	motif II; other site
591020011587	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
591020011588	Part of AAA domain; Region: AAA_19; pfam13245
591020011589	Family description; Region: UvrD_C_2; pfam13538
591020011590	Predicted periplasmic protein [Function unknown]; Region: COG3698
591020011591	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
591020011592	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020011593	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020011594	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020011595	Predicted periplasmic protein [Function unknown]; Region: COG3698
591020011596	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
591020011597	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
591020011598	Cl binding site [ion binding]; other site
591020011599	oligomer interface [polypeptide binding]; other site
591020011600	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
591020011601	hypothetical protein; Provisional; Region: PRK11371
591020011602	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
591020011603	EamA-like transporter family; Region: EamA; cl17759
591020011604	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
591020011605	CoenzymeA binding site [chemical binding]; other site
591020011606	subunit interaction site [polypeptide binding]; other site
591020011607	PHB binding site; other site
591020011608	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
591020011609	dimerization interface [polypeptide binding]; other site
591020011610	substrate binding site [chemical binding]; other site
591020011611	active site
591020011612	calcium binding site [ion binding]; other site
591020011613	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
591020011614	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020011615	ATP binding site [chemical binding]; other site
591020011616	putative Mg++ binding site [ion binding]; other site
591020011617	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
591020011618	nucleotide binding region [chemical binding]; other site
591020011619	ATP-binding site [chemical binding]; other site
591020011620	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
591020011621	Helicase and RNase D C-terminal; Region: HRDC; smart00341
591020011622	threonine efflux system; Provisional; Region: PRK10229
591020011623	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
591020011624	lysophospholipase L2; Provisional; Region: PRK10749
591020011625	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591020011626	putative hydrolase; Provisional; Region: PRK10976
591020011627	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020011628	active site
591020011629	motif I; other site
591020011630	motif II; other site
591020011631	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020011632	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
591020011633	EamA-like transporter family; Region: EamA; pfam00892
591020011634	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
591020011635	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020011636	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
591020011637	putative dimerization interface [polypeptide binding]; other site
591020011638	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
591020011639	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
591020011640	THF binding site; other site
591020011641	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
591020011642	substrate binding site [chemical binding]; other site
591020011643	THF binding site; other site
591020011644	zinc-binding site [ion binding]; other site
591020011645	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
591020011646	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
591020011647	uridine phosphorylase; Provisional; Region: PRK11178
591020011648	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
591020011649	DNA recombination protein RmuC; Provisional; Region: PRK10361
591020011650	RmuC family; Region: RmuC; pfam02646
591020011651	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
591020011652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020011653	S-adenosylmethionine binding site [chemical binding]; other site
591020011654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
591020011655	SCP-2 sterol transfer family; Region: SCP2; pfam02036
591020011656	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
591020011657	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
591020011658	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
591020011659	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
591020011660	sec-independent translocase; Provisional; Region: PRK01770
591020011661	sec-independent translocase; Provisional; Region: tatB; PRK00404
591020011662	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
591020011663	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
591020011664	active site
591020011665	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
591020011666	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
591020011667	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
591020011668	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
591020011669	FMN reductase; Validated; Region: fre; PRK08051
591020011670	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
591020011671	FAD binding pocket [chemical binding]; other site
591020011672	FAD binding motif [chemical binding]; other site
591020011673	phosphate binding motif [ion binding]; other site
591020011674	beta-alpha-beta structure motif; other site
591020011675	NAD binding pocket [chemical binding]; other site
591020011676	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
591020011677	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
591020011678	dimer interface [polypeptide binding]; other site
591020011679	active site
591020011680	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
591020011681	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
591020011682	substrate binding site [chemical binding]; other site
591020011683	oxyanion hole (OAH) forming residues; other site
591020011684	trimer interface [polypeptide binding]; other site
591020011685	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
591020011686	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
591020011687	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
591020011688	proline dipeptidase; Provisional; Region: PRK13607
591020011689	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
591020011690	active site
591020011691	hypothetical protein; Provisional; Region: PRK11568
591020011692	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
591020011693	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
591020011694	potassium transporter; Provisional; Region: PRK10750
591020011695	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
591020011696	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
591020011697	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
591020011698	Walker A motif; other site
591020011699	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
591020011700	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
591020011701	GTP binding site; other site
591020011702	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
591020011703	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
591020011704	serine/threonine protein kinase; Provisional; Region: PRK11768
591020011705	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
591020011706	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
591020011707	catalytic residues [active]
591020011708	hinge region; other site
591020011709	alpha helical domain; other site
591020011710	hypothetical protein; Provisional; Region: PRK11367
591020011711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
591020011712	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
591020011713	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
591020011714	putative acyl-acceptor binding pocket; other site
591020011715	DNA polymerase I; Provisional; Region: PRK05755
591020011716	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
591020011717	active site
591020011718	metal binding site 1 [ion binding]; metal-binding site
591020011719	putative 5' ssDNA interaction site; other site
591020011720	metal binding site 3; metal-binding site
591020011721	metal binding site 2 [ion binding]; metal-binding site
591020011722	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
591020011723	putative DNA binding site [nucleotide binding]; other site
591020011724	putative metal binding site [ion binding]; other site
591020011725	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
591020011726	active site
591020011727	catalytic site [active]
591020011728	substrate binding site [chemical binding]; other site
591020011729	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
591020011730	active site
591020011731	DNA binding site [nucleotide binding]
591020011732	catalytic site [active]
591020011733	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
591020011734	G1 box; other site
591020011735	GTP/Mg2+ binding site [chemical binding]; other site
591020011736	Switch I region; other site
591020011737	G2 box; other site
591020011738	G3 box; other site
591020011739	Switch II region; other site
591020011740	G4 box; other site
591020011741	G5 box; other site
591020011742	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
591020011743	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
591020011744	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020011745	FeS/SAM binding site; other site
591020011746	HemN C-terminal domain; Region: HemN_C; pfam06969
591020011747	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
591020011748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020011749	active site
591020011750	phosphorylation site [posttranslational modification]
591020011751	intermolecular recognition site; other site
591020011752	dimerization interface [polypeptide binding]; other site
591020011753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020011754	Walker A motif; other site
591020011755	ATP binding site [chemical binding]; other site
591020011756	Walker B motif; other site
591020011757	arginine finger; other site
591020011758	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591020011759	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
591020011760	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
591020011761	putative active site [active]
591020011762	heme pocket [chemical binding]; other site
591020011763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020011764	dimer interface [polypeptide binding]; other site
591020011765	phosphorylation site [posttranslational modification]
591020011766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020011767	ATP binding site [chemical binding]; other site
591020011768	Mg2+ binding site [ion binding]; other site
591020011769	G-X-G motif; other site
591020011770	glutamine synthetase; Provisional; Region: glnA; PRK09469
591020011771	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
591020011772	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
591020011773	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
591020011774	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
591020011775	G1 box; other site
591020011776	putative GEF interaction site [polypeptide binding]; other site
591020011777	GTP/Mg2+ binding site [chemical binding]; other site
591020011778	Switch I region; other site
591020011779	G2 box; other site
591020011780	G3 box; other site
591020011781	Switch II region; other site
591020011782	G4 box; other site
591020011783	G5 box; other site
591020011784	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
591020011785	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
591020011786	transcriptional regulator protein; Region: phnR; TIGR03337
591020011787	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020011788	DNA-binding site [nucleotide binding]; DNA binding site
591020011789	UTRA domain; Region: UTRA; pfam07702
591020011790	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
591020011791	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011792	putative substrate translocation pore; other site
591020011793	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011794	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
591020011795	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
591020011796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020011797	alpha-glucosidase; Provisional; Region: PRK10426
591020011798	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
591020011799	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
591020011800	putative active site [active]
591020011801	putative catalytic site [active]
591020011802	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
591020011803	active site
591020011804	catalytic residues [active]
591020011805	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
591020011806	dimerization interface [polypeptide binding]; other site
591020011807	putative active cleft [active]
591020011808	Class I aldolases; Region: Aldolase_Class_I; cl17187
591020011809	catalytic residue [active]
591020011810	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
591020011811	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
591020011812	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
591020011813	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
591020011814	substrate binding site [chemical binding]; other site
591020011815	ATP binding site [chemical binding]; other site
591020011816	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
591020011817	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591020011818	putative DNA binding site [nucleotide binding]; other site
591020011819	putative Zn2+ binding site [ion binding]; other site
591020011820	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020011821	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
591020011822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020011823	motif II; other site
591020011824	hypothetical protein; Reviewed; Region: PRK01637
591020011825	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
591020011826	putative active site [active]
591020011827	dimerization interface [polypeptide binding]; other site
591020011828	putative tRNAtyr binding site [nucleotide binding]; other site
591020011829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020011830	Coenzyme A binding pocket [chemical binding]; other site
591020011831	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
591020011832	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011833	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011834	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
591020011835	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
591020011836	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
591020011837	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
591020011838	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
591020011839	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
591020011840	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
591020011841	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
591020011842	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020011843	HTH domain; Region: HTH_11; pfam08279
591020011844	putative peptidase; Provisional; Region: PRK09864
591020011845	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
591020011846	oligomer interface [polypeptide binding]; other site
591020011847	active site
591020011848	metal binding site [ion binding]; metal-binding site
591020011849	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
591020011850	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591020011851	active site
591020011852	P-loop; other site
591020011853	phosphorylation site [posttranslational modification]
591020011854	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
591020011855	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020011856	active site
591020011857	phosphorylation site [posttranslational modification]
591020011858	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
591020011859	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
591020011860	active site
591020011861	intersubunit interface [polypeptide binding]; other site
591020011862	Zn2+ binding site [ion binding]; other site
591020011863	L-rhamnose isomerase; Provisional; Region: PRK01076
591020011864	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
591020011865	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
591020011866	N- and C-terminal domain interface [polypeptide binding]; other site
591020011867	active site
591020011868	putative catalytic site [active]
591020011869	metal binding site [ion binding]; metal-binding site
591020011870	ATP binding site [chemical binding]; other site
591020011871	rhamnulokinase; Provisional; Region: rhaB; PRK10640
591020011872	carbohydrate binding site [chemical binding]; other site
591020011873	transcriptional activator RhaS; Provisional; Region: PRK13503
591020011874	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591020011875	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020011876	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020011877	transcriptional activator RhaR; Provisional; Region: PRK13500
591020011878	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
591020011879	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020011880	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020011881	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
591020011882	superoxide dismutase; Provisional; Region: PRK10925
591020011883	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
591020011884	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
591020011885	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020011886	HTH-like domain; Region: HTH_21; pfam13276
591020011887	Integrase core domain; Region: rve; pfam00665
591020011888	Integrase core domain; Region: rve_3; pfam13683
591020011889	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020011890	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020011891	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
591020011892	MOSC domain; Region: MOSC; pfam03473
591020011893	3-alpha domain; Region: 3-alpha; pfam03475
591020011894	two-component sensor protein; Provisional; Region: cpxA; PRK09470
591020011895	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020011896	dimerization interface [polypeptide binding]; other site
591020011897	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020011898	dimer interface [polypeptide binding]; other site
591020011899	phosphorylation site [posttranslational modification]
591020011900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020011901	ATP binding site [chemical binding]; other site
591020011902	Mg2+ binding site [ion binding]; other site
591020011903	G-X-G motif; other site
591020011904	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
591020011905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020011906	active site
591020011907	intermolecular recognition site; other site
591020011908	dimerization interface [polypeptide binding]; other site
591020011909	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020011910	DNA binding site [nucleotide binding]
591020011911	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
591020011912	dimer interface [polypeptide binding]; other site
591020011913	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
591020011914	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
591020011915	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
591020011916	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
591020011917	active site
591020011918	ADP/pyrophosphate binding site [chemical binding]; other site
591020011919	dimerization interface [polypeptide binding]; other site
591020011920	allosteric effector site; other site
591020011921	fructose-1,6-bisphosphate binding site; other site
591020011922	sulfate transporter subunit; Provisional; Region: PRK10752
591020011923	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
591020011924	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
591020011925	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
591020011926	triosephosphate isomerase; Provisional; Region: PRK14567
591020011927	substrate binding site [chemical binding]; other site
591020011928	dimer interface [polypeptide binding]; other site
591020011929	catalytic triad [active]
591020011930	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
591020011931	hypothetical protein; Provisional; Region: PRK09981
591020011932	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
591020011933	Ligand Binding Site [chemical binding]; other site
591020011934	ferredoxin-NADP reductase; Provisional; Region: PRK10926
591020011935	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
591020011936	FAD binding pocket [chemical binding]; other site
591020011937	FAD binding motif [chemical binding]; other site
591020011938	phosphate binding motif [ion binding]; other site
591020011939	beta-alpha-beta structure motif; other site
591020011940	NAD binding pocket [chemical binding]; other site
591020011941	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
591020011942	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
591020011943	putative active site [active]
591020011944	glycerol kinase; Provisional; Region: glpK; PRK00047
591020011945	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
591020011946	N- and C-terminal domain interface [polypeptide binding]; other site
591020011947	homotetramer interface [polypeptide binding]; other site
591020011948	homodimer interface [polypeptide binding]; other site
591020011949	active site
591020011950	glycerol binding site [chemical binding]; other site
591020011951	FBP binding site [chemical binding]; other site
591020011952	MgATP binding site [chemical binding]; other site
591020011953	protein IIAGlc interface [polypeptide binding]; other site
591020011954	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
591020011955	amphipathic channel; other site
591020011956	Asn-Pro-Ala signature motifs; other site
591020011957	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
591020011958	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
591020011959	UbiA prenyltransferase family; Region: UbiA; pfam01040
591020011960	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
591020011961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020011962	Walker A motif; other site
591020011963	ATP binding site [chemical binding]; other site
591020011964	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
591020011965	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
591020011966	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
591020011967	active site
591020011968	HslU subunit interaction site [polypeptide binding]; other site
591020011969	essential cell division protein FtsN; Provisional; Region: PRK10927
591020011970	cell division protein FtsN; Provisional; Region: PRK12757
591020011971	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020011972	DNA binding site [nucleotide binding]
591020011973	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
591020011974	domain linker motif; other site
591020011975	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
591020011976	dimerization interface [polypeptide binding]; other site
591020011977	ligand binding site [chemical binding]; other site
591020011978	primosome assembly protein PriA; Validated; Region: PRK05580
591020011979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020011980	ATP binding site [chemical binding]; other site
591020011981	putative Mg++ binding site [ion binding]; other site
591020011982	helicase superfamily c-terminal domain; Region: HELICc; smart00490
591020011983	ATP-binding site [chemical binding]; other site
591020011984	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
591020011985	hypothetical protein; Provisional; Region: PRK10030
591020011986	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
591020011987	dimerization interface [polypeptide binding]; other site
591020011988	DNA binding site [nucleotide binding]
591020011989	corepressor binding sites; other site
591020011990	cystathionine gamma-synthase; Provisional; Region: PRK08045
591020011991	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
591020011992	homodimer interface [polypeptide binding]; other site
591020011993	substrate-cofactor binding pocket; other site
591020011994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020011995	catalytic residue [active]
591020011996	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
591020011997	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
591020011998	putative catalytic residues [active]
591020011999	putative nucleotide binding site [chemical binding]; other site
591020012000	putative aspartate binding site [chemical binding]; other site
591020012001	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
591020012002	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
591020012003	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
591020012004	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
591020012005	FAD binding site [chemical binding]; other site
591020012006	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
591020012007	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
591020012008	heme binding site [chemical binding]; other site
591020012009	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
591020012010	EamA-like transporter family; Region: EamA; pfam00892
591020012011	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
591020012012	EamA-like transporter family; Region: EamA; pfam00892
591020012013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
591020012014	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
591020012015	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591020012016	active site
591020012017	P-loop; other site
591020012018	phosphorylation site [posttranslational modification]
591020012019	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
591020012020	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
591020012021	dimer interface [polypeptide binding]; other site
591020012022	active site
591020012023	glycine loop; other site
591020012024	pyruvate formate lyase II activase; Provisional; Region: PRK10076
591020012025	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
591020012026	active site
591020012027	P-loop; other site
591020012028	phosphorylation site [posttranslational modification]
591020012029	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591020012030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020012031	hypothetical protein; Provisional; Region: PRK10649
591020012032	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
591020012033	Sulfatase; Region: Sulfatase; pfam00884
591020012034	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
591020012035	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
591020012036	acetylornithine deacetylase; Provisional; Region: PRK05111
591020012037	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
591020012038	metal binding site [ion binding]; metal-binding site
591020012039	putative dimer interface [polypeptide binding]; other site
591020012040	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
591020012041	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
591020012042	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
591020012043	nucleotide binding site [chemical binding]; other site
591020012044	N-acetyl-L-glutamate binding site [chemical binding]; other site
591020012045	argininosuccinate lyase; Provisional; Region: PRK04833
591020012046	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
591020012047	active sites [active]
591020012048	tetramer interface [polypeptide binding]; other site
591020012049	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020012050	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020012051	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020012052	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
591020012053	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
591020012054	putative active site pocket [active]
591020012055	putative metal binding site [ion binding]; other site
591020012056	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012057	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
591020012058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020012059	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
591020012060	dimerization interface [polypeptide binding]; other site
591020012061	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
591020012062	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
591020012063	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
591020012064	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
591020012065	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020012066	hypothetical protein; Provisional; Region: PRK11056
591020012067	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
591020012068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020012069	S-adenosylmethionine binding site [chemical binding]; other site
591020012070	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
591020012071	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
591020012072	N-terminal plug; other site
591020012073	ligand-binding site [chemical binding]; other site
591020012074	glutamate racemase; Provisional; Region: PRK00865
591020012075	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
591020012076	FAD binding domain; Region: FAD_binding_4; pfam01565
591020012077	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
591020012078	Biotin operon repressor [Transcription]; Region: BirA; COG1654
591020012079	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
591020012080	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
591020012081	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
591020012082	pantothenate kinase; Provisional; Region: PRK05439
591020012083	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
591020012084	ATP-binding site [chemical binding]; other site
591020012085	CoA-binding site [chemical binding]; other site
591020012086	Mg2+-binding site [ion binding]; other site
591020012087	elongation factor Tu; Reviewed; Region: PRK00049
591020012088	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
591020012089	G1 box; other site
591020012090	GEF interaction site [polypeptide binding]; other site
591020012091	GTP/Mg2+ binding site [chemical binding]; other site
591020012092	Switch I region; other site
591020012093	G2 box; other site
591020012094	G3 box; other site
591020012095	Switch II region; other site
591020012096	G4 box; other site
591020012097	G5 box; other site
591020012098	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
591020012099	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
591020012100	Antibiotic Binding Site [chemical binding]; other site
591020012101	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
591020012102	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
591020012103	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
591020012104	putative homodimer interface [polypeptide binding]; other site
591020012105	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
591020012106	heterodimer interface [polypeptide binding]; other site
591020012107	homodimer interface [polypeptide binding]; other site
591020012108	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
591020012109	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
591020012110	23S rRNA interface [nucleotide binding]; other site
591020012111	L7/L12 interface [polypeptide binding]; other site
591020012112	putative thiostrepton binding site; other site
591020012113	L25 interface [polypeptide binding]; other site
591020012114	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
591020012115	mRNA/rRNA interface [nucleotide binding]; other site
591020012116	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
591020012117	23S rRNA interface [nucleotide binding]; other site
591020012118	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
591020012119	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
591020012120	core dimer interface [polypeptide binding]; other site
591020012121	peripheral dimer interface [polypeptide binding]; other site
591020012122	L10 interface [polypeptide binding]; other site
591020012123	L11 interface [polypeptide binding]; other site
591020012124	putative EF-Tu interaction site [polypeptide binding]; other site
591020012125	putative EF-G interaction site [polypeptide binding]; other site
591020012126	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
591020012127	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
591020012128	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
591020012129	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
591020012130	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
591020012131	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
591020012132	RPB3 interaction site [polypeptide binding]; other site
591020012133	RPB1 interaction site [polypeptide binding]; other site
591020012134	RPB11 interaction site [polypeptide binding]; other site
591020012135	RPB10 interaction site [polypeptide binding]; other site
591020012136	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
591020012137	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
591020012138	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
591020012139	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
591020012140	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
591020012141	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
591020012142	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
591020012143	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
591020012144	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
591020012145	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
591020012146	DNA binding site [nucleotide binding]
591020012147	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
591020012148	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
591020012149	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020012150	FeS/SAM binding site; other site
591020012151	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
591020012152	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
591020012153	ThiS interaction site; other site
591020012154	putative active site [active]
591020012155	tetramer interface [polypeptide binding]; other site
591020012156	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
591020012157	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
591020012158	ATP binding site [chemical binding]; other site
591020012159	substrate interface [chemical binding]; other site
591020012160	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
591020012161	thiamine phosphate binding site [chemical binding]; other site
591020012162	active site
591020012163	pyrophosphate binding site [ion binding]; other site
591020012164	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
591020012165	ThiC-associated domain; Region: ThiC-associated; pfam13667
591020012166	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
591020012167	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
591020012168	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
591020012169	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
591020012170	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
591020012171	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
591020012172	putative NADH binding site [chemical binding]; other site
591020012173	putative active site [active]
591020012174	nudix motif; other site
591020012175	putative metal binding site [ion binding]; other site
591020012176	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
591020012177	Active_site [active]
591020012178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
591020012179	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
591020012180	IHF dimer interface [polypeptide binding]; other site
591020012181	IHF - DNA interface [nucleotide binding]; other site
591020012182	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
591020012183	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
591020012184	dimer interface [polypeptide binding]; other site
591020012185	sensor protein ZraS; Provisional; Region: PRK10364
591020012186	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020012187	dimer interface [polypeptide binding]; other site
591020012188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020012189	ATP binding site [chemical binding]; other site
591020012190	Mg2+ binding site [ion binding]; other site
591020012191	G-X-G motif; other site
591020012192	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
591020012193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020012194	active site
591020012195	phosphorylation site [posttranslational modification]
591020012196	intermolecular recognition site; other site
591020012197	dimerization interface [polypeptide binding]; other site
591020012198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020012199	Walker A motif; other site
591020012200	ATP binding site [chemical binding]; other site
591020012201	Walker B motif; other site
591020012202	arginine finger; other site
591020012203	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
591020012204	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
591020012205	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
591020012206	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
591020012207	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
591020012208	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
591020012209	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
591020012210	purine monophosphate binding site [chemical binding]; other site
591020012211	dimer interface [polypeptide binding]; other site
591020012212	putative catalytic residues [active]
591020012213	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
591020012214	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
591020012215	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020012216	Coenzyme A binding pocket [chemical binding]; other site
591020012217	homoserine O-succinyltransferase; Provisional; Region: PRK05368
591020012218	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
591020012219	proposed active site lysine [active]
591020012220	conserved cys residue [active]
591020012221	isocitrate lyase; Provisional; Region: PRK15063
591020012222	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
591020012223	tetramer interface [polypeptide binding]; other site
591020012224	active site
591020012225	Mg2+/Mn2+ binding site [ion binding]; other site
591020012226	ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906
591020012227	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
591020012228	transcriptional repressor IclR; Provisional; Region: PRK11569
591020012229	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
591020012230	Bacterial transcriptional regulator; Region: IclR; pfam01614
591020012231	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
591020012232	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
591020012233	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
591020012234	substrate binding pocket [chemical binding]; other site
591020012235	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
591020012236	B12 binding site [chemical binding]; other site
591020012237	cobalt ligand [ion binding]; other site
591020012238	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
591020012239	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
591020012240	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
591020012241	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
591020012242	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
591020012243	active site pocket [active]
591020012244	oxyanion hole [active]
591020012245	catalytic triad [active]
591020012246	active site nucleophile [active]
591020012247	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
591020012248	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591020012249	putative NAD(P) binding site [chemical binding]; other site
591020012250	catalytic Zn binding site [ion binding]; other site
591020012251	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
591020012252	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
591020012253	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
591020012254	active site
591020012255	phosphorylation site [posttranslational modification]
591020012256	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
591020012257	active pocket/dimerization site; other site
591020012258	active site
591020012259	phosphorylation site [posttranslational modification]
591020012260	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
591020012261	classical (c) SDRs; Region: SDR_c; cd05233
591020012262	NAD(P) binding site [chemical binding]; other site
591020012263	active site
591020012264	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
591020012265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
591020012266	putative DNA binding site [nucleotide binding]; other site
591020012267	putative Zn2+ binding site [ion binding]; other site
591020012268	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
591020012269	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
591020012270	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
591020012271	RNA binding surface [nucleotide binding]; other site
591020012272	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
591020012273	probable active site [active]
591020012274	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020012275	HTH-like domain; Region: HTH_21; pfam13276
591020012276	Integrase core domain; Region: rve; pfam00665
591020012277	Integrase core domain; Region: rve_3; pfam13683
591020012278	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020012279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020012280	sensory histidine kinase DcuS; Provisional; Region: PRK11086
591020012281	PAS domain; Region: PAS; smart00091
591020012282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020012283	ATP binding site [chemical binding]; other site
591020012284	Mg2+ binding site [ion binding]; other site
591020012285	G-X-G motif; other site
591020012286	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
591020012287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020012288	active site
591020012289	phosphorylation site [posttranslational modification]
591020012290	intermolecular recognition site; other site
591020012291	dimerization interface [polypeptide binding]; other site
591020012292	Transcriptional regulator; Region: CitT; pfam12431
591020012293	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
591020012294	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
591020012295	fumarate hydratase; Provisional; Region: PRK15389
591020012296	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
591020012297	Fumarase C-terminus; Region: Fumerase_C; pfam05683
591020012298	hypothetical protein; Provisional; Region: PRK09867
591020012299	melibiose:sodium symporter; Provisional; Region: PRK10429
591020012300	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
591020012301	alpha-galactosidase; Provisional; Region: PRK15076
591020012302	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
591020012303	NAD binding site [chemical binding]; other site
591020012304	sugar binding site [chemical binding]; other site
591020012305	divalent metal binding site [ion binding]; other site
591020012306	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
591020012307	dimer interface [polypeptide binding]; other site
591020012308	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
591020012309	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020012310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020012311	arginine decarboxylase; Provisional; Region: PRK15029
591020012312	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
591020012313	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
591020012314	homodimer interface [polypeptide binding]; other site
591020012315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020012316	catalytic residue [active]
591020012317	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
591020012318	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
591020012319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020012320	arginine:agmatin antiporter; Provisional; Region: PRK10644
591020012321	putative metal dependent hydrolase; Provisional; Region: PRK11598
591020012322	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
591020012323	Sulfatase; Region: Sulfatase; pfam00884
591020012324	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
591020012325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020012326	active site
591020012327	phosphorylation site [posttranslational modification]
591020012328	intermolecular recognition site; other site
591020012329	dimerization interface [polypeptide binding]; other site
591020012330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020012331	DNA binding site [nucleotide binding]
591020012332	sensor protein BasS/PmrB; Provisional; Region: PRK10755
591020012333	HAMP domain; Region: HAMP; pfam00672
591020012334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020012335	dimer interface [polypeptide binding]; other site
591020012336	phosphorylation site [posttranslational modification]
591020012337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020012338	ATP binding site [chemical binding]; other site
591020012339	Mg2+ binding site [ion binding]; other site
591020012340	G-X-G motif; other site
591020012341	proline/glycine betaine transporter; Provisional; Region: PRK10642
591020012342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020012343	putative substrate translocation pore; other site
591020012344	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
591020012345	YjcZ-like protein; Region: YjcZ; pfam13990
591020012346	hypothetical protein; Provisional; Region: PRK09866
591020012347	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
591020012348	G1 box; other site
591020012349	GTP/Mg2+ binding site [chemical binding]; other site
591020012350	G2 box; other site
591020012351	Switch I region; other site
591020012352	G3 box; other site
591020012353	Switch II region; other site
591020012354	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
591020012355	G2 box; other site
591020012356	Switch I region; other site
591020012357	G3 box; other site
591020012358	Switch II region; other site
591020012359	G4 box; other site
591020012360	G5 box; other site
591020012361	hypothetical protein; Provisional; Region: PRK10220
591020012362	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
591020012363	PhnA protein; Region: PhnA; pfam03831
591020012364	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
591020012365	dimer interface [polypeptide binding]; other site
591020012366	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
591020012367	phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984
591020012368	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
591020012369	Walker A/P-loop; other site
591020012370	ATP binding site [chemical binding]; other site
591020012371	Q-loop/lid; other site
591020012372	ABC transporter signature motif; other site
591020012373	Walker B; other site
591020012374	D-loop; other site
591020012375	H-loop/switch region; other site
591020012376	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
591020012377	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
591020012378	substrate binding pocket [chemical binding]; other site
591020012379	membrane-bound complex binding site; other site
591020012380	hinge residues; other site
591020012381	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
591020012382	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012383	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
591020012384	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020012385	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
591020012386	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
591020012387	DNA binding residues [nucleotide binding]
591020012388	dimer interface [polypeptide binding]; other site
591020012389	[2Fe-2S] cluster binding site [ion binding]; other site
591020012390	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
591020012391	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
591020012392	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
591020012393	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
591020012394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
591020012395	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
591020012396	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
591020012397	Na binding site [ion binding]; other site
591020012398	Predicted membrane protein [Function unknown]; Region: COG3162
591020012399	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
591020012400	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
591020012401	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
591020012402	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
591020012403	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
591020012404	heme lyase subunit NrfE; Provisional; Region: PRK10369
591020012405	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
591020012406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
591020012407	binding surface
591020012408	TPR motif; other site
591020012409	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
591020012410	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
591020012411	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
591020012412	Sel1-like repeats; Region: SEL1; smart00671
591020012413	putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915
591020012414	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
591020012415	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
591020012416	multidrug resistance protein MdtN; Provisional; Region: PRK10476
591020012417	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
591020012418	HlyD family secretion protein; Region: HlyD_3; pfam13437
591020012419	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012420	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
591020012421	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
591020012422	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
591020012423	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
591020012424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
591020012425	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
591020012426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020012427	active site
591020012428	motif I; other site
591020012429	motif II; other site
591020012430	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
591020012431	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
591020012432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
591020012433	homodimer interface [polypeptide binding]; other site
591020012434	catalytic residue [active]
591020012435	alanine racemase; Reviewed; Region: alr; PRK00053
591020012436	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
591020012437	active site
591020012438	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
591020012439	substrate binding site [chemical binding]; other site
591020012440	catalytic residues [active]
591020012441	dimer interface [polypeptide binding]; other site
591020012442	replicative DNA helicase; Provisional; Region: PRK08006
591020012443	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
591020012444	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
591020012445	Walker A motif; other site
591020012446	ATP binding site [chemical binding]; other site
591020012447	Walker B motif; other site
591020012448	DNA binding loops [nucleotide binding]
591020012449	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
591020012450	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
591020012451	NADP binding site [chemical binding]; other site
591020012452	dimer interface [polypeptide binding]; other site
591020012453	phage shock protein G; Reviewed; Region: pspG; PRK09459
591020012454	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
591020012455	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
591020012456	FMN binding site [chemical binding]; other site
591020012457	active site
591020012458	catalytic residues [active]
591020012459	substrate binding site [chemical binding]; other site
591020012460	Protein of unknown function (DUF2713); Region: DUF2713; pfam10897
591020012461	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
591020012462	metal binding site 2 [ion binding]; metal-binding site
591020012463	putative DNA binding helix; other site
591020012464	metal binding site 1 [ion binding]; metal-binding site
591020012465	dimer interface [polypeptide binding]; other site
591020012466	structural Zn2+ binding site [ion binding]; other site
591020012467	hypothetical protein; Provisional; Region: PRK10428
591020012468	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
591020012469	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
591020012470	LexA repressor; Validated; Region: PRK00215
591020012471	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
591020012472	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
591020012473	Catalytic site [active]
591020012474	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
591020012475	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
591020012476	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
591020012477	putative acyl-acceptor binding pocket; other site
591020012478	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
591020012479	UbiA prenyltransferase family; Region: UbiA; pfam01040
591020012480	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
591020012481	maltose regulon periplasmic protein; Provisional; Region: PRK10564
591020012482	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
591020012483	trimer interface; other site
591020012484	sugar binding site [chemical binding]; other site
591020012485	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
591020012486	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
591020012487	Walker A/P-loop; other site
591020012488	ATP binding site [chemical binding]; other site
591020012489	Q-loop/lid; other site
591020012490	ABC transporter signature motif; other site
591020012491	Walker B; other site
591020012492	D-loop; other site
591020012493	H-loop/switch region; other site
591020012494	TOBE domain; Region: TOBE_2; pfam08402
591020012495	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
591020012496	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
591020012497	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
591020012498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020012499	dimer interface [polypeptide binding]; other site
591020012500	conserved gate region; other site
591020012501	putative PBP binding loops; other site
591020012502	ABC-ATPase subunit interface; other site
591020012503	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
591020012504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
591020012505	dimer interface [polypeptide binding]; other site
591020012506	conserved gate region; other site
591020012507	putative PBP binding loops; other site
591020012508	ABC-ATPase subunit interface; other site
591020012509	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
591020012510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020012511	putative substrate translocation pore; other site
591020012512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020012513	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
591020012514	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
591020012515	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
591020012516	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
591020012517	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
591020012518	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
591020012519	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
591020012520	active site
591020012521	dimer interface [polypeptide binding]; other site
591020012522	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
591020012523	dimer interface [polypeptide binding]; other site
591020012524	active site
591020012525	aspartate kinase III; Validated; Region: PRK09084
591020012526	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
591020012527	nucleotide binding site [chemical binding]; other site
591020012528	substrate binding site [chemical binding]; other site
591020012529	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
591020012530	lysine allosteric regulatory site; other site
591020012531	dimer interface [polypeptide binding]; other site
591020012532	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
591020012533	dimer interface [polypeptide binding]; other site
591020012534	putative transposase OrfB; Reviewed; Region: PHA02517
591020012535	Integrase core domain; Region: rve; pfam00665
591020012536	Integrase core domain; Region: rve_3; pfam13683
591020012537	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
591020012538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020012539	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
591020012540	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
591020012541	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
591020012542	Homeodomain-like domain; Region: HTH_23; pfam13384
591020012543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020012544	Transposase; Region: HTH_Tnp_1; pfam01527
591020012545	IS2 repressor TnpA; Reviewed; Region: PRK09413
591020012546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020012547	IS2 transposase TnpB; Reviewed; Region: PRK09409
591020012548	HTH-like domain; Region: HTH_21; pfam13276
591020012549	Integrase core domain; Region: rve; pfam00665
591020012550	Integrase core domain; Region: rve_3; pfam13683
591020012551	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
591020012552	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
591020012553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
591020012554	Nucleoside recognition; Region: Gate; pfam07670
591020012555	hypothetical protein; Provisional; Region: PRK10519
591020012556	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
591020012557	isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975
591020012558	dimer interface [polypeptide binding]; other site
591020012559	active site
591020012560	cell density-dependent motility repressor; Provisional; Region: PRK10082
591020012561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
591020012562	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
591020012563	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
591020012564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
591020012565	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
591020012566	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
591020012567	Protein of unknown function (DUF2686); Region: DUF2686; pfam10887
591020012568	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
591020012569	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020012570	DNA-binding site [nucleotide binding]; DNA binding site
591020012571	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591020012572	D-mannonate oxidoreductase; Provisional; Region: PRK15037
591020012573	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
591020012574	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
591020012575	mannonate dehydratase; Region: uxuA; TIGR00695
591020012576	fructuronate transporter; Provisional; Region: PRK10034
591020012577	gluconate transporter; Region: gntP; TIGR00791
591020012578	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
591020012579	mannosyl binding site [chemical binding]; other site
591020012580	Fimbrial protein; Region: Fimbrial; pfam00419
591020012581	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591020012582	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
591020012583	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
591020012584	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
591020012585	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
591020012586	Fimbrial protein; Region: Fimbrial; cl01416
591020012587	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
591020012588	Int/Topo IB signature motif; other site
591020012589	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
591020012590	active site
591020012591	Int/Topo IB signature motif; other site
591020012592	DNA binding site [nucleotide binding]
591020012593	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
591020012594	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
591020012595	Kelch motif; Region: Kelch_1; pfam01344
591020012596	Domain of unknown function (DUF303); Region: DUF303; pfam03629
591020012597	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012598	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020012599	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020012600	Transposase; Region: HTH_Tnp_1; pfam01527
591020012601	putative transposase OrfB; Reviewed; Region: PHA02517
591020012602	Integrase core domain; Region: rve; pfam00665
591020012603	Integrase core domain; Region: rve_3; pfam13683
591020012604	putative transposase OrfB; Reviewed; Region: PHA02517
591020012605	HTH-like domain; Region: HTH_21; pfam13276
591020012606	Integrase core domain; Region: rve; pfam00665
591020012607	Integrase core domain; Region: rve_2; pfam13333
591020012608	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012609	Integrase core domain; Region: rve; pfam00665
591020012610	Integrase core domain; Region: rve_3; pfam13683
591020012611	integrase; Provisional; Region: PRK09692
591020012612	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
591020012613	active site
591020012614	Int/Topo IB signature motif; other site
591020012615	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
591020012616	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
591020012617	putative NAD(P) binding site [chemical binding]; other site
591020012618	putative substrate binding site [chemical binding]; other site
591020012619	catalytic Zn binding site [ion binding]; other site
591020012620	structural Zn binding site [ion binding]; other site
591020012621	dimer interface [polypeptide binding]; other site
591020012622	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
591020012623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
591020012624	Walker A motif; other site
591020012625	ATP binding site [chemical binding]; other site
591020012626	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
591020012627	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591020012628	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
591020012629	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
591020012630	multifunctional aminopeptidase A; Provisional; Region: PRK00913
591020012631	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
591020012632	interface (dimer of trimers) [polypeptide binding]; other site
591020012633	Substrate-binding/catalytic site; other site
591020012634	Zn-binding sites [ion binding]; other site
591020012635	DNA polymerase III subunit chi; Validated; Region: PRK05728
591020012636	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
591020012637	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
591020012638	HIGH motif; other site
591020012639	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
591020012640	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
591020012641	active site
591020012642	KMSKS motif; other site
591020012643	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
591020012644	tRNA binding surface [nucleotide binding]; other site
591020012645	anticodon binding site; other site
591020012646	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
591020012647	Predicted membrane protein [Function unknown]; Region: COG4269
591020012648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020012649	Coenzyme A binding pocket [chemical binding]; other site
591020012650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
591020012651	RNase E inhibitor protein; Provisional; Region: PRK11191
591020012652	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
591020012653	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591020012654	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591020012655	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012656	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
591020012657	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591020012658	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020012659	oxidoreductase; Provisional; Region: PRK12742
591020012660	classical (c) SDRs; Region: SDR_c; cd05233
591020012661	NAD(P) binding site [chemical binding]; other site
591020012662	active site
591020012663	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
591020012664	homotrimer interaction site [polypeptide binding]; other site
591020012665	putative active site [active]
591020012666	pyrBI operon leader peptide; Provisional; Region: PRK10224
591020012667	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
591020012668	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
591020012669	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
591020012670	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
591020012671	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
591020012672	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
591020012673	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
591020012674	homotrimer interaction site [polypeptide binding]; other site
591020012675	putative active site [active]
591020012676	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
591020012677	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
591020012678	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
591020012679	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
591020012680	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020012681	motif II; other site
591020012682	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
591020012683	trehalose repressor; Provisional; Region: treR; PRK09492
591020012684	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
591020012685	DNA binding site [nucleotide binding]
591020012686	domain linker motif; other site
591020012687	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
591020012688	dimerization interface [polypeptide binding]; other site
591020012689	ligand binding site [chemical binding]; other site
591020012690	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
591020012691	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
591020012692	Ca binding site [ion binding]; other site
591020012693	active site
591020012694	catalytic site [active]
591020012695	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
591020012696	ATP cone domain; Region: ATP-cone; pfam03477
591020012697	Class III ribonucleotide reductase; Region: RNR_III; cd01675
591020012698	effector binding site; other site
591020012699	active site
591020012700	Zn binding site [ion binding]; other site
591020012701	glycine loop; other site
591020012702	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
591020012703	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020012704	FeS/SAM binding site; other site
591020012705	peptidase PmbA; Provisional; Region: PRK11040
591020012706	hypothetical protein; Provisional; Region: PRK05255
591020012707	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
591020012708	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
591020012709	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
591020012710	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
591020012711	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
591020012712	AMP binding site [chemical binding]; other site
591020012713	metal binding site [ion binding]; metal-binding site
591020012714	active site
591020012715	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
591020012716	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
591020012717	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
591020012718	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
591020012719	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
591020012720	TM-ABC transporter signature motif; other site
591020012721	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
591020012722	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
591020012723	Walker A/P-loop; other site
591020012724	ATP binding site [chemical binding]; other site
591020012725	Q-loop/lid; other site
591020012726	ABC transporter signature motif; other site
591020012727	Walker B; other site
591020012728	D-loop; other site
591020012729	H-loop/switch region; other site
591020012730	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
591020012731	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
591020012732	dimer interface [polypeptide binding]; other site
591020012733	substrate binding site [chemical binding]; other site
591020012734	metal binding sites [ion binding]; metal-binding site
591020012735	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
591020012736	putative active site pocket [active]
591020012737	dimerization interface [polypeptide binding]; other site
591020012738	putative catalytic residue [active]
591020012739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
591020012740	Family of unknown function (DUF490); Region: DUF490; pfam04357
591020012741	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
591020012742	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
591020012743	Surface antigen; Region: Bac_surface_Ag; pfam01103
591020012744	methionine sulfoxide reductase A; Provisional; Region: PRK00058
591020012745	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
591020012746	Domain of unknown function DUF21; Region: DUF21; pfam01595
591020012747	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
591020012748	Transporter associated domain; Region: CorC_HlyC; smart01091
591020012749	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
591020012750	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
591020012751	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
591020012752	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
591020012753	active site
591020012754	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
591020012755	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
591020012756	active site
591020012757	metal binding site [ion binding]; metal-binding site
591020012758	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
591020012759	Predicted transcriptional regulators [Transcription]; Region: COG1733
591020012760	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
591020012761	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
591020012762	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
591020012763	NADP binding site [chemical binding]; other site
591020012764	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
591020012765	EamA-like transporter family; Region: EamA; pfam00892
591020012766	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
591020012767	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
591020012768	Hemerythrin-like domain; Region: Hr-like; cd12108
591020012769	Fe binding site [ion binding]; other site
591020012770	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
591020012771	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
591020012772	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
591020012773	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
591020012774	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
591020012775	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
591020012776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
591020012777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020012778	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
591020012779	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337
591020012780	putative NAD(P) binding site [chemical binding]; other site
591020012781	active site
591020012782	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
591020012783	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012784	Integrase core domain; Region: rve_3; pfam13683
591020012785	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
591020012786	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012787	putative transcriptional regulator; Provisional; Region: PRK11640
591020012788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
591020012789	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
591020012790	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
591020012791	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
591020012792	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
591020012793	DsbD alpha interface [polypeptide binding]; other site
591020012794	catalytic residues [active]
591020012795	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
591020012796	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
591020012797	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
591020012798	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
591020012799	Aspartase; Region: Aspartase; cd01357
591020012800	active sites [active]
591020012801	tetramer interface [polypeptide binding]; other site
591020012802	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
591020012803	putative transporter; Provisional; Region: PRK11021
591020012804	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
591020012805	oligomerisation interface [polypeptide binding]; other site
591020012806	mobile loop; other site
591020012807	roof hairpin; other site
591020012808	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
591020012809	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
591020012810	ring oligomerisation interface [polypeptide binding]; other site
591020012811	ATP/Mg binding site [chemical binding]; other site
591020012812	stacking interactions; other site
591020012813	hinge regions; other site
591020012814	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
591020012815	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012816	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
591020012817	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020012818	FeS/SAM binding site; other site
591020012819	elongation factor P; Validated; Region: PRK00529
591020012820	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
591020012821	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
591020012822	RNA binding site [nucleotide binding]; other site
591020012823	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
591020012824	RNA binding site [nucleotide binding]; other site
591020012825	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
591020012826	multidrug efflux system protein; Provisional; Region: PRK11431
591020012827	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
591020012828	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
591020012829	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
591020012830	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
591020012831	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
591020012832	Iron-sulfur protein interface; other site
591020012833	proximal quinone binding site [chemical binding]; other site
591020012834	C-subunit interface; other site
591020012835	distal quinone binding site; other site
591020012836	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
591020012837	D-subunit interface [polypeptide binding]; other site
591020012838	Iron-sulfur protein interface; other site
591020012839	proximal quinone binding site [chemical binding]; other site
591020012840	distal quinone binding site [chemical binding]; other site
591020012841	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
591020012842	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
591020012843	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
591020012844	L-aspartate oxidase; Provisional; Region: PRK06175
591020012845	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
591020012846	poxB regulator PoxA; Provisional; Region: PRK09350
591020012847	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
591020012848	motif 1; other site
591020012849	dimer interface [polypeptide binding]; other site
591020012850	active site
591020012851	motif 2; other site
591020012852	motif 3; other site
591020012853	putative mechanosensitive channel protein; Provisional; Region: PRK10929
591020012854	linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073
591020012855	DNA-binding site [nucleotide binding]; DNA binding site
591020012856	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
591020012857	Mechanosensitive ion channel; Region: MS_channel; pfam00924
591020012858	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
591020012859	GTPase RsgA; Reviewed; Region: PRK12288
591020012860	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
591020012861	RNA binding site [nucleotide binding]; other site
591020012862	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
591020012863	GTPase/Zn-binding domain interface [polypeptide binding]; other site
591020012864	GTP/Mg2+ binding site [chemical binding]; other site
591020012865	G4 box; other site
591020012866	G5 box; other site
591020012867	G1 box; other site
591020012868	Switch I region; other site
591020012869	G2 box; other site
591020012870	G3 box; other site
591020012871	Switch II region; other site
591020012872	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
591020012873	catalytic site [active]
591020012874	putative active site [active]
591020012875	putative substrate binding site [chemical binding]; other site
591020012876	dimer interface [polypeptide binding]; other site
591020012877	epoxyqueuosine reductase; Region: TIGR00276
591020012878	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
591020012879	putative carbohydrate kinase; Provisional; Region: PRK10565
591020012880	yjeF N-terminal region; Region: yjeF_nterm; TIGR00197
591020012881	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
591020012882	putative substrate binding site [chemical binding]; other site
591020012883	putative ATP binding site [chemical binding]; other site
591020012884	ADP-binding protein; Provisional; Region: PRK10646
591020012885	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
591020012886	AMIN domain; Region: AMIN; pfam11741
591020012887	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
591020012888	active site
591020012889	metal binding site [ion binding]; metal-binding site
591020012890	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
591020012891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020012892	ATP binding site [chemical binding]; other site
591020012893	Mg2+ binding site [ion binding]; other site
591020012894	G-X-G motif; other site
591020012895	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
591020012896	ATP binding site [chemical binding]; other site
591020012897	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
591020012898	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
591020012899	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
591020012900	bacterial Hfq-like; Region: Hfq; cd01716
591020012901	hexamer interface [polypeptide binding]; other site
591020012902	Sm1 motif; other site
591020012903	RNA binding site [nucleotide binding]; other site
591020012904	Sm2 motif; other site
591020012905	GTPase HflX; Provisional; Region: PRK11058
591020012906	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
591020012907	HflX GTPase family; Region: HflX; cd01878
591020012908	G1 box; other site
591020012909	GTP/Mg2+ binding site [chemical binding]; other site
591020012910	Switch I region; other site
591020012911	G2 box; other site
591020012912	G3 box; other site
591020012913	Switch II region; other site
591020012914	G4 box; other site
591020012915	G5 box; other site
591020012916	FtsH protease regulator HflK; Provisional; Region: PRK10930
591020012917	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
591020012918	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
591020012919	FtsH protease regulator HflC; Provisional; Region: PRK11029
591020012920	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
591020012921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
591020012922	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
591020012923	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
591020012924	GDP-binding site [chemical binding]; other site
591020012925	ACT binding site; other site
591020012926	IMP binding site; other site
591020012927	Predicted transcriptional regulator [Transcription]; Region: COG1959
591020012928	transcriptional repressor NsrR; Provisional; Region: PRK11014
591020012929	exoribonuclease R; Provisional; Region: PRK11642
591020012930	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
591020012931	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
591020012932	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
591020012933	RNB domain; Region: RNB; pfam00773
591020012934	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
591020012935	RNA binding site [nucleotide binding]; other site
591020012936	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
591020012937	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
591020012938	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
591020012939	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012940	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
591020012941	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
591020012942	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
591020012943	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020012944	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591020012945	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
591020012946	esterase; Provisional; Region: PRK10566
591020012947	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
591020012948	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
591020012949	transcriptional repressor UlaR; Provisional; Region: PRK13509
591020012950	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
591020012951	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
591020012952	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
591020012953	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
591020012954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
591020012955	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
591020012956	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
591020012957	active site
591020012958	P-loop; other site
591020012959	phosphorylation site [posttranslational modification]
591020012960	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
591020012961	active site
591020012962	phosphorylation site [posttranslational modification]
591020012963	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
591020012964	active site
591020012965	dimer interface [polypeptide binding]; other site
591020012966	magnesium binding site [ion binding]; other site
591020012967	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
591020012968	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
591020012969	AP (apurinic/apyrimidinic) site pocket; other site
591020012970	DNA interaction; other site
591020012971	Metal-binding active site; metal-binding site
591020012972	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
591020012973	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
591020012974	intersubunit interface [polypeptide binding]; other site
591020012975	active site
591020012976	Zn2+ binding site [ion binding]; other site
591020012977	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
591020012978	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
591020012979	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
591020012980	dimer interface [polypeptide binding]; other site
591020012981	ssDNA binding site [nucleotide binding]; other site
591020012982	tetramer (dimer of dimers) interface [polypeptide binding]; other site
591020012983	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
591020012984	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
591020012985	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
591020012986	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
591020012987	Protein of unknown function (DUF2686); Region: DUF2686; pfam10887
591020012988	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
591020012989	Transposase; Region: HTH_Tnp_1; pfam01527
591020012990	HTH-like domain; Region: HTH_21; pfam13276
591020012991	Integrase core domain; Region: rve; pfam00665
591020012992	putative transposase OrfB; Reviewed; Region: PHA02517
591020012993	Integrase core domain; Region: rve; pfam00665
591020012994	Integrase core domain; Region: rve_3; pfam13683
591020012995	Uncharacterized conserved protein [Function unknown]; Region: COG3586
591020012996	endoribonuclease SymE; Provisional; Region: PRK13605
591020012997	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
591020012998	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
591020012999	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
591020013000	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
591020013001	HsdM N-terminal domain; Region: HsdM_N; pfam12161
591020013002	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
591020013003	Methyltransferase domain; Region: Methyltransf_26; pfam13659
591020013004	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
591020013005	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
591020013006	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
591020013007	ATP binding site [chemical binding]; other site
591020013008	putative Mg++ binding site [ion binding]; other site
591020013009	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020013010	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
591020013011	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
591020013012	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
591020013013	P-loop, Walker A motif; other site
591020013014	Base recognition motif; other site
591020013015	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
591020013016	Uncharacterized small protein [Function unknown]; Region: COG2879
591020013017	carbon starvation protein A; Provisional; Region: PRK15015
591020013018	Carbon starvation protein CstA; Region: CstA; pfam02554
591020013019	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
591020013020	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
591020013021	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
591020013022	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
591020013023	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
591020013024	Cupin domain; Region: Cupin_2; pfam07883
591020013025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020013026	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
591020013027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020013028	putative substrate translocation pore; other site
591020013029	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
591020013030	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
591020013031	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
591020013032	putative substrate binding pocket [chemical binding]; other site
591020013033	trimer interface [polypeptide binding]; other site
591020013034	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
591020013035	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
591020013036	putative active site [active]
591020013037	putative metal binding site [ion binding]; other site
591020013038	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
591020013039	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
591020013040	NAD binding site [chemical binding]; other site
591020013041	catalytic residues [active]
591020013042	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
591020013043	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305
591020013044	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
591020013045	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
591020013046	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
591020013047	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
591020013048	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
591020013049	dimer interface [polypeptide binding]; other site
591020013050	ligand binding site [chemical binding]; other site
591020013051	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020013052	dimerization interface [polypeptide binding]; other site
591020013053	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
591020013054	dimer interface [polypeptide binding]; other site
591020013055	putative CheW interface [polypeptide binding]; other site
591020013056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
591020013057	D-galactonate transporter; Region: 2A0114; TIGR00893
591020013058	putative substrate translocation pore; other site
591020013059	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
591020013060	DNA-binding site [nucleotide binding]; DNA binding site
591020013061	Transcriptional regulators [Transcription]; Region: GntR; COG1802
591020013062	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
591020013063	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
591020013064	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
591020013065	NAD(P) binding site [chemical binding]; other site
591020013066	phosphoglycerol transferase I; Provisional; Region: PRK03776
591020013067	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
591020013068	hypothetical protein; Provisional; Region: PRK11667
591020013069	DNA replication protein DnaC; Validated; Region: PRK07952
591020013070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
591020013071	Walker A motif; other site
591020013072	ATP binding site [chemical binding]; other site
591020013073	Walker B motif; other site
591020013074	primosomal protein DnaI; Provisional; Region: PRK02854
591020013075	hypothetical protein; Provisional; Region: PRK09917
591020013076	Uncharacterized conserved protein [Function unknown]; Region: COG2966
591020013077	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
591020013078	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
591020013079	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
591020013080	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020013081	DNA binding residues [nucleotide binding]
591020013082	dimerization interface [polypeptide binding]; other site
591020013083	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
591020013084	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
591020013085	DNA binding residues [nucleotide binding]
591020013086	dimerization interface [polypeptide binding]; other site
591020013087	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
591020013088	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
591020013089	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
591020013090	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
591020013091	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
591020013092	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
591020013093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
591020013094	S-adenosylmethionine binding site [chemical binding]; other site
591020013095	DNA polymerase III subunit psi; Validated; Region: PRK06856
591020013096	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
591020013097	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
591020013098	Coenzyme A binding pocket [chemical binding]; other site
591020013099	dUMP phosphatase; Provisional; Region: PRK09449
591020013100	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020013101	motif II; other site
591020013102	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
591020013103	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
591020013104	G1 box; other site
591020013105	putative GEF interaction site [polypeptide binding]; other site
591020013106	GTP/Mg2+ binding site [chemical binding]; other site
591020013107	Switch I region; other site
591020013108	G2 box; other site
591020013109	G3 box; other site
591020013110	Switch II region; other site
591020013111	G4 box; other site
591020013112	G5 box; other site
591020013113	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
591020013114	periplasmic protein; Provisional; Region: PRK10568
591020013115	BON domain; Region: BON; pfam04972
591020013116	BON domain; Region: BON; pfam04972
591020013117	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
591020013118	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
591020013119	active site
591020013120	nucleophile elbow; other site
591020013121	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
591020013122	active site
591020013123	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
591020013124	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
591020013125	FeS/SAM binding site; other site
591020013126	hypothetical protein; Provisional; Region: PRK10977
591020013127	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
591020013128	intersubunit interface [polypeptide binding]; other site
591020013129	active site
591020013130	catalytic residue [active]
591020013131	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
591020013132	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
591020013133	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
591020013134	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
591020013135	phosphopentomutase; Provisional; Region: PRK05362
591020013136	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
591020013137	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
591020013138	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
591020013139	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020013140	non-specific DNA binding site [nucleotide binding]; other site
591020013141	salt bridge; other site
591020013142	sequence-specific DNA binding site [nucleotide binding]; other site
591020013143	hypothetical protein; Provisional; Region: PRK11246
591020013144	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
591020013145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
591020013146	motif II; other site
591020013147	DNA repair protein RadA; Region: sms; TIGR00416
591020013148	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
591020013149	Walker A motif/ATP binding site; other site
591020013150	ATP binding site [chemical binding]; other site
591020013151	Walker B motif; other site
591020013152	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
591020013153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
591020013154	non-specific DNA binding site [nucleotide binding]; other site
591020013155	salt bridge; other site
591020013156	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
591020013157	sequence-specific DNA binding site [nucleotide binding]; other site
591020013158	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
591020013159	active site
591020013160	(T/H)XGH motif; other site
591020013161	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
591020013162	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
591020013163	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
591020013164	Walker A/P-loop; other site
591020013165	ATP binding site [chemical binding]; other site
591020013166	Q-loop/lid; other site
591020013167	ABC transporter signature motif; other site
591020013168	Walker B; other site
591020013169	D-loop; other site
591020013170	H-loop/switch region; other site
591020013171	ABC transporter; Region: ABC_tran_2; pfam12848
591020013172	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
591020013173	lytic murein transglycosylase; Provisional; Region: PRK11619
591020013174	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
591020013175	N-acetyl-D-glucosamine binding site [chemical binding]; other site
591020013176	catalytic residue [active]
591020013177	Trp operon repressor; Provisional; Region: PRK01381
591020013178	Protein of unknown function DUF84; Region: NTPase_I-T; cl00866
591020013179	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
591020013180	catalytic core [active]
591020013181	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
591020013182	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
591020013183	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
591020013184	hypothetical protein; Provisional; Region: PRK10756
591020013185	CreA protein; Region: CreA; pfam05981
591020013186	DNA-binding response regulator CreB; Provisional; Region: PRK11083
591020013187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020013188	active site
591020013189	phosphorylation site [posttranslational modification]
591020013190	intermolecular recognition site; other site
591020013191	dimerization interface [polypeptide binding]; other site
591020013192	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020013193	DNA binding site [nucleotide binding]
591020013194	sensory histidine kinase CreC; Provisional; Region: PRK11100
591020013195	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
591020013196	dimerization interface [polypeptide binding]; other site
591020013197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
591020013198	dimer interface [polypeptide binding]; other site
591020013199	phosphorylation site [posttranslational modification]
591020013200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
591020013201	ATP binding site [chemical binding]; other site
591020013202	Mg2+ binding site [ion binding]; other site
591020013203	G-X-G motif; other site
591020013204	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
591020013205	two-component response regulator; Provisional; Region: PRK11173
591020013206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
591020013207	active site
591020013208	phosphorylation site [posttranslational modification]
591020013209	intermolecular recognition site; other site
591020013210	dimerization interface [polypeptide binding]; other site
591020013211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
591020013212	DNA binding site [nucleotide binding]
591020013213	putative RNA methyltransferase; Provisional; Region: PRK10433
591020013214	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
591020013215	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
591020013216	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
591020013217	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
591020013218	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
591020013219	Phosphotransferase enzyme family; Region: APH; pfam01636
591020013220	active site
591020013221	ATP binding site [chemical binding]; other site
591020013222	antibiotic binding site [chemical binding]; other site
591020013223	dihydropteroate synthase; Region: DHPS; TIGR01496
591020013224	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
591020013225	substrate binding pocket [chemical binding]; other site
591020013226	dimer interface [polypeptide binding]; other site
591020013227	inhibitor binding site; inhibition site
591020013228	Rop protein; Region: Rop; pfam01815
591020013229	LPS O-antigen length regulator; Provisional; Region: PRK10381
591020013230	Chain length determinant protein; Region: Wzz; pfam02706
591020013231	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807