-- dump date 20140620_065239 -- class Genbank::misc_feature -- table misc_feature_note -- id note 198215000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 198215000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 198215000003 putative catalytic residues [active] 198215000004 putative nucleotide binding site [chemical binding]; other site 198215000005 putative aspartate binding site [chemical binding]; other site 198215000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 198215000007 dimer interface [polypeptide binding]; other site 198215000008 putative threonine allosteric regulatory site; other site 198215000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 198215000010 putative threonine allosteric regulatory site; other site 198215000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198215000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198215000013 homoserine kinase; Region: thrB; TIGR00191 198215000014 Protein of unknown function; Region: YhfT; pfam10797 198215000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198215000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 198215000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 198215000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215000019 catalytic residue [active] 198215000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 198215000021 hypothetical protein; Validated; Region: PRK02101 198215000022 transaldolase-like protein; Provisional; Region: PTZ00411 198215000023 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 198215000024 active site 198215000025 dimer interface [polypeptide binding]; other site 198215000026 catalytic residue [active] 198215000027 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 198215000028 MPT binding site; other site 198215000029 trimer interface [polypeptide binding]; other site 198215000030 hypothetical protein; Provisional; Region: PRK10659 198215000031 hypothetical protein; Provisional; Region: PRK10236 198215000032 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 198215000033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 198215000034 hypothetical protein; Provisional; Region: PRK10154 198215000035 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 198215000036 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 198215000037 nucleotide binding site [chemical binding]; other site 198215000038 NEF interaction site [polypeptide binding]; other site 198215000039 SBD interface [polypeptide binding]; other site 198215000040 chaperone protein DnaJ; Provisional; Region: PRK10767 198215000041 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198215000042 HSP70 interaction site [polypeptide binding]; other site 198215000043 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 198215000044 substrate binding site [polypeptide binding]; other site 198215000045 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 198215000046 Zn binding sites [ion binding]; other site 198215000047 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 198215000048 dimer interface [polypeptide binding]; other site 198215000049 Hok/gef family; Region: HOK_GEF; pfam01848 198215000050 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 198215000051 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 198215000052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215000053 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 198215000054 putative dimerization interface [polypeptide binding]; other site 198215000055 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215000056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215000057 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215000058 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215000059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 198215000060 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 198215000061 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 198215000062 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 198215000063 active site 198215000064 Riboflavin kinase; Region: Flavokinase; smart00904 198215000065 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 198215000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 198215000067 HIGH motif; other site 198215000068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 198215000069 active site 198215000070 KMSKS motif; other site 198215000071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 198215000072 tRNA binding surface [nucleotide binding]; other site 198215000073 anticodon binding site; other site 198215000074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198215000075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 198215000076 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 198215000077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198215000078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 198215000079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 198215000080 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198215000081 active site 198215000082 tetramer interface [polypeptide binding]; other site 198215000083 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 198215000084 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 198215000085 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 198215000086 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 198215000087 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 198215000088 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 198215000089 catalytic site [active] 198215000090 subunit interface [polypeptide binding]; other site 198215000091 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 198215000092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198215000093 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198215000094 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 198215000095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198215000096 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198215000097 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 198215000098 IMP binding site; other site 198215000099 dimer interface [polypeptide binding]; other site 198215000100 interdomain contacts; other site 198215000101 partial ornithine binding site; other site 198215000102 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 198215000103 carnitine operon protein CaiE; Provisional; Region: PRK13627 198215000104 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 198215000105 putative trimer interface [polypeptide binding]; other site 198215000106 putative metal binding site [ion binding]; other site 198215000107 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 198215000108 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198215000109 substrate binding site [chemical binding]; other site 198215000110 oxyanion hole (OAH) forming residues; other site 198215000111 trimer interface [polypeptide binding]; other site 198215000112 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 198215000113 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 198215000114 acyl-activating enzyme (AAE) consensus motif; other site 198215000115 putative AMP binding site [chemical binding]; other site 198215000116 putative active site [active] 198215000117 putative CoA binding site [chemical binding]; other site 198215000118 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 198215000119 CoA-transferase family III; Region: CoA_transf_3; pfam02515 198215000120 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 198215000121 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 198215000122 active site 198215000123 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 198215000124 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 198215000125 Ligand binding site [chemical binding]; other site 198215000126 Electron transfer flavoprotein domain; Region: ETF; pfam01012 198215000127 putative oxidoreductase FixC; Provisional; Region: PRK10157 198215000128 ferredoxin-like protein FixX; Provisional; Region: PRK15449 198215000129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215000130 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 198215000131 putative substrate translocation pore; other site 198215000132 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 198215000133 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 198215000134 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 198215000135 TrkA-N domain; Region: TrkA_N; pfam02254 198215000136 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 198215000137 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 198215000138 folate binding site [chemical binding]; other site 198215000139 NADP+ binding site [chemical binding]; other site 198215000140 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 198215000141 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 198215000142 active site 198215000143 metal binding site [ion binding]; metal-binding site 198215000144 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 198215000145 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 198215000146 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 198215000147 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 198215000148 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 198215000149 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 198215000150 SurA N-terminal domain; Region: SurA_N; pfam09312 198215000151 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198215000152 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198215000153 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 198215000154 OstA-like protein; Region: OstA; pfam03968 198215000155 Organic solvent tolerance protein; Region: OstA_C; pfam04453 198215000156 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 198215000157 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 198215000158 putative metal binding site [ion binding]; other site 198215000159 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198215000160 HSP70 interaction site [polypeptide binding]; other site 198215000161 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198215000162 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198215000163 active site 198215000164 ATP-dependent helicase HepA; Validated; Region: PRK04914 198215000165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215000166 ATP binding site [chemical binding]; other site 198215000167 putative Mg++ binding site [ion binding]; other site 198215000168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215000169 nucleotide binding region [chemical binding]; other site 198215000170 ATP-binding site [chemical binding]; other site 198215000171 DNA polymerase II; Reviewed; Region: PRK05762 198215000172 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 198215000173 active site 198215000174 catalytic site [active] 198215000175 substrate binding site [chemical binding]; other site 198215000176 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 198215000177 active site 198215000178 metal-binding site 198215000179 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 198215000180 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198215000181 intersubunit interface [polypeptide binding]; other site 198215000182 active site 198215000183 Zn2+ binding site [ion binding]; other site 198215000184 L-arabinose isomerase; Provisional; Region: PRK02929 198215000185 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 198215000186 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 198215000187 trimer interface [polypeptide binding]; other site 198215000188 putative substrate binding site [chemical binding]; other site 198215000189 putative metal binding site [ion binding]; other site 198215000190 ribulokinase; Provisional; Region: PRK04123 198215000191 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 198215000192 N- and C-terminal domain interface [polypeptide binding]; other site 198215000193 active site 198215000194 MgATP binding site [chemical binding]; other site 198215000195 catalytic site [active] 198215000196 metal binding site [ion binding]; metal-binding site 198215000197 carbohydrate binding site [chemical binding]; other site 198215000198 homodimer interface [polypeptide binding]; other site 198215000199 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 198215000200 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198215000201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215000202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215000203 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198215000204 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 198215000205 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 198215000206 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 198215000207 Walker A/P-loop; other site 198215000208 ATP binding site [chemical binding]; other site 198215000209 Q-loop/lid; other site 198215000210 ABC transporter signature motif; other site 198215000211 Walker B; other site 198215000212 D-loop; other site 198215000213 H-loop/switch region; other site 198215000214 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 198215000215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215000216 dimer interface [polypeptide binding]; other site 198215000217 conserved gate region; other site 198215000218 putative PBP binding loops; other site 198215000219 ABC-ATPase subunit interface; other site 198215000220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215000221 dimer interface [polypeptide binding]; other site 198215000222 conserved gate region; other site 198215000223 putative PBP binding loops; other site 198215000224 ABC-ATPase subunit interface; other site 198215000225 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 198215000226 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 198215000227 transcriptional regulator SgrR; Provisional; Region: PRK13626 198215000228 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 198215000229 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 198215000230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215000231 sugar efflux transporter; Region: 2A0120; TIGR00899 198215000232 putative substrate translocation pore; other site 198215000233 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 198215000234 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 198215000235 substrate binding site [chemical binding]; other site 198215000236 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 198215000237 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 198215000238 substrate binding site [chemical binding]; other site 198215000239 ligand binding site [chemical binding]; other site 198215000240 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 198215000241 tartrate dehydrogenase; Region: TTC; TIGR02089 198215000242 2-isopropylmalate synthase; Validated; Region: PRK00915 198215000243 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 198215000244 active site 198215000245 catalytic residues [active] 198215000246 metal binding site [ion binding]; metal-binding site 198215000247 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 198215000248 leu operon leader peptide; Provisional; Region: PRK09925 198215000249 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 198215000250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215000251 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 198215000252 putative substrate binding pocket [chemical binding]; other site 198215000253 putative dimerization interface [polypeptide binding]; other site 198215000254 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 198215000255 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198215000256 PYR/PP interface [polypeptide binding]; other site 198215000257 dimer interface [polypeptide binding]; other site 198215000258 TPP binding site [chemical binding]; other site 198215000259 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198215000260 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198215000261 TPP-binding site [chemical binding]; other site 198215000262 dimer interface [polypeptide binding]; other site 198215000263 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 198215000264 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 198215000265 putative valine binding site [chemical binding]; other site 198215000266 dimer interface [polypeptide binding]; other site 198215000267 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 198215000268 similar to fruR leader peptide; residues 1 to 28 of 28 are 100.00 pct identical to residues 1 to 28 of 28 from Escherichia coli K-12 : B0079 198215000269 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 198215000270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215000271 DNA binding site [nucleotide binding] 198215000272 domain linker motif; other site 198215000273 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 198215000274 dimerization interface [polypeptide binding]; other site 198215000275 ligand binding site [chemical binding]; other site 198215000276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215000277 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215000278 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215000279 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215000280 mraZ protein; Region: TIGR00242 198215000281 MraZ protein; Region: MraZ; pfam02381 198215000282 MraZ protein; Region: MraZ; pfam02381 198215000283 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 198215000284 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 198215000285 cell division protein FtsL; Provisional; Region: PRK10772 198215000286 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 198215000287 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 198215000288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198215000289 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 198215000290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198215000291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198215000292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198215000293 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 198215000294 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198215000295 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198215000296 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198215000297 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 198215000298 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 198215000299 Mg++ binding site [ion binding]; other site 198215000300 putative catalytic motif [active] 198215000301 putative substrate binding site [chemical binding]; other site 198215000302 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 198215000303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198215000304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198215000305 cell division protein FtsW; Provisional; Region: PRK10774 198215000306 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 198215000307 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 198215000308 active site 198215000309 homodimer interface [polypeptide binding]; other site 198215000310 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 198215000311 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198215000312 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198215000313 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198215000314 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 198215000315 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 198215000316 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 198215000317 cell division protein FtsQ; Provisional; Region: PRK10775 198215000318 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 198215000319 Cell division protein FtsQ; Region: FtsQ; pfam03799 198215000320 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 198215000321 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198215000322 Cell division protein FtsA; Region: FtsA; pfam14450 198215000323 cell division protein FtsZ; Validated; Region: PRK09330 198215000324 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 198215000325 nucleotide binding site [chemical binding]; other site 198215000326 SulA interaction site; other site 198215000327 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 198215000328 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 198215000329 SecA regulator SecM; Provisional; Region: PRK02943 198215000330 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 198215000331 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 198215000332 SEC-C motif; Region: SEC-C; pfam02810 198215000333 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 198215000334 active site 198215000335 8-oxo-dGMP binding site [chemical binding]; other site 198215000336 nudix motif; other site 198215000337 metal binding site [ion binding]; metal-binding site 198215000338 DNA gyrase inhibitor; Reviewed; Region: PRK00418 198215000339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 198215000340 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 198215000341 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 198215000342 CoA-binding site [chemical binding]; other site 198215000343 ATP-binding [chemical binding]; other site 198215000344 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 198215000345 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198215000346 active site 198215000347 type IV pilin biogenesis protein; Provisional; Region: PRK10573 198215000348 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198215000349 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198215000350 putative major pilin subunit; Provisional; Region: PRK10574 198215000351 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 198215000352 Pilin (bacterial filament); Region: Pilin; pfam00114 198215000353 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 198215000354 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 198215000355 dimerization interface [polypeptide binding]; other site 198215000356 active site 198215000357 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 198215000358 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198215000359 amidase catalytic site [active] 198215000360 Zn binding residues [ion binding]; other site 198215000361 substrate binding site [chemical binding]; other site 198215000362 regulatory protein AmpE; Provisional; Region: PRK10987 198215000363 aromatic amino acid transporter; Provisional; Region: PRK10238 198215000364 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198215000365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215000366 DNA-binding site [nucleotide binding]; DNA binding site 198215000367 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198215000368 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 198215000369 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 198215000370 dimer interface [polypeptide binding]; other site 198215000371 TPP-binding site [chemical binding]; other site 198215000372 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 198215000373 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198215000374 E3 interaction surface; other site 198215000375 lipoyl attachment site [posttranslational modification]; other site 198215000376 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198215000377 E3 interaction surface; other site 198215000378 lipoyl attachment site [posttranslational modification]; other site 198215000379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198215000380 E3 interaction surface; other site 198215000381 lipoyl attachment site [posttranslational modification]; other site 198215000382 e3 binding domain; Region: E3_binding; pfam02817 198215000383 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198215000384 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 198215000385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198215000386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215000387 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 198215000388 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 198215000389 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 198215000390 substrate binding site [chemical binding]; other site 198215000391 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 198215000392 substrate binding site [chemical binding]; other site 198215000393 ligand binding site [chemical binding]; other site 198215000394 hypothetical protein; Provisional; Region: PRK05248 198215000395 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 198215000396 spermidine synthase; Provisional; Region: PRK00811 198215000397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215000398 S-adenosylmethionine binding site [chemical binding]; other site 198215000399 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 198215000400 multicopper oxidase; Provisional; Region: PRK10965 198215000401 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 198215000402 Multicopper oxidase; Region: Cu-oxidase; pfam00394 198215000403 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 198215000404 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 198215000405 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 198215000406 Trp docking motif [polypeptide binding]; other site 198215000407 putative active site [active] 198215000408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215000409 active site 198215000410 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 198215000411 active site clefts [active] 198215000412 zinc binding site [ion binding]; other site 198215000413 dimer interface [polypeptide binding]; other site 198215000414 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198215000415 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198215000416 Walker A/P-loop; other site 198215000417 ATP binding site [chemical binding]; other site 198215000418 Q-loop/lid; other site 198215000419 ABC transporter signature motif; other site 198215000420 Walker B; other site 198215000421 D-loop; other site 198215000422 H-loop/switch region; other site 198215000423 inner membrane transport permease; Provisional; Region: PRK15066 198215000424 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198215000425 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198215000426 active pocket/dimerization site; other site 198215000427 active site 198215000428 phosphorylation site [posttranslational modification] 198215000429 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 198215000430 putative active site [active] 198215000431 putative metal binding site [ion binding]; other site 198215000432 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 198215000433 tetramerization interface [polypeptide binding]; other site 198215000434 active site 198215000435 Uncharacterized conserved protein [Function unknown]; Region: COG5464 198215000436 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198215000437 pantoate--beta-alanine ligase; Region: panC; TIGR00018 198215000438 Pantoate-beta-alanine ligase; Region: PanC; cd00560 198215000439 active site 198215000440 ATP-binding site [chemical binding]; other site 198215000441 pantoate-binding site; other site 198215000442 HXXH motif; other site 198215000443 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 198215000444 oligomerization interface [polypeptide binding]; other site 198215000445 active site 198215000446 metal binding site [ion binding]; metal-binding site 198215000447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215000448 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215000449 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215000450 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215000451 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 198215000452 catalytic center binding site [active] 198215000453 ATP binding site [chemical binding]; other site 198215000454 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 198215000455 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 198215000456 active site 198215000457 NTP binding site [chemical binding]; other site 198215000458 metal binding triad [ion binding]; metal-binding site 198215000459 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 198215000460 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 198215000461 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 198215000462 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 198215000463 active site 198215000464 nucleotide binding site [chemical binding]; other site 198215000465 HIGH motif; other site 198215000466 KMSKS motif; other site 198215000467 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 198215000468 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 198215000469 2'-5' RNA ligase; Provisional; Region: PRK15124 198215000470 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198215000471 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198215000472 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 198215000473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215000474 ATP binding site [chemical binding]; other site 198215000475 putative Mg++ binding site [ion binding]; other site 198215000476 nucleotide binding region [chemical binding]; other site 198215000477 helicase superfamily c-terminal domain; Region: HELICc; smart00490 198215000478 ATP-binding site [chemical binding]; other site 198215000479 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 198215000480 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 198215000481 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 198215000482 Transglycosylase; Region: Transgly; pfam00912 198215000483 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198215000484 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 198215000485 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198215000486 N-terminal plug; other site 198215000487 ligand-binding site [chemical binding]; other site 198215000488 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 198215000489 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198215000490 Walker A/P-loop; other site 198215000491 ATP binding site [chemical binding]; other site 198215000492 Q-loop/lid; other site 198215000493 ABC transporter signature motif; other site 198215000494 Walker B; other site 198215000495 D-loop; other site 198215000496 H-loop/switch region; other site 198215000497 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198215000498 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198215000499 siderophore binding site; other site 198215000500 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198215000501 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215000502 ABC-ATPase subunit interface; other site 198215000503 dimer interface [polypeptide binding]; other site 198215000504 putative PBP binding regions; other site 198215000505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215000506 ABC-ATPase subunit interface; other site 198215000507 dimer interface [polypeptide binding]; other site 198215000508 putative PBP binding regions; other site 198215000509 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 198215000510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198215000511 inhibitor-cofactor binding pocket; inhibition site 198215000512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215000513 catalytic residue [active] 198215000514 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 198215000515 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 198215000516 Cl- selectivity filter; other site 198215000517 Cl- binding residues [ion binding]; other site 198215000518 pore gating glutamate residue; other site 198215000519 dimer interface [polypeptide binding]; other site 198215000520 H+/Cl- coupling transport residue; other site 198215000521 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 198215000522 hypothetical protein; Provisional; Region: PRK10578 198215000523 UPF0126 domain; Region: UPF0126; pfam03458 198215000524 UPF0126 domain; Region: UPF0126; pfam03458 198215000525 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 198215000526 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 198215000527 cobalamin binding residues [chemical binding]; other site 198215000528 putative BtuC binding residues; other site 198215000529 dimer interface [polypeptide binding]; other site 198215000530 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 198215000531 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 198215000532 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 198215000533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198215000534 Zn2+ binding site [ion binding]; other site 198215000535 Mg2+ binding site [ion binding]; other site 198215000536 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 198215000537 serine endoprotease; Provisional; Region: PRK10942 198215000538 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198215000539 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198215000540 protein binding site [polypeptide binding]; other site 198215000541 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198215000542 hypothetical protein; Provisional; Region: PRK13677 198215000543 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 198215000544 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 198215000545 trimer interface [polypeptide binding]; other site 198215000546 active site 198215000547 substrate binding site [chemical binding]; other site 198215000548 CoA binding site [chemical binding]; other site 198215000549 PII uridylyl-transferase; Provisional; Region: PRK05007 198215000550 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198215000551 metal binding triad; other site 198215000552 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198215000553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198215000554 Zn2+ binding site [ion binding]; other site 198215000555 Mg2+ binding site [ion binding]; other site 198215000556 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 198215000557 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 198215000558 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 198215000559 active site 198215000560 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 198215000561 rRNA interaction site [nucleotide binding]; other site 198215000562 S8 interaction site; other site 198215000563 putative laminin-1 binding site; other site 198215000564 elongation factor Ts; Provisional; Region: tsf; PRK09377 198215000565 UBA/TS-N domain; Region: UBA; pfam00627 198215000566 Elongation factor TS; Region: EF_TS; pfam00889 198215000567 Elongation factor TS; Region: EF_TS; pfam00889 198215000568 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 198215000569 putative nucleotide binding site [chemical binding]; other site 198215000570 uridine monophosphate binding site [chemical binding]; other site 198215000571 homohexameric interface [polypeptide binding]; other site 198215000572 ribosome recycling factor; Reviewed; Region: frr; PRK00083 198215000573 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 198215000574 hinge region; other site 198215000575 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 198215000576 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 198215000577 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 198215000578 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 198215000579 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 198215000580 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 198215000581 catalytic residue [active] 198215000582 putative FPP diphosphate binding site; other site 198215000583 putative FPP binding hydrophobic cleft; other site 198215000584 dimer interface [polypeptide binding]; other site 198215000585 putative IPP diphosphate binding site; other site 198215000586 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 198215000587 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 198215000588 zinc metallopeptidase RseP; Provisional; Region: PRK10779 198215000589 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 198215000590 active site 198215000591 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 198215000592 protein binding site [polypeptide binding]; other site 198215000593 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 198215000594 putative substrate binding region [chemical binding]; other site 198215000595 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 198215000596 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198215000597 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198215000598 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198215000599 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198215000600 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198215000601 Surface antigen; Region: Bac_surface_Ag; pfam01103 198215000602 periplasmic chaperone; Provisional; Region: PRK10780 198215000603 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 198215000604 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 198215000605 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 198215000606 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 198215000607 trimer interface [polypeptide binding]; other site 198215000608 active site 198215000609 UDP-GlcNAc binding site [chemical binding]; other site 198215000610 lipid binding site [chemical binding]; lipid-binding site 198215000611 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 198215000612 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 198215000613 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 198215000614 active site 198215000615 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 198215000616 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 198215000617 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 198215000618 RNA/DNA hybrid binding site [nucleotide binding]; other site 198215000619 active site 198215000620 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 198215000621 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 198215000622 putative active site [active] 198215000623 putative PHP Thumb interface [polypeptide binding]; other site 198215000624 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 198215000625 generic binding surface II; other site 198215000626 generic binding surface I; other site 198215000627 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 198215000628 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 198215000629 lysine decarboxylase LdcC; Provisional; Region: PRK15399 198215000630 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 198215000631 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198215000632 homodimer interface [polypeptide binding]; other site 198215000633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215000634 catalytic residue [active] 198215000635 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198215000636 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 198215000637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198215000638 putative metal binding site [ion binding]; other site 198215000639 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 198215000640 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 198215000641 Ligand Binding Site [chemical binding]; other site 198215000642 TilS substrate binding domain; Region: TilS; pfam09179 198215000643 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 198215000644 Rho-binding antiterminator; Provisional; Region: PRK11625 198215000645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 198215000646 hypothetical protein; Provisional; Region: PRK09256 198215000647 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 198215000648 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 198215000649 NlpE N-terminal domain; Region: NlpE; pfam04170 198215000650 hypothetical protein; Provisional; Region: PRK11479 198215000651 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 198215000652 prolyl-tRNA synthetase; Provisional; Region: PRK09194 198215000653 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 198215000654 dimer interface [polypeptide binding]; other site 198215000655 motif 1; other site 198215000656 active site 198215000657 motif 2; other site 198215000658 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 198215000659 putative deacylase active site [active] 198215000660 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 198215000661 active site 198215000662 motif 3; other site 198215000663 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 198215000664 anticodon binding site; other site 198215000665 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 198215000666 homodimer interaction site [polypeptide binding]; other site 198215000667 cofactor binding site; other site 198215000668 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 198215000669 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 198215000670 lipoprotein, YaeC family; Region: TIGR00363 198215000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215000672 dimer interface [polypeptide binding]; other site 198215000673 conserved gate region; other site 198215000674 ABC-ATPase subunit interface; other site 198215000675 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 198215000676 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198215000677 Walker A/P-loop; other site 198215000678 ATP binding site [chemical binding]; other site 198215000679 Q-loop/lid; other site 198215000680 ABC transporter signature motif; other site 198215000681 Walker B; other site 198215000682 D-loop; other site 198215000683 H-loop/switch region; other site 198215000684 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 198215000685 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 198215000686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215000687 active site 198215000688 motif I; other site 198215000689 motif II; other site 198215000690 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198215000691 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198215000692 active site 198215000693 catalytic tetrad [active] 198215000694 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215000695 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215000696 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215000697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198215000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215000699 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 198215000700 putative effector binding pocket; other site 198215000701 dimerization interface [polypeptide binding]; other site 198215000702 hypothetical protein; Provisional; Region: PRK05421 198215000703 putative catalytic site [active] 198215000704 putative metal binding site [ion binding]; other site 198215000705 putative phosphate binding site [ion binding]; other site 198215000706 putative catalytic site [active] 198215000707 putative phosphate binding site [ion binding]; other site 198215000708 putative metal binding site [ion binding]; other site 198215000709 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198215000710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215000711 S-adenosylmethionine binding site [chemical binding]; other site 198215000712 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 198215000713 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198215000714 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198215000715 catalytic residue [active] 198215000716 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215000717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215000718 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 198215000719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215000720 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 198215000721 RNA/DNA hybrid binding site [nucleotide binding]; other site 198215000722 active site 198215000723 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 198215000724 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 198215000725 active site 198215000726 catalytic site [active] 198215000727 substrate binding site [chemical binding]; other site 198215000728 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 198215000729 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 198215000730 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 198215000731 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 198215000732 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 198215000733 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 198215000734 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 198215000735 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 198215000736 ImpE protein; Region: ImpE; pfam07024 198215000737 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 198215000738 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215000739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000740 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215000741 HTH-like domain; Region: HTH_21; pfam13276 198215000742 Integrase core domain; Region: rve; pfam00665 198215000743 Integrase core domain; Region: rve_3; pfam13683 198215000744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000745 Transposase; Region: HTH_Tnp_1; cl17663 198215000746 putative transposase OrfB; Reviewed; Region: PHA02517 198215000747 HTH-like domain; Region: HTH_21; pfam13276 198215000748 Integrase core domain; Region: rve; pfam00665 198215000749 Integrase core domain; Region: rve_3; pfam13683 198215000750 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 198215000751 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 198215000752 Lysis protein S; Region: Lysis_S; pfam04971 198215000753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000754 putative transposase OrfB; Reviewed; Region: PHA02517 198215000755 HTH-like domain; Region: HTH_21; pfam13276 198215000756 Integrase core domain; Region: rve; pfam00665 198215000757 Integrase core domain; Region: rve_3; pfam13683 198215000758 putative transposase OrfB; Reviewed; Region: PHA02517 198215000759 HTH-like domain; Region: HTH_21; pfam13276 198215000760 Integrase core domain; Region: rve; pfam00665 198215000761 Integrase core domain; Region: rve_3; pfam13683 198215000762 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 198215000763 Terminase-like family; Region: Terminase_6; pfam03237 198215000764 Terminase-like family; Region: Terminase_6; pfam03237 198215000765 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 198215000766 coat protein; Region: PHA01511 198215000767 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 198215000768 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 198215000769 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 198215000770 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 198215000771 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 198215000772 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 198215000773 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 198215000774 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198215000775 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198215000776 catalytic residue [active] 198215000777 Transposase; Region: HTH_Tnp_1; cl17663 198215000778 Integrase core domain; Region: rve; pfam00665 198215000779 Integrase core domain; Region: rve_3; pfam13683 198215000780 hypothetical protein; Provisional; Region: PRK11505 198215000781 psiF repeat; Region: PsiF_repeat; pfam07769 198215000782 psiF repeat; Region: PsiF_repeat; pfam07769 198215000783 alkaline phosphatase; Provisional; Region: PRK10518 198215000784 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 198215000785 dimer interface [polypeptide binding]; other site 198215000786 active site 198215000787 anti-RssB factor; Provisional; Region: PRK10244 198215000788 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 198215000789 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 198215000790 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 198215000791 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 198215000792 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 198215000793 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 198215000794 microcin B17 transporter; Reviewed; Region: PRK11098 198215000795 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 198215000796 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 198215000797 putative transposase OrfB; Reviewed; Region: PHA02517 198215000798 HTH-like domain; Region: HTH_21; pfam13276 198215000799 Integrase core domain; Region: rve; pfam00665 198215000800 Integrase core domain; Region: rve_2; pfam13333 198215000801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215000802 Integrase core domain; Region: rve; pfam00665 198215000803 Integrase core domain; Region: rve_3; pfam13683 198215000804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000805 Transposase; Region: HTH_Tnp_1; pfam01527 198215000806 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215000807 HTH-like domain; Region: HTH_21; pfam13276 198215000808 Integrase core domain; Region: rve; pfam00665 198215000809 Integrase core domain; Region: rve_3; pfam13683 198215000810 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215000811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000812 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 198215000813 dimer interface [polypeptide binding]; other site 198215000814 active site 198215000815 Schiff base residues; other site 198215000816 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 198215000817 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 198215000818 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198215000819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215000820 dimer interface [polypeptide binding]; other site 198215000821 conserved gate region; other site 198215000822 putative PBP binding loops; other site 198215000823 ABC-ATPase subunit interface; other site 198215000824 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 198215000825 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198215000826 Walker A/P-loop; other site 198215000827 ATP binding site [chemical binding]; other site 198215000828 Q-loop/lid; other site 198215000829 ABC transporter signature motif; other site 198215000830 Walker B; other site 198215000831 D-loop; other site 198215000832 H-loop/switch region; other site 198215000833 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 198215000834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215000835 substrate binding pocket [chemical binding]; other site 198215000836 membrane-bound complex binding site; other site 198215000837 hinge residues; other site 198215000838 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215000839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215000840 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215000841 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215000842 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198215000843 Uncharacterized conserved protein [Function unknown]; Region: COG1556 198215000844 iron-sulfur cluster-binding protein; Region: TIGR00273 198215000845 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 198215000846 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198215000847 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 198215000848 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198215000849 Cysteine-rich domain; Region: CCG; pfam02754 198215000850 Cysteine-rich domain; Region: CCG; pfam02754 198215000851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215000852 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215000853 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215000854 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215000855 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 198215000856 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 198215000857 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 198215000858 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 198215000859 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 198215000860 PAAR motif; Region: PAAR_motif; pfam05488 198215000861 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198215000862 RHS Repeat; Region: RHS_repeat; pfam05593 198215000863 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198215000864 RHS protein; Region: RHS; pfam03527 198215000865 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198215000866 C-N hydrolase family amidase; Provisional; Region: PRK10438 198215000867 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 198215000868 putative active site [active] 198215000869 catalytic triad [active] 198215000870 dimer interface [polypeptide binding]; other site 198215000871 multimer interface [polypeptide binding]; other site 198215000872 C-lysozyme inhibitor; Provisional; Region: PRK09993 198215000873 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 198215000874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 198215000875 active site 198215000876 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 198215000877 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 198215000878 dimer interface [polypeptide binding]; other site 198215000879 active site 198215000880 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 198215000881 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 198215000882 putative active site [active] 198215000883 putative dimer interface [polypeptide binding]; other site 198215000884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 198215000885 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198215000886 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198215000887 NlpC/P60 family; Region: NLPC_P60; pfam00877 198215000888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 198215000889 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 198215000890 FHIPEP family; Region: FHIPEP; pfam00771 198215000891 hypothetical protein; Validated; Region: PRK06778 198215000892 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198215000893 ligand binding site [chemical binding]; other site 198215000894 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 198215000895 active site 198215000896 DNA polymerase IV; Validated; Region: PRK02406 198215000897 DNA binding site [nucleotide binding] 198215000898 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 198215000899 putative toxin YafO; Provisional; Region: PRK09885 198215000900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198215000901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215000902 Coenzyme A binding pocket [chemical binding]; other site 198215000903 hypothetical protein; Reviewed; Region: PRK09588 198215000904 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 198215000905 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 198215000906 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 198215000907 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 198215000908 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 198215000909 metal binding site [ion binding]; metal-binding site 198215000910 dimer interface [polypeptide binding]; other site 198215000911 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215000912 active site 198215000913 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 198215000914 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 198215000915 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198215000916 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198215000917 trimer interface [polypeptide binding]; other site 198215000918 eyelet of channel; other site 198215000919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215000920 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215000921 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215000922 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215000923 gamma-glutamyl kinase; Provisional; Region: PRK05429 198215000924 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 198215000925 nucleotide binding site [chemical binding]; other site 198215000926 homotetrameric interface [polypeptide binding]; other site 198215000927 putative phosphate binding site [ion binding]; other site 198215000928 putative allosteric binding site; other site 198215000929 PUA domain; Region: PUA; pfam01472 198215000930 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 198215000931 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 198215000932 putative catalytic cysteine [active] 198215000933 integrase; Provisional; Region: int; PHA02601 198215000934 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 198215000935 Int/Topo IB signature motif; other site 198215000936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000937 Transposase; Region: HTH_Tnp_1; pfam01527 198215000938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215000939 Integrase core domain; Region: rve; pfam00665 198215000940 Integrase core domain; Region: rve_3; pfam13683 198215000941 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198215000942 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 198215000943 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215000944 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 198215000945 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 198215000946 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 198215000947 Ligand binding site; other site 198215000948 Putative Catalytic site; other site 198215000949 DXD motif; other site 198215000950 Predicted membrane protein [Function unknown]; Region: COG2246 198215000951 GtrA-like protein; Region: GtrA; pfam04138 198215000952 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198215000953 DNA binding site [nucleotide binding] 198215000954 active site 198215000955 Int/Topo IB signature motif; other site 198215000956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215000957 Integrase core domain; Region: rve; pfam00665 198215000958 Integrase core domain; Region: rve_3; pfam13683 198215000959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000960 Transposase; Region: HTH_Tnp_1; pfam01527 198215000961 integrase; Provisional; Region: int; PHA02601 198215000962 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 198215000963 Int/Topo IB signature motif; other site 198215000964 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 198215000965 Integrase core domain; Region: rve; pfam00665 198215000966 Integrase core domain; Region: rve_3; pfam13683 198215000967 Integrase core domain; Region: rve; pfam00665 198215000968 Integrase core domain; Region: rve_3; pfam13683 198215000969 Transposase; Region: HTH_Tnp_1; cl17663 198215000970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215000971 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 198215000972 MASE2 domain; Region: MASE2; pfam05230 198215000973 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198215000974 metal binding site [ion binding]; metal-binding site 198215000975 active site 198215000976 I-site; other site 198215000977 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 198215000978 pyrroline-5-carboxylate reductase; Region: PLN02688 198215000979 hypothetical protein; Validated; Region: PRK00124 198215000980 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 198215000981 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 198215000982 ADP binding site [chemical binding]; other site 198215000983 magnesium binding site [ion binding]; other site 198215000984 putative shikimate binding site; other site 198215000985 hypothetical protein; Provisional; Region: PRK10380 198215000986 hypothetical protein; Provisional; Region: PRK10481 198215000987 hypothetical protein; Provisional; Region: PRK10579 198215000988 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 198215000989 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 198215000990 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 198215000991 fructokinase; Reviewed; Region: PRK09557 198215000992 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198215000993 nucleotide binding site [chemical binding]; other site 198215000994 MFS transport protein AraJ; Provisional; Region: PRK10091 198215000995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215000996 putative substrate translocation pore; other site 198215000997 exonuclease subunit SbcC; Provisional; Region: PRK10246 198215000998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215000999 Walker A/P-loop; other site 198215001000 ATP binding site [chemical binding]; other site 198215001001 Q-loop/lid; other site 198215001002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215001003 Q-loop/lid; other site 198215001004 ABC transporter signature motif; other site 198215001005 Walker B; other site 198215001006 D-loop; other site 198215001007 H-loop/switch region; other site 198215001008 exonuclease subunit SbcD; Provisional; Region: PRK10966 198215001009 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 198215001010 active site 198215001011 metal binding site [ion binding]; metal-binding site 198215001012 DNA binding site [nucleotide binding] 198215001013 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 198215001014 transcriptional regulator PhoB; Provisional; Region: PRK10161 198215001015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215001016 active site 198215001017 phosphorylation site [posttranslational modification] 198215001018 intermolecular recognition site; other site 198215001019 dimerization interface [polypeptide binding]; other site 198215001020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215001021 DNA binding site [nucleotide binding] 198215001022 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 198215001023 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 198215001024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198215001025 putative active site [active] 198215001026 heme pocket [chemical binding]; other site 198215001027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215001028 dimer interface [polypeptide binding]; other site 198215001029 phosphorylation site [posttranslational modification] 198215001030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215001031 ATP binding site [chemical binding]; other site 198215001032 Mg2+ binding site [ion binding]; other site 198215001033 G-X-G motif; other site 198215001034 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 198215001035 putative proline-specific permease; Provisional; Region: proY; PRK10580 198215001036 Spore germination protein; Region: Spore_permease; cl17796 198215001037 maltodextrin glucosidase; Provisional; Region: PRK10785 198215001038 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 198215001039 homodimer interface [polypeptide binding]; other site 198215001040 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 198215001041 active site 198215001042 homodimer interface [polypeptide binding]; other site 198215001043 catalytic site [active] 198215001044 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 198215001045 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 198215001046 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 198215001047 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 198215001048 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 198215001049 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 198215001050 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 198215001051 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198215001052 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 198215001053 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 198215001054 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198215001055 Protein export membrane protein; Region: SecD_SecF; pfam02355 198215001056 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198215001057 active site 198215001058 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 198215001059 hypothetical protein; Provisional; Region: PRK11530 198215001060 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 198215001061 ATP cone domain; Region: ATP-cone; pfam03477 198215001062 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 198215001063 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 198215001064 catalytic motif [active] 198215001065 Zn binding site [ion binding]; other site 198215001066 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 198215001067 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 198215001068 homopentamer interface [polypeptide binding]; other site 198215001069 active site 198215001070 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 198215001071 putative RNA binding site [nucleotide binding]; other site 198215001072 thiamine monophosphate kinase; Provisional; Region: PRK05731 198215001073 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 198215001074 ATP binding site [chemical binding]; other site 198215001075 dimerization interface [polypeptide binding]; other site 198215001076 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 198215001077 tetramer interfaces [polypeptide binding]; other site 198215001078 binuclear metal-binding site [ion binding]; other site 198215001079 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 198215001080 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 198215001081 TPP-binding site; other site 198215001082 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198215001083 PYR/PP interface [polypeptide binding]; other site 198215001084 dimer interface [polypeptide binding]; other site 198215001085 TPP binding site [chemical binding]; other site 198215001086 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198215001087 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 198215001088 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198215001089 substrate binding pocket [chemical binding]; other site 198215001090 chain length determination region; other site 198215001091 substrate-Mg2+ binding site; other site 198215001092 catalytic residues [active] 198215001093 aspartate-rich region 1; other site 198215001094 active site lid residues [active] 198215001095 aspartate-rich region 2; other site 198215001096 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 198215001097 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 198215001098 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 198215001099 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 198215001100 Ligand Binding Site [chemical binding]; other site 198215001101 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198215001102 active site residue [active] 198215001103 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 198215001104 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 198215001105 conserved cys residue [active] 198215001106 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 198215001107 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 198215001108 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 198215001109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 198215001110 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 198215001111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 198215001112 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198215001113 Sel1-like repeats; Region: SEL1; smart00671 198215001114 Sel1-like repeats; Region: SEL1; smart00671 198215001115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215001116 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215001117 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215001118 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215001119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 198215001120 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 198215001121 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 198215001122 UbiA prenyltransferase family; Region: UbiA; pfam01040 198215001123 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 198215001124 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 198215001125 Subunit I/III interface [polypeptide binding]; other site 198215001126 Subunit III/IV interface [polypeptide binding]; other site 198215001127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215001128 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215001129 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215001130 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215001131 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215001132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215001133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215001134 Transposase; Region: HTH_Tnp_1; pfam01527 198215001135 muropeptide transporter; Reviewed; Region: ampG; PRK11902 198215001136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215001137 putative substrate translocation pore; other site 198215001138 hypothetical protein; Provisional; Region: PRK11627 198215001139 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 198215001140 transcriptional regulator BolA; Provisional; Region: PRK11628 198215001141 trigger factor; Provisional; Region: tig; PRK01490 198215001142 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198215001143 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 198215001144 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 198215001145 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 198215001146 oligomer interface [polypeptide binding]; other site 198215001147 active site residues [active] 198215001148 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 198215001149 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 198215001150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215001151 Walker A motif; other site 198215001152 ATP binding site [chemical binding]; other site 198215001153 Walker B motif; other site 198215001154 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198215001155 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 198215001156 Found in ATP-dependent protease La (LON); Region: LON; smart00464 198215001157 Found in ATP-dependent protease La (LON); Region: LON; smart00464 198215001158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215001159 Walker A motif; other site 198215001160 ATP binding site [chemical binding]; other site 198215001161 Walker B motif; other site 198215001162 arginine finger; other site 198215001163 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198215001164 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198215001165 IHF dimer interface [polypeptide binding]; other site 198215001166 IHF - DNA interface [nucleotide binding]; other site 198215001167 periplasmic folding chaperone; Provisional; Region: PRK10788 198215001168 SurA N-terminal domain; Region: SurA_N_3; cl07813 198215001169 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 198215001170 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 198215001171 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 198215001172 active site 198215001173 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 198215001174 Ligand Binding Site [chemical binding]; other site 198215001175 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 198215001176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215001177 active site 198215001178 motif I; other site 198215001179 motif II; other site 198215001180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215001181 dimerization interface [polypeptide binding]; other site 198215001182 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198215001183 putative DNA binding site [nucleotide binding]; other site 198215001184 putative Zn2+ binding site [ion binding]; other site 198215001185 AsnC family; Region: AsnC_trans_reg; pfam01037 198215001186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198215001187 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 198215001188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215001189 Walker A/P-loop; other site 198215001190 ATP binding site [chemical binding]; other site 198215001191 Q-loop/lid; other site 198215001192 ABC transporter signature motif; other site 198215001193 Walker B; other site 198215001194 D-loop; other site 198215001195 H-loop/switch region; other site 198215001196 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 198215001197 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198215001198 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 198215001199 Walker A/P-loop; other site 198215001200 ATP binding site [chemical binding]; other site 198215001201 Q-loop/lid; other site 198215001202 ABC transporter signature motif; other site 198215001203 Walker B; other site 198215001204 D-loop; other site 198215001205 H-loop/switch region; other site 198215001206 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 198215001207 Nitrogen regulatory protein P-II; Region: P-II; smart00938 198215001208 ammonium transporter; Provisional; Region: PRK10666 198215001209 acyl-CoA thioesterase II; Provisional; Region: PRK10526 198215001210 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 198215001211 active site 198215001212 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 198215001213 catalytic triad [active] 198215001214 dimer interface [polypeptide binding]; other site 198215001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 198215001216 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215001217 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215001218 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215001219 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 198215001220 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198215001221 DNA binding site [nucleotide binding] 198215001222 active site 198215001223 Uncharacterized conserved protein [Function unknown]; Region: COG5507 198215001224 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 198215001225 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198215001226 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198215001227 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 198215001228 gene expression modulator; Provisional; Region: PRK10945 198215001229 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 198215001230 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 198215001231 Protein export membrane protein; Region: SecD_SecF; cl14618 198215001232 Protein export membrane protein; Region: SecD_SecF; cl14618 198215001233 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 198215001234 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215001235 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 198215001236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215001237 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 198215001238 hypothetical protein; Provisional; Region: PRK11281 198215001239 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 198215001240 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 198215001241 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198215001242 hypothetical protein; Provisional; Region: PRK11038 198215001243 primosomal replication protein N''; Provisional; Region: PRK10093 198215001244 hypothetical protein; Provisional; Region: PRK10527 198215001245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215001246 active site 198215001247 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 198215001248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215001249 Walker A motif; other site 198215001250 ATP binding site [chemical binding]; other site 198215001251 Walker B motif; other site 198215001252 DNA polymerase III subunit delta'; Validated; Region: PRK08485 198215001253 arginine finger; other site 198215001254 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 198215001255 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 198215001256 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 198215001257 hypothetical protein; Validated; Region: PRK00153 198215001258 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 198215001259 RecR protein; Region: RecR; pfam02132 198215001260 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 198215001261 putative active site [active] 198215001262 putative metal-binding site [ion binding]; other site 198215001263 tetramer interface [polypeptide binding]; other site 198215001264 heat shock protein 90; Provisional; Region: PRK05218 198215001265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215001266 ATP binding site [chemical binding]; other site 198215001267 Mg2+ binding site [ion binding]; other site 198215001268 G-X-G motif; other site 198215001269 adenylate kinase; Reviewed; Region: adk; PRK00279 198215001270 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 198215001271 AMP-binding site [chemical binding]; other site 198215001272 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 198215001273 ferrochelatase; Region: hemH; TIGR00109 198215001274 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 198215001275 C-terminal domain interface [polypeptide binding]; other site 198215001276 active site 198215001277 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 198215001278 active site 198215001279 N-terminal domain interface [polypeptide binding]; other site 198215001280 acetyl esterase; Provisional; Region: PRK10162 198215001281 inosine/guanosine kinase; Provisional; Region: PRK15074 198215001282 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215001283 putative cation:proton antiport protein; Provisional; Region: PRK10669 198215001284 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 198215001285 TrkA-N domain; Region: TrkA_N; pfam02254 198215001286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215001287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198215001288 putative substrate translocation pore; other site 198215001289 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 198215001290 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 198215001291 active site 198215001292 metal binding site [ion binding]; metal-binding site 198215001293 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198215001294 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 198215001295 putative deacylase active site [active] 198215001296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 198215001297 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 198215001298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215001299 non-specific DNA binding site [nucleotide binding]; other site 198215001300 salt bridge; other site 198215001301 sequence-specific DNA binding site [nucleotide binding]; other site 198215001302 copper exporting ATPase; Provisional; Region: copA; PRK10671 198215001303 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198215001304 metal-binding site [ion binding] 198215001305 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198215001306 metal-binding site [ion binding] 198215001307 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198215001308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215001309 motif II; other site 198215001310 glutaminase; Reviewed; Region: PRK12356 198215001311 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 198215001312 amino acid transporter; Region: 2A0306; TIGR00909 198215001313 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 198215001314 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 198215001315 DNA binding residues [nucleotide binding] 198215001316 dimer interface [polypeptide binding]; other site 198215001317 copper binding site [ion binding]; other site 198215001318 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 198215001319 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 198215001320 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 198215001321 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 198215001322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215001323 Walker A/P-loop; other site 198215001324 ATP binding site [chemical binding]; other site 198215001325 Q-loop/lid; other site 198215001326 ABC transporter signature motif; other site 198215001327 Walker B; other site 198215001328 D-loop; other site 198215001329 H-loop/switch region; other site 198215001330 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 198215001331 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 198215001332 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 198215001333 oxidoreductase; Provisional; Region: PRK08017 198215001334 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198215001335 NADP binding site [chemical binding]; other site 198215001336 active site 198215001337 steroid binding site; other site 198215001338 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 198215001339 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198215001340 Walker A/P-loop; other site 198215001341 ATP binding site [chemical binding]; other site 198215001342 Q-loop/lid; other site 198215001343 ABC transporter signature motif; other site 198215001344 Walker B; other site 198215001345 D-loop; other site 198215001346 H-loop/switch region; other site 198215001347 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 198215001348 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 198215001349 active site residue [active] 198215001350 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 198215001351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215001352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215001353 dimerization interface [polypeptide binding]; other site 198215001354 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 198215001355 ureidoglycolate hydrolase; Provisional; Region: PRK03606 198215001356 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 198215001357 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198215001358 Bacterial transcriptional regulator; Region: IclR; pfam01614 198215001359 glyoxylate carboligase; Provisional; Region: PRK11269 198215001360 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198215001361 PYR/PP interface [polypeptide binding]; other site 198215001362 dimer interface [polypeptide binding]; other site 198215001363 TPP binding site [chemical binding]; other site 198215001364 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198215001365 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 198215001366 TPP-binding site [chemical binding]; other site 198215001367 hydroxypyruvate isomerase; Provisional; Region: PRK09997 198215001368 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215001369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215001370 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215001371 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215001372 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 198215001373 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 198215001374 allantoate amidohydrolase; Region: AllC; TIGR03176 198215001375 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 198215001376 active site 198215001377 metal binding site [ion binding]; metal-binding site 198215001378 dimer interface [polypeptide binding]; other site 198215001379 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 198215001380 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 198215001381 putative substrate binding site [chemical binding]; other site 198215001382 nucleotide binding site [chemical binding]; other site 198215001383 nucleotide binding site [chemical binding]; other site 198215001384 homodimer interface [polypeptide binding]; other site 198215001385 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 198215001386 ATP-grasp domain; Region: ATP-grasp; pfam02222 198215001387 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 198215001388 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 198215001389 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198215001390 putative active site [active] 198215001391 putative metal binding site [ion binding]; other site 198215001392 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 198215001393 substrate binding site [chemical binding]; other site 198215001394 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 198215001395 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 198215001396 active site 198215001397 HIGH motif; other site 198215001398 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 198215001399 KMSKS motif; other site 198215001400 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 198215001401 tRNA binding surface [nucleotide binding]; other site 198215001402 anticodon binding site; other site 198215001403 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 198215001404 ribosome-associated protein; Provisional; Region: PRK11507 198215001405 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 198215001406 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 198215001407 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 198215001408 homodimer interface [polypeptide binding]; other site 198215001409 NADP binding site [chemical binding]; other site 198215001410 substrate binding site [chemical binding]; other site 198215001411 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 198215001412 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 198215001413 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 198215001414 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 198215001415 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215001416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215001417 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215001418 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215001419 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198215001420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215001421 hypothetical protein; Provisional; Region: PRK09936 198215001422 sensor kinase CusS; Provisional; Region: PRK09835 198215001423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215001424 dimerization interface [polypeptide binding]; other site 198215001425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215001426 dimer interface [polypeptide binding]; other site 198215001427 phosphorylation site [posttranslational modification] 198215001428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215001429 ATP binding site [chemical binding]; other site 198215001430 Mg2+ binding site [ion binding]; other site 198215001431 G-X-G motif; other site 198215001432 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 198215001433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215001434 active site 198215001435 phosphorylation site [posttranslational modification] 198215001436 intermolecular recognition site; other site 198215001437 dimerization interface [polypeptide binding]; other site 198215001438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215001439 DNA binding site [nucleotide binding] 198215001440 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 198215001441 periplasmic copper-binding protein; Provisional; Region: PRK09838 198215001442 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 198215001443 Integrase core domain; Region: rve; pfam00665 198215001444 Integrase core domain; Region: rve_3; pfam13683 198215001445 Transposase; Region: HTH_Tnp_1; cl17663 198215001446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215001447 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 198215001448 HTH-like domain; Region: HTH_21; pfam13276 198215001449 Integrase core domain; Region: rve; pfam00665 198215001450 Integrase core domain; Region: rve_3; pfam13683 198215001451 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215001452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215001453 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 198215001454 phenylalanine transporter; Provisional; Region: PRK10249 198215001455 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 198215001456 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198215001457 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 198215001458 dimer interface [polypeptide binding]; other site 198215001459 FMN binding site [chemical binding]; other site 198215001460 hypothetical protein; Provisional; Region: PRK10250 198215001461 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 198215001462 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 198215001463 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 198215001464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215001465 Helix-turn-helix domain; Region: HTH_28; pfam13518 198215001466 Helix-turn-helix domain; Region: HTH_28; pfam13518 198215001467 HTH-like domain; Region: HTH_21; pfam13276 198215001468 Hok/gef family; Region: HOK_GEF; pfam01848 198215001469 Hok/gef family; Region: HOK_GEF; pfam01848 198215001470 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 198215001471 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 198215001472 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 198215001473 outer membrane receptor FepA; Provisional; Region: PRK13524 198215001474 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198215001475 N-terminal plug; other site 198215001476 ligand-binding site [chemical binding]; other site 198215001477 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 198215001478 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 198215001479 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 198215001480 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 198215001481 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198215001482 acyl-activating enzyme (AAE) consensus motif; other site 198215001483 AMP binding site [chemical binding]; other site 198215001484 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198215001485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215001486 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215001487 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215001488 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215001489 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 198215001490 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198215001491 Walker A/P-loop; other site 198215001492 ATP binding site [chemical binding]; other site 198215001493 Q-loop/lid; other site 198215001494 ABC transporter signature motif; other site 198215001495 Walker B; other site 198215001496 D-loop; other site 198215001497 H-loop/switch region; other site 198215001498 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 198215001499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215001500 ABC-ATPase subunit interface; other site 198215001501 dimer interface [polypeptide binding]; other site 198215001502 putative PBP binding regions; other site 198215001503 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198215001504 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215001505 ABC-ATPase subunit interface; other site 198215001506 dimer interface [polypeptide binding]; other site 198215001507 putative PBP binding regions; other site 198215001508 enterobactin exporter EntS; Provisional; Region: PRK10489 198215001509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215001510 putative substrate translocation pore; other site 198215001511 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 198215001512 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198215001513 siderophore binding site; other site 198215001514 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 198215001515 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 198215001516 acyl-activating enzyme (AAE) consensus motif; other site 198215001517 active site 198215001518 AMP binding site [chemical binding]; other site 198215001519 substrate binding site [chemical binding]; other site 198215001520 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 198215001521 hydrophobic substrate binding pocket; other site 198215001522 Isochorismatase family; Region: Isochorismatase; pfam00857 198215001523 active site 198215001524 conserved cis-peptide bond; other site 198215001525 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 198215001526 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 198215001527 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 198215001528 putative NAD(P) binding site [chemical binding]; other site 198215001529 active site 198215001530 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198215001531 CoenzymeA binding site [chemical binding]; other site 198215001532 subunit interaction site [polypeptide binding]; other site 198215001533 PHB binding site; other site 198215001534 carbon starvation protein A; Provisional; Region: PRK15015 198215001535 Carbon starvation protein CstA; Region: CstA; pfam02554 198215001536 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198215001537 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 198215001538 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 198215001539 putative active site [active] 198215001540 metal binding site [ion binding]; metal-binding site 198215001541 methionine aminotransferase; Validated; Region: PRK09082 198215001542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215001543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215001544 homodimer interface [polypeptide binding]; other site 198215001545 catalytic residue [active] 198215001546 Integrase core domain; Region: rve; pfam00665 198215001547 Integrase core domain; Region: rve_3; pfam13683 198215001548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215001549 Transposase; Region: HTH_Tnp_1; pfam01527 198215001550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215001551 Transposase; Region: HTH_Tnp_1; pfam01527 198215001552 putative transposase OrfB; Reviewed; Region: PHA02517 198215001553 HTH-like domain; Region: HTH_21; pfam13276 198215001554 Integrase core domain; Region: rve; pfam00665 198215001555 Integrase core domain; Region: rve_2; pfam13333 198215001556 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 198215001557 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 198215001558 dimerization domain [polypeptide binding]; other site 198215001559 dimer interface [polypeptide binding]; other site 198215001560 catalytic residues [active] 198215001561 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 198215001562 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 198215001563 dimer interface [polypeptide binding]; other site 198215001564 decamer (pentamer of dimers) interface [polypeptide binding]; other site 198215001565 catalytic triad [active] 198215001566 peroxidatic and resolving cysteines [active] 198215001567 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 198215001568 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 198215001569 catalytic residue [active] 198215001570 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 198215001571 catalytic residues [active] 198215001572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198215001573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215001574 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198215001575 Ligand Binding Site [chemical binding]; other site 198215001576 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 198215001577 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198215001578 NAD binding site [chemical binding]; other site 198215001579 catalytic Zn binding site [ion binding]; other site 198215001580 structural Zn binding site [ion binding]; other site 198215001581 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 198215001582 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198215001583 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 198215001584 B1 nucleotide binding pocket [chemical binding]; other site 198215001585 B2 nucleotide binding pocket [chemical binding]; other site 198215001586 CAS motifs; other site 198215001587 active site 198215001588 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 198215001589 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 198215001590 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 198215001591 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198215001592 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 198215001593 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 198215001594 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 198215001595 putative active site [active] 198215001596 (T/H)XGH motif; other site 198215001597 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215001598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215001599 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215001600 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215001601 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 198215001602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215001603 motif II; other site 198215001604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215001605 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 198215001606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215001607 Walker A/P-loop; other site 198215001608 ATP binding site [chemical binding]; other site 198215001609 Q-loop/lid; other site 198215001610 ABC transporter signature motif; other site 198215001611 Walker B; other site 198215001612 D-loop; other site 198215001613 H-loop/switch region; other site 198215001614 molybdenum-pterin binding domain; Region: Mop; TIGR00638 198215001615 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198215001616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215001617 putative PBP binding loops; other site 198215001618 ABC-ATPase subunit interface; other site 198215001619 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 198215001620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215001621 substrate binding pocket [chemical binding]; other site 198215001622 membrane-bound complex binding site; other site 198215001623 hinge residues; other site 198215001624 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 198215001625 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 198215001626 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 198215001627 molybdenum-pterin binding domain; Region: Mop; TIGR00638 198215001628 TOBE domain; Region: TOBE; pfam03459 198215001629 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 198215001630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 198215001631 Walker A/P-loop; other site 198215001632 ATP binding site [chemical binding]; other site 198215001633 Q-loop/lid; other site 198215001634 ABC transporter signature motif; other site 198215001635 Walker B; other site 198215001636 D-loop; other site 198215001637 H-loop/switch region; other site 198215001638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215001639 Walker A/P-loop; other site 198215001640 ATP binding site [chemical binding]; other site 198215001641 Q-loop/lid; other site 198215001642 ABC transporter signature motif; other site 198215001643 Walker B; other site 198215001644 D-loop; other site 198215001645 H-loop/switch region; other site 198215001646 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 198215001647 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 198215001648 NAD binding site [chemical binding]; other site 198215001649 homodimer interface [polypeptide binding]; other site 198215001650 active site 198215001651 substrate binding site [chemical binding]; other site 198215001652 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 198215001653 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 198215001654 dimer interface [polypeptide binding]; other site 198215001655 active site 198215001656 galactokinase; Provisional; Region: PRK05101 198215001657 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 198215001658 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198215001659 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 198215001660 active site 198215001661 catalytic residues [active] 198215001662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198215001663 catalytic core [active] 198215001664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198215001665 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 198215001666 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198215001667 YbgS-like protein; Region: YbgS; pfam13985 198215001668 zinc transporter ZitB; Provisional; Region: PRK03557 198215001669 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 198215001670 quinolinate synthetase; Provisional; Region: PRK09375 198215001671 tol-pal system protein YbgF; Provisional; Region: PRK10803 198215001672 Tetratricopeptide repeat; Region: TPR_6; pfam13174 198215001673 Tetratricopeptide repeat; Region: TPR_6; pfam13174 198215001674 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 198215001675 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198215001676 ligand binding site [chemical binding]; other site 198215001677 translocation protein TolB; Provisional; Region: tolB; PRK03629 198215001678 TolB amino-terminal domain; Region: TolB_N; pfam04052 198215001679 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198215001680 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198215001681 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198215001682 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 198215001683 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 198215001684 TolA C-terminal; Region: TolA; pfam06519 198215001685 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 198215001686 colicin uptake protein TolR; Provisional; Region: PRK11024 198215001687 colicin uptake protein TolQ; Provisional; Region: PRK10801 198215001688 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 198215001689 active site 198215001690 hypothetical protein; Provisional; Region: PRK10588 198215001691 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 198215001692 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 198215001693 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 198215001694 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 198215001695 alpha-mannosidase; Provisional; Region: PRK09819 198215001696 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 198215001697 active site 198215001698 metal binding site [ion binding]; metal-binding site 198215001699 catalytic site [active] 198215001700 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 198215001701 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 198215001702 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215001703 active site 198215001704 phosphorylation site [posttranslational modification] 198215001705 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198215001706 active site 198215001707 P-loop; other site 198215001708 phosphorylation site [posttranslational modification] 198215001709 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 198215001710 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 198215001711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215001712 DNA-binding site [nucleotide binding]; DNA binding site 198215001713 UTRA domain; Region: UTRA; pfam07702 198215001714 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 198215001715 CoA binding domain; Region: CoA_binding; smart00881 198215001716 CoA-ligase; Region: Ligase_CoA; pfam00549 198215001717 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 198215001718 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 198215001719 CoA-ligase; Region: Ligase_CoA; pfam00549 198215001720 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 198215001721 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198215001722 E3 interaction surface; other site 198215001723 lipoyl attachment site [posttranslational modification]; other site 198215001724 e3 binding domain; Region: E3_binding; pfam02817 198215001725 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198215001726 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 198215001727 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 198215001728 TPP-binding site [chemical binding]; other site 198215001729 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 198215001730 dimer interface [polypeptide binding]; other site 198215001731 PYR/PP interface [polypeptide binding]; other site 198215001732 TPP binding site [chemical binding]; other site 198215001733 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 198215001734 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 198215001735 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 198215001736 L-aspartate oxidase; Provisional; Region: PRK06175 198215001737 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198215001738 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 198215001739 SdhC subunit interface [polypeptide binding]; other site 198215001740 proximal heme binding site [chemical binding]; other site 198215001741 cardiolipin binding site; other site 198215001742 Iron-sulfur protein interface; other site 198215001743 proximal quinone binding site [chemical binding]; other site 198215001744 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 198215001745 Iron-sulfur protein interface; other site 198215001746 proximal quinone binding site [chemical binding]; other site 198215001747 SdhD (CybS) interface [polypeptide binding]; other site 198215001748 proximal heme binding site [chemical binding]; other site 198215001749 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 198215001750 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 198215001751 dimer interface [polypeptide binding]; other site 198215001752 active site 198215001753 citrylCoA binding site [chemical binding]; other site 198215001754 NADH binding [chemical binding]; other site 198215001755 cationic pore residues; other site 198215001756 oxalacetate/citrate binding site [chemical binding]; other site 198215001757 coenzyme A binding site [chemical binding]; other site 198215001758 catalytic triad [active] 198215001759 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198215001760 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 198215001761 PapC N-terminal domain; Region: PapC_N; pfam13954 198215001762 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 198215001763 PapC C-terminal domain; Region: PapC_C; pfam13953 198215001764 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 198215001765 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 198215001766 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 198215001767 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 198215001768 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 198215001769 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 198215001770 endonuclease VIII; Provisional; Region: PRK10445 198215001771 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 198215001772 DNA binding site [nucleotide binding] 198215001773 catalytic residue [active] 198215001774 putative catalytic residues [active] 198215001775 H2TH interface [polypeptide binding]; other site 198215001776 intercalation triad [nucleotide binding]; other site 198215001777 substrate specificity determining residue; other site 198215001778 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198215001779 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198215001780 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 198215001781 putative active site [active] 198215001782 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 198215001783 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 198215001784 Uncharacterized conserved protein [Function unknown]; Region: COG0327 198215001785 metal-binding protein; Provisional; Region: PRK10799 198215001786 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 198215001787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215001788 putative substrate translocation pore; other site 198215001789 POT family; Region: PTR2; pfam00854 198215001790 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 198215001791 DNA photolyase; Region: DNA_photolyase; pfam00875 198215001792 hypothetical protein; Provisional; Region: PRK10167 198215001793 Uncharacterized conserved protein [Function unknown]; Region: COG3272 198215001794 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 198215001795 PAAR motif; Region: PAAR_motif; pfam05488 198215001796 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198215001797 RHS Repeat; Region: RHS_repeat; cl11982 198215001798 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 198215001799 RHS Repeat; Region: RHS_repeat; cl11982 198215001800 RHS Repeat; Region: RHS_repeat; pfam05593 198215001801 RHS Repeat; Region: RHS_repeat; cl11982 198215001802 RHS protein; Region: RHS; pfam03527 198215001803 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198215001804 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215001805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215001806 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215001807 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215001808 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 198215001809 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 198215001810 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 198215001811 putrescine transporter; Provisional; Region: potE; PRK10655 198215001812 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 198215001813 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 198215001814 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 198215001815 active site 198215001816 substrate binding site [chemical binding]; other site 198215001817 metal binding site [ion binding]; metal-binding site 198215001818 replication initiation regulator SeqA; Provisional; Region: PRK11187 198215001819 acyl-CoA esterase; Provisional; Region: PRK10673 198215001820 PGAP1-like protein; Region: PGAP1; pfam07819 198215001821 LexA regulated protein; Provisional; Region: PRK11675 198215001822 flavodoxin FldA; Validated; Region: PRK09267 198215001823 ferric uptake regulator; Provisional; Region: fur; PRK09462 198215001824 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198215001825 metal binding site 2 [ion binding]; metal-binding site 198215001826 putative DNA binding helix; other site 198215001827 metal binding site 1 [ion binding]; metal-binding site 198215001828 dimer interface [polypeptide binding]; other site 198215001829 structural Zn2+ binding site [ion binding]; other site 198215001830 YbfN-like lipoprotein; Region: YbfN; pfam13982 198215001831 outer membrane porin, OprD family; Region: OprD; pfam03573 198215001832 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 198215001833 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 198215001834 active site 198215001835 HIGH motif; other site 198215001836 nucleotide binding site [chemical binding]; other site 198215001837 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 198215001838 KMSKS motif; other site 198215001839 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 198215001840 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 198215001841 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198215001842 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198215001843 active site turn [active] 198215001844 phosphorylation site [posttranslational modification] 198215001845 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198215001846 HPr interaction site; other site 198215001847 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198215001848 active site 198215001849 phosphorylation site [posttranslational modification] 198215001850 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 198215001851 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198215001852 active site 198215001853 trimer interface [polypeptide binding]; other site 198215001854 allosteric site; other site 198215001855 active site lid [active] 198215001856 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198215001857 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 198215001858 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 198215001859 active site 198215001860 dimer interface [polypeptide binding]; other site 198215001861 MarR family; Region: MarR; pfam01047 198215001862 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198215001863 ROK family; Region: ROK; pfam00480 198215001864 asparagine synthetase B; Provisional; Region: asnB; PRK09431 198215001865 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 198215001866 active site 198215001867 dimer interface [polypeptide binding]; other site 198215001868 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 198215001869 Ligand Binding Site [chemical binding]; other site 198215001870 Molecular Tunnel; other site 198215001871 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 198215001872 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 198215001873 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 198215001874 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198215001875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215001876 FeS/SAM binding site; other site 198215001877 TRAM domain; Region: TRAM; pfam01938 198215001878 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 198215001879 PhoH-like protein; Region: PhoH; pfam02562 198215001880 metal-binding heat shock protein; Provisional; Region: PRK00016 198215001881 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 198215001882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198215001883 Transporter associated domain; Region: CorC_HlyC; smart01091 198215001884 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 198215001885 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 198215001886 putative active site [active] 198215001887 catalytic triad [active] 198215001888 putative dimer interface [polypeptide binding]; other site 198215001889 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 198215001890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215001891 substrate binding pocket [chemical binding]; other site 198215001892 membrane-bound complex binding site; other site 198215001893 hinge residues; other site 198215001894 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198215001895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215001896 dimer interface [polypeptide binding]; other site 198215001897 conserved gate region; other site 198215001898 putative PBP binding loops; other site 198215001899 ABC-ATPase subunit interface; other site 198215001900 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198215001901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215001902 dimer interface [polypeptide binding]; other site 198215001903 conserved gate region; other site 198215001904 putative PBP binding loops; other site 198215001905 ABC-ATPase subunit interface; other site 198215001906 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198215001907 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198215001908 Walker A/P-loop; other site 198215001909 ATP binding site [chemical binding]; other site 198215001910 Q-loop/lid; other site 198215001911 ABC transporter signature motif; other site 198215001912 Walker B; other site 198215001913 D-loop; other site 198215001914 H-loop/switch region; other site 198215001915 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198215001916 active site 198215001917 tetramer interface [polypeptide binding]; other site 198215001918 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 198215001919 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 198215001920 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198215001921 Sel1-like repeats; Region: SEL1; smart00671 198215001922 Sel1-like repeats; Region: SEL1; smart00671 198215001923 Sel1-like repeats; Region: SEL1; smart00671 198215001924 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 198215001925 HSP70 interaction site [polypeptide binding]; other site 198215001926 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 198215001927 Sel1-like repeats; Region: SEL1; smart00671 198215001928 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198215001929 Sel1-like repeats; Region: SEL1; smart00671 198215001930 Sel1-like repeats; Region: SEL1; smart00671 198215001931 Sel1-like repeats; Region: SEL1; smart00671 198215001932 Sel1-like repeats; Region: SEL1; smart00671 198215001933 Sel1-like repeats; Region: SEL1; smart00671 198215001934 Sel1-like repeats; Region: SEL1; smart00671 198215001935 hypothetical protein; Provisional; Region: PRK11032 198215001936 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 198215001937 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 198215001938 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 198215001939 HIGH motif; other site 198215001940 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198215001941 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 198215001942 active site 198215001943 KMSKS motif; other site 198215001944 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 198215001945 tRNA binding surface [nucleotide binding]; other site 198215001946 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 198215001947 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 198215001948 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 198215001949 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 198215001950 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 198215001951 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 198215001952 active site 198215001953 (T/H)XGH motif; other site 198215001954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198215001955 catalytic core [active] 198215001956 Oligomerisation domain; Region: Oligomerisation; cl00519 198215001957 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 198215001958 penicillin-binding protein 2; Provisional; Region: PRK10795 198215001959 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 198215001960 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198215001961 cell wall shape-determining protein; Provisional; Region: PRK10794 198215001962 rare lipoprotein A; Provisional; Region: PRK10672 198215001963 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 198215001964 Sporulation related domain; Region: SPOR; pfam05036 198215001965 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 198215001966 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 198215001967 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 198215001968 hypothetical protein; Provisional; Region: PRK04998 198215001969 lipoate-protein ligase B; Provisional; Region: PRK14342 198215001970 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 198215001971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215001972 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 198215001973 substrate binding pocket [chemical binding]; other site 198215001974 dimerization interface [polypeptide binding]; other site 198215001975 lipoyl synthase; Provisional; Region: PRK05481 198215001976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215001977 FeS/SAM binding site; other site 198215001978 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 198215001979 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 198215001980 Predicted amidohydrolase [General function prediction only]; Region: COG0388 198215001981 active site 198215001982 catalytic triad [active] 198215001983 dimer interface [polypeptide binding]; other site 198215001984 chromosome condensation membrane protein; Provisional; Region: PRK14196 198215001985 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198215001986 DNA-binding site [nucleotide binding]; DNA binding site 198215001987 RNA-binding motif; other site 198215001988 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 198215001989 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 198215001990 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 198215001991 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 198215001992 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 198215001993 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 198215001994 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 198215001995 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 198215001996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215001997 Transposase; Region: HTH_Tnp_1; pfam01527 198215001998 HTH-like domain; Region: HTH_21; pfam13276 198215001999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002000 Integrase core domain; Region: rve; pfam00665 198215002001 Integrase core domain; Region: rve_3; pfam13683 198215002002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 198215002003 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 198215002004 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 198215002005 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 198215002006 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 198215002007 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 198215002008 Phage terminase large subunit; Region: Terminase_3; pfam04466 198215002009 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215002010 HTH-like domain; Region: HTH_21; pfam13276 198215002011 Integrase core domain; Region: rve; pfam00665 198215002012 Integrase core domain; Region: rve_3; pfam13683 198215002013 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215002014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002015 Phage terminase large subunit; Region: Terminase_3; cl12054 198215002016 Integrase core domain; Region: rve; pfam00665 198215002017 Integrase core domain; Region: rve_3; pfam13683 198215002018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002019 Transposase; Region: HTH_Tnp_1; pfam01527 198215002020 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 198215002021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002022 Transposase; Region: HTH_Tnp_1; pfam01527 198215002023 putative transposase OrfB; Reviewed; Region: PHA02517 198215002024 Integrase core domain; Region: rve; pfam00665 198215002025 Integrase core domain; Region: rve_3; pfam13683 198215002026 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 198215002027 Lysis protein S; Region: Lysis_S; pfam04971 198215002028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002029 Integrase core domain; Region: rve; pfam00665 198215002030 Integrase core domain; Region: rve_3; pfam13683 198215002031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002032 Transposase; Region: HTH_Tnp_1; pfam01527 198215002033 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 198215002034 active site 198215002035 metal binding site [ion binding]; metal-binding site 198215002036 interdomain interaction site; other site 198215002037 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 198215002038 Integrase core domain; Region: rve; pfam00665 198215002039 Integrase core domain; Region: rve_3; pfam13683 198215002040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002041 Transposase; Region: HTH_Tnp_1; pfam01527 198215002042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215002043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198215002044 Walker A motif; other site 198215002045 ATP binding site [chemical binding]; other site 198215002046 Walker B motif; other site 198215002047 arginine finger; other site 198215002048 replicative DNA helicase; Region: DnaB; TIGR00665 198215002049 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 198215002050 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 198215002051 Walker A motif; other site 198215002052 ATP binding site [chemical binding]; other site 198215002053 Walker B motif; other site 198215002054 DNA binding loops [nucleotide binding] 198215002055 Phage NinH protein; Region: Phage_NinH; pfam06322 198215002056 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 198215002057 Lysis protein S; Region: Lysis_S; pfam04971 198215002058 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 198215002059 catalytic residues [active] 198215002060 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 198215002061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002062 Transposase; Region: HTH_Tnp_1; pfam01527 198215002063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002064 Integrase core domain; Region: rve; pfam00665 198215002065 Integrase core domain; Region: rve_3; pfam13683 198215002066 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 198215002067 gpW; Region: gpW; pfam02831 198215002068 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 198215002069 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 198215002070 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 198215002071 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 198215002072 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 198215002073 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 198215002074 tandem repeat interface [polypeptide binding]; other site 198215002075 oligomer interface [polypeptide binding]; other site 198215002076 active site residues [active] 198215002077 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 198215002078 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 198215002079 DNA packaging protein FI; Region: Packaging_FI; pfam14000 198215002080 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 198215002081 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 198215002082 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 198215002083 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 198215002084 Bacterial Ig-like domain 2; Region: BID_2; smart00635 198215002085 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 198215002086 Minor tail protein T; Region: Phage_tail_T; cl05636 198215002087 Phage-related minor tail protein [Function unknown]; Region: COG5281 198215002088 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 198215002089 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 198215002090 Phage-related protein [Function unknown]; Region: COG4718 198215002091 Phage-related protein [Function unknown]; Region: gp18; COG4672 198215002092 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 198215002093 MPN+ (JAMM) motif; other site 198215002094 Zinc-binding site [ion binding]; other site 198215002095 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198215002096 NlpC/P60 family; Region: NLPC_P60; cl17555 198215002097 Phage-related protein, tail component [Function unknown]; Region: COG4723 198215002098 Phage-related protein, tail component [Function unknown]; Region: COG4733 198215002099 Putative phage tail protein; Region: Phage-tail_3; pfam13550 198215002100 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198215002101 Interdomain contacts; other site 198215002102 Cytokine receptor motif; other site 198215002103 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 198215002104 Fibronectin type III protein; Region: DUF3672; pfam12421 198215002105 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 198215002106 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 198215002107 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198215002108 Transposase, Mutator family; Region: Transposase_mut; pfam00872 198215002109 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 198215002110 substrate binding site [chemical binding]; other site 198215002111 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 198215002112 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198215002113 inhibitor-cofactor binding pocket; inhibition site 198215002114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215002115 catalytic residue [active] 198215002116 biotin synthase; Provisional; Region: PRK15108 198215002117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215002118 FeS/SAM binding site; other site 198215002119 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 198215002120 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 198215002121 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 198215002122 substrate-cofactor binding pocket; other site 198215002123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215002124 catalytic residue [active] 198215002125 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 198215002126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215002127 S-adenosylmethionine binding site [chemical binding]; other site 198215002128 AAA domain; Region: AAA_26; pfam13500 198215002129 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198215002130 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 198215002131 ADP binding site [chemical binding]; other site 198215002132 excinuclease ABC subunit B; Provisional; Region: PRK05298 198215002133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215002134 ATP binding site [chemical binding]; other site 198215002135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215002136 nucleotide binding region [chemical binding]; other site 198215002137 ATP-binding site [chemical binding]; other site 198215002138 Ultra-violet resistance protein B; Region: UvrB; pfam12344 198215002139 UvrB/uvrC motif; Region: UVR; pfam02151 198215002140 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 198215002141 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 198215002142 putative substrate binding pocket [chemical binding]; other site 198215002143 dimer interface [polypeptide binding]; other site 198215002144 phosphate binding site [ion binding]; other site 198215002145 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 198215002146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215002147 FeS/SAM binding site; other site 198215002148 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 198215002149 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 198215002150 MPT binding site; other site 198215002151 trimer interface [polypeptide binding]; other site 198215002152 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 198215002153 trimer interface [polypeptide binding]; other site 198215002154 dimer interface [polypeptide binding]; other site 198215002155 putative active site [active] 198215002156 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 198215002157 MoaE interaction surface [polypeptide binding]; other site 198215002158 MoeB interaction surface [polypeptide binding]; other site 198215002159 thiocarboxylated glycine; other site 198215002160 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 198215002161 MoaE homodimer interface [polypeptide binding]; other site 198215002162 MoaD interaction [polypeptide binding]; other site 198215002163 active site residues [active] 198215002164 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 198215002165 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 198215002166 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 198215002167 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 198215002168 Predicted integral membrane protein [Function unknown]; Region: COG0392 198215002169 cardiolipin synthase 2; Provisional; Region: PRK11263 198215002170 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198215002171 putative active site [active] 198215002172 catalytic site [active] 198215002173 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 198215002174 putative active site [active] 198215002175 catalytic site [active] 198215002176 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 198215002177 putative catalytic site [active] 198215002178 putative metal binding site [ion binding]; other site 198215002179 putative phosphate binding site [ion binding]; other site 198215002180 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 198215002181 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198215002182 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198215002183 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198215002184 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 198215002185 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198215002186 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198215002187 Walker A/P-loop; other site 198215002188 ATP binding site [chemical binding]; other site 198215002189 Q-loop/lid; other site 198215002190 ABC transporter signature motif; other site 198215002191 Walker B; other site 198215002192 D-loop; other site 198215002193 H-loop/switch region; other site 198215002194 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 198215002195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198215002196 Walker A/P-loop; other site 198215002197 ATP binding site [chemical binding]; other site 198215002198 Q-loop/lid; other site 198215002199 ABC transporter signature motif; other site 198215002200 Walker B; other site 198215002201 D-loop; other site 198215002202 H-loop/switch region; other site 198215002203 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 198215002204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215002205 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215002206 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 198215002207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215002208 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 198215002209 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 198215002210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198215002211 ATP binding site [chemical binding]; other site 198215002212 Mg++ binding site [ion binding]; other site 198215002213 motif III; other site 198215002214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215002215 nucleotide binding region [chemical binding]; other site 198215002216 ATP-binding site [chemical binding]; other site 198215002217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 198215002218 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 198215002219 DEAD_2; Region: DEAD_2; pfam06733 198215002220 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198215002221 glycosyl transferase family protein; Provisional; Region: PRK08136 198215002222 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198215002223 putative dehydrogenase; Provisional; Region: PRK10098 198215002224 hypothetical protein; Provisional; Region: PRK10259 198215002225 hypothetical protein; Provisional; Region: PRK11019 198215002226 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 198215002227 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215002228 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215002229 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215002230 hypothetical protein; Provisional; Region: PRK10259 198215002231 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 198215002232 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 198215002233 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 198215002234 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198215002235 Walker A/P-loop; other site 198215002236 ATP binding site [chemical binding]; other site 198215002237 Q-loop/lid; other site 198215002238 ABC transporter signature motif; other site 198215002239 Walker B; other site 198215002240 D-loop; other site 198215002241 H-loop/switch region; other site 198215002242 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198215002243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215002244 dimer interface [polypeptide binding]; other site 198215002245 conserved gate region; other site 198215002246 putative PBP binding loops; other site 198215002247 ABC-ATPase subunit interface; other site 198215002248 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 198215002249 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215002250 substrate binding pocket [chemical binding]; other site 198215002251 membrane-bound complex binding site; other site 198215002252 hinge residues; other site 198215002253 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 198215002254 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 198215002255 dimerization interface [polypeptide binding]; other site 198215002256 DPS ferroxidase diiron center [ion binding]; other site 198215002257 ion pore; other site 198215002258 threonine and homoserine efflux system; Provisional; Region: PRK10532 198215002259 EamA-like transporter family; Region: EamA; pfam00892 198215002260 outer membrane protein X; Provisional; Region: ompX; PRK09408 198215002261 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 198215002262 Sulfatase; Region: Sulfatase; pfam00884 198215002263 manganese transport regulator MntR; Provisional; Region: PRK11050 198215002264 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 198215002265 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 198215002266 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198215002267 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 198215002268 transmembrane helices; other site 198215002269 L,D-transpeptidase; Provisional; Region: PRK10260 198215002270 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198215002271 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 198215002272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215002273 Walker A/P-loop; other site 198215002274 ATP binding site [chemical binding]; other site 198215002275 Q-loop/lid; other site 198215002276 ABC transporter signature motif; other site 198215002277 Walker B; other site 198215002278 D-loop; other site 198215002279 H-loop/switch region; other site 198215002280 ABC transporter; Region: ABC_tran_2; pfam12848 198215002281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198215002282 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 198215002283 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 198215002284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215002285 active site 198215002286 motif I; other site 198215002287 motif II; other site 198215002288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215002289 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 198215002290 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 198215002291 dimer interface [polypeptide binding]; other site 198215002292 active site 198215002293 glycine loop; other site 198215002294 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 198215002295 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 198215002296 active site 198215002297 intersubunit interactions; other site 198215002298 catalytic residue [active] 198215002299 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 198215002300 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198215002301 ATP binding site [chemical binding]; other site 198215002302 substrate interface [chemical binding]; other site 198215002303 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 198215002304 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 198215002305 dimer interface [polypeptide binding]; other site 198215002306 putative functional site; other site 198215002307 putative MPT binding site; other site 198215002308 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 198215002309 catalytic nucleophile [active] 198215002310 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 198215002311 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215002312 Walker A/P-loop; other site 198215002313 ATP binding site [chemical binding]; other site 198215002314 Q-loop/lid; other site 198215002315 ABC transporter signature motif; other site 198215002316 Walker B; other site 198215002317 D-loop; other site 198215002318 H-loop/switch region; other site 198215002319 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198215002320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215002321 Walker A/P-loop; other site 198215002322 ATP binding site [chemical binding]; other site 198215002323 Q-loop/lid; other site 198215002324 ABC transporter signature motif; other site 198215002325 Walker B; other site 198215002326 D-loop; other site 198215002327 H-loop/switch region; other site 198215002328 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198215002329 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 198215002330 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 198215002331 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 198215002332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215002333 dimer interface [polypeptide binding]; other site 198215002334 conserved gate region; other site 198215002335 putative PBP binding loops; other site 198215002336 ABC-ATPase subunit interface; other site 198215002337 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 198215002338 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198215002339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215002340 dimer interface [polypeptide binding]; other site 198215002341 conserved gate region; other site 198215002342 putative PBP binding loops; other site 198215002343 ABC-ATPase subunit interface; other site 198215002344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198215002345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198215002346 metal binding site [ion binding]; metal-binding site 198215002347 active site 198215002348 I-site; other site 198215002349 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 198215002350 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198215002351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215002352 FeS/SAM binding site; other site 198215002353 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 198215002354 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198215002355 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 198215002356 putative C-terminal domain interface [polypeptide binding]; other site 198215002357 putative GSH binding site (G-site) [chemical binding]; other site 198215002358 putative dimer interface [polypeptide binding]; other site 198215002359 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 198215002360 N-terminal domain interface [polypeptide binding]; other site 198215002361 dimer interface [polypeptide binding]; other site 198215002362 substrate binding pocket (H-site) [chemical binding]; other site 198215002363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002364 Transposase; Region: HTH_Tnp_1; pfam01527 198215002365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002366 Integrase core domain; Region: rve; pfam00665 198215002367 Integrase core domain; Region: rve_3; pfam13683 198215002368 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 198215002369 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198215002370 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215002371 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 198215002372 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198215002373 active site 198215002374 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 198215002375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215002376 putative substrate translocation pore; other site 198215002377 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 198215002378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215002379 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198215002380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215002381 putative substrate translocation pore; other site 198215002382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198215002383 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 198215002384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215002385 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 198215002386 putative transporter; Provisional; Region: PRK04972 198215002387 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 198215002388 TrkA-C domain; Region: TrkA_C; pfam02080 198215002389 TrkA-C domain; Region: TrkA_C; pfam02080 198215002390 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 198215002391 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 198215002392 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 198215002393 GSH binding site [chemical binding]; other site 198215002394 catalytic residues [active] 198215002395 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 198215002396 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 198215002397 dimer interface [polypeptide binding]; other site 198215002398 FMN binding site [chemical binding]; other site 198215002399 NADPH bind site [chemical binding]; other site 198215002400 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 198215002401 RimK-like ATP-grasp domain; Region: RimK; pfam08443 198215002402 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 198215002403 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 198215002404 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198215002405 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 198215002406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215002407 Walker A/P-loop; other site 198215002408 ATP binding site [chemical binding]; other site 198215002409 Q-loop/lid; other site 198215002410 ABC transporter signature motif; other site 198215002411 Walker B; other site 198215002412 D-loop; other site 198215002413 H-loop/switch region; other site 198215002414 TOBE domain; Region: TOBE_2; pfam08402 198215002415 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 198215002416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215002417 dimer interface [polypeptide binding]; other site 198215002418 conserved gate region; other site 198215002419 putative PBP binding loops; other site 198215002420 ABC-ATPase subunit interface; other site 198215002421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198215002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215002423 dimer interface [polypeptide binding]; other site 198215002424 conserved gate region; other site 198215002425 putative PBP binding loops; other site 198215002426 ABC-ATPase subunit interface; other site 198215002427 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 198215002428 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 198215002429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215002430 S-adenosylmethionine binding site [chemical binding]; other site 198215002431 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 198215002432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215002433 substrate binding pocket [chemical binding]; other site 198215002434 membrane-bound complex binding site; other site 198215002435 hinge residues; other site 198215002436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215002437 dimer interface [polypeptide binding]; other site 198215002438 conserved gate region; other site 198215002439 putative PBP binding loops; other site 198215002440 ABC-ATPase subunit interface; other site 198215002441 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198215002442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215002443 dimer interface [polypeptide binding]; other site 198215002444 conserved gate region; other site 198215002445 putative PBP binding loops; other site 198215002446 ABC-ATPase subunit interface; other site 198215002447 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 198215002448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215002449 substrate binding pocket [chemical binding]; other site 198215002450 membrane-bound complex binding site; other site 198215002451 hinge residues; other site 198215002452 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 198215002453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215002454 Walker A/P-loop; other site 198215002455 ATP binding site [chemical binding]; other site 198215002456 Q-loop/lid; other site 198215002457 ABC transporter signature motif; other site 198215002458 Walker B; other site 198215002459 D-loop; other site 198215002460 H-loop/switch region; other site 198215002461 putative lipoprotein; Provisional; Region: PRK10533 198215002462 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198215002463 hypothetical protein; Provisional; Region: PRK02877 198215002464 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 198215002465 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198215002466 amidase catalytic site [active] 198215002467 Zn binding residues [ion binding]; other site 198215002468 substrate binding site [chemical binding]; other site 198215002469 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198215002470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198215002471 NAD(P) binding site [chemical binding]; other site 198215002472 active site 198215002473 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 198215002474 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 198215002475 putative NAD(P) binding site [chemical binding]; other site 198215002476 putative active site [active] 198215002477 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 198215002478 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 198215002479 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 198215002480 tetramer interface [polypeptide binding]; other site 198215002481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215002482 catalytic residue [active] 198215002483 pyruvate dehydrogenase; Provisional; Region: PRK09124 198215002484 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 198215002485 PYR/PP interface [polypeptide binding]; other site 198215002486 dimer interface [polypeptide binding]; other site 198215002487 tetramer interface [polypeptide binding]; other site 198215002488 TPP binding site [chemical binding]; other site 198215002489 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198215002490 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 198215002491 TPP-binding site [chemical binding]; other site 198215002492 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 198215002493 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 198215002494 FAD binding pocket [chemical binding]; other site 198215002495 FAD binding motif [chemical binding]; other site 198215002496 phosphate binding motif [ion binding]; other site 198215002497 beta-alpha-beta structure motif; other site 198215002498 NAD binding pocket [chemical binding]; other site 198215002499 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198215002500 catalytic loop [active] 198215002501 iron binding site [ion binding]; other site 198215002502 hybrid cluster protein; Provisional; Region: PRK05290 198215002503 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198215002504 ACS interaction site; other site 198215002505 CODH interaction site; other site 198215002506 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 198215002507 hybrid metal cluster; other site 198215002508 Predicted membrane protein [Function unknown]; Region: COG2431 198215002509 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215002510 HTH-like domain; Region: HTH_21; pfam13276 198215002511 Integrase core domain; Region: rve; pfam00665 198215002512 Integrase core domain; Region: rve_3; pfam13683 198215002513 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215002514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002515 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 198215002516 amphipathic channel; other site 198215002517 Asn-Pro-Ala signature motifs; other site 198215002518 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215002519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215002520 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215002521 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215002522 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 198215002523 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 198215002524 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 198215002525 putative active site [active] 198215002526 putative metal-binding site [ion binding]; other site 198215002527 Protein of unknown function (DUF535); Region: DUF535; pfam04393 198215002528 macrolide transporter subunit MacA; Provisional; Region: PRK11578 198215002529 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215002530 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215002531 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 198215002532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198215002533 Walker A/P-loop; other site 198215002534 ATP binding site [chemical binding]; other site 198215002535 Q-loop/lid; other site 198215002536 ABC transporter signature motif; other site 198215002537 Walker B; other site 198215002538 D-loop; other site 198215002539 H-loop/switch region; other site 198215002540 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198215002541 FtsX-like permease family; Region: FtsX; pfam02687 198215002542 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198215002543 DNA-binding site [nucleotide binding]; DNA binding site 198215002544 RNA-binding motif; other site 198215002545 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 198215002546 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 198215002547 Clp amino terminal domain; Region: Clp_N; pfam02861 198215002548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215002549 Walker A motif; other site 198215002550 ATP binding site [chemical binding]; other site 198215002551 Walker B motif; other site 198215002552 arginine finger; other site 198215002553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215002554 Walker A motif; other site 198215002555 ATP binding site [chemical binding]; other site 198215002556 Walker B motif; other site 198215002557 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 198215002558 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 198215002559 rRNA binding site [nucleotide binding]; other site 198215002560 predicted 30S ribosome binding site; other site 198215002561 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 198215002562 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 198215002563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198215002564 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 198215002565 Walker A/P-loop; other site 198215002566 ATP binding site [chemical binding]; other site 198215002567 Q-loop/lid; other site 198215002568 ABC transporter signature motif; other site 198215002569 Walker B; other site 198215002570 D-loop; other site 198215002571 H-loop/switch region; other site 198215002572 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 198215002573 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198215002574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215002575 Walker A/P-loop; other site 198215002576 ATP binding site [chemical binding]; other site 198215002577 Q-loop/lid; other site 198215002578 ABC transporter signature motif; other site 198215002579 Walker B; other site 198215002580 D-loop; other site 198215002581 H-loop/switch region; other site 198215002582 thioredoxin reductase; Provisional; Region: PRK10262 198215002583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198215002584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215002585 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 198215002586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215002587 putative DNA binding site [nucleotide binding]; other site 198215002588 putative Zn2+ binding site [ion binding]; other site 198215002589 AsnC family; Region: AsnC_trans_reg; pfam01037 198215002590 DNA translocase FtsK; Provisional; Region: PRK10263 198215002591 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 198215002592 DNA translocase FtsK; Provisional; Region: PRK10263 198215002593 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198215002594 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 198215002595 periplasmic chaperone LolA; Region: lolA; TIGR00547 198215002596 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 198215002597 recombination factor protein RarA; Reviewed; Region: PRK13342 198215002598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215002599 Walker A motif; other site 198215002600 ATP binding site [chemical binding]; other site 198215002601 Walker B motif; other site 198215002602 arginine finger; other site 198215002603 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 198215002604 seryl-tRNA synthetase; Provisional; Region: PRK05431 198215002605 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 198215002606 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 198215002607 dimer interface [polypeptide binding]; other site 198215002608 active site 198215002609 motif 1; other site 198215002610 motif 2; other site 198215002611 motif 3; other site 198215002612 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 198215002613 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 198215002614 putative [Fe4-S4] binding site [ion binding]; other site 198215002615 putative molybdopterin cofactor binding site [chemical binding]; other site 198215002616 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 198215002617 putative molybdopterin cofactor binding site; other site 198215002618 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 198215002619 4Fe-4S binding domain; Region: Fer4; pfam00037 198215002620 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 198215002621 Isochorismatase family; Region: Isochorismatase; pfam00857 198215002622 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 198215002623 catalytic triad [active] 198215002624 dimer interface [polypeptide binding]; other site 198215002625 conserved cis-peptide bond; other site 198215002626 putative MFS family transporter protein; Provisional; Region: PRK03633 198215002627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215002628 putative substrate translocation pore; other site 198215002629 Homeodomain-like domain; Region: HTH_23; pfam13384 198215002630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002631 Transposase; Region: HTH_Tnp_1; pfam01527 198215002632 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215002633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215002634 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198215002635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215002636 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 198215002637 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215002638 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215002639 IS911 orfB; IS, phage, Tn; Transposon-related functions; residues 1 to 208 of 208 are 100.00 pct identical to residues 72 to 279 of 279 from GenPept : >gb|AAL72449.1| (AF386526) InsB [Shigella flexneri 2a]; partial 198215002640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002641 Transposase; Region: HTH_Tnp_1; pfam01527 198215002642 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 198215002643 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 198215002644 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 198215002645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002646 Transposase; Region: HTH_Tnp_1; pfam01527 198215002647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002648 Integrase core domain; Region: rve; pfam00665 198215002649 Integrase core domain; Region: rve_3; pfam13683 198215002650 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 198215002651 Hok/gef family; Region: HOK_GEF; pfam01848 198215002652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 198215002653 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 198215002654 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 198215002655 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 198215002656 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 198215002657 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215002658 HTH-like domain; Region: HTH_21; pfam13276 198215002659 Integrase core domain; Region: rve; pfam00665 198215002660 Integrase core domain; Region: rve_3; pfam13683 198215002661 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215002662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002663 Ash protein family; Region: Phage_ASH; pfam10554 198215002664 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 198215002665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002666 Transposase; Region: HTH_Tnp_1; pfam01527 198215002667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002668 Integrase core domain; Region: rve; pfam00665 198215002669 Integrase core domain; Region: rve_3; pfam13683 198215002670 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 198215002671 Integrase core domain; Region: rve; pfam00665 198215002672 Integrase core domain; Region: rve_3; pfam13683 198215002673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002674 Transposase; Region: HTH_Tnp_1; pfam01527 198215002675 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198215002676 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198215002677 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 198215002678 6-phosphogluconolactonase; Provisional; Region: PRK11028 198215002679 PrpF protein; Region: PrpF; pfam04303 198215002680 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198215002681 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 198215002682 transmembrane helices; other site 198215002683 putative hydratase; Provisional; Region: PRK11413 198215002684 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 198215002685 substrate binding site [chemical binding]; other site 198215002686 ligand binding site [chemical binding]; other site 198215002687 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 198215002688 substrate binding site [chemical binding]; other site 198215002689 acyl-CoA thioesterase; Provisional; Region: PRK10531 198215002690 putative pectinesterase; Region: PLN02432; cl01911 198215002691 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 198215002692 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 198215002693 dimer interface [polypeptide binding]; other site 198215002694 active site 198215002695 Int/Topo IB signature motif; other site 198215002696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002697 Integrase core domain; Region: rve; pfam00665 198215002698 Integrase core domain; Region: rve_3; pfam13683 198215002699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002700 Transposase; Region: HTH_Tnp_1; pfam01527 198215002701 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 198215002702 catalytic residue [active] 198215002703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002704 Transposase; Region: HTH_Tnp_1; pfam01527 198215002705 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215002706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215002707 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198215002708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215002709 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 198215002710 Transposase; Region: HTH_Tnp_1; cl17663 198215002711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002712 putative transposase OrfB; Reviewed; Region: PHA02517 198215002713 HTH-like domain; Region: HTH_21; pfam13276 198215002714 Integrase core domain; Region: rve; pfam00665 198215002715 Integrase core domain; Region: rve_3; pfam13683 198215002716 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215002717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215002718 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215002719 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215002720 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215002721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002722 Transposase; Region: HTH_Tnp_1; pfam01527 198215002723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002724 Integrase core domain; Region: rve; pfam00665 198215002725 Integrase core domain; Region: rve_3; pfam13683 198215002726 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215002727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215002728 Integrase core domain; Region: rve; pfam00665 198215002729 Integrase core domain; Region: rve_3; pfam13683 198215002730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002731 Transposase; Region: HTH_Tnp_1; pfam01527 198215002732 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 198215002733 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215002734 FeS/SAM binding site; other site 198215002735 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 198215002736 Pyruvate formate lyase 1; Region: PFL1; cd01678 198215002737 coenzyme A binding site [chemical binding]; other site 198215002738 active site 198215002739 catalytic residues [active] 198215002740 glycine loop; other site 198215002741 formate transporter; Provisional; Region: PRK10805 198215002742 uncharacterized domain; Region: TIGR00702 198215002743 YcaO-like family; Region: YcaO; pfam02624 198215002744 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 198215002745 homodimer interface [polypeptide binding]; other site 198215002746 substrate-cofactor binding pocket; other site 198215002747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215002748 catalytic residue [active] 198215002749 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 198215002750 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 198215002751 hinge; other site 198215002752 active site 198215002753 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215002754 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215002755 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215002756 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 198215002757 cytidylate kinase; Provisional; Region: cmk; PRK00023 198215002758 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 198215002759 CMP-binding site; other site 198215002760 The sites determining sugar specificity; other site 198215002761 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 198215002762 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 198215002763 RNA binding site [nucleotide binding]; other site 198215002764 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 198215002765 RNA binding site [nucleotide binding]; other site 198215002766 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 198215002767 RNA binding site [nucleotide binding]; other site 198215002768 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 198215002769 RNA binding site [nucleotide binding]; other site 198215002770 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 198215002771 RNA binding site [nucleotide binding]; other site 198215002772 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198215002773 IHF dimer interface [polypeptide binding]; other site 198215002774 IHF - DNA interface [nucleotide binding]; other site 198215002775 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 198215002776 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198215002777 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 198215002778 Walker A/P-loop; other site 198215002779 ATP binding site [chemical binding]; other site 198215002780 Q-loop/lid; other site 198215002781 ABC transporter signature motif; other site 198215002782 Walker B; other site 198215002783 D-loop; other site 198215002784 H-loop/switch region; other site 198215002785 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 198215002786 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 198215002787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 198215002788 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 198215002789 hypothetical protein; Provisional; Region: PRK11827 198215002790 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 198215002791 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 198215002792 Ligand binding site; other site 198215002793 oligomer interface; other site 198215002794 hypothetical protein; Provisional; Region: PRK10593 198215002795 Uncharacterized conserved protein [Function unknown]; Region: COG1434 198215002796 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198215002797 putative active site [active] 198215002798 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198215002799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215002800 S-adenosylmethionine binding site [chemical binding]; other site 198215002801 condesin subunit F; Provisional; Region: PRK05260 198215002802 condesin subunit E; Provisional; Region: PRK05256 198215002803 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 198215002804 MukB N-terminal; Region: MukB; pfam04310 198215002805 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 198215002806 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215002807 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215002808 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215002809 murein L,D-transpeptidase; Provisional; Region: PRK10594 198215002810 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198215002811 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198215002812 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198215002813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 198215002814 Peptidase M15; Region: Peptidase_M15_3; cl01194 198215002815 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198215002816 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 198215002817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215002819 homodimer interface [polypeptide binding]; other site 198215002820 catalytic residue [active] 198215002821 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198215002822 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198215002823 trimer interface [polypeptide binding]; other site 198215002824 eyelet of channel; other site 198215002825 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 198215002826 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 198215002827 putative dimer interface [polypeptide binding]; other site 198215002828 putative anticodon binding site; other site 198215002829 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 198215002830 homodimer interface [polypeptide binding]; other site 198215002831 motif 1; other site 198215002832 motif 2; other site 198215002833 active site 198215002834 motif 3; other site 198215002835 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 198215002836 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 198215002837 active site 198215002838 aminopeptidase N; Provisional; Region: pepN; PRK14015 198215002839 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 198215002840 active site 198215002841 Zn binding site [ion binding]; other site 198215002842 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 198215002843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215002844 Walker A/P-loop; other site 198215002845 ATP binding site [chemical binding]; other site 198215002846 Q-loop/lid; other site 198215002847 ABC transporter signature motif; other site 198215002848 Walker B; other site 198215002849 D-loop; other site 198215002850 H-loop/switch region; other site 198215002851 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215002852 HTH-like domain; Region: HTH_21; pfam13276 198215002853 Integrase core domain; Region: rve; pfam00665 198215002854 Integrase core domain; Region: rve_3; pfam13683 198215002855 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215002856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002857 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 198215002858 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 198215002859 active site 198215002860 dimer interface [polypeptide binding]; other site 198215002861 non-prolyl cis peptide bond; other site 198215002862 insertion regions; other site 198215002863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215002864 substrate binding pocket [chemical binding]; other site 198215002865 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198215002866 membrane-bound complex binding site; other site 198215002867 hinge residues; other site 198215002868 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 198215002869 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198215002870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215002871 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215002872 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215002873 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215002874 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215002875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215002876 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215002877 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215002878 outer membrane usher protein; Provisional; Region: PRK15193 198215002879 PapC N-terminal domain; Region: PapC_N; pfam13954 198215002880 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 198215002881 PapC C-terminal domain; Region: PapC_C; pfam13953 198215002882 Fimbrial protein; Region: Fimbrial; cl01416 198215002883 Fimbrial protein; Region: Fimbrial; cl01416 198215002884 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198215002885 putativi pili assembly chaperone; Provisional; Region: PRK11385 198215002886 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 198215002887 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 198215002888 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 198215002889 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 198215002890 quinone interaction residues [chemical binding]; other site 198215002891 active site 198215002892 catalytic residues [active] 198215002893 FMN binding site [chemical binding]; other site 198215002894 substrate binding site [chemical binding]; other site 198215002895 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 198215002896 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 198215002897 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 198215002898 MOSC domain; Region: MOSC; pfam03473 198215002899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198215002900 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 198215002901 catalytic loop [active] 198215002902 iron binding site [ion binding]; other site 198215002903 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 198215002904 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 198215002905 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 198215002906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215002907 S-adenosylmethionine binding site [chemical binding]; other site 198215002908 ABC transporter ATPase component; Reviewed; Region: PRK11147 198215002909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215002910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215002911 Walker A/P-loop; other site 198215002912 Walker A/P-loop; other site 198215002913 ATP binding site [chemical binding]; other site 198215002914 ATP binding site [chemical binding]; other site 198215002915 Q-loop/lid; other site 198215002916 Q-loop/lid; other site 198215002917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198215002918 ABC transporter signature motif; other site 198215002919 Walker B; other site 198215002920 D-loop; other site 198215002921 ABC transporter; Region: ABC_tran_2; pfam12848 198215002922 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198215002923 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 198215002924 Paraquat-inducible protein A; Region: PqiA; pfam04403 198215002925 Paraquat-inducible protein A; Region: PqiA; pfam04403 198215002926 paraquat-inducible protein B; Provisional; Region: PRK10807 198215002927 mce related protein; Region: MCE; pfam02470 198215002928 mce related protein; Region: MCE; pfam02470 198215002929 mce related protein; Region: MCE; pfam02470 198215002930 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 198215002931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 198215002932 Protein of unknown function (DUF330); Region: DUF330; pfam03886 198215002933 Ribosome modulation factor; Region: RMF; pfam04957 198215002934 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 198215002935 active site 1 [active] 198215002936 dimer interface [polypeptide binding]; other site 198215002937 active site 2 [active] 198215002938 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 198215002939 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198215002940 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 198215002941 outer membrane protein A; Reviewed; Region: PRK10808 198215002942 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 198215002943 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198215002944 ligand binding site [chemical binding]; other site 198215002945 cell division inhibitor SulA; Region: sula; TIGR00623 198215002946 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 198215002947 TfoX C-terminal domain; Region: TfoX_C; pfam04994 198215002948 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215002949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215002950 HTH-like domain; Region: HTH_21; pfam13276 198215002951 Integrase core domain; Region: rve; pfam00665 198215002952 TIGR01666 family membrane protein; Region: YCCS 198215002953 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 198215002954 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198215002955 Predicted membrane protein [Function unknown]; Region: COG3304 198215002956 Domain of unknown function (DUF307); Region: DUF307; pfam03733 198215002957 Domain of unknown function (DUF307); Region: DUF307; pfam03733 198215002958 DNA helicase IV; Provisional; Region: helD; PRK11054 198215002959 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 198215002960 Part of AAA domain; Region: AAA_19; pfam13245 198215002961 Family description; Region: UvrD_C_2; pfam13538 198215002962 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 198215002963 active site 198215002964 dimer interfaces [polypeptide binding]; other site 198215002965 catalytic residues [active] 198215002966 hypothetical protein; Provisional; Region: PRK03641 198215002967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 198215002968 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 198215002969 heat shock protein HspQ; Provisional; Region: PRK14129 198215002970 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 198215002971 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 198215002972 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 198215002973 putative RNA binding site [nucleotide binding]; other site 198215002974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215002975 S-adenosylmethionine binding site [chemical binding]; other site 198215002976 Acylphosphatase; Region: Acylphosphatase; cl00551 198215002977 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 198215002978 sulfur transfer protein TusE; Provisional; Region: PRK11508 198215002979 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 198215002980 YccA-like proteins; Region: YccA_like; cd10433 198215002981 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 198215002982 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 198215002983 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 198215002984 hydrogenase 1 large subunit; Provisional; Region: PRK10170 198215002985 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 198215002986 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 198215002987 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 198215002988 putative substrate-binding site; other site 198215002989 nickel binding site [ion binding]; other site 198215002990 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 198215002991 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 198215002992 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 198215002993 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 198215002994 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 198215002995 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 198215002996 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 198215002997 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198215002998 catalytic core [active] 198215002999 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198215003000 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198215003001 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 198215003002 active site 198215003003 polysaccharide export protein Wza; Provisional; Region: PRK15078 198215003004 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 198215003005 SLBB domain; Region: SLBB; pfam10531 198215003006 SLBB domain; Region: SLBB; pfam10531 198215003007 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 198215003008 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 198215003009 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 198215003010 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198215003011 DNA-binding site [nucleotide binding]; DNA binding site 198215003012 RNA-binding motif; other site 198215003013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215003014 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215003015 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215003016 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215003017 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198215003018 DNA-binding site [nucleotide binding]; DNA binding site 198215003019 RNA-binding motif; other site 198215003020 cold shock gene; Provisional; Region: PRK09891 198215003021 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 198215003022 4Fe-4S binding domain; Region: Fer4_5; pfam12801 198215003023 4Fe-4S binding domain; Region: Fer4_5; pfam12801 198215003024 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198215003025 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 198215003026 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 198215003027 putative ligand binding site [chemical binding]; other site 198215003028 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 198215003029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215003030 active site 198215003031 phosphorylation site [posttranslational modification] 198215003032 intermolecular recognition site; other site 198215003033 dimerization interface [polypeptide binding]; other site 198215003034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215003035 DNA binding site [nucleotide binding] 198215003036 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 198215003037 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 198215003038 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215003039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215003040 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215003041 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215003042 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 198215003043 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 198215003044 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 198215003045 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198215003046 HSP70 interaction site [polypeptide binding]; other site 198215003047 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 198215003048 substrate binding site [polypeptide binding]; other site 198215003049 dimer interface [polypeptide binding]; other site 198215003050 hypothetical protein; Provisional; Region: PRK09784 198215003051 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 198215003052 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198215003053 catalytic core [active] 198215003054 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198215003055 hypothetical protein; Provisional; Region: PRK10174 198215003056 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 198215003057 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198215003058 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 198215003059 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 198215003060 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 198215003061 putative FMN binding site [chemical binding]; other site 198215003062 pyrimidine utilization protein D; Region: RutD; TIGR03611 198215003063 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198215003064 homotrimer interaction site [polypeptide binding]; other site 198215003065 putative active site [active] 198215003066 Isochorismatase family; Region: Isochorismatase; pfam00857 198215003067 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 198215003068 catalytic triad [active] 198215003069 conserved cis-peptide bond; other site 198215003070 pyrimidine utilization protein A; Region: RutA; TIGR03612 198215003071 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 198215003072 active site 198215003073 dimer interface [polypeptide binding]; other site 198215003074 non-prolyl cis peptide bond; other site 198215003075 insertion regions; other site 198215003076 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 198215003077 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 198215003078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215003079 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 198215003080 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215003081 Putative transposase; Region: Y2_Tnp; pfam04986 198215003082 Iron permease FTR1 family; Region: FTR1; cl00475 198215003083 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 198215003084 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 198215003085 Imelysin; Region: Peptidase_M75; pfam09375 198215003086 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 198215003087 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 198215003088 putative transposase OrfB; Reviewed; Region: PHA02517 198215003089 HTH-like domain; Region: HTH_21; pfam13276 198215003090 Integrase core domain; Region: rve; pfam00665 198215003091 Integrase core domain; Region: rve_2; pfam13333 198215003092 Transposase; Region: HTH_Tnp_1; cl17663 198215003093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003094 putative hydrolase; Validated; Region: PRK09248 198215003095 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 198215003096 active site 198215003097 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 198215003098 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 198215003099 curli assembly protein CsgF; Provisional; Region: PRK10050 198215003100 curli assembly protein CsgE; Provisional; Region: PRK10386 198215003101 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 198215003102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215003103 DNA binding residues [nucleotide binding] 198215003104 dimerization interface [polypeptide binding]; other site 198215003105 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 198215003106 Curlin associated repeat; Region: Curlin_rpt; pfam07012 198215003107 Curlin associated repeat; Region: Curlin_rpt; pfam07012 198215003108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003109 Transposase; Region: HTH_Tnp_1; pfam01527 198215003110 Integrase core domain; Region: rve; pfam00665 198215003111 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 198215003112 Fimbrial protein; Region: Fimbrial; cl01416 198215003113 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 198215003114 putative ADP-ribose binding site [chemical binding]; other site 198215003115 putative active site [active] 198215003116 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 198215003117 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 198215003118 putative active site [active] 198215003119 catalytic site [active] 198215003120 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 198215003121 putative active site [active] 198215003122 catalytic site [active] 198215003123 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 198215003124 Acyltransferase family; Region: Acyl_transf_3; pfam01757 198215003125 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 198215003126 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 198215003127 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 198215003128 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 198215003129 Ligand binding site; other site 198215003130 DXD motif; other site 198215003131 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215003132 Putative transposase; Region: Y2_Tnp; pfam04986 198215003133 tape measure domain; Region: tape_meas_nterm; TIGR02675 198215003134 Integrase core domain; Region: rve; pfam00665 198215003135 Integrase core domain; Region: rve_3; pfam13683 198215003136 Transposase; Region: HTH_Tnp_1; cl17663 198215003137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003139 Transposase; Region: HTH_Tnp_1; pfam01527 198215003140 Integrase core domain; Region: rve; pfam00665 198215003141 Integrase core domain; Region: rve_3; pfam13683 198215003142 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215003143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003144 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215003145 HTH-like domain; Region: HTH_21; pfam13276 198215003146 Integrase core domain; Region: rve; pfam00665 198215003147 Integrase core domain; Region: rve_3; pfam13683 198215003148 Transposase; Region: HTH_Tnp_1; cl17663 198215003149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003150 Integrase core domain; Region: rve; pfam00665 198215003151 Integrase core domain; Region: rve_3; pfam13683 198215003152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003153 Transposase; Region: HTH_Tnp_1; pfam01527 198215003154 Integrase core domain; Region: rve; pfam00665 198215003155 Integrase core domain; Region: rve_3; pfam13683 198215003156 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 198215003157 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 198215003158 catalytic residues [active] 198215003159 catalytic nucleophile [active] 198215003160 Recombinase; Region: Recombinase; pfam07508 198215003161 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 198215003162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198215003163 putative acyl-acceptor binding pocket; other site 198215003164 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 198215003165 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 198215003166 active site residue [active] 198215003167 hypothetical protein; Provisional; Region: PRK03757 198215003168 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 198215003169 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 198215003170 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 198215003171 hydroxyglutarate oxidase; Provisional; Region: PRK11728 198215003172 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 198215003173 DNA damage-inducible protein I; Provisional; Region: PRK10597 198215003174 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 198215003175 active site 198215003176 substrate binding pocket [chemical binding]; other site 198215003177 dimer interface [polypeptide binding]; other site 198215003178 lipoprotein; Provisional; Region: PRK10598 198215003179 glutaredoxin 2; Provisional; Region: PRK10387 198215003180 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 198215003181 C-terminal domain interface [polypeptide binding]; other site 198215003182 GSH binding site (G-site) [chemical binding]; other site 198215003183 catalytic residues [active] 198215003184 putative dimer interface [polypeptide binding]; other site 198215003185 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 198215003186 N-terminal domain interface [polypeptide binding]; other site 198215003187 multidrug resistance protein MdtH; Provisional; Region: PRK11646 198215003188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215003189 putative substrate translocation pore; other site 198215003190 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 198215003191 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198215003192 hypothetical protein; Provisional; Region: PRK11239 198215003193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 198215003194 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198215003195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198215003196 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198215003197 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 198215003198 MviN-like protein; Region: MVIN; pfam03023 198215003199 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 198215003200 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 198215003201 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 198215003202 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 198215003203 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 198215003204 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 198215003205 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 198215003206 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 198215003207 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 198215003208 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 198215003209 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 198215003210 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198215003211 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 198215003212 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198215003213 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 198215003214 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198215003215 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198215003216 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 198215003217 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 198215003218 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 198215003219 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 198215003220 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 198215003221 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 198215003222 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 198215003223 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 198215003224 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 198215003225 homodimer interface [polypeptide binding]; other site 198215003226 oligonucleotide binding site [chemical binding]; other site 198215003227 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 198215003228 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 198215003229 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 198215003230 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215003231 RNA binding surface [nucleotide binding]; other site 198215003232 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198215003233 active site 198215003234 Maf-like protein; Region: Maf; pfam02545 198215003235 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 198215003236 active site 198215003237 dimer interface [polypeptide binding]; other site 198215003238 hypothetical protein; Provisional; Region: PRK11193 198215003239 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 198215003240 putative phosphate acyltransferase; Provisional; Region: PRK05331 198215003241 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 198215003242 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 198215003243 dimer interface [polypeptide binding]; other site 198215003244 active site 198215003245 CoA binding pocket [chemical binding]; other site 198215003246 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 198215003247 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 198215003248 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 198215003249 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 198215003250 NAD(P) binding site [chemical binding]; other site 198215003251 homotetramer interface [polypeptide binding]; other site 198215003252 homodimer interface [polypeptide binding]; other site 198215003253 active site 198215003254 acyl carrier protein; Provisional; Region: acpP; PRK00982 198215003255 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 198215003256 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198215003257 dimer interface [polypeptide binding]; other site 198215003258 active site 198215003259 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 198215003260 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 198215003261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215003262 catalytic residue [active] 198215003263 conserved hypothetical protein, YceG family; Region: TIGR00247 198215003264 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 198215003265 dimerization interface [polypeptide binding]; other site 198215003266 thymidylate kinase; Validated; Region: tmk; PRK00698 198215003267 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198215003268 TMP-binding site; other site 198215003269 ATP-binding site [chemical binding]; other site 198215003270 DNA polymerase III subunit delta'; Validated; Region: PRK07993 198215003271 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 198215003272 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198215003273 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 198215003274 active site 198215003275 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 198215003276 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198215003277 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198215003278 active site turn [active] 198215003279 phosphorylation site [posttranslational modification] 198215003280 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 198215003281 nucleotide binding site/active site [active] 198215003282 HIT family signature motif; other site 198215003283 catalytic residue [active] 198215003284 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 198215003285 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 198215003286 putative dimer interface [polypeptide binding]; other site 198215003287 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 198215003288 thiamine kinase; Region: ycfN_thiK; TIGR02721 198215003289 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 198215003290 active site 198215003291 substrate binding site [chemical binding]; other site 198215003292 ATP binding site [chemical binding]; other site 198215003293 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 198215003294 beta-hexosaminidase; Provisional; Region: PRK05337 198215003295 hypothetical protein; Provisional; Region: PRK04940 198215003296 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 198215003297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215003298 hypothetical protein; Provisional; Region: PRK11280 198215003299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198215003300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215003301 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198215003302 L,D-transpeptidase; Provisional; Region: PRK10260 198215003303 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215003304 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198215003305 transcription-repair coupling factor; Provisional; Region: PRK10689 198215003306 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 198215003307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215003308 ATP binding site [chemical binding]; other site 198215003309 putative Mg++ binding site [ion binding]; other site 198215003310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215003311 nucleotide binding region [chemical binding]; other site 198215003312 ATP-binding site [chemical binding]; other site 198215003313 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 198215003314 Predicted membrane protein [Function unknown]; Region: COG4763 198215003315 Acyltransferase family; Region: Acyl_transf_3; pfam01757 198215003316 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 198215003317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198215003318 FtsX-like permease family; Region: FtsX; pfam02687 198215003319 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 198215003320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198215003321 Walker A/P-loop; other site 198215003322 ATP binding site [chemical binding]; other site 198215003323 Q-loop/lid; other site 198215003324 ABC transporter signature motif; other site 198215003325 Walker B; other site 198215003326 D-loop; other site 198215003327 H-loop/switch region; other site 198215003328 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 198215003329 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198215003330 FtsX-like permease family; Region: FtsX; pfam02687 198215003331 fructokinase; Reviewed; Region: PRK09557 198215003332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198215003333 nucleotide binding site [chemical binding]; other site 198215003334 NAD-dependent deacetylase; Provisional; Region: PRK00481 198215003335 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 198215003336 NAD+ binding site [chemical binding]; other site 198215003337 substrate binding site [chemical binding]; other site 198215003338 Zn binding site [ion binding]; other site 198215003339 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 198215003340 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 198215003341 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198215003342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003343 dimer interface [polypeptide binding]; other site 198215003344 conserved gate region; other site 198215003345 putative PBP binding loops; other site 198215003346 ABC-ATPase subunit interface; other site 198215003347 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198215003348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003349 dimer interface [polypeptide binding]; other site 198215003350 conserved gate region; other site 198215003351 putative PBP binding loops; other site 198215003352 ABC-ATPase subunit interface; other site 198215003353 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 198215003354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215003355 Walker A/P-loop; other site 198215003356 ATP binding site [chemical binding]; other site 198215003357 Q-loop/lid; other site 198215003358 ABC transporter signature motif; other site 198215003359 Walker B; other site 198215003360 D-loop; other site 198215003361 H-loop/switch region; other site 198215003362 TOBE domain; Region: TOBE_2; pfam08402 198215003363 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 198215003364 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 198215003365 metal binding site [ion binding]; metal-binding site 198215003366 dimer interface [polypeptide binding]; other site 198215003367 Uncharacterized conserved protein [Function unknown]; Region: COG2850 198215003368 Cupin-like domain; Region: Cupin_8; pfam13621 198215003369 integrase; Provisional; Region: PRK09692 198215003370 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198215003371 active site 198215003372 Int/Topo IB signature motif; other site 198215003373 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 198215003374 D5 N terminal like; Region: D5_N; smart00885 198215003375 Phage associated DNA primase [General function prediction only]; Region: COG3378 198215003376 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 198215003377 PerC transcriptional activator; Region: PerC; pfam06069 198215003378 Phage head maturation protease [General function prediction only]; Region: COG3740 198215003379 Phage-related protein [Function unknown]; Region: COG4695 198215003380 Phage portal protein; Region: Phage_portal; pfam04860 198215003381 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 198215003382 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 198215003383 oligomerization interface [polypeptide binding]; other site 198215003384 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 198215003385 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198215003386 active site 198215003387 Phage terminase, small subunit; Region: Terminase_4; cl01525 198215003388 Phage Terminase; Region: Terminase_1; pfam03354 198215003389 sensor protein PhoQ; Provisional; Region: PRK10815 198215003390 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 198215003391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 198215003392 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 198215003393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215003394 ATP binding site [chemical binding]; other site 198215003395 Mg2+ binding site [ion binding]; other site 198215003396 G-X-G motif; other site 198215003397 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 198215003398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215003399 active site 198215003400 phosphorylation site [posttranslational modification] 198215003401 intermolecular recognition site; other site 198215003402 dimerization interface [polypeptide binding]; other site 198215003403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215003404 DNA binding site [nucleotide binding] 198215003405 adenylosuccinate lyase; Provisional; Region: PRK09285 198215003406 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 198215003407 tetramer interface [polypeptide binding]; other site 198215003408 active site 198215003409 putative lysogenization regulator; Reviewed; Region: PRK00218 198215003410 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 198215003411 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 198215003412 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 198215003413 nudix motif; other site 198215003414 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 198215003415 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 198215003416 probable active site [active] 198215003417 isocitrate dehydrogenase; Validated; Region: PRK07362 198215003418 isocitrate dehydrogenase; Reviewed; Region: PRK07006 198215003419 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215003420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215003421 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215003422 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215003423 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198215003424 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198215003425 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 198215003426 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198215003427 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198215003428 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198215003429 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 198215003430 cell division inhibitor MinD; Provisional; Region: PRK10818 198215003431 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 198215003432 Switch I; other site 198215003433 Switch II; other site 198215003434 septum formation inhibitor; Reviewed; Region: minC; PRK03511 198215003435 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 198215003436 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 198215003437 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215003438 HTH-like domain; Region: HTH_21; pfam13276 198215003439 Integrase core domain; Region: rve; pfam00665 198215003440 Integrase core domain; Region: rve_3; pfam13683 198215003441 Transposase; Region: HTH_Tnp_1; cl17663 198215003442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003443 putative transposase OrfB; Reviewed; Region: PHA02517 198215003444 HTH-like domain; Region: HTH_21; pfam13276 198215003445 Integrase core domain; Region: rve; pfam00665 198215003446 Integrase core domain; Region: rve_2; pfam13333 198215003447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 198215003448 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 198215003449 hypothetical protein; Provisional; Region: PRK10691 198215003450 hypothetical protein; Provisional; Region: PRK05170 198215003451 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 198215003452 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 198215003453 Catalytic site [active] 198215003454 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 198215003455 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 198215003456 active site 198215003457 DNA binding site [nucleotide binding] 198215003458 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 198215003459 disulfide bond formation protein B; Provisional; Region: PRK01749 198215003460 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 198215003461 transmembrane helices; other site 198215003462 fatty acid metabolism regulator; Provisional; Region: PRK04984 198215003463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215003464 DNA-binding site [nucleotide binding]; DNA binding site 198215003465 FadR C-terminal domain; Region: FadR_C; pfam07840 198215003466 SpoVR family protein; Provisional; Region: PRK11767 198215003467 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 198215003468 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 198215003469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215003470 alanine racemase; Reviewed; Region: dadX; PRK03646 198215003471 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 198215003472 active site 198215003473 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198215003474 substrate binding site [chemical binding]; other site 198215003475 catalytic residues [active] 198215003476 dimer interface [polypeptide binding]; other site 198215003477 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 198215003478 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 198215003479 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 198215003480 TrkA-C domain; Region: TrkA_C; pfam02080 198215003481 Transporter associated domain; Region: CorC_HlyC; smart01091 198215003482 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 198215003483 dimer interface [polypeptide binding]; other site 198215003484 catalytic triad [active] 198215003485 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 198215003486 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198215003487 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198215003488 catalytic residue [active] 198215003489 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 198215003490 Flagellar regulator YcgR; Region: YcgR; pfam07317 198215003491 PilZ domain; Region: PilZ; pfam07238 198215003492 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 198215003493 molybdenum transport protein ModD; Provisional; Region: PRK06096 198215003494 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 198215003495 dimerization interface [polypeptide binding]; other site 198215003496 active site 198215003497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215003498 S-adenosylmethionine binding site [chemical binding]; other site 198215003499 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198215003500 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198215003501 Walker A/P-loop; other site 198215003502 ATP binding site [chemical binding]; other site 198215003503 Q-loop/lid; other site 198215003504 ABC transporter signature motif; other site 198215003505 Walker B; other site 198215003506 D-loop; other site 198215003507 H-loop/switch region; other site 198215003508 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198215003509 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215003510 ABC-ATPase subunit interface; other site 198215003511 dimer interface [polypeptide binding]; other site 198215003512 putative PBP binding regions; other site 198215003513 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198215003514 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 198215003515 putative metal binding site [ion binding]; other site 198215003516 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215003517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215003518 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215003519 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215003520 trehalase; Provisional; Region: treA; PRK13271 198215003521 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 198215003522 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 198215003523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 198215003524 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198215003525 dimerization domain swap beta strand [polypeptide binding]; other site 198215003526 regulatory protein interface [polypeptide binding]; other site 198215003527 active site 198215003528 regulatory phosphorylation site [posttranslational modification]; other site 198215003529 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 198215003530 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198215003531 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 198215003532 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 198215003533 Dak1 domain; Region: Dak1; pfam02733 198215003534 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 198215003535 PAS domain; Region: PAS; smart00091 198215003536 putative active site [active] 198215003537 heme pocket [chemical binding]; other site 198215003538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215003539 Walker A motif; other site 198215003540 ATP binding site [chemical binding]; other site 198215003541 Walker B motif; other site 198215003542 arginine finger; other site 198215003543 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198215003544 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198215003545 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198215003546 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198215003547 GTP-binding protein YchF; Reviewed; Region: PRK09601 198215003548 YchF GTPase; Region: YchF; cd01900 198215003549 G1 box; other site 198215003550 GTP/Mg2+ binding site [chemical binding]; other site 198215003551 Switch I region; other site 198215003552 G2 box; other site 198215003553 Switch II region; other site 198215003554 G3 box; other site 198215003555 G4 box; other site 198215003556 G5 box; other site 198215003557 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 198215003558 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 198215003559 putative active site [active] 198215003560 catalytic residue [active] 198215003561 hypothetical protein; Provisional; Region: PRK10692 198215003562 putative transporter; Provisional; Region: PRK11660 198215003563 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 198215003564 Sulfate transporter family; Region: Sulfate_transp; pfam00916 198215003565 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 198215003566 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 198215003567 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 198215003568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215003569 active site 198215003570 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 198215003571 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198215003572 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 198215003573 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 198215003574 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 198215003575 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 198215003576 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 198215003577 tRNA; other site 198215003578 putative tRNA binding site [nucleotide binding]; other site 198215003579 putative NADP binding site [chemical binding]; other site 198215003580 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 198215003581 peptide chain release factor 1; Validated; Region: prfA; PRK00591 198215003582 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198215003583 RF-1 domain; Region: RF-1; pfam00472 198215003584 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 198215003585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215003586 hypothetical protein; Provisional; Region: PRK10278 198215003587 hypothetical protein; Provisional; Region: PRK10941 198215003588 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 198215003589 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 198215003590 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198215003591 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 198215003592 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198215003593 cation transport regulator; Reviewed; Region: chaB; PRK09582 198215003594 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 198215003595 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 198215003596 putative active site pocket [active] 198215003597 dimerization interface [polypeptide binding]; other site 198215003598 putative catalytic residue [active] 198215003599 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 198215003600 putative invasin; Provisional; Region: PRK10177 198215003601 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 198215003602 transcriptional regulator NarL; Provisional; Region: PRK10651 198215003603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215003604 active site 198215003605 phosphorylation site [posttranslational modification] 198215003606 intermolecular recognition site; other site 198215003607 dimerization interface [polypeptide binding]; other site 198215003608 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215003609 DNA binding residues [nucleotide binding] 198215003610 dimerization interface [polypeptide binding]; other site 198215003611 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 198215003612 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 198215003613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215003614 dimerization interface [polypeptide binding]; other site 198215003615 Histidine kinase; Region: HisKA_3; pfam07730 198215003616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215003617 ATP binding site [chemical binding]; other site 198215003618 Mg2+ binding site [ion binding]; other site 198215003619 G-X-G motif; other site 198215003620 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 198215003621 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 198215003622 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 198215003623 [4Fe-4S] binding site [ion binding]; other site 198215003624 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198215003625 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198215003626 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198215003627 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 198215003628 molybdopterin cofactor binding site; other site 198215003629 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 198215003630 4Fe-4S binding domain; Region: Fer4; cl02805 198215003631 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 198215003632 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 198215003633 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 198215003634 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 198215003635 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 198215003636 putative active site [active] 198215003637 putative substrate binding site [chemical binding]; other site 198215003638 putative cosubstrate binding site; other site 198215003639 catalytic site [active] 198215003640 SEC-C motif; Region: SEC-C; pfam02810 198215003641 hypothetical protein; Provisional; Region: PRK04233 198215003642 hypothetical protein; Provisional; Region: PRK10279 198215003643 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 198215003644 active site 198215003645 nucleophile elbow; other site 198215003646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215003647 active site 198215003648 response regulator of RpoS; Provisional; Region: PRK10693 198215003649 phosphorylation site [posttranslational modification] 198215003650 intermolecular recognition site; other site 198215003651 dimerization interface [polypeptide binding]; other site 198215003652 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 198215003653 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 198215003654 active site 198215003655 tetramer interface; other site 198215003656 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 198215003657 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 198215003658 thymidine kinase; Provisional; Region: PRK04296 198215003659 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215003660 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215003661 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215003662 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 198215003663 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 198215003664 putative catalytic cysteine [active] 198215003665 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 198215003666 putative active site [active] 198215003667 metal binding site [ion binding]; metal-binding site 198215003668 hypothetical protein; Provisional; Region: PRK11111 198215003669 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215003670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215003671 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215003672 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215003673 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 198215003674 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198215003675 peptide binding site [polypeptide binding]; other site 198215003676 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 198215003677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003678 dimer interface [polypeptide binding]; other site 198215003679 conserved gate region; other site 198215003680 putative PBP binding loops; other site 198215003681 ABC-ATPase subunit interface; other site 198215003682 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 198215003683 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198215003684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003685 dimer interface [polypeptide binding]; other site 198215003686 conserved gate region; other site 198215003687 putative PBP binding loops; other site 198215003688 ABC-ATPase subunit interface; other site 198215003689 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 198215003690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215003691 Walker A/P-loop; other site 198215003692 ATP binding site [chemical binding]; other site 198215003693 Q-loop/lid; other site 198215003694 ABC transporter signature motif; other site 198215003695 Walker B; other site 198215003696 D-loop; other site 198215003697 H-loop/switch region; other site 198215003698 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198215003699 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 198215003700 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215003701 Walker A/P-loop; other site 198215003702 ATP binding site [chemical binding]; other site 198215003703 Q-loop/lid; other site 198215003704 ABC transporter signature motif; other site 198215003705 Walker B; other site 198215003706 D-loop; other site 198215003707 H-loop/switch region; other site 198215003708 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198215003709 dsDNA-mimic protein; Reviewed; Region: PRK05094 198215003710 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 198215003711 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 198215003712 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 198215003713 putative active site [active] 198215003714 catalytic site [active] 198215003715 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 198215003716 putative active site [active] 198215003717 catalytic site [active] 198215003718 voltage-gated potassium channel; Provisional; Region: PRK10537 198215003719 Ion channel; Region: Ion_trans_2; pfam07885 198215003720 TrkA-N domain; Region: TrkA_N; pfam02254 198215003721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215003722 Transposase; Region: HTH_Tnp_1; pfam01527 198215003723 Integrase core domain; Region: rve; pfam00665 198215003724 Integrase core domain; Region: rve_3; pfam13683 198215003725 YciI-like protein; Reviewed; Region: PRK11370 198215003726 transport protein TonB; Provisional; Region: PRK10819 198215003727 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 198215003728 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 198215003729 intracellular septation protein A; Reviewed; Region: PRK00259 198215003730 hypothetical protein; Provisional; Region: PRK02868 198215003731 outer membrane protein W; Provisional; Region: PRK10959 198215003732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 198215003733 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 198215003734 dimerization interface [polypeptide binding]; other site 198215003735 metal binding site [ion binding]; metal-binding site 198215003736 General stress protein [General function prediction only]; Region: GsiB; COG3729 198215003737 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 198215003738 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 198215003739 substrate binding site [chemical binding]; other site 198215003740 active site 198215003741 catalytic residues [active] 198215003742 heterodimer interface [polypeptide binding]; other site 198215003743 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 198215003744 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 198215003745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215003746 catalytic residue [active] 198215003747 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 198215003748 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 198215003749 active site 198215003750 ribulose/triose binding site [chemical binding]; other site 198215003751 phosphate binding site [ion binding]; other site 198215003752 substrate (anthranilate) binding pocket [chemical binding]; other site 198215003753 product (indole) binding pocket [chemical binding]; other site 198215003754 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 198215003755 active site 198215003756 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 198215003757 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198215003758 glutamine binding [chemical binding]; other site 198215003759 catalytic triad [active] 198215003760 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198215003761 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198215003762 anthranilate synthase component I; Provisional; Region: PRK13564 198215003763 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198215003764 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 198215003765 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 198215003766 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 198215003767 active site 198215003768 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 198215003769 hypothetical protein; Provisional; Region: PRK11630 198215003770 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 198215003771 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215003772 RNA binding surface [nucleotide binding]; other site 198215003773 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 198215003774 probable active site [active] 198215003775 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 198215003776 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 198215003777 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 198215003778 homodimer interface [polypeptide binding]; other site 198215003779 Walker A motif; other site 198215003780 ATP binding site [chemical binding]; other site 198215003781 hydroxycobalamin binding site [chemical binding]; other site 198215003782 Walker B motif; other site 198215003783 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 198215003784 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 198215003785 NADP binding site [chemical binding]; other site 198215003786 homodimer interface [polypeptide binding]; other site 198215003787 active site 198215003788 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 198215003789 putative inner membrane peptidase; Provisional; Region: PRK11778 198215003790 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 198215003791 tandem repeat interface [polypeptide binding]; other site 198215003792 oligomer interface [polypeptide binding]; other site 198215003793 active site residues [active] 198215003794 hypothetical protein; Provisional; Region: PRK11037 198215003795 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 198215003796 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 198215003797 active site 198215003798 interdomain interaction site; other site 198215003799 putative metal-binding site [ion binding]; other site 198215003800 nucleotide binding site [chemical binding]; other site 198215003801 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198215003802 domain I; other site 198215003803 DNA binding groove [nucleotide binding] 198215003804 phosphate binding site [ion binding]; other site 198215003805 domain II; other site 198215003806 domain III; other site 198215003807 nucleotide binding site [chemical binding]; other site 198215003808 catalytic site [active] 198215003809 domain IV; other site 198215003810 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198215003811 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198215003812 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 198215003813 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 198215003814 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 198215003815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215003816 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 198215003817 substrate binding site [chemical binding]; other site 198215003818 putative dimerization interface [polypeptide binding]; other site 198215003819 aconitate hydratase; Validated; Region: PRK09277 198215003820 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 198215003821 substrate binding site [chemical binding]; other site 198215003822 ligand binding site [chemical binding]; other site 198215003823 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 198215003824 substrate binding site [chemical binding]; other site 198215003825 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 198215003826 dimerization interface [polypeptide binding]; other site 198215003827 active site 198215003828 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198215003829 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 198215003830 active site 198215003831 Predicted membrane protein [Function unknown]; Region: COG3771 198215003832 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 198215003833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 198215003834 TPR motif; other site 198215003835 binding surface 198215003836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198215003837 binding surface 198215003838 TPR motif; other site 198215003839 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 198215003840 active site 198215003841 dimer interface [polypeptide binding]; other site 198215003842 translation initiation factor Sui1; Validated; Region: PRK06824 198215003843 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 198215003844 putative rRNA binding site [nucleotide binding]; other site 198215003845 lipoprotein; Provisional; Region: PRK10540 198215003846 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198215003847 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198215003848 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215003849 exoribonuclease II; Provisional; Region: PRK05054 198215003850 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198215003851 RNB domain; Region: RNB; pfam00773 198215003852 S1 RNA binding domain; Region: S1; pfam00575 198215003853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 198215003854 Uncharacterized conserved protein [Function unknown]; Region: COG2128 198215003855 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 198215003856 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 198215003857 NAD binding site [chemical binding]; other site 198215003858 homotetramer interface [polypeptide binding]; other site 198215003859 homodimer interface [polypeptide binding]; other site 198215003860 substrate binding site [chemical binding]; other site 198215003861 active site 198215003862 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 198215003863 putative active site [active] 198215003864 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 198215003865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215003866 Walker A/P-loop; other site 198215003867 ATP binding site [chemical binding]; other site 198215003868 Q-loop/lid; other site 198215003869 ABC transporter signature motif; other site 198215003870 Walker B; other site 198215003871 D-loop; other site 198215003872 H-loop/switch region; other site 198215003873 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 198215003874 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215003875 Walker A/P-loop; other site 198215003876 ATP binding site [chemical binding]; other site 198215003877 Q-loop/lid; other site 198215003878 ABC transporter signature motif; other site 198215003879 Walker B; other site 198215003880 D-loop; other site 198215003881 H-loop/switch region; other site 198215003882 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198215003883 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 198215003884 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198215003885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003886 dimer interface [polypeptide binding]; other site 198215003887 conserved gate region; other site 198215003888 putative PBP binding loops; other site 198215003889 ABC-ATPase subunit interface; other site 198215003890 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 198215003891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003892 dimer interface [polypeptide binding]; other site 198215003893 conserved gate region; other site 198215003894 putative PBP binding loops; other site 198215003895 ABC-ATPase subunit interface; other site 198215003896 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198215003897 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 198215003898 peptide binding site [polypeptide binding]; other site 198215003899 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198215003900 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 198215003901 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 198215003902 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 198215003903 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 198215003904 catalytic triad [active] 198215003905 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 198215003906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215003907 non-specific DNA binding site [nucleotide binding]; other site 198215003908 salt bridge; other site 198215003909 sequence-specific DNA binding site [nucleotide binding]; other site 198215003910 Cupin domain; Region: Cupin_2; pfam07883 198215003911 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 198215003912 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 198215003913 NAD(P) binding site [chemical binding]; other site 198215003914 catalytic residues [active] 198215003915 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 198215003916 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 198215003917 4-aminobutyrate transaminase; Provisional; Region: PRK09792 198215003918 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198215003919 inhibitor-cofactor binding pocket; inhibition site 198215003920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215003921 catalytic residue [active] 198215003922 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 198215003923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215003924 Walker A motif; other site 198215003925 ATP binding site [chemical binding]; other site 198215003926 Walker B motif; other site 198215003927 arginine finger; other site 198215003928 phage shock protein PspA; Provisional; Region: PRK10698 198215003929 phage shock protein B; Provisional; Region: pspB; PRK09458 198215003930 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 198215003931 phage shock protein C; Region: phageshock_pspC; TIGR02978 198215003932 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 198215003933 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198215003934 active site residue [active] 198215003935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215003936 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215003937 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215003938 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215003939 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 198215003940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003941 dimer interface [polypeptide binding]; other site 198215003942 conserved gate region; other site 198215003943 putative PBP binding loops; other site 198215003944 ABC-ATPase subunit interface; other site 198215003945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198215003946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215003947 dimer interface [polypeptide binding]; other site 198215003948 conserved gate region; other site 198215003949 putative PBP binding loops; other site 198215003950 ABC-ATPase subunit interface; other site 198215003951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198215003952 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 198215003953 putative NAD(P) binding site [chemical binding]; other site 198215003954 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198215003955 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198215003956 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198215003957 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 198215003958 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 198215003959 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 198215003960 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 198215003961 beta-phosphoglucomutase; Region: bPGM; TIGR01990 198215003962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215003963 motif II; other site 198215003964 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 198215003965 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198215003966 Walker A/P-loop; other site 198215003967 ATP binding site [chemical binding]; other site 198215003968 Q-loop/lid; other site 198215003969 ABC transporter signature motif; other site 198215003970 Walker B; other site 198215003971 D-loop; other site 198215003972 H-loop/switch region; other site 198215003973 TOBE domain; Region: TOBE_2; pfam08402 198215003974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198215003975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215003976 DNA binding site [nucleotide binding] 198215003977 domain linker motif; other site 198215003978 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 198215003979 putative dimerization interface [polypeptide binding]; other site 198215003980 putative ligand binding site [chemical binding]; other site 198215003981 Predicted ATPase [General function prediction only]; Region: COG3106 198215003982 Predicted membrane protein [Function unknown]; Region: COG3768 198215003983 TIGR01620 family protein; Region: hyp_HI0043 198215003984 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 198215003985 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 198215003986 putative aromatic amino acid binding site; other site 198215003987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215003988 Walker A motif; other site 198215003989 ATP binding site [chemical binding]; other site 198215003990 Walker B motif; other site 198215003991 arginine finger; other site 198215003992 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 198215003993 dimer interface [polypeptide binding]; other site 198215003994 catalytic triad [active] 198215003995 peroxidatic and resolving cysteines [active] 198215003996 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 198215003997 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 198215003998 active site 198215003999 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 198215004000 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 198215004001 putative active site [active] 198215004002 Zn binding site [ion binding]; other site 198215004003 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 198215004004 NADH(P)-binding; Region: NAD_binding_10; pfam13460 198215004005 putative NAD(P) binding site [chemical binding]; other site 198215004006 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198215004007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198215004008 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198215004009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198215004010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215004011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215004012 dimerization interface [polypeptide binding]; other site 198215004013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004014 Integrase core domain; Region: rve; pfam00665 198215004015 Integrase core domain; Region: rve_3; pfam13683 198215004016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004017 Transposase; Region: HTH_Tnp_1; pfam01527 198215004018 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 198215004019 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198215004020 peptide binding site [polypeptide binding]; other site 198215004021 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 198215004022 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198215004023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004024 Transposase; Region: HTH_Tnp_1; pfam01527 198215004025 Putative transposase; Region: Y2_Tnp; pfam04986 198215004026 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215004027 Putative transposase; Region: Y2_Tnp; pfam04986 198215004028 Integrase core domain; Region: rve; pfam00665 198215004029 universal stress protein UspE; Provisional; Region: PRK11175 198215004030 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198215004031 Ligand Binding Site [chemical binding]; other site 198215004032 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198215004033 Ligand Binding Site [chemical binding]; other site 198215004034 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 198215004035 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198215004036 ligand binding site [chemical binding]; other site 198215004037 flexible hinge region; other site 198215004038 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 198215004039 putative switch regulator; other site 198215004040 non-specific DNA interactions [nucleotide binding]; other site 198215004041 DNA binding site [nucleotide binding] 198215004042 sequence specific DNA binding site [nucleotide binding]; other site 198215004043 putative cAMP binding site [chemical binding]; other site 198215004044 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 198215004045 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 198215004046 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198215004047 DNA binding site [nucleotide binding] 198215004048 active site 198215004049 Helix-turn-helix domain; Region: HTH_18; pfam12833 198215004050 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 198215004051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215004052 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215004053 Putative transposase; Region: Y2_Tnp; pfam04986 198215004054 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 198215004055 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215004056 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 198215004057 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 198215004058 Cl binding site [ion binding]; other site 198215004059 oligomer interface [polypeptide binding]; other site 198215004060 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 198215004061 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198215004062 ATP binding site [chemical binding]; other site 198215004063 Mg++ binding site [ion binding]; other site 198215004064 motif III; other site 198215004065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215004066 nucleotide binding region [chemical binding]; other site 198215004067 ATP-binding site [chemical binding]; other site 198215004068 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 198215004069 putative RNA binding site [nucleotide binding]; other site 198215004070 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 198215004071 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 198215004072 Ligand Binding Site [chemical binding]; other site 198215004073 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198215004074 Ligand Binding Site [chemical binding]; other site 198215004075 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 198215004076 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 198215004077 dimer interface [polypeptide binding]; other site 198215004078 PYR/PP interface [polypeptide binding]; other site 198215004079 TPP binding site [chemical binding]; other site 198215004080 substrate binding site [chemical binding]; other site 198215004081 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 198215004082 Domain of unknown function; Region: EKR; smart00890 198215004083 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198215004084 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 198215004085 TPP-binding site [chemical binding]; other site 198215004086 dimer interface [polypeptide binding]; other site 198215004087 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004089 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004090 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 198215004092 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 198215004093 hypothetical protein; Provisional; Region: PRK10695 198215004094 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 198215004095 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 198215004096 putative ligand binding site [chemical binding]; other site 198215004097 putative NAD binding site [chemical binding]; other site 198215004098 catalytic site [active] 198215004099 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004101 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004102 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004103 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 198215004104 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 198215004105 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 198215004106 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 198215004107 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 198215004108 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198215004109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215004110 S-adenosylmethionine binding site [chemical binding]; other site 198215004111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004112 Integrase core domain; Region: rve; pfam00665 198215004113 Integrase core domain; Region: rve_3; pfam13683 198215004114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004115 Transposase; Region: HTH_Tnp_1; pfam01527 198215004116 azoreductase; Reviewed; Region: PRK00170 198215004117 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198215004118 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 198215004119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215004120 ATP binding site [chemical binding]; other site 198215004121 putative Mg++ binding site [ion binding]; other site 198215004122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215004123 nucleotide binding region [chemical binding]; other site 198215004124 ATP-binding site [chemical binding]; other site 198215004125 Helicase associated domain (HA2); Region: HA2; pfam04408 198215004126 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 198215004127 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 198215004128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004129 Integrase core domain; Region: rve; pfam00665 198215004130 Integrase core domain; Region: rve_3; pfam13683 198215004131 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 198215004132 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 198215004133 NAD binding site [chemical binding]; other site 198215004134 catalytic residues [active] 198215004135 substrate binding site [chemical binding]; other site 198215004136 cytochrome b561; Provisional; Region: PRK11513 198215004137 hypothetical protein; Provisional; Region: PRK10040 198215004138 putative transposase OrfB; Reviewed; Region: PHA02517 198215004139 HTH-like domain; Region: HTH_21; pfam13276 198215004140 Integrase core domain; Region: rve; pfam00665 198215004141 Integrase core domain; Region: rve_2; pfam13333 198215004142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004143 Helix-turn-helix domain; Region: HTH_28; pfam13518 198215004144 Helix-turn-helix domain; Region: HTH_28; pfam13518 198215004145 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 198215004146 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198215004147 dimer interface [polypeptide binding]; other site 198215004148 ligand binding site [chemical binding]; other site 198215004149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215004150 dimerization interface [polypeptide binding]; other site 198215004151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198215004152 dimer interface [polypeptide binding]; other site 198215004153 putative CheW interface [polypeptide binding]; other site 198215004154 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 198215004155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215004156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215004157 dimerization interface [polypeptide binding]; other site 198215004158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 198215004159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 198215004160 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 198215004161 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 198215004162 hypothetical protein; Provisional; Region: PRK11415 198215004163 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198215004164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215004165 Coenzyme A binding pocket [chemical binding]; other site 198215004166 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 198215004167 putative trimer interface [polypeptide binding]; other site 198215004168 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 198215004169 putative CoA binding site [chemical binding]; other site 198215004170 putative trimer interface [polypeptide binding]; other site 198215004171 putative CoA binding site [chemical binding]; other site 198215004172 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 198215004173 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 198215004174 gating phenylalanine in ion channel; other site 198215004175 tellurite resistance protein TehB; Provisional; Region: PRK11207 198215004176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215004177 S-adenosylmethionine binding site [chemical binding]; other site 198215004178 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 198215004179 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215004180 Putative transposase; Region: Y2_Tnp; pfam04986 198215004181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004182 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004183 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004184 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004186 Transposase; Region: HTH_Tnp_1; pfam01527 198215004187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004188 Integrase core domain; Region: rve; pfam00665 198215004189 Integrase core domain; Region: rve_3; pfam13683 198215004190 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 198215004191 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 198215004192 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 198215004193 Paraquat-inducible protein A; Region: PqiA; pfam04403 198215004194 Paraquat-inducible protein A; Region: PqiA; pfam04403 198215004195 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 198215004196 GAF domain; Region: GAF_2; pfam13185 198215004197 ProP expression regulator; Provisional; Region: PRK04950 198215004198 carboxy-terminal protease; Provisional; Region: PRK11186 198215004199 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 198215004200 protein binding site [polypeptide binding]; other site 198215004201 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 198215004202 Catalytic dyad [active] 198215004203 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 198215004204 heat shock protein HtpX; Provisional; Region: PRK05457 198215004205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198215004207 putative substrate translocation pore; other site 198215004208 Predicted integral membrane protein [Function unknown]; Region: COG5521 198215004209 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 198215004210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215004211 dimerization interface [polypeptide binding]; other site 198215004212 putative Zn2+ binding site [ion binding]; other site 198215004213 putative DNA binding site [nucleotide binding]; other site 198215004214 Bacterial transcriptional regulator; Region: IclR; pfam01614 198215004215 PhoPQ regulatory protein; Provisional; Region: PRK10299 198215004216 YebO-like protein; Region: YebO; pfam13974 198215004217 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 198215004218 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198215004219 DNA-binding site [nucleotide binding]; DNA binding site 198215004220 RNA-binding motif; other site 198215004221 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 198215004222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215004223 S-adenosylmethionine binding site [chemical binding]; other site 198215004224 hypothetical protein; Provisional; Region: PRK11469 198215004225 Domain of unknown function DUF; Region: DUF204; pfam02659 198215004226 Domain of unknown function DUF; Region: DUF204; pfam02659 198215004227 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004229 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004230 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004231 Predicted membrane protein [Function unknown]; Region: COG4811 198215004232 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 198215004233 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 198215004234 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 198215004235 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198215004236 active pocket/dimerization site; other site 198215004237 active site 198215004238 phosphorylation site [posttranslational modification] 198215004239 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 198215004240 active site 198215004241 phosphorylation site [posttranslational modification] 198215004242 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198215004243 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198215004244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198215004245 Transporter associated domain; Region: CorC_HlyC; smart01091 198215004246 phage resistance protein; Provisional; Region: PRK10551 198215004247 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198215004248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198215004249 L-serine deaminase; Provisional; Region: PRK15023 198215004250 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198215004251 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198215004252 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 198215004253 putative active site [active] 198215004254 putative CoA binding site [chemical binding]; other site 198215004255 nudix motif; other site 198215004256 metal binding site [ion binding]; metal-binding site 198215004257 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 198215004258 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198215004259 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 198215004260 hypothetical protein; Provisional; Region: PRK05114 198215004261 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 198215004262 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 198215004263 homotrimer interaction site [polypeptide binding]; other site 198215004264 putative active site [active] 198215004265 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 198215004266 DEAD/DEAH box helicase; Region: DEAD; pfam00270 198215004267 DEAD_2; Region: DEAD_2; pfam06733 198215004268 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198215004269 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 198215004270 Glycoprotease family; Region: Peptidase_M22; pfam00814 198215004271 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 198215004272 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 198215004273 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 198215004274 acyl-activating enzyme (AAE) consensus motif; other site 198215004275 putative AMP binding site [chemical binding]; other site 198215004276 putative active site [active] 198215004277 putative CoA binding site [chemical binding]; other site 198215004278 ribonuclease D; Provisional; Region: PRK10829 198215004279 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 198215004280 catalytic site [active] 198215004281 putative active site [active] 198215004282 putative substrate binding site [chemical binding]; other site 198215004283 Helicase and RNase D C-terminal; Region: HRDC; smart00341 198215004284 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 198215004285 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 198215004286 FMN-binding pocket [chemical binding]; other site 198215004287 flavin binding motif; other site 198215004288 phosphate binding motif [ion binding]; other site 198215004289 beta-alpha-beta structure motif; other site 198215004290 NAD binding pocket [chemical binding]; other site 198215004291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198215004292 catalytic loop [active] 198215004293 iron binding site [ion binding]; other site 198215004294 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198215004295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215004296 non-specific DNA binding site [nucleotide binding]; other site 198215004297 salt bridge; other site 198215004298 sequence-specific DNA binding site [nucleotide binding]; other site 198215004299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004300 Transposase; Region: HTH_Tnp_1; pfam01527 198215004301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004302 Integrase core domain; Region: rve; pfam00665 198215004303 Integrase core domain; Region: rve_3; pfam13683 198215004304 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 198215004305 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198215004306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198215004307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198215004308 metal binding site [ion binding]; metal-binding site 198215004309 active site 198215004310 I-site; other site 198215004311 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 198215004312 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 198215004313 Domain of unknown function (DUF333); Region: DUF333; pfam03891 198215004314 Uncharacterized conserved protein [Function unknown]; Region: COG3189 198215004315 cyanate transporter; Region: CynX; TIGR00896 198215004316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004317 putative substrate translocation pore; other site 198215004318 Predicted membrane protein [Function unknown]; Region: COG2707 198215004319 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 198215004320 putative deacylase active site [active] 198215004321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004322 Integrase core domain; Region: rve; pfam00665 198215004323 Integrase core domain; Region: rve_3; pfam13683 198215004324 PrkA AAA domain; Region: AAA_PrkA; pfam08298 198215004325 AAA ATPase domain; Region: AAA_16; pfam13191 198215004326 Walker A motif; other site 198215004327 ATP binding site [chemical binding]; other site 198215004328 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 198215004329 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 198215004330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198215004331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198215004332 active site 198215004333 catalytic tetrad [active] 198215004334 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 198215004335 active site 198215004336 phosphate binding residues; other site 198215004337 catalytic residues [active] 198215004338 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 198215004339 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198215004340 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198215004341 methionine sulfoxide reductase B; Provisional; Region: PRK00222 198215004342 SelR domain; Region: SelR; pfam01641 198215004343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 198215004344 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198215004345 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 198215004346 putative NAD(P) binding site [chemical binding]; other site 198215004347 catalytic Zn binding site [ion binding]; other site 198215004348 structural Zn binding site [ion binding]; other site 198215004349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004351 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 198215004352 intersubunit interface [polypeptide binding]; other site 198215004353 active site 198215004354 zinc binding site [ion binding]; other site 198215004355 Na+ binding site [ion binding]; other site 198215004356 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215004357 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198215004358 substrate binding site [chemical binding]; other site 198215004359 ATP binding site [chemical binding]; other site 198215004360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198215004361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198215004362 active site 198215004363 catalytic tetrad [active] 198215004364 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198215004365 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198215004366 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215004367 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 198215004368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004369 putative substrate translocation pore; other site 198215004370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004371 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 198215004372 Isochorismatase family; Region: Isochorismatase; pfam00857 198215004373 catalytic triad [active] 198215004374 metal binding site [ion binding]; metal-binding site 198215004375 conserved cis-peptide bond; other site 198215004376 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 198215004377 active site 198215004378 homodimer interface [polypeptide binding]; other site 198215004379 protease 4; Provisional; Region: PRK10949 198215004380 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 198215004381 tandem repeat interface [polypeptide binding]; other site 198215004382 oligomer interface [polypeptide binding]; other site 198215004383 active site residues [active] 198215004384 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 198215004385 tandem repeat interface [polypeptide binding]; other site 198215004386 oligomer interface [polypeptide binding]; other site 198215004387 active site residues [active] 198215004388 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 198215004389 putative FMN binding site [chemical binding]; other site 198215004390 selenophosphate synthetase; Provisional; Region: PRK00943 198215004391 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 198215004392 dimerization interface [polypeptide binding]; other site 198215004393 putative ATP binding site [chemical binding]; other site 198215004394 DNA topoisomerase III; Provisional; Region: PRK07726 198215004395 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 198215004396 active site 198215004397 putative interdomain interaction site [polypeptide binding]; other site 198215004398 putative metal-binding site [ion binding]; other site 198215004399 putative nucleotide binding site [chemical binding]; other site 198215004400 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198215004401 domain I; other site 198215004402 DNA binding groove [nucleotide binding] 198215004403 phosphate binding site [ion binding]; other site 198215004404 domain II; other site 198215004405 domain III; other site 198215004406 nucleotide binding site [chemical binding]; other site 198215004407 catalytic site [active] 198215004408 domain IV; other site 198215004409 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215004410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004411 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215004412 HTH-like domain; Region: HTH_21; pfam13276 198215004413 Integrase core domain; Region: rve; pfam00665 198215004414 Integrase core domain; Region: rve_3; pfam13683 198215004415 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 198215004416 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 198215004417 active site 198215004418 8-oxo-dGMP binding site [chemical binding]; other site 198215004419 nudix motif; other site 198215004420 metal binding site [ion binding]; metal-binding site 198215004421 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 198215004422 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 198215004423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215004424 Walker A/P-loop; other site 198215004425 ATP binding site [chemical binding]; other site 198215004426 Q-loop/lid; other site 198215004427 ABC transporter signature motif; other site 198215004428 Walker B; other site 198215004429 D-loop; other site 198215004430 H-loop/switch region; other site 198215004431 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215004432 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215004433 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215004434 Uncharacterized conserved protein [Function unknown]; Region: COG2128 198215004435 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 198215004436 Uncharacterized conserved protein [Function unknown]; Region: COG0398 198215004437 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 198215004438 Uncharacterized conserved protein [Function unknown]; Region: COG0398 198215004439 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 198215004440 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 198215004441 putative catalytic site [active] 198215004442 putative phosphate binding site [ion binding]; other site 198215004443 active site 198215004444 metal binding site A [ion binding]; metal-binding site 198215004445 DNA binding site [nucleotide binding] 198215004446 putative AP binding site [nucleotide binding]; other site 198215004447 putative metal binding site B [ion binding]; other site 198215004448 arginine succinyltransferase; Provisional; Region: PRK10456 198215004449 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 198215004450 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 198215004451 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 198215004452 NAD(P) binding site [chemical binding]; other site 198215004453 catalytic residues [active] 198215004454 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 198215004455 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 198215004456 putative active site [active] 198215004457 Zn binding site [ion binding]; other site 198215004458 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 198215004459 dimer interface [polypeptide binding]; other site 198215004460 hypothetical protein; Provisional; Region: PRK11396 198215004461 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 198215004462 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198215004463 GIY-YIG motif/motif A; other site 198215004464 active site 198215004465 catalytic site [active] 198215004466 putative DNA binding site [nucleotide binding]; other site 198215004467 metal binding site [ion binding]; metal-binding site 198215004468 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 198215004469 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 198215004470 homodimer interface [polypeptide binding]; other site 198215004471 NAD binding pocket [chemical binding]; other site 198215004472 ATP binding pocket [chemical binding]; other site 198215004473 Mg binding site [ion binding]; other site 198215004474 active-site loop [active] 198215004475 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 198215004476 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 198215004477 active site 198215004478 P-loop; other site 198215004479 phosphorylation site [posttranslational modification] 198215004480 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 198215004481 methionine cluster; other site 198215004482 active site 198215004483 phosphorylation site [posttranslational modification] 198215004484 metal binding site [ion binding]; metal-binding site 198215004485 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004487 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004488 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004489 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 198215004490 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 198215004491 NAD binding site [chemical binding]; other site 198215004492 sugar binding site [chemical binding]; other site 198215004493 divalent metal binding site [ion binding]; other site 198215004494 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198215004495 dimer interface [polypeptide binding]; other site 198215004496 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 198215004497 putative active site [active] 198215004498 YdjC motif; other site 198215004499 Mg binding site [ion binding]; other site 198215004500 putative homodimer interface [polypeptide binding]; other site 198215004501 hydroperoxidase II; Provisional; Region: katE; PRK11249 198215004502 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 198215004503 tetramer interface [polypeptide binding]; other site 198215004504 heme binding pocket [chemical binding]; other site 198215004505 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 198215004506 domain interactions; other site 198215004507 cell division modulator; Provisional; Region: PRK10113 198215004508 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004510 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004511 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004512 inner membrane protein; Provisional; Region: PRK11648 198215004513 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 198215004514 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198215004515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215004516 motif II; other site 198215004517 YniB-like protein; Region: YniB; pfam14002 198215004518 Phosphotransferase enzyme family; Region: APH; pfam01636 198215004519 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 198215004520 active site 198215004521 ATP binding site [chemical binding]; other site 198215004522 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198215004523 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 198215004524 6-phosphofructokinase 2; Provisional; Region: PRK10294 198215004525 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 198215004526 putative substrate binding site [chemical binding]; other site 198215004527 putative ATP binding site [chemical binding]; other site 198215004528 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 198215004529 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004531 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004532 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004533 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 198215004534 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 198215004535 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 198215004536 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 198215004537 active site 198215004538 dimer interface [polypeptide binding]; other site 198215004539 motif 1; other site 198215004540 motif 2; other site 198215004541 motif 3; other site 198215004542 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 198215004543 anticodon binding site; other site 198215004544 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 198215004545 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 198215004546 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 198215004547 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 198215004548 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 198215004549 23S rRNA binding site [nucleotide binding]; other site 198215004550 L21 binding site [polypeptide binding]; other site 198215004551 L13 binding site [polypeptide binding]; other site 198215004552 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 198215004553 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 198215004554 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 198215004555 dimer interface [polypeptide binding]; other site 198215004556 motif 1; other site 198215004557 active site 198215004558 motif 2; other site 198215004559 motif 3; other site 198215004560 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 198215004561 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 198215004562 putative tRNA-binding site [nucleotide binding]; other site 198215004563 B3/4 domain; Region: B3_4; pfam03483 198215004564 tRNA synthetase B5 domain; Region: B5; smart00874 198215004565 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 198215004566 dimer interface [polypeptide binding]; other site 198215004567 motif 1; other site 198215004568 motif 3; other site 198215004569 motif 2; other site 198215004570 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 198215004571 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198215004572 IHF dimer interface [polypeptide binding]; other site 198215004573 IHF - DNA interface [nucleotide binding]; other site 198215004574 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198215004575 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215004576 ABC-ATPase subunit interface; other site 198215004577 dimer interface [polypeptide binding]; other site 198215004578 putative PBP binding regions; other site 198215004579 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 198215004580 catalytic residues [active] 198215004581 dimer interface [polypeptide binding]; other site 198215004582 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 198215004583 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198215004584 Walker A/P-loop; other site 198215004585 ATP binding site [chemical binding]; other site 198215004586 Q-loop/lid; other site 198215004587 ABC transporter signature motif; other site 198215004588 Walker B; other site 198215004589 D-loop; other site 198215004590 H-loop/switch region; other site 198215004591 NlpC/P60 family; Region: NLPC_P60; pfam00877 198215004592 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 198215004593 Uncharacterized conserved protein [Function unknown]; Region: COG0397 198215004594 hypothetical protein; Validated; Region: PRK00029 198215004595 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 198215004596 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 198215004597 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198215004598 PEP synthetase regulatory protein; Provisional; Region: PRK05339 198215004599 phosphoenolpyruvate synthase; Validated; Region: PRK06464 198215004600 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 198215004601 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198215004602 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198215004603 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 198215004604 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 198215004605 acyl-activating enzyme (AAE) consensus motif; other site 198215004606 putative AMP binding site [chemical binding]; other site 198215004607 putative active site [active] 198215004608 putative CoA binding site [chemical binding]; other site 198215004609 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 198215004610 oxidoreductase; Provisional; Region: PRK10015 198215004611 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 198215004612 Electron transfer flavoprotein domain; Region: ETF; smart00893 198215004613 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 198215004614 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 198215004615 Ligand binding site [chemical binding]; other site 198215004616 Electron transfer flavoprotein domain; Region: ETF; pfam01012 198215004617 Cupin domain; Region: Cupin_2; pfam07883 198215004618 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004619 transcriptional regulator YdeO; Provisional; Region: PRK09940 198215004620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215004621 putative oxidoreductase; Provisional; Region: PRK09939 198215004622 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 198215004623 putative molybdopterin cofactor binding site [chemical binding]; other site 198215004624 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 198215004625 putative molybdopterin cofactor binding site; other site 198215004626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004627 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004628 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004629 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004631 Integrase core domain; Region: rve; pfam00665 198215004632 Integrase core domain; Region: rve_3; pfam13683 198215004633 Lysis protein S; Region: Lysis_S; pfam04971 198215004634 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 198215004635 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 198215004636 Hok/gef family; Region: HOK_GEF; pfam01848 198215004637 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 198215004638 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 198215004639 Integrase core domain; Region: rve; pfam00665 198215004640 Integrase core domain; Region: rve_3; pfam13683 198215004641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004642 Transposase; Region: HTH_Tnp_1; pfam01527 198215004643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004644 Integrase core domain; Region: rve; pfam00665 198215004645 Integrase core domain; Region: rve_3; pfam13683 198215004646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004647 Transposase; Region: HTH_Tnp_1; pfam01527 198215004648 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 198215004649 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198215004650 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198215004651 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 198215004652 Transcriptional regulators [Transcription]; Region: GntR; COG1802 198215004653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215004654 DNA-binding site [nucleotide binding]; DNA binding site 198215004655 FCD domain; Region: FCD; pfam07729 198215004656 malonic semialdehyde reductase; Provisional; Region: PRK10538 198215004657 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 198215004658 putative NAD(P) binding site [chemical binding]; other site 198215004659 homodimer interface [polypeptide binding]; other site 198215004660 homotetramer interface [polypeptide binding]; other site 198215004661 active site 198215004662 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 198215004663 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 198215004664 active site 198215004665 Zn binding site [ion binding]; other site 198215004666 hypothetical protein; Validated; Region: PRK03657 198215004667 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 198215004668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004669 Transposase; Region: HTH_Tnp_1; pfam01527 198215004670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215004671 Integrase core domain; Region: rve; pfam00665 198215004672 Integrase core domain; Region: rve_3; pfam13683 198215004673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004674 putative substrate translocation pore; other site 198215004675 putative transporter; Provisional; Region: PRK10054 198215004676 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 198215004677 EamA-like transporter family; Region: EamA; pfam00892 198215004678 EamA-like transporter family; Region: EamA; pfam00892 198215004679 hypothetical protein; Provisional; Region: PRK10106 198215004680 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 198215004681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215004682 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 198215004683 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198215004684 inner membrane protein; Provisional; Region: PRK10995 198215004685 putative arabinose transporter; Provisional; Region: PRK03545 198215004686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004687 putative substrate translocation pore; other site 198215004688 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 198215004689 glutaminase; Provisional; Region: PRK00971 198215004690 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 198215004691 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198215004692 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198215004693 metal binding site [ion binding]; metal-binding site 198215004694 active site 198215004695 I-site; other site 198215004696 altronate oxidoreductase; Provisional; Region: PRK03643 198215004697 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198215004698 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198215004699 Predicted membrane protein [Function unknown]; Region: COG3781 198215004700 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 198215004701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215004702 S-adenosylmethionine binding site [chemical binding]; other site 198215004703 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 198215004704 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 198215004705 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 198215004706 putative active site; other site 198215004707 catalytic residue [active] 198215004708 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215004709 HTH-like domain; Region: HTH_21; pfam13276 198215004710 Integrase core domain; Region: rve; pfam00665 198215004711 Integrase core domain; Region: rve_3; pfam13683 198215004712 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215004713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004714 Dif; recA-independent recombination site in terminus of chromosome replication 198215004715 transcriptional regulator LsrR; Provisional; Region: PRK15418 198215004716 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 198215004717 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 198215004718 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 198215004719 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198215004720 Walker A/P-loop; other site 198215004721 ATP binding site [chemical binding]; other site 198215004722 Q-loop/lid; other site 198215004723 ABC transporter signature motif; other site 198215004724 Walker B; other site 198215004725 D-loop; other site 198215004726 H-loop/switch region; other site 198215004727 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198215004728 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215004729 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215004730 TM-ABC transporter signature motif; other site 198215004731 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215004732 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215004733 TM-ABC transporter signature motif; other site 198215004734 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215004735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004736 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215004737 HTH-like domain; Region: HTH_21; pfam13276 198215004738 Integrase core domain; Region: rve; pfam00665 198215004739 Integrase core domain; Region: rve_3; pfam13683 198215004740 putative transposase OrfB; Reviewed; Region: PHA02517 198215004741 HTH-like domain; Region: HTH_21; pfam13276 198215004742 Integrase core domain; Region: rve; pfam00665 198215004743 Integrase core domain; Region: rve_2; pfam13333 198215004744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004745 Transposase; Region: HTH_Tnp_1; pfam01527 198215004746 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 198215004747 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 198215004748 putative active site pocket [active] 198215004749 putative metal binding site [ion binding]; other site 198215004750 hypothetical protein; Provisional; Region: PRK02237 198215004751 hypothetical protein; Provisional; Region: PRK13659 198215004752 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 198215004753 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 198215004754 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 198215004755 Integrase core domain; Region: rve; pfam00665 198215004756 Integrase core domain; Region: rve_3; pfam13683 198215004757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004758 Transposase; Region: HTH_Tnp_1; pfam01527 198215004759 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 198215004760 4Fe-4S binding domain; Region: Fer4; cl02805 198215004761 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 198215004762 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 198215004763 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 198215004764 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 198215004765 Cl- selectivity filter; other site 198215004766 Cl- binding residues [ion binding]; other site 198215004767 pore gating glutamate residue; other site 198215004768 dimer interface [polypeptide binding]; other site 198215004769 putative dithiobiotin synthetase; Provisional; Region: PRK12374 198215004770 AAA domain; Region: AAA_26; pfam13500 198215004771 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 198215004772 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198215004773 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198215004774 nucleotide binding site [chemical binding]; other site 198215004775 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 198215004776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215004777 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 198215004778 dimerization interface [polypeptide binding]; other site 198215004779 substrate binding pocket [chemical binding]; other site 198215004780 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 198215004781 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 198215004782 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 198215004783 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 198215004784 Domain of unknown function DUF20; Region: UPF0118; pfam01594 198215004785 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 198215004786 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 198215004787 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 198215004788 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 198215004789 ligand binding site [chemical binding]; other site 198215004790 homodimer interface [polypeptide binding]; other site 198215004791 NAD(P) binding site [chemical binding]; other site 198215004792 trimer interface B [polypeptide binding]; other site 198215004793 trimer interface A [polypeptide binding]; other site 198215004794 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 198215004795 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198215004796 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198215004797 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198215004798 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 198215004799 Spore germination protein; Region: Spore_permease; cl17796 198215004800 dihydromonapterin reductase; Provisional; Region: PRK06483 198215004801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198215004802 NAD(P) binding site [chemical binding]; other site 198215004803 active site 198215004804 GlpM protein; Region: GlpM; pfam06942 198215004805 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 198215004806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215004807 active site 198215004808 phosphorylation site [posttranslational modification] 198215004809 intermolecular recognition site; other site 198215004810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215004811 DNA binding site [nucleotide binding] 198215004812 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 198215004813 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198215004814 sensor protein RstB; Provisional; Region: PRK10604 198215004815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215004816 dimerization interface [polypeptide binding]; other site 198215004817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215004818 dimer interface [polypeptide binding]; other site 198215004819 phosphorylation site [posttranslational modification] 198215004820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215004821 ATP binding site [chemical binding]; other site 198215004822 Mg2+ binding site [ion binding]; other site 198215004823 G-X-G motif; other site 198215004824 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 198215004825 fumarate hydratase; Reviewed; Region: fumC; PRK00485 198215004826 Class II fumarases; Region: Fumarase_classII; cd01362 198215004827 active site 198215004828 tetramer interface [polypeptide binding]; other site 198215004829 fumarate hydratase; Provisional; Region: PRK15389 198215004830 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 198215004831 Fumarase C-terminus; Region: Fumerase_C; pfam05683 198215004832 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 198215004833 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 198215004834 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 198215004835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 198215004836 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 198215004837 putative outer membrane porin protein; Provisional; Region: PRK11379 198215004838 beta-D-glucuronidase; Provisional; Region: PRK10150 198215004839 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 198215004840 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 198215004841 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 198215004842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198215004843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215004844 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215004845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215004846 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215004847 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215004848 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 198215004849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215004850 DNA binding site [nucleotide binding] 198215004851 domain linker motif; other site 198215004852 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 198215004853 putative dimerization interface [polypeptide binding]; other site 198215004854 putative ligand binding site [chemical binding]; other site 198215004855 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 198215004856 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 198215004857 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198215004858 active site turn [active] 198215004859 phosphorylation site [posttranslational modification] 198215004860 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 198215004861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215004862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215004863 homodimer interface [polypeptide binding]; other site 198215004864 catalytic residue [active] 198215004865 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 198215004866 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 198215004867 active site 198215004868 purine riboside binding site [chemical binding]; other site 198215004869 putative oxidoreductase; Provisional; Region: PRK11579 198215004870 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198215004871 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198215004872 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 198215004873 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 198215004874 electron transport complex protein RsxA; Provisional; Region: PRK05151 198215004875 electron transport complex protein RnfB; Provisional; Region: PRK05113 198215004876 Putative Fe-S cluster; Region: FeS; pfam04060 198215004877 4Fe-4S binding domain; Region: Fer4; pfam00037 198215004878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 198215004879 SLBB domain; Region: SLBB; pfam10531 198215004880 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198215004881 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 198215004882 electron transport complex protein RnfG; Validated; Region: PRK01908 198215004883 electron transport complex RsxE subunit; Provisional; Region: PRK12405 198215004884 endonuclease III; Provisional; Region: PRK10702 198215004885 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198215004886 minor groove reading motif; other site 198215004887 helix-hairpin-helix signature motif; other site 198215004888 substrate binding pocket [chemical binding]; other site 198215004889 active site 198215004890 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 198215004891 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 198215004892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004893 putative substrate translocation pore; other site 198215004894 POT family; Region: PTR2; pfam00854 198215004895 glutathionine S-transferase; Provisional; Region: PRK10542 198215004896 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 198215004897 C-terminal domain interface [polypeptide binding]; other site 198215004898 GSH binding site (G-site) [chemical binding]; other site 198215004899 dimer interface [polypeptide binding]; other site 198215004900 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 198215004901 N-terminal domain interface [polypeptide binding]; other site 198215004902 dimer interface [polypeptide binding]; other site 198215004903 substrate binding pocket (H-site) [chemical binding]; other site 198215004904 pyridoxamine kinase; Validated; Region: PRK05756 198215004905 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 198215004906 dimer interface [polypeptide binding]; other site 198215004907 pyridoxal binding site [chemical binding]; other site 198215004908 ATP binding site [chemical binding]; other site 198215004909 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 198215004910 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 198215004911 active site 198215004912 HIGH motif; other site 198215004913 dimer interface [polypeptide binding]; other site 198215004914 KMSKS motif; other site 198215004915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215004916 RNA binding surface [nucleotide binding]; other site 198215004917 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 198215004918 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 198215004919 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 198215004920 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 198215004921 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215004922 HTH-like domain; Region: HTH_21; pfam13276 198215004923 Integrase core domain; Region: rve; pfam00665 198215004924 Integrase core domain; Region: rve_3; pfam13683 198215004925 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215004926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215004927 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 198215004928 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 198215004929 transcriptional regulator SlyA; Provisional; Region: PRK03573 198215004930 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 198215004931 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 198215004932 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 198215004933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215004934 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215004935 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 198215004936 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 198215004937 E-class dimer interface [polypeptide binding]; other site 198215004938 P-class dimer interface [polypeptide binding]; other site 198215004939 active site 198215004940 Cu2+ binding site [ion binding]; other site 198215004941 Zn2+ binding site [ion binding]; other site 198215004942 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198215004943 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198215004944 active site 198215004945 catalytic tetrad [active] 198215004946 Predicted Fe-S protein [General function prediction only]; Region: COG3313 198215004947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198215004948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215004949 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 198215004950 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 198215004951 FMN binding site [chemical binding]; other site 198215004952 active site 198215004953 substrate binding site [chemical binding]; other site 198215004954 catalytic residue [active] 198215004955 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198215004956 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 198215004957 dimer interface [polypeptide binding]; other site 198215004958 active site 198215004959 metal binding site [ion binding]; metal-binding site 198215004960 glutathione binding site [chemical binding]; other site 198215004961 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 198215004962 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 198215004963 dimer interface [polypeptide binding]; other site 198215004964 catalytic site [active] 198215004965 putative active site [active] 198215004966 putative substrate binding site [chemical binding]; other site 198215004967 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 198215004968 Probable transposase; Region: OrfB_IS605; pfam01385 198215004969 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 198215004970 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 198215004971 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 198215004972 putative GSH binding site [chemical binding]; other site 198215004973 catalytic residues [active] 198215004974 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198215004975 NlpC/P60 family; Region: NLPC_P60; pfam00877 198215004976 superoxide dismutase; Provisional; Region: PRK10543 198215004977 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198215004978 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198215004979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004980 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198215004981 putative substrate translocation pore; other site 198215004982 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 198215004983 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215004984 DNA binding site [nucleotide binding] 198215004985 domain linker motif; other site 198215004986 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 198215004987 dimerization interface [polypeptide binding]; other site 198215004988 ligand binding site [chemical binding]; other site 198215004989 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 198215004990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215004991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215004992 dimerization interface [polypeptide binding]; other site 198215004993 putative transporter; Provisional; Region: PRK11043 198215004994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215004995 putative substrate translocation pore; other site 198215004996 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 198215004997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198215004998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215004999 S-adenosylmethionine binding site [chemical binding]; other site 198215005000 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 198215005001 Lumazine binding domain; Region: Lum_binding; pfam00677 198215005002 Lumazine binding domain; Region: Lum_binding; pfam00677 198215005003 multidrug efflux protein; Reviewed; Region: PRK01766 198215005004 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 198215005005 cation binding site [ion binding]; other site 198215005006 hypothetical protein; Provisional; Region: PRK09945 198215005007 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 198215005008 putative monooxygenase; Provisional; Region: PRK11118 198215005009 hypothetical protein; Provisional; Region: PRK09946 198215005010 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 198215005011 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 198215005012 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 198215005013 hypothetical protein; Provisional; Region: PRK09947 198215005014 hypothetical protein; Provisional; Region: PRK09898 198215005015 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198215005016 hypothetical protein; Provisional; Region: PRK10292 198215005017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005018 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005019 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005020 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005021 pyruvate kinase; Provisional; Region: PRK09206 198215005022 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 198215005023 domain interfaces; other site 198215005024 active site 198215005025 murein lipoprotein; Provisional; Region: PRK15396 198215005026 L,D-transpeptidase; Provisional; Region: PRK10190 198215005027 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215005028 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198215005029 cysteine desufuration protein SufE; Provisional; Region: PRK09296 198215005030 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 198215005031 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 198215005032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198215005033 catalytic residue [active] 198215005034 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 198215005035 FeS assembly protein SufD; Region: sufD; TIGR01981 198215005036 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 198215005037 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 198215005038 Walker A/P-loop; other site 198215005039 ATP binding site [chemical binding]; other site 198215005040 Q-loop/lid; other site 198215005041 ABC transporter signature motif; other site 198215005042 Walker B; other site 198215005043 D-loop; other site 198215005044 H-loop/switch region; other site 198215005045 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 198215005046 putative ABC transporter; Region: ycf24; CHL00085 198215005047 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 198215005048 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198215005049 CoenzymeA binding site [chemical binding]; other site 198215005050 subunit interaction site [polypeptide binding]; other site 198215005051 PHB binding site; other site 198215005052 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 198215005053 FAD binding domain; Region: FAD_binding_4; pfam01565 198215005054 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198215005055 putative inner membrane protein; Provisional; Region: PRK10983 198215005056 Domain of unknown function DUF20; Region: UPF0118; pfam01594 198215005057 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 198215005058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215005059 putative substrate translocation pore; other site 198215005060 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198215005061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215005062 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198215005063 putative substrate translocation pore; other site 198215005064 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 198215005065 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 198215005066 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 198215005067 shikimate binding site; other site 198215005068 NAD(P) binding site [chemical binding]; other site 198215005069 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 198215005070 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 198215005071 active site 198215005072 catalytic residue [active] 198215005073 dimer interface [polypeptide binding]; other site 198215005074 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005076 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005077 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005078 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 198215005079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215005080 FeS/SAM binding site; other site 198215005081 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 198215005082 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 198215005083 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 198215005084 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005086 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005087 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005089 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005090 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005091 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005092 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 198215005093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215005094 catalytic residue [active] 198215005095 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 198215005096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 198215005097 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 198215005098 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 198215005099 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198215005100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215005101 dimer interface [polypeptide binding]; other site 198215005102 conserved gate region; other site 198215005103 putative PBP binding loops; other site 198215005104 ABC-ATPase subunit interface; other site 198215005105 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198215005106 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215005107 Walker A/P-loop; other site 198215005108 ATP binding site [chemical binding]; other site 198215005109 Q-loop/lid; other site 198215005110 ABC transporter signature motif; other site 198215005111 Walker B; other site 198215005112 D-loop; other site 198215005113 H-loop/switch region; other site 198215005114 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198215005115 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 198215005116 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005118 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005119 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005120 malate dehydrogenase; Provisional; Region: PRK13529 198215005121 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198215005122 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 198215005123 NAD(P) binding site [chemical binding]; other site 198215005124 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 198215005125 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 198215005126 NAD binding site [chemical binding]; other site 198215005127 substrate binding site [chemical binding]; other site 198215005128 catalytic Zn binding site [ion binding]; other site 198215005129 tetramer interface [polypeptide binding]; other site 198215005130 structural Zn binding site [ion binding]; other site 198215005131 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 198215005132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215005133 non-specific DNA binding site [nucleotide binding]; other site 198215005134 salt bridge; other site 198215005135 sequence-specific DNA binding site [nucleotide binding]; other site 198215005136 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 198215005137 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 198215005138 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 198215005139 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 198215005140 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 198215005141 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198215005142 [4Fe-4S] binding site [ion binding]; other site 198215005143 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198215005144 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198215005145 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 198215005146 molybdopterin cofactor binding site; other site 198215005147 aromatic amino acid exporter; Provisional; Region: PRK11689 198215005148 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198215005149 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198215005150 trimer interface [polypeptide binding]; other site 198215005151 eyelet of channel; other site 198215005152 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198215005153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005154 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005155 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005156 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005157 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 198215005158 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215005159 Putative transposase; Region: Y2_Tnp; pfam04986 198215005160 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 198215005161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215005162 DNA-binding site [nucleotide binding]; DNA binding site 198215005163 FCD domain; Region: FCD; pfam07729 198215005164 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 198215005165 Prostaglandin dehydrogenases; Region: PGDH; cd05288 198215005166 NAD(P) binding site [chemical binding]; other site 198215005167 substrate binding site [chemical binding]; other site 198215005168 dimer interface [polypeptide binding]; other site 198215005169 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215005170 HTH-like domain; Region: HTH_21; pfam13276 198215005171 Integrase core domain; Region: rve; pfam00665 198215005172 Integrase core domain; Region: rve_3; pfam13683 198215005173 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215005174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005175 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 198215005176 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198215005177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 198215005178 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 198215005179 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 198215005180 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 198215005181 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 198215005182 tetrameric interface [polypeptide binding]; other site 198215005183 NAD binding site [chemical binding]; other site 198215005184 catalytic residues [active] 198215005185 substrate binding site [chemical binding]; other site 198215005186 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198215005187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215005188 ABC-ATPase subunit interface; other site 198215005189 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215005190 Putative transposase; Region: Y2_Tnp; pfam04986 198215005191 Putative transposase; Region: Y2_Tnp; pfam04986 198215005192 Integrase core domain; Region: rve_3; cl15866 198215005193 Integrase core domain; Region: rve; pfam00665 198215005194 Transposase; Region: HTH_Tnp_1; cl17663 198215005195 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 198215005196 hypothetical protein; Provisional; Region: PRK10301 198215005197 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 198215005198 Predicted amidohydrolase [General function prediction only]; Region: COG0388 198215005199 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 198215005200 exodeoxyribonuclease X; Provisional; Region: PRK07983 198215005201 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 198215005202 active site 198215005203 catalytic site [active] 198215005204 substrate binding site [chemical binding]; other site 198215005205 protease 2; Provisional; Region: PRK10115 198215005206 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198215005207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 198215005208 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 198215005209 putative metal binding site [ion binding]; other site 198215005210 hypothetical protein; Provisional; Region: PRK13680 198215005211 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 198215005212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198215005213 ATP-grasp domain; Region: ATP-grasp; pfam02222 198215005214 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 198215005215 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 198215005216 active site 198215005217 intersubunit interface [polypeptide binding]; other site 198215005218 catalytic residue [active] 198215005219 phosphogluconate dehydratase; Validated; Region: PRK09054 198215005220 6-phosphogluconate dehydratase; Region: edd; TIGR01196 198215005221 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 198215005222 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 198215005223 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 198215005224 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 198215005225 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198215005226 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198215005227 putative active site [active] 198215005228 pyruvate kinase; Provisional; Region: PRK05826 198215005229 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 198215005230 domain interfaces; other site 198215005231 active site 198215005232 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 198215005233 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198215005234 putative acyl-acceptor binding pocket; other site 198215005235 putative peptidase; Provisional; Region: PRK11649 198215005236 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 198215005237 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215005238 Peptidase family M23; Region: Peptidase_M23; pfam01551 198215005239 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 198215005240 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 198215005241 metal binding site [ion binding]; metal-binding site 198215005242 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 198215005243 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198215005244 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 198215005245 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215005246 ABC-ATPase subunit interface; other site 198215005247 dimer interface [polypeptide binding]; other site 198215005248 putative PBP binding regions; other site 198215005249 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 198215005250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215005251 Walker A motif; other site 198215005252 ATP binding site [chemical binding]; other site 198215005253 Walker B motif; other site 198215005254 arginine finger; other site 198215005255 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 198215005256 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 198215005257 RuvA N terminal domain; Region: RuvA_N; pfam01330 198215005258 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 198215005259 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 198215005260 active site 198215005261 putative DNA-binding cleft [nucleotide binding]; other site 198215005262 dimer interface [polypeptide binding]; other site 198215005263 hypothetical protein; Validated; Region: PRK00110 198215005264 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 198215005265 nudix motif; other site 198215005266 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 198215005267 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 198215005268 dimer interface [polypeptide binding]; other site 198215005269 anticodon binding site; other site 198215005270 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 198215005271 homodimer interface [polypeptide binding]; other site 198215005272 motif 1; other site 198215005273 active site 198215005274 motif 2; other site 198215005275 GAD domain; Region: GAD; pfam02938 198215005276 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 198215005277 active site 198215005278 motif 3; other site 198215005279 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198215005280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198215005281 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198215005282 DinI-like family; Region: DinI; pfam06183 198215005283 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198215005284 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198215005285 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198215005286 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198215005287 Ash protein family; Region: Phage_ASH; pfam10554 198215005288 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 198215005289 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215005290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005291 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215005292 HTH-like domain; Region: HTH_21; pfam13276 198215005293 Integrase core domain; Region: rve; pfam00665 198215005294 Integrase core domain; Region: rve_3; pfam13683 198215005295 hypothetical protein; Reviewed; Region: PRK09790 198215005296 exonuclease VIII; Reviewed; Region: PRK09709 198215005297 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 198215005298 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 198215005299 AAA domain; Region: AAA_24; pfam13479 198215005300 Transposase; Region: HTH_Tnp_1; cl17663 198215005301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005302 Integrase core domain; Region: rve; pfam00665 198215005303 Integrase core domain; Region: rve_3; pfam13683 198215005304 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005306 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005307 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005308 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 198215005309 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 198215005310 Int/Topo IB signature motif; other site 198215005311 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 198215005312 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 198215005313 metal binding site [ion binding]; metal-binding site 198215005314 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 198215005315 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198215005316 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 198215005317 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215005318 ABC-ATPase subunit interface; other site 198215005319 dimer interface [polypeptide binding]; other site 198215005320 putative PBP binding regions; other site 198215005321 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 198215005322 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198215005323 ABC-ATPase subunit interface; other site 198215005324 dimer interface [polypeptide binding]; other site 198215005325 putative PBP binding regions; other site 198215005326 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198215005327 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 198215005328 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198215005329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215005330 Integrase core domain; Region: rve; pfam00665 198215005331 Integrase core domain; Region: rve_3; pfam13683 198215005332 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005334 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005335 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005336 Integrase core domain; Region: rve; pfam00665 198215005337 Integrase core domain; Region: rve_3; pfam13683 198215005338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005339 Transposase; Region: HTH_Tnp_1; pfam01527 198215005340 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 198215005341 Int/Topo IB signature motif; other site 198215005342 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 198215005343 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 198215005344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215005345 Integrase core domain; Region: rve; pfam00665 198215005346 Integrase core domain; Region: rve_3; pfam13683 198215005347 SPFH domain / Band 7 family; Region: Band_7; pfam01145 198215005348 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 198215005349 ORF6N domain; Region: ORF6N; pfam10543 198215005350 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 198215005351 beta-clamp/clamp loader binding surface; other site 198215005352 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 198215005353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005354 Transposase; Region: HTH_Tnp_1; pfam01527 198215005355 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 198215005356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215005357 S-adenosylmethionine binding site [chemical binding]; other site 198215005358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215005359 S-adenosylmethionine binding site [chemical binding]; other site 198215005360 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 198215005361 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 198215005362 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 198215005363 molybdopterin cofactor binding site [chemical binding]; other site 198215005364 substrate binding site [chemical binding]; other site 198215005365 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 198215005366 molybdopterin cofactor binding site; other site 198215005367 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 198215005368 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 198215005369 CutC family; Region: CutC; cl01218 198215005370 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 198215005371 putative metal binding site [ion binding]; other site 198215005372 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 198215005373 arginyl-tRNA synthetase; Region: argS; TIGR00456 198215005374 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 198215005375 active site 198215005376 HIGH motif; other site 198215005377 KMSK motif region; other site 198215005378 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 198215005379 tRNA binding surface [nucleotide binding]; other site 198215005380 anticodon binding site; other site 198215005381 Integrase core domain; Region: rve; pfam00665 198215005382 Integrase core domain; Region: rve_3; pfam13683 198215005383 Transposase; Region: HTH_Tnp_1; cl17663 198215005384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005385 Flagellar protein FlhE; Region: FlhE; pfam06366 198215005386 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 198215005387 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 198215005388 HD domain; Region: HD; pfam01966 198215005389 Zn2+ binding site [ion binding]; other site 198215005390 Mg2+ binding site [ion binding]; other site 198215005391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005392 Transposase; Region: HTH_Tnp_1; pfam01527 198215005393 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 198215005394 metal binding triad [ion binding]; metal-binding site 198215005395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215005396 Integrase core domain; Region: rve; pfam00665 198215005397 Integrase core domain; Region: rve_3; pfam13683 198215005398 chemotaxis regulator CheZ; Provisional; Region: PRK11166 198215005399 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 198215005400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215005401 active site 198215005402 phosphorylation site [posttranslational modification] 198215005403 intermolecular recognition site; other site 198215005404 dimerization interface [polypeptide binding]; other site 198215005405 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 198215005406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215005407 active site 198215005408 phosphorylation site [posttranslational modification] 198215005409 intermolecular recognition site; other site 198215005410 dimerization interface [polypeptide binding]; other site 198215005411 CheB methylesterase; Region: CheB_methylest; pfam01339 198215005412 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 198215005413 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 198215005414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215005415 S-adenosylmethionine binding site [chemical binding]; other site 198215005416 methyl-accepting protein IV; Provisional; Region: PRK09793 198215005417 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198215005418 dimer interface [polypeptide binding]; other site 198215005419 ligand binding site [chemical binding]; other site 198215005420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215005421 dimerization interface [polypeptide binding]; other site 198215005422 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198215005423 dimer interface [polypeptide binding]; other site 198215005424 putative CheW interface [polypeptide binding]; other site 198215005425 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 198215005426 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198215005427 dimer interface [polypeptide binding]; other site 198215005428 ligand binding site [chemical binding]; other site 198215005429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215005430 dimerization interface [polypeptide binding]; other site 198215005431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198215005432 dimer interface [polypeptide binding]; other site 198215005433 putative CheW interface [polypeptide binding]; other site 198215005434 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 198215005435 putative CheA interaction surface; other site 198215005436 chemotaxis protein CheA; Provisional; Region: PRK10547 198215005437 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198215005438 putative binding surface; other site 198215005439 active site 198215005440 CheY binding; Region: CheY-binding; pfam09078 198215005441 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 198215005442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215005443 ATP binding site [chemical binding]; other site 198215005444 Mg2+ binding site [ion binding]; other site 198215005445 G-X-G motif; other site 198215005446 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 198215005447 flagellar motor protein MotB; Validated; Region: motB; PRK09041 198215005448 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 198215005449 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198215005450 ligand binding site [chemical binding]; other site 198215005451 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 198215005452 flagellar motor protein MotA; Validated; Region: PRK09110 198215005453 transcriptional activator FlhC; Provisional; Region: PRK12722 198215005454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005455 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005456 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005457 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005458 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 198215005459 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 198215005460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215005461 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215005462 TM-ABC transporter signature motif; other site 198215005463 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 198215005464 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198215005465 Walker A/P-loop; other site 198215005466 ATP binding site [chemical binding]; other site 198215005467 Q-loop/lid; other site 198215005468 ABC transporter signature motif; other site 198215005469 Walker B; other site 198215005470 D-loop; other site 198215005471 H-loop/switch region; other site 198215005472 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198215005473 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 198215005474 Ferritin-like domain; Region: Ferritin; pfam00210 198215005475 ferroxidase diiron center [ion binding]; other site 198215005476 YecR-like lipoprotein; Region: YecR; pfam13992 198215005477 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 198215005478 Ferritin-like domain; Region: Ferritin; pfam00210 198215005479 ferroxidase diiron center [ion binding]; other site 198215005480 probable metal-binding protein; Region: matur_matur; TIGR03853 198215005481 tyrosine transporter TyrP; Provisional; Region: PRK15132 198215005482 aromatic amino acid transport protein; Region: araaP; TIGR00837 198215005483 hypothetical protein; Provisional; Region: PRK10396 198215005484 yecA family protein; Region: ygfB_yecA; TIGR02292 198215005485 SEC-C motif; Region: SEC-C; pfam02810 198215005486 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 198215005487 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 198215005488 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198215005489 GIY-YIG motif/motif A; other site 198215005490 active site 198215005491 catalytic site [active] 198215005492 putative DNA binding site [nucleotide binding]; other site 198215005493 metal binding site [ion binding]; metal-binding site 198215005494 UvrB/uvrC motif; Region: UVR; pfam02151 198215005495 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 198215005496 Helix-hairpin-helix motif; Region: HHH; pfam00633 198215005497 response regulator; Provisional; Region: PRK09483 198215005498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215005499 active site 198215005500 phosphorylation site [posttranslational modification] 198215005501 intermolecular recognition site; other site 198215005502 dimerization interface [polypeptide binding]; other site 198215005503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215005504 DNA binding residues [nucleotide binding] 198215005505 dimerization interface [polypeptide binding]; other site 198215005506 hypothetical protein; Provisional; Region: PRK10613 198215005507 Autoinducer binding domain; Region: Autoind_bind; pfam03472 198215005508 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215005509 DNA binding residues [nucleotide binding] 198215005510 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 198215005511 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198215005512 Walker A/P-loop; other site 198215005513 ATP binding site [chemical binding]; other site 198215005514 Q-loop/lid; other site 198215005515 ABC transporter signature motif; other site 198215005516 Walker B; other site 198215005517 D-loop; other site 198215005518 H-loop/switch region; other site 198215005519 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198215005520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215005521 dimer interface [polypeptide binding]; other site 198215005522 conserved gate region; other site 198215005523 putative PBP binding loops; other site 198215005524 ABC-ATPase subunit interface; other site 198215005525 D-cysteine desulfhydrase; Validated; Region: PRK03910 198215005526 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 198215005527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215005528 catalytic residue [active] 198215005529 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 198215005530 flagellin; Validated; Region: PRK08026 198215005531 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 198215005532 Flagellin protein; Region: FliC; pfam12445 198215005533 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 198215005534 flagellar capping protein; Reviewed; Region: fliD; PRK08032 198215005535 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 198215005536 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 198215005537 Flagellar protein FliS; Region: FliS; cl00654 198215005538 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 198215005539 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 198215005540 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 198215005541 active site 198215005542 Na/Ca binding site [ion binding]; other site 198215005543 catalytic site [active] 198215005544 lipoprotein; Provisional; Region: PRK10397 198215005545 putative inner membrane protein; Provisional; Region: PRK11099 198215005546 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 198215005547 CPxP motif; other site 198215005548 Probable transposase; Region: OrfB_IS605; pfam01385 198215005549 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 198215005550 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 198215005551 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198215005552 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198215005553 trimer interface [polypeptide binding]; other site 198215005554 eyelet of channel; other site 198215005555 transcriptional regulator HilD; Provisional; Region: PRK15185 198215005556 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 198215005557 substrate binding site [chemical binding]; other site 198215005558 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 198215005559 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 198215005560 flagellar motor switch protein FliG; Region: fliG; TIGR00207 198215005561 FliG C-terminal domain; Region: FliG_C; pfam01706 198215005562 flagellar assembly protein H; Validated; Region: fliH; PRK05687 198215005563 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 198215005564 Flagellar assembly protein FliH; Region: FliH; pfam02108 198215005565 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 198215005566 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 198215005567 Walker A motif/ATP binding site; other site 198215005568 Walker B motif; other site 198215005569 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 198215005570 flagellar hook-length control protein; Provisional; Region: PRK10118 198215005571 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 198215005572 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 198215005573 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 198215005574 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 198215005575 flagellar motor switch protein; Validated; Region: fliN; PRK05698 198215005576 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 198215005577 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 198215005578 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 198215005579 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 198215005580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215005581 DNA binding residues [nucleotide binding] 198215005582 dimerization interface [polypeptide binding]; other site 198215005583 hypothetical protein; Provisional; Region: PRK10708 198215005584 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 198215005585 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 198215005586 hypothetical protein; Provisional; Region: PRK10062 198215005587 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 198215005588 EamA-like transporter family; Region: EamA; pfam00892 198215005589 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 198215005590 additional DNA contacts [nucleotide binding]; other site 198215005591 mismatch recognition site; other site 198215005592 active site 198215005593 zinc binding site [ion binding]; other site 198215005594 DNA intercalation site [nucleotide binding]; other site 198215005595 DNA cytosine methylase; Provisional; Region: PRK10458 198215005596 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 198215005597 cofactor binding site; other site 198215005598 DNA binding site [nucleotide binding] 198215005599 substrate interaction site [chemical binding]; other site 198215005600 putative transposase OrfB; Reviewed; Region: PHA02517 198215005601 HTH-like domain; Region: HTH_21; pfam13276 198215005602 Integrase core domain; Region: rve; pfam00665 198215005603 Integrase core domain; Region: rve_2; pfam13333 198215005604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005605 Transposase; Region: HTH_Tnp_1; pfam01527 198215005606 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198215005607 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198215005608 eyelet of channel; other site 198215005609 trimer interface [polypeptide binding]; other site 198215005610 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215005611 HTH-like domain; Region: HTH_21; pfam13276 198215005612 Integrase core domain; Region: rve; pfam00665 198215005613 Integrase core domain; Region: rve_3; pfam13683 198215005614 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215005615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005616 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 198215005617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005618 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005619 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005620 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005621 chaperone protein HchA; Provisional; Region: PRK04155 198215005622 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 198215005623 dimer interface [polypeptide binding]; other site 198215005624 metal binding site [ion binding]; metal-binding site 198215005625 potential oxyanion hole; other site 198215005626 potential catalytic triad [active] 198215005627 conserved cys residue [active] 198215005628 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 198215005629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215005630 dimer interface [polypeptide binding]; other site 198215005631 phosphorylation site [posttranslational modification] 198215005632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215005633 ATP binding site [chemical binding]; other site 198215005634 Mg2+ binding site [ion binding]; other site 198215005635 G-X-G motif; other site 198215005636 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 198215005637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215005638 active site 198215005639 phosphorylation site [posttranslational modification] 198215005640 intermolecular recognition site; other site 198215005641 dimerization interface [polypeptide binding]; other site 198215005642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215005643 DNA binding site [nucleotide binding] 198215005644 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 198215005645 active site 198215005646 homotetramer interface [polypeptide binding]; other site 198215005647 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 198215005648 zinc/cadmium-binding protein; Provisional; Region: PRK10306 198215005649 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198215005650 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198215005651 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 198215005652 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198215005653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005654 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005655 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005656 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005657 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 198215005658 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 198215005659 Phage tail tube protein; Region: Tail_tube; pfam10618 198215005660 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 198215005661 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 198215005662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215005663 Integrase core domain; Region: rve; pfam00665 198215005664 Integrase core domain; Region: rve_3; pfam13683 198215005665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005666 Transposase; Region: HTH_Tnp_1; pfam01527 198215005667 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215005668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215005669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005670 Transposase; Region: HTH_Tnp_1; pfam01527 198215005671 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 198215005672 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 198215005673 Protein of unknown function (DUF968); Region: DUF968; pfam06147 198215005674 Hok/gef family; Region: HOK_GEF; pfam01848 198215005675 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 198215005676 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198215005677 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198215005678 active site 198215005679 DNA binding site [nucleotide binding] 198215005680 Int/Topo IB signature motif; other site 198215005681 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 198215005682 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198215005683 active site 198215005684 Int/Topo IB signature motif; other site 198215005685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005687 Transposase; Region: HTH_Tnp_1; pfam01527 198215005688 HTH-like domain; Region: HTH_21; pfam13276 198215005689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215005690 Integrase core domain; Region: rve; pfam00665 198215005691 Integrase core domain; Region: rve_3; pfam13683 198215005692 AMP nucleosidase; Provisional; Region: PRK08292 198215005693 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 198215005694 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 198215005695 hypothetical protein; Provisional; Region: PRK12378 198215005696 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 198215005697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215005698 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 198215005699 putative substrate binding site [chemical binding]; other site 198215005700 dimerization interface [polypeptide binding]; other site 198215005701 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 198215005702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215005703 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 198215005704 putative dimerization interface [polypeptide binding]; other site 198215005705 L,D-transpeptidase; Provisional; Region: PRK10190 198215005706 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198215005707 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 198215005708 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 198215005709 putative dimer interface [polypeptide binding]; other site 198215005710 active site pocket [active] 198215005711 putative cataytic base [active] 198215005712 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 198215005713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215005714 Integrase core domain; Region: rve; pfam00665 198215005715 Integrase core domain; Region: rve_3; pfam13683 198215005716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005717 Transposase; Region: HTH_Tnp_1; pfam01527 198215005718 Transposase; Region: HTH_Tnp_1; cl17663 198215005719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005720 Integrase core domain; Region: rve; pfam00665 198215005721 Integrase core domain; Region: rve_3; pfam13683 198215005722 hypothetical protein; Provisional; Region: PRK05423 198215005723 Homeodomain-like domain; Region: HTH_23; pfam13384 198215005724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005725 Transposase; Region: HTH_Tnp_1; pfam01527 198215005726 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215005727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215005728 Integrase core domain; Region: rve; pfam00665 198215005729 Integrase core domain; Region: rve_3; pfam13683 198215005730 putative transposase OrfB; Reviewed; Region: PHA02517 198215005731 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198215005732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215005733 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 198215005734 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215005735 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215005736 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198215005737 DNA binding site [nucleotide binding] 198215005738 active site 198215005739 Int/Topo IB signature motif; other site 198215005740 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215005741 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215005742 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198215005743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215005744 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 198215005745 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215005746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215005747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215005748 Transposase; Region: HTH_Tnp_1; pfam01527 198215005749 exonuclease I; Provisional; Region: sbcB; PRK11779 198215005750 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 198215005751 active site 198215005752 catalytic site [active] 198215005753 substrate binding site [chemical binding]; other site 198215005754 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 198215005755 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 198215005756 CPxP motif; other site 198215005757 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 198215005758 Sulphur transport; Region: Sulf_transp; pfam04143 198215005759 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198215005760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215005761 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 198215005762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215005763 dimerization interface [polypeptide binding]; other site 198215005764 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198215005765 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 198215005766 putative NAD(P) binding site [chemical binding]; other site 198215005767 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005769 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005770 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005771 antitoxin YefM; Provisional; Region: PRK11409 198215005772 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 198215005773 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 198215005774 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 198215005775 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 198215005776 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 198215005777 NAD binding site [chemical binding]; other site 198215005778 dimerization interface [polypeptide binding]; other site 198215005779 product binding site; other site 198215005780 substrate binding site [chemical binding]; other site 198215005781 zinc binding site [ion binding]; other site 198215005782 catalytic residues [active] 198215005783 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 198215005784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215005785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215005786 homodimer interface [polypeptide binding]; other site 198215005787 catalytic residue [active] 198215005788 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 198215005789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215005790 active site 198215005791 motif I; other site 198215005792 motif II; other site 198215005793 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 198215005794 putative active site pocket [active] 198215005795 4-fold oligomerization interface [polypeptide binding]; other site 198215005796 metal binding residues [ion binding]; metal-binding site 198215005797 3-fold/trimer interface [polypeptide binding]; other site 198215005798 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 198215005799 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 198215005800 putative active site [active] 198215005801 oxyanion strand; other site 198215005802 catalytic triad [active] 198215005803 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 198215005804 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 198215005805 catalytic residues [active] 198215005806 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 198215005807 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 198215005808 substrate binding site [chemical binding]; other site 198215005809 glutamase interaction surface [polypeptide binding]; other site 198215005810 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 198215005811 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 198215005812 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 198215005813 metal binding site [ion binding]; metal-binding site 198215005814 chain length determinant protein WzzB; Provisional; Region: PRK15471 198215005815 Chain length determinant protein; Region: Wzz; pfam02706 198215005816 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 198215005817 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 198215005818 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 198215005819 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 198215005820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198215005821 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 198215005822 Ligand binding site; other site 198215005823 Putative Catalytic site; other site 198215005824 DXD motif; other site 198215005825 Predicted membrane protein [Function unknown]; Region: COG2246 198215005826 GtrA-like protein; Region: GtrA; pfam04138 198215005827 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198215005828 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198215005829 active site 198215005830 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 198215005831 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 198215005832 Ligand binding site; other site 198215005833 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198215005834 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 198215005835 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 198215005836 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 198215005837 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 198215005838 substrate binding site; other site 198215005839 tetramer interface; other site 198215005840 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 198215005841 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 198215005842 NADP binding site [chemical binding]; other site 198215005843 active site 198215005844 putative substrate binding site [chemical binding]; other site 198215005845 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 198215005846 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 198215005847 NAD binding site [chemical binding]; other site 198215005848 substrate binding site [chemical binding]; other site 198215005849 homodimer interface [polypeptide binding]; other site 198215005850 active site 198215005851 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 198215005852 active site 198215005853 tetramer interface; other site 198215005854 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 198215005855 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 198215005856 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 198215005857 putative ADP-binding pocket [chemical binding]; other site 198215005858 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 198215005859 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 198215005860 colanic acid exporter; Provisional; Region: PRK10459 198215005861 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 198215005862 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 198215005863 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 198215005864 phosphomannomutase CpsG; Provisional; Region: PRK15414 198215005865 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 198215005866 active site 198215005867 substrate binding site [chemical binding]; other site 198215005868 metal binding site [ion binding]; metal-binding site 198215005869 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 198215005870 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 198215005871 Substrate binding site; other site 198215005872 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 198215005873 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 198215005874 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 198215005875 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 198215005876 active site 198215005877 GDP-Mannose binding site [chemical binding]; other site 198215005878 dimer interface [polypeptide binding]; other site 198215005879 modified nudix motif 198215005880 metal binding site [ion binding]; metal-binding site 198215005881 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 198215005882 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 198215005883 NADP binding site [chemical binding]; other site 198215005884 active site 198215005885 putative substrate binding site [chemical binding]; other site 198215005886 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 198215005887 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 198215005888 NADP-binding site; other site 198215005889 homotetramer interface [polypeptide binding]; other site 198215005890 substrate binding site [chemical binding]; other site 198215005891 homodimer interface [polypeptide binding]; other site 198215005892 active site 198215005893 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 198215005894 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 198215005895 putative trimer interface [polypeptide binding]; other site 198215005896 putative active site [active] 198215005897 putative substrate binding site [chemical binding]; other site 198215005898 putative CoA binding site [chemical binding]; other site 198215005899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005900 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005901 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005902 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005903 putative acyl transferase; Provisional; Region: PRK10191 198215005904 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 198215005905 trimer interface [polypeptide binding]; other site 198215005906 active site 198215005907 substrate binding site [chemical binding]; other site 198215005908 CoA binding site [chemical binding]; other site 198215005909 tyrosine kinase; Provisional; Region: PRK11519 198215005910 Chain length determinant protein; Region: Wzz; pfam02706 198215005911 Chain length determinant protein; Region: Wzz; cl15801 198215005912 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198215005913 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198215005914 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198215005915 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 198215005916 active site 198215005917 polysaccharide export protein Wza; Provisional; Region: PRK15078 198215005918 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 198215005919 SLBB domain; Region: SLBB; pfam10531 198215005920 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198215005921 FOG: CBS domain [General function prediction only]; Region: COG0517 198215005922 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198215005923 Transporter associated domain; Region: CorC_HlyC; smart01091 198215005924 putative assembly protein; Provisional; Region: PRK10833 198215005925 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198215005926 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 198215005927 trimer interface [polypeptide binding]; other site 198215005928 active site 198215005929 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 198215005930 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 198215005931 ATP-binding site [chemical binding]; other site 198215005932 Sugar specificity; other site 198215005933 Pyrimidine base specificity; other site 198215005934 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198215005935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198215005936 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198215005937 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 198215005938 AlkA N-terminal domain; Region: AlkA_N; smart01009 198215005939 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198215005940 minor groove reading motif; other site 198215005941 helix-hairpin-helix signature motif; other site 198215005942 substrate binding pocket [chemical binding]; other site 198215005943 active site 198215005944 Protein phosphatase 2C; Region: PP2C_2; pfam13672 198215005945 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 198215005946 metal ion-dependent adhesion site (MIDAS); other site 198215005947 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198215005948 Y-family of DNA polymerases; Region: PolY; cl12025 198215005949 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198215005950 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 198215005951 putative transporter; Provisional; Region: PRK10504 198215005952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215005953 putative substrate translocation pore; other site 198215005954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215005955 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 198215005956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215005957 dimerization interface [polypeptide binding]; other site 198215005958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215005959 dimer interface [polypeptide binding]; other site 198215005960 phosphorylation site [posttranslational modification] 198215005961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215005962 ATP binding site [chemical binding]; other site 198215005963 Mg2+ binding site [ion binding]; other site 198215005964 G-X-G motif; other site 198215005965 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 198215005966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215005967 active site 198215005968 phosphorylation site [posttranslational modification] 198215005969 intermolecular recognition site; other site 198215005970 dimerization interface [polypeptide binding]; other site 198215005971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215005972 DNA binding site [nucleotide binding] 198215005973 Uncharacterized conserved protein [Function unknown]; Region: COG3422 198215005974 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 198215005975 putative protease; Provisional; Region: PRK15452 198215005976 Peptidase family U32; Region: Peptidase_U32; pfam01136 198215005977 lipid kinase; Reviewed; Region: PRK13054 198215005978 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 198215005979 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198215005980 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198215005981 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215005982 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 198215005983 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 198215005984 putative NAD(P) binding site [chemical binding]; other site 198215005985 catalytic Zn binding site [ion binding]; other site 198215005986 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215005987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215005988 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215005989 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215005990 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 198215005991 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 198215005992 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 198215005993 active site 198215005994 P-loop; other site 198215005995 phosphorylation site [posttranslational modification] 198215005996 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215005997 active site 198215005998 phosphorylation site [posttranslational modification] 198215005999 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 198215006000 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 198215006001 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 198215006002 intersubunit interface [polypeptide binding]; other site 198215006003 active site 198215006004 zinc binding site [ion binding]; other site 198215006005 Na+ binding site [ion binding]; other site 198215006006 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 198215006007 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 198215006008 putative active site; other site 198215006009 catalytic residue [active] 198215006010 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215006011 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 198215006012 substrate binding site [chemical binding]; other site 198215006013 ATP binding site [chemical binding]; other site 198215006014 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198215006015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215006016 DNA-binding site [nucleotide binding]; DNA binding site 198215006017 UTRA domain; Region: UTRA; pfam07702 198215006018 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 198215006019 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 198215006020 active site 198215006021 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 198215006022 dimer interface [polypeptide binding]; other site 198215006023 substrate binding site [chemical binding]; other site 198215006024 ATP binding site [chemical binding]; other site 198215006025 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 198215006026 substrate binding site [chemical binding]; other site 198215006027 multimerization interface [polypeptide binding]; other site 198215006028 ATP binding site [chemical binding]; other site 198215006029 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 198215006030 putative metal binding site [ion binding]; other site 198215006031 putative homodimer interface [polypeptide binding]; other site 198215006032 putative homotetramer interface [polypeptide binding]; other site 198215006033 putative homodimer-homodimer interface [polypeptide binding]; other site 198215006034 putative allosteric switch controlling residues; other site 198215006035 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 198215006036 PapC N-terminal domain; Region: PapC_N; pfam13954 198215006037 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 198215006038 PapC C-terminal domain; Region: PapC_C; pfam13953 198215006039 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198215006040 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215006041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215006042 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215006043 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215006044 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 198215006045 antiporter inner membrane protein; Provisional; Region: PRK11670 198215006046 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 198215006047 Walker A motif; other site 198215006048 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 198215006049 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 198215006050 active site 198215006051 HIGH motif; other site 198215006052 KMSKS motif; other site 198215006053 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 198215006054 tRNA binding surface [nucleotide binding]; other site 198215006055 anticodon binding site; other site 198215006056 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 198215006057 dimer interface [polypeptide binding]; other site 198215006058 putative tRNA-binding site [nucleotide binding]; other site 198215006059 residues 1 to 100 of 100 are 100.00 pct identical to residues 1 to 100 of 100 from GenPept : >gb|AAF09029.1| (AF139596) unknown [Shigella flexneri]; IS600 orfA 198215006060 residues 1 to 237 of 237 are 90.71 pct identical to residues 36 to 272 of 272 from GenPept : >gb|AAK18576.1|AF348706_265 (AF348706) IS600 orfB [Shigella flexneri]; IS600 orfB 198215006061 residues 1 to 91 of 91 are 100.00 pct identical to residues 1 to 91 of 91 from GenPept : >gb|AAK18550.1|AF348706_239 (AF348706) iso-IS1 orfA [Shigella flexneri]; IS1 orfA 198215006062 residues 1 to 97 of 97 are 82.47 pct identical to residues 35 to 131 of 131 from GenPept : >gb|AAL72404.1| (AF386526) transposase [Shigella flexneri 2a]; partial; IS1 orfB 198215006063 MoxR-like ATPases [General function prediction only]; Region: COG0714 198215006064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215006065 Walker A motif; other site 198215006066 ATP binding site [chemical binding]; other site 198215006067 Walker B motif; other site 198215006068 arginine finger; other site 198215006069 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 198215006070 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 198215006071 metal ion-dependent adhesion site (MIDAS); other site 198215006072 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215006073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215006074 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215006075 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215006076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 198215006077 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215006078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215006079 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215006080 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215006081 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 198215006082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215006083 active site 198215006084 phosphorylation site [posttranslational modification] 198215006085 intermolecular recognition site; other site 198215006086 dimerization interface [polypeptide binding]; other site 198215006087 LytTr DNA-binding domain; Region: LytTR; pfam04397 198215006088 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 198215006089 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198215006090 GAF domain; Region: GAF; pfam01590 198215006091 Histidine kinase; Region: His_kinase; pfam06580 198215006092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215006093 ATP binding site [chemical binding]; other site 198215006094 Mg2+ binding site [ion binding]; other site 198215006095 G-X-G motif; other site 198215006096 DinI-like family; Region: DinI; pfam06183 198215006097 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198215006098 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198215006099 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 198215006100 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198215006101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215006102 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215006103 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215006104 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215006105 Transposase; Region: HTH_Tnp_1; cl17663 198215006106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215006107 Integrase core domain; Region: rve; pfam00665 198215006108 Integrase core domain; Region: rve_3; pfam13683 198215006109 hypothetical protein; Provisional; Region: PRK13681 198215006110 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198215006111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215006112 dimer interface [polypeptide binding]; other site 198215006113 conserved gate region; other site 198215006114 putative PBP binding loops; other site 198215006115 ABC-ATPase subunit interface; other site 198215006116 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 198215006117 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 198215006118 Walker A/P-loop; other site 198215006119 ATP binding site [chemical binding]; other site 198215006120 Q-loop/lid; other site 198215006121 ABC transporter signature motif; other site 198215006122 Walker B; other site 198215006123 D-loop; other site 198215006124 H-loop/switch region; other site 198215006125 CBS domain; Region: CBS; pfam00571 198215006126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215006127 dimer interface [polypeptide binding]; other site 198215006128 conserved gate region; other site 198215006129 ABC-ATPase subunit interface; other site 198215006130 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 198215006131 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 198215006132 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 198215006133 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 198215006134 D-lactate dehydrogenase; Provisional; Region: PRK11183 198215006135 FAD binding domain; Region: FAD_binding_4; pfam01565 198215006136 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 198215006137 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 198215006138 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 198215006139 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 198215006140 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198215006141 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 198215006142 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 198215006143 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198215006144 FMN binding site [chemical binding]; other site 198215006145 active site 198215006146 catalytic residues [active] 198215006147 substrate binding site [chemical binding]; other site 198215006148 hypothetical protein; Provisional; Region: PRK01821 198215006149 hypothetical protein; Provisional; Region: PRK10711 198215006150 cytidine deaminase; Provisional; Region: PRK09027 198215006151 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198215006152 active site 198215006153 catalytic motif [active] 198215006154 Zn binding site [ion binding]; other site 198215006155 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198215006156 active site 198215006157 catalytic motif [active] 198215006158 Zn binding site [ion binding]; other site 198215006159 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198215006160 putative active site [active] 198215006161 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 198215006162 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 198215006163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198215006164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215006165 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215006166 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215006167 TM-ABC transporter signature motif; other site 198215006168 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198215006169 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 198215006170 Walker A/P-loop; other site 198215006171 ATP binding site [chemical binding]; other site 198215006172 Q-loop/lid; other site 198215006173 ABC transporter signature motif; other site 198215006174 Walker B; other site 198215006175 D-loop; other site 198215006176 H-loop/switch region; other site 198215006177 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198215006178 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 198215006179 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 198215006180 ligand binding site [chemical binding]; other site 198215006181 calcium binding site [ion binding]; other site 198215006182 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 198215006183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215006184 DNA binding site [nucleotide binding] 198215006185 domain linker motif; other site 198215006186 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198215006187 dimerization interface (closed form) [polypeptide binding]; other site 198215006188 ligand binding site [chemical binding]; other site 198215006189 Predicted membrane protein [Function unknown]; Region: COG2311 198215006190 hypothetical protein; Provisional; Region: PRK10835 198215006191 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 198215006192 homodecamer interface [polypeptide binding]; other site 198215006193 GTP cyclohydrolase I; Provisional; Region: PLN03044 198215006194 active site 198215006195 putative catalytic site residues [active] 198215006196 zinc binding site [ion binding]; other site 198215006197 GTP-CH-I/GFRP interaction surface; other site 198215006198 lysine transporter; Provisional; Region: PRK10836 198215006199 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 198215006200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215006201 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 198215006202 putative dimerization interface [polypeptide binding]; other site 198215006203 conserved hypothetical integral membrane protein; Region: TIGR00698 198215006204 endonuclease IV; Provisional; Region: PRK01060 198215006205 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 198215006206 AP (apurinic/apyrimidinic) site pocket; other site 198215006207 DNA interaction; other site 198215006208 Metal-binding active site; metal-binding site 198215006209 putative kinase; Provisional; Region: PRK09954 198215006210 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 198215006211 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 198215006212 substrate binding site [chemical binding]; other site 198215006213 ATP binding site [chemical binding]; other site 198215006214 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198215006215 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198215006216 Nucleoside recognition; Region: Gate; pfam07670 198215006217 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198215006218 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198215006219 active site 198215006220 tetramer interface [polypeptide binding]; other site 198215006221 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 198215006222 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198215006223 ligand binding site [chemical binding]; other site 198215006224 flexible hinge region; other site 198215006225 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198215006226 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198215006227 Nucleoside recognition; Region: Gate; pfam07670 198215006228 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198215006229 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 198215006230 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 198215006231 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215006232 substrate binding site [chemical binding]; other site 198215006233 ATP binding site [chemical binding]; other site 198215006234 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 198215006235 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 198215006236 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198215006237 active site 198215006238 P-loop; other site 198215006239 phosphorylation site [posttranslational modification] 198215006240 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 198215006241 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 198215006242 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 198215006243 putative substrate binding site [chemical binding]; other site 198215006244 putative ATP binding site [chemical binding]; other site 198215006245 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 198215006246 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215006247 active site 198215006248 phosphorylation site [posttranslational modification] 198215006249 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198215006250 dimerization domain swap beta strand [polypeptide binding]; other site 198215006251 regulatory protein interface [polypeptide binding]; other site 198215006252 active site 198215006253 regulatory phosphorylation site [posttranslational modification]; other site 198215006254 sugar efflux transporter B; Provisional; Region: PRK15011 198215006255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215006256 putative substrate translocation pore; other site 198215006257 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215006258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215006259 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215006260 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215006261 elongation factor P; Provisional; Region: PRK04542 198215006262 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 198215006263 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 198215006264 RNA binding site [nucleotide binding]; other site 198215006265 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 198215006266 RNA binding site [nucleotide binding]; other site 198215006267 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 198215006268 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198215006269 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198215006270 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 198215006271 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 198215006272 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 198215006273 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198215006274 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 198215006275 active site 198215006276 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 198215006277 NlpC/P60 family; Region: NLPC_P60; pfam00877 198215006278 phage resistance protein; Provisional; Region: PRK10551 198215006279 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198215006280 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198215006281 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198215006282 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 198215006283 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 198215006284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215006285 dimer interface [polypeptide binding]; other site 198215006286 conserved gate region; other site 198215006287 putative PBP binding loops; other site 198215006288 ABC-ATPase subunit interface; other site 198215006289 microcin C ABC transporter permease; Provisional; Region: PRK15021 198215006290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215006291 dimer interface [polypeptide binding]; other site 198215006292 conserved gate region; other site 198215006293 ABC-ATPase subunit interface; other site 198215006294 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 198215006295 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215006296 Walker A/P-loop; other site 198215006297 ATP binding site [chemical binding]; other site 198215006298 Q-loop/lid; other site 198215006299 ABC transporter signature motif; other site 198215006300 Walker B; other site 198215006301 D-loop; other site 198215006302 H-loop/switch region; other site 198215006303 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198215006304 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215006305 Walker A/P-loop; other site 198215006306 ATP binding site [chemical binding]; other site 198215006307 Q-loop/lid; other site 198215006308 ABC transporter signature motif; other site 198215006309 Walker B; other site 198215006310 D-loop; other site 198215006311 H-loop/switch region; other site 198215006312 hypothetical protein; Provisional; Region: PRK11835 198215006313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215006314 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 198215006315 putative substrate translocation pore; other site 198215006316 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 198215006317 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215006318 RNA binding surface [nucleotide binding]; other site 198215006319 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 198215006320 active site 198215006321 uracil binding [chemical binding]; other site 198215006322 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 198215006323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215006324 ATP binding site [chemical binding]; other site 198215006325 putative Mg++ binding site [ion binding]; other site 198215006326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215006327 nucleotide binding region [chemical binding]; other site 198215006328 ATP-binding site [chemical binding]; other site 198215006329 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 198215006330 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 198215006331 5S rRNA interface [nucleotide binding]; other site 198215006332 CTC domain interface [polypeptide binding]; other site 198215006333 L16 interface [polypeptide binding]; other site 198215006334 Nucleoid-associated protein [General function prediction only]; Region: COG3081 198215006335 nucleoid-associated protein NdpA; Validated; Region: PRK00378 198215006336 hypothetical protein; Provisional; Region: PRK13689 198215006337 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 198215006338 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 198215006339 Sulfatase; Region: Sulfatase; pfam00884 198215006340 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 198215006341 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198215006342 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198215006343 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198215006344 transcriptional regulator NarP; Provisional; Region: PRK10403 198215006345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215006346 active site 198215006347 phosphorylation site [posttranslational modification] 198215006348 intermolecular recognition site; other site 198215006349 dimerization interface [polypeptide binding]; other site 198215006350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215006351 DNA binding residues [nucleotide binding] 198215006352 dimerization interface [polypeptide binding]; other site 198215006353 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 198215006354 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 198215006355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198215006356 binding surface 198215006357 TPR motif; other site 198215006358 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 198215006359 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 198215006360 catalytic residues [active] 198215006361 central insert; other site 198215006362 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 198215006363 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 198215006364 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 198215006365 heme exporter protein CcmC; Region: ccmC; TIGR01191 198215006366 heme exporter protein CcmB; Region: ccmB; TIGR01190 198215006367 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 198215006368 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 198215006369 Walker A/P-loop; other site 198215006370 ATP binding site [chemical binding]; other site 198215006371 Q-loop/lid; other site 198215006372 ABC transporter signature motif; other site 198215006373 Walker B; other site 198215006374 D-loop; other site 198215006375 H-loop/switch region; other site 198215006376 cytochrome c-type protein NapC; Provisional; Region: PRK10617 198215006377 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 198215006378 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 198215006379 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 198215006380 4Fe-4S binding domain; Region: Fer4_5; pfam12801 198215006381 4Fe-4S binding domain; Region: Fer4; cl02805 198215006382 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 198215006383 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 198215006384 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 198215006385 [4Fe-4S] binding site [ion binding]; other site 198215006386 molybdopterin cofactor binding site; other site 198215006387 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 198215006388 molybdopterin cofactor binding site; other site 198215006389 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 198215006390 ferredoxin-type protein; Provisional; Region: PRK10194 198215006391 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 198215006392 secondary substrate binding site; other site 198215006393 primary substrate binding site; other site 198215006394 inhibition loop; other site 198215006395 dimerization interface [polypeptide binding]; other site 198215006396 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 198215006397 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 198215006398 Walker A/P-loop; other site 198215006399 ATP binding site [chemical binding]; other site 198215006400 Q-loop/lid; other site 198215006401 ABC transporter signature motif; other site 198215006402 Walker B; other site 198215006403 D-loop; other site 198215006404 H-loop/switch region; other site 198215006405 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 198215006406 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 198215006407 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 198215006408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215006409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215006410 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 198215006411 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198215006412 DNA binding site [nucleotide binding] 198215006413 active site 198215006414 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 198215006415 ApbE family; Region: ApbE; pfam02424 198215006416 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198215006417 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198215006418 trimer interface [polypeptide binding]; other site 198215006419 eyelet of channel; other site 198215006420 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 198215006421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215006422 ATP binding site [chemical binding]; other site 198215006423 G-X-G motif; other site 198215006424 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198215006425 putative binding surface; other site 198215006426 active site 198215006427 transcriptional regulator RcsB; Provisional; Region: PRK10840 198215006428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215006429 active site 198215006430 phosphorylation site [posttranslational modification] 198215006431 intermolecular recognition site; other site 198215006432 dimerization interface [polypeptide binding]; other site 198215006433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215006434 DNA binding residues [nucleotide binding] 198215006435 dimerization interface [polypeptide binding]; other site 198215006436 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 198215006437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215006438 dimer interface [polypeptide binding]; other site 198215006439 phosphorylation site [posttranslational modification] 198215006440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215006441 ATP binding site [chemical binding]; other site 198215006442 Mg2+ binding site [ion binding]; other site 198215006443 G-X-G motif; other site 198215006444 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 198215006445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215006446 active site 198215006447 phosphorylation site [posttranslational modification] 198215006448 intermolecular recognition site; other site 198215006449 dimerization interface [polypeptide binding]; other site 198215006450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 198215006451 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 198215006452 Predicted secreted protein [Function unknown]; Region: COG5445 198215006453 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 198215006454 Predicted secreted protein [Function unknown]; Region: COG5445 198215006455 Stage II sporulation protein; Region: SpoIID; pfam08486 198215006456 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 198215006457 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 198215006458 Integrase core domain; Region: rve; pfam00665 198215006459 Integrase core domain; Region: rve_3; pfam13683 198215006460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215006461 Transposase; Region: HTH_Tnp_1; pfam01527 198215006462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 198215006463 DNA gyrase subunit A; Validated; Region: PRK05560 198215006464 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198215006465 CAP-like domain; other site 198215006466 active site 198215006467 primary dimer interface [polypeptide binding]; other site 198215006468 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198215006469 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198215006470 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198215006471 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198215006472 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198215006473 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198215006474 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 198215006475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215006476 S-adenosylmethionine binding site [chemical binding]; other site 198215006477 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215006478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215006479 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215006480 HTH-like domain; Region: HTH_21; pfam13276 198215006481 Integrase core domain; Region: rve; pfam00665 198215006482 Integrase core domain; Region: rve_3; pfam13683 198215006483 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 198215006484 ATP cone domain; Region: ATP-cone; pfam03477 198215006485 Class I ribonucleotide reductase; Region: RNR_I; cd01679 198215006486 active site 198215006487 dimer interface [polypeptide binding]; other site 198215006488 catalytic residues [active] 198215006489 effector binding site; other site 198215006490 R2 peptide binding site; other site 198215006491 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 198215006492 dimer interface [polypeptide binding]; other site 198215006493 putative radical transfer pathway; other site 198215006494 diiron center [ion binding]; other site 198215006495 tyrosyl radical; other site 198215006496 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 198215006497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198215006498 catalytic loop [active] 198215006499 iron binding site [ion binding]; other site 198215006500 hypothetical protein; Provisional; Region: PRK09902 198215006501 hypothetical protein; Provisional; Region: PRK09729 198215006502 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 198215006503 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 198215006504 active site 198215006505 catalytic site [active] 198215006506 metal binding site [ion binding]; metal-binding site 198215006507 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 198215006508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215006509 putative substrate translocation pore; other site 198215006510 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 198215006511 hydroxyglutarate oxidase; Provisional; Region: PRK11728 198215006512 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198215006513 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 198215006514 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 198215006515 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 198215006516 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198215006517 Cysteine-rich domain; Region: CCG; pfam02754 198215006518 Cysteine-rich domain; Region: CCG; pfam02754 198215006519 hypothetical protein; Provisional; Region: PRK09956 198215006520 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198215006521 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198215006522 hypothetical protein; Provisional; Region: PRK03673 198215006523 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 198215006524 putative MPT binding site; other site 198215006525 Competence-damaged protein; Region: CinA; cl00666 198215006526 YfaZ precursor; Region: YfaZ; pfam07437 198215006527 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 198215006528 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 198215006529 catalytic core [active] 198215006530 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 198215006531 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 198215006532 inhibitor-cofactor binding pocket; inhibition site 198215006533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215006534 catalytic residue [active] 198215006535 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 198215006536 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 198215006537 Ligand binding site; other site 198215006538 Putative Catalytic site; other site 198215006539 DXD motif; other site 198215006540 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 198215006541 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 198215006542 active site 198215006543 hexamer interface [polypeptide binding]; other site 198215006544 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 198215006545 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 198215006546 NAD binding site [chemical binding]; other site 198215006547 substrate binding site [chemical binding]; other site 198215006548 active site 198215006549 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 198215006550 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 198215006551 putative active site [active] 198215006552 putative catalytic site [active] 198215006553 putative Zn binding site [ion binding]; other site 198215006554 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 198215006555 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 198215006556 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 198215006557 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 198215006558 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 198215006559 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 198215006560 acyl-activating enzyme (AAE) consensus motif; other site 198215006561 putative AMP binding site [chemical binding]; other site 198215006562 putative active site [active] 198215006563 putative CoA binding site [chemical binding]; other site 198215006564 O-succinylbenzoate synthase; Provisional; Region: PRK05105 198215006565 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 198215006566 active site 198215006567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198215006568 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 198215006569 substrate binding site [chemical binding]; other site 198215006570 oxyanion hole (OAH) forming residues; other site 198215006571 trimer interface [polypeptide binding]; other site 198215006572 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 198215006573 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 198215006574 catalytic site [active] 198215006575 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 198215006576 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 198215006577 dimer interface [polypeptide binding]; other site 198215006578 tetramer interface [polypeptide binding]; other site 198215006579 PYR/PP interface [polypeptide binding]; other site 198215006580 TPP binding site [chemical binding]; other site 198215006581 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 198215006582 TPP-binding site; other site 198215006583 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 198215006584 isochorismate synthases; Region: isochor_syn; TIGR00543 198215006585 hypothetical protein; Provisional; Region: PRK10404 198215006586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215006587 Coenzyme A binding pocket [chemical binding]; other site 198215006588 ribonuclease BN; Region: true_RNase_BN; TIGR02649 198215006589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215006590 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215006591 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215006592 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215006593 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 198215006594 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198215006595 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 198215006596 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198215006597 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 198215006598 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 198215006599 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198215006600 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 198215006601 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 198215006602 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 198215006603 4Fe-4S binding domain; Region: Fer4; pfam00037 198215006604 4Fe-4S binding domain; Region: Fer4; pfam00037 198215006605 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 198215006606 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 198215006607 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198215006608 catalytic loop [active] 198215006609 iron binding site [ion binding]; other site 198215006610 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 198215006611 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 198215006612 [4Fe-4S] binding site [ion binding]; other site 198215006613 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 198215006614 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 198215006615 SLBB domain; Region: SLBB; pfam10531 198215006616 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 198215006617 NADH dehydrogenase subunit E; Validated; Region: PRK07539 198215006618 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 198215006619 putative dimer interface [polypeptide binding]; other site 198215006620 [2Fe-2S] cluster binding site [ion binding]; other site 198215006621 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 198215006622 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 198215006623 NADH dehydrogenase subunit D; Validated; Region: PRK06075 198215006624 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 198215006625 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 198215006626 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 198215006627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215006628 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 198215006629 putative dimerization interface [polypeptide binding]; other site 198215006630 aminotransferase AlaT; Validated; Region: PRK09265 198215006631 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215006632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215006633 homodimer interface [polypeptide binding]; other site 198215006634 catalytic residue [active] 198215006635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198215006636 Zn2+ binding site [ion binding]; other site 198215006637 Mg2+ binding site [ion binding]; other site 198215006638 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 198215006639 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198215006640 TrkA-C domain; Region: TrkA_C; pfam02080 198215006641 TrkA-C domain; Region: TrkA_C; pfam02080 198215006642 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 198215006643 putative phosphatase; Provisional; Region: PRK11587 198215006644 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198215006645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215006646 motif II; other site 198215006647 hypothetical protein; Validated; Region: PRK05445 198215006648 hypothetical protein; Provisional; Region: PRK01816 198215006649 propionate/acetate kinase; Provisional; Region: PRK12379 198215006650 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 198215006651 phosphate acetyltransferase; Reviewed; Region: PRK05632 198215006652 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198215006653 DRTGG domain; Region: DRTGG; pfam07085 198215006654 phosphate acetyltransferase; Region: pta; TIGR00651 198215006655 hypothetical protein; Provisional; Region: PRK11588 198215006656 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 198215006657 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 198215006658 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 198215006659 nudix motif; other site 198215006660 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 198215006661 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198215006662 active site 198215006663 metal binding site [ion binding]; metal-binding site 198215006664 homotetramer interface [polypeptide binding]; other site 198215006665 glutathione S-transferase; Provisional; Region: PRK15113 198215006666 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 198215006667 C-terminal domain interface [polypeptide binding]; other site 198215006668 GSH binding site (G-site) [chemical binding]; other site 198215006669 dimer interface [polypeptide binding]; other site 198215006670 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 198215006671 N-terminal domain interface [polypeptide binding]; other site 198215006672 putative dimer interface [polypeptide binding]; other site 198215006673 putative substrate binding pocket (H-site) [chemical binding]; other site 198215006674 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 198215006675 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 198215006676 C-terminal domain interface [polypeptide binding]; other site 198215006677 GSH binding site (G-site) [chemical binding]; other site 198215006678 dimer interface [polypeptide binding]; other site 198215006679 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 198215006680 N-terminal domain interface [polypeptide binding]; other site 198215006681 putative dimer interface [polypeptide binding]; other site 198215006682 active site 198215006683 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 198215006684 homooctamer interface [polypeptide binding]; other site 198215006685 active site 198215006686 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 198215006687 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 198215006688 putative NAD(P) binding site [chemical binding]; other site 198215006689 putative active site [active] 198215006690 putative transposase; Provisional; Region: PRK09857 198215006691 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198215006692 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 198215006693 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198215006694 Walker A/P-loop; other site 198215006695 ATP binding site [chemical binding]; other site 198215006696 Q-loop/lid; other site 198215006697 ABC transporter signature motif; other site 198215006698 Walker B; other site 198215006699 D-loop; other site 198215006700 H-loop/switch region; other site 198215006701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215006702 dimer interface [polypeptide binding]; other site 198215006703 conserved gate region; other site 198215006704 putative PBP binding loops; other site 198215006705 ABC-ATPase subunit interface; other site 198215006706 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198215006707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215006708 dimer interface [polypeptide binding]; other site 198215006709 conserved gate region; other site 198215006710 putative PBP binding loops; other site 198215006711 ABC-ATPase subunit interface; other site 198215006712 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 198215006713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215006714 substrate binding pocket [chemical binding]; other site 198215006715 membrane-bound complex binding site; other site 198215006716 hinge residues; other site 198215006717 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 198215006718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215006719 substrate binding pocket [chemical binding]; other site 198215006720 membrane-bound complex binding site; other site 198215006721 hinge residues; other site 198215006722 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 198215006723 Flavoprotein; Region: Flavoprotein; pfam02441 198215006724 amidophosphoribosyltransferase; Provisional; Region: PRK09246 198215006725 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 198215006726 active site 198215006727 tetramer interface [polypeptide binding]; other site 198215006728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215006729 active site 198215006730 colicin V production protein; Provisional; Region: PRK10845 198215006731 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 198215006732 cell division protein DedD; Provisional; Region: PRK11633 198215006733 Sporulation related domain; Region: SPOR; pfam05036 198215006734 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 198215006735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198215006736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198215006737 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 198215006738 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 198215006739 hypothetical protein; Provisional; Region: PRK10847 198215006740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198215006741 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 198215006742 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 198215006743 dimerization interface 3.5A [polypeptide binding]; other site 198215006744 active site 198215006745 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 198215006746 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 198215006747 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 198215006748 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 198215006749 ligand binding site [chemical binding]; other site 198215006750 NAD binding site [chemical binding]; other site 198215006751 catalytic site [active] 198215006752 homodimer interface [polypeptide binding]; other site 198215006753 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 198215006754 putative transporter; Provisional; Region: PRK12382 198215006755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215006756 putative substrate translocation pore; other site 198215006757 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 198215006758 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198215006759 dimer interface [polypeptide binding]; other site 198215006760 active site 198215006761 Uncharacterized conserved protein [Function unknown]; Region: COG4121 198215006762 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 198215006763 YfcL protein; Region: YfcL; pfam08891 198215006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 198215006765 hypothetical protein; Provisional; Region: PRK10621 198215006766 Predicted permeases [General function prediction only]; Region: COG0730 198215006767 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 198215006768 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 198215006769 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 198215006770 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 198215006771 Tetramer interface [polypeptide binding]; other site 198215006772 active site 198215006773 FMN-binding site [chemical binding]; other site 198215006774 HemK family putative methylases; Region: hemK_fam; TIGR00536 198215006775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215006776 S-adenosylmethionine binding site [chemical binding]; other site 198215006777 hypothetical protein; Provisional; Region: PRK04946 198215006778 Smr domain; Region: Smr; pfam01713 198215006779 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198215006780 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215006781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215006782 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215006783 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215006784 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198215006785 catalytic core [active] 198215006786 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 198215006787 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198215006788 substrate binding site [chemical binding]; other site 198215006789 oxyanion hole (OAH) forming residues; other site 198215006790 trimer interface [polypeptide binding]; other site 198215006791 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198215006792 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198215006793 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 198215006794 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198215006795 dimer interface [polypeptide binding]; other site 198215006796 active site 198215006797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 198215006798 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 198215006799 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 198215006800 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 198215006801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215006802 Transposase; Region: HTH_Tnp_1; pfam01527 198215006803 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215006804 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215006805 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 198215006806 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 198215006807 substrate binding [chemical binding]; other site 198215006808 active site 198215006809 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 198215006810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215006811 DNA binding site [nucleotide binding] 198215006812 domain linker motif; other site 198215006813 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 198215006814 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 198215006815 putative dimerization interface [polypeptide binding]; other site 198215006816 putative ligand binding site [chemical binding]; other site 198215006817 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 198215006818 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 198215006819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198215006820 catalytic residue [active] 198215006821 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198215006822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215006823 putative substrate translocation pore; other site 198215006824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215006825 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 198215006826 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215006827 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 198215006828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215006829 active site 198215006830 phosphorylation site [posttranslational modification] 198215006831 intermolecular recognition site; other site 198215006832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215006833 DNA binding residues [nucleotide binding] 198215006834 dimerization interface [polypeptide binding]; other site 198215006835 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 198215006836 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215006837 substrate binding pocket [chemical binding]; other site 198215006838 membrane-bound complex binding site; other site 198215006839 hinge residues; other site 198215006840 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215006841 substrate binding pocket [chemical binding]; other site 198215006842 membrane-bound complex binding site; other site 198215006843 hinge residues; other site 198215006844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215006845 dimer interface [polypeptide binding]; other site 198215006846 phosphorylation site [posttranslational modification] 198215006847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215006848 ATP binding site [chemical binding]; other site 198215006849 Mg2+ binding site [ion binding]; other site 198215006850 G-X-G motif; other site 198215006851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215006852 active site 198215006853 phosphorylation site [posttranslational modification] 198215006854 intermolecular recognition site; other site 198215006855 dimerization interface [polypeptide binding]; other site 198215006856 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198215006857 putative binding surface; other site 198215006858 active site 198215006859 putative CoA-transferase; Provisional; Region: PRK11430 198215006860 CoA-transferase family III; Region: CoA_transf_3; pfam02515 198215006861 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 198215006862 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198215006863 PYR/PP interface [polypeptide binding]; other site 198215006864 dimer interface [polypeptide binding]; other site 198215006865 TPP binding site [chemical binding]; other site 198215006866 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198215006867 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 198215006868 TPP-binding site; other site 198215006869 dimer interface [polypeptide binding]; other site 198215006870 formyl-coenzyme A transferase; Provisional; Region: PRK05398 198215006871 CoA-transferase family III; Region: CoA_transf_3; pfam02515 198215006872 hypothetical protein; Provisional; Region: PRK10316 198215006873 YfdX protein; Region: YfdX; pfam10938 198215006874 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 198215006875 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 198215006876 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198215006877 putative acyl-acceptor binding pocket; other site 198215006878 aminotransferase; Validated; Region: PRK08175 198215006879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215006881 homodimer interface [polypeptide binding]; other site 198215006882 catalytic residue [active] 198215006883 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 198215006884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215006885 active site 198215006886 phosphorylation site [posttranslational modification] 198215006887 intermolecular recognition site; other site 198215006888 dimerization interface [polypeptide binding]; other site 198215006889 LytTr DNA-binding domain; Region: LytTR; pfam04397 198215006890 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198215006891 dimerization domain swap beta strand [polypeptide binding]; other site 198215006892 regulatory protein interface [polypeptide binding]; other site 198215006893 active site 198215006894 regulatory phosphorylation site [posttranslational modification]; other site 198215006895 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 198215006896 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 198215006897 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198215006898 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198215006899 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215006900 active site 198215006901 phosphorylation site [posttranslational modification] 198215006902 exoaminopeptidase; Provisional; Region: PRK09961 198215006903 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 198215006904 oligomer interface [polypeptide binding]; other site 198215006905 active site 198215006906 metal binding site [ion binding]; metal-binding site 198215006907 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 198215006908 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198215006909 active site 198215006910 P-loop; other site 198215006911 phosphorylation site [posttranslational modification] 198215006912 glucokinase, proteobacterial type; Region: glk; TIGR00749 198215006913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198215006914 nucleotide binding site [chemical binding]; other site 198215006915 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 198215006916 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 198215006917 Cl- selectivity filter; other site 198215006918 Cl- binding residues [ion binding]; other site 198215006919 pore gating glutamate residue; other site 198215006920 dimer interface [polypeptide binding]; other site 198215006921 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 198215006922 manganese transport protein MntH; Reviewed; Region: PRK00701 198215006923 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 198215006924 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198215006925 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198215006926 Nucleoside recognition; Region: Gate; pfam07670 198215006927 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198215006928 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 198215006929 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 198215006930 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 198215006931 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 198215006932 active site 198215006933 HIGH motif; other site 198215006934 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 198215006935 active site 198215006936 KMSKS motif; other site 198215006937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198215006938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215006939 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 198215006940 putative dimerization interface [polypeptide binding]; other site 198215006941 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 198215006942 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 198215006943 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 198215006944 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 198215006945 nucleotide binding pocket [chemical binding]; other site 198215006946 K-X-D-G motif; other site 198215006947 catalytic site [active] 198215006948 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 198215006949 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 198215006950 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 198215006951 Dimer interface [polypeptide binding]; other site 198215006952 BRCT sequence motif; other site 198215006953 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 198215006954 cell division protein ZipA; Provisional; Region: PRK03427 198215006955 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 198215006956 FtsZ protein binding site [polypeptide binding]; other site 198215006957 putative sulfate transport protein CysZ; Validated; Region: PRK04949 198215006958 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 198215006959 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198215006960 dimer interface [polypeptide binding]; other site 198215006961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215006962 catalytic residue [active] 198215006963 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198215006964 dimerization domain swap beta strand [polypeptide binding]; other site 198215006965 regulatory protein interface [polypeptide binding]; other site 198215006966 active site 198215006967 regulatory phosphorylation site [posttranslational modification]; other site 198215006968 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 198215006969 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 198215006970 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198215006971 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198215006972 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198215006973 HPr interaction site; other site 198215006974 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198215006975 active site 198215006976 phosphorylation site [posttranslational modification] 198215006977 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 198215006978 dimer interface [polypeptide binding]; other site 198215006979 pyridoxamine kinase; Validated; Region: PRK05756 198215006980 pyridoxal binding site [chemical binding]; other site 198215006981 ATP binding site [chemical binding]; other site 198215006982 hypothetical protein; Provisional; Region: PRK10318 198215006983 cysteine synthase B; Region: cysM; TIGR01138 198215006984 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198215006985 dimer interface [polypeptide binding]; other site 198215006986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215006987 catalytic residue [active] 198215006988 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 198215006989 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 198215006990 Walker A/P-loop; other site 198215006991 ATP binding site [chemical binding]; other site 198215006992 Q-loop/lid; other site 198215006993 ABC transporter signature motif; other site 198215006994 Walker B; other site 198215006995 D-loop; other site 198215006996 H-loop/switch region; other site 198215006997 TOBE-like domain; Region: TOBE_3; pfam12857 198215006998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215006999 putative PBP binding loops; other site 198215007000 ABC-ATPase subunit interface; other site 198215007001 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198215007002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215007003 dimer interface [polypeptide binding]; other site 198215007004 conserved gate region; other site 198215007005 putative PBP binding loops; other site 198215007006 ABC-ATPase subunit interface; other site 198215007007 thiosulfate transporter subunit; Provisional; Region: PRK10852 198215007008 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 198215007009 short chain dehydrogenase; Provisional; Region: PRK08226 198215007010 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 198215007011 NAD binding site [chemical binding]; other site 198215007012 homotetramer interface [polypeptide binding]; other site 198215007013 homodimer interface [polypeptide binding]; other site 198215007014 active site 198215007015 transcriptional regulator MurR; Provisional; Region: PRK15482 198215007016 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198215007017 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198215007018 putative active site [active] 198215007019 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 198215007020 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 198215007021 putative active site [active] 198215007022 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 198215007023 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198215007024 active site turn [active] 198215007025 phosphorylation site [posttranslational modification] 198215007026 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198215007027 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 198215007028 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 198215007029 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 198215007030 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 198215007031 putative acetyltransferase; Provisional; Region: PRK03624 198215007032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215007033 Coenzyme A binding pocket [chemical binding]; other site 198215007034 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 198215007035 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198215007036 active site 198215007037 metal binding site [ion binding]; metal-binding site 198215007038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215007039 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198215007040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215007041 carboxysome structural protein EutK; Provisional; Region: PRK15466 198215007042 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 198215007043 Hexamer interface [polypeptide binding]; other site 198215007044 Hexagonal pore residue; other site 198215007045 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 198215007046 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 198215007047 putative hexamer interface [polypeptide binding]; other site 198215007048 putative hexagonal pore; other site 198215007049 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 198215007050 putative hexamer interface [polypeptide binding]; other site 198215007051 putative hexagonal pore; other site 198215007052 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 198215007053 HNH endonuclease; Region: HNH_3; pfam13392 198215007054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 198215007055 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 198215007056 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215007057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215007058 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215007059 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215007060 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 198215007061 G1 box; other site 198215007062 GTP/Mg2+ binding site [chemical binding]; other site 198215007063 G2 box; other site 198215007064 Switch I region; other site 198215007065 G3 box; other site 198215007066 Switch II region; other site 198215007067 G4 box; other site 198215007068 G5 box; other site 198215007069 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 198215007070 putative hexamer interface [polypeptide binding]; other site 198215007071 putative hexagonal pore; other site 198215007072 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 198215007073 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198215007074 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 198215007075 putative NAD(P) binding site [chemical binding]; other site 198215007076 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 198215007077 transaldolase-like protein; Provisional; Region: PTZ00411 198215007078 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 198215007079 active site 198215007080 dimer interface [polypeptide binding]; other site 198215007081 catalytic residue [active] 198215007082 transketolase; Reviewed; Region: PRK12753 198215007083 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198215007084 TPP-binding site [chemical binding]; other site 198215007085 dimer interface [polypeptide binding]; other site 198215007086 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198215007087 PYR/PP interface [polypeptide binding]; other site 198215007088 dimer interface [polypeptide binding]; other site 198215007089 TPP binding site [chemical binding]; other site 198215007090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198215007091 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 198215007092 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 198215007093 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198215007094 dimer interface [polypeptide binding]; other site 198215007095 ADP-ribose binding site [chemical binding]; other site 198215007096 active site 198215007097 nudix motif; other site 198215007098 metal binding site [ion binding]; metal-binding site 198215007099 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 198215007100 4Fe-4S binding domain; Region: Fer4; pfam00037 198215007101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198215007102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215007103 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 198215007104 Protein export membrane protein; Region: SecD_SecF; cl14618 198215007105 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 198215007106 ArsC family; Region: ArsC; pfam03960 198215007107 putative catalytic residues [active] 198215007108 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 198215007109 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 198215007110 metal binding site [ion binding]; metal-binding site 198215007111 dimer interface [polypeptide binding]; other site 198215007112 putative hydrolase; Provisional; Region: PRK11460 198215007113 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 198215007114 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 198215007115 Helicase; Region: Helicase_RecD; pfam05127 198215007116 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 198215007117 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 198215007118 Predicted metalloprotease [General function prediction only]; Region: COG2321 198215007119 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 198215007120 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 198215007121 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 198215007122 ATP binding site [chemical binding]; other site 198215007123 active site 198215007124 substrate binding site [chemical binding]; other site 198215007125 lipoprotein; Provisional; Region: PRK11679 198215007126 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 198215007127 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 198215007128 dihydrodipicolinate synthase; Region: dapA; TIGR00674 198215007129 dimer interface [polypeptide binding]; other site 198215007130 active site 198215007131 catalytic residue [active] 198215007132 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 198215007133 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 198215007134 catalytic triad [active] 198215007135 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198215007136 4Fe-4S binding domain; Region: Fer4; pfam00037 198215007137 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 198215007138 NADH dehydrogenase; Region: NADHdh; cl00469 198215007139 hydrogenase 4 subunit D; Validated; Region: PRK06525 198215007140 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198215007141 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 198215007142 hydrogenase 4 subunit F; Validated; Region: PRK06458 198215007143 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198215007144 hydrogenase 4 subunit H; Validated; Region: PRK08222 198215007145 4Fe-4S binding domain; Region: Fer4; pfam00037 198215007146 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 198215007147 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 198215007148 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198215007149 Domain of unknown function DUF20; Region: UPF0118; pfam01594 198215007150 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 198215007151 Peptidase family M48; Region: Peptidase_M48; cl12018 198215007152 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 198215007153 ArsC family; Region: ArsC; pfam03960 198215007154 catalytic residues [active] 198215007155 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 198215007156 DNA replication initiation factor; Provisional; Region: PRK08084 198215007157 uracil transporter; Provisional; Region: PRK10720 198215007158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215007159 active site 198215007160 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 198215007161 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 198215007162 dimerization interface [polypeptide binding]; other site 198215007163 putative ATP binding site [chemical binding]; other site 198215007164 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 198215007165 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 198215007166 active site 198215007167 substrate binding site [chemical binding]; other site 198215007168 cosubstrate binding site; other site 198215007169 catalytic site [active] 198215007170 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 198215007171 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 198215007172 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 198215007173 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 198215007174 domain interface [polypeptide binding]; other site 198215007175 active site 198215007176 catalytic site [active] 198215007177 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 198215007178 putative active site [active] 198215007179 catalytic site [active] 198215007180 exopolyphosphatase; Provisional; Region: PRK10854 198215007181 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 198215007182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215007183 Transposase; Region: HTH_Tnp_1; pfam01527 198215007184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215007185 Integrase core domain; Region: rve; pfam00665 198215007186 Integrase core domain; Region: rve_3; pfam13683 198215007187 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 198215007188 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 198215007189 dihydropteroate synthase; Region: DHPS; TIGR01496 198215007190 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 198215007191 substrate binding pocket [chemical binding]; other site 198215007192 dimer interface [polypeptide binding]; other site 198215007193 inhibitor binding site; inhibition site 198215007194 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 198215007195 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198215007196 Putative transposase; Region: Y2_Tnp; pfam04986 198215007197 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 198215007198 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 198215007199 catalytic residues [active] 198215007200 catalytic nucleophile [active] 198215007201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215007202 putative DNA binding site [nucleotide binding]; other site 198215007203 putative Zn2+ binding site [ion binding]; other site 198215007204 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 198215007205 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198215007206 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198215007207 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 198215007208 active site 198215007209 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 198215007210 arsenical-resistance protein; Region: acr3; TIGR00832 198215007211 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 198215007212 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 198215007213 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 198215007214 Replication protein C (RepC); Region: RepC; pfam06504 198215007215 AAA domain; Region: AAA_25; pfam13481 198215007216 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 198215007217 Walker A motif; other site 198215007218 NTP binding site [chemical binding]; other site 198215007219 hexamer interface [polypeptide binding]; other site 198215007220 Walker B motif; other site 198215007221 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 198215007222 integrase; Provisional; Region: PRK09692 198215007223 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198215007224 active site 198215007225 Int/Topo IB signature motif; other site 198215007226 GMP synthase; Reviewed; Region: guaA; PRK00074 198215007227 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 198215007228 AMP/PPi binding site [chemical binding]; other site 198215007229 candidate oxyanion hole; other site 198215007230 catalytic triad [active] 198215007231 potential glutamine specificity residues [chemical binding]; other site 198215007232 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 198215007233 ATP Binding subdomain [chemical binding]; other site 198215007234 Ligand Binding sites [chemical binding]; other site 198215007235 Dimerization subdomain; other site 198215007236 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 198215007237 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 198215007238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 198215007239 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198215007240 active site 198215007241 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 198215007242 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 198215007243 generic binding surface II; other site 198215007244 generic binding surface I; other site 198215007245 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 198215007246 GTP-binding protein Der; Reviewed; Region: PRK00093 198215007247 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 198215007248 G1 box; other site 198215007249 GTP/Mg2+ binding site [chemical binding]; other site 198215007250 Switch I region; other site 198215007251 G2 box; other site 198215007252 Switch II region; other site 198215007253 G3 box; other site 198215007254 G4 box; other site 198215007255 G5 box; other site 198215007256 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 198215007257 G1 box; other site 198215007258 GTP/Mg2+ binding site [chemical binding]; other site 198215007259 Switch I region; other site 198215007260 G2 box; other site 198215007261 G3 box; other site 198215007262 Switch II region; other site 198215007263 G4 box; other site 198215007264 G5 box; other site 198215007265 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 198215007266 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 198215007267 Trp docking motif [polypeptide binding]; other site 198215007268 active site 198215007269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 198215007270 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 198215007271 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 198215007272 dimer interface [polypeptide binding]; other site 198215007273 motif 1; other site 198215007274 active site 198215007275 motif 2; other site 198215007276 motif 3; other site 198215007277 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 198215007278 anticodon binding site; other site 198215007279 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 198215007280 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 198215007281 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 198215007282 cytoskeletal protein RodZ; Provisional; Region: PRK10856 198215007283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215007284 non-specific DNA binding site [nucleotide binding]; other site 198215007285 salt bridge; other site 198215007286 sequence-specific DNA binding site [nucleotide binding]; other site 198215007287 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 198215007288 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 198215007289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215007290 FeS/SAM binding site; other site 198215007291 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 198215007292 active site 198215007293 multimer interface [polypeptide binding]; other site 198215007294 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198215007295 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198215007296 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 198215007297 aminopeptidase B; Provisional; Region: PRK05015 198215007298 Peptidase; Region: DUF3663; pfam12404 198215007299 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 198215007300 interface (dimer of trimers) [polypeptide binding]; other site 198215007301 Substrate-binding/catalytic site; other site 198215007302 Zn-binding sites [ion binding]; other site 198215007303 hypothetical protein; Provisional; Region: PRK10721 198215007304 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 198215007305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198215007306 catalytic loop [active] 198215007307 iron binding site [ion binding]; other site 198215007308 chaperone protein HscA; Provisional; Region: hscA; PRK05183 198215007309 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 198215007310 nucleotide binding site [chemical binding]; other site 198215007311 putative NEF/HSP70 interaction site [polypeptide binding]; other site 198215007312 SBD interface [polypeptide binding]; other site 198215007313 co-chaperone HscB; Provisional; Region: hscB; PRK05014 198215007314 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198215007315 HSP70 interaction site [polypeptide binding]; other site 198215007316 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 198215007317 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 198215007318 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 198215007319 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 198215007320 trimerization site [polypeptide binding]; other site 198215007321 active site 198215007322 cysteine desulfurase; Provisional; Region: PRK14012 198215007323 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 198215007324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198215007325 catalytic residue [active] 198215007326 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 198215007327 Rrf2 family protein; Region: rrf2_super; TIGR00738 198215007328 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 198215007329 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 198215007330 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 198215007331 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 198215007332 active site 198215007333 dimerization interface [polypeptide binding]; other site 198215007334 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 198215007335 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198215007336 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 198215007337 PRD domain; Region: PRD; pfam00874 198215007338 PRD domain; Region: PRD; pfam00874 198215007339 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 198215007340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215007341 putative substrate translocation pore; other site 198215007342 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 198215007343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215007344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215007345 dimerization interface [polypeptide binding]; other site 198215007346 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 198215007347 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 198215007348 iron-sulfur cluster [ion binding]; other site 198215007349 [2Fe-2S] cluster binding site [ion binding]; other site 198215007350 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 198215007351 beta subunit interface [polypeptide binding]; other site 198215007352 alpha subunit interface [polypeptide binding]; other site 198215007353 active site 198215007354 substrate binding site [chemical binding]; other site 198215007355 Fe binding site [ion binding]; other site 198215007356 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 198215007357 inter-subunit interface; other site 198215007358 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 198215007359 [2Fe-2S] cluster binding site [ion binding]; other site 198215007360 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 198215007361 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 198215007362 NAD binding site [chemical binding]; other site 198215007363 active site 198215007364 Predicted membrane protein [Function unknown]; Region: COG2259 198215007365 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 198215007366 active site 198215007367 catalytic residues [active] 198215007368 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 198215007369 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198215007370 putative NAD(P) binding site [chemical binding]; other site 198215007371 catalytic Zn binding site [ion binding]; other site 198215007372 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215007373 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215007374 TM-ABC transporter signature motif; other site 198215007375 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198215007376 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198215007377 Walker A/P-loop; other site 198215007378 ATP binding site [chemical binding]; other site 198215007379 Q-loop/lid; other site 198215007380 ABC transporter signature motif; other site 198215007381 Walker B; other site 198215007382 D-loop; other site 198215007383 H-loop/switch region; other site 198215007384 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198215007385 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 198215007386 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198215007387 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198215007388 nucleotide binding site [chemical binding]; other site 198215007389 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 198215007390 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 198215007391 dimer interface [polypeptide binding]; other site 198215007392 active site 198215007393 glycine-pyridoxal phosphate binding site [chemical binding]; other site 198215007394 folate binding site [chemical binding]; other site 198215007395 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 198215007396 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 198215007397 heme-binding site [chemical binding]; other site 198215007398 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 198215007399 FAD binding pocket [chemical binding]; other site 198215007400 FAD binding motif [chemical binding]; other site 198215007401 phosphate binding motif [ion binding]; other site 198215007402 beta-alpha-beta structure motif; other site 198215007403 NAD binding pocket [chemical binding]; other site 198215007404 Heme binding pocket [chemical binding]; other site 198215007405 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 198215007406 Nitrogen regulatory protein P-II; Region: P-II; smart00938 198215007407 response regulator GlrR; Provisional; Region: PRK15115 198215007408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215007409 active site 198215007410 phosphorylation site [posttranslational modification] 198215007411 intermolecular recognition site; other site 198215007412 dimerization interface [polypeptide binding]; other site 198215007413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215007414 Walker A motif; other site 198215007415 ATP binding site [chemical binding]; other site 198215007416 Walker B motif; other site 198215007417 arginine finger; other site 198215007418 hypothetical protein; Provisional; Region: PRK10722 198215007419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198215007420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215007421 dimer interface [polypeptide binding]; other site 198215007422 phosphorylation site [posttranslational modification] 198215007423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215007424 ATP binding site [chemical binding]; other site 198215007425 Mg2+ binding site [ion binding]; other site 198215007426 G-X-G motif; other site 198215007427 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 198215007428 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 198215007429 dimerization interface [polypeptide binding]; other site 198215007430 ATP binding site [chemical binding]; other site 198215007431 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 198215007432 dimerization interface [polypeptide binding]; other site 198215007433 ATP binding site [chemical binding]; other site 198215007434 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 198215007435 putative active site [active] 198215007436 catalytic triad [active] 198215007437 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 198215007438 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215007439 substrate binding pocket [chemical binding]; other site 198215007440 membrane-bound complex binding site; other site 198215007441 hinge residues; other site 198215007442 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198215007443 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198215007444 catalytic residue [active] 198215007445 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 198215007446 nucleoside/Zn binding site; other site 198215007447 dimer interface [polypeptide binding]; other site 198215007448 catalytic motif [active] 198215007449 hypothetical protein; Provisional; Region: PRK11590 198215007450 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 198215007451 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198215007452 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 198215007453 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198215007454 putative active site [active] 198215007455 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 198215007456 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 198215007457 catalytic residues [active] 198215007458 catalytic nucleophile [active] 198215007459 Presynaptic Site I dimer interface [polypeptide binding]; other site 198215007460 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 198215007461 Synaptic Flat tetramer interface [polypeptide binding]; other site 198215007462 Synaptic Site I dimer interface [polypeptide binding]; other site 198215007463 DNA binding site [nucleotide binding] 198215007464 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198215007465 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 198215007466 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198215007467 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 198215007468 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198215007469 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215007470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215007471 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215007472 HTH-like domain; Region: HTH_21; pfam13276 198215007473 Integrase core domain; Region: rve; pfam00665 198215007474 Integrase core domain; Region: rve_3; pfam13683 198215007475 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 198215007476 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 198215007477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215007478 Transposase; Region: HTH_Tnp_1; pfam01527 198215007479 Integrase core domain; Region: rve; pfam00665 198215007480 Integrase core domain; Region: rve_3; pfam13683 198215007481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198215007482 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 198215007483 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 198215007484 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 198215007485 active site 198215007486 hydrophilic channel; other site 198215007487 dimerization interface [polypeptide binding]; other site 198215007488 catalytic residues [active] 198215007489 active site lid [active] 198215007490 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 198215007491 Recombination protein O N terminal; Region: RecO_N; pfam11967 198215007492 Recombination protein O C terminal; Region: RecO_C; pfam02565 198215007493 GTPase Era; Reviewed; Region: era; PRK00089 198215007494 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 198215007495 G1 box; other site 198215007496 GTP/Mg2+ binding site [chemical binding]; other site 198215007497 Switch I region; other site 198215007498 G2 box; other site 198215007499 Switch II region; other site 198215007500 G3 box; other site 198215007501 G4 box; other site 198215007502 G5 box; other site 198215007503 KH domain; Region: KH_2; pfam07650 198215007504 ribonuclease III; Reviewed; Region: rnc; PRK00102 198215007505 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 198215007506 dimerization interface [polypeptide binding]; other site 198215007507 active site 198215007508 metal binding site [ion binding]; metal-binding site 198215007509 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 198215007510 dsRNA binding site [nucleotide binding]; other site 198215007511 signal peptidase I; Provisional; Region: PRK10861 198215007512 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198215007513 Catalytic site [active] 198215007514 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198215007515 GTP-binding protein LepA; Provisional; Region: PRK05433 198215007516 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 198215007517 G1 box; other site 198215007518 putative GEF interaction site [polypeptide binding]; other site 198215007519 GTP/Mg2+ binding site [chemical binding]; other site 198215007520 Switch I region; other site 198215007521 G2 box; other site 198215007522 G3 box; other site 198215007523 Switch II region; other site 198215007524 G4 box; other site 198215007525 G5 box; other site 198215007526 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 198215007527 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 198215007528 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 198215007529 SoxR reducing system protein RseC; Provisional; Region: PRK10862 198215007530 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 198215007531 anti-sigma E factor; Provisional; Region: rseB; PRK09455 198215007532 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 198215007533 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 198215007534 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 198215007535 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 198215007536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198215007537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198215007538 DNA binding residues [nucleotide binding] 198215007539 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 198215007540 Methyltransferase domain; Region: Methyltransf_26; pfam13659 198215007541 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 198215007542 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198215007543 ATP binding site [chemical binding]; other site 198215007544 Mg++ binding site [ion binding]; other site 198215007545 motif III; other site 198215007546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215007547 nucleotide binding region [chemical binding]; other site 198215007548 ATP-binding site [chemical binding]; other site 198215007549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198215007550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215007551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198215007552 dimerization interface [polypeptide binding]; other site 198215007553 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 198215007554 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 198215007555 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 198215007556 ligand binding site [chemical binding]; other site 198215007557 active site 198215007558 UGI interface [polypeptide binding]; other site 198215007559 catalytic site [active] 198215007560 putative methyltransferase; Provisional; Region: PRK10864 198215007561 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 198215007562 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198215007563 thioredoxin 2; Provisional; Region: PRK10996 198215007564 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 198215007565 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198215007566 catalytic residues [active] 198215007567 Uncharacterized conserved protein [Function unknown]; Region: COG3148 198215007568 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 198215007569 CoA binding domain; Region: CoA_binding_2; pfam13380 198215007570 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 198215007571 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 198215007572 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198215007573 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198215007574 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 198215007575 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 198215007576 domain interface [polypeptide binding]; other site 198215007577 putative active site [active] 198215007578 catalytic site [active] 198215007579 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 198215007580 domain interface [polypeptide binding]; other site 198215007581 putative active site [active] 198215007582 catalytic site [active] 198215007583 lipoprotein; Provisional; Region: PRK10759 198215007584 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 198215007585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215007586 putative substrate translocation pore; other site 198215007587 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215007588 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215007589 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215007590 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 198215007591 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 198215007592 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 198215007593 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215007594 RNA binding surface [nucleotide binding]; other site 198215007595 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198215007596 active site 198215007597 hypothetical protein; Provisional; Region: PRK10723 198215007598 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 198215007599 protein disaggregation chaperone; Provisional; Region: PRK10865 198215007600 Clp amino terminal domain; Region: Clp_N; pfam02861 198215007601 Clp amino terminal domain; Region: Clp_N; pfam02861 198215007602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215007603 Walker A motif; other site 198215007604 ATP binding site [chemical binding]; other site 198215007605 Walker B motif; other site 198215007606 arginine finger; other site 198215007607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215007608 Walker A motif; other site 198215007609 ATP binding site [chemical binding]; other site 198215007610 Walker B motif; other site 198215007611 arginine finger; other site 198215007612 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 198215007613 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215007614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215007615 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215007616 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 198215007617 30S subunit binding site; other site 198215007618 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 198215007619 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 198215007620 Prephenate dehydratase; Region: PDT; pfam00800 198215007621 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 198215007622 putative L-Phe binding site [chemical binding]; other site 198215007623 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 198215007624 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 198215007625 prephenate dehydrogenase; Validated; Region: PRK08507 198215007626 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 198215007627 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198215007628 lipoprotein; Provisional; Region: PRK11443 198215007629 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 198215007630 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 198215007631 putative outer membrane lipoprotein; Provisional; Region: PRK09967 198215007632 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198215007633 ligand binding site [chemical binding]; other site 198215007634 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 198215007635 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 198215007636 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 198215007637 RimM N-terminal domain; Region: RimM; pfam01782 198215007638 PRC-barrel domain; Region: PRC; pfam05239 198215007639 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 198215007640 signal recognition particle protein; Provisional; Region: PRK10867 198215007641 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 198215007642 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198215007643 P loop; other site 198215007644 GTP binding site [chemical binding]; other site 198215007645 Signal peptide binding domain; Region: SRP_SPB; pfam02978 198215007646 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 198215007647 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198215007648 Transporter associated domain; Region: CorC_HlyC; smart01091 198215007649 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 198215007650 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 198215007651 dimer interface [polypeptide binding]; other site 198215007652 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 198215007653 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 198215007654 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 198215007655 recombination and repair protein; Provisional; Region: PRK10869 198215007656 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198215007657 Walker A/P-loop; other site 198215007658 ATP binding site [chemical binding]; other site 198215007659 Q-loop/lid; other site 198215007660 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198215007661 Q-loop/lid; other site 198215007662 ABC transporter signature motif; other site 198215007663 Walker B; other site 198215007664 D-loop; other site 198215007665 H-loop/switch region; other site 198215007666 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 198215007667 hypothetical protein; Validated; Region: PRK01777 198215007668 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 198215007669 putative coenzyme Q binding site [chemical binding]; other site 198215007670 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 198215007671 SmpB-tmRNA interface; other site 198215007672 integrase; Provisional; Region: PRK09692 198215007673 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198215007674 active site 198215007675 Int/Topo IB signature motif; other site 198215007676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215007677 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215007678 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215007679 Transposase; Region: HTH_Tnp_1; cl17663 198215007680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215007681 HTH-like domain; Region: HTH_21; pfam13276 198215007682 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 198215007683 substrate binding pocket [chemical binding]; other site 198215007684 active site 198215007685 iron coordination sites [ion binding]; other site 198215007686 Predicted dehydrogenase [General function prediction only]; Region: COG0579 198215007687 hydroxyglutarate oxidase; Provisional; Region: PRK11728 198215007688 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198215007689 acetylornithine transaminase; Region: PLN00144 198215007690 inhibitor-cofactor binding pocket; inhibition site 198215007691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215007692 catalytic residue [active] 198215007693 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 198215007694 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 198215007695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215007696 DNA-binding site [nucleotide binding]; DNA binding site 198215007697 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198215007698 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 198215007699 bacterial OsmY and nodulation domain; Region: BON; smart00749 198215007700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215007701 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 198215007702 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215007703 HTH-like domain; Region: HTH_21; pfam13276 198215007704 Integrase core domain; Region: rve; pfam00665 198215007705 Integrase core domain; Region: rve_3; pfam13683 198215007706 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215007707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215007708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215007709 dimerization interface [polypeptide binding]; other site 198215007710 putative DNA binding site [nucleotide binding]; other site 198215007711 putative Zn2+ binding site [ion binding]; other site 198215007712 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 198215007713 active site residue [active] 198215007714 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 198215007715 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 198215007716 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 198215007717 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 198215007718 hypothetical protein; Provisional; Region: PRK10556 198215007719 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 198215007720 catalytic residues [active] 198215007721 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 198215007722 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 198215007723 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 198215007724 Class I ribonucleotide reductase; Region: RNR_I; cd01679 198215007725 active site 198215007726 dimer interface [polypeptide binding]; other site 198215007727 catalytic residues [active] 198215007728 effector binding site; other site 198215007729 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 198215007730 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 198215007731 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 198215007732 dimer interface [polypeptide binding]; other site 198215007733 putative radical transfer pathway; other site 198215007734 diiron center [ion binding]; other site 198215007735 tyrosyl radical; other site 198215007736 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 198215007737 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 198215007738 Walker A/P-loop; other site 198215007739 ATP binding site [chemical binding]; other site 198215007740 Q-loop/lid; other site 198215007741 ABC transporter signature motif; other site 198215007742 Walker B; other site 198215007743 D-loop; other site 198215007744 H-loop/switch region; other site 198215007745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 198215007746 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 198215007747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215007748 dimer interface [polypeptide binding]; other site 198215007749 conserved gate region; other site 198215007750 putative PBP binding loops; other site 198215007751 ABC-ATPase subunit interface; other site 198215007752 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 198215007753 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 198215007754 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198215007755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215007756 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 198215007757 putative L-valine exporter; Provisional; Region: PRK10408 198215007758 transcriptional repressor MprA; Provisional; Region: PRK10870 198215007759 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198215007760 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198215007761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215007762 putative substrate translocation pore; other site 198215007763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215007764 S-ribosylhomocysteinase; Provisional; Region: PRK02260 198215007765 glutamate--cysteine ligase; Provisional; Region: PRK02107 198215007766 Predicted membrane protein [Function unknown]; Region: COG1238 198215007767 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 198215007768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215007769 motif II; other site 198215007770 carbon storage regulator; Provisional; Region: PRK01712 198215007771 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 198215007772 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 198215007773 motif 1; other site 198215007774 active site 198215007775 motif 2; other site 198215007776 motif 3; other site 198215007777 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 198215007778 DHHA1 domain; Region: DHHA1; pfam02272 198215007779 recombination regulator RecX; Reviewed; Region: recX; PRK00117 198215007780 recombinase A; Provisional; Region: recA; PRK09354 198215007781 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 198215007782 hexamer interface [polypeptide binding]; other site 198215007783 Walker A motif; other site 198215007784 ATP binding site [chemical binding]; other site 198215007785 Walker B motif; other site 198215007786 hypothetical protein; Validated; Region: PRK03661 198215007787 Transglycosylase SLT domain; Region: SLT_2; pfam13406 198215007788 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198215007789 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198215007790 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 198215007791 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 198215007792 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 198215007793 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 198215007794 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 198215007795 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 198215007796 putative NAD(P) binding site [chemical binding]; other site 198215007797 active site 198215007798 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 198215007799 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 198215007800 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198215007801 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215007802 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 198215007803 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 198215007804 putative active site [active] 198215007805 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 198215007806 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 198215007807 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198215007808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215007809 Walker A motif; other site 198215007810 ATP binding site [chemical binding]; other site 198215007811 Walker B motif; other site 198215007812 arginine finger; other site 198215007813 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 198215007814 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198215007815 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 198215007816 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 198215007817 iron binding site [ion binding]; other site 198215007818 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 198215007819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198215007820 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215007821 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 198215007822 Acylphosphatase; Region: Acylphosphatase; pfam00708 198215007823 HypF finger; Region: zf-HYPF; pfam07503 198215007824 HypF finger; Region: zf-HYPF; pfam07503 198215007825 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 198215007826 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 198215007827 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 198215007828 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198215007829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215007830 DNA binding site [nucleotide binding] 198215007831 domain linker motif; other site 198215007832 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198215007833 dimerization interface (closed form) [polypeptide binding]; other site 198215007834 ligand binding site [chemical binding]; other site 198215007835 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 198215007836 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 198215007837 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 198215007838 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 198215007839 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 198215007840 NADH dehydrogenase; Region: NADHdh; cl00469 198215007841 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 198215007842 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198215007843 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198215007844 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 198215007845 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 198215007846 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 198215007847 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 198215007848 hydrogenase assembly chaperone; Provisional; Region: PRK10409 198215007849 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 198215007850 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 198215007851 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 198215007852 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 198215007853 dimerization interface [polypeptide binding]; other site 198215007854 ATP binding site [chemical binding]; other site 198215007855 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 198215007856 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198215007857 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198215007858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215007859 Walker A motif; other site 198215007860 ATP binding site [chemical binding]; other site 198215007861 Walker B motif; other site 198215007862 arginine finger; other site 198215007863 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 198215007864 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215007865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215007866 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215007867 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215007868 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 198215007869 MutS domain I; Region: MutS_I; pfam01624 198215007870 MutS domain II; Region: MutS_II; pfam05188 198215007871 MutS domain III; Region: MutS_III; pfam05192 198215007872 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 198215007873 Walker A/P-loop; other site 198215007874 ATP binding site [chemical binding]; other site 198215007875 Q-loop/lid; other site 198215007876 ABC transporter signature motif; other site 198215007877 Walker B; other site 198215007878 D-loop; other site 198215007879 H-loop/switch region; other site 198215007880 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198215007881 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198215007882 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215007883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215007884 Transposase; Region: HTH_Tnp_1; pfam01527 198215007885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215007886 Integrase core domain; Region: rve; pfam00665 198215007887 Integrase core domain; Region: rve_3; pfam13683 198215007888 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 198215007889 Integrase core domain; Region: rve; pfam00665 198215007890 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 198215007891 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 198215007892 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 198215007893 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 198215007894 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 198215007895 Flavoprotein; Region: Flavoprotein; pfam02441 198215007896 MarR family; Region: MarR_2; cl17246 198215007897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198215007898 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 198215007899 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215007900 Peptidase family M23; Region: Peptidase_M23; pfam01551 198215007901 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 198215007902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215007903 S-adenosylmethionine binding site [chemical binding]; other site 198215007904 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 198215007905 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 198215007906 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 198215007907 Permutation of conserved domain; other site 198215007908 active site 198215007909 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 198215007910 homotrimer interaction site [polypeptide binding]; other site 198215007911 zinc binding site [ion binding]; other site 198215007912 CDP-binding sites; other site 198215007913 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 198215007914 substrate binding site; other site 198215007915 dimer interface; other site 198215007916 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 198215007917 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 198215007918 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 198215007919 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 198215007920 ligand-binding site [chemical binding]; other site 198215007921 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 198215007922 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 198215007923 CysD dimerization site [polypeptide binding]; other site 198215007924 G1 box; other site 198215007925 putative GEF interaction site [polypeptide binding]; other site 198215007926 GTP/Mg2+ binding site [chemical binding]; other site 198215007927 Switch I region; other site 198215007928 G2 box; other site 198215007929 G3 box; other site 198215007930 Switch II region; other site 198215007931 G4 box; other site 198215007932 G5 box; other site 198215007933 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 198215007934 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 198215007935 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 198215007936 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198215007937 Active Sites [active] 198215007938 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 198215007939 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 198215007940 metal binding site [ion binding]; metal-binding site 198215007941 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 198215007942 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198215007943 Active Sites [active] 198215007944 sulfite reductase subunit beta; Provisional; Region: PRK13504 198215007945 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198215007946 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198215007947 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 198215007948 Flavodoxin; Region: Flavodoxin_1; pfam00258 198215007949 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 198215007950 FAD binding pocket [chemical binding]; other site 198215007951 FAD binding motif [chemical binding]; other site 198215007952 catalytic residues [active] 198215007953 NAD binding pocket [chemical binding]; other site 198215007954 phosphate binding motif [ion binding]; other site 198215007955 beta-alpha-beta structure motif; other site 198215007956 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 198215007957 homohexamer interface [polypeptide binding]; other site 198215007958 putative substrate stabilizing pore; other site 198215007959 pterin binding site; other site 198215007960 putative oxidoreductase FixC; Provisional; Region: PRK10157 198215007961 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 198215007962 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 198215007963 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 198215007964 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 198215007965 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 198215007966 Ligand binding site [chemical binding]; other site 198215007967 Electron transfer flavoprotein domain; Region: ETF; pfam01012 198215007968 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 198215007969 benzoate transport; Region: 2A0115; TIGR00895 198215007970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215007971 putative substrate translocation pore; other site 198215007972 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 198215007973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215007974 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215007975 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215007976 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215007977 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 198215007978 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 198215007979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215007980 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215007981 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215007982 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215007983 enolase; Provisional; Region: eno; PRK00077 198215007984 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 198215007985 dimer interface [polypeptide binding]; other site 198215007986 metal binding site [ion binding]; metal-binding site 198215007987 substrate binding pocket [chemical binding]; other site 198215007988 CTP synthetase; Validated; Region: pyrG; PRK05380 198215007989 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 198215007990 Catalytic site [active] 198215007991 active site 198215007992 UTP binding site [chemical binding]; other site 198215007993 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 198215007994 active site 198215007995 putative oxyanion hole; other site 198215007996 catalytic triad [active] 198215007997 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 198215007998 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 198215007999 homodimer interface [polypeptide binding]; other site 198215008000 metal binding site [ion binding]; metal-binding site 198215008001 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 198215008002 homodimer interface [polypeptide binding]; other site 198215008003 active site 198215008004 putative chemical substrate binding site [chemical binding]; other site 198215008005 metal binding site [ion binding]; metal-binding site 198215008006 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 198215008007 HD domain; Region: HD_4; pfam13328 198215008008 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198215008009 synthetase active site [active] 198215008010 NTP binding site [chemical binding]; other site 198215008011 metal binding site [ion binding]; metal-binding site 198215008012 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 198215008013 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 198215008014 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 198215008015 TRAM domain; Region: TRAM; pfam01938 198215008016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215008017 S-adenosylmethionine binding site [chemical binding]; other site 198215008018 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 198215008019 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 198215008020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215008021 dimerization interface [polypeptide binding]; other site 198215008022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215008023 dimer interface [polypeptide binding]; other site 198215008024 phosphorylation site [posttranslational modification] 198215008025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215008026 ATP binding site [chemical binding]; other site 198215008027 Mg2+ binding site [ion binding]; other site 198215008028 G-X-G motif; other site 198215008029 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 198215008030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215008031 active site 198215008032 phosphorylation site [posttranslational modification] 198215008033 intermolecular recognition site; other site 198215008034 dimerization interface [polypeptide binding]; other site 198215008035 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198215008036 putative binding surface; other site 198215008037 active site 198215008038 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 198215008039 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 198215008040 active site 198215008041 tetramer interface [polypeptide binding]; other site 198215008042 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 198215008043 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 198215008044 active site 198215008045 tetramer interface [polypeptide binding]; other site 198215008046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008047 D-galactonate transporter; Region: 2A0114; TIGR00893 198215008048 putative substrate translocation pore; other site 198215008049 flavodoxin; Provisional; Region: PRK08105 198215008050 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198215008051 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 198215008052 probable active site [active] 198215008053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 198215008054 SecY interacting protein Syd; Provisional; Region: PRK04968 198215008055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 198215008056 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 198215008057 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 198215008058 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 198215008059 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 198215008060 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215008061 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215008062 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215008063 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198215008064 serine transporter; Region: stp; TIGR00814 198215008065 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 198215008066 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198215008067 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198215008068 flap endonuclease-like protein; Provisional; Region: PRK09482 198215008069 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198215008070 active site 198215008071 metal binding site 1 [ion binding]; metal-binding site 198215008072 putative 5' ssDNA interaction site; other site 198215008073 metal binding site 3; metal-binding site 198215008074 metal binding site 2 [ion binding]; metal-binding site 198215008075 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198215008076 putative DNA binding site [nucleotide binding]; other site 198215008077 putative metal binding site [ion binding]; other site 198215008078 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 198215008079 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 198215008080 dimer interface [polypeptide binding]; other site 198215008081 active site 198215008082 metal binding site [ion binding]; metal-binding site 198215008083 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198215008084 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 198215008085 intersubunit interface [polypeptide binding]; other site 198215008086 active site 198215008087 Zn2+ binding site [ion binding]; other site 198215008088 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 198215008089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008090 putative substrate translocation pore; other site 198215008091 L-fucose isomerase; Provisional; Region: fucI; PRK10991 198215008092 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 198215008093 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198215008094 trimer interface [polypeptide binding]; other site 198215008095 substrate binding site [chemical binding]; other site 198215008096 Mn binding site [ion binding]; other site 198215008097 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 198215008098 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 198215008099 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198215008100 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215008101 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 198215008102 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 198215008103 hypothetical protein; Provisional; Region: PRK10873 198215008104 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 198215008105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215008106 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 198215008107 dimerization interface [polypeptide binding]; other site 198215008108 substrate binding pocket [chemical binding]; other site 198215008109 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 198215008110 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 198215008111 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 198215008112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198215008113 catalytic residue [active] 198215008114 CsdA-binding activator; Provisional; Region: PRK15019 198215008115 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 198215008116 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 198215008117 putative ATP binding site [chemical binding]; other site 198215008118 putative substrate interface [chemical binding]; other site 198215008119 murein transglycosylase A; Provisional; Region: mltA; PRK11162 198215008120 MltA specific insert domain; Region: MltA; pfam03562 198215008121 3D domain; Region: 3D; pfam06725 198215008122 AMIN domain; Region: AMIN; pfam11741 198215008123 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198215008124 active site 198215008125 metal binding site [ion binding]; metal-binding site 198215008126 N-acetylglutamate synthase; Validated; Region: PRK05279 198215008127 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 198215008128 putative feedback inhibition sensing region; other site 198215008129 putative nucleotide binding site [chemical binding]; other site 198215008130 putative substrate binding site [chemical binding]; other site 198215008131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215008132 Coenzyme A binding pocket [chemical binding]; other site 198215008133 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 198215008134 AAA domain; Region: AAA_30; pfam13604 198215008135 Family description; Region: UvrD_C_2; pfam13538 198215008136 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 198215008137 protease3; Provisional; Region: PRK15101 198215008138 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 198215008139 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198215008140 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198215008141 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 198215008142 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 198215008143 hypothetical protein; Provisional; Region: PRK10332 198215008144 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 198215008145 hypothetical protein; Provisional; Region: PRK11521 198215008146 hypothetical protein; Provisional; Region: PRK10557 198215008147 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 198215008148 thymidylate synthase; Reviewed; Region: thyA; PRK01827 198215008149 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 198215008150 dimerization interface [polypeptide binding]; other site 198215008151 active site 198215008152 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 198215008153 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 198215008154 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198215008155 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 198215008156 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198215008157 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198215008158 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 198215008159 putative active site [active] 198215008160 Ap4A binding site [chemical binding]; other site 198215008161 nudix motif; other site 198215008162 putative metal binding site [ion binding]; other site 198215008163 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 198215008164 putative DNA-binding cleft [nucleotide binding]; other site 198215008165 putative DNA clevage site; other site 198215008166 molecular lever; other site 198215008167 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198215008168 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 198215008169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198215008170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198215008171 active site 198215008172 catalytic tetrad [active] 198215008173 lysophospholipid transporter LplT; Provisional; Region: PRK11195 198215008174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008175 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 198215008176 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198215008177 putative acyl-acceptor binding pocket; other site 198215008178 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 198215008179 acyl-activating enzyme (AAE) consensus motif; other site 198215008180 putative AMP binding site [chemical binding]; other site 198215008181 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 198215008182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215008183 DNA binding site [nucleotide binding] 198215008184 domain linker motif; other site 198215008185 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198215008186 dimerization interface (closed form) [polypeptide binding]; other site 198215008187 ligand binding site [chemical binding]; other site 198215008188 diaminopimelate decarboxylase; Provisional; Region: PRK11165 198215008189 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 198215008190 active site 198215008191 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198215008192 substrate binding site [chemical binding]; other site 198215008193 catalytic residues [active] 198215008194 dimer interface [polypeptide binding]; other site 198215008195 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 198215008196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215008197 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 198215008198 putative dimerization interface [polypeptide binding]; other site 198215008199 putative racemase; Provisional; Region: PRK10200 198215008200 aspartate racemase; Region: asp_race; TIGR00035 198215008201 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 198215008202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008203 putative substrate translocation pore; other site 198215008204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008205 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 198215008206 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 198215008207 NADP binding site [chemical binding]; other site 198215008208 homodimer interface [polypeptide binding]; other site 198215008209 active site 198215008210 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 198215008211 putative acyltransferase; Provisional; Region: PRK05790 198215008212 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198215008213 dimer interface [polypeptide binding]; other site 198215008214 active site 198215008215 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198215008216 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 198215008217 Transposase; Region: HTH_Tnp_1; cl17663 198215008218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215008219 putative transposase OrfB; Reviewed; Region: PHA02517 198215008220 HTH-like domain; Region: HTH_21; pfam13276 198215008221 Integrase core domain; Region: rve; pfam00665 198215008222 Integrase core domain; Region: rve_2; pfam13333 198215008223 Nop53 (60S ribosomal biogenesis); Region: Nop53; pfam07767 198215008224 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 198215008225 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 198215008226 Int/Topo IB signature motif; other site 198215008227 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198215008228 Peptidase family M23; Region: Peptidase_M23; pfam01551 198215008229 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 198215008230 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 198215008231 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 198215008232 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 198215008233 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 198215008234 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 198215008235 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198215008236 catalytic loop [active] 198215008237 iron binding site [ion binding]; other site 198215008238 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 198215008239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008240 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008241 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008242 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215008243 xanthine permease; Region: pbuX; TIGR03173 198215008244 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 198215008245 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 198215008246 active site 198215008247 metal binding site [ion binding]; metal-binding site 198215008248 nudix motif; other site 198215008249 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 198215008250 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 198215008251 dimer interface [polypeptide binding]; other site 198215008252 putative anticodon binding site; other site 198215008253 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 198215008254 motif 1; other site 198215008255 active site 198215008256 motif 2; other site 198215008257 motif 3; other site 198215008258 peptide chain release factor 2; Validated; Region: prfB; PRK00578 198215008259 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198215008260 RF-1 domain; Region: RF-1; pfam00472 198215008261 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 198215008262 DHH family; Region: DHH; pfam01368 198215008263 DHHA1 domain; Region: DHHA1; pfam02272 198215008264 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 198215008265 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 198215008266 dimerization domain [polypeptide binding]; other site 198215008267 dimer interface [polypeptide binding]; other site 198215008268 catalytic residues [active] 198215008269 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 198215008270 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 198215008271 active site 198215008272 Int/Topo IB signature motif; other site 198215008273 flavodoxin FldB; Provisional; Region: PRK12359 198215008274 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 198215008275 hypothetical protein; Provisional; Region: PRK10878 198215008276 putative global regulator; Reviewed; Region: PRK09559 198215008277 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 198215008278 hemolysin; Provisional; Region: PRK15087 198215008279 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 198215008280 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 198215008281 beta-galactosidase; Region: BGL; TIGR03356 198215008282 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 198215008283 classical (c) SDRs; Region: SDR_c; cd05233 198215008284 NAD(P) binding site [chemical binding]; other site 198215008285 active site 198215008286 glycine dehydrogenase; Provisional; Region: PRK05367 198215008287 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198215008288 tetramer interface [polypeptide binding]; other site 198215008289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215008290 catalytic residue [active] 198215008291 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198215008292 tetramer interface [polypeptide binding]; other site 198215008293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215008294 catalytic residue [active] 198215008295 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 198215008296 lipoyl attachment site [posttranslational modification]; other site 198215008297 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 198215008298 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 198215008299 oxidoreductase; Provisional; Region: PRK08013 198215008300 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 198215008301 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 198215008302 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 198215008303 proline aminopeptidase P II; Provisional; Region: PRK10879 198215008304 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 198215008305 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 198215008306 active site 198215008307 hypothetical protein; Reviewed; Region: PRK01736 198215008308 Z-ring-associated protein; Provisional; Region: PRK10972 198215008309 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 198215008310 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 198215008311 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 198215008312 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 198215008313 ligand binding site [chemical binding]; other site 198215008314 NAD binding site [chemical binding]; other site 198215008315 tetramer interface [polypeptide binding]; other site 198215008316 catalytic site [active] 198215008317 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 198215008318 L-serine binding site [chemical binding]; other site 198215008319 ACT domain interface; other site 198215008320 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 198215008321 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198215008322 active site 198215008323 dimer interface [polypeptide binding]; other site 198215008324 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 198215008325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215008326 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 198215008327 putative dimerization interface [polypeptide binding]; other site 198215008328 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 198215008329 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 198215008330 active site 198215008331 substrate binding site [chemical binding]; other site 198215008332 coenzyme B12 binding site [chemical binding]; other site 198215008333 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 198215008334 B12 binding site [chemical binding]; other site 198215008335 cobalt ligand [ion binding]; other site 198215008336 membrane ATPase/protein kinase; Provisional; Region: PRK09435 198215008337 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 198215008338 Walker A; other site 198215008339 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 198215008340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198215008341 substrate binding site [chemical binding]; other site 198215008342 oxyanion hole (OAH) forming residues; other site 198215008343 trimer interface [polypeptide binding]; other site 198215008344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215008345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198215008346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215008347 dimerization interface [polypeptide binding]; other site 198215008348 Uncharacterized conserved protein [Function unknown]; Region: COG2968 198215008349 oxidative stress defense protein; Provisional; Region: PRK11087 198215008350 arginine exporter protein; Provisional; Region: PRK09304 198215008351 mechanosensitive channel MscS; Provisional; Region: PRK10334 198215008352 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198215008353 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 198215008354 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 198215008355 active site 198215008356 intersubunit interface [polypeptide binding]; other site 198215008357 zinc binding site [ion binding]; other site 198215008358 Na+ binding site [ion binding]; other site 198215008359 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 198215008360 Phosphoglycerate kinase; Region: PGK; pfam00162 198215008361 substrate binding site [chemical binding]; other site 198215008362 hinge regions; other site 198215008363 ADP binding site [chemical binding]; other site 198215008364 catalytic site [active] 198215008365 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 198215008366 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198215008367 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198215008368 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 198215008369 trimer interface [polypeptide binding]; other site 198215008370 putative Zn binding site [ion binding]; other site 198215008371 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 198215008372 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198215008373 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198215008374 Walker A/P-loop; other site 198215008375 ATP binding site [chemical binding]; other site 198215008376 Q-loop/lid; other site 198215008377 ABC transporter signature motif; other site 198215008378 Walker B; other site 198215008379 D-loop; other site 198215008380 H-loop/switch region; other site 198215008381 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198215008382 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198215008383 Walker A/P-loop; other site 198215008384 ATP binding site [chemical binding]; other site 198215008385 Q-loop/lid; other site 198215008386 ABC transporter signature motif; other site 198215008387 Walker B; other site 198215008388 D-loop; other site 198215008389 H-loop/switch region; other site 198215008390 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 198215008391 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 198215008392 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 198215008393 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 198215008394 putative active site [active] 198215008395 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 198215008396 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198215008397 putative NAD(P) binding site [chemical binding]; other site 198215008398 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215008399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008400 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008401 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008402 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 198215008403 SPFH domain / Band 7 family; Region: Band_7; pfam01145 198215008404 transketolase; Reviewed; Region: PRK12753 198215008405 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198215008406 TPP-binding site [chemical binding]; other site 198215008407 dimer interface [polypeptide binding]; other site 198215008408 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198215008409 PYR/PP interface [polypeptide binding]; other site 198215008410 dimer interface [polypeptide binding]; other site 198215008411 TPP binding site [chemical binding]; other site 198215008412 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198215008413 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 198215008414 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 198215008415 agmatinase; Region: agmatinase; TIGR01230 198215008416 oligomer interface [polypeptide binding]; other site 198215008417 putative active site [active] 198215008418 Mn binding site [ion binding]; other site 198215008419 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215008420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008421 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008422 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008423 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 198215008424 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 198215008425 dimer interface [polypeptide binding]; other site 198215008426 active site 198215008427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198215008428 catalytic residues [active] 198215008429 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 198215008430 Virulence promoting factor; Region: YqgB; pfam11036 198215008431 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 198215008432 S-adenosylmethionine synthetase; Validated; Region: PRK05250 198215008433 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 198215008434 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 198215008435 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 198215008436 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 198215008437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008438 putative substrate translocation pore; other site 198215008439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008440 hypothetical protein; Provisional; Region: PRK04860 198215008441 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 198215008442 DNA-specific endonuclease I; Provisional; Region: PRK15137 198215008443 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 198215008444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 198215008445 RNA methyltransferase, RsmE family; Region: TIGR00046 198215008446 glutathione synthetase; Provisional; Region: PRK05246 198215008447 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 198215008448 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 198215008449 hypothetical protein; Validated; Region: PRK00228 198215008450 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 198215008451 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 198215008452 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 198215008453 Walker A motif; other site 198215008454 ATP binding site [chemical binding]; other site 198215008455 Walker B motif; other site 198215008456 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 198215008457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198215008458 catalytic residue [active] 198215008459 YGGT family; Region: YGGT; pfam02325 198215008460 YGGT family; Region: YGGT; pfam02325 198215008461 hypothetical protein; Validated; Region: PRK05090 198215008462 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 198215008463 active site 198215008464 dimerization interface [polypeptide binding]; other site 198215008465 HemN family oxidoreductase; Provisional; Region: PRK05660 198215008466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215008467 FeS/SAM binding site; other site 198215008468 HemN C-terminal domain; Region: HemN_C; pfam06969 198215008469 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 198215008470 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 198215008471 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 198215008472 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 198215008473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008474 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008475 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008476 DctM-like transporters; Region: DctM; pfam06808 198215008477 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 198215008478 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 198215008479 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 198215008480 homodimer interface [polypeptide binding]; other site 198215008481 active site 198215008482 hypothetical protein; Provisional; Region: PRK10626 198215008483 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 198215008484 hypothetical protein; Provisional; Region: PRK11702 198215008485 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 198215008486 adenine DNA glycosylase; Provisional; Region: PRK10880 198215008487 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198215008488 minor groove reading motif; other site 198215008489 helix-hairpin-helix signature motif; other site 198215008490 substrate binding pocket [chemical binding]; other site 198215008491 active site 198215008492 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 198215008493 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 198215008494 DNA binding and oxoG recognition site [nucleotide binding] 198215008495 oxidative damage protection protein; Provisional; Region: PRK05408 198215008496 murein transglycosylase C; Provisional; Region: mltC; PRK11671 198215008497 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 198215008498 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198215008499 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198215008500 catalytic residue [active] 198215008501 nucleoside transporter; Region: 2A0110; TIGR00889 198215008502 ornithine decarboxylase; Provisional; Region: PRK13578 198215008503 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 198215008504 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198215008505 homodimer interface [polypeptide binding]; other site 198215008506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215008507 catalytic residue [active] 198215008508 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198215008509 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 198215008510 integrase; Provisional; Region: PRK09692 198215008511 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198215008512 active site 198215008513 Int/Topo IB signature motif; other site 198215008514 Part of AAA domain; Region: AAA_19; pfam13245 198215008515 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 198215008516 AAA domain; Region: AAA_12; pfam13087 198215008517 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 198215008518 putative active site [active] 198215008519 catalytic site [active] 198215008520 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 198215008521 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198215008522 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 198215008523 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198215008524 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198215008525 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198215008526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 198215008527 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 198215008528 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198215008529 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198215008530 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198215008531 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 198215008532 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 198215008533 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 198215008534 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 198215008535 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 198215008536 putative NTP binding site [chemical binding]; other site 198215008537 Transposase; Region: HTH_Tnp_1; cl17663 198215008538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215008539 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 198215008540 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 198215008541 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 198215008542 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215008543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215008544 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215008545 HTH-like domain; Region: HTH_21; pfam13276 198215008546 Integrase core domain; Region: rve; pfam00665 198215008547 Integrase core domain; Region: rve_3; pfam13683 198215008548 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 198215008549 Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673 198215008550 Predicted GTPase [General function prediction only]; Region: COG3596 198215008551 YfjP GTPase; Region: YfjP; cd11383 198215008552 G1 box; other site 198215008553 GTP/Mg2+ binding site [chemical binding]; other site 198215008554 Switch I region; other site 198215008555 G2 box; other site 198215008556 Switch II region; other site 198215008557 G3 box; other site 198215008558 G4 box; other site 198215008559 G5 box; other site 198215008560 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198215008561 hypothetical protein; Provisional; Region: PRK09945 198215008562 hypothetical protein; Provisional; Region: PRK09945 198215008563 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 198215008564 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198215008565 Autotransporter beta-domain; Region: Autotransporter; smart00869 198215008566 Domain of unknown function (DUF932); Region: DUF932; pfam06067 198215008567 Antirestriction protein; Region: Antirestrict; pfam03230 198215008568 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 198215008569 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 198215008570 MPN+ (JAMM) motif; other site 198215008571 Zinc-binding site [ion binding]; other site 198215008572 Protein of unknown function (DUF987); Region: DUF987; pfam06174 198215008573 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 198215008574 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 198215008575 Methyltransferase domain; Region: Methyltransf_27; pfam13708 198215008576 Transposase; Region: HTH_Tnp_1; cl17663 198215008577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215008578 putative transposase OrfB; Reviewed; Region: PHA02517 198215008579 HTH-like domain; Region: HTH_21; pfam13276 198215008580 Integrase core domain; Region: rve; pfam00665 198215008581 Integrase core domain; Region: rve_2; pfam13333 198215008582 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 198215008583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 198215008584 DNA binding site [nucleotide binding] 198215008585 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215008586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008587 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008588 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008589 glycolate transporter; Provisional; Region: PRK09695 198215008590 L-lactate permease; Region: Lactate_perm; cl00701 198215008591 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 198215008592 active site 198215008593 hypothetical protein; Provisional; Region: PRK09732 198215008594 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 198215008595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215008596 DNA-binding site [nucleotide binding]; DNA binding site 198215008597 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198215008598 acyl-CoA synthetase; Validated; Region: PRK09192 198215008599 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 198215008600 acyl-activating enzyme (AAE) consensus motif; other site 198215008601 active site 198215008602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198215008603 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198215008604 NAD(P) binding site [chemical binding]; other site 198215008605 active site 198215008606 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198215008607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 198215008608 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 198215008609 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198215008610 catalytic residue [active] 198215008611 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 198215008612 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198215008613 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198215008614 Predicted permeases [General function prediction only]; Region: COG0795 198215008615 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 198215008616 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198215008617 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 198215008618 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 198215008619 thymidylate kinase; Validated; Region: tmk; PRK00698 198215008620 active site 198215008621 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198215008622 thymidylate kinase; Region: DTMP_kinase; TIGR00041 198215008623 TMP-binding site; other site 198215008624 ATP-binding site [chemical binding]; other site 198215008625 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 198215008626 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198215008627 TMP-binding site; other site 198215008628 ATP-binding site [chemical binding]; other site 198215008629 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198215008630 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198215008631 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 198215008632 CHAP domain; Region: CHAP; pfam05257 198215008633 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 198215008634 putative S-transferase; Provisional; Region: PRK11752 198215008635 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 198215008636 C-terminal domain interface [polypeptide binding]; other site 198215008637 GSH binding site (G-site) [chemical binding]; other site 198215008638 dimer interface [polypeptide binding]; other site 198215008639 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 198215008640 dimer interface [polypeptide binding]; other site 198215008641 N-terminal domain interface [polypeptide binding]; other site 198215008642 active site 198215008643 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 198215008644 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 198215008645 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 198215008646 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 198215008647 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 198215008648 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 198215008649 putative substrate-binding site; other site 198215008650 nickel binding site [ion binding]; other site 198215008651 hydrogenase 2 large subunit; Provisional; Region: PRK10467 198215008652 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 198215008653 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 198215008654 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 198215008655 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 198215008656 4Fe-4S binding domain; Region: Fer4_6; pfam12837 198215008657 hydrogenase 2 small subunit; Provisional; Region: PRK10468 198215008658 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 198215008659 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 198215008660 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 198215008661 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 198215008662 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198215008663 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198215008664 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198215008665 active site 198215008666 catalytic tetrad [active] 198215008667 hypothetical protein; Provisional; Region: PRK05208 198215008668 oxidoreductase; Provisional; Region: PRK07985 198215008669 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 198215008670 NAD binding site [chemical binding]; other site 198215008671 metal binding site [ion binding]; metal-binding site 198215008672 active site 198215008673 biopolymer transport protein ExbD; Provisional; Region: PRK11267 198215008674 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 198215008675 biopolymer transport protein ExbB; Provisional; Region: PRK10414 198215008676 cystathionine beta-lyase; Provisional; Region: PRK08114 198215008677 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198215008678 homodimer interface [polypeptide binding]; other site 198215008679 substrate-cofactor binding pocket; other site 198215008680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215008681 catalytic residue [active] 198215008682 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198215008683 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 198215008684 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 198215008685 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198215008686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215008687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215008688 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 198215008689 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 198215008690 dimer interface [polypeptide binding]; other site 198215008691 active site 198215008692 metal binding site [ion binding]; metal-binding site 198215008693 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198215008694 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198215008695 active site 198215008696 catalytic tetrad [active] 198215008697 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 198215008698 putative outer membrane lipoprotein; Provisional; Region: PRK09973 198215008699 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 198215008700 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 198215008701 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 198215008702 FtsI repressor; Provisional; Region: PRK10883 198215008703 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 198215008704 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 198215008705 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 198215008706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198215008707 putative acyl-acceptor binding pocket; other site 198215008708 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 198215008709 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198215008710 CAP-like domain; other site 198215008711 active site 198215008712 primary dimer interface [polypeptide binding]; other site 198215008713 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198215008714 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 198215008715 TIGR00156 family protein; Region: TIGR00156 198215008716 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 198215008717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215008718 active site 198215008719 phosphorylation site [posttranslational modification] 198215008720 intermolecular recognition site; other site 198215008721 dimerization interface [polypeptide binding]; other site 198215008722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215008723 DNA binding site [nucleotide binding] 198215008724 sensor protein QseC; Provisional; Region: PRK10337 198215008725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215008726 dimer interface [polypeptide binding]; other site 198215008727 phosphorylation site [posttranslational modification] 198215008728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215008729 ATP binding site [chemical binding]; other site 198215008730 G-X-G motif; other site 198215008731 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 198215008732 Uncharacterized conserved protein [Function unknown]; Region: COG1359 198215008733 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 198215008734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215008735 ATP binding site [chemical binding]; other site 198215008736 Mg2+ binding site [ion binding]; other site 198215008737 G-X-G motif; other site 198215008738 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198215008739 anchoring element; other site 198215008740 dimer interface [polypeptide binding]; other site 198215008741 ATP binding site [chemical binding]; other site 198215008742 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 198215008743 active site 198215008744 metal binding site [ion binding]; metal-binding site 198215008745 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198215008746 esterase YqiA; Provisional; Region: PRK11071 198215008747 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198215008748 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 198215008749 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198215008750 active site 198215008751 metal binding site [ion binding]; metal-binding site 198215008752 hexamer interface [polypeptide binding]; other site 198215008753 putative dehydrogenase; Provisional; Region: PRK11039 198215008754 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 198215008755 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198215008756 dimer interface [polypeptide binding]; other site 198215008757 ADP-ribose binding site [chemical binding]; other site 198215008758 active site 198215008759 nudix motif; other site 198215008760 metal binding site [ion binding]; metal-binding site 198215008761 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 198215008762 hypothetical protein; Provisional; Region: PRK11653 198215008763 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 198215008764 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 198215008765 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 198215008766 putative active site [active] 198215008767 metal binding site [ion binding]; metal-binding site 198215008768 zinc transporter ZupT; Provisional; Region: PRK04201 198215008769 ZIP Zinc transporter; Region: Zip; pfam02535 198215008770 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 198215008771 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 198215008772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 198215008773 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215008774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215008775 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215008776 HTH-like domain; Region: HTH_21; pfam13276 198215008777 Integrase core domain; Region: rve; pfam00665 198215008778 Integrase core domain; Region: rve_3; pfam13683 198215008779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008780 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008781 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008782 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215008783 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 198215008784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008785 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008786 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008787 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 198215008788 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 198215008789 putative ribose interaction site [chemical binding]; other site 198215008790 putative ADP binding site [chemical binding]; other site 198215008791 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 198215008792 active site 198215008793 nucleotide binding site [chemical binding]; other site 198215008794 HIGH motif; other site 198215008795 KMSKS motif; other site 198215008796 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 198215008797 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198215008798 metal binding triad; other site 198215008799 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198215008800 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198215008801 metal binding triad; other site 198215008802 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198215008803 Uncharacterized conserved protein [Function unknown]; Region: COG3025 198215008804 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 198215008805 putative active site [active] 198215008806 putative metal binding residues [ion binding]; other site 198215008807 signature motif; other site 198215008808 putative triphosphate binding site [ion binding]; other site 198215008809 CHAD domain; Region: CHAD; pfam05235 198215008810 SH3 domain-containing protein; Provisional; Region: PRK10884 198215008811 Bacterial SH3 domain homologues; Region: SH3b; smart00287 198215008812 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 198215008813 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 198215008814 active site 198215008815 NTP binding site [chemical binding]; other site 198215008816 metal binding triad [ion binding]; metal-binding site 198215008817 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 198215008818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198215008819 Zn2+ binding site [ion binding]; other site 198215008820 Mg2+ binding site [ion binding]; other site 198215008821 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 198215008822 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 198215008823 homooctamer interface [polypeptide binding]; other site 198215008824 active site 198215008825 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 198215008826 transcriptional activator TtdR; Provisional; Region: PRK09801 198215008827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215008828 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 198215008829 putative effector binding pocket; other site 198215008830 putative dimerization interface [polypeptide binding]; other site 198215008831 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 198215008832 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 198215008833 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198215008834 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 198215008835 transmembrane helices; other site 198215008836 UGMP family protein; Validated; Region: PRK09604 198215008837 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 198215008838 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 198215008839 DNA primase; Validated; Region: dnaG; PRK05667 198215008840 CHC2 zinc finger; Region: zf-CHC2; pfam01807 198215008841 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 198215008842 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 198215008843 active site 198215008844 metal binding site [ion binding]; metal-binding site 198215008845 interdomain interaction site; other site 198215008846 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 198215008847 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 198215008848 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 198215008849 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 198215008850 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 198215008851 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 198215008852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198215008853 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198215008854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198215008855 DNA binding residues [nucleotide binding] 198215008856 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215008857 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215008858 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215008859 Predicted transcriptional regulators [Transcription]; Region: COG1695 198215008860 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 198215008861 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 198215008862 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198215008863 inhibitor-cofactor binding pocket; inhibition site 198215008864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215008865 catalytic residue [active] 198215008866 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 198215008867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215008868 DNA binding site [nucleotide binding] 198215008869 domain linker motif; other site 198215008870 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 198215008871 putative dimerization interface [polypeptide binding]; other site 198215008872 putative ligand binding site [chemical binding]; other site 198215008873 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 198215008874 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 198215008875 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 198215008876 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 198215008877 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 198215008878 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 198215008879 inner membrane transporter YjeM; Provisional; Region: PRK15238 198215008880 alpha-glucosidase; Provisional; Region: PRK10137 198215008881 Protein of unknown function, DUF608; Region: DUF608; pfam04685 198215008882 Trehalase; Region: Trehalase; cl17346 198215008883 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 198215008884 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 198215008885 active site 198215008886 FMN binding site [chemical binding]; other site 198215008887 2,4-decadienoyl-CoA binding site; other site 198215008888 catalytic residue [active] 198215008889 4Fe-4S cluster binding site [ion binding]; other site 198215008890 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 198215008891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215008892 non-specific DNA binding site [nucleotide binding]; other site 198215008893 salt bridge; other site 198215008894 sequence-specific DNA binding site [nucleotide binding]; other site 198215008895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 198215008896 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 198215008897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215008898 S-adenosylmethionine binding site [chemical binding]; other site 198215008899 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 198215008900 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198215008901 putative active site [active] 198215008902 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198215008903 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198215008904 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 198215008905 serine/threonine transporter SstT; Provisional; Region: PRK13628 198215008906 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198215008907 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 198215008908 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 198215008909 galactarate dehydratase; Region: galactar-dH20; TIGR03248 198215008910 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 198215008911 Glucuronate isomerase; Region: UxaC; pfam02614 198215008912 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 198215008913 D-galactonate transporter; Region: 2A0114; TIGR00893 198215008914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008915 putative substrate translocation pore; other site 198215008916 CblD like pilus biogenesis initiator; Region: CblD; cl06460 198215008917 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 198215008918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215008919 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215008920 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215008921 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215008922 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 198215008923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215008924 DNA-binding site [nucleotide binding]; DNA binding site 198215008925 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198215008926 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198215008927 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 198215008928 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 198215008929 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 198215008930 Predicted membrane protein [Function unknown]; Region: COG5393 198215008931 YqjK-like protein; Region: YqjK; pfam13997 198215008932 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 198215008933 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 198215008934 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 198215008935 putative dimer interface [polypeptide binding]; other site 198215008936 N-terminal domain interface [polypeptide binding]; other site 198215008937 putative substrate binding pocket (H-site) [chemical binding]; other site 198215008938 Predicted membrane protein [Function unknown]; Region: COG3152 198215008939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215008940 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 198215008941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198215008942 dimerization interface [polypeptide binding]; other site 198215008943 Pirin-related protein [General function prediction only]; Region: COG1741 198215008944 Pirin; Region: Pirin; pfam02678 198215008945 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 198215008946 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 198215008947 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198215008948 serine transporter; Region: stp; TIGR00814 198215008949 L-serine dehydratase TdcG; Provisional; Region: PRK15040 198215008950 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198215008951 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198215008952 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198215008953 homotrimer interaction site [polypeptide binding]; other site 198215008954 putative active site [active] 198215008955 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 198215008956 Pyruvate formate lyase 1; Region: PFL1; cd01678 198215008957 coenzyme A binding site [chemical binding]; other site 198215008958 active site 198215008959 catalytic residues [active] 198215008960 glycine loop; other site 198215008961 propionate/acetate kinase; Provisional; Region: PRK12379 198215008962 Acetokinase family; Region: Acetate_kinase; cl17229 198215008963 threonine/serine transporter TdcC; Provisional; Region: PRK13629 198215008964 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198215008965 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 198215008966 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198215008967 tetramer interface [polypeptide binding]; other site 198215008968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215008969 catalytic residue [active] 198215008970 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 198215008971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215008972 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 198215008973 putative substrate binding pocket [chemical binding]; other site 198215008974 putative dimerization interface [polypeptide binding]; other site 198215008975 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 198215008976 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 198215008977 glycerate kinase I; Provisional; Region: PRK10342 198215008978 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 198215008979 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 198215008980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215008981 D-galactonate transporter; Region: 2A0114; TIGR00893 198215008982 putative substrate translocation pore; other site 198215008983 galactarate dehydratase; Region: galactar-dH20; TIGR03248 198215008984 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 198215008985 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 198215008986 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 198215008987 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198215008988 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215008989 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 198215008990 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 198215008991 active site 198215008992 phosphorylation site [posttranslational modification] 198215008993 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 198215008994 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 198215008995 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198215008996 active pocket/dimerization site; other site 198215008997 active site 198215008998 phosphorylation site [posttranslational modification] 198215008999 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 198215009000 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198215009001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009002 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009003 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009004 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009005 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 198215009006 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 198215009007 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 198215009008 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198215009009 active site 198215009010 trimer interface [polypeptide binding]; other site 198215009011 allosteric site; other site 198215009012 active site lid [active] 198215009013 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009015 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009016 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009017 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 198215009018 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 198215009019 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 198215009020 Integrase core domain; Region: rve; pfam00665 198215009021 Integrase core domain; Region: rve_3; pfam13683 198215009022 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215009023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215009024 Fimbrial protein; Region: Fimbrial; pfam00419 198215009025 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 198215009026 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 198215009027 putative SAM binding site [chemical binding]; other site 198215009028 putative homodimer interface [polypeptide binding]; other site 198215009029 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 198215009030 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 198215009031 putative ligand binding site [chemical binding]; other site 198215009032 TIGR00252 family protein; Region: TIGR00252 198215009033 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 198215009034 dimer interface [polypeptide binding]; other site 198215009035 active site 198215009036 outer membrane lipoprotein; Provisional; Region: PRK11023 198215009037 BON domain; Region: BON; pfam04972 198215009038 BON domain; Region: BON; pfam04972 198215009039 Predicted permease; Region: DUF318; pfam03773 198215009040 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 198215009041 NADH(P)-binding; Region: NAD_binding_10; pfam13460 198215009042 NAD binding site [chemical binding]; other site 198215009043 active site 198215009044 intracellular protease, PfpI family; Region: PfpI; TIGR01382 198215009045 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 198215009046 proposed catalytic triad [active] 198215009047 conserved cys residue [active] 198215009048 hypothetical protein; Provisional; Region: PRK03467 198215009049 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 198215009050 GIY-YIG motif/motif A; other site 198215009051 putative active site [active] 198215009052 putative metal binding site [ion binding]; other site 198215009053 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198215009054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215009055 Coenzyme A binding pocket [chemical binding]; other site 198215009056 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 198215009057 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198215009058 Peptidase family U32; Region: Peptidase_U32; pfam01136 198215009059 putative protease; Provisional; Region: PRK15447 198215009060 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198215009061 hypothetical protein; Provisional; Region: PRK10508 198215009062 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 198215009063 tryptophan permease; Provisional; Region: PRK10483 198215009064 aromatic amino acid transport protein; Region: araaP; TIGR00837 198215009065 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 198215009066 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198215009067 ATP binding site [chemical binding]; other site 198215009068 Mg++ binding site [ion binding]; other site 198215009069 motif III; other site 198215009070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215009071 nucleotide binding region [chemical binding]; other site 198215009072 ATP-binding site [chemical binding]; other site 198215009073 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 198215009074 putative RNA binding site [nucleotide binding]; other site 198215009075 lipoprotein NlpI; Provisional; Region: PRK11189 198215009076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198215009077 binding surface 198215009078 TPR motif; other site 198215009079 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 198215009080 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 198215009081 RNase E interface [polypeptide binding]; other site 198215009082 trimer interface [polypeptide binding]; other site 198215009083 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 198215009084 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 198215009085 RNase E interface [polypeptide binding]; other site 198215009086 trimer interface [polypeptide binding]; other site 198215009087 active site 198215009088 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 198215009089 putative nucleic acid binding region [nucleotide binding]; other site 198215009090 G-X-X-G motif; other site 198215009091 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 198215009092 RNA binding site [nucleotide binding]; other site 198215009093 domain interface; other site 198215009094 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 198215009095 16S/18S rRNA binding site [nucleotide binding]; other site 198215009096 S13e-L30e interaction site [polypeptide binding]; other site 198215009097 25S rRNA binding site [nucleotide binding]; other site 198215009098 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 198215009099 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 198215009100 RNA binding site [nucleotide binding]; other site 198215009101 active site 198215009102 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 198215009103 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 198215009104 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198215009105 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 198215009106 translation initiation factor IF-2; Region: IF-2; TIGR00487 198215009107 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198215009108 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 198215009109 G1 box; other site 198215009110 putative GEF interaction site [polypeptide binding]; other site 198215009111 GTP/Mg2+ binding site [chemical binding]; other site 198215009112 Switch I region; other site 198215009113 G2 box; other site 198215009114 G3 box; other site 198215009115 Switch II region; other site 198215009116 G4 box; other site 198215009117 G5 box; other site 198215009118 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 198215009119 Translation-initiation factor 2; Region: IF-2; pfam11987 198215009120 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 198215009121 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 198215009122 NusA N-terminal domain; Region: NusA_N; pfam08529 198215009123 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 198215009124 RNA binding site [nucleotide binding]; other site 198215009125 homodimer interface [polypeptide binding]; other site 198215009126 NusA-like KH domain; Region: KH_5; pfam13184 198215009127 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 198215009128 G-X-X-G motif; other site 198215009129 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 198215009130 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 198215009131 ribosome maturation protein RimP; Reviewed; Region: PRK00092 198215009132 Sm and related proteins; Region: Sm_like; cl00259 198215009133 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 198215009134 putative oligomer interface [polypeptide binding]; other site 198215009135 putative RNA binding site [nucleotide binding]; other site 198215009136 argininosuccinate synthase; Validated; Region: PRK05370 198215009137 Sulfatase; Region: Sulfatase; cl17466 198215009138 Preprotein translocase SecG subunit; Region: SecG; pfam03840 198215009139 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 198215009140 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 198215009141 active site 198215009142 substrate binding site [chemical binding]; other site 198215009143 metal binding site [ion binding]; metal-binding site 198215009144 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 198215009145 dihydropteroate synthase; Region: DHPS; TIGR01496 198215009146 substrate binding pocket [chemical binding]; other site 198215009147 dimer interface [polypeptide binding]; other site 198215009148 inhibitor binding site; inhibition site 198215009149 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 198215009150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215009151 Walker A motif; other site 198215009152 ATP binding site [chemical binding]; other site 198215009153 Walker B motif; other site 198215009154 arginine finger; other site 198215009155 Peptidase family M41; Region: Peptidase_M41; pfam01434 198215009156 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 198215009157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215009158 S-adenosylmethionine binding site [chemical binding]; other site 198215009159 RNA-binding protein YhbY; Provisional; Region: PRK10343 198215009160 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 198215009161 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 198215009162 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198215009163 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 198215009164 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 198215009165 GTPase CgtA; Reviewed; Region: obgE; PRK12298 198215009166 GTP1/OBG; Region: GTP1_OBG; pfam01018 198215009167 Obg GTPase; Region: Obg; cd01898 198215009168 G1 box; other site 198215009169 GTP/Mg2+ binding site [chemical binding]; other site 198215009170 Switch I region; other site 198215009171 G2 box; other site 198215009172 G3 box; other site 198215009173 Switch II region; other site 198215009174 G4 box; other site 198215009175 G5 box; other site 198215009176 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198215009177 EamA-like transporter family; Region: EamA; pfam00892 198215009178 EamA-like transporter family; Region: EamA; pfam00892 198215009179 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 198215009180 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 198215009181 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 198215009182 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 198215009183 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198215009184 substrate binding pocket [chemical binding]; other site 198215009185 chain length determination region; other site 198215009186 substrate-Mg2+ binding site; other site 198215009187 catalytic residues [active] 198215009188 aspartate-rich region 1; other site 198215009189 active site lid residues [active] 198215009190 aspartate-rich region 2; other site 198215009191 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 198215009192 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 198215009193 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 198215009194 hinge; other site 198215009195 active site 198215009196 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 198215009197 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 198215009198 anti sigma factor interaction site; other site 198215009199 regulatory phosphorylation site [posttranslational modification]; other site 198215009200 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 198215009201 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 198215009202 mce related protein; Region: MCE; pfam02470 198215009203 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 198215009204 conserved hypothetical integral membrane protein; Region: TIGR00056 198215009205 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 198215009206 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 198215009207 Walker A/P-loop; other site 198215009208 ATP binding site [chemical binding]; other site 198215009209 Q-loop/lid; other site 198215009210 ABC transporter signature motif; other site 198215009211 Walker B; other site 198215009212 D-loop; other site 198215009213 H-loop/switch region; other site 198215009214 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 198215009215 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198215009216 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198215009217 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 198215009218 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 198215009219 putative active site [active] 198215009220 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 198215009221 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 198215009222 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 198215009223 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 198215009224 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 198215009225 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 198215009226 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 198215009227 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 198215009228 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 198215009229 Walker A/P-loop; other site 198215009230 ATP binding site [chemical binding]; other site 198215009231 Q-loop/lid; other site 198215009232 ABC transporter signature motif; other site 198215009233 Walker B; other site 198215009234 D-loop; other site 198215009235 H-loop/switch region; other site 198215009236 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 198215009237 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 198215009238 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 198215009239 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 198215009240 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 198215009241 30S subunit binding site; other site 198215009242 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215009243 active site 198215009244 phosphorylation site [posttranslational modification] 198215009245 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 198215009246 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198215009247 dimerization domain swap beta strand [polypeptide binding]; other site 198215009248 regulatory protein interface [polypeptide binding]; other site 198215009249 active site 198215009250 regulatory phosphorylation site [posttranslational modification]; other site 198215009251 hypothetical protein; Provisional; Region: PRK10345 198215009252 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 198215009253 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 198215009254 conserved cys residue [active] 198215009255 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 198215009256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198215009257 putative active site [active] 198215009258 heme pocket [chemical binding]; other site 198215009259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215009260 dimer interface [polypeptide binding]; other site 198215009261 phosphorylation site [posttranslational modification] 198215009262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215009263 ATP binding site [chemical binding]; other site 198215009264 Mg2+ binding site [ion binding]; other site 198215009265 G-X-G motif; other site 198215009266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215009267 active site 198215009268 phosphorylation site [posttranslational modification] 198215009269 intermolecular recognition site; other site 198215009270 dimerization interface [polypeptide binding]; other site 198215009271 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198215009272 putative binding surface; other site 198215009273 active site 198215009274 radical SAM protein, TIGR01212 family; Region: TIGR01212 198215009275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215009276 FeS/SAM binding site; other site 198215009277 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 198215009278 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 198215009279 active site 198215009280 dimer interface [polypeptide binding]; other site 198215009281 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 198215009282 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 198215009283 active site 198215009284 FMN binding site [chemical binding]; other site 198215009285 substrate binding site [chemical binding]; other site 198215009286 3Fe-4S cluster binding site [ion binding]; other site 198215009287 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 198215009288 domain interface; other site 198215009289 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 198215009290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198215009291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215009292 Integrase core domain; Region: rve; pfam00665 198215009293 Integrase core domain; Region: rve_3; pfam13683 198215009294 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 198215009295 N-acetylmannosamine kinase; Provisional; Region: PRK05082 198215009296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198215009297 nucleotide binding site [chemical binding]; other site 198215009298 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198215009299 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 198215009300 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 198215009301 putative active site cavity [active] 198215009302 putative sialic acid transporter; Provisional; Region: PRK03893 198215009303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215009304 putative substrate translocation pore; other site 198215009305 N-acetylneuraminate lyase; Region: nanA; TIGR00683 198215009306 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 198215009307 inhibitor site; inhibition site 198215009308 active site 198215009309 dimer interface [polypeptide binding]; other site 198215009310 catalytic residue [active] 198215009311 transcriptional regulator NanR; Provisional; Region: PRK03837 198215009312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215009313 DNA-binding site [nucleotide binding]; DNA binding site 198215009314 FCD domain; Region: FCD; pfam07729 198215009315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009316 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009317 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009318 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009319 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 198215009320 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 198215009321 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 198215009322 stringent starvation protein A; Provisional; Region: sspA; PRK09481 198215009323 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 198215009324 C-terminal domain interface [polypeptide binding]; other site 198215009325 putative GSH binding site (G-site) [chemical binding]; other site 198215009326 dimer interface [polypeptide binding]; other site 198215009327 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 198215009328 dimer interface [polypeptide binding]; other site 198215009329 N-terminal domain interface [polypeptide binding]; other site 198215009330 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 198215009331 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 198215009332 23S rRNA interface [nucleotide binding]; other site 198215009333 L3 interface [polypeptide binding]; other site 198215009334 Predicted ATPase [General function prediction only]; Region: COG1485 198215009335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 198215009336 hypothetical protein; Provisional; Region: PRK11677 198215009337 serine endoprotease; Provisional; Region: PRK10898 198215009338 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198215009339 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198215009340 malate dehydrogenase; Provisional; Region: PRK05086 198215009341 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 198215009342 NAD binding site [chemical binding]; other site 198215009343 dimerization interface [polypeptide binding]; other site 198215009344 Substrate binding site [chemical binding]; other site 198215009345 arginine repressor; Provisional; Region: PRK05066 198215009346 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 198215009347 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 198215009348 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198215009349 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 198215009350 RNAase interaction site [polypeptide binding]; other site 198215009351 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 198215009352 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198215009353 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 198215009354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215009355 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215009356 efflux system membrane protein; Provisional; Region: PRK11594 198215009357 transcriptional regulator; Provisional; Region: PRK10632 198215009358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215009359 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198215009360 putative effector binding pocket; other site 198215009361 dimerization interface [polypeptide binding]; other site 198215009362 protease TldD; Provisional; Region: tldD; PRK10735 198215009363 hypothetical protein; Provisional; Region: PRK10899 198215009364 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198215009365 ribonuclease G; Provisional; Region: PRK11712 198215009366 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 198215009367 homodimer interface [polypeptide binding]; other site 198215009368 oligonucleotide binding site [chemical binding]; other site 198215009369 Maf-like protein; Region: Maf; pfam02545 198215009370 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 198215009371 active site 198215009372 dimer interface [polypeptide binding]; other site 198215009373 rod shape-determining protein MreD; Provisional; Region: PRK11060 198215009374 rod shape-determining protein MreC; Region: mreC; TIGR00219 198215009375 rod shape-determining protein MreC; Region: MreC; pfam04085 198215009376 rod shape-determining protein MreB; Provisional; Region: PRK13927 198215009377 MreB and similar proteins; Region: MreB_like; cd10225 198215009378 nucleotide binding site [chemical binding]; other site 198215009379 Mg binding site [ion binding]; other site 198215009380 putative protofilament interaction site [polypeptide binding]; other site 198215009381 RodZ interaction site [polypeptide binding]; other site 198215009382 regulatory protein CsrD; Provisional; Region: PRK11059 198215009383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198215009384 metal binding site [ion binding]; metal-binding site 198215009385 active site 198215009386 I-site; other site 198215009387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198215009388 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 198215009389 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 198215009390 NADP binding site [chemical binding]; other site 198215009391 dimer interface [polypeptide binding]; other site 198215009392 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 198215009393 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198215009394 carboxyltransferase (CT) interaction site; other site 198215009395 biotinylation site [posttranslational modification]; other site 198215009396 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 198215009397 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198215009398 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198215009399 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198215009400 hypothetical protein; Provisional; Region: PRK10633 198215009401 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 198215009402 Na binding site [ion binding]; other site 198215009403 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 198215009404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198215009405 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198215009406 active site 198215009407 FMN binding site [chemical binding]; other site 198215009408 catalytic residues [active] 198215009409 substrate binding site [chemical binding]; other site 198215009410 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 198215009411 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 198215009412 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 198215009413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215009414 DNA methylase; Region: N6_N4_Mtase; pfam01555 198215009415 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009417 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009418 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009419 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 198215009420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215009421 substrate binding pocket [chemical binding]; other site 198215009422 membrane-bound complex binding site; other site 198215009423 hinge residues; other site 198215009424 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009426 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009427 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009428 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198215009429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215009430 dimer interface [polypeptide binding]; other site 198215009431 conserved gate region; other site 198215009432 putative PBP binding loops; other site 198215009433 ABC-ATPase subunit interface; other site 198215009434 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198215009435 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198215009436 Walker A/P-loop; other site 198215009437 ATP binding site [chemical binding]; other site 198215009438 Q-loop/lid; other site 198215009439 ABC transporter signature motif; other site 198215009440 Walker B; other site 198215009441 D-loop; other site 198215009442 H-loop/switch region; other site 198215009443 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 198215009444 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 198215009445 trimer interface [polypeptide binding]; other site 198215009446 putative metal binding site [ion binding]; other site 198215009447 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 198215009448 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 198215009449 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 198215009450 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 198215009451 shikimate binding site; other site 198215009452 NAD(P) binding site [chemical binding]; other site 198215009453 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 198215009454 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198215009455 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 198215009456 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198215009457 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198215009458 hypothetical protein; Validated; Region: PRK03430 198215009459 hypothetical protein; Provisional; Region: PRK10736 198215009460 DNA protecting protein DprA; Region: dprA; TIGR00732 198215009461 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 198215009462 active site 198215009463 catalytic residues [active] 198215009464 metal binding site [ion binding]; metal-binding site 198215009465 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 198215009466 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 198215009467 putative active site [active] 198215009468 substrate binding site [chemical binding]; other site 198215009469 putative cosubstrate binding site; other site 198215009470 catalytic site [active] 198215009471 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 198215009472 substrate binding site [chemical binding]; other site 198215009473 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 198215009474 putative RNA binding site [nucleotide binding]; other site 198215009475 16S rRNA methyltransferase B; Provisional; Region: PRK10901 198215009476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215009477 S-adenosylmethionine binding site [chemical binding]; other site 198215009478 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 198215009479 TrkA-N domain; Region: TrkA_N; pfam02254 198215009480 TrkA-C domain; Region: TrkA_C; pfam02080 198215009481 TrkA-N domain; Region: TrkA_N; pfam02254 198215009482 TrkA-C domain; Region: TrkA_C; pfam02080 198215009483 Homeodomain-like domain; Region: HTH_23; pfam13384 198215009484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215009485 Transposase; Region: HTH_Tnp_1; pfam01527 198215009486 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215009487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215009488 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198215009489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215009490 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 198215009491 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215009492 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215009493 aspartate kinase III; Validated; Region: PRK09084 198215009494 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 198215009495 nucleotide binding site [chemical binding]; other site 198215009496 substrate binding site [chemical binding]; other site 198215009497 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 198215009498 lysine allosteric regulatory site; other site 198215009499 dimer interface [polypeptide binding]; other site 198215009500 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 198215009501 dimer interface [polypeptide binding]; other site 198215009502 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 198215009503 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 198215009504 active site 198215009505 dimer interface [polypeptide binding]; other site 198215009506 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 198215009507 dimer interface [polypeptide binding]; other site 198215009508 active site 198215009509 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 198215009510 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 198215009511 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 198215009512 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 198215009513 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 198215009514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215009515 putative substrate translocation pore; other site 198215009516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215009517 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198215009518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215009519 dimer interface [polypeptide binding]; other site 198215009520 conserved gate region; other site 198215009521 putative PBP binding loops; other site 198215009522 ABC-ATPase subunit interface; other site 198215009523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215009524 dimer interface [polypeptide binding]; other site 198215009525 conserved gate region; other site 198215009526 putative PBP binding loops; other site 198215009527 ABC-ATPase subunit interface; other site 198215009528 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 198215009529 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 198215009530 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 198215009531 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 198215009532 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198215009533 Walker A/P-loop; other site 198215009534 ATP binding site [chemical binding]; other site 198215009535 Q-loop/lid; other site 198215009536 ABC transporter signature motif; other site 198215009537 Walker B; other site 198215009538 D-loop; other site 198215009539 H-loop/switch region; other site 198215009540 TOBE domain; Region: TOBE_2; pfam08402 198215009541 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 198215009542 trimer interface; other site 198215009543 sugar binding site [chemical binding]; other site 198215009544 maltose regulon periplasmic protein; Provisional; Region: PRK10564 198215009545 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 198215009546 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 198215009547 UbiA prenyltransferase family; Region: UbiA; pfam01040 198215009548 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 198215009549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 198215009550 putative acyl-acceptor binding pocket; other site 198215009551 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 198215009552 LexA repressor; Validated; Region: PRK00215 198215009553 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 198215009554 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 198215009555 Catalytic site [active] 198215009556 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 198215009557 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 198215009558 hypothetical protein; Provisional; Region: PRK10428 198215009559 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198215009560 metal binding site 2 [ion binding]; metal-binding site 198215009561 putative DNA binding helix; other site 198215009562 metal binding site 1 [ion binding]; metal-binding site 198215009563 dimer interface [polypeptide binding]; other site 198215009564 structural Zn2+ binding site [ion binding]; other site 198215009565 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 198215009566 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 198215009567 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198215009568 FMN binding site [chemical binding]; other site 198215009569 active site 198215009570 catalytic residues [active] 198215009571 substrate binding site [chemical binding]; other site 198215009572 phage shock protein G; Reviewed; Region: pspG; PRK09459 198215009573 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 198215009574 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 198215009575 NADP binding site [chemical binding]; other site 198215009576 dimer interface [polypeptide binding]; other site 198215009577 replicative DNA helicase; Provisional; Region: PRK08006 198215009578 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 198215009579 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 198215009580 Walker A motif; other site 198215009581 ATP binding site [chemical binding]; other site 198215009582 Walker B motif; other site 198215009583 DNA binding loops [nucleotide binding] 198215009584 alanine racemase; Reviewed; Region: alr; PRK00053 198215009585 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 198215009586 active site 198215009587 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198215009588 substrate binding site [chemical binding]; other site 198215009589 catalytic residues [active] 198215009590 dimer interface [polypeptide binding]; other site 198215009591 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 198215009592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215009593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215009594 homodimer interface [polypeptide binding]; other site 198215009595 catalytic residue [active] 198215009596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215009597 active site 198215009598 motif I; other site 198215009599 motif II; other site 198215009600 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 198215009601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 198215009602 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 198215009603 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198215009604 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198215009605 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 198215009606 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 198215009607 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198215009608 dimer interface [polypeptide binding]; other site 198215009609 ssDNA binding site [nucleotide binding]; other site 198215009610 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198215009611 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 198215009612 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009614 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009615 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009616 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 198215009617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215009618 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 198215009619 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 198215009620 DNA binding residues [nucleotide binding] 198215009621 dimer interface [polypeptide binding]; other site 198215009622 [2Fe-2S] cluster binding site [ion binding]; other site 198215009623 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198215009624 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 198215009625 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 198215009626 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198215009627 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 198215009628 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 198215009629 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 198215009630 Na binding site [ion binding]; other site 198215009631 Predicted membrane protein [Function unknown]; Region: COG3162 198215009632 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 198215009633 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 198215009634 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 198215009635 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 198215009636 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 198215009637 heme lyase subunit NrfE; Provisional; Region: PRK10369 198215009638 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 198215009639 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 198215009640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198215009641 binding surface 198215009642 TPR motif; other site 198215009643 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 198215009644 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198215009645 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198215009646 Sel1-like repeats; Region: SEL1; smart00671 198215009647 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 198215009648 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 198215009649 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198215009650 multidrug resistance protein MdtN; Provisional; Region: PRK10476 198215009651 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215009652 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215009653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009654 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009655 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009656 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009657 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 198215009658 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 198215009659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 198215009660 substrate binding pocket [chemical binding]; other site 198215009661 membrane-bound complex binding site; other site 198215009662 hinge residues; other site 198215009663 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 198215009664 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 198215009665 Walker A/P-loop; other site 198215009666 ATP binding site [chemical binding]; other site 198215009667 Q-loop/lid; other site 198215009668 ABC transporter signature motif; other site 198215009669 Walker B; other site 198215009670 D-loop; other site 198215009671 H-loop/switch region; other site 198215009672 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 198215009673 dimer interface [polypeptide binding]; other site 198215009674 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198215009675 hypothetical protein; Provisional; Region: PRK10220 198215009676 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 198215009677 PhnA protein; Region: PhnA; pfam03831 198215009678 hypothetical protein; Provisional; Region: PRK09866 198215009679 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 198215009680 G1 box; other site 198215009681 GTP/Mg2+ binding site [chemical binding]; other site 198215009682 G2 box; other site 198215009683 Switch I region; other site 198215009684 G3 box; other site 198215009685 Switch II region; other site 198215009686 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 198215009687 G2 box; other site 198215009688 Switch I region; other site 198215009689 G3 box; other site 198215009690 Switch II region; other site 198215009691 G4 box; other site 198215009692 G5 box; other site 198215009693 YjcZ-like protein; Region: YjcZ; pfam13990 198215009694 proline/glycine betaine transporter; Provisional; Region: PRK10642 198215009695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215009696 putative substrate translocation pore; other site 198215009697 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 198215009698 sensor protein BasS/PmrB; Provisional; Region: PRK10755 198215009699 HAMP domain; Region: HAMP; pfam00672 198215009700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215009701 dimer interface [polypeptide binding]; other site 198215009702 phosphorylation site [posttranslational modification] 198215009703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215009704 ATP binding site [chemical binding]; other site 198215009705 Mg2+ binding site [ion binding]; other site 198215009706 G-X-G motif; other site 198215009707 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 198215009708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215009709 active site 198215009710 phosphorylation site [posttranslational modification] 198215009711 intermolecular recognition site; other site 198215009712 dimerization interface [polypeptide binding]; other site 198215009713 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215009714 DNA binding site [nucleotide binding] 198215009715 putative metal dependent hydrolase; Provisional; Region: PRK11598 198215009716 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198215009717 Sulfatase; Region: Sulfatase; pfam00884 198215009718 arginine:agmatin antiporter; Provisional; Region: PRK10644 198215009719 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198215009720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215009721 arginine decarboxylase; Provisional; Region: PRK15029 198215009722 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 198215009723 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198215009724 homodimer interface [polypeptide binding]; other site 198215009725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215009726 catalytic residue [active] 198215009727 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198215009728 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 198215009729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215009730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215009731 alpha-galactosidase; Provisional; Region: PRK15076 198215009732 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 198215009733 NAD binding site [chemical binding]; other site 198215009734 sugar binding site [chemical binding]; other site 198215009735 divalent metal binding site [ion binding]; other site 198215009736 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 198215009737 dimer interface [polypeptide binding]; other site 198215009738 melibiose:sodium symporter; Provisional; Region: PRK10429 198215009739 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 198215009740 hypothetical protein; Provisional; Region: PRK09867 198215009741 fumarate hydratase; Provisional; Region: PRK15389 198215009742 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 198215009743 Fumarase C-terminus; Region: Fumerase_C; pfam05683 198215009744 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 198215009745 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 198215009746 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 198215009747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215009748 active site 198215009749 phosphorylation site [posttranslational modification] 198215009750 intermolecular recognition site; other site 198215009751 dimerization interface [polypeptide binding]; other site 198215009752 Transcriptional regulator; Region: CitT; pfam12431 198215009753 sensory histidine kinase DcuS; Provisional; Region: PRK11086 198215009754 PAS domain; Region: PAS; smart00091 198215009755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215009756 ATP binding site [chemical binding]; other site 198215009757 Mg2+ binding site [ion binding]; other site 198215009758 G-X-G motif; other site 198215009759 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215009760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215009761 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215009762 HTH-like domain; Region: HTH_21; pfam13276 198215009763 Integrase core domain; Region: rve; pfam00665 198215009764 Integrase core domain; Region: rve_3; pfam13683 198215009765 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 198215009766 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215009767 RNA binding surface [nucleotide binding]; other site 198215009768 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 198215009769 probable active site [active] 198215009770 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 198215009771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215009772 putative DNA binding site [nucleotide binding]; other site 198215009773 putative Zn2+ binding site [ion binding]; other site 198215009774 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 198215009775 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 198215009776 classical (c) SDRs; Region: SDR_c; cd05233 198215009777 NAD(P) binding site [chemical binding]; other site 198215009778 active site 198215009779 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198215009780 active pocket/dimerization site; other site 198215009781 active site 198215009782 phosphorylation site [posttranslational modification] 198215009783 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 198215009784 active site 198215009785 phosphorylation site [posttranslational modification] 198215009786 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 198215009787 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 198215009788 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 198215009789 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198215009790 putative NAD(P) binding site [chemical binding]; other site 198215009791 catalytic Zn binding site [ion binding]; other site 198215009792 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 198215009793 active site pocket [active] 198215009794 oxyanion hole [active] 198215009795 catalytic triad [active] 198215009796 active site nucleophile [active] 198215009797 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 198215009798 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 198215009799 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 198215009800 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 198215009801 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 198215009802 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 198215009803 substrate binding pocket [chemical binding]; other site 198215009804 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 198215009805 B12 binding site [chemical binding]; other site 198215009806 cobalt ligand [ion binding]; other site 198215009807 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 198215009808 transcriptional repressor IclR; Provisional; Region: PRK11569 198215009809 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198215009810 Bacterial transcriptional regulator; Region: IclR; pfam01614 198215009811 isocitrate lyase; Provisional; Region: PRK15063 198215009812 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 198215009813 tetramer interface [polypeptide binding]; other site 198215009814 active site 198215009815 Mg2+/Mn2+ binding site [ion binding]; other site 198215009816 homoserine O-succinyltransferase; Provisional; Region: PRK05368 198215009817 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 198215009818 proposed active site lysine [active] 198215009819 conserved cys residue [active] 198215009820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198215009821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215009822 Coenzyme A binding pocket [chemical binding]; other site 198215009823 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 198215009824 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 198215009825 purine monophosphate binding site [chemical binding]; other site 198215009826 dimer interface [polypeptide binding]; other site 198215009827 putative catalytic residues [active] 198215009828 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 198215009829 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 198215009830 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 198215009831 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 198215009832 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 198215009833 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 198215009834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215009835 active site 198215009836 phosphorylation site [posttranslational modification] 198215009837 intermolecular recognition site; other site 198215009838 dimerization interface [polypeptide binding]; other site 198215009839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215009840 Walker A motif; other site 198215009841 ATP binding site [chemical binding]; other site 198215009842 Walker B motif; other site 198215009843 arginine finger; other site 198215009844 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198215009845 sensor protein ZraS; Provisional; Region: PRK10364 198215009846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215009847 dimer interface [polypeptide binding]; other site 198215009848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215009849 ATP binding site [chemical binding]; other site 198215009850 Mg2+ binding site [ion binding]; other site 198215009851 G-X-G motif; other site 198215009852 zinc resistance protein; Provisional; Region: zraP; PRK11546 198215009853 dimer interface [polypeptide binding]; other site 198215009854 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 198215009855 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198215009856 IHF dimer interface [polypeptide binding]; other site 198215009857 IHF - DNA interface [nucleotide binding]; other site 198215009858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 198215009859 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 198215009860 Active_site [active] 198215009861 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 198215009862 substrate binding site [chemical binding]; other site 198215009863 active site 198215009864 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 198215009865 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 198215009866 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 198215009867 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 198215009868 putative NADH binding site [chemical binding]; other site 198215009869 putative active site [active] 198215009870 nudix motif; other site 198215009871 putative metal binding site [ion binding]; other site 198215009872 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 198215009873 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 198215009874 ThiC-associated domain; Region: ThiC-associated; pfam13667 198215009875 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 198215009876 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 198215009877 thiamine phosphate binding site [chemical binding]; other site 198215009878 active site 198215009879 pyrophosphate binding site [ion binding]; other site 198215009880 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198215009881 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 198215009882 ATP binding site [chemical binding]; other site 198215009883 substrate interface [chemical binding]; other site 198215009884 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 198215009885 ThiS interaction site; other site 198215009886 putative active site [active] 198215009887 tetramer interface [polypeptide binding]; other site 198215009888 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 198215009889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215009890 FeS/SAM binding site; other site 198215009891 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 198215009892 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 198215009893 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 198215009894 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 198215009895 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 198215009896 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 198215009897 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 198215009898 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 198215009899 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 198215009900 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 198215009901 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 198215009902 DNA binding site [nucleotide binding] 198215009903 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 198215009904 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 198215009905 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 198215009906 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 198215009907 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 198215009908 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 198215009909 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 198215009910 RPB3 interaction site [polypeptide binding]; other site 198215009911 RPB1 interaction site [polypeptide binding]; other site 198215009912 RPB11 interaction site [polypeptide binding]; other site 198215009913 RPB10 interaction site [polypeptide binding]; other site 198215009914 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 198215009915 core dimer interface [polypeptide binding]; other site 198215009916 peripheral dimer interface [polypeptide binding]; other site 198215009917 L10 interface [polypeptide binding]; other site 198215009918 L11 interface [polypeptide binding]; other site 198215009919 putative EF-Tu interaction site [polypeptide binding]; other site 198215009920 putative EF-G interaction site [polypeptide binding]; other site 198215009921 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 198215009922 23S rRNA interface [nucleotide binding]; other site 198215009923 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 198215009924 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 198215009925 mRNA/rRNA interface [nucleotide binding]; other site 198215009926 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 198215009927 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 198215009928 23S rRNA interface [nucleotide binding]; other site 198215009929 L7/L12 interface [polypeptide binding]; other site 198215009930 putative thiostrepton binding site; other site 198215009931 L25 interface [polypeptide binding]; other site 198215009932 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 198215009933 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 198215009934 putative homodimer interface [polypeptide binding]; other site 198215009935 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 198215009936 heterodimer interface [polypeptide binding]; other site 198215009937 homodimer interface [polypeptide binding]; other site 198215009938 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 198215009939 elongation factor Tu; Reviewed; Region: PRK00049 198215009940 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 198215009941 G1 box; other site 198215009942 GEF interaction site [polypeptide binding]; other site 198215009943 GTP/Mg2+ binding site [chemical binding]; other site 198215009944 Switch I region; other site 198215009945 G2 box; other site 198215009946 G3 box; other site 198215009947 Switch II region; other site 198215009948 G4 box; other site 198215009949 G5 box; other site 198215009950 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 198215009951 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 198215009952 Antibiotic Binding Site [chemical binding]; other site 198215009953 pantothenate kinase; Provisional; Region: PRK05439 198215009954 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 198215009955 ATP-binding site [chemical binding]; other site 198215009956 CoA-binding site [chemical binding]; other site 198215009957 Mg2+-binding site [ion binding]; other site 198215009958 Biotin operon repressor [Transcription]; Region: BirA; COG1654 198215009959 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 198215009960 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 198215009961 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 198215009962 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 198215009963 FAD binding domain; Region: FAD_binding_4; pfam01565 198215009964 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 198215009965 glutamate racemase; Provisional; Region: PRK00865 198215009966 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 198215009967 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198215009968 N-terminal plug; other site 198215009969 ligand-binding site [chemical binding]; other site 198215009970 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 198215009971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215009972 S-adenosylmethionine binding site [chemical binding]; other site 198215009973 hypothetical protein; Provisional; Region: PRK11056 198215009974 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 198215009975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215009976 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 198215009977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215009978 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 198215009979 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 198215009980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215009981 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 198215009982 dimerization interface [polypeptide binding]; other site 198215009983 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215009984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215009985 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215009986 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215009987 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 198215009988 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 198215009989 putative active site pocket [active] 198215009990 putative metal binding site [ion binding]; other site 198215009991 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215009992 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215009993 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215009994 argininosuccinate lyase; Provisional; Region: PRK04833 198215009995 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 198215009996 active sites [active] 198215009997 tetramer interface [polypeptide binding]; other site 198215009998 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 198215009999 nucleotide binding site [chemical binding]; other site 198215010000 N-acetyl-L-glutamate binding site [chemical binding]; other site 198215010001 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 198215010002 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 198215010003 acetylornithine deacetylase; Provisional; Region: PRK05111 198215010004 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 198215010005 metal binding site [ion binding]; metal-binding site 198215010006 putative dimer interface [polypeptide binding]; other site 198215010007 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 198215010008 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 198215010009 hypothetical protein; Provisional; Region: PRK10649 198215010010 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198215010011 Sulfatase; Region: Sulfatase; pfam00884 198215010012 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198215010013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215010014 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198215010015 active site 198215010016 P-loop; other site 198215010017 phosphorylation site [posttranslational modification] 198215010018 pyruvate formate lyase II activase; Provisional; Region: PRK10076 198215010019 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 198215010020 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 198215010021 dimer interface [polypeptide binding]; other site 198215010022 active site 198215010023 glycine loop; other site 198215010024 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198215010025 active site 198215010026 P-loop; other site 198215010027 phosphorylation site [posttranslational modification] 198215010028 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 198215010029 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 198215010030 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 198215010031 heme binding site [chemical binding]; other site 198215010032 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 198215010033 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 198215010034 FAD binding site [chemical binding]; other site 198215010035 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 198215010036 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 198215010037 putative catalytic residues [active] 198215010038 putative nucleotide binding site [chemical binding]; other site 198215010039 putative aspartate binding site [chemical binding]; other site 198215010040 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 198215010041 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198215010042 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198215010043 cystathionine gamma-synthase; Provisional; Region: PRK08045 198215010044 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198215010045 homodimer interface [polypeptide binding]; other site 198215010046 substrate-cofactor binding pocket; other site 198215010047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215010048 catalytic residue [active] 198215010049 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 198215010050 dimerization interface [polypeptide binding]; other site 198215010051 DNA binding site [nucleotide binding] 198215010052 corepressor binding sites; other site 198215010053 hypothetical protein; Provisional; Region: PRK10030 198215010054 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 198215010055 primosome assembly protein PriA; Validated; Region: PRK05580 198215010056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215010057 ATP binding site [chemical binding]; other site 198215010058 putative Mg++ binding site [ion binding]; other site 198215010059 helicase superfamily c-terminal domain; Region: HELICc; smart00490 198215010060 ATP-binding site [chemical binding]; other site 198215010061 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215010062 DNA binding site [nucleotide binding] 198215010063 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 198215010064 domain linker motif; other site 198215010065 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 198215010066 dimerization interface [polypeptide binding]; other site 198215010067 ligand binding site [chemical binding]; other site 198215010068 essential cell division protein FtsN; Provisional; Region: PRK10927 198215010069 cell division protein FtsN; Provisional; Region: PRK12757 198215010070 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 198215010071 active site 198215010072 HslU subunit interaction site [polypeptide binding]; other site 198215010073 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 198215010074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215010075 Walker A motif; other site 198215010076 ATP binding site [chemical binding]; other site 198215010077 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 198215010078 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198215010079 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 198215010080 UbiA prenyltransferase family; Region: UbiA; pfam01040 198215010081 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 198215010082 septal ring assembly protein ZapB; Provisional; Region: PRK15422 198215010083 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 198215010084 amphipathic channel; other site 198215010085 Asn-Pro-Ala signature motifs; other site 198215010086 glycerol kinase; Provisional; Region: glpK; PRK00047 198215010087 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 198215010088 N- and C-terminal domain interface [polypeptide binding]; other site 198215010089 active site 198215010090 MgATP binding site [chemical binding]; other site 198215010091 catalytic site [active] 198215010092 metal binding site [ion binding]; metal-binding site 198215010093 glycerol binding site [chemical binding]; other site 198215010094 homotetramer interface [polypeptide binding]; other site 198215010095 homodimer interface [polypeptide binding]; other site 198215010096 FBP binding site [chemical binding]; other site 198215010097 protein IIAGlc interface [polypeptide binding]; other site 198215010098 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 198215010099 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 198215010100 putative active site [active] 198215010101 ferredoxin-NADP reductase; Provisional; Region: PRK10926 198215010102 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 198215010103 FAD binding pocket [chemical binding]; other site 198215010104 FAD binding motif [chemical binding]; other site 198215010105 phosphate binding motif [ion binding]; other site 198215010106 beta-alpha-beta structure motif; other site 198215010107 NAD binding pocket [chemical binding]; other site 198215010108 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198215010109 Ligand Binding Site [chemical binding]; other site 198215010110 hypothetical protein; Provisional; Region: PRK09981 198215010111 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 198215010112 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 198215010113 triosephosphate isomerase; Provisional; Region: PRK14567 198215010114 substrate binding site [chemical binding]; other site 198215010115 dimer interface [polypeptide binding]; other site 198215010116 catalytic triad [active] 198215010117 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 198215010118 sulfate transporter subunit; Provisional; Region: PRK10752 198215010119 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 198215010120 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 198215010121 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 198215010122 active site 198215010123 ADP/pyrophosphate binding site [chemical binding]; other site 198215010124 dimerization interface [polypeptide binding]; other site 198215010125 allosteric effector site; other site 198215010126 fructose-1,6-bisphosphate binding site; other site 198215010127 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 198215010128 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 198215010129 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 198215010130 dimer interface [polypeptide binding]; other site 198215010131 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 198215010132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215010133 active site 198215010134 intermolecular recognition site; other site 198215010135 dimerization interface [polypeptide binding]; other site 198215010136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215010137 DNA binding site [nucleotide binding] 198215010138 two-component sensor protein; Provisional; Region: cpxA; PRK09470 198215010139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215010140 dimerization interface [polypeptide binding]; other site 198215010141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215010142 dimer interface [polypeptide binding]; other site 198215010143 phosphorylation site [posttranslational modification] 198215010144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215010145 ATP binding site [chemical binding]; other site 198215010146 Mg2+ binding site [ion binding]; other site 198215010147 G-X-G motif; other site 198215010148 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 198215010149 MOSC domain; Region: MOSC; pfam03473 198215010150 3-alpha domain; Region: 3-alpha; pfam03475 198215010151 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215010152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215010153 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215010154 HTH-like domain; Region: HTH_21; pfam13276 198215010155 Integrase core domain; Region: rve; pfam00665 198215010156 Integrase core domain; Region: rve_3; pfam13683 198215010157 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 198215010158 superoxide dismutase; Provisional; Region: PRK10925 198215010159 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198215010160 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198215010161 transcriptional activator RhaR; Provisional; Region: PRK13500 198215010162 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198215010163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215010164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215010165 transcriptional activator RhaS; Provisional; Region: PRK13503 198215010166 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198215010167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215010168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215010169 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 198215010170 N- and C-terminal domain interface [polypeptide binding]; other site 198215010171 active site 198215010172 putative catalytic site [active] 198215010173 metal binding site [ion binding]; metal-binding site 198215010174 ATP binding site [chemical binding]; other site 198215010175 rhamnulokinase; Provisional; Region: rhaB; PRK10640 198215010176 carbohydrate binding site [chemical binding]; other site 198215010177 L-rhamnose isomerase; Provisional; Region: PRK01076 198215010178 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 198215010179 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 198215010180 active site 198215010181 intersubunit interface [polypeptide binding]; other site 198215010182 Zn2+ binding site [ion binding]; other site 198215010183 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 198215010184 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215010185 active site 198215010186 phosphorylation site [posttranslational modification] 198215010187 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 198215010188 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198215010189 active site 198215010190 P-loop; other site 198215010191 phosphorylation site [posttranslational modification] 198215010192 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 198215010193 putative peptidase; Provisional; Region: PRK09864 198215010194 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 198215010195 oligomer interface [polypeptide binding]; other site 198215010196 active site 198215010197 metal binding site [ion binding]; metal-binding site 198215010198 HTH domain; Region: HTH_11; pfam08279 198215010199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010200 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010201 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010202 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215010203 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 198215010204 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 198215010205 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198215010206 [4Fe-4S] binding site [ion binding]; other site 198215010207 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198215010208 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198215010209 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 198215010210 molybdopterin cofactor binding site; other site 198215010211 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 198215010212 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 198215010213 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 198215010214 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 198215010215 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 198215010216 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 198215010217 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 198215010218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010219 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010220 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010221 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215010222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215010223 Coenzyme A binding pocket [chemical binding]; other site 198215010224 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 198215010225 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 198215010226 putative active site [active] 198215010227 dimerization interface [polypeptide binding]; other site 198215010228 putative tRNAtyr binding site [nucleotide binding]; other site 198215010229 hypothetical protein; Reviewed; Region: PRK01637 198215010230 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 198215010231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215010232 motif II; other site 198215010233 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198215010234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215010235 putative DNA binding site [nucleotide binding]; other site 198215010236 putative Zn2+ binding site [ion binding]; other site 198215010237 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215010238 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215010239 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 198215010240 substrate binding site [chemical binding]; other site 198215010241 ATP binding site [chemical binding]; other site 198215010242 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 198215010243 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 198215010244 Class I aldolases; Region: Aldolase_Class_I; cl17187 198215010245 catalytic residue [active] 198215010246 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 198215010247 dimerization interface [polypeptide binding]; other site 198215010248 putative active cleft [active] 198215010249 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 198215010250 active site 198215010251 catalytic residues [active] 198215010252 alpha-glucosidase; Provisional; Region: PRK10426 198215010253 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 198215010254 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 198215010255 putative active site [active] 198215010256 putative catalytic site [active] 198215010257 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 198215010258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010259 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215010260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010261 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010262 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010264 putative substrate translocation pore; other site 198215010265 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198215010266 transcriptional regulator protein; Region: phnR; TIGR03337 198215010267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215010268 DNA-binding site [nucleotide binding]; DNA binding site 198215010269 UTRA domain; Region: UTRA; pfam07702 198215010270 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 198215010271 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 198215010272 G1 box; other site 198215010273 putative GEF interaction site [polypeptide binding]; other site 198215010274 GTP/Mg2+ binding site [chemical binding]; other site 198215010275 Switch I region; other site 198215010276 G2 box; other site 198215010277 G3 box; other site 198215010278 Switch II region; other site 198215010279 G4 box; other site 198215010280 G5 box; other site 198215010281 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 198215010282 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 198215010283 glutamine synthetase; Provisional; Region: glnA; PRK09469 198215010284 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 198215010285 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 198215010286 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 198215010287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198215010288 putative active site [active] 198215010289 heme pocket [chemical binding]; other site 198215010290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215010291 dimer interface [polypeptide binding]; other site 198215010292 phosphorylation site [posttranslational modification] 198215010293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215010294 ATP binding site [chemical binding]; other site 198215010295 Mg2+ binding site [ion binding]; other site 198215010296 G-X-G motif; other site 198215010297 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 198215010298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215010299 active site 198215010300 phosphorylation site [posttranslational modification] 198215010301 intermolecular recognition site; other site 198215010302 dimerization interface [polypeptide binding]; other site 198215010303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215010304 Walker A motif; other site 198215010305 ATP binding site [chemical binding]; other site 198215010306 Walker B motif; other site 198215010307 arginine finger; other site 198215010308 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198215010309 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 198215010310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215010311 FeS/SAM binding site; other site 198215010312 HemN C-terminal domain; Region: HemN_C; pfam06969 198215010313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 198215010314 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 198215010315 G1 box; other site 198215010316 GTP/Mg2+ binding site [chemical binding]; other site 198215010317 Switch I region; other site 198215010318 G2 box; other site 198215010319 G3 box; other site 198215010320 Switch II region; other site 198215010321 G4 box; other site 198215010322 G5 box; other site 198215010323 DNA polymerase I; Provisional; Region: PRK05755 198215010324 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198215010325 active site 198215010326 metal binding site 1 [ion binding]; metal-binding site 198215010327 putative 5' ssDNA interaction site; other site 198215010328 metal binding site 3; metal-binding site 198215010329 metal binding site 2 [ion binding]; metal-binding site 198215010330 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198215010331 putative DNA binding site [nucleotide binding]; other site 198215010332 putative metal binding site [ion binding]; other site 198215010333 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 198215010334 active site 198215010335 catalytic site [active] 198215010336 substrate binding site [chemical binding]; other site 198215010337 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 198215010338 active site 198215010339 DNA binding site [nucleotide binding] 198215010340 catalytic site [active] 198215010341 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 198215010342 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 198215010343 putative acyl-acceptor binding pocket; other site 198215010344 hypothetical protein; Provisional; Region: PRK11367 198215010345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 198215010346 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 198215010347 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 198215010348 catalytic residues [active] 198215010349 hinge region; other site 198215010350 alpha helical domain; other site 198215010351 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 198215010352 serine/threonine protein kinase; Provisional; Region: PRK11768 198215010353 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 198215010354 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 198215010355 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 198215010356 GTP binding site; other site 198215010357 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 198215010358 Walker A motif; other site 198215010359 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 198215010360 potassium transporter; Provisional; Region: PRK10750 198215010361 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 198215010362 hypothetical protein; Provisional; Region: PRK11568 198215010363 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 198215010364 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 198215010365 proline dipeptidase; Provisional; Region: PRK13607 198215010366 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 198215010367 active site 198215010368 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 198215010369 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198215010370 substrate binding site [chemical binding]; other site 198215010371 oxyanion hole (OAH) forming residues; other site 198215010372 trimer interface [polypeptide binding]; other site 198215010373 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198215010374 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198215010375 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198215010376 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 198215010377 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198215010378 dimer interface [polypeptide binding]; other site 198215010379 active site 198215010380 FMN reductase; Validated; Region: fre; PRK08051 198215010381 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 198215010382 FAD binding pocket [chemical binding]; other site 198215010383 FAD binding motif [chemical binding]; other site 198215010384 phosphate binding motif [ion binding]; other site 198215010385 beta-alpha-beta structure motif; other site 198215010386 NAD binding pocket [chemical binding]; other site 198215010387 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 198215010388 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 198215010389 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 198215010390 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 198215010391 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198215010392 active site 198215010393 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 198215010394 sec-independent translocase; Provisional; Region: PRK01770 198215010395 sec-independent translocase; Provisional; Region: tatB; PRK00404 198215010396 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 198215010397 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 198215010398 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 198215010399 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 198215010400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 198215010401 SCP-2 sterol transfer family; Region: SCP2; pfam02036 198215010402 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 198215010403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215010404 S-adenosylmethionine binding site [chemical binding]; other site 198215010405 DNA recombination protein RmuC; Provisional; Region: PRK10361 198215010406 RmuC family; Region: RmuC; pfam02646 198215010407 uridine phosphorylase; Provisional; Region: PRK11178 198215010408 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 198215010409 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 198215010410 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 198215010411 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 198215010412 THF binding site; other site 198215010413 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 198215010414 substrate binding site [chemical binding]; other site 198215010415 THF binding site; other site 198215010416 zinc-binding site [ion binding]; other site 198215010417 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 198215010418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215010419 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 198215010420 putative dimerization interface [polypeptide binding]; other site 198215010421 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198215010422 EamA-like transporter family; Region: EamA; pfam00892 198215010423 putative hydrolase; Provisional; Region: PRK10976 198215010424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215010425 active site 198215010426 motif I; other site 198215010427 motif II; other site 198215010428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215010429 lysophospholipase L2; Provisional; Region: PRK10749 198215010430 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198215010431 LysE type translocator; Region: LysE; cl00565 198215010432 LysE type translocator; Region: LysE; cl00565 198215010433 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 198215010434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215010435 ATP binding site [chemical binding]; other site 198215010436 putative Mg++ binding site [ion binding]; other site 198215010437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215010438 nucleotide binding region [chemical binding]; other site 198215010439 ATP-binding site [chemical binding]; other site 198215010440 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 198215010441 Helicase and RNase D C-terminal; Region: HRDC; smart00341 198215010442 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 198215010443 dimerization interface [polypeptide binding]; other site 198215010444 substrate binding site [chemical binding]; other site 198215010445 active site 198215010446 calcium binding site [ion binding]; other site 198215010447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198215010448 CoenzymeA binding site [chemical binding]; other site 198215010449 subunit interaction site [polypeptide binding]; other site 198215010450 PHB binding site; other site 198215010451 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 198215010452 EamA-like transporter family; Region: EamA; cl17759 198215010453 hypothetical protein; Provisional; Region: PRK11371 198215010454 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 198215010455 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 198215010456 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 198215010457 Cl binding site [ion binding]; other site 198215010458 oligomer interface [polypeptide binding]; other site 198215010459 Predicted periplasmic protein [Function unknown]; Region: COG3698 198215010460 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215010461 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215010462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215010463 Predicted periplasmic protein [Function unknown]; Region: COG3698 198215010464 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 198215010465 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 198215010466 Part of AAA domain; Region: AAA_19; pfam13245 198215010467 Family description; Region: UvrD_C_2; pfam13538 198215010468 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 198215010469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215010470 motif II; other site 198215010471 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 198215010472 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198215010473 active site 198215010474 DNA binding site [nucleotide binding] 198215010475 Int/Topo IB signature motif; other site 198215010476 hypothetical protein; Provisional; Region: PRK10963 198215010477 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 198215010478 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198215010479 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198215010480 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 198215010481 DKNYY family; Region: DKNYY; pfam13644 198215010482 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215010483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010484 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010485 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010486 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 198215010487 putative iron binding site [ion binding]; other site 198215010488 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 198215010489 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 198215010490 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 198215010491 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 198215010492 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 198215010493 domain interfaces; other site 198215010494 active site 198215010495 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 198215010496 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 198215010497 active site 198215010498 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 198215010499 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 198215010500 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 198215010501 HemY protein N-terminus; Region: HemY_N; pfam07219 198215010502 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215010503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215010504 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215010505 HTH-like domain; Region: HTH_21; pfam13276 198215010506 Integrase core domain; Region: rve; pfam00665 198215010507 Integrase core domain; Region: rve_3; pfam13683 198215010508 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 198215010509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215010510 FeS/SAM binding site; other site 198215010511 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 198215010512 putative transport protein YifK; Provisional; Region: PRK10746 198215010513 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 198215010514 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 198215010515 putative common antigen polymerase; Provisional; Region: PRK02975 198215010516 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 198215010517 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198215010518 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 198215010519 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 198215010520 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 198215010521 inhibitor-cofactor binding pocket; inhibition site 198215010522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215010523 catalytic residue [active] 198215010524 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 198215010525 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 198215010526 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 198215010527 substrate binding site; other site 198215010528 tetramer interface; other site 198215010529 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 198215010530 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 198215010531 NAD binding site [chemical binding]; other site 198215010532 substrate binding site [chemical binding]; other site 198215010533 homodimer interface [polypeptide binding]; other site 198215010534 active site 198215010535 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 198215010536 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 198215010537 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 198215010538 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 198215010539 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 198215010540 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 198215010541 active site 198215010542 homodimer interface [polypeptide binding]; other site 198215010543 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 198215010544 Chain length determinant protein; Region: Wzz; pfam02706 198215010545 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 198215010546 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 198215010547 Mg++ binding site [ion binding]; other site 198215010548 putative catalytic motif [active] 198215010549 substrate binding site [chemical binding]; other site 198215010550 transcription termination factor Rho; Provisional; Region: rho; PRK09376 198215010551 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 198215010552 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 198215010553 RNA binding site [nucleotide binding]; other site 198215010554 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 198215010555 multimer interface [polypeptide binding]; other site 198215010556 Walker A motif; other site 198215010557 ATP binding site [chemical binding]; other site 198215010558 Walker B motif; other site 198215010559 putative rho operon leader peptide; Provisional; Region: PRK09979 198215010560 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198215010561 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 198215010562 catalytic residues [active] 198215010563 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 198215010564 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198215010565 ATP binding site [chemical binding]; other site 198215010566 Mg++ binding site [ion binding]; other site 198215010567 motif III; other site 198215010568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215010569 nucleotide binding region [chemical binding]; other site 198215010570 ATP-binding site [chemical binding]; other site 198215010571 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 198215010572 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 198215010573 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 198215010574 Part of AAA domain; Region: AAA_19; pfam13245 198215010575 Family description; Region: UvrD_C_2; pfam13538 198215010576 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 198215010577 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 198215010578 ketol-acid reductoisomerase; Validated; Region: PRK05225 198215010579 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 198215010580 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 198215010581 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 198215010582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215010583 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 198215010584 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 198215010585 putative dimerization interface [polypeptide binding]; other site 198215010586 threonine dehydratase; Reviewed; Region: PRK09224 198215010587 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198215010588 tetramer interface [polypeptide binding]; other site 198215010589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215010590 catalytic residue [active] 198215010591 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 198215010592 putative Ile/Val binding site [chemical binding]; other site 198215010593 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 198215010594 putative Ile/Val binding site [chemical binding]; other site 198215010595 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 198215010596 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 198215010597 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 198215010598 homodimer interface [polypeptide binding]; other site 198215010599 substrate-cofactor binding pocket; other site 198215010600 catalytic residue [active] 198215010601 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 198215010602 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 198215010603 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198215010604 PYR/PP interface [polypeptide binding]; other site 198215010605 dimer interface [polypeptide binding]; other site 198215010606 TPP binding site [chemical binding]; other site 198215010607 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198215010608 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198215010609 TPP-binding site [chemical binding]; other site 198215010610 dimer interface [polypeptide binding]; other site 198215010611 ilvG operon leader peptide; Provisional; Region: PRK10424 198215010612 hypothetical protein; Provisional; Region: PRK11027 198215010613 transcriptional regulator HdfR; Provisional; Region: PRK03601 198215010614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215010615 LysR substrate binding domain; Region: LysR_substrate; pfam03466 198215010616 dimerization interface [polypeptide binding]; other site 198215010617 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198215010618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215010619 DNA-binding site [nucleotide binding]; DNA binding site 198215010620 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198215010621 putative transporter; Provisional; Region: PRK10504 198215010622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010623 putative substrate translocation pore; other site 198215010624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010625 transcriptional repressor RbsR; Provisional; Region: PRK10423 198215010626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215010627 DNA binding site [nucleotide binding] 198215010628 domain linker motif; other site 198215010629 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 198215010630 dimerization interface [polypeptide binding]; other site 198215010631 ligand binding site [chemical binding]; other site 198215010632 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 198215010633 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215010634 substrate binding site [chemical binding]; other site 198215010635 dimer interface [polypeptide binding]; other site 198215010636 ATP binding site [chemical binding]; other site 198215010637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215010638 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215010639 TM-ABC transporter signature motif; other site 198215010640 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215010641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010642 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010643 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010644 D-ribose pyranase; Provisional; Region: PRK11797 198215010645 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 198215010646 potassium uptake protein; Region: kup; TIGR00794 198215010647 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215010648 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215010649 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215010650 regulatory ATPase RavA; Provisional; Region: PRK13531 198215010651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215010652 Walker A motif; other site 198215010653 ATP binding site [chemical binding]; other site 198215010654 Walker B motif; other site 198215010655 arginine finger; other site 198215010656 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 198215010657 hypothetical protein; Provisional; Region: yieM; PRK10997 198215010658 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 198215010659 metal ion-dependent adhesion site (MIDAS); other site 198215010660 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 198215010661 dimer interface [polypeptide binding]; other site 198215010662 active site 198215010663 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 198215010664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215010665 putative DNA binding site [nucleotide binding]; other site 198215010666 putative Zn2+ binding site [ion binding]; other site 198215010667 AsnC family; Region: AsnC_trans_reg; pfam01037 198215010668 FMN-binding protein MioC; Provisional; Region: PRK09004 198215010669 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 198215010670 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 198215010671 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 198215010672 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 198215010673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215010674 S-adenosylmethionine binding site [chemical binding]; other site 198215010675 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 198215010676 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 198215010677 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 198215010678 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 198215010679 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 198215010680 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 198215010681 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 198215010682 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 198215010683 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 198215010684 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198215010685 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 198215010686 beta subunit interaction interface [polypeptide binding]; other site 198215010687 Walker A motif; other site 198215010688 ATP binding site [chemical binding]; other site 198215010689 Walker B motif; other site 198215010690 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198215010691 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 198215010692 core domain interface [polypeptide binding]; other site 198215010693 delta subunit interface [polypeptide binding]; other site 198215010694 epsilon subunit interface [polypeptide binding]; other site 198215010695 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 198215010696 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198215010697 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 198215010698 alpha subunit interaction interface [polypeptide binding]; other site 198215010699 Walker A motif; other site 198215010700 ATP binding site [chemical binding]; other site 198215010701 Walker B motif; other site 198215010702 inhibitor binding site; inhibition site 198215010703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198215010704 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 198215010705 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 198215010706 gamma subunit interface [polypeptide binding]; other site 198215010707 epsilon subunit interface [polypeptide binding]; other site 198215010708 LBP interface [polypeptide binding]; other site 198215010709 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 198215010710 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 198215010711 Substrate binding site; other site 198215010712 Mg++ binding site; other site 198215010713 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 198215010714 active site 198215010715 substrate binding site [chemical binding]; other site 198215010716 CoA binding site [chemical binding]; other site 198215010717 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 198215010718 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 198215010719 glutaminase active site [active] 198215010720 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 198215010721 dimer interface [polypeptide binding]; other site 198215010722 active site 198215010723 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 198215010724 dimer interface [polypeptide binding]; other site 198215010725 active site 198215010726 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215010727 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215010728 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215010729 fimbrial protein; Provisional; Region: lpfA; PRK15289 198215010730 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215010731 HTH-like domain; Region: HTH_21; pfam13276 198215010732 Integrase core domain; Region: rve; pfam00665 198215010733 Integrase core domain; Region: rve_3; pfam13683 198215010734 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215010735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215010736 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 198215010737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215010738 Integrase core domain; Region: rve; pfam00665 198215010739 Integrase core domain; Region: rve_3; pfam13683 198215010740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215010741 Transposase; Region: HTH_Tnp_1; pfam01527 198215010742 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 198215010743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010744 putative substrate translocation pore; other site 198215010745 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 198215010746 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198215010747 cryptic adenine deaminase; Provisional; Region: PRK10027 198215010748 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198215010749 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 198215010750 active site 198215010751 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 198215010752 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 198215010753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010754 putative substrate translocation pore; other site 198215010755 regulatory protein UhpC; Provisional; Region: PRK11663 198215010756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010757 putative substrate translocation pore; other site 198215010758 sensory histidine kinase UhpB; Provisional; Region: PRK11644 198215010759 MASE1; Region: MASE1; pfam05231 198215010760 Histidine kinase; Region: HisKA_3; pfam07730 198215010761 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 198215010762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215010763 active site 198215010764 phosphorylation site [posttranslational modification] 198215010765 intermolecular recognition site; other site 198215010766 dimerization interface [polypeptide binding]; other site 198215010767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215010768 DNA binding residues [nucleotide binding] 198215010769 dimerization interface [polypeptide binding]; other site 198215010770 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 198215010771 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 198215010772 putative valine binding site [chemical binding]; other site 198215010773 dimer interface [polypeptide binding]; other site 198215010774 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 198215010775 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198215010776 PYR/PP interface [polypeptide binding]; other site 198215010777 dimer interface [polypeptide binding]; other site 198215010778 TPP binding site [chemical binding]; other site 198215010779 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198215010780 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198215010781 TPP-binding site [chemical binding]; other site 198215010782 dimer interface [polypeptide binding]; other site 198215010783 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 198215010784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010785 putative substrate translocation pore; other site 198215010786 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 198215010787 Domain of unknown function (DUF202); Region: DUF202; pfam02656 198215010788 Predicted membrane protein [Function unknown]; Region: COG2149 198215010789 putative transporter; Provisional; Region: PRK10484 198215010790 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 198215010791 Na binding site [ion binding]; other site 198215010792 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198215010793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215010794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198215010795 PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702 198215010796 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198215010797 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198215010798 active site turn [active] 198215010799 phosphorylation site [posttranslational modification] 198215010800 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198215010801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215010802 DNA-binding site [nucleotide binding]; DNA binding site 198215010803 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 198215010804 putative transporter; Validated; Region: PRK03818 198215010805 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 198215010806 TrkA-C domain; Region: TrkA_C; pfam02080 198215010807 TrkA-C domain; Region: TrkA_C; pfam02080 198215010808 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 198215010809 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198215010810 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 198215010811 putative dimer interface [polypeptide binding]; other site 198215010812 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198215010813 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 198215010814 putative dimer interface [polypeptide binding]; other site 198215010815 hypothetical protein; Provisional; Region: PRK11616 198215010816 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 198215010817 putative oxidoreductase; Provisional; Region: PRK11445 198215010818 hypothetical protein; Provisional; Region: PRK07236 198215010819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010820 D-galactonate transporter; Region: 2A0114; TIGR00893 198215010821 putative substrate translocation pore; other site 198215010822 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 198215010823 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 198215010824 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198215010825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215010826 DNA-binding site [nucleotide binding]; DNA binding site 198215010827 FCD domain; Region: FCD; pfam07729 198215010828 sugar phosphate phosphatase; Provisional; Region: PRK10513 198215010829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215010830 active site 198215010831 motif I; other site 198215010832 motif II; other site 198215010833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215010834 hypothetical protein; Provisional; Region: PRK11426 198215010835 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 198215010836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215010837 Mg2+ binding site [ion binding]; other site 198215010838 G-X-G motif; other site 198215010839 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198215010840 anchoring element; other site 198215010841 dimer interface [polypeptide binding]; other site 198215010842 ATP binding site [chemical binding]; other site 198215010843 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 198215010844 active site 198215010845 putative metal-binding site [ion binding]; other site 198215010846 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198215010847 recF protein; Region: recf; TIGR00611 198215010848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215010849 Walker A/P-loop; other site 198215010850 ATP binding site [chemical binding]; other site 198215010851 Q-loop/lid; other site 198215010852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215010853 ABC transporter signature motif; other site 198215010854 Walker B; other site 198215010855 D-loop; other site 198215010856 H-loop/switch region; other site 198215010857 DNA polymerase III subunit beta; Validated; Region: PRK05643 198215010858 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 198215010859 putative DNA binding surface [nucleotide binding]; other site 198215010860 dimer interface [polypeptide binding]; other site 198215010861 beta-clamp/clamp loader binding surface; other site 198215010862 beta-clamp/translesion DNA polymerase binding surface; other site 198215010863 DnaA N-terminal domain; Region: DnaA_N; pfam11638 198215010864 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 198215010865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215010866 Walker A motif; other site 198215010867 ATP binding site [chemical binding]; other site 198215010868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 198215010869 Walker B motif; other site 198215010870 arginine finger; other site 198215010871 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 198215010872 DnaA box-binding interface [nucleotide binding]; other site 198215010873 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 198215010874 ribonuclease P; Reviewed; Region: rnpA; PRK01732 198215010875 membrane protein insertase; Provisional; Region: PRK01318 198215010876 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 198215010877 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 198215010878 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 198215010879 trmE is a tRNA modification GTPase; Region: trmE; cd04164 198215010880 G1 box; other site 198215010881 GTP/Mg2+ binding site [chemical binding]; other site 198215010882 Switch I region; other site 198215010883 G2 box; other site 198215010884 Switch II region; other site 198215010885 G3 box; other site 198215010886 G4 box; other site 198215010887 G5 box; other site 198215010888 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 198215010889 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215010890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010891 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010892 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010893 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 198215010894 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 198215010895 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 198215010896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198215010897 catalytic residue [active] 198215010898 tryptophan permease TnaB; Provisional; Region: PRK09664 198215010899 aromatic amino acid transport protein; Region: araaP; TIGR00837 198215010900 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 198215010901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215010902 putative substrate translocation pore; other site 198215010903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215010904 Integrase core domain; Region: rve; pfam00665 198215010905 Integrase core domain; Region: rve_3; pfam13683 198215010906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215010907 Transposase; Region: HTH_Tnp_1; pfam01527 198215010908 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 198215010909 Predicted flavoprotein [General function prediction only]; Region: COG0431 198215010910 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198215010911 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198215010912 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 198215010913 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215010914 active site 198215010915 motif I; other site 198215010916 motif II; other site 198215010917 putative inner membrane protein; Provisional; Region: PRK09823 198215010918 Homeodomain-like domain; Region: HTH_23; pfam13384 198215010919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215010920 Transposase; Region: HTH_Tnp_1; pfam01527 198215010921 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215010922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215010923 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198215010924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215010925 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 198215010926 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215010927 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215010928 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 198215010929 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198215010930 active site 198215010931 trimer interface [polypeptide binding]; other site 198215010932 allosteric site; other site 198215010933 active site lid [active] 198215010934 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198215010935 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 198215010936 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 198215010937 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 198215010938 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 198215010939 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 198215010940 trimer interface; other site 198215010941 sugar binding site [chemical binding]; other site 198215010942 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215010943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010944 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010945 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010946 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 198215010947 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 198215010948 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198215010949 active site turn [active] 198215010950 phosphorylation site [posttranslational modification] 198215010951 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198215010952 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198215010953 HPr interaction site; other site 198215010954 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198215010955 active site 198215010956 phosphorylation site [posttranslational modification] 198215010957 transcriptional antiterminator BglG; Provisional; Region: PRK09772 198215010958 CAT RNA binding domain; Region: CAT_RBD; pfam03123 198215010959 PRD domain; Region: PRD; pfam00874 198215010960 PRD domain; Region: PRD; pfam00874 198215010961 transcriptional regulator PhoU; Provisional; Region: PRK11115 198215010962 PhoU domain; Region: PhoU; pfam01895 198215010963 PhoU domain; Region: PhoU; pfam01895 198215010964 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 198215010965 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 198215010966 Walker A/P-loop; other site 198215010967 ATP binding site [chemical binding]; other site 198215010968 Q-loop/lid; other site 198215010969 ABC transporter signature motif; other site 198215010970 Walker B; other site 198215010971 D-loop; other site 198215010972 H-loop/switch region; other site 198215010973 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 198215010974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215010975 dimer interface [polypeptide binding]; other site 198215010976 conserved gate region; other site 198215010977 putative PBP binding loops; other site 198215010978 ABC-ATPase subunit interface; other site 198215010979 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 198215010980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215010981 dimer interface [polypeptide binding]; other site 198215010982 conserved gate region; other site 198215010983 putative PBP binding loops; other site 198215010984 ABC-ATPase subunit interface; other site 198215010985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198215010986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215010987 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215010988 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215010989 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 198215010990 PapC N-terminal domain; Region: PapC_N; pfam13954 198215010991 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 198215010992 PapC C-terminal domain; Region: PapC_C; pfam13953 198215010993 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215010994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215010995 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215010996 HTH-like domain; Region: HTH_21; pfam13276 198215010997 Integrase core domain; Region: rve; pfam00665 198215010998 Integrase core domain; Region: rve_3; pfam13683 198215010999 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 198215011000 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198215011001 N-terminal plug; other site 198215011002 ligand-binding site [chemical binding]; other site 198215011003 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 198215011004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198215011005 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198215011006 IucA / IucC family; Region: IucA_IucC; pfam04183 198215011007 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198215011008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 198215011009 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 198215011010 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198215011011 IucA / IucC family; Region: IucA_IucC; pfam04183 198215011012 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198215011013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215011014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198215011015 putative substrate translocation pore; other site 198215011016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011017 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011018 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011019 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011020 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215011021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215011022 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215011023 HTH-like domain; Region: HTH_21; pfam13276 198215011024 Integrase core domain; Region: rve; pfam00665 198215011025 Integrase core domain; Region: rve_3; pfam13683 198215011026 Transposase; Region: HTH_Tnp_1; cl17663 198215011027 Integrase core domain; Region: rve; pfam00665 198215011028 Integrase core domain; Region: rve_3; pfam13683 198215011029 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 198215011030 putative transposase OrfB; Reviewed; Region: PHA02517 198215011031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 198215011032 TPR motif; other site 198215011033 binding surface 198215011034 integrase; Provisional; Region: PRK09692 198215011035 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198215011036 active site 198215011037 Int/Topo IB signature motif; other site 198215011038 putative alpha-glucosidase; Provisional; Region: PRK10658 198215011039 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 198215011040 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 198215011041 active site 198215011042 homotrimer interface [polypeptide binding]; other site 198215011043 catalytic site [active] 198215011044 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 198215011045 AsmA family; Region: AsmA; pfam05170 198215011046 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 198215011047 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198215011048 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 198215011049 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 198215011050 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 198215011051 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 198215011052 generic binding surface II; other site 198215011053 ssDNA binding site; other site 198215011054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198215011055 ATP binding site [chemical binding]; other site 198215011056 putative Mg++ binding site [ion binding]; other site 198215011057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198215011058 nucleotide binding region [chemical binding]; other site 198215011059 ATP-binding site [chemical binding]; other site 198215011060 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 198215011061 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198215011062 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 198215011063 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 198215011064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198215011065 Zn2+ binding site [ion binding]; other site 198215011066 Mg2+ binding site [ion binding]; other site 198215011067 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198215011068 synthetase active site [active] 198215011069 NTP binding site [chemical binding]; other site 198215011070 metal binding site [ion binding]; metal-binding site 198215011071 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 198215011072 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 198215011073 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 198215011074 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 198215011075 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 198215011076 catalytic site [active] 198215011077 G-X2-G-X-G-K; other site 198215011078 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 198215011079 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 198215011080 nucleotide binding pocket [chemical binding]; other site 198215011081 K-X-D-G motif; other site 198215011082 catalytic site [active] 198215011083 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 198215011084 Predicted membrane protein [Function unknown]; Region: COG2860 198215011085 UPF0126 domain; Region: UPF0126; pfam03458 198215011086 UPF0126 domain; Region: UPF0126; pfam03458 198215011087 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 198215011088 BRO family, N-terminal domain; Region: Bro-N; pfam02498 198215011089 hypothetical protein; Provisional; Region: PRK11820 198215011090 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 198215011091 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 198215011092 ribonuclease PH; Reviewed; Region: rph; PRK00173 198215011093 Ribonuclease PH; Region: RNase_PH_bact; cd11362 198215011094 hexamer interface [polypeptide binding]; other site 198215011095 active site 198215011096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215011097 active site 198215011098 division inhibitor protein; Provisional; Region: slmA; PRK09480 198215011099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215011100 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 198215011101 trimer interface [polypeptide binding]; other site 198215011102 active site 198215011103 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 198215011104 Flavoprotein; Region: Flavoprotein; pfam02441 198215011105 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 198215011106 hypothetical protein; Reviewed; Region: PRK00024 198215011107 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 198215011108 MPN+ (JAMM) motif; other site 198215011109 Zinc-binding site [ion binding]; other site 198215011110 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 198215011111 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 198215011112 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 198215011113 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 198215011114 DNA binding site [nucleotide binding] 198215011115 catalytic residue [active] 198215011116 H2TH interface [polypeptide binding]; other site 198215011117 putative catalytic residues [active] 198215011118 turnover-facilitating residue; other site 198215011119 intercalation triad [nucleotide binding]; other site 198215011120 8OG recognition residue [nucleotide binding]; other site 198215011121 putative reading head residues; other site 198215011122 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198215011123 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198215011124 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 198215011125 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 198215011126 active site 198215011127 (T/H)XGH motif; other site 198215011128 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 198215011129 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 198215011130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198215011131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011132 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011133 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011134 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011135 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 198215011136 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198215011137 putative active site [active] 198215011138 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198215011139 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198215011140 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 198215011141 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 198215011142 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 198215011143 Ligand binding site; other site 198215011144 metal-binding site 198215011145 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 198215011146 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 198215011147 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 198215011148 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 198215011149 Ligand binding site; other site 198215011150 metal-binding site 198215011151 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 198215011152 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 198215011153 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198215011154 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 198215011155 O-antigen ligase RfaL; Provisional; Region: PRK15487 198215011156 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198215011157 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 198215011158 putative active site [active] 198215011159 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 198215011160 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198215011161 putative active site [active] 198215011162 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 198215011163 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 198215011164 NADP binding site [chemical binding]; other site 198215011165 homopentamer interface [polypeptide binding]; other site 198215011166 substrate binding site [chemical binding]; other site 198215011167 active site 198215011168 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 198215011169 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 198215011170 substrate-cofactor binding pocket; other site 198215011171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215011172 catalytic residue [active] 198215011173 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 198215011174 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 198215011175 NAD(P) binding site [chemical binding]; other site 198215011176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011177 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011178 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011179 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011180 putative glycosyl transferase; Provisional; Region: PRK10073 198215011181 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 198215011182 putative active site [active] 198215011183 NodB motif; other site 198215011184 AmiB activator; Provisional; Region: PRK11637 198215011185 Peptidase family M23; Region: Peptidase_M23; pfam01551 198215011186 phosphoglyceromutase; Provisional; Region: PRK05434 198215011187 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 198215011188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198215011189 active site residue [active] 198215011190 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 198215011191 GSH binding site [chemical binding]; other site 198215011192 catalytic residues [active] 198215011193 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 198215011194 SecA binding site; other site 198215011195 Preprotein binding site; other site 198215011196 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 198215011197 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 198215011198 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 198215011199 serine acetyltransferase; Provisional; Region: cysE; PRK11132 198215011200 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 198215011201 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 198215011202 trimer interface [polypeptide binding]; other site 198215011203 active site 198215011204 substrate binding site [chemical binding]; other site 198215011205 CoA binding site [chemical binding]; other site 198215011206 putative rRNA methylase; Provisional; Region: PRK10358 198215011207 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 198215011208 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 198215011209 phosphate binding site [ion binding]; other site 198215011210 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 198215011211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215011212 DNA-binding site [nucleotide binding]; DNA binding site 198215011213 FCD domain; Region: FCD; pfam07729 198215011214 L-lactate permease; Provisional; Region: PRK10420 198215011215 glycolate transporter; Provisional; Region: PRK09695 198215011216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011217 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011218 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011219 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011220 hypothetical protein; Provisional; Region: PRK11020 198215011221 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 198215011222 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 198215011223 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 198215011224 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198215011225 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198215011226 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 198215011227 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 198215011228 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 198215011229 active site 198215011230 P-loop; other site 198215011231 phosphorylation site [posttranslational modification] 198215011232 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215011233 active site 198215011234 phosphorylation site [posttranslational modification] 198215011235 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 198215011236 HlyD family secretion protein; Region: HlyD; pfam00529 198215011237 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215011238 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215011239 putative glutathione S-transferase; Provisional; Region: PRK10357 198215011240 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 198215011241 putative C-terminal domain interface [polypeptide binding]; other site 198215011242 putative GSH binding site (G-site) [chemical binding]; other site 198215011243 putative dimer interface [polypeptide binding]; other site 198215011244 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 198215011245 dimer interface [polypeptide binding]; other site 198215011246 N-terminal domain interface [polypeptide binding]; other site 198215011247 putative substrate binding pocket (H-site) [chemical binding]; other site 198215011248 selenocysteine synthase; Provisional; Region: PRK04311 198215011249 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 198215011250 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 198215011251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198215011252 catalytic residue [active] 198215011253 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 198215011254 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 198215011255 G1 box; other site 198215011256 putative GEF interaction site [polypeptide binding]; other site 198215011257 GTP/Mg2+ binding site [chemical binding]; other site 198215011258 Switch I region; other site 198215011259 G2 box; other site 198215011260 G3 box; other site 198215011261 Switch II region; other site 198215011262 G4 box; other site 198215011263 G5 box; other site 198215011264 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 198215011265 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 198215011266 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 198215011267 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 198215011268 putative alcohol dehydrogenase; Provisional; Region: PRK09860 198215011269 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 198215011270 dimer interface [polypeptide binding]; other site 198215011271 active site 198215011272 metal binding site [ion binding]; metal-binding site 198215011273 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 198215011274 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 198215011275 NAD(P) binding site [chemical binding]; other site 198215011276 catalytic residues [active] 198215011277 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011279 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011280 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011281 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 198215011282 DctM-like transporters; Region: DctM; pfam06808 198215011283 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011285 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011286 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011287 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 198215011288 Transcriptional regulator [Transcription]; Region: IclR; COG1414 198215011289 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198215011290 Bacterial transcriptional regulator; Region: IclR; pfam01614 198215011291 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198215011292 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 198215011293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198215011294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215011295 homodimer interface [polypeptide binding]; other site 198215011296 catalytic residue [active] 198215011297 alpha-amylase; Reviewed; Region: malS; PRK09505 198215011298 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 198215011299 active site 198215011300 catalytic site [active] 198215011301 hypothetical protein; Provisional; Region: PRK10356 198215011302 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 198215011303 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215011304 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215011305 TM-ABC transporter signature motif; other site 198215011306 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 198215011307 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198215011308 Walker A/P-loop; other site 198215011309 ATP binding site [chemical binding]; other site 198215011310 Q-loop/lid; other site 198215011311 ABC transporter signature motif; other site 198215011312 Walker B; other site 198215011313 D-loop; other site 198215011314 H-loop/switch region; other site 198215011315 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198215011316 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 198215011317 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 198215011318 putative ligand binding site [chemical binding]; other site 198215011319 xylulokinase; Provisional; Region: PRK15027 198215011320 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 198215011321 N- and C-terminal domain interface [polypeptide binding]; other site 198215011322 active site 198215011323 MgATP binding site [chemical binding]; other site 198215011324 catalytic site [active] 198215011325 metal binding site [ion binding]; metal-binding site 198215011326 xylulose binding site [chemical binding]; other site 198215011327 homodimer interface [polypeptide binding]; other site 198215011328 hypothetical protein; Provisional; Region: PRK11403 198215011329 yiaA/B two helix domain; Region: YiaAB; pfam05360 198215011330 hypothetical protein; Provisional; Region: PRK11383 198215011331 yiaA/B two helix domain; Region: YiaAB; pfam05360 198215011332 yiaA/B two helix domain; Region: YiaAB; pfam05360 198215011333 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 198215011334 Acyltransferase family; Region: Acyl_transf_3; pfam01757 198215011335 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 198215011336 dimer interface [polypeptide binding]; other site 198215011337 motif 1; other site 198215011338 active site 198215011339 motif 2; other site 198215011340 motif 3; other site 198215011341 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 198215011342 DALR anticodon binding domain; Region: DALR_1; pfam05746 198215011343 anticodon binding site; other site 198215011344 tRNA binding surface [nucleotide binding]; other site 198215011345 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011347 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011348 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011349 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 198215011350 transcriptional regulator YdeO; Provisional; Region: PRK09940 198215011351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215011352 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 198215011353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215011354 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 198215011355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215011356 catalytic residue [active] 198215011357 Haem-binding domain; Region: Haem_bd; pfam14376 198215011358 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 198215011359 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011361 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011362 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011363 putative transposase OrfB; Reviewed; Region: PHA02517 198215011364 HTH-like domain; Region: HTH_21; pfam13276 198215011365 Integrase core domain; Region: rve; pfam00665 198215011366 Integrase core domain; Region: rve_2; pfam13333 198215011367 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198215011368 DNA-binding site [nucleotide binding]; DNA binding site 198215011369 RNA-binding motif; other site 198215011370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 198215011371 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 198215011372 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 198215011373 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 198215011374 dimerization interface [polypeptide binding]; other site 198215011375 ligand binding site [chemical binding]; other site 198215011376 NADP binding site [chemical binding]; other site 198215011377 catalytic site [active] 198215011378 putative outer membrane lipoprotein; Provisional; Region: PRK10510 198215011379 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198215011380 ligand binding site [chemical binding]; other site 198215011381 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 198215011382 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 198215011383 molybdopterin cofactor binding site [chemical binding]; other site 198215011384 substrate binding site [chemical binding]; other site 198215011385 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 198215011386 molybdopterin cofactor binding site; other site 198215011387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198215011388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215011389 Coenzyme A binding pocket [chemical binding]; other site 198215011390 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 198215011391 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 198215011392 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 198215011393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215011394 putative substrate translocation pore; other site 198215011395 phosphoethanolamine transferase; Provisional; Region: PRK11560 198215011396 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198215011397 Sulfatase; Region: Sulfatase; pfam00884 198215011398 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198215011399 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 198215011400 peptide binding site [polypeptide binding]; other site 198215011401 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198215011402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215011403 dimer interface [polypeptide binding]; other site 198215011404 conserved gate region; other site 198215011405 putative PBP binding loops; other site 198215011406 ABC-ATPase subunit interface; other site 198215011407 dipeptide transporter; Provisional; Region: PRK10913 198215011408 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198215011409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215011410 dimer interface [polypeptide binding]; other site 198215011411 conserved gate region; other site 198215011412 putative PBP binding loops; other site 198215011413 ABC-ATPase subunit interface; other site 198215011414 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 198215011415 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215011416 Walker A/P-loop; other site 198215011417 ATP binding site [chemical binding]; other site 198215011418 Q-loop/lid; other site 198215011419 ABC transporter signature motif; other site 198215011420 Walker B; other site 198215011421 D-loop; other site 198215011422 H-loop/switch region; other site 198215011423 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198215011424 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 198215011425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215011426 Walker A/P-loop; other site 198215011427 ATP binding site [chemical binding]; other site 198215011428 Q-loop/lid; other site 198215011429 ABC transporter signature motif; other site 198215011430 Walker B; other site 198215011431 D-loop; other site 198215011432 H-loop/switch region; other site 198215011433 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198215011434 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198215011435 serine transporter; Region: stp; TIGR00814 198215011436 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 198215011437 Protein of unknown function (DUF2636); Region: DUF2636; cl11897 198215011438 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 198215011439 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 198215011440 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 198215011441 cell division protein; Provisional; Region: PRK10037 198215011442 cellulose synthase regulator protein; Provisional; Region: PRK11114 198215011443 endo-1,4-D-glucanase; Provisional; Region: PRK11097 198215011444 putative diguanylate cyclase; Provisional; Region: PRK13561 198215011445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198215011446 metal binding site [ion binding]; metal-binding site 198215011447 active site 198215011448 I-site; other site 198215011449 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198215011450 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 198215011451 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198215011452 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198215011453 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198215011454 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215011455 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198215011456 substrate binding site [chemical binding]; other site 198215011457 ATP binding site [chemical binding]; other site 198215011458 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198215011459 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 198215011460 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198215011461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215011462 metabolite-proton symporter; Region: 2A0106; TIGR00883 198215011463 putative substrate translocation pore; other site 198215011464 inner membrane protein YhjD; Region: TIGR00766 198215011465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198215011466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215011467 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 198215011468 putative effector binding pocket; other site 198215011469 putative dimerization interface [polypeptide binding]; other site 198215011470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198215011471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215011472 DNA binding residues [nucleotide binding] 198215011473 dimerization interface [polypeptide binding]; other site 198215011474 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215011475 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215011476 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215011477 trehalase; Provisional; Region: treF; PRK13270 198215011478 Trehalase; Region: Trehalase; pfam01204 198215011479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011480 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011481 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011482 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011483 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198215011484 pyruvate kinase; Provisional; Region: PRK05826 198215011485 acid-resistance membrane protein; Provisional; Region: PRK10209 198215011486 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 198215011487 acid-resistance protein; Provisional; Region: PRK10208 198215011488 acid-resistance protein; Provisional; Region: hdeB; PRK11566 198215011489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198215011490 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215011491 DNA binding residues [nucleotide binding] 198215011492 dimerization interface [polypeptide binding]; other site 198215011493 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 198215011494 Predicted permeases [General function prediction only]; Region: COG0701 198215011495 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011497 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011498 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198215011500 dimerization interface [polypeptide binding]; other site 198215011501 putative DNA binding site [nucleotide binding]; other site 198215011502 putative Zn2+ binding site [ion binding]; other site 198215011503 arsenical pump membrane protein; Provisional; Region: PRK15445 198215011504 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 198215011505 transmembrane helices; other site 198215011506 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 198215011507 ArsC family; Region: ArsC; pfam03960 198215011508 catalytic residues [active] 198215011509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011510 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011511 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011512 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011513 glutathione reductase; Validated; Region: PRK06116 198215011514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198215011515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215011516 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 198215011517 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 198215011518 oligopeptidase A; Provisional; Region: PRK10911 198215011519 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 198215011520 active site 198215011521 Zn binding site [ion binding]; other site 198215011522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215011523 S-adenosylmethionine binding site [chemical binding]; other site 198215011524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198215011525 Ligand Binding Site [chemical binding]; other site 198215011526 universal stress protein UspB; Provisional; Region: PRK04960 198215011527 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198215011528 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198215011529 Predicted flavoproteins [General function prediction only]; Region: COG2081 198215011530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215011531 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215011532 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215011533 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215011534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215011535 Transposase; Region: HTH_Tnp_1; pfam01527 198215011536 O-Antigen ligase; Region: Wzy_C; pfam04932 198215011537 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 198215011538 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 198215011539 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 198215011540 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 198215011541 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 198215011542 PapC N-terminal domain; Region: PapC_N; pfam13954 198215011543 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 198215011544 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215011545 HTH-like domain; Region: HTH_21; pfam13276 198215011546 Integrase core domain; Region: rve; pfam00665 198215011547 Integrase core domain; Region: rve_3; pfam13683 198215011548 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215011549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215011550 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198215011551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215011552 DNA binding residues [nucleotide binding] 198215011553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 198215011554 DNA binding site [nucleotide binding] 198215011555 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 198215011556 HlyD family secretion protein; Region: HlyD; pfam00529 198215011557 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198215011558 HlyD family secretion protein; Region: HlyD_3; pfam13437 198215011559 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198215011560 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198215011561 Walker A/P-loop; other site 198215011562 ATP binding site [chemical binding]; other site 198215011563 Q-loop/lid; other site 198215011564 ABC transporter signature motif; other site 198215011565 Walker B; other site 198215011566 D-loop; other site 198215011567 H-loop/switch region; other site 198215011568 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198215011569 Walker A/P-loop; other site 198215011570 ATP binding site [chemical binding]; other site 198215011571 Q-loop/lid; other site 198215011572 ABC transporter signature motif; other site 198215011573 Walker B; other site 198215011574 D-loop; other site 198215011575 H-loop/switch region; other site 198215011576 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198215011577 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 198215011578 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198215011579 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198215011580 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 198215011581 HicB family; Region: HicB; pfam05534 198215011582 nickel responsive regulator; Provisional; Region: PRK02967 198215011583 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 198215011584 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 198215011585 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215011586 Walker A/P-loop; other site 198215011587 ATP binding site [chemical binding]; other site 198215011588 Q-loop/lid; other site 198215011589 ABC transporter signature motif; other site 198215011590 Walker B; other site 198215011591 D-loop; other site 198215011592 H-loop/switch region; other site 198215011593 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 198215011594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198215011595 Walker A/P-loop; other site 198215011596 ATP binding site [chemical binding]; other site 198215011597 Q-loop/lid; other site 198215011598 ABC transporter signature motif; other site 198215011599 Walker B; other site 198215011600 D-loop; other site 198215011601 H-loop/switch region; other site 198215011602 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198215011603 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 198215011604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215011605 dimer interface [polypeptide binding]; other site 198215011606 conserved gate region; other site 198215011607 putative PBP binding loops; other site 198215011608 ABC-ATPase subunit interface; other site 198215011609 nickel transporter permease NikB; Provisional; Region: PRK10352 198215011610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215011611 dimer interface [polypeptide binding]; other site 198215011612 conserved gate region; other site 198215011613 putative PBP binding loops; other site 198215011614 ABC-ATPase subunit interface; other site 198215011615 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198215011616 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 198215011617 substrate binding site [chemical binding]; other site 198215011618 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 198215011619 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 198215011620 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 198215011621 Domain of unknown function DUF20; Region: UPF0118; pfam01594 198215011622 major facilitator superfamily transporter; Provisional; Region: PRK05122 198215011623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215011624 putative substrate translocation pore; other site 198215011625 hypothetical protein; Provisional; Region: PRK11615 198215011626 hypothetical protein; Provisional; Region: PRK11212 198215011627 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 198215011628 CPxP motif; other site 198215011629 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 198215011630 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198215011631 metal-binding site [ion binding] 198215011632 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198215011633 Predicted membrane protein [Function unknown]; Region: COG3714 198215011634 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 198215011635 hypothetical protein; Provisional; Region: PRK10910 198215011636 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 198215011637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215011638 S-adenosylmethionine binding site [chemical binding]; other site 198215011639 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 198215011640 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 198215011641 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198215011642 P loop; other site 198215011643 GTP binding site [chemical binding]; other site 198215011644 cell division protein FtsE; Provisional; Region: PRK10908 198215011645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215011646 Walker A/P-loop; other site 198215011647 ATP binding site [chemical binding]; other site 198215011648 Q-loop/lid; other site 198215011649 ABC transporter signature motif; other site 198215011650 Walker B; other site 198215011651 D-loop; other site 198215011652 H-loop/switch region; other site 198215011653 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 198215011654 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 198215011655 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 198215011656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198215011657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198215011658 DNA binding residues [nucleotide binding] 198215011659 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 198215011660 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 198215011661 dimerization interface [polypeptide binding]; other site 198215011662 ligand binding site [chemical binding]; other site 198215011663 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 198215011664 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 198215011665 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 198215011666 dimerization interface [polypeptide binding]; other site 198215011667 ligand binding site [chemical binding]; other site 198215011668 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215011669 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 198215011670 TM-ABC transporter signature motif; other site 198215011671 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 198215011672 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 198215011673 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 198215011674 TM-ABC transporter signature motif; other site 198215011675 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 198215011676 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 198215011677 Walker A/P-loop; other site 198215011678 ATP binding site [chemical binding]; other site 198215011679 Q-loop/lid; other site 198215011680 ABC transporter signature motif; other site 198215011681 Walker B; other site 198215011682 D-loop; other site 198215011683 H-loop/switch region; other site 198215011684 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 198215011685 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 198215011686 Walker A/P-loop; other site 198215011687 ATP binding site [chemical binding]; other site 198215011688 Q-loop/lid; other site 198215011689 ABC transporter signature motif; other site 198215011690 Walker B; other site 198215011691 D-loop; other site 198215011692 H-loop/switch region; other site 198215011693 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 198215011694 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198215011695 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198215011696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215011697 dimer interface [polypeptide binding]; other site 198215011698 conserved gate region; other site 198215011699 putative PBP binding loops; other site 198215011700 ABC-ATPase subunit interface; other site 198215011701 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198215011702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198215011703 dimer interface [polypeptide binding]; other site 198215011704 conserved gate region; other site 198215011705 putative PBP binding loops; other site 198215011706 ABC-ATPase subunit interface; other site 198215011707 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 198215011708 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 198215011709 putative active site [active] 198215011710 catalytic site [active] 198215011711 putative metal binding site [ion binding]; other site 198215011712 hypothetical protein; Provisional; Region: PRK10350 198215011713 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 198215011714 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 198215011715 putative acetyltransferase YhhY; Provisional; Region: PRK10140 198215011716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215011717 Coenzyme A binding pocket [chemical binding]; other site 198215011718 putative oxidoreductase; Provisional; Region: PRK10206 198215011719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198215011720 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198215011721 Pirin-related protein [General function prediction only]; Region: COG1741 198215011722 Pirin; Region: Pirin; pfam02678 198215011723 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 198215011724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215011725 DNA binding site [nucleotide binding] 198215011726 domain linker motif; other site 198215011727 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 198215011728 putative ligand binding site [chemical binding]; other site 198215011729 putative dimerization interface [polypeptide binding]; other site 198215011730 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 198215011731 ATP-binding site [chemical binding]; other site 198215011732 Gluconate-6-phosphate binding site [chemical binding]; other site 198215011733 Shikimate kinase; Region: SKI; pfam01202 198215011734 low affinity gluconate transporter; Provisional; Region: PRK10472 198215011735 gluconate transporter; Region: gntP; TIGR00791 198215011736 putative antibiotic transporter; Provisional; Region: PRK10739 198215011737 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 198215011738 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 198215011739 glycogen branching enzyme; Provisional; Region: PRK05402 198215011740 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 198215011741 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 198215011742 active site 198215011743 catalytic site [active] 198215011744 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 198215011745 glycogen debranching enzyme; Provisional; Region: PRK03705 198215011746 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 198215011747 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 198215011748 active site 198215011749 catalytic site [active] 198215011750 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 198215011751 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 198215011752 ligand binding site; other site 198215011753 oligomer interface; other site 198215011754 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 198215011755 sulfate 1 binding site; other site 198215011756 glycogen synthase; Provisional; Region: glgA; PRK00654 198215011757 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 198215011758 ADP-binding pocket [chemical binding]; other site 198215011759 homodimer interface [polypeptide binding]; other site 198215011760 glycogen phosphorylase; Provisional; Region: PRK14986 198215011761 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 198215011762 homodimer interface [polypeptide binding]; other site 198215011763 active site pocket [active] 198215011764 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215011765 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215011766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215011767 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215011768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215011769 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 198215011770 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 198215011771 active site residue [active] 198215011772 intramembrane serine protease GlpG; Provisional; Region: PRK10907 198215011773 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 198215011774 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 198215011775 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 198215011776 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198215011777 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215011778 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 198215011779 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 198215011780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215011781 Walker A motif; other site 198215011782 ATP binding site [chemical binding]; other site 198215011783 Walker B motif; other site 198215011784 arginine finger; other site 198215011785 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 198215011786 hypothetical protein; Reviewed; Region: PRK09588 198215011787 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 198215011788 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 198215011789 putative active site [active] 198215011790 maltodextrin phosphorylase; Provisional; Region: PRK14985 198215011791 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 198215011792 active site pocket [active] 198215011793 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 198215011794 4-alpha-glucanotransferase; Region: malQ; TIGR00217 198215011795 high-affinity gluconate transporter; Provisional; Region: PRK14984 198215011796 gluconate transporter; Region: gntP; TIGR00791 198215011797 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 198215011798 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 198215011799 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 198215011800 DNA utilization protein GntX; Provisional; Region: PRK11595 198215011801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198215011802 active site 198215011803 carboxylesterase BioH; Provisional; Region: PRK10349 198215011804 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 198215011805 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215011806 HTH-like domain; Region: HTH_21; pfam13276 198215011807 Integrase core domain; Region: rve; pfam00665 198215011808 Integrase core domain; Region: rve_3; pfam13683 198215011809 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215011810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215011811 putative transposase; Provisional; Region: PRK09857 198215011812 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198215011813 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 198215011814 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 198215011815 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 198215011816 G1 box; other site 198215011817 GTP/Mg2+ binding site [chemical binding]; other site 198215011818 Switch I region; other site 198215011819 G2 box; other site 198215011820 G3 box; other site 198215011821 Switch II region; other site 198215011822 G4 box; other site 198215011823 G5 box; other site 198215011824 Nucleoside recognition; Region: Gate; pfam07670 198215011825 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 198215011826 Nucleoside recognition; Region: Gate; pfam07670 198215011827 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 198215011828 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 198215011829 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 198215011830 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 198215011831 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 198215011832 RNA binding site [nucleotide binding]; other site 198215011833 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 198215011834 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 198215011835 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198215011836 osmolarity response regulator; Provisional; Region: ompR; PRK09468 198215011837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215011838 active site 198215011839 phosphorylation site [posttranslational modification] 198215011840 intermolecular recognition site; other site 198215011841 dimerization interface [polypeptide binding]; other site 198215011842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215011843 DNA binding site [nucleotide binding] 198215011844 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 198215011845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215011846 dimerization interface [polypeptide binding]; other site 198215011847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215011848 dimer interface [polypeptide binding]; other site 198215011849 phosphorylation site [posttranslational modification] 198215011850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215011851 ATP binding site [chemical binding]; other site 198215011852 G-X-G motif; other site 198215011853 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 198215011854 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 198215011855 active site 198215011856 substrate-binding site [chemical binding]; other site 198215011857 metal-binding site [ion binding] 198215011858 ATP binding site [chemical binding]; other site 198215011859 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 198215011860 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 198215011861 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 198215011862 dimerization interface [polypeptide binding]; other site 198215011863 domain crossover interface; other site 198215011864 redox-dependent activation switch; other site 198215011865 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215011866 RNA binding surface [nucleotide binding]; other site 198215011867 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 198215011868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215011869 motif II; other site 198215011870 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 198215011871 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 198215011872 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198215011873 ADP-ribose binding site [chemical binding]; other site 198215011874 dimer interface [polypeptide binding]; other site 198215011875 active site 198215011876 nudix motif; other site 198215011877 metal binding site [ion binding]; metal-binding site 198215011878 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 198215011879 Transglycosylase; Region: Transgly; pfam00912 198215011880 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198215011881 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 198215011882 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 198215011883 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 198215011884 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198215011885 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 198215011886 shikimate kinase; Reviewed; Region: aroK; PRK00131 198215011887 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 198215011888 ADP binding site [chemical binding]; other site 198215011889 magnesium binding site [ion binding]; other site 198215011890 putative shikimate binding site; other site 198215011891 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 198215011892 active site 198215011893 dimer interface [polypeptide binding]; other site 198215011894 metal binding site [ion binding]; metal-binding site 198215011895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 198215011896 cell division protein DamX; Validated; Region: PRK10905 198215011897 DNA adenine methylase; Provisional; Region: PRK10904 198215011898 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 198215011899 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 198215011900 substrate binding site [chemical binding]; other site 198215011901 hexamer interface [polypeptide binding]; other site 198215011902 metal binding site [ion binding]; metal-binding site 198215011903 phosphoglycolate phosphatase; Provisional; Region: PRK13222 198215011904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215011905 motif II; other site 198215011906 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 198215011907 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 198215011908 active site 198215011909 HIGH motif; other site 198215011910 dimer interface [polypeptide binding]; other site 198215011911 KMSKS motif; other site 198215011912 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 198215011913 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 198215011914 dimer interface [polypeptide binding]; other site 198215011915 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 198215011916 active site 198215011917 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198215011918 substrate binding site [chemical binding]; other site 198215011919 catalytic residue [active] 198215011920 putative mutase; Provisional; Region: PRK12383 198215011921 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 198215011922 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 198215011923 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 198215011924 active site 198215011925 substrate binding pocket [chemical binding]; other site 198215011926 homodimer interaction site [polypeptide binding]; other site 198215011927 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 198215011928 Protein of unknown function; Region: YhfT; pfam10797 198215011929 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 198215011930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215011931 DNA-binding site [nucleotide binding]; DNA binding site 198215011932 UTRA domain; Region: UTRA; pfam07702 198215011933 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 198215011934 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198215011935 substrate binding site [chemical binding]; other site 198215011936 ATP binding site [chemical binding]; other site 198215011937 fructoselysine 3-epimerase; Provisional; Region: PRK09856 198215011938 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 198215011939 DNA interaction; other site 198215011940 Metal-binding active site; metal-binding site 198215011941 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 198215011942 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 198215011943 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 198215011944 dimer interface [polypeptide binding]; other site 198215011945 active site 198215011946 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 198215011947 siroheme synthase; Provisional; Region: cysG; PRK10637 198215011948 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 198215011949 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 198215011950 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 198215011951 active site 198215011952 SAM binding site [chemical binding]; other site 198215011953 homodimer interface [polypeptide binding]; other site 198215011954 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 198215011955 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 198215011956 nitrite reductase subunit NirD; Provisional; Region: PRK14989 198215011957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198215011958 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198215011959 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198215011960 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198215011961 putative transporter; Provisional; Region: PRK03699 198215011962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215011963 putative substrate translocation pore; other site 198215011964 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 198215011965 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 198215011966 substrate binding site [chemical binding]; other site 198215011967 hypothetical protein; Provisional; Region: PRK10204 198215011968 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 198215011969 cell filamentation protein Fic; Provisional; Region: PRK10347 198215011970 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 198215011971 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198215011972 glutamine binding [chemical binding]; other site 198215011973 catalytic triad [active] 198215011974 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 198215011975 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198215011976 inhibitor-cofactor binding pocket; inhibition site 198215011977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198215011978 catalytic residue [active] 198215011979 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 198215011980 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 198215011981 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198215011982 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 198215011983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198215011984 ligand binding site [chemical binding]; other site 198215011985 flexible hinge region; other site 198215011986 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 198215011987 putative switch regulator; other site 198215011988 non-specific DNA interactions [nucleotide binding]; other site 198215011989 DNA binding site [nucleotide binding] 198215011990 sequence specific DNA binding site [nucleotide binding]; other site 198215011991 putative cAMP binding site [chemical binding]; other site 198215011992 hypothetical protein; Provisional; Region: PRK10738 198215011993 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 198215011994 active site 198215011995 hypothetical protein; Provisional; Region: PRK04966 198215011996 putative hydrolase; Provisional; Region: PRK10985 198215011997 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 198215011998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215011999 Walker A/P-loop; other site 198215012000 ATP binding site [chemical binding]; other site 198215012001 Q-loop/lid; other site 198215012002 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198215012003 ABC transporter; Region: ABC_tran_2; pfam12848 198215012004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198215012005 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 198215012006 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 198215012007 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 198215012008 TrkA-N domain; Region: TrkA_N; pfam02254 198215012009 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 198215012010 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198215012011 phi X174 lysis protein; Provisional; Region: PRK02793 198215012012 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 198215012013 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 198215012014 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198215012015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 198215012016 YheO-like PAS domain; Region: PAS_6; pfam08348 198215012017 HTH domain; Region: HTH_22; pfam13309 198215012018 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 198215012019 sulfur relay protein TusC; Validated; Region: PRK00211 198215012020 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 198215012021 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 198215012022 S17 interaction site [polypeptide binding]; other site 198215012023 S8 interaction site; other site 198215012024 16S rRNA interaction site [nucleotide binding]; other site 198215012025 streptomycin interaction site [chemical binding]; other site 198215012026 23S rRNA interaction site [nucleotide binding]; other site 198215012027 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 198215012028 30S ribosomal protein S7; Validated; Region: PRK05302 198215012029 elongation factor G; Reviewed; Region: PRK00007 198215012030 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 198215012031 Switch I region; other site 198215012032 G2 box; other site 198215012033 putative GEF interaction site [polypeptide binding]; other site 198215012034 G3 box; other site 198215012035 Switch II region; other site 198215012036 GTP/Mg2+ binding site [chemical binding]; other site 198215012037 G4 box; other site 198215012038 G5 box; other site 198215012039 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 198215012040 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 198215012041 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 198215012042 elongation factor Tu; Reviewed; Region: PRK00049 198215012043 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 198215012044 G1 box; other site 198215012045 GEF interaction site [polypeptide binding]; other site 198215012046 GTP/Mg2+ binding site [chemical binding]; other site 198215012047 Switch I region; other site 198215012048 G2 box; other site 198215012049 G3 box; other site 198215012050 Switch II region; other site 198215012051 G4 box; other site 198215012052 G5 box; other site 198215012053 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 198215012054 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 198215012055 Antibiotic Binding Site [chemical binding]; other site 198215012056 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 198215012057 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 198215012058 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 198215012059 heme binding site [chemical binding]; other site 198215012060 ferroxidase pore; other site 198215012061 ferroxidase diiron center [ion binding]; other site 198215012062 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 198215012063 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 198215012064 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 198215012065 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 198215012066 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 198215012067 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 198215012068 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 198215012069 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 198215012070 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 198215012071 protein-rRNA interface [nucleotide binding]; other site 198215012072 putative translocon binding site; other site 198215012073 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 198215012074 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 198215012075 G-X-X-G motif; other site 198215012076 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 198215012077 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 198215012078 23S rRNA interface [nucleotide binding]; other site 198215012079 5S rRNA interface [nucleotide binding]; other site 198215012080 putative antibiotic binding site [chemical binding]; other site 198215012081 L25 interface [polypeptide binding]; other site 198215012082 L27 interface [polypeptide binding]; other site 198215012083 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 198215012084 23S rRNA interface [nucleotide binding]; other site 198215012085 putative translocon interaction site; other site 198215012086 signal recognition particle (SRP54) interaction site; other site 198215012087 L23 interface [polypeptide binding]; other site 198215012088 trigger factor interaction site; other site 198215012089 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 198215012090 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 198215012091 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 198215012092 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 198215012093 RNA binding site [nucleotide binding]; other site 198215012094 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 198215012095 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 198215012096 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 198215012097 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 198215012098 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 198215012099 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 198215012100 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198215012101 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198215012102 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 198215012103 23S rRNA interface [nucleotide binding]; other site 198215012104 5S rRNA interface [nucleotide binding]; other site 198215012105 L27 interface [polypeptide binding]; other site 198215012106 L5 interface [polypeptide binding]; other site 198215012107 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 198215012108 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 198215012109 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 198215012110 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 198215012111 23S rRNA binding site [nucleotide binding]; other site 198215012112 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 198215012113 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 198215012114 SecY translocase; Region: SecY; pfam00344 198215012115 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 198215012116 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 198215012117 30S ribosomal protein S13; Region: bact_S13; TIGR03631 198215012118 30S ribosomal protein S11; Validated; Region: PRK05309 198215012119 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 198215012120 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 198215012121 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198215012122 RNA binding surface [nucleotide binding]; other site 198215012123 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 198215012124 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 198215012125 alphaNTD homodimer interface [polypeptide binding]; other site 198215012126 alphaNTD - beta interaction site [polypeptide binding]; other site 198215012127 alphaNTD - beta' interaction site [polypeptide binding]; other site 198215012128 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 198215012129 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 198215012130 Homeodomain-like domain; Region: HTH_23; pfam13384 198215012131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215012132 Transposase; Region: HTH_Tnp_1; pfam01527 198215012133 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198215012134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215012135 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198215012136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215012137 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 198215012138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198215012139 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198215012140 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198215012141 IS2 repressor TnpA; Reviewed; Region: PRK09413 198215012142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215012143 IS2 transposase TnpB; Reviewed; Region: PRK09409 198215012144 HTH-like domain; Region: HTH_21; pfam13276 198215012145 Integrase core domain; Region: rve; pfam00665 198215012146 Integrase core domain; Region: rve_3; pfam13683 198215012147 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 198215012148 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 198215012149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 198215012150 Nucleoside recognition; Region: Gate; pfam07670 198215012151 hypothetical protein; Provisional; Region: PRK10519 198215012152 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 198215012153 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 198215012154 dimer interface [polypeptide binding]; other site 198215012155 active site 198215012156 cell density-dependent motility repressor; Provisional; Region: PRK10082 198215012157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198215012158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198215012159 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 198215012160 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012162 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012163 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012164 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 198215012165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198215012166 DNA-binding site [nucleotide binding]; DNA binding site 198215012167 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198215012168 D-mannonate oxidoreductase; Provisional; Region: PRK15037 198215012169 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198215012170 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198215012171 mannonate dehydratase; Region: uxuA; TIGR00695 198215012172 mannonate dehydratase; Provisional; Region: PRK03906 198215012173 fructuronate transporter; Provisional; Region: PRK10034 198215012174 gluconate transporter; Region: gntP; TIGR00791 198215012175 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 198215012176 mannosyl binding site [chemical binding]; other site 198215012177 Fimbrial protein; Region: Fimbrial; pfam00419 198215012178 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198215012179 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198215012180 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012182 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012183 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012184 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 198215012185 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 198215012186 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 198215012187 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198215012188 Fimbrial protein; Region: Fimbrial; cl01416 198215012189 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 198215012190 Int/Topo IB signature motif; other site 198215012191 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198215012192 active site 198215012193 Int/Topo IB signature motif; other site 198215012194 DNA binding site [nucleotide binding] 198215012195 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 198215012196 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 198215012197 Kelch motif; Region: Kelch_1; pfam01344 198215012198 Domain of unknown function (DUF303); Region: DUF303; pfam03629 198215012199 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012201 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012202 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012203 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215012204 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 198215012205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215012206 Transposase; Region: HTH_Tnp_1; pfam01527 198215012207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215012208 Transposase; Region: HTH_Tnp_1; pfam01527 198215012209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215012210 Integrase core domain; Region: rve; pfam00665 198215012211 Integrase core domain; Region: rve_3; pfam13683 198215012212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012213 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012214 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012215 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215012217 Transposase; Region: HTH_Tnp_1; pfam01527 198215012218 Integrase core domain; Region: rve; pfam00665 198215012219 Integrase core domain; Region: rve_3; pfam13683 198215012220 integrase; Provisional; Region: PRK09692 198215012221 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198215012222 active site 198215012223 Int/Topo IB signature motif; other site 198215012224 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 198215012225 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 198215012226 putative NAD(P) binding site [chemical binding]; other site 198215012227 putative substrate binding site [chemical binding]; other site 198215012228 catalytic Zn binding site [ion binding]; other site 198215012229 structural Zn binding site [ion binding]; other site 198215012230 dimer interface [polypeptide binding]; other site 198215012231 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 198215012232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 198215012233 Walker A motif; other site 198215012234 ATP binding site [chemical binding]; other site 198215012235 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 198215012236 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198215012237 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 198215012238 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198215012239 multifunctional aminopeptidase A; Provisional; Region: PRK00913 198215012240 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 198215012241 interface (dimer of trimers) [polypeptide binding]; other site 198215012242 Substrate-binding/catalytic site; other site 198215012243 Zn-binding sites [ion binding]; other site 198215012244 DNA polymerase III subunit chi; Validated; Region: PRK05728 198215012245 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 198215012246 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 198215012247 HIGH motif; other site 198215012248 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198215012249 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 198215012250 active site 198215012251 KMSKS motif; other site 198215012252 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 198215012253 tRNA binding surface [nucleotide binding]; other site 198215012254 anticodon binding site; other site 198215012255 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 198215012256 Predicted membrane protein [Function unknown]; Region: COG4269 198215012257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 198215012258 RNase E inhibitor protein; Provisional; Region: PRK11191 198215012259 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 198215012260 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198215012261 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198215012262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012263 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012264 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012265 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012266 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 198215012267 oxidoreductase; Provisional; Region: PRK12742 198215012268 classical (c) SDRs; Region: SDR_c; cd05233 198215012269 NAD(P) binding site [chemical binding]; other site 198215012270 active site 198215012271 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 198215012272 homotrimer interaction site [polypeptide binding]; other site 198215012273 putative active site [active] 198215012274 pyrBI operon leader peptide; Provisional; Region: PRK10224 198215012275 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 198215012276 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198215012277 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198215012278 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 198215012279 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 198215012280 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 198215012281 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198215012282 homotrimer interaction site [polypeptide binding]; other site 198215012283 putative active site [active] 198215012284 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 198215012285 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 198215012286 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198215012287 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 198215012288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215012289 motif II; other site 198215012290 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 198215012291 trehalose repressor; Provisional; Region: treR; PRK09492 198215012292 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198215012293 DNA binding site [nucleotide binding] 198215012294 domain linker motif; other site 198215012295 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 198215012296 dimerization interface [polypeptide binding]; other site 198215012297 ligand binding site [chemical binding]; other site 198215012298 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 198215012299 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198215012300 active site turn [active] 198215012301 phosphorylation site [posttranslational modification] 198215012302 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198215012303 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 198215012304 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 198215012305 Ca binding site [ion binding]; other site 198215012306 active site 198215012307 catalytic site [active] 198215012308 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 198215012309 ATP cone domain; Region: ATP-cone; pfam03477 198215012310 Class III ribonucleotide reductase; Region: RNR_III; cd01675 198215012311 effector binding site; other site 198215012312 active site 198215012313 Zn binding site [ion binding]; other site 198215012314 glycine loop; other site 198215012315 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 198215012316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215012317 FeS/SAM binding site; other site 198215012318 peptidase PmbA; Provisional; Region: PRK11040 198215012319 hypothetical protein; Provisional; Region: PRK05255 198215012320 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 198215012321 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198215012322 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198215012323 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198215012324 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 198215012325 AMP binding site [chemical binding]; other site 198215012326 metal binding site [ion binding]; metal-binding site 198215012327 active site 198215012328 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198215012329 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198215012330 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198215012331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198215012332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198215012333 TM-ABC transporter signature motif; other site 198215012334 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198215012335 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198215012336 Walker A/P-loop; other site 198215012337 ATP binding site [chemical binding]; other site 198215012338 Q-loop/lid; other site 198215012339 ABC transporter signature motif; other site 198215012340 Walker B; other site 198215012341 D-loop; other site 198215012342 H-loop/switch region; other site 198215012343 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198215012344 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 198215012345 dimer interface [polypeptide binding]; other site 198215012346 substrate binding site [chemical binding]; other site 198215012347 metal binding sites [ion binding]; metal-binding site 198215012348 hypothetical protein; Provisional; Region: PRK09719 198215012349 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 198215012350 putative active site pocket [active] 198215012351 dimerization interface [polypeptide binding]; other site 198215012352 putative catalytic residue [active] 198215012353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 198215012354 Family of unknown function (DUF490); Region: DUF490; pfam04357 198215012355 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 198215012356 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198215012357 Surface antigen; Region: Bac_surface_Ag; pfam01103 198215012358 methionine sulfoxide reductase A; Provisional; Region: PRK00058 198215012359 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198215012360 Domain of unknown function DUF21; Region: DUF21; pfam01595 198215012361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198215012362 Transporter associated domain; Region: CorC_HlyC; smart01091 198215012363 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 198215012364 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 198215012365 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 198215012366 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 198215012367 active site 198215012368 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 198215012369 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 198215012370 active site 198215012371 metal binding site [ion binding]; metal-binding site 198215012372 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198215012373 Predicted transcriptional regulators [Transcription]; Region: COG1733 198215012374 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 198215012375 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 198215012376 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 198215012377 NADP binding site [chemical binding]; other site 198215012378 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198215012379 EamA-like transporter family; Region: EamA; pfam00892 198215012380 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 198215012381 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 198215012382 Hemerythrin-like domain; Region: Hr-like; cd12108 198215012383 Fe binding site [ion binding]; other site 198215012384 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 198215012385 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 198215012386 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 198215012387 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 198215012388 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 198215012389 putative NAD(P) binding site [chemical binding]; other site 198215012390 active site 198215012391 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198215012392 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012394 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012395 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012396 putative transposase OrfB; Reviewed; Region: PHA02517 198215012397 Integrase core domain; Region: rve; pfam00665 198215012398 Integrase core domain; Region: rve_3; pfam13683 198215012399 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 198215012400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012401 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012402 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012403 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012404 putative transcriptional regulator; Provisional; Region: PRK11640 198215012405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198215012406 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 198215012407 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 198215012408 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 198215012409 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 198215012410 DsbD alpha interface [polypeptide binding]; other site 198215012411 catalytic residues [active] 198215012412 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 198215012413 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 198215012414 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 198215012415 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 198215012416 Aspartase; Region: Aspartase; cd01357 198215012417 active sites [active] 198215012418 tetramer interface [polypeptide binding]; other site 198215012419 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 198215012420 putative transporter; Provisional; Region: PRK11021 198215012421 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 198215012422 oligomerisation interface [polypeptide binding]; other site 198215012423 mobile loop; other site 198215012424 roof hairpin; other site 198215012425 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 198215012426 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 198215012427 ring oligomerisation interface [polypeptide binding]; other site 198215012428 ATP/Mg binding site [chemical binding]; other site 198215012429 stacking interactions; other site 198215012430 hinge regions; other site 198215012431 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 198215012432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012433 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012434 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012435 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012436 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 198215012437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215012438 FeS/SAM binding site; other site 198215012439 elongation factor P; Validated; Region: PRK00529 198215012440 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 198215012441 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 198215012442 RNA binding site [nucleotide binding]; other site 198215012443 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 198215012444 RNA binding site [nucleotide binding]; other site 198215012445 multidrug efflux system protein; Provisional; Region: PRK11431 198215012446 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 198215012447 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 198215012448 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 198215012449 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 198215012450 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 198215012451 Iron-sulfur protein interface; other site 198215012452 proximal quinone binding site [chemical binding]; other site 198215012453 C-subunit interface; other site 198215012454 distal quinone binding site; other site 198215012455 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 198215012456 D-subunit interface [polypeptide binding]; other site 198215012457 Iron-sulfur protein interface; other site 198215012458 proximal quinone binding site [chemical binding]; other site 198215012459 distal quinone binding site [chemical binding]; other site 198215012460 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 198215012461 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 198215012462 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 198215012463 L-aspartate oxidase; Provisional; Region: PRK06175 198215012464 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198215012465 poxB regulator PoxA; Provisional; Region: PRK09350 198215012466 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 198215012467 motif 1; other site 198215012468 dimer interface [polypeptide binding]; other site 198215012469 active site 198215012470 motif 2; other site 198215012471 motif 3; other site 198215012472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012473 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012474 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012475 putative mechanosensitive channel protein; Provisional; Region: PRK10929 198215012476 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 198215012477 DNA-binding site [nucleotide binding]; DNA binding site 198215012478 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 198215012479 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198215012480 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 198215012481 GTPase RsgA; Reviewed; Region: PRK12288 198215012482 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198215012483 RNA binding site [nucleotide binding]; other site 198215012484 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 198215012485 GTPase/Zn-binding domain interface [polypeptide binding]; other site 198215012486 GTP/Mg2+ binding site [chemical binding]; other site 198215012487 G4 box; other site 198215012488 G5 box; other site 198215012489 G1 box; other site 198215012490 Switch I region; other site 198215012491 G2 box; other site 198215012492 G3 box; other site 198215012493 Switch II region; other site 198215012494 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 198215012495 catalytic site [active] 198215012496 putative active site [active] 198215012497 putative substrate binding site [chemical binding]; other site 198215012498 dimer interface [polypeptide binding]; other site 198215012499 epoxyqueuosine reductase; Region: TIGR00276 198215012500 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 198215012501 putative carbohydrate kinase; Provisional; Region: PRK10565 198215012502 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 198215012503 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 198215012504 putative substrate binding site [chemical binding]; other site 198215012505 putative ATP binding site [chemical binding]; other site 198215012506 ADP-binding protein; Provisional; Region: PRK10646 198215012507 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 198215012508 AMIN domain; Region: AMIN; pfam11741 198215012509 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198215012510 active site 198215012511 metal binding site [ion binding]; metal-binding site 198215012512 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 198215012513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215012514 ATP binding site [chemical binding]; other site 198215012515 Mg2+ binding site [ion binding]; other site 198215012516 G-X-G motif; other site 198215012517 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 198215012518 ATP binding site [chemical binding]; other site 198215012519 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 198215012520 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 198215012521 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 198215012522 bacterial Hfq-like; Region: Hfq; cd01716 198215012523 hexamer interface [polypeptide binding]; other site 198215012524 Sm1 motif; other site 198215012525 RNA binding site [nucleotide binding]; other site 198215012526 Sm2 motif; other site 198215012527 GTPase HflX; Provisional; Region: PRK11058 198215012528 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 198215012529 HflX GTPase family; Region: HflX; cd01878 198215012530 G1 box; other site 198215012531 GTP/Mg2+ binding site [chemical binding]; other site 198215012532 Switch I region; other site 198215012533 G2 box; other site 198215012534 G3 box; other site 198215012535 Switch II region; other site 198215012536 G4 box; other site 198215012537 G5 box; other site 198215012538 FtsH protease regulator HflK; Provisional; Region: PRK10930 198215012539 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 198215012540 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 198215012541 FtsH protease regulator HflC; Provisional; Region: PRK11029 198215012542 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 198215012543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 198215012544 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 198215012545 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 198215012546 GDP-binding site [chemical binding]; other site 198215012547 ACT binding site; other site 198215012548 IMP binding site; other site 198215012549 Predicted transcriptional regulator [Transcription]; Region: COG1959 198215012550 transcriptional repressor NsrR; Provisional; Region: PRK11014 198215012551 exoribonuclease R; Provisional; Region: PRK11642 198215012552 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 198215012553 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198215012554 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198215012555 RNB domain; Region: RNB; pfam00773 198215012556 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 198215012557 RNA binding site [nucleotide binding]; other site 198215012558 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 198215012559 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 198215012560 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198215012561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012562 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012563 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012564 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012565 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 198215012566 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 198215012567 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012569 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012570 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012571 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198215012572 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 198215012573 esterase; Provisional; Region: PRK10566 198215012574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198215012575 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198215012576 transcriptional repressor UlaR; Provisional; Region: PRK13509 198215012577 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198215012578 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198215012579 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 198215012580 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 198215012581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 198215012582 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 198215012583 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 198215012584 active site 198215012585 P-loop; other site 198215012586 phosphorylation site [posttranslational modification] 198215012587 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198215012588 active site 198215012589 phosphorylation site [posttranslational modification] 198215012590 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 198215012591 active site 198215012592 dimer interface [polypeptide binding]; other site 198215012593 magnesium binding site [ion binding]; other site 198215012594 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 198215012595 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 198215012596 AP (apurinic/apyrimidinic) site pocket; other site 198215012597 DNA interaction; other site 198215012598 Metal-binding active site; metal-binding site 198215012599 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 198215012600 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198215012601 intersubunit interface [polypeptide binding]; other site 198215012602 active site 198215012603 Zn2+ binding site [ion binding]; other site 198215012604 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198215012605 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 198215012606 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198215012607 dimer interface [polypeptide binding]; other site 198215012608 ssDNA binding site [nucleotide binding]; other site 198215012609 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198215012610 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 198215012611 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 198215012612 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 198215012613 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 198215012614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215012615 Transposase; Region: HTH_Tnp_1; pfam01527 198215012616 HTH-like domain; Region: HTH_21; pfam13276 198215012617 Integrase core domain; Region: rve; pfam00665 198215012618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198215012619 Integrase core domain; Region: rve; pfam00665 198215012620 Integrase core domain; Region: rve_3; pfam13683 198215012621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198215012622 Transposase; Region: HTH_Tnp_1; pfam01527 198215012623 Uncharacterized conserved protein [Function unknown]; Region: COG3586 198215012624 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 198215012625 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 198215012626 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 198215012627 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 198215012628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012629 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012630 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012631 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012632 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 198215012633 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198215012634 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 198215012635 Uncharacterized small protein [Function unknown]; Region: COG2879 198215012636 carbon starvation protein A; Provisional; Region: PRK15015 198215012637 Carbon starvation protein CstA; Region: CstA; pfam02554 198215012638 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198215012639 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 198215012640 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 198215012641 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 198215012642 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 198215012643 Cupin domain; Region: Cupin_2; pfam07883 198215012644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215012645 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 198215012646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215012647 putative substrate translocation pore; other site 198215012648 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198215012649 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 198215012650 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 198215012651 putative substrate binding pocket [chemical binding]; other site 198215012652 trimer interface [polypeptide binding]; other site 198215012653 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 198215012654 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 198215012655 putative active site [active] 198215012656 putative metal binding site [ion binding]; other site 198215012657 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 198215012658 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 198215012659 NAD binding site [chemical binding]; other site 198215012660 catalytic residues [active] 198215012661 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 198215012662 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 198215012663 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 198215012664 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 198215012665 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198215012666 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 198215012667 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198215012668 dimer interface [polypeptide binding]; other site 198215012669 ligand binding site [chemical binding]; other site 198215012670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215012671 dimerization interface [polypeptide binding]; other site 198215012672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198215012673 dimer interface [polypeptide binding]; other site 198215012674 putative CheW interface [polypeptide binding]; other site 198215012675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198215012676 D-galactonate transporter; Region: 2A0114; TIGR00893 198215012677 putative substrate translocation pore; other site 198215012678 Transcriptional regulators [Transcription]; Region: GntR; COG1802 198215012679 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198215012680 phosphoglycerol transferase I; Provisional; Region: PRK03776 198215012681 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 198215012682 hypothetical protein; Provisional; Region: PRK11667 198215012683 DNA replication protein DnaC; Validated; Region: PRK07952 198215012684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198215012685 Walker A motif; other site 198215012686 ATP binding site [chemical binding]; other site 198215012687 Walker B motif; other site 198215012688 primosomal protein DnaI; Provisional; Region: PRK02854 198215012689 hypothetical protein; Provisional; Region: PRK09917 198215012690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198215012691 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198215012692 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198215012693 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198215012694 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 198215012695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198215012696 DNA binding residues [nucleotide binding] 198215012697 dimerization interface [polypeptide binding]; other site 198215012698 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 198215012699 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198215012700 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 198215012701 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 198215012702 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 198215012703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198215012704 S-adenosylmethionine binding site [chemical binding]; other site 198215012705 DNA polymerase III subunit psi; Validated; Region: PRK06856 198215012706 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 198215012707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198215012708 Coenzyme A binding pocket [chemical binding]; other site 198215012709 dUMP phosphatase; Provisional; Region: PRK09449 198215012710 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215012711 motif II; other site 198215012712 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 198215012713 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 198215012714 G1 box; other site 198215012715 putative GEF interaction site [polypeptide binding]; other site 198215012716 GTP/Mg2+ binding site [chemical binding]; other site 198215012717 Switch I region; other site 198215012718 G2 box; other site 198215012719 G3 box; other site 198215012720 Switch II region; other site 198215012721 G4 box; other site 198215012722 G5 box; other site 198215012723 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 198215012724 periplasmic protein; Provisional; Region: PRK10568 198215012725 BON domain; Region: BON; pfam04972 198215012726 BON domain; Region: BON; pfam04972 198215012727 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 198215012728 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 198215012729 active site 198215012730 nucleophile elbow; other site 198215012731 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198215012732 active site 198215012733 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 198215012734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198215012735 FeS/SAM binding site; other site 198215012736 hypothetical protein; Provisional; Region: PRK10977 198215012737 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 198215012738 intersubunit interface [polypeptide binding]; other site 198215012739 active site 198215012740 catalytic residue [active] 198215012741 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 198215012742 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198215012743 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198215012744 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 198215012745 phosphopentomutase; Provisional; Region: PRK05362 198215012746 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 198215012747 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 198215012748 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 198215012749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215012750 non-specific DNA binding site [nucleotide binding]; other site 198215012751 salt bridge; other site 198215012752 sequence-specific DNA binding site [nucleotide binding]; other site 198215012753 hypothetical protein; Provisional; Region: PRK11246 198215012754 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 198215012755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198215012756 motif II; other site 198215012757 DNA repair protein RadA; Region: sms; TIGR00416 198215012758 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 198215012759 Walker A motif/ATP binding site; other site 198215012760 ATP binding site [chemical binding]; other site 198215012761 Walker B motif; other site 198215012762 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 198215012763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198215012764 non-specific DNA binding site [nucleotide binding]; other site 198215012765 salt bridge; other site 198215012766 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 198215012767 sequence-specific DNA binding site [nucleotide binding]; other site 198215012768 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 198215012769 active site 198215012770 (T/H)XGH motif; other site 198215012771 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 198215012772 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 198215012773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198215012774 Walker A/P-loop; other site 198215012775 ATP binding site [chemical binding]; other site 198215012776 Q-loop/lid; other site 198215012777 ABC transporter signature motif; other site 198215012778 Walker B; other site 198215012779 D-loop; other site 198215012780 H-loop/switch region; other site 198215012781 ABC transporter; Region: ABC_tran_2; pfam12848 198215012782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198215012783 lytic murein transglycosylase; Provisional; Region: PRK11619 198215012784 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198215012785 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198215012786 catalytic residue [active] 198215012787 Trp operon repressor; Provisional; Region: PRK01381 198215012788 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198215012789 catalytic core [active] 198215012790 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 198215012791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198215012792 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 198215012793 hypothetical protein; Provisional; Region: PRK10756 198215012794 CreA protein; Region: CreA; pfam05981 198215012795 DNA-binding response regulator CreB; Provisional; Region: PRK11083 198215012796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215012797 active site 198215012798 phosphorylation site [posttranslational modification] 198215012799 intermolecular recognition site; other site 198215012800 dimerization interface [polypeptide binding]; other site 198215012801 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215012802 DNA binding site [nucleotide binding] 198215012803 sensory histidine kinase CreC; Provisional; Region: PRK11100 198215012804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198215012805 dimerization interface [polypeptide binding]; other site 198215012806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198215012807 dimer interface [polypeptide binding]; other site 198215012808 phosphorylation site [posttranslational modification] 198215012809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198215012810 ATP binding site [chemical binding]; other site 198215012811 Mg2+ binding site [ion binding]; other site 198215012812 G-X-G motif; other site 198215012813 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 198215012814 two-component response regulator; Provisional; Region: PRK11173 198215012815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198215012816 active site 198215012817 phosphorylation site [posttranslational modification] 198215012818 intermolecular recognition site; other site 198215012819 dimerization interface [polypeptide binding]; other site 198215012820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198215012821 DNA binding site [nucleotide binding] 198215012822 putative RNA methyltransferase; Provisional; Region: PRK10433 198215012823 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050