-- dump date 20140620_065325 -- class Genbank::misc_feature -- table misc_feature_note -- id note 198214000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 198214000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 198214000003 putative catalytic residues [active] 198214000004 putative nucleotide binding site [chemical binding]; other site 198214000005 putative aspartate binding site [chemical binding]; other site 198214000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 198214000007 dimer interface [polypeptide binding]; other site 198214000008 putative threonine allosteric regulatory site; other site 198214000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 198214000010 putative threonine allosteric regulatory site; other site 198214000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198214000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198214000013 homoserine kinase; Region: thrB; TIGR00191 198214000014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198214000015 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 198214000016 threonine synthase; Validated; Region: PRK09225 198214000017 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 198214000018 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198214000019 catalytic residue [active] 198214000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 198214000021 hypothetical protein; Validated; Region: PRK02101 198214000022 Similar to Escherichia coli K12 inner membrane transport protein gi: 1786188 (477 aa). BLAST with identity of 98% in 476 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214000023 transaldolase-like protein; Provisional; Region: PTZ00411 198214000024 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 198214000025 active site 198214000026 dimer interface [polypeptide binding]; other site 198214000027 catalytic residue [active] 198214000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 198214000029 MPT binding site; other site 198214000030 trimer interface [polypeptide binding]; other site 198214000031 hypothetical protein; Provisional; Region: PRK10659 198214000032 hypothetical protein; Provisional; Region: PRK10236 198214000033 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 198214000034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 198214000035 hypothetical protein; Provisional; Region: PRK10154 198214000036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 198214000037 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 198214000038 nucleotide binding site [chemical binding]; other site 198214000039 NEF interaction site [polypeptide binding]; other site 198214000040 SBD interface [polypeptide binding]; other site 198214000041 chaperone protein DnaJ; Provisional; Region: PRK10767 198214000042 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198214000043 HSP70 interaction site [polypeptide binding]; other site 198214000044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 198214000045 substrate binding site [polypeptide binding]; other site 198214000046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 198214000047 Zn binding sites [ion binding]; other site 198214000048 dimer interface [polypeptide binding]; other site 198214000049 Hok/gef family; Region: HOK_GEF; pfam01848 198214000050 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 198214000051 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 198214000052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214000053 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 198214000054 putative dimerization interface [polypeptide binding]; other site 198214000055 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214000056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214000057 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214000058 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214000059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 198214000060 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 198214000061 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 198214000062 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 198214000063 active site 198214000064 Riboflavin kinase; Region: Flavokinase; smart00904 198214000065 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 198214000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 198214000067 active site 198214000068 HIGH motif; other site 198214000069 KMSKS motif; other site 198214000070 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 198214000071 tRNA binding surface [nucleotide binding]; other site 198214000072 anticodon binding site; other site 198214000073 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198214000074 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 198214000075 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 198214000076 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 198214000077 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 198214000078 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 198214000079 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 198214000080 Fe-S cluster binding site [ion binding]; other site 198214000081 substrate binding site [chemical binding]; other site 198214000082 catalytic site [active] 198214000083 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198214000084 active site 198214000085 tetramer interface [polypeptide binding]; other site 198214000086 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 198214000087 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 198214000088 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 198214000089 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 198214000090 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 198214000091 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 198214000092 catalytic site [active] 198214000093 subunit interface [polypeptide binding]; other site 198214000094 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 198214000095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198214000096 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198214000097 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 198214000098 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198214000099 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198214000100 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 198214000101 IMP binding site; other site 198214000102 dimer interface [polypeptide binding]; other site 198214000103 interdomain contacts; other site 198214000104 partial ornithine binding site; other site 198214000105 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 198214000106 carnitine operon protein CaiE; Provisional; Region: PRK13627 198214000107 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 198214000108 putative trimer interface [polypeptide binding]; other site 198214000109 putative metal binding site [ion binding]; other site 198214000110 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 198214000111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198214000112 substrate binding site [chemical binding]; other site 198214000113 oxyanion hole (OAH) forming residues; other site 198214000114 trimer interface [polypeptide binding]; other site 198214000115 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 198214000116 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 198214000117 acyl-activating enzyme (AAE) consensus motif; other site 198214000118 putative AMP binding site [chemical binding]; other site 198214000119 putative active site [active] 198214000120 putative CoA binding site [chemical binding]; other site 198214000121 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 198214000122 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 198214000123 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 198214000124 active site 198214000125 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 198214000126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 198214000127 Ligand binding site [chemical binding]; other site 198214000128 Electron transfer flavoprotein domain; Region: ETF; pfam01012 198214000129 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 198214000130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214000131 putative oxidoreductase FixC; Provisional; Region: PRK10157 198214000132 ferredoxin-like protein FixX; Provisional; Region: PRK15449 198214000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214000134 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 198214000135 putative substrate translocation pore; other site 198214000136 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 198214000137 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 198214000138 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 198214000139 TrkA-N domain; Region: TrkA_N; pfam02254 198214000140 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 198214000141 folate binding site [chemical binding]; other site 198214000142 NADP+ binding site [chemical binding]; other site 198214000143 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 198214000144 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 198214000145 active site 198214000146 metal binding site [ion binding]; metal-binding site 198214000147 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 198214000148 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 198214000149 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 198214000150 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 198214000151 SurA N-terminal domain; Region: SurA_N; pfam09312 198214000152 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198214000153 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198214000154 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 198214000155 OstA-like protein; Region: OstA; pfam03968 198214000156 Organic solvent tolerance protein; Region: OstA_C; pfam04453 198214000157 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 198214000158 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 198214000159 putative metal binding site [ion binding]; other site 198214000160 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198214000161 HSP70 interaction site [polypeptide binding]; other site 198214000162 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198214000163 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198214000164 active site 198214000165 ATP-dependent helicase HepA; Validated; Region: PRK04914 198214000166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214000167 ATP binding site [chemical binding]; other site 198214000168 putative Mg++ binding site [ion binding]; other site 198214000169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214000170 nucleotide binding region [chemical binding]; other site 198214000171 ATP-binding site [chemical binding]; other site 198214000172 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 198214000173 DNA polymerase II; Reviewed; Region: PRK05762 198214000174 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 198214000175 active site 198214000176 catalytic site [active] 198214000177 substrate binding site [chemical binding]; other site 198214000178 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 198214000179 active site 198214000180 metal-binding site 198214000181 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198214000182 intersubunit interface [polypeptide binding]; other site 198214000183 active site 198214000184 Zn2+ binding site [ion binding]; other site 198214000185 Similar to Escherichia coli K12 L-arabinose isomerase gi: 1786248 (501 aa). BLAST with identity of 98% in 499 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214000186 ribulokinase; Provisional; Region: PRK04123 198214000187 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 198214000188 N- and C-terminal domain interface [polypeptide binding]; other site 198214000189 active site 198214000190 MgATP binding site [chemical binding]; other site 198214000191 catalytic site [active] 198214000192 metal binding site [ion binding]; metal-binding site 198214000193 carbohydrate binding site [chemical binding]; other site 198214000194 homodimer interface [polypeptide binding]; other site 198214000195 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 198214000196 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198214000197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214000198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214000199 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198214000200 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 198214000201 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 198214000202 Walker A/P-loop; other site 198214000203 ATP binding site [chemical binding]; other site 198214000204 Q-loop/lid; other site 198214000205 ABC transporter signature motif; other site 198214000206 Walker B; other site 198214000207 D-loop; other site 198214000208 H-loop/switch region; other site 198214000209 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 198214000210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214000211 dimer interface [polypeptide binding]; other site 198214000212 conserved gate region; other site 198214000213 putative PBP binding loops; other site 198214000214 ABC-ATPase subunit interface; other site 198214000215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214000216 dimer interface [polypeptide binding]; other site 198214000217 conserved gate region; other site 198214000218 putative PBP binding loops; other site 198214000219 ABC-ATPase subunit interface; other site 198214000220 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 198214000221 transcriptional regulator SgrR; Provisional; Region: PRK13626 198214000222 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 198214000223 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 198214000224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214000225 sugar efflux transporter; Region: 2A0120; TIGR00899 198214000226 putative substrate translocation pore; other site 198214000227 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 198214000228 substrate binding site [chemical binding]; other site 198214000229 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 198214000230 substrate binding site [chemical binding]; other site 198214000231 ligand binding site [chemical binding]; other site 198214000232 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 198214000233 2-isopropylmalate synthase; Validated; Region: PRK00915 198214000234 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 198214000235 active site 198214000236 catalytic residues [active] 198214000237 metal binding site [ion binding]; metal-binding site 198214000238 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 198214000239 leu operon leader peptide; Provisional; Region: PRK09925 198214000240 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 198214000241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214000242 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 198214000243 putative substrate binding pocket [chemical binding]; other site 198214000244 putative dimerization interface [polypeptide binding]; other site 198214000245 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 198214000246 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198214000247 PYR/PP interface [polypeptide binding]; other site 198214000248 dimer interface [polypeptide binding]; other site 198214000249 TPP binding site [chemical binding]; other site 198214000250 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198214000251 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198214000252 TPP-binding site [chemical binding]; other site 198214000253 dimer interface [polypeptide binding]; other site 198214000254 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 198214000255 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 198214000256 putative valine binding site [chemical binding]; other site 198214000257 dimer interface [polypeptide binding]; other site 198214000258 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 198214000259 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 198214000260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214000261 DNA binding site [nucleotide binding] 198214000262 domain linker motif; other site 198214000263 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 198214000264 dimerization interface [polypeptide binding]; other site 198214000265 ligand binding site [chemical binding]; other site 198214000266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214000267 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214000268 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214000269 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214000270 mraZ protein; Region: TIGR00242 198214000271 MraZ protein; Region: MraZ; pfam02381 198214000272 MraZ protein; Region: MraZ; pfam02381 198214000273 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 198214000274 cell division protein FtsL; Provisional; Region: PRK10772 198214000275 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 198214000276 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198214000277 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198214000278 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 198214000279 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198214000280 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198214000281 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198214000282 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 198214000283 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198214000284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198214000285 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198214000286 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 198214000287 Mg++ binding site [ion binding]; other site 198214000288 putative catalytic motif [active] 198214000289 putative substrate binding site [chemical binding]; other site 198214000290 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 198214000291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198214000292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198214000293 cell division protein FtsW; Provisional; Region: PRK10774 198214000294 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 198214000295 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 198214000296 active site 198214000297 homodimer interface [polypeptide binding]; other site 198214000298 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 198214000299 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198214000300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198214000301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198214000302 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 198214000303 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 198214000304 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 198214000305 cell division protein FtsQ; Provisional; Region: PRK10775 198214000306 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 198214000307 Cell division protein FtsQ; Region: FtsQ; pfam03799 198214000308 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 198214000309 Cell division protein FtsA; Region: FtsA; pfam14450 198214000310 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214000311 Cell division protein FtsA; Region: FtsA; pfam14450 198214000312 cell division protein FtsZ; Validated; Region: PRK09330 198214000313 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 198214000314 nucleotide binding site [chemical binding]; other site 198214000315 SulA interaction site; other site 198214000316 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 198214000317 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 198214000318 SecA regulator SecM; Provisional; Region: PRK02943 198214000319 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 198214000320 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 198214000321 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 198214000322 SEC-C motif; Region: SEC-C; pfam02810 198214000323 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 198214000324 active site 198214000325 8-oxo-dGMP binding site [chemical binding]; other site 198214000326 nudix motif; other site 198214000327 metal binding site [ion binding]; metal-binding site 198214000328 DNA gyrase inhibitor; Reviewed; Region: PRK00418 198214000329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 198214000330 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 198214000331 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 198214000332 CoA-binding site [chemical binding]; other site 198214000333 ATP-binding [chemical binding]; other site 198214000334 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 198214000335 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198214000336 active site 198214000337 type IV pilin biogenesis protein; Provisional; Region: PRK10573 198214000338 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198214000339 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198214000340 'Similar to Escherichia coli K12 integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake gi: 1786296 (462 aa). BLAST with identity of 97% in 382 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct.' 198214000341 putative major pilin subunit; Provisional; Region: PRK10574 198214000342 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 198214000343 Pilin (bacterial filament); Region: Pilin; pfam00114 198214000344 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 198214000345 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 198214000346 dimerization interface [polypeptide binding]; other site 198214000347 active site 198214000348 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 198214000349 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198214000350 amidase catalytic site [active] 198214000351 Zn binding residues [ion binding]; other site 198214000352 substrate binding site [chemical binding]; other site 198214000353 regulatory protein AmpE; Provisional; Region: PRK10987 198214000354 aromatic amino acid transporter; Provisional; Region: PRK10238 198214000355 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214000356 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 198214000357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214000358 DNA-binding site [nucleotide binding]; DNA binding site 198214000359 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214000360 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 198214000361 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 198214000362 dimer interface [polypeptide binding]; other site 198214000363 TPP-binding site [chemical binding]; other site 198214000364 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 198214000365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198214000366 E3 interaction surface; other site 198214000367 lipoyl attachment site [posttranslational modification]; other site 198214000368 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198214000369 E3 interaction surface; other site 198214000370 lipoyl attachment site [posttranslational modification]; other site 198214000371 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198214000372 E3 interaction surface; other site 198214000373 lipoyl attachment site [posttranslational modification]; other site 198214000374 e3 binding domain; Region: E3_binding; pfam02817 198214000375 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198214000376 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 198214000377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214000378 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214000379 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198214000380 Similar to Escherichia coli K12 membrane protein gi: 1786308 (618 aa). BLAST with identity of 97% in 617 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214000381 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 198214000382 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 198214000383 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 198214000384 substrate binding site [chemical binding]; other site 198214000385 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 198214000386 substrate binding site [chemical binding]; other site 198214000387 ligand binding site [chemical binding]; other site 198214000388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112 198214000389 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 198214000390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214000391 S-adenosylmethionine binding site [chemical binding]; other site 198214000392 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 198214000393 multicopper oxidase; Provisional; Region: PRK10965 198214000394 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 198214000395 Domain 2 interface [polypeptide binding]; other site 198214000396 Domain 3 interface [polypeptide binding]; other site 198214000397 trinuclear Cu binding site [ion binding]; other site 198214000398 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 198214000399 Domain 1 interface [polypeptide binding]; other site 198214000400 Domain 3 interface [polypeptide binding]; other site 198214000401 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 198214000402 Domain 2 interface [polypeptide binding]; other site 198214000403 Domain 1 interface [polypeptide binding]; other site 198214000404 Type 1 (T1) Cu binding site [ion binding]; other site 198214000405 trinuclear Cu binding site [ion binding]; other site 198214000406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214000407 active site 198214000408 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 198214000409 active site clefts [active] 198214000410 zinc binding site [ion binding]; other site 198214000411 dimer interface [polypeptide binding]; other site 198214000412 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198214000413 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198214000414 Walker A/P-loop; other site 198214000415 ATP binding site [chemical binding]; other site 198214000416 Q-loop/lid; other site 198214000417 ABC transporter signature motif; other site 198214000418 Walker B; other site 198214000419 D-loop; other site 198214000420 H-loop/switch region; other site 198214000421 inner membrane transport permease; Provisional; Region: PRK15066 198214000422 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198214000423 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198214000424 active pocket/dimerization site; other site 198214000425 active site 198214000426 phosphorylation site [posttranslational modification] 198214000427 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 198214000428 putative active site [active] 198214000429 putative metal binding site [ion binding]; other site 198214000430 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 198214000431 tetramerization interface [polypeptide binding]; other site 198214000432 active site 198214000433 Uncharacterized conserved protein [Function unknown]; Region: COG5464 198214000434 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198214000435 Pantoate-beta-alanine ligase; Region: PanC; cd00560 198214000436 active site 198214000437 ATP-binding site [chemical binding]; other site 198214000438 pantoate-binding site; other site 198214000439 HXXH motif; other site 198214000440 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 198214000441 oligomerization interface [polypeptide binding]; other site 198214000442 active site 198214000443 metal binding site [ion binding]; metal-binding site 198214000444 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214000445 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 198214000446 catalytic center binding site [active] 198214000447 ATP binding site [chemical binding]; other site 198214000448 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 198214000449 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 198214000450 active site 198214000451 NTP binding site [chemical binding]; other site 198214000452 metal binding triad [ion binding]; metal-binding site 198214000453 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 198214000454 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 198214000455 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 198214000456 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 198214000457 active site 198214000458 nucleotide binding site [chemical binding]; other site 198214000459 HIGH motif; other site 198214000460 KMSKS motif; other site 198214000461 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 198214000462 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 198214000463 2'-5' RNA ligase; Provisional; Region: PRK15124 198214000464 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198214000465 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198214000466 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 198214000467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214000468 ATP binding site [chemical binding]; other site 198214000469 putative Mg++ binding site [ion binding]; other site 198214000470 helicase superfamily c-terminal domain; Region: HELICc; smart00490 198214000471 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 198214000472 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 198214000473 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 198214000474 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 198214000475 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 198214000476 Transglycosylase; Region: Transgly; pfam00912 198214000477 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198214000478 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 198214000479 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198214000480 N-terminal plug; other site 198214000481 ligand-binding site [chemical binding]; other site 198214000482 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 198214000483 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198214000484 Walker A/P-loop; other site 198214000485 ATP binding site [chemical binding]; other site 198214000486 Q-loop/lid; other site 198214000487 ABC transporter signature motif; other site 198214000488 Walker B; other site 198214000489 D-loop; other site 198214000490 H-loop/switch region; other site 198214000491 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198214000492 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198214000493 siderophore binding site; other site 198214000494 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198214000495 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214000496 ABC-ATPase subunit interface; other site 198214000497 dimer interface [polypeptide binding]; other site 198214000498 putative PBP binding regions; other site 198214000499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214000500 ABC-ATPase subunit interface; other site 198214000501 dimer interface [polypeptide binding]; other site 198214000502 putative PBP binding regions; other site 198214000503 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 198214000504 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198214000505 inhibitor-cofactor binding pocket; inhibition site 198214000506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214000507 catalytic residue [active] 198214000508 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 198214000509 Cl- selectivity filter; other site 198214000510 Cl- binding residues [ion binding]; other site 198214000511 pore gating glutamate residue; other site 198214000512 dimer interface [polypeptide binding]; other site 198214000513 H+/Cl- coupling transport residue; other site 198214000514 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 198214000515 hypothetical protein; Provisional; Region: PRK10578 198214000516 UPF0126 domain; Region: UPF0126; pfam03458 198214000517 UPF0126 domain; Region: UPF0126; pfam03458 198214000518 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198214000519 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 198214000520 cobalamin binding residues [chemical binding]; other site 198214000521 putative BtuC binding residues; other site 198214000522 dimer interface [polypeptide binding]; other site 198214000523 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 198214000524 serine endoprotease; Provisional; Region: PRK10942 198214000525 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198214000526 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198214000527 protein binding site [polypeptide binding]; other site 198214000528 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198214000529 protein binding site [polypeptide binding]; other site 198214000530 'Similar to Escherichia coli O157:H7 regulator protein of D-galactarate, D-glucarate and D-glycerate metabolism ref: NP_308193.1 (385 aa). BLAST with identity of 99% in 392 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214000531 hypothetical protein; Provisional; Region: PRK13677 198214000532 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 198214000533 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 198214000534 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 198214000535 trimer interface [polypeptide binding]; other site 198214000536 active site 198214000537 substrate binding site [chemical binding]; other site 198214000538 CoA binding site [chemical binding]; other site 198214000539 PII uridylyl-transferase; Provisional; Region: PRK05007 198214000540 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198214000541 metal binding triad; other site 198214000542 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198214000543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198214000544 Zn2+ binding site [ion binding]; other site 198214000545 Mg2+ binding site [ion binding]; other site 198214000546 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 198214000547 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 198214000548 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 198214000549 active site 198214000550 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 198214000551 rRNA interaction site [nucleotide binding]; other site 198214000552 S8 interaction site; other site 198214000553 putative laminin-1 binding site; other site 198214000554 elongation factor Ts; Provisional; Region: tsf; PRK09377 198214000555 UBA/TS-N domain; Region: UBA; pfam00627 198214000556 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 198214000557 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 198214000558 putative nucleotide binding site [chemical binding]; other site 198214000559 uridine monophosphate binding site [chemical binding]; other site 198214000560 homohexameric interface [polypeptide binding]; other site 198214000561 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 198214000562 hinge region; other site 198214000563 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 198214000564 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 198214000565 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 198214000566 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 198214000567 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 198214000568 active site 198214000569 dimer interface [polypeptide binding]; other site 198214000570 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 198214000571 zinc metallopeptidase RseP; Provisional; Region: PRK10779 198214000572 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 198214000573 active site 198214000574 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 198214000575 protein binding site [polypeptide binding]; other site 198214000576 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 198214000577 protein binding site [polypeptide binding]; other site 198214000578 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 198214000579 putative substrate binding region [chemical binding]; other site 198214000580 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 198214000581 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198214000582 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198214000583 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198214000584 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198214000585 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198214000586 Surface antigen; Region: Bac_surface_Ag; pfam01103 198214000587 periplasmic chaperone; Provisional; Region: PRK10780 198214000588 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 198214000589 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 198214000590 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 198214000591 trimer interface [polypeptide binding]; other site 198214000592 active site 198214000593 UDP-GlcNAc binding site [chemical binding]; other site 198214000594 lipid binding site [chemical binding]; lipid-binding site 198214000595 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 198214000596 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 198214000597 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 198214000598 active site 198214000599 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 198214000600 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 198214000601 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 198214000602 RNA/DNA hybrid binding site [nucleotide binding]; other site 198214000603 active site 198214000604 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 198214000605 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 198214000606 putative active site [active] 198214000607 putative PHP Thumb interface [polypeptide binding]; other site 198214000608 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 198214000609 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 198214000610 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 198214000611 generic binding surface II; other site 198214000612 generic binding surface I; other site 198214000613 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 198214000614 lysine decarboxylase LdcC; Provisional; Region: PRK15399 198214000615 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 198214000616 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198214000617 homodimer interface [polypeptide binding]; other site 198214000618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214000619 catalytic residue [active] 198214000620 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198214000621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 198214000622 putative metal binding site [ion binding]; other site 198214000623 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 198214000624 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 198214000625 Ligand Binding Site [chemical binding]; other site 198214000626 TilS substrate binding domain; Region: TilS; pfam09179 198214000627 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 198214000628 Rho-binding antiterminator; Provisional; Region: PRK11625 198214000629 hypothetical protein; Provisional; Region: PRK04964 198214000630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 198214000631 hypothetical protein; Provisional; Region: PRK09256 198214000632 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 198214000633 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 198214000634 Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015 198214000635 hypothetical protein; Provisional; Region: PRK11479 198214000636 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198214000637 prolyl-tRNA synthetase; Provisional; Region: PRK09194 198214000638 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 198214000639 dimer interface [polypeptide binding]; other site 198214000640 motif 1; other site 198214000641 active site 198214000642 motif 2; other site 198214000643 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 198214000644 putative deacylase active site [active] 198214000645 motif 3; other site 198214000646 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 198214000647 anticodon binding site; other site 198214000648 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 198214000649 homodimer interaction site [polypeptide binding]; other site 198214000650 cofactor binding site; other site 198214000651 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 198214000652 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 198214000653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214000654 dimer interface [polypeptide binding]; other site 198214000655 conserved gate region; other site 198214000656 putative PBP binding loops; other site 198214000657 ABC-ATPase subunit interface; other site 198214000658 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 198214000659 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198214000660 Walker A/P-loop; other site 198214000661 ATP binding site [chemical binding]; other site 198214000662 Q-loop/lid; other site 198214000663 ABC transporter signature motif; other site 198214000664 Walker B; other site 198214000665 D-loop; other site 198214000666 H-loop/switch region; other site 198214000667 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 198214000668 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 198214000669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214000670 active site 198214000671 motif I; other site 198214000672 motif II; other site 198214000673 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214000674 active site 198214000675 catalytic tetrad [active] 198214000676 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214000677 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214000678 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214000679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198214000680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214000681 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 198214000682 putative effector binding pocket; other site 198214000683 dimerization interface [polypeptide binding]; other site 198214000684 hypothetical protein; Provisional; Region: PRK05421 198214000685 putative catalytic site [active] 198214000686 putative metal binding site [ion binding]; other site 198214000687 putative phosphate binding site [ion binding]; other site 198214000688 putative catalytic site [active] 198214000689 putative phosphate binding site [ion binding]; other site 198214000690 putative metal binding site [ion binding]; other site 198214000691 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198214000692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214000693 S-adenosylmethionine binding site [chemical binding]; other site 198214000694 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 198214000695 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214000696 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214000697 catalytic residue [active] 198214000698 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214000699 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214000700 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 198214000701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214000702 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 198214000703 RNA/DNA hybrid binding site [nucleotide binding]; other site 198214000704 active site 198214000705 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 198214000706 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 198214000707 active site 198214000708 catalytic site [active] 198214000709 substrate binding site [chemical binding]; other site 198214000710 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 198214000711 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 198214000712 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 198214000713 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 198214000714 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214000715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000716 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214000717 HTH-like domain; Region: HTH_21; pfam13276 198214000718 Integrase core domain; Region: rve; pfam00665 198214000719 Integrase core domain; Region: rve_3; pfam13683 198214000720 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 198214000721 Terminase-like family; Region: Terminase_6; pfam03237 198214000722 HemX; Region: HemX; cl19375 198214000723 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 198214000724 P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl19542 198214000725 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 198214000726 Phage stabilisation protein; Region: Phage_stabilize; pfam11134 198214000727 Lipoprotein leucine-zipper; Region: LPP; cl11539 198214000728 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 198214000729 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 198214000730 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 198214000731 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214000732 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214000733 catalytic residue [active] 198214000734 Transposase; Region: HTH_Tnp_1; cl17663 198214000735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000736 hypothetical protein; Provisional; Region: PRK11505 198214000737 psiF repeat; Region: PsiF_repeat; pfam07769 198214000738 psiF repeat; Region: PsiF_repeat; pfam07769 198214000739 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 198214000740 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 198214000741 dimer interface [polypeptide binding]; other site 198214000742 active site 198214000743 anti-RssB factor; Provisional; Region: PRK10244 198214000744 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 198214000745 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 198214000746 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 198214000747 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 198214000748 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 198214000749 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 198214000750 microcin B17 transporter; Reviewed; Region: PRK11098 198214000751 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 198214000752 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 198214000753 Similar to Escherichia coli K12 flagellin structural protein gi: 1786572 (468 aa). BLAST with identity of 98% in 176 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214000754 putative transposase OrfB; Reviewed; Region: PHA02517 198214000755 HTH-like domain; Region: HTH_21; pfam13276 198214000756 Integrase core domain; Region: rve; pfam00665 198214000757 Integrase core domain; Region: rve_2; pfam13333 198214000758 putative transposase OrfB; Reviewed; Region: PHA02517 198214000759 HTH-like domain; Region: HTH_21; pfam13276 198214000760 Integrase core domain; Region: rve; pfam00665 198214000761 Integrase core domain; Region: rve_3; pfam13683 198214000762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000763 Transposase; Region: HTH_Tnp_1; pfam01527 198214000764 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214000765 HTH-like domain; Region: HTH_21; pfam13276 198214000766 Integrase core domain; Region: rve; pfam00665 198214000767 Integrase core domain; Region: rve_3; pfam13683 198214000768 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214000769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214000771 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214000772 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214000773 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214000774 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 198214000775 dimer interface [polypeptide binding]; other site 198214000776 active site 198214000777 Schiff base residues; other site 198214000778 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 198214000779 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 198214000780 active site 198214000781 iron coordination sites [ion binding]; other site 198214000782 substrate binding pocket [chemical binding]; other site 198214000783 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198214000784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214000785 dimer interface [polypeptide binding]; other site 198214000786 conserved gate region; other site 198214000787 putative PBP binding loops; other site 198214000788 ABC-ATPase subunit interface; other site 198214000789 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 198214000790 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198214000791 Walker A/P-loop; other site 198214000792 ATP binding site [chemical binding]; other site 198214000793 Q-loop/lid; other site 198214000794 ABC transporter signature motif; other site 198214000795 Walker B; other site 198214000796 D-loop; other site 198214000797 H-loop/switch region; other site 198214000798 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198214000799 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214000800 substrate binding pocket [chemical binding]; other site 198214000801 membrane-bound complex binding site; other site 198214000802 hinge residues; other site 198214000803 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214000804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214000805 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214000806 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214000807 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198214000808 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1786500 (71 aa). BLAST with identity of 95% in 71 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214000809 Uncharacterized conserved protein [Function unknown]; Region: COG1556 198214000810 iron-sulfur cluster-binding protein; Region: TIGR00273 198214000811 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 198214000812 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198214000813 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 198214000814 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198214000815 Cysteine-rich domain; Region: CCG; pfam02754 198214000816 Cysteine-rich domain; Region: CCG; pfam02754 198214000817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214000818 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214000819 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214000820 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214000821 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 198214000822 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 198214000823 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 198214000824 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 198214000825 PAAR motif; Region: PAAR_motif; pfam05488 198214000826 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198214000827 RHS Repeat; Region: RHS_repeat; pfam05593 198214000828 RHS Repeat; Region: RHS_repeat; pfam05593 198214000829 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 198214000830 RHS Repeat; Region: RHS_repeat; pfam05593 198214000831 RHS Repeat; Region: RHS_repeat; pfam05593 198214000832 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198214000833 RHS Repeat; Region: RHS_repeat; pfam05593 198214000834 RHS protein; Region: RHS; pfam03527 198214000835 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198214000836 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 198214000837 putative active site [active] 198214000838 catalytic triad [active] 198214000839 dimer interface [polypeptide binding]; other site 198214000840 multimer interface [polypeptide binding]; other site 198214000841 C-lysozyme inhibitor; Provisional; Region: PRK09993 198214000842 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 198214000843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 198214000844 active site 198214000845 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 198214000846 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 198214000847 dimer interface [polypeptide binding]; other site 198214000848 active site 198214000849 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 198214000850 putative active site [active] 198214000851 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 198214000852 putative dimer interface [polypeptide binding]; other site 198214000853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 198214000854 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198214000855 Similar to Escherichia coli K12 lipoprotein gi: 1786421 (250 aa). BLAST with identity of 93% in 176 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214000856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 198214000857 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 198214000858 hypothetical protein; Validated; Region: PRK06778 198214000859 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198214000860 ligand binding site [chemical binding]; other site 198214000861 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 198214000862 active site 198214000863 DNA polymerase IV; Validated; Region: PRK02406 198214000864 DNA binding site [nucleotide binding] 198214000865 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 198214000866 putative toxin YafO; Provisional; Region: PRK09885 198214000867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198214000868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214000869 Coenzyme A binding pocket [chemical binding]; other site 198214000870 hypothetical protein; Reviewed; Region: PRK09588 198214000871 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 198214000872 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 198214000873 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 198214000874 metal binding site [ion binding]; metal-binding site 198214000875 dimer interface [polypeptide binding]; other site 198214000876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214000877 active site 198214000878 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 198214000879 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 198214000880 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 198214000881 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198214000882 trimer interface [polypeptide binding]; other site 198214000883 eyelet of channel; other site 198214000884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214000885 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214000886 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214000887 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214000888 gamma-glutamyl kinase; Provisional; Region: PRK05429 198214000889 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 198214000890 nucleotide binding site [chemical binding]; other site 198214000891 homotetrameric interface [polypeptide binding]; other site 198214000892 putative phosphate binding site [ion binding]; other site 198214000893 putative allosteric binding site; other site 198214000894 PUA domain; Region: PUA; pfam01472 198214000895 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 198214000896 putative catalytic cysteine [active] 198214000897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198214000898 DNA binding site [nucleotide binding] 198214000899 Int/Topo IB signature motif; other site 198214000900 active site 198214000901 putative transposase OrfB; Reviewed; Region: PHA02517 198214000902 HTH-like domain; Region: HTH_21; pfam13276 198214000903 Integrase core domain; Region: rve; pfam00665 198214000904 Integrase core domain; Region: rve_3; pfam13683 198214000905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000906 Transposase; Region: HTH_Tnp_1; pfam01527 198214000907 integrase; Provisional; Region: int; PHA02601 198214000908 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198214000909 Protein of unknown function (DUF551); Region: DUF551; pfam04448 198214000910 Transposase; Region: HTH_Tnp_1; cl17663 198214000911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000913 Transposase; Region: HTH_Tnp_1; pfam01527 198214000914 putative transposase OrfB; Reviewed; Region: PHA02517 198214000915 HTH-like domain; Region: HTH_21; pfam13276 198214000916 Integrase core domain; Region: rve; pfam00665 198214000917 Integrase core domain; Region: rve_3; pfam13683 198214000918 Predicted membrane protein [Function unknown]; Region: COG2246 198214000919 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 198214000920 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 198214000921 Ligand binding site; other site 198214000922 Putative Catalytic site; other site 198214000923 DXD motif; other site 198214000924 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 198214000925 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214000926 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 198214000927 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198214000928 putative transposase OrfB; Reviewed; Region: PHA02517 198214000929 HTH-like domain; Region: HTH_21; pfam13276 198214000930 Integrase core domain; Region: rve; pfam00665 198214000931 Integrase core domain; Region: rve_3; pfam13683 198214000932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000933 Transposase; Region: HTH_Tnp_1; pfam01527 198214000934 integrase; Provisional; Region: int; PHA02601 198214000935 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 198214000936 Int/Topo IB signature motif; other site 198214000937 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 198214000938 putative transposase OrfB; Reviewed; Region: PHA02517 198214000939 HTH-like domain; Region: HTH_21; pfam13276 198214000940 Integrase core domain; Region: rve; pfam00665 198214000941 Integrase core domain; Region: rve_3; pfam13683 198214000942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000943 Transposase; Region: HTH_Tnp_1; pfam01527 198214000944 Transposase; Region: HTH_Tnp_1; cl17663 198214000945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214000946 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 198214000947 MASE2 domain; Region: MASE2; pfam05230 198214000948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198214000949 metal binding site [ion binding]; metal-binding site 198214000950 active site 198214000951 I-site; other site 198214000952 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 198214000953 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 198214000954 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 198214000955 hypothetical protein; Validated; Region: PRK00124 198214000956 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 198214000957 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 198214000958 ADP binding site [chemical binding]; other site 198214000959 magnesium binding site [ion binding]; other site 198214000960 putative shikimate binding site; other site 198214000961 hypothetical protein; Provisional; Region: PRK10380 198214000962 hypothetical protein; Provisional; Region: PRK10481 198214000963 hypothetical protein; Provisional; Region: PRK10579 198214000964 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 198214000965 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 198214000966 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 198214000967 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198214000968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214000969 nucleotide binding site [chemical binding]; other site 198214000970 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1786594 (81 aa). BLAST with identity of 97% in 47 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214000971 MFS transport protein AraJ; Provisional; Region: PRK10091 198214000972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214000973 putative substrate translocation pore; other site 198214000974 exonuclease subunit SbcC; Provisional; Region: PRK10246 198214000975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214000976 Walker A/P-loop; other site 198214000977 ATP binding site [chemical binding]; other site 198214000978 Q-loop/lid; other site 198214000979 HemX; Region: HemX; cl19375 198214000980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214000981 Q-loop/lid; other site 198214000982 ABC transporter signature motif; other site 198214000983 Walker B; other site 198214000984 D-loop; other site 198214000985 H-loop/switch region; other site 198214000986 exonuclease subunit SbcD; Provisional; Region: PRK10966 198214000987 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 198214000988 active site 198214000989 metal binding site [ion binding]; metal-binding site 198214000990 DNA binding site [nucleotide binding] 198214000991 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 198214000992 transcriptional regulator PhoB; Provisional; Region: PRK10161 198214000993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214000994 active site 198214000995 phosphorylation site [posttranslational modification] 198214000996 intermolecular recognition site; other site 198214000997 dimerization interface [polypeptide binding]; other site 198214000998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214000999 DNA binding site [nucleotide binding] 198214001000 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 198214001001 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 198214001002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198214001003 putative active site [active] 198214001004 heme pocket [chemical binding]; other site 198214001005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214001006 dimer interface [polypeptide binding]; other site 198214001007 phosphorylation site [posttranslational modification] 198214001008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214001009 ATP binding site [chemical binding]; other site 198214001010 Mg2+ binding site [ion binding]; other site 198214001011 G-X-G motif; other site 198214001012 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 198214001013 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198214001014 putative proline-specific permease; Provisional; Region: proY; PRK10580 198214001015 Spore germination protein; Region: Spore_permease; cl17796 198214001016 maltodextrin glucosidase; Provisional; Region: PRK10785 198214001017 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 198214001018 homodimer interface [polypeptide binding]; other site 198214001019 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 198214001020 active site 198214001021 homodimer interface [polypeptide binding]; other site 198214001022 catalytic site [active] 198214001023 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 198214001024 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 198214001025 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 198214001026 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 198214001027 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 198214001028 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 198214001029 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198214001030 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 198214001031 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 198214001032 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198214001033 Protein export membrane protein; Region: SecD_SecF; pfam02355 198214001034 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198214001035 active site 198214001036 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 198214001037 hypothetical protein; Provisional; Region: PRK11530 198214001038 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 198214001039 ATP cone domain; Region: ATP-cone; pfam03477 198214001040 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 198214001041 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 198214001042 catalytic motif [active] 198214001043 Zn binding site [ion binding]; other site 198214001044 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 198214001045 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 198214001046 homopentamer interface [polypeptide binding]; other site 198214001047 active site 198214001048 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 198214001049 thiamine monophosphate kinase; Provisional; Region: PRK05731 198214001050 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 198214001051 ATP binding site [chemical binding]; other site 198214001052 dimerization interface [polypeptide binding]; other site 198214001053 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 198214001054 tetramer interfaces [polypeptide binding]; other site 198214001055 binuclear metal-binding site [ion binding]; other site 198214001056 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 198214001057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214001058 active site 198214001059 catalytic tetrad [active] 198214001060 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 198214001061 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 198214001062 TPP-binding site; other site 198214001063 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198214001064 PYR/PP interface [polypeptide binding]; other site 198214001065 dimer interface [polypeptide binding]; other site 198214001066 TPP binding site [chemical binding]; other site 198214001067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198214001068 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198214001069 substrate binding pocket [chemical binding]; other site 198214001070 chain length determination region; other site 198214001071 active site lid residues [active] 198214001072 substrate-Mg2+ binding site; other site 198214001073 catalytic residues [active] 198214001074 aspartate-rich region 1; other site 198214001075 aspartate-rich region 2; other site 198214001076 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 198214001077 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 198214001078 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 198214001079 conserved cys residue [active] 198214001080 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 198214001081 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 198214001082 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 198214001083 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 198214001084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 198214001085 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198214001086 Sel1-like repeats; Region: SEL1; smart00671 198214001087 Sel1-like repeats; Region: SEL1; smart00671 198214001088 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214001089 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 198214001090 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 198214001091 putative active site [active] 198214001092 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 198214001093 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 198214001094 Subunit I/III interface [polypeptide binding]; other site 198214001095 Subunit III/IV interface [polypeptide binding]; other site 198214001096 Similar to Escherichia coli K12 cytochrome o ubiquinol oxidase subunit I gi: 1786634 (664 aa). BLAST with identity of 99% in 663 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001097 Similar to Escherichia coli K12 cytochrome o ubiquinol oxidase subunit II gi: 1786635 (316 aa). BLAST with identity of 98% in 165 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214001098 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214001099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214001100 Homeodomain-like domain; Region: HTH_23; pfam13384 198214001101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001102 Transposase; Region: HTH_Tnp_1; pfam01527 198214001103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214001104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198214001105 putative substrate translocation pore; other site 198214001106 hypothetical protein; Provisional; Region: PRK11627 198214001107 transcriptional regulator BolA; Provisional; Region: PRK11628 198214001108 trigger factor; Provisional; Region: tig; PRK01490 198214001109 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 198214001110 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198214001111 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 198214001112 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 198214001113 oligomer interface [polypeptide binding]; other site 198214001114 active site residues [active] 198214001115 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 198214001116 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 198214001117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214001118 Walker A motif; other site 198214001119 ATP binding site [chemical binding]; other site 198214001120 Walker B motif; other site 198214001121 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198214001122 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 198214001123 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 198214001124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214001125 Walker A motif; other site 198214001126 ATP binding site [chemical binding]; other site 198214001127 Walker B motif; other site 198214001128 arginine finger; other site 198214001129 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198214001130 histone-like DNA-binding protein HU; Region: HU; cd13831 198214001131 dimer interface [polypeptide binding]; other site 198214001132 DNA binding site [nucleotide binding] 198214001133 periplasmic folding chaperone; Provisional; Region: PRK10788 198214001134 SurA N-terminal domain; Region: SurA_N_3; cl07813 198214001135 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 198214001136 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 198214001137 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 198214001138 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 198214001139 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 198214001140 active site 198214001141 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 198214001142 Ligand Binding Site [chemical binding]; other site 198214001143 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198214001144 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 198214001145 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198214001146 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 198214001147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214001148 active site 198214001149 motif I; other site 198214001150 motif II; other site 198214001151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198214001152 dimerization interface [polypeptide binding]; other site 198214001153 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198214001154 putative DNA binding site [nucleotide binding]; other site 198214001155 putative Zn2+ binding site [ion binding]; other site 198214001156 AsnC family; Region: AsnC_trans_reg; pfam01037 198214001157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198214001158 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 198214001159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214001160 Walker A/P-loop; other site 198214001161 ATP binding site [chemical binding]; other site 198214001162 Q-loop/lid; other site 198214001163 ABC transporter signature motif; other site 198214001164 Walker B; other site 198214001165 D-loop; other site 198214001166 H-loop/switch region; other site 198214001167 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 198214001168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198214001169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214001170 Walker A/P-loop; other site 198214001171 ATP binding site [chemical binding]; other site 198214001172 Q-loop/lid; other site 198214001173 ABC transporter signature motif; other site 198214001174 Walker B; other site 198214001175 D-loop; other site 198214001176 H-loop/switch region; other site 198214001177 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 198214001178 ammonium transporter; Provisional; Region: PRK10666 198214001179 acyl-CoA thioesterase II; Provisional; Region: PRK10526 198214001180 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 198214001181 active site 198214001182 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 198214001183 catalytic triad [active] 198214001184 dimer interface [polypeptide binding]; other site 198214001185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 198214001186 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214001187 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214001188 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214001189 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 198214001190 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198214001191 DNA binding site [nucleotide binding] 198214001192 active site 198214001193 Uncharacterized conserved protein [Function unknown]; Region: COG5507 198214001194 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 198214001195 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198214001196 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198214001197 Inner membrane protein YlaC; Region: YlaC; pfam10777 198214001198 Similar to Escherichia coli K12 transferase gi: 1786664 (184 aa). BLAST with identity of 98% in 183 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214001199 gene expression modulator; Provisional; Region: PRK10945 198214001200 Hha toxicity attenuator; Provisional; Region: PRK10667 198214001201 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 198214001202 MMPL family; Region: MMPL; cl14618 198214001203 MMPL family; Region: MMPL; cl14618 198214001204 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 198214001205 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 198214001206 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214001207 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 198214001208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214001209 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 198214001210 hypothetical protein; Provisional; Region: PRK11281 198214001211 FSIP1 family; Region: FSIP1; pfam15554 198214001212 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 198214001213 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198214001214 hypothetical protein; Provisional; Region: PRK11038 198214001215 primosomal replication protein N''; Provisional; Region: PRK10093 198214001216 hypothetical protein; Provisional; Region: PRK10527 198214001217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214001218 active site 198214001219 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 198214001220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214001221 Walker A motif; other site 198214001222 ATP binding site [chemical binding]; other site 198214001223 Walker B motif; other site 198214001224 DNA polymerase III subunit delta'; Validated; Region: PRK08485 198214001225 arginine finger; other site 198214001226 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 198214001227 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 198214001228 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 198214001229 hypothetical protein; Validated; Region: PRK00153 198214001230 recombination protein RecR; Reviewed; Region: recR; PRK00076 198214001231 RecR protein; Region: RecR; pfam02132 198214001232 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 198214001233 putative active site [active] 198214001234 putative metal-binding site [ion binding]; other site 198214001235 tetramer interface [polypeptide binding]; other site 198214001236 heat shock protein 90; Provisional; Region: PRK05218 198214001237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214001238 ATP binding site [chemical binding]; other site 198214001239 Mg2+ binding site [ion binding]; other site 198214001240 G-X-G motif; other site 198214001241 Hsp90 protein; Region: HSP90; pfam00183 198214001242 adenylate kinase; Reviewed; Region: adk; PRK00279 198214001243 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 198214001244 AMP-binding site [chemical binding]; other site 198214001245 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 198214001246 ferrochelatase; Region: hemH; TIGR00109 198214001247 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 198214001248 C-terminal domain interface [polypeptide binding]; other site 198214001249 active site 198214001250 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 198214001251 active site 198214001252 N-terminal domain interface [polypeptide binding]; other site 198214001253 acetyl esterase; Provisional; Region: PRK10162 198214001254 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 198214001255 inosine/guanosine kinase; Provisional; Region: PRK15074 198214001256 adenosine kinase; Provisional; Region: PTZ00247 198214001257 substrate binding site [chemical binding]; other site 198214001258 ATP binding site [chemical binding]; other site 198214001259 putative cation:proton antiport protein; Provisional; Region: PRK10669 198214001260 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 198214001261 TrkA-N domain; Region: TrkA_N; pfam02254 198214001262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214001263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198214001264 putative substrate translocation pore; other site 198214001265 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 198214001266 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 198214001267 active site 198214001268 metal binding site [ion binding]; metal-binding site 198214001269 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198214001270 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 198214001271 putative deacylase active site [active] 198214001272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 198214001273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214001274 non-specific DNA binding site [nucleotide binding]; other site 198214001275 salt bridge; other site 198214001276 sequence-specific DNA binding site [nucleotide binding]; other site 198214001277 copper exporting ATPase; Provisional; Region: copA; PRK10671 198214001278 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198214001279 metal-binding site [ion binding] 198214001280 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198214001281 metal-binding site [ion binding] 198214001282 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198214001283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214001284 motif II; other site 198214001285 glutaminase; Reviewed; Region: PRK12356 198214001286 amino acid transporter; Region: 2A0306; TIGR00909 198214001287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 198214001288 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 198214001289 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 198214001290 DNA binding residues [nucleotide binding] 198214001291 dimer interface [polypeptide binding]; other site 198214001292 copper binding site [ion binding]; other site 198214001293 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 198214001294 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 198214001295 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 198214001296 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 198214001297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214001298 Walker A/P-loop; other site 198214001299 ATP binding site [chemical binding]; other site 198214001300 Q-loop/lid; other site 198214001301 ABC transporter signature motif; other site 198214001302 Walker B; other site 198214001303 D-loop; other site 198214001304 H-loop/switch region; other site 198214001305 TIGR00245 family protein; Region: TIGR00245 198214001306 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 198214001307 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 198214001308 Tetratricopeptide repeat; Region: TPR_20; pfam14561 198214001309 short chain dehydrogenase; Validated; Region: PRK06182 198214001310 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198214001311 NADP binding site [chemical binding]; other site 198214001312 active site 198214001313 steroid binding site; other site 198214001314 Similar to Escherichia coli K12 acyl-CoA thioesterase I; also functions as protease I gi: 1786702 (209 aa). BLAST with identity of 99% in 208 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001315 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 198214001316 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198214001317 Walker A/P-loop; other site 198214001318 ATP binding site [chemical binding]; other site 198214001319 Q-loop/lid; other site 198214001320 ABC transporter signature motif; other site 198214001321 Walker B; other site 198214001322 D-loop; other site 198214001323 H-loop/switch region; other site 198214001324 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 198214001325 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 198214001326 active site residue [active] 198214001327 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 198214001328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214001329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214001330 dimerization interface [polypeptide binding]; other site 198214001331 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 198214001332 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 198214001333 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198214001334 Bacterial transcriptional regulator; Region: IclR; pfam01614 198214001335 glyoxylate carboligase; Provisional; Region: PRK11269 198214001336 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198214001337 PYR/PP interface [polypeptide binding]; other site 198214001338 dimer interface [polypeptide binding]; other site 198214001339 TPP binding site [chemical binding]; other site 198214001340 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198214001341 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 198214001342 TPP-binding site [chemical binding]; other site 198214001343 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214001344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214001345 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214001346 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214001347 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 198214001348 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 198214001349 allantoate amidohydrolase; Region: AllC; TIGR03176 198214001350 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 198214001351 active site 198214001352 metal binding site [ion binding]; metal-binding site 198214001353 dimer interface [polypeptide binding]; other site 198214001354 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 198214001355 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 198214001356 putative substrate binding site [chemical binding]; other site 198214001357 nucleotide binding site [chemical binding]; other site 198214001358 nucleotide binding site [chemical binding]; other site 198214001359 homodimer interface [polypeptide binding]; other site 198214001360 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 198214001361 ATP-grasp domain; Region: ATP-grasp; pfam02222 198214001362 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 198214001363 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 198214001364 putative active site [active] 198214001365 putative metal binding site [ion binding]; other site 198214001366 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 198214001367 substrate binding site [chemical binding]; other site 198214001368 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 198214001369 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 198214001370 active site 198214001371 HIGH motif; other site 198214001372 KMSKS motif; other site 198214001373 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 198214001374 tRNA binding surface [nucleotide binding]; other site 198214001375 anticodon binding site; other site 198214001376 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 198214001377 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214001378 RNA binding surface [nucleotide binding]; other site 198214001379 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 198214001380 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 198214001381 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 198214001382 homodimer interface [polypeptide binding]; other site 198214001383 NADP binding site [chemical binding]; other site 198214001384 substrate binding site [chemical binding]; other site 198214001385 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 198214001386 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 198214001387 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 198214001388 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 198214001389 PapC N-terminal domain; Region: PapC_N; pfam13954 198214001390 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214001391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214001392 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214001393 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214001394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214001395 active site 198214001396 phosphorylation site [posttranslational modification] 198214001397 intermolecular recognition site; other site 198214001398 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198214001399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214001400 hypothetical protein; Provisional; Region: PRK09936 198214001401 'Similar to Escherichia coli K12 bacteriophage N4 receptor, outer membrane protein gi: 1786780 (991 aa). BLAST with identity of 97% in 989 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214001402 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 198214001403 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 198214001404 active site 198214001405 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 198214001406 sensor kinase CusS; Provisional; Region: PRK09835 198214001407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214001408 dimerization interface [polypeptide binding]; other site 198214001409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214001410 dimer interface [polypeptide binding]; other site 198214001411 phosphorylation site [posttranslational modification] 198214001412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214001413 ATP binding site [chemical binding]; other site 198214001414 Mg2+ binding site [ion binding]; other site 198214001415 G-X-G motif; other site 198214001416 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 198214001417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214001418 active site 198214001419 phosphorylation site [posttranslational modification] 198214001420 intermolecular recognition site; other site 198214001421 dimerization interface [polypeptide binding]; other site 198214001422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214001423 DNA binding site [nucleotide binding] 198214001424 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 198214001425 Outer membrane efflux protein; Region: OEP; pfam02321 198214001426 Outer membrane efflux protein; Region: OEP; pfam02321 198214001427 periplasmic copper-binding protein; Provisional; Region: PRK09838 198214001428 Transposase; Region: HTH_Tnp_1; cl17663 198214001429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001430 Similar to Shigella flexneri Bifunctional tail protein sp: Q9XJP3 (624 aa). BLAST with identity of 96% in 392 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214001431 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 198214001432 HTH-like domain; Region: HTH_21; pfam13276 198214001433 Integrase core domain; Region: rve; pfam00665 198214001434 Integrase core domain; Region: rve_3; pfam13683 198214001435 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214001436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001437 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 198214001438 phenylalanine transporter; Provisional; Region: PRK10249 198214001439 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214001440 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 198214001441 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198214001442 Similar to Escherichia coli K12 oxygen-insensitive NAD(P)H nitroreductase gi: 1786792 (218 aa). BLAST with identity of 98% in 663 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214001443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214001444 hypothetical protein; Provisional; Region: PRK10250 198214001445 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 198214001446 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 198214001447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001448 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214001449 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214001450 putative transposase OrfB; Reviewed; Region: PHA02517 198214001451 HTH-like domain; Region: HTH_21; pfam13276 198214001452 Integrase core domain; Region: rve; pfam00665 198214001453 Integrase core domain; Region: rve_3; pfam13683 198214001454 Transposase; Region: HTH_Tnp_1; cl17663 198214001455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001457 Transposase; Region: HTH_Tnp_1; pfam01527 198214001458 putative transposase OrfB; Reviewed; Region: PHA02517 198214001459 HTH-like domain; Region: HTH_21; pfam13276 198214001460 Integrase core domain; Region: rve; pfam00665 198214001461 Integrase core domain; Region: rve_2; pfam13333 198214001462 Hok/gef family; Region: HOK_GEF; pfam01848 198214001463 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 198214001464 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 198214001465 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 198214001466 outer membrane receptor FepA; Provisional; Region: PRK13524 198214001467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198214001468 N-terminal plug; other site 198214001469 ligand-binding site [chemical binding]; other site 198214001470 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 198214001471 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 198214001472 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 198214001473 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 198214001474 Condensation domain; Region: Condensation; cl19241 198214001475 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198214001476 acyl-activating enzyme (AAE) consensus motif; other site 198214001477 AMP binding site [chemical binding]; other site 198214001478 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198214001479 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 198214001480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214001481 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214001482 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214001483 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214001484 Similar to Escherichia coli K12 ferric enterobactin (enterochelin) transport gi: 1786802 (378 aa). BLAST with identity of 97% in 378 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001485 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 198214001486 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198214001487 Walker A/P-loop; other site 198214001488 ATP binding site [chemical binding]; other site 198214001489 Q-loop/lid; other site 198214001490 ABC transporter signature motif; other site 198214001491 Walker B; other site 198214001492 D-loop; other site 198214001493 H-loop/switch region; other site 198214001494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214001495 ABC-ATPase subunit interface; other site 198214001496 dimer interface [polypeptide binding]; other site 198214001497 putative PBP binding regions; other site 198214001498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214001499 ABC-ATPase subunit interface; other site 198214001500 dimer interface [polypeptide binding]; other site 198214001501 putative PBP binding regions; other site 198214001502 enterobactin exporter EntS; Provisional; Region: PRK10489 198214001503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214001504 putative substrate translocation pore; other site 198214001505 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 198214001506 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198214001507 siderophore binding site; other site 198214001508 'Similar to Escherichia coli K12 isochorismate hydroxymutase 2, enterochelin biosynthesis gi: 1786809 (392 aa). BLAST with identity of 97% in 392 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214001509 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 198214001510 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 198214001511 acyl-activating enzyme (AAE) consensus motif; other site 198214001512 active site 198214001513 AMP binding site [chemical binding]; other site 198214001514 substrate binding site [chemical binding]; other site 198214001515 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 198214001516 hydrophobic substrate binding pocket; other site 198214001517 active site 198214001518 conserved cis-peptide bond; other site 198214001519 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 198214001520 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 198214001521 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 198214001522 putative NAD(P) binding site [chemical binding]; other site 198214001523 active site 198214001524 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198214001525 CoenzymeA binding site [chemical binding]; other site 198214001526 subunit interaction site [polypeptide binding]; other site 198214001527 PHB binding site; other site 198214001528 carbon starvation protein A; Provisional; Region: PRK15015 198214001529 Carbon starvation protein CstA; Region: CstA; pfam02554 198214001530 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198214001531 Uncharacterized small protein [Function unknown]; Region: COG2879 198214001532 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 198214001533 putative active site [active] 198214001534 metal binding site [ion binding]; metal-binding site 198214001535 methionine aminotransferase; Validated; Region: PRK09082 198214001536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214001537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214001538 homodimer interface [polypeptide binding]; other site 198214001539 catalytic residue [active] 198214001540 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1786817 (210 aa). BLAST with identity of 99% in 627 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214001541 putative transposase OrfB; Reviewed; Region: PHA02517 198214001542 HTH-like domain; Region: HTH_21; pfam13276 198214001543 Integrase core domain; Region: rve; pfam00665 198214001544 Integrase core domain; Region: rve_3; pfam13683 198214001545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001546 Transposase; Region: HTH_Tnp_1; cl17663 198214001547 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1786818 (407 aa). BLAST with identity of 98% in 817 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214001548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001549 Transposase; Region: HTH_Tnp_1; pfam01527 198214001550 putative transposase OrfB; Reviewed; Region: PHA02517 198214001551 HTH-like domain; Region: HTH_21; pfam13276 198214001552 Integrase core domain; Region: rve; pfam00665 198214001553 Integrase core domain; Region: rve_2; pfam13333 198214001554 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 198214001555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214001556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214001557 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 198214001558 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 198214001559 dimerization domain [polypeptide binding]; other site 198214001560 dimer interface [polypeptide binding]; other site 198214001561 catalytic residues [active] 198214001562 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 198214001563 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 198214001564 dimer interface [polypeptide binding]; other site 198214001565 decamer (pentamer of dimers) interface [polypeptide binding]; other site 198214001566 catalytic triad [active] 198214001567 peroxidatic and resolving cysteines [active] 198214001568 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 198214001569 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 198214001570 catalytic residue [active] 198214001571 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 198214001572 catalytic residues [active] 198214001573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214001574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214001575 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198214001576 Ligand Binding Site [chemical binding]; other site 198214001577 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 198214001578 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198214001579 NAD binding site [chemical binding]; other site 198214001580 catalytic Zn binding site [ion binding]; other site 198214001581 structural Zn binding site [ion binding]; other site 198214001582 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 198214001583 Rnk N-terminus; Region: Rnk_N; pfam14760 198214001584 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198214001585 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 198214001586 B1 nucleotide binding pocket [chemical binding]; other site 198214001587 B2 nucleotide binding pocket [chemical binding]; other site 198214001588 CAS motifs; other site 198214001589 active site 198214001590 Similar to Escherichia coli K12 a membrane protein gi: 1786829 (488 aa). BLAST with identity of 99% in 487 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001591 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 198214001592 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1786831 (184 aa). BLAST with identity of 98% in 183 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001593 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 198214001594 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198214001595 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 198214001596 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 198214001597 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 198214001598 putative active site [active] 198214001599 (T/H)XGH motif; other site 198214001600 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214001601 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 198214001602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214001603 active site 198214001604 motif I; other site 198214001605 motif II; other site 198214001606 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198214001607 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 198214001608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214001609 Walker A/P-loop; other site 198214001610 ATP binding site [chemical binding]; other site 198214001611 Q-loop/lid; other site 198214001612 ABC transporter signature motif; other site 198214001613 Walker B; other site 198214001614 D-loop; other site 198214001615 H-loop/switch region; other site 198214001616 molybdenum-pterin binding domain; Region: Mop; TIGR00638 198214001617 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198214001618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214001619 dimer interface [polypeptide binding]; other site 198214001620 conserved gate region; other site 198214001621 putative PBP binding loops; other site 198214001622 ABC-ATPase subunit interface; other site 198214001623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214001624 substrate binding pocket [chemical binding]; other site 198214001625 membrane-bound complex binding site; other site 198214001626 hinge residues; other site 198214001627 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 198214001628 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 198214001629 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 198214001630 molybdenum-pterin binding domain; Region: Mop; TIGR00638 198214001631 TOBE domain; Region: TOBE; pfam03459 198214001632 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 198214001633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 198214001634 Walker A/P-loop; other site 198214001635 ATP binding site [chemical binding]; other site 198214001636 Q-loop/lid; other site 198214001637 ABC transporter signature motif; other site 198214001638 Walker B; other site 198214001639 D-loop; other site 198214001640 H-loop/switch region; other site 198214001641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214001642 Walker A/P-loop; other site 198214001643 ATP binding site [chemical binding]; other site 198214001644 Q-loop/lid; other site 198214001645 ABC transporter signature motif; other site 198214001646 Walker B; other site 198214001647 D-loop; other site 198214001648 H-loop/switch region; other site 198214001649 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 198214001650 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 198214001651 NAD binding site [chemical binding]; other site 198214001652 homodimer interface [polypeptide binding]; other site 198214001653 active site 198214001654 substrate binding site [chemical binding]; other site 198214001655 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 198214001656 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 198214001657 dimer interface [polypeptide binding]; other site 198214001658 active site 198214001659 galactokinase; Provisional; Region: PRK05101 198214001660 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 198214001661 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198214001662 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 198214001663 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 198214001664 active site 198214001665 catalytic residues [active] 198214001666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198214001667 catalytic core [active] 198214001668 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 198214001669 YbgS-like protein; Region: YbgS; pfam13985 198214001670 zinc transporter ZitB; Provisional; Region: PRK03557 198214001671 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 198214001672 quinolinate synthetase; Provisional; Region: PRK09375 198214001673 tol-pal system protein YbgF; Provisional; Region: PRK10803 198214001674 Tetratricopeptide repeat; Region: TPR_6; pfam13174 198214001675 Tetratricopeptide repeat; Region: TPR_6; pfam13174 198214001676 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 198214001677 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198214001678 ligand binding site [chemical binding]; other site 198214001679 translocation protein TolB; Provisional; Region: tolB; PRK03629 198214001680 TolB amino-terminal domain; Region: TolB_N; pfam04052 198214001681 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198214001682 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198214001683 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198214001684 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 198214001685 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 198214001686 TolA C-terminal; Region: TolA; pfam06519 198214001687 colicin uptake protein TolR; Provisional; Region: PRK11024 198214001688 colicin uptake protein TolQ; Provisional; Region: PRK10801 198214001689 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 198214001690 active site 198214001691 hypothetical protein; Provisional; Region: PRK10588 198214001692 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 198214001693 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 198214001694 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 198214001695 alpha-mannosidase; Provisional; Region: PRK09819 198214001696 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 198214001697 active site 198214001698 metal binding site [ion binding]; metal-binding site 198214001699 catalytic site [active] 198214001700 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 198214001701 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 198214001702 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 198214001703 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214001704 active site 198214001705 phosphorylation site [posttranslational modification] 198214001706 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198214001707 active site 198214001708 P-loop; other site 198214001709 phosphorylation site [posttranslational modification] 198214001710 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 198214001711 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 198214001712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214001713 DNA-binding site [nucleotide binding]; DNA binding site 198214001714 UTRA domain; Region: UTRA; pfam07702 198214001715 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 198214001716 CoA binding domain; Region: CoA_binding; pfam02629 198214001717 CoA-ligase; Region: Ligase_CoA; pfam00549 198214001718 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 198214001719 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 198214001720 CoA-ligase; Region: Ligase_CoA; pfam00549 198214001721 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 198214001722 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198214001723 E3 interaction surface; other site 198214001724 lipoyl attachment site [posttranslational modification]; other site 198214001725 e3 binding domain; Region: E3_binding; pfam02817 198214001726 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198214001727 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 198214001728 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 198214001729 TPP-binding site [chemical binding]; other site 198214001730 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 198214001731 dimer interface [polypeptide binding]; other site 198214001732 PYR/PP interface [polypeptide binding]; other site 198214001733 TPP binding site [chemical binding]; other site 198214001734 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 198214001735 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 198214001736 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 198214001737 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 198214001738 L-aspartate oxidase; Provisional; Region: PRK06175 198214001739 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198214001740 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 198214001741 SdhC subunit interface [polypeptide binding]; other site 198214001742 proximal heme binding site [chemical binding]; other site 198214001743 cardiolipin binding site; other site 198214001744 Iron-sulfur protein interface; other site 198214001745 proximal quinone binding site [chemical binding]; other site 198214001746 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 198214001747 Iron-sulfur protein interface; other site 198214001748 proximal quinone binding site [chemical binding]; other site 198214001749 SdhD (CybS) interface [polypeptide binding]; other site 198214001750 proximal heme binding site [chemical binding]; other site 198214001751 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 198214001752 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 198214001753 dimer interface [polypeptide binding]; other site 198214001754 active site 198214001755 citrylCoA binding site [chemical binding]; other site 198214001756 NADH binding [chemical binding]; other site 198214001757 cationic pore residues; other site 198214001758 oxalacetate/citrate binding site [chemical binding]; other site 198214001759 coenzyme A binding site [chemical binding]; other site 198214001760 catalytic triad [active] 198214001761 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198214001762 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 198214001763 PapC N-terminal domain; Region: PapC_N; pfam13954 198214001764 Outer membrane usher protein; Region: Usher; pfam00577 198214001765 PapC C-terminal domain; Region: PapC_C; pfam13953 198214001766 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 198214001767 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 198214001768 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 198214001769 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1786935 (363 aa). BLAST with identity of 96% in 369 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214001770 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 198214001771 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 198214001772 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 198214001773 endonuclease VIII; Provisional; Region: PRK10445 198214001774 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 198214001775 DNA binding site [nucleotide binding] 198214001776 catalytic residue [active] 198214001777 putative catalytic residues [active] 198214001778 H2TH interface [polypeptide binding]; other site 198214001779 intercalation triad [nucleotide binding]; other site 198214001780 substrate specificity determining residue; other site 198214001781 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198214001782 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198214001783 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 198214001784 putative active site [active] 198214001785 Similar to Escherichia coli K12 carboxylase gi: 1786930 (311 aa). BLAST with identity of 97% in 310 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001786 Allophanate hydrolase subunit 1; Region: AHS1; cl19310 198214001787 metal-binding protein; Provisional; Region: PRK10799 198214001788 dipeptide/tripeptide permease D; Provisional; Region: PRK15462 198214001789 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 198214001790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214001791 putative substrate translocation pore; other site 198214001792 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 198214001793 DNA photolyase; Region: DNA_photolyase; pfam00875 198214001794 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 198214001795 hypothetical protein; Provisional; Region: PRK10167 198214001796 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 198214001797 PAAR motif; Region: PAAR_motif; cl15808 198214001798 Elongation factor 1 gamma, conserved domain; Region: EF1G; pfam00647 198214001799 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198214001800 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 198214001801 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 198214001802 RHS Repeat; Region: RHS_repeat; pfam05593 198214001803 RHS Repeat; Region: RHS_repeat; pfam05593 198214001804 RHS Repeat; Region: RHS_repeat; pfam05593 198214001805 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214001806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214001807 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214001808 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214001809 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 198214001810 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 198214001811 'Similar to Escherichia coli K12 ATPase of high-affinity potassium transport system, B chain gi: 1786914 (683 aa). BLAST with identity of 97% in 683 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214001812 Similar to Escherichia coli K12 sensor for high-affinity potassium transport system gi: 1786912 (895 aa). BLAST with identity of 97% in 894 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001813 Similar to Escherichia coli K12 regulator of kdp operon (transcriptional effector) gi: 1786911 (226 aa). BLAST with identity of 96% in 229 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001814 'Similar to Escherichia coli K12 ornithine decarboxylase isozyme, inducible gi: 1786909 (733 aa). BLAST with identity of 95% in 688 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214001815 putrescine transporter; Provisional; Region: potE; PRK10655 198214001816 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 198214001817 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 198214001818 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 198214001819 active site 198214001820 substrate binding site [chemical binding]; other site 198214001821 metal binding site [ion binding]; metal-binding site 198214001822 replication initiation regulator SeqA; Provisional; Region: PRK11187 198214001823 acyl-CoA esterase; Provisional; Region: PRK10673 198214001824 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198214001825 LexA regulated protein; Provisional; Region: PRK11675 198214001826 flavodoxin FldA; Validated; Region: PRK09267 198214001827 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198214001828 metal binding site 2 [ion binding]; metal-binding site 198214001829 putative DNA binding helix; other site 198214001830 metal binding site 1 [ion binding]; metal-binding site 198214001831 dimer interface [polypeptide binding]; other site 198214001832 structural Zn2+ binding site [ion binding]; other site 198214001833 YbfN-like lipoprotein; Region: YbfN; pfam13982 198214001834 outer membrane porin, OprD family; Region: OprD; pfam03573 198214001835 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 198214001836 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 198214001837 active site 198214001838 HIGH motif; other site 198214001839 KMSKS motif; other site 198214001840 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 198214001841 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 198214001842 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198214001843 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198214001844 active site turn [active] 198214001845 phosphorylation site [posttranslational modification] 198214001846 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198214001847 HPr interaction site; other site 198214001848 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198214001849 active site 198214001850 phosphorylation site [posttranslational modification] 198214001851 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198214001852 active site 198214001853 trimer interface [polypeptide binding]; other site 198214001854 allosteric site; other site 198214001855 active site lid [active] 198214001856 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198214001857 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 198214001858 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 198214001859 active site 198214001860 dimer interface [polypeptide binding]; other site 198214001861 MarR family; Region: MarR_2; cl17246 198214001862 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198214001863 ROK family; Region: ROK; pfam00480 198214001864 Similar to Escherichia coli K12 N-acetylglucosamine metabolism gi: 1786890 (251 aa). BLAST with identity of 97% in 251 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001865 asparagine synthetase B; Provisional; Region: asnB; PRK09431 198214001866 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 198214001867 active site 198214001868 dimer interface [polypeptide binding]; other site 198214001869 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 198214001870 Ligand Binding Site [chemical binding]; other site 198214001871 Molecular Tunnel; other site 198214001872 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 198214001873 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 198214001874 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 198214001875 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198214001876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214001877 FeS/SAM binding site; other site 198214001878 TRAM domain; Region: TRAM; pfam01938 198214001879 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 198214001880 PhoH-like protein; Region: PhoH; pfam02562 198214001881 metal-binding heat shock protein; Provisional; Region: PRK00016 198214001882 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 198214001883 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198214001884 Transporter associated domain; Region: CorC_HlyC; smart01091 198214001885 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 198214001886 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 198214001887 putative active site [active] 198214001888 catalytic triad [active] 198214001889 putative dimer interface [polypeptide binding]; other site 198214001890 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 198214001891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214001892 substrate binding pocket [chemical binding]; other site 198214001893 membrane-bound complex binding site; other site 198214001894 hinge residues; other site 198214001895 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198214001896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214001897 dimer interface [polypeptide binding]; other site 198214001898 conserved gate region; other site 198214001899 putative PBP binding loops; other site 198214001900 ABC-ATPase subunit interface; other site 198214001901 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198214001902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214001903 dimer interface [polypeptide binding]; other site 198214001904 conserved gate region; other site 198214001905 putative PBP binding loops; other site 198214001906 ABC-ATPase subunit interface; other site 198214001907 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198214001908 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198214001909 Walker A/P-loop; other site 198214001910 ATP binding site [chemical binding]; other site 198214001911 Q-loop/lid; other site 198214001912 ABC transporter signature motif; other site 198214001913 Walker B; other site 198214001914 D-loop; other site 198214001915 H-loop/switch region; other site 198214001916 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198214001917 active site 198214001918 tetramer interface [polypeptide binding]; other site 198214001919 Similar to Escherichia coli K12 dnaK protein gi: 1786870 (557 aa). BLAST with identity of 98% in 554 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214001920 DnaJ domain; Region: DnaJ; pfam00226 198214001921 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 198214001922 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198214001923 Sel1-like repeats; Region: SEL1; smart00671 198214001924 Sel1-like repeats; Region: SEL1; smart00671 198214001925 Sel1-like repeats; Region: SEL1; smart00671 198214001926 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198214001927 HSP70 interaction site [polypeptide binding]; other site 198214001928 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 198214001929 Sel1-like repeats; Region: SEL1; smart00671 198214001930 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198214001931 Sel1-like repeats; Region: SEL1; smart00671 198214001932 Sel1-like repeats; Region: SEL1; smart00671 198214001933 Sel1-like repeats; Region: SEL1; smart00671 198214001934 Sel1-like repeats; Region: SEL1; smart00671 198214001935 Sel1-like repeats; Region: SEL1; smart00671 198214001936 Sel1-like repeats; Region: SEL1; smart00671 198214001937 hypothetical protein; Provisional; Region: PRK11032 198214001938 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 198214001939 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 198214001940 active site 198214001941 HIGH motif; other site 198214001942 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198214001943 KMSKS motif; other site 198214001944 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 198214001945 tRNA binding surface [nucleotide binding]; other site 198214001946 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 198214001947 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 198214001948 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 198214001949 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 198214001950 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 198214001951 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 198214001952 active site 198214001953 (T/H)XGH motif; other site 198214001954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198214001955 catalytic core [active] 198214001956 ribosome-associated protein; Provisional; Region: PRK11538 198214001957 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 198214001958 penicillin-binding protein 2; Provisional; Region: PRK10795 198214001959 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 198214001960 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198214001961 cell wall shape-determining protein; Provisional; Region: PRK10794 198214001962 rare lipoprotein A; Provisional; Region: PRK10672 198214001963 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 198214001964 Sporulation related domain; Region: SPOR; pfam05036 198214001965 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 198214001966 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 198214001967 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 198214001968 hypothetical protein; Provisional; Region: PRK04998 198214001969 lipoate-protein ligase B; Provisional; Region: PRK14342 198214001970 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 198214001971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214001972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214001973 dimerization interface [polypeptide binding]; other site 198214001974 lipoyl synthase; Provisional; Region: PRK05481 198214001975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214001976 FeS/SAM binding site; other site 198214001977 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 198214001978 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 198214001979 putative active site [active] 198214001980 catalytic triad [active] 198214001981 putative dimer interface [polypeptide binding]; other site 198214001982 chromosome condensation membrane protein; Provisional; Region: PRK14196 198214001983 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198214001984 DNA-binding site [nucleotide binding]; DNA binding site 198214001985 RNA-binding motif; other site 198214001986 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 198214001987 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 198214001988 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 198214001989 Similar to Escherichia coli K12 sequence similarity to Shigella regulator gi: 1786838 (227 aa). BLAST with identity of 98% in 113 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214001990 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 198214001991 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 198214001992 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 198214001993 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 198214001994 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 198214001995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214001996 Transposase; Region: HTH_Tnp_1; pfam01527 198214001997 putative transposase OrfB; Reviewed; Region: PHA02517 198214001998 HTH-like domain; Region: HTH_21; pfam13276 198214001999 Integrase core domain; Region: rve; pfam00665 198214002000 Integrase core domain; Region: rve_3; pfam13683 198214002001 Domain of unknown function (DUF336); Region: DUF336; cl01249 198214002002 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 198214002003 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 198214002004 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 198214002005 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 198214002006 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214002007 HTH-like domain; Region: HTH_21; pfam13276 198214002008 Integrase core domain; Region: rve; pfam00665 198214002009 Integrase core domain; Region: rve_3; pfam13683 198214002010 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214002011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002012 Phage terminase large subunit; Region: Terminase_3; cl12054 198214002013 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 198214002014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002015 Transposase; Region: HTH_Tnp_1; cl17663 198214002016 putative transposase OrfB; Reviewed; Region: PHA02517 198214002017 HTH-like domain; Region: HTH_21; pfam13276 198214002018 Integrase core domain; Region: rve; pfam00665 198214002019 Integrase core domain; Region: rve_3; pfam13683 198214002020 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 198214002021 putative transposase OrfB; Reviewed; Region: PHA02517 198214002022 HTH-like domain; Region: HTH_21; pfam13276 198214002023 Integrase core domain; Region: rve; pfam00665 198214002024 Integrase core domain; Region: rve_3; pfam13683 198214002025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002026 Transposase; Region: HTH_Tnp_1; pfam01527 198214002027 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 198214002028 active site 198214002029 metal binding site [ion binding]; metal-binding site 198214002030 interdomain interaction site; other site 198214002031 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 198214002032 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 198214002033 LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528 198214002034 putative transposase OrfB; Reviewed; Region: PHA02517 198214002035 HTH-like domain; Region: HTH_21; pfam13276 198214002036 Integrase core domain; Region: rve; pfam00665 198214002037 Integrase core domain; Region: rve_3; pfam13683 198214002038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002039 Transposase; Region: HTH_Tnp_1; cl17663 198214002040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214002041 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198214002042 Walker A motif; other site 198214002043 ATP binding site [chemical binding]; other site 198214002044 Walker B motif; other site 198214002045 arginine finger; other site 198214002046 replicative DNA helicase; Region: DnaB; TIGR00665 198214002047 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 198214002048 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 198214002049 Walker A motif; other site 198214002050 ATP binding site [chemical binding]; other site 198214002051 Walker B motif; other site 198214002052 DNA binding loops [nucleotide binding] 198214002053 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 198214002054 Lysis protein S; Region: Lysis_S; pfam04971 198214002055 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 198214002056 catalytic residues [active] 198214002057 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 198214002058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002059 Transposase; Region: HTH_Tnp_1; pfam01527 198214002060 Transposase; Region: HTH_Tnp_1; cl17663 198214002061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002062 putative transposase OrfB; Reviewed; Region: PHA02517 198214002063 HTH-like domain; Region: HTH_21; pfam13276 198214002064 Integrase core domain; Region: rve; pfam00665 198214002065 Integrase core domain; Region: rve_3; pfam13683 198214002066 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 198214002067 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 198214002068 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 198214002069 tandem repeat interface [polypeptide binding]; other site 198214002070 oligomer interface [polypeptide binding]; other site 198214002071 active site residues [active] 198214002072 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 198214002073 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 198214002074 DNA packaging protein FI; Region: Packaging_FI; pfam14000 198214002075 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 198214002076 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 198214002077 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 198214002078 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 198214002079 Phage tail protein; Region: Phage_tail_3; pfam08813 198214002080 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 198214002081 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 198214002082 Minor tail protein T; Region: Phage_tail_T; pfam06223 198214002083 Phage-related minor tail protein [Function unknown]; Region: COG5281 198214002084 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 198214002085 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 198214002086 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 198214002087 Phage-related protein [Function unknown]; Region: COG4718 198214002088 Phage-related protein [Function unknown]; Region: gp18; COG4672 198214002089 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 198214002090 MPN+ (JAMM) motif; other site 198214002091 Zinc-binding site [ion binding]; other site 198214002092 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198214002093 NlpC/P60 family; Region: NLPC_P60; cl17555 198214002094 Phage-related protein, tail component [Function unknown]; Region: COG4723 198214002095 Phage-related protein, tail component [Function unknown]; Region: COG4733 198214002096 Putative phage tail protein; Region: Phage-tail_3; pfam13550 198214002097 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198214002098 Interdomain contacts; other site 198214002099 Cytokine receptor motif; other site 198214002100 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 198214002101 Fibronectin type III protein; Region: DUF3672; pfam12421 198214002102 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 198214002103 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214002104 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214002105 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198214002106 Leucine rich repeat; Region: LRR_8; pfam13855 198214002107 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214002108 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 198214002109 substrate binding site [chemical binding]; other site 198214002110 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198214002111 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198214002112 inhibitor-cofactor binding pocket; inhibition site 198214002113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214002114 catalytic residue [active] 198214002115 biotin synthase; Provisional; Region: PRK15108 198214002116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214002117 FeS/SAM binding site; other site 198214002118 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 198214002119 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 198214002120 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 198214002121 substrate-cofactor binding pocket; other site 198214002122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214002123 catalytic residue [active] 198214002124 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 198214002125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214002126 S-adenosylmethionine binding site [chemical binding]; other site 198214002127 AAA domain; Region: AAA_26; pfam13500 198214002128 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 198214002129 active site 198214002130 ADP binding site [chemical binding]; other site 198214002131 excinuclease ABC subunit B; Provisional; Region: PRK05298 198214002132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214002133 ATP binding site [chemical binding]; other site 198214002134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214002135 nucleotide binding region [chemical binding]; other site 198214002136 ATP-binding site [chemical binding]; other site 198214002137 Ultra-violet resistance protein B; Region: UvrB; pfam12344 198214002138 UvrB/uvrC motif; Region: UVR; pfam02151 198214002139 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 198214002140 phosphate binding site [ion binding]; other site 198214002141 putative substrate binding pocket [chemical binding]; other site 198214002142 dimer interface [polypeptide binding]; other site 198214002143 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 198214002144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214002145 FeS/SAM binding site; other site 198214002146 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 198214002147 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 198214002148 MPT binding site; other site 198214002149 trimer interface [polypeptide binding]; other site 198214002150 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 198214002151 trimer interface [polypeptide binding]; other site 198214002152 dimer interface [polypeptide binding]; other site 198214002153 putative active site [active] 198214002154 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 198214002155 MoaE interaction surface [polypeptide binding]; other site 198214002156 MoeB interaction surface [polypeptide binding]; other site 198214002157 thiocarboxylated glycine; other site 198214002158 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 198214002159 MoaE homodimer interface [polypeptide binding]; other site 198214002160 MoaD interaction [polypeptide binding]; other site 198214002161 active site residues [active] 198214002162 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 198214002163 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 198214002164 Predicted integral membrane protein [Function unknown]; Region: COG0392 198214002165 cardiolipin synthase 2; Provisional; Region: PRK11263 198214002166 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198214002167 putative active site [active] 198214002168 catalytic site [active] 198214002169 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 198214002170 putative active site [active] 198214002171 catalytic site [active] 198214002172 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 198214002173 putative catalytic site [active] 198214002174 putative metal binding site [ion binding]; other site 198214002175 putative phosphate binding site [ion binding]; other site 198214002176 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 198214002177 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198214002178 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198214002179 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198214002180 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 198214002181 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198214002182 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198214002183 Walker A/P-loop; other site 198214002184 ATP binding site [chemical binding]; other site 198214002185 Q-loop/lid; other site 198214002186 ABC transporter signature motif; other site 198214002187 Walker B; other site 198214002188 D-loop; other site 198214002189 H-loop/switch region; other site 198214002190 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 198214002191 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198214002192 Walker A/P-loop; other site 198214002193 ATP binding site [chemical binding]; other site 198214002194 Q-loop/lid; other site 198214002195 ABC transporter signature motif; other site 198214002196 Walker B; other site 198214002197 D-loop; other site 198214002198 H-loop/switch region; other site 198214002199 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 198214002200 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214002201 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214002202 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 198214002203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214002204 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 198214002205 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 198214002206 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198214002207 ATP binding site [chemical binding]; other site 198214002208 Mg++ binding site [ion binding]; other site 198214002209 motif III; other site 198214002210 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214002211 nucleotide binding region [chemical binding]; other site 198214002212 ATP-binding site [chemical binding]; other site 198214002213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 198214002214 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 198214002215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 198214002216 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198214002217 glycosyl transferase family protein; Provisional; Region: PRK08136 198214002218 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198214002219 putative dehydrogenase; Provisional; Region: PRK10098 198214002220 hypothetical protein; Provisional; Region: PRK10259 198214002221 hypothetical protein; Provisional; Region: PRK11019 198214002222 Uncharacterized iron-regulated protein [Function unknown]; Region: PiuC; COG3128 198214002223 Similar to Escherichia coli K12 outer membrane receptor for iron transport gi: 1787024 (761 aa). BLAST with identity of 98% in 1240 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214002224 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214002225 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214002226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214002227 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 198214002228 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 198214002229 putative mechanosensitive channel protein; Provisional; Region: PRK11465 198214002230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198214002231 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 198214002232 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198214002233 Walker A/P-loop; other site 198214002234 ATP binding site [chemical binding]; other site 198214002235 Q-loop/lid; other site 198214002236 ABC transporter signature motif; other site 198214002237 Walker B; other site 198214002238 D-loop; other site 198214002239 H-loop/switch region; other site 198214002240 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 198214002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002242 dimer interface [polypeptide binding]; other site 198214002243 conserved gate region; other site 198214002244 putative PBP binding loops; other site 198214002245 ABC-ATPase subunit interface; other site 198214002246 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 198214002247 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214002248 substrate binding pocket [chemical binding]; other site 198214002249 membrane-bound complex binding site; other site 198214002250 hinge residues; other site 198214002251 Ferritin-like domain; Region: Ferritin; pfam00210 198214002252 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 198214002253 dimerization interface [polypeptide binding]; other site 198214002254 DPS ferroxidase diiron center [ion binding]; other site 198214002255 ion pore; other site 198214002256 threonine and homoserine efflux system; Provisional; Region: PRK10532 198214002257 EamA-like transporter family; Region: EamA; pfam00892 198214002258 outer membrane protein X; Provisional; Region: ompX; PRK09408 198214002259 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 198214002260 Sulfatase; Region: Sulfatase; pfam00884 198214002261 manganese transport regulator MntR; Provisional; Region: PRK11050 198214002262 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 198214002263 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 198214002264 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198214002265 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 198214002266 transmembrane helices; other site 198214002267 L,D-transpeptidase; Provisional; Region: PRK10260 198214002268 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198214002269 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 198214002270 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214002271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214002272 Walker A/P-loop; other site 198214002273 ATP binding site [chemical binding]; other site 198214002274 ABC transporter signature motif; other site 198214002275 Walker B; other site 198214002276 ABC transporter; Region: ABC_tran_2; pfam12848 198214002277 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214002278 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 198214002279 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 198214002280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214002281 active site 198214002282 motif I; other site 198214002283 motif II; other site 198214002284 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198214002285 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 198214002286 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 198214002287 dimer interface [polypeptide binding]; other site 198214002288 active site 198214002289 glycine loop; other site 198214002290 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 198214002291 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 198214002292 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 198214002293 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 198214002294 active site 198214002295 intersubunit interactions; other site 198214002296 catalytic residue [active] 198214002297 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 198214002298 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198214002299 ATP binding site [chemical binding]; other site 198214002300 substrate interface [chemical binding]; other site 198214002301 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 198214002302 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 198214002303 dimer interface [polypeptide binding]; other site 198214002304 putative functional site; other site 198214002305 putative MPT binding site; other site 198214002306 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 198214002307 catalytic nucleophile [active] 198214002308 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 198214002309 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214002310 Walker A/P-loop; other site 198214002311 ATP binding site [chemical binding]; other site 198214002312 Q-loop/lid; other site 198214002313 ABC transporter signature motif; other site 198214002314 Walker B; other site 198214002315 D-loop; other site 198214002316 H-loop/switch region; other site 198214002317 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214002318 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214002319 Walker A/P-loop; other site 198214002320 ATP binding site [chemical binding]; other site 198214002321 Q-loop/lid; other site 198214002322 ABC transporter signature motif; other site 198214002323 Walker B; other site 198214002324 D-loop; other site 198214002325 H-loop/switch region; other site 198214002326 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214002327 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198214002328 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 198214002329 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 198214002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002331 dimer interface [polypeptide binding]; other site 198214002332 conserved gate region; other site 198214002333 putative PBP binding loops; other site 198214002334 ABC-ATPase subunit interface; other site 198214002335 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 198214002336 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198214002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002338 dimer interface [polypeptide binding]; other site 198214002339 conserved gate region; other site 198214002340 putative PBP binding loops; other site 198214002341 ABC-ATPase subunit interface; other site 198214002342 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787055 (783 aa). BLAST with identity of 98% in 775 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214002343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198214002344 metal binding site [ion binding]; metal-binding site 198214002345 active site 198214002346 I-site; other site 198214002347 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 198214002348 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198214002349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214002350 FeS/SAM binding site; other site 198214002351 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 198214002352 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 198214002353 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 198214002354 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198214002355 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 198214002356 putative C-terminal domain interface [polypeptide binding]; other site 198214002357 putative GSH binding site (G-site) [chemical binding]; other site 198214002358 putative dimer interface [polypeptide binding]; other site 198214002359 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 198214002360 N-terminal domain interface [polypeptide binding]; other site 198214002361 dimer interface [polypeptide binding]; other site 198214002362 substrate binding pocket (H-site) [chemical binding]; other site 198214002363 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 198214002364 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 198214002365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002366 Transposase; Region: HTH_Tnp_1; pfam01527 198214002367 putative transposase OrfB; Reviewed; Region: PHA02517 198214002368 HTH-like domain; Region: HTH_21; pfam13276 198214002369 Integrase core domain; Region: rve; pfam00665 198214002370 Integrase core domain; Region: rve_3; pfam13683 198214002371 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 198214002372 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 198214002373 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198214002374 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214002375 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198214002376 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 198214002377 active site 198214002378 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 198214002379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214002380 putative substrate translocation pore; other site 198214002381 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 198214002382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214002383 active site 198214002384 motif I; other site 198214002385 motif II; other site 198214002386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214002387 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198214002388 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 198214002389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214002390 putative substrate translocation pore; other site 198214002391 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 198214002392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214002393 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 198214002394 putative transporter; Provisional; Region: PRK04972 198214002395 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 198214002396 TrkA-C domain; Region: TrkA_C; pfam02080 198214002397 TrkA-C domain; Region: TrkA_C; pfam02080 198214002398 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 198214002399 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 198214002400 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 198214002401 GSH binding site [chemical binding]; other site 198214002402 catalytic residues [active] 198214002403 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 198214002404 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214002405 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 198214002406 dimer interface [polypeptide binding]; other site 198214002407 NADPH bind site [chemical binding]; other site 198214002408 FMN binding site [chemical binding]; other site 198214002409 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 198214002410 RimK-like ATP-grasp domain; Region: RimK; pfam08443 198214002411 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 198214002412 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 198214002413 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 198214002414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214002415 Walker A/P-loop; other site 198214002416 ATP binding site [chemical binding]; other site 198214002417 Q-loop/lid; other site 198214002418 ABC transporter signature motif; other site 198214002419 Walker B; other site 198214002420 D-loop; other site 198214002421 H-loop/switch region; other site 198214002422 TOBE domain; Region: TOBE_2; pfam08402 198214002423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002424 dimer interface [polypeptide binding]; other site 198214002425 conserved gate region; other site 198214002426 putative PBP binding loops; other site 198214002427 ABC-ATPase subunit interface; other site 198214002428 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198214002429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002430 dimer interface [polypeptide binding]; other site 198214002431 conserved gate region; other site 198214002432 putative PBP binding loops; other site 198214002433 ABC-ATPase subunit interface; other site 198214002434 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 198214002435 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 198214002436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214002437 S-adenosylmethionine binding site [chemical binding]; other site 198214002438 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 198214002439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214002440 substrate binding pocket [chemical binding]; other site 198214002441 membrane-bound complex binding site; other site 198214002442 hinge residues; other site 198214002443 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 198214002444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002445 dimer interface [polypeptide binding]; other site 198214002446 conserved gate region; other site 198214002447 putative PBP binding loops; other site 198214002448 ABC-ATPase subunit interface; other site 198214002449 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198214002450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002451 dimer interface [polypeptide binding]; other site 198214002452 conserved gate region; other site 198214002453 putative PBP binding loops; other site 198214002454 ABC-ATPase subunit interface; other site 198214002455 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 198214002456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214002457 substrate binding pocket [chemical binding]; other site 198214002458 membrane-bound complex binding site; other site 198214002459 hinge residues; other site 198214002460 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 198214002461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214002462 Walker A/P-loop; other site 198214002463 ATP binding site [chemical binding]; other site 198214002464 Q-loop/lid; other site 198214002465 ABC transporter signature motif; other site 198214002466 Walker B; other site 198214002467 D-loop; other site 198214002468 H-loop/switch region; other site 198214002469 putative lipoprotein; Provisional; Region: PRK10533 198214002470 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198214002471 hypothetical protein; Provisional; Region: PRK02877 198214002472 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 198214002473 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198214002474 amidase catalytic site [active] 198214002475 Zn binding residues [ion binding]; other site 198214002476 substrate binding site [chemical binding]; other site 198214002477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198214002478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198214002479 NAD(P) binding site [chemical binding]; other site 198214002480 active site 198214002481 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 198214002482 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 198214002483 putative NAD(P) binding site [chemical binding]; other site 198214002484 putative active site [active] 198214002485 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 198214002486 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 198214002487 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 198214002488 tetramer interface [polypeptide binding]; other site 198214002489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214002490 catalytic residue [active] 198214002491 pyruvate dehydrogenase; Provisional; Region: PRK09124 198214002492 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 198214002493 PYR/PP interface [polypeptide binding]; other site 198214002494 dimer interface [polypeptide binding]; other site 198214002495 tetramer interface [polypeptide binding]; other site 198214002496 TPP binding site [chemical binding]; other site 198214002497 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198214002498 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 198214002499 TPP-binding site [chemical binding]; other site 198214002500 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 198214002501 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 198214002502 FAD binding pocket [chemical binding]; other site 198214002503 FAD binding motif [chemical binding]; other site 198214002504 phosphate binding motif [ion binding]; other site 198214002505 beta-alpha-beta structure motif; other site 198214002506 NAD binding pocket [chemical binding]; other site 198214002507 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198214002508 catalytic loop [active] 198214002509 iron binding site [ion binding]; other site 198214002510 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 198214002511 cubane metal cluster [ion binding]; other site 198214002512 hybrid metal cluster; other site 198214002513 Predicted membrane protein [Function unknown]; Region: COG2431 198214002514 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214002515 HTH-like domain; Region: HTH_21; pfam13276 198214002516 Integrase core domain; Region: rve; pfam00665 198214002517 Integrase core domain; Region: rve_3; pfam13683 198214002518 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214002519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002520 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 198214002521 amphipathic channel; other site 198214002522 Asn-Pro-Ala signature motifs; other site 198214002523 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214002524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214002525 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214002526 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214002527 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 198214002528 AAA domain; Region: AAA_21; pfam13304 198214002529 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 198214002530 putative active site [active] 198214002531 putative metal-binding site [ion binding]; other site 198214002532 Protein of unknown function (DUF535); Region: DUF535; pfam04393 198214002533 macrolide transporter subunit MacA; Provisional; Region: PRK11578 198214002534 HemX; Region: HemX; cl19375 198214002535 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214002536 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214002537 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 198214002538 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198214002539 Walker A/P-loop; other site 198214002540 ATP binding site [chemical binding]; other site 198214002541 Q-loop/lid; other site 198214002542 ABC transporter signature motif; other site 198214002543 Walker B; other site 198214002544 D-loop; other site 198214002545 H-loop/switch region; other site 198214002546 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198214002547 FtsX-like permease family; Region: FtsX; pfam02687 198214002548 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198214002549 DNA-binding site [nucleotide binding]; DNA binding site 198214002550 RNA-binding motif; other site 198214002551 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 198214002552 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 198214002553 Clp amino terminal domain; Region: Clp_N; pfam02861 198214002554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214002555 Walker A motif; other site 198214002556 ATP binding site [chemical binding]; other site 198214002557 Walker B motif; other site 198214002558 arginine finger; other site 198214002559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214002560 Walker A motif; other site 198214002561 ATP binding site [chemical binding]; other site 198214002562 Walker B motif; other site 198214002563 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 198214002564 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 198214002565 rRNA binding site [nucleotide binding]; other site 198214002566 predicted 30S ribosome binding site; other site 198214002567 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 198214002568 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 198214002569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198214002570 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 198214002571 Walker A/P-loop; other site 198214002572 ATP binding site [chemical binding]; other site 198214002573 Q-loop/lid; other site 198214002574 ABC transporter signature motif; other site 198214002575 Walker B; other site 198214002576 D-loop; other site 198214002577 H-loop/switch region; other site 198214002578 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 198214002579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198214002580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214002581 Walker A/P-loop; other site 198214002582 ATP binding site [chemical binding]; other site 198214002583 Q-loop/lid; other site 198214002584 ABC transporter signature motif; other site 198214002585 Walker B; other site 198214002586 D-loop; other site 198214002587 H-loop/switch region; other site 198214002588 thioredoxin reductase; Provisional; Region: PRK10262 198214002589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214002590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214002591 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 198214002592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198214002593 putative DNA binding site [nucleotide binding]; other site 198214002594 putative Zn2+ binding site [ion binding]; other site 198214002595 AsnC family; Region: AsnC_trans_reg; pfam01037 198214002596 DNA translocase FtsK; Provisional; Region: PRK10263 198214002597 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 198214002598 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198214002599 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198214002600 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 198214002601 periplasmic chaperone LolA; Region: lolA; TIGR00547 198214002602 recombination factor protein RarA; Reviewed; Region: PRK13342 198214002603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214002604 Walker A motif; other site 198214002605 ATP binding site [chemical binding]; other site 198214002606 Walker B motif; other site 198214002607 arginine finger; other site 198214002608 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 198214002609 seryl-tRNA synthetase; Provisional; Region: PRK05431 198214002610 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 198214002611 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 198214002612 dimer interface [polypeptide binding]; other site 198214002613 active site 198214002614 motif 1; other site 198214002615 motif 2; other site 198214002616 motif 3; other site 198214002617 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 198214002618 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214002619 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 198214002620 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 198214002621 catalytic triad [active] 198214002622 dimer interface [polypeptide binding]; other site 198214002623 conserved cis-peptide bond; other site 198214002624 putative MFS family transporter protein; Provisional; Region: PRK03633 198214002625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214002626 putative substrate translocation pore; other site 198214002627 Homeodomain-like domain; Region: HTH_23; pfam13384 198214002628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002629 Transposase; Region: HTH_Tnp_1; pfam01527 198214002630 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214002631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214002632 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214002633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214002634 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214002635 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214002636 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214002637 putative transposase OrfB; Reviewed; Region: PHA02517 198214002638 HTH-like domain; Region: HTH_21; pfam13276 198214002639 Integrase core domain; Region: rve; pfam00665 198214002640 Integrase core domain; Region: rve_3; pfam13683 198214002641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002642 Transposase; Region: HTH_Tnp_1; cl17663 198214002643 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 198214002644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002645 Transposase; Region: HTH_Tnp_1; pfam01527 198214002646 putative transposase OrfB; Reviewed; Region: PHA02517 198214002647 HTH-like domain; Region: HTH_21; pfam13276 198214002648 Integrase core domain; Region: rve; pfam00665 198214002649 Integrase core domain; Region: rve_3; pfam13683 198214002650 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 198214002651 Hok/gef family; Region: HOK_GEF; pfam01848 198214002652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 198214002653 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 198214002654 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198214002655 Similar to Escherichia coli K12 DNA replication factor ref: NP_415878.1 (248 aa). BLAST with identity of 92% in 248 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214002656 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 198214002657 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 198214002658 transcriptional repressor DicA; Reviewed; Region: PRK09706 198214002659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214002660 non-specific DNA binding site [nucleotide binding]; other site 198214002661 salt bridge; other site 198214002662 sequence-specific DNA binding site [nucleotide binding]; other site 198214002663 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 198214002664 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214002665 HTH-like domain; Region: HTH_21; pfam13276 198214002666 Integrase core domain; Region: rve; pfam00665 198214002667 Integrase core domain; Region: rve_3; pfam13683 198214002668 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214002669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002670 Ash protein family; Region: Phage_ASH; pfam10554 198214002671 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 198214002672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002673 Transposase; Region: HTH_Tnp_1; pfam01527 198214002674 putative transposase OrfB; Reviewed; Region: PHA02517 198214002675 HTH-like domain; Region: HTH_21; pfam13276 198214002676 Integrase core domain; Region: rve; pfam00665 198214002677 Integrase core domain; Region: rve_3; pfam13683 198214002678 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 198214002679 putative transposase OrfB; Reviewed; Region: PHA02517 198214002680 HTH-like domain; Region: HTH_21; pfam13276 198214002681 Integrase core domain; Region: rve; pfam00665 198214002682 Integrase core domain; Region: rve_3; pfam13683 198214002683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002684 Transposase; Region: HTH_Tnp_1; pfam01527 198214002685 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214002686 Similar to Shigella flexneri IpaH9.8 gb: AAC23714.1 (545 aa). BLAST with identity of 64% in 604 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214002687 6-phosphogluconolactonase; Provisional; Region: PRK11028 198214002688 Similar to Escherichia coli K12 transcriptional regulator LYSR-type gi: 1786984 (339 aa). BLAST with identity of 97% in 338 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214002689 PrpF protein; Region: PrpF; cl19418 198214002690 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 198214002691 anion transporter; Region: dass; TIGR00785 198214002692 transmembrane helices; other site 198214002693 putative hydratase; Provisional; Region: PRK11413 198214002694 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 198214002695 substrate binding site [chemical binding]; other site 198214002696 ligand binding site [chemical binding]; other site 198214002697 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 198214002698 substrate binding site [chemical binding]; other site 198214002699 acyl-CoA thioesterase; Provisional; Region: PRK10531 198214002700 Pectinesterase; Region: Pectinesterase; cl01911 198214002701 putative transposase OrfB; Reviewed; Region: PHA02517 198214002702 HTH-like domain; Region: HTH_21; pfam13276 198214002703 Integrase core domain; Region: rve; pfam00665 198214002704 Integrase core domain; Region: rve_3; pfam13683 198214002705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002706 Transposase; Region: HTH_Tnp_1; pfam01527 198214002707 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 198214002708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214002709 FeS/SAM binding site; other site 198214002710 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 198214002711 Pyruvate formate lyase 1; Region: PFL1; cd01678 198214002712 coenzyme A binding site [chemical binding]; other site 198214002713 active site 198214002714 catalytic residues [active] 198214002715 glycine loop; other site 198214002716 formate transporter; Provisional; Region: PRK10805 198214002717 uncharacterized domain; Region: TIGR00702 198214002718 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 198214002719 homodimer interface [polypeptide binding]; other site 198214002720 substrate-cofactor binding pocket; other site 198214002721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214002722 catalytic residue [active] 198214002723 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 198214002724 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 198214002725 hinge; other site 198214002726 active site 198214002727 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214002728 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214002729 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214002730 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 198214002731 cytidylate kinase; Provisional; Region: cmk; PRK00023 198214002732 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 198214002733 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 198214002734 active site 198214002735 CMP-binding site; other site 198214002736 The sites determining sugar specificity; other site 198214002737 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 198214002738 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 198214002739 RNA binding site [nucleotide binding]; other site 198214002740 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 198214002741 RNA binding site [nucleotide binding]; other site 198214002742 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 198214002743 RNA binding site [nucleotide binding]; other site 198214002744 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 198214002745 RNA binding site [nucleotide binding]; other site 198214002746 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 198214002747 RNA binding site [nucleotide binding]; other site 198214002748 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 198214002749 RNA binding site [nucleotide binding]; other site 198214002750 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 198214002751 dimer interface [polypeptide binding]; other site 198214002752 DNA binding site [nucleotide binding] 198214002753 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787142 (781 aa). BLAST with identity of 98% in 779 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214002754 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 198214002755 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198214002756 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 198214002757 Walker A/P-loop; other site 198214002758 ATP binding site [chemical binding]; other site 198214002759 Q-loop/lid; other site 198214002760 ABC transporter signature motif; other site 198214002761 Walker B; other site 198214002762 D-loop; other site 198214002763 H-loop/switch region; other site 198214002764 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 198214002765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 198214002766 hypothetical protein; Provisional; Region: PRK11827 198214002767 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 198214002768 Ligand binding site; other site 198214002769 oligomer interface; other site 198214002770 hypothetical protein; Provisional; Region: PRK10593 198214002771 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198214002772 putative active site [active] 198214002773 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198214002774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214002775 S-adenosylmethionine binding site [chemical binding]; other site 198214002776 condesin subunit F; Provisional; Region: PRK05260 198214002777 condesin subunit E; Provisional; Region: PRK05256 198214002778 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 198214002779 MukB N-terminal; Region: MukB; pfam04310 198214002780 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 198214002781 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214002782 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214002783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214002784 murein L,D-transpeptidase; Provisional; Region: PRK10594 198214002785 K+ potassium transporter; Region: K_trans; cl15781 198214002786 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198214002787 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198214002788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 198214002789 Peptidase M15; Region: Peptidase_M15_3; cl01194 198214002790 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198214002791 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 198214002792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214002793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214002794 homodimer interface [polypeptide binding]; other site 198214002795 catalytic residue [active] 198214002796 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198214002797 trimer interface [polypeptide binding]; other site 198214002798 eyelet of channel; other site 198214002799 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 198214002800 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 198214002801 putative dimer interface [polypeptide binding]; other site 198214002802 putative anticodon binding site; other site 198214002803 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 198214002804 homodimer interface [polypeptide binding]; other site 198214002805 motif 1; other site 198214002806 motif 2; other site 198214002807 active site 198214002808 motif 3; other site 198214002809 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 198214002810 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 198214002811 active site 198214002812 aminopeptidase N; Provisional; Region: pepN; PRK14015 198214002813 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 198214002814 active site 198214002815 Zn binding site [ion binding]; other site 198214002816 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 198214002817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214002818 Walker A/P-loop; other site 198214002819 ATP binding site [chemical binding]; other site 198214002820 Q-loop/lid; other site 198214002821 ABC transporter signature motif; other site 198214002822 Walker B; other site 198214002823 D-loop; other site 198214002824 H-loop/switch region; other site 198214002825 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198214002826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214002827 dimer interface [polypeptide binding]; other site 198214002828 conserved gate region; other site 198214002829 putative PBP binding loops; other site 198214002830 ABC-ATPase subunit interface; other site 198214002831 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214002832 HTH-like domain; Region: HTH_21; pfam13276 198214002833 Integrase core domain; Region: rve; pfam00665 198214002834 Integrase core domain; Region: rve_3; pfam13683 198214002835 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214002836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002837 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 198214002838 active site 198214002839 dimer interface [polypeptide binding]; other site 198214002840 non-prolyl cis peptide bond; other site 198214002841 insertion regions; other site 198214002842 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214002843 substrate binding pocket [chemical binding]; other site 198214002844 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198214002845 membrane-bound complex binding site; other site 198214002846 hinge residues; other site 198214002847 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 198214002848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214002849 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214002850 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214002851 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214002852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214002853 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214002854 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214002855 outer membrane usher protein; Provisional; Region: PRK15193 198214002856 PapC N-terminal domain; Region: PapC_N; pfam13954 198214002857 Outer membrane usher protein; Region: Usher; pfam00577 198214002858 PapC C-terminal domain; Region: PapC_C; pfam13953 198214002859 Fimbrial protein; Region: Fimbrial; cl01416 198214002860 Fimbrial protein; Region: Fimbrial; cl01416 198214002861 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198214002862 putativi pili assembly chaperone; Provisional; Region: PRK11385 198214002863 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 198214002864 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 198214002865 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 198214002866 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 198214002867 quinone interaction residues [chemical binding]; other site 198214002868 active site 198214002869 catalytic residues [active] 198214002870 FMN binding site [chemical binding]; other site 198214002871 substrate binding site [chemical binding]; other site 198214002872 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 198214002873 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 198214002874 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 198214002875 MOSC domain; Region: MOSC; pfam03473 198214002876 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198214002877 catalytic loop [active] 198214002878 iron binding site [ion binding]; other site 198214002879 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 198214002880 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 198214002881 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 198214002882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214002883 S-adenosylmethionine binding site [chemical binding]; other site 198214002884 ABC transporter ATPase component; Reviewed; Region: PRK11147 198214002885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214002886 ABC transporter; Region: ABC_tran_2; pfam12848 198214002887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214002888 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 198214002889 Paraquat-inducible protein A; Region: PqiA; pfam04403 198214002890 Paraquat-inducible protein A; Region: PqiA; pfam04403 198214002891 paraquat-inducible protein B; Provisional; Region: PRK10807 198214002892 mce related protein; Region: MCE; pfam02470 198214002893 mce related protein; Region: MCE; pfam02470 198214002894 mce related protein; Region: MCE; pfam02470 198214002895 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 198214002896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 198214002897 Ribosome modulation factor; Region: RMF; pfam04957 198214002898 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 198214002899 active site 1 [active] 198214002900 dimer interface [polypeptide binding]; other site 198214002901 active site 2 [active] 198214002902 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 198214002903 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198214002904 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 198214002905 outer membrane protein A; Reviewed; Region: PRK10808 198214002906 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 198214002907 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198214002908 ligand binding site [chemical binding]; other site 198214002909 cell division inhibitor SulA; Region: sula; TIGR00623 198214002910 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787193 (210 aa). BLAST with identity of 99% in 137 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214002911 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214002912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214002913 TIGR01666 family membrane protein; Region: YCCS 198214002914 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 198214002915 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198214002916 Predicted membrane protein [Function unknown]; Region: COG3304 198214002917 Domain of unknown function (DUF307); Region: DUF307; pfam03733 198214002918 Domain of unknown function (DUF307); Region: DUF307; pfam03733 198214002919 DNA helicase IV; Provisional; Region: helD; PRK11054 198214002920 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 198214002921 Part of AAA domain; Region: AAA_19; pfam13245 198214002922 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198214002923 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 198214002924 active site 198214002925 dimer interfaces [polypeptide binding]; other site 198214002926 catalytic residues [active] 198214002927 hypothetical protein; Provisional; Region: PRK03641 198214002928 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 198214002929 heat shock protein HspQ; Provisional; Region: PRK14129 198214002930 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 198214002931 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 198214002932 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 198214002933 putative RNA binding site [nucleotide binding]; other site 198214002934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214002935 S-adenosylmethionine binding site [chemical binding]; other site 198214002936 Acylphosphatase; Region: Acylphosphatase; cl00551 198214002937 sulfur transfer protein TusE; Provisional; Region: PRK11508 198214002938 YccA-like proteins; Region: YccA_like; cd10433 198214002939 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 198214002940 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 198214002941 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 198214002942 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 198214002943 hydrogenase 1 large subunit; Provisional; Region: PRK10170 198214002944 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 198214002945 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 198214002946 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 198214002947 putative substrate-binding site; other site 198214002948 nickel binding site [ion binding]; other site 198214002949 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 198214002950 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 198214002951 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 198214002952 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 198214002953 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 198214002954 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198214002955 catalytic core [active] 198214002956 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 198214002957 Chain length determinant protein; Region: Wzz; pfam02706 198214002958 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198214002959 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 198214002960 AAA domain; Region: AAA_31; pfam13614 198214002961 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198214002962 active site 198214002963 polysaccharide export protein Wza; Provisional; Region: PRK15078 198214002964 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 198214002965 SLBB domain; Region: SLBB; pfam10531 198214002966 SLBB domain; Region: SLBB; pfam10531 198214002967 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 198214002968 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 198214002969 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 198214002970 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198214002971 DNA-binding site [nucleotide binding]; DNA binding site 198214002972 RNA-binding motif; other site 198214002973 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198214002974 DNA-binding site [nucleotide binding]; DNA binding site 198214002975 RNA-binding motif; other site 198214002976 cold shock gene; Provisional; Region: PRK09891 198214002977 GnsA/GnsB family; Region: GnsAB; pfam08178 198214002978 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 198214002979 4Fe-4S binding domain; Region: Fer4_5; pfam12801 198214002980 4Fe-4S binding domain; Region: Fer4_5; pfam12801 198214002981 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214002982 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 198214002983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214002984 dimerization interface [polypeptide binding]; other site 198214002985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214002986 dimer interface [polypeptide binding]; other site 198214002987 phosphorylation site [posttranslational modification] 198214002988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214002989 ATP binding site [chemical binding]; other site 198214002990 Mg2+ binding site [ion binding]; other site 198214002991 G-X-G motif; other site 198214002992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214002993 active site 198214002994 phosphorylation site [posttranslational modification] 198214002995 intermolecular recognition site; other site 198214002996 dimerization interface [polypeptide binding]; other site 198214002997 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198214002998 putative binding surface; other site 198214002999 active site 198214003000 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 198214003001 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 198214003002 putative ligand binding site [chemical binding]; other site 198214003003 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 198214003004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214003005 active site 198214003006 phosphorylation site [posttranslational modification] 198214003007 intermolecular recognition site; other site 198214003008 dimerization interface [polypeptide binding]; other site 198214003009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214003010 DNA binding site [nucleotide binding] 198214003011 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 198214003012 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 198214003013 Similar to Escherichia coli K12 trimethylamine N-oxide reductase subunit gi: 1787231 (849 aa). BLAST with identity of 98% in 847 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003014 Similar to Escherichia coli K12 part of trimethylamine-N-oxide oxidoreductase gi: 1787232 (200 aa). BLAST with identity of 97% in 459 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214003015 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214003016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214003017 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214003018 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214003019 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 198214003020 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 198214003021 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198214003022 HSP70 interaction site [polypeptide binding]; other site 198214003023 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 198214003024 substrate binding site [polypeptide binding]; other site 198214003025 dimer interface [polypeptide binding]; other site 198214003026 hypothetical protein; Provisional; Region: PRK09784 198214003027 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198214003028 catalytic core [active] 198214003029 hypothetical protein; Provisional; Region: PRK10174 198214003030 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 198214003031 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 198214003032 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 198214003033 uracil-xanthine permease; Region: ncs2; TIGR00801 198214003034 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 198214003035 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 198214003036 putative FMN binding site [chemical binding]; other site 198214003037 pyrimidine utilization protein D; Region: RutD; TIGR03611 198214003038 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198214003039 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198214003040 homotrimer interaction site [polypeptide binding]; other site 198214003041 putative active site [active] 198214003042 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 198214003043 catalytic triad [active] 198214003044 conserved cis-peptide bond; other site 198214003045 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 198214003046 active site 198214003047 dimer interface [polypeptide binding]; other site 198214003048 non-prolyl cis peptide bond; other site 198214003049 insertion regions; other site 198214003050 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 198214003051 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 198214003052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214003053 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 198214003054 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214003055 Putative transposase; Region: Y2_Tnp; pfam04986 198214003056 Iron permease FTR1 family; Region: FTR1; cl00475 198214003057 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 198214003058 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 198214003059 Imelysin; Region: Peptidase_M75; pfam09375 198214003060 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 198214003061 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 198214003062 hypothetical protein; Provisional; Region: PRK10536 198214003063 putative transposase OrfB; Reviewed; Region: PHA02517 198214003064 HTH-like domain; Region: HTH_21; pfam13276 198214003065 Integrase core domain; Region: rve; pfam00665 198214003066 Integrase core domain; Region: rve_2; pfam13333 198214003067 Transposase; Region: HTH_Tnp_1; cl17663 198214003068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003069 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787266 (108 aa). BLAST with identity of 99% in 108 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214003070 Similar to Escherichia coli K12 dehydrogenase gi: 1787270 (326 aa). BLAST with identity of 99% in 326 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003071 putative hydrolase; Validated; Region: PRK09248 198214003072 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 198214003073 active site 198214003074 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 198214003075 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 198214003076 'Similar to Escherichia coli K12 curli production assembly/transport component, 2nd curli operon gi: 1787274 (278 aa). BLAST with identity of 97% in 257 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214003077 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214003078 curli assembly protein CsgE; Provisional; Region: PRK10386 198214003079 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 198214003080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214003081 DNA binding residues [nucleotide binding] 198214003082 dimerization interface [polypeptide binding]; other site 198214003083 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 198214003084 Curlin associated repeat; Region: Curlin_rpt; pfam07012 198214003085 Curlin associated repeat; Region: Curlin_rpt; pfam07012 198214003086 'Similar to Escherichia coli K12 curlin major subunit, coiled surface structures; cryptic gi: 1787279 (152 aa). BLAST with identity of 98% in 532 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct.' 198214003087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003088 Transposase; Region: HTH_Tnp_1; pfam01527 198214003089 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 198214003090 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198214003091 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 198214003092 putative ADP-ribose binding site [chemical binding]; other site 198214003093 putative active site [active] 198214003094 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 198214003095 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 198214003096 putative active site [active] 198214003097 catalytic site [active] 198214003098 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 198214003099 putative active site [active] 198214003100 catalytic site [active] 198214003101 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 198214003102 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 198214003103 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 198214003104 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 198214003105 Ligand binding site; other site 198214003106 DXD motif; other site 198214003107 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214003108 Putative transposase; Region: Y2_Tnp; pfam04986 198214003109 Transposase; Region: HTH_Tnp_1; cl17663 198214003110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003112 Transposase; Region: HTH_Tnp_1; cl17663 198214003113 putative transposase OrfB; Reviewed; Region: PHA02517 198214003114 HTH-like domain; Region: HTH_21; pfam13276 198214003115 Integrase core domain; Region: rve; pfam00665 198214003116 Integrase core domain; Region: rve_3; pfam13683 198214003117 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214003118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003119 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214003120 HTH-like domain; Region: HTH_21; pfam13276 198214003121 Integrase core domain; Region: rve; pfam00665 198214003122 Integrase core domain; Region: rve_3; pfam13683 198214003123 Transposase; Region: HTH_Tnp_1; cl17663 198214003124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003126 Transposase; Region: HTH_Tnp_1; pfam01527 198214003127 putative transposase OrfB; Reviewed; Region: PHA02517 198214003128 HTH-like domain; Region: HTH_21; pfam13276 198214003129 Integrase core domain; Region: rve; pfam00665 198214003130 Integrase core domain; Region: rve_3; pfam13683 198214003131 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 198214003132 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 198214003133 catalytic residues [active] 198214003134 catalytic nucleophile [active] 198214003135 Recombinase; Region: Recombinase; pfam07508 198214003136 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198214003137 putative acyl-acceptor binding pocket; other site 198214003138 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 198214003139 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 198214003140 active site residue [active] 198214003141 hypothetical protein; Provisional; Region: PRK03757 198214003142 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 198214003143 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 198214003144 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 198214003145 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 198214003146 DNA damage-inducible protein I; Provisional; Region: PRK10597 198214003147 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 198214003148 active site 198214003149 substrate binding pocket [chemical binding]; other site 198214003150 dimer interface [polypeptide binding]; other site 198214003151 lipoprotein; Provisional; Region: PRK10598 198214003152 glutaredoxin 2; Provisional; Region: PRK10387 198214003153 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 198214003154 C-terminal domain interface [polypeptide binding]; other site 198214003155 GSH binding site (G-site) [chemical binding]; other site 198214003156 catalytic residues [active] 198214003157 putative dimer interface [polypeptide binding]; other site 198214003158 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 198214003159 N-terminal domain interface [polypeptide binding]; other site 198214003160 multidrug resistance protein MdtH; Provisional; Region: PRK11646 198214003161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214003162 putative substrate translocation pore; other site 198214003163 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 198214003164 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198214003165 hypothetical protein; Provisional; Region: PRK11239 198214003166 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 198214003167 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 198214003168 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 198214003169 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 198214003170 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 198214003171 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 198214003172 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 198214003173 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 198214003174 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 198214003175 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 198214003176 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 198214003177 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 198214003178 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198214003179 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 198214003180 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198214003181 'Similar to Escherichia coli K12 flagellar biosynthesis, cell-proximal portion of basal-body rod gi: 1787317 (252 aa). BLAST with identity of 96% in 251 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214003182 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 198214003183 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198214003184 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198214003185 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 198214003186 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 198214003187 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 198214003188 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 198214003189 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 198214003190 'Similar to Escherichia coli K12 flagellar biosynthesis, hook-filament junction protein 1 gi: 1787323 (548 aa). BLAST with identity of 98% in 548 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214003191 Similar to Escherichia coli K12 flagellar biosynthesis; hook-filament junction protein gi: 1787324 (318 aa). BLAST with identity of 94% in 314 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003192 ribonuclease E; Reviewed; Region: rne; PRK10811 198214003193 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 198214003194 homodimer interface [polypeptide binding]; other site 198214003195 oligonucleotide binding site [chemical binding]; other site 198214003196 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 198214003197 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 198214003198 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 198214003199 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 198214003200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214003201 RNA binding surface [nucleotide binding]; other site 198214003202 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198214003203 active site 198214003204 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 198214003205 active site 198214003206 dimer interface [polypeptide binding]; other site 198214003207 hypothetical protein; Provisional; Region: PRK11193 198214003208 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 198214003209 putative phosphate acyltransferase; Provisional; Region: PRK05331 198214003210 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 198214003211 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 198214003212 dimer interface [polypeptide binding]; other site 198214003213 active site 198214003214 CoA binding pocket [chemical binding]; other site 198214003215 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 198214003216 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 198214003217 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 198214003218 NAD(P) binding site [chemical binding]; other site 198214003219 homotetramer interface [polypeptide binding]; other site 198214003220 homodimer interface [polypeptide binding]; other site 198214003221 active site 198214003222 acyl carrier protein; Provisional; Region: acpP; PRK00982 198214003223 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 198214003224 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198214003225 dimer interface [polypeptide binding]; other site 198214003226 active site 198214003227 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 198214003228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214003229 catalytic residue [active] 198214003230 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 198214003231 dimerization interface [polypeptide binding]; other site 198214003232 thymidylate kinase; Validated; Region: tmk; PRK00698 198214003233 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198214003234 TMP-binding site; other site 198214003235 ATP-binding site [chemical binding]; other site 198214003236 DNA polymerase III subunit delta'; Validated; Region: PRK07993 198214003237 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 198214003238 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198214003239 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 198214003240 active site 198214003241 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 198214003242 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198214003243 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198214003244 active site turn [active] 198214003245 phosphorylation site [posttranslational modification] 198214003246 Similar to Escherichia coli K12 outer membrane receptor for ferric iron uptake gi: 1787344 (730 aa). BLAST with identity of 99% in 728 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003247 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 198214003248 nucleotide binding site/active site [active] 198214003249 HIT family signature motif; other site 198214003250 catalytic residue [active] 198214003251 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 198214003252 putative dimer interface [polypeptide binding]; other site 198214003253 Phosphotransferase enzyme family; Region: APH; pfam01636 198214003254 active site 198214003255 substrate binding site [chemical binding]; other site 198214003256 ATP binding site [chemical binding]; other site 198214003257 thiamine kinase; Provisional; Region: thiK; PRK10271 198214003258 beta-hexosaminidase; Provisional; Region: PRK05337 198214003259 hypothetical protein; Provisional; Region: PRK04940 198214003260 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 198214003261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214003262 hypothetical protein; Provisional; Region: PRK11280 198214003263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198214003264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214003265 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198214003266 L,D-transpeptidase; Provisional; Region: PRK10260 198214003267 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214003268 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198214003269 transcription-repair coupling factor; Provisional; Region: PRK10689 198214003270 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 198214003271 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 198214003272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214003273 ATP binding site [chemical binding]; other site 198214003274 putative Mg++ binding site [ion binding]; other site 198214003275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214003276 nucleotide binding region [chemical binding]; other site 198214003277 ATP-binding site [chemical binding]; other site 198214003278 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 198214003279 Predicted membrane protein [Function unknown]; Region: COG4763 198214003280 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 198214003281 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198214003282 FtsX-like permease family; Region: FtsX; pfam02687 198214003283 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 198214003284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198214003285 Walker A/P-loop; other site 198214003286 ATP binding site [chemical binding]; other site 198214003287 Q-loop/lid; other site 198214003288 ABC transporter signature motif; other site 198214003289 Walker B; other site 198214003290 D-loop; other site 198214003291 H-loop/switch region; other site 198214003292 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 198214003293 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198214003294 FtsX-like permease family; Region: FtsX; pfam02687 198214003295 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198214003296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214003297 nucleotide binding site [chemical binding]; other site 198214003298 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 198214003299 NAD+ binding site [chemical binding]; other site 198214003300 substrate binding site [chemical binding]; other site 198214003301 Zn binding site [ion binding]; other site 198214003302 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 198214003303 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 198214003304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003305 dimer interface [polypeptide binding]; other site 198214003306 conserved gate region; other site 198214003307 putative PBP binding loops; other site 198214003308 ABC-ATPase subunit interface; other site 198214003309 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198214003310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003311 dimer interface [polypeptide binding]; other site 198214003312 conserved gate region; other site 198214003313 putative PBP binding loops; other site 198214003314 ABC-ATPase subunit interface; other site 198214003315 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 198214003316 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 198214003317 Walker A/P-loop; other site 198214003318 ATP binding site [chemical binding]; other site 198214003319 Q-loop/lid; other site 198214003320 ABC transporter signature motif; other site 198214003321 Walker B; other site 198214003322 D-loop; other site 198214003323 H-loop/switch region; other site 198214003324 TOBE domain; Region: TOBE_2; pfam08402 198214003325 peptidase T-like protein; Region: PepT-like; TIGR01883 198214003326 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 198214003327 metal binding site [ion binding]; metal-binding site 198214003328 dimer interface [polypeptide binding]; other site 198214003329 Uncharacterized conserved protein [Function unknown]; Region: COG2850 198214003330 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 198214003331 D5 N terminal like; Region: D5_N; smart00885 198214003332 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 198214003333 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 198214003334 Similar to Escherichia coli O157:H7 EDL933 capsid protein of prophage CP-933C ref: NP_287332.1 (385 aa). BLAST with identity of 98% in 402 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003335 Phage head maturation protease [General function prediction only]; Region: COG3740 198214003336 Phage-related protein [Function unknown]; Region: COG4695 198214003337 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 198214003338 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 198214003339 oligomerization interface [polypeptide binding]; other site 198214003340 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198214003341 active site 198214003342 Phage terminase, small subunit; Region: Terminase_4; cl01525 198214003343 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 198214003344 Phage Terminase; Region: Terminase_1; cl19862 198214003345 sensor protein PhoQ; Provisional; Region: PRK10815 198214003346 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 198214003347 HAMP domain; Region: HAMP; pfam00672 198214003348 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 198214003349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214003350 ATP binding site [chemical binding]; other site 198214003351 Mg2+ binding site [ion binding]; other site 198214003352 G-X-G motif; other site 198214003353 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 198214003354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214003355 active site 198214003356 phosphorylation site [posttranslational modification] 198214003357 intermolecular recognition site; other site 198214003358 dimerization interface [polypeptide binding]; other site 198214003359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214003360 DNA binding site [nucleotide binding] 198214003361 adenylosuccinate lyase; Provisional; Region: PRK09285 198214003362 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 198214003363 tetramer interface [polypeptide binding]; other site 198214003364 active site 198214003365 putative lysogenization regulator; Reviewed; Region: PRK00218 198214003366 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 198214003367 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 198214003368 Ligand Binding Site [chemical binding]; other site 198214003369 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 198214003370 nudix motif; other site 198214003371 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 198214003372 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 198214003373 probable active site [active] 198214003374 isocitrate dehydrogenase; Reviewed; Region: PRK07006 198214003375 phage resistance protein; Provisional; Region: PRK10551 198214003376 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198214003377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198214003378 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 198214003379 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 198214003380 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214003381 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198214003382 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 198214003383 Autotransporter beta-domain; Region: Autotransporter; smart00869 198214003384 Similar to Escherichia coli O157:H7 ATP-binding component of a transport system ref: NP_311542.1 (1571 aa). BLAST with identity of 96% in 136 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214003385 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 198214003386 cell division inhibitor MinD; Provisional; Region: PRK10818 198214003387 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 198214003388 P-loop; other site 198214003389 ADP binding residues [chemical binding]; other site 198214003390 Switch I; other site 198214003391 Switch II; other site 198214003392 septum formation inhibitor; Reviewed; Region: minC; PRK03511 198214003393 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 198214003394 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 198214003395 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214003396 HTH-like domain; Region: HTH_21; pfam13276 198214003397 Integrase core domain; Region: rve; pfam00665 198214003398 Integrase core domain; Region: rve_3; pfam13683 198214003399 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214003400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003401 Transposase; Region: HTH_Tnp_1; cl17663 198214003402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003403 putative transposase OrfB; Reviewed; Region: PHA02517 198214003404 HTH-like domain; Region: HTH_21; pfam13276 198214003405 Integrase core domain; Region: rve; pfam00665 198214003406 Integrase core domain; Region: rve_2; pfam13333 198214003407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 198214003408 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 198214003409 hypothetical protein; Provisional; Region: PRK10691 198214003410 hypothetical protein; Provisional; Region: PRK05170 198214003411 Similar to Escherichia coli K12 hemolysin E gi: 1787430 (306 aa). BLAST with identity of 98% in 302 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003412 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 198214003413 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 198214003414 Catalytic site [active] 198214003415 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 198214003416 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 198214003417 active site 198214003418 DNA binding site [nucleotide binding] 198214003419 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 198214003420 disulfide bond formation protein B; Provisional; Region: PRK01749 198214003421 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 198214003422 fatty acid metabolism regulator; Provisional; Region: PRK04984 198214003423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214003424 DNA-binding site [nucleotide binding]; DNA binding site 198214003425 FadR C-terminal domain; Region: FadR_C; pfam07840 198214003426 SpoVR family protein; Provisional; Region: PRK11767 198214003427 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 198214003428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214003429 alanine racemase; Reviewed; Region: dadX; PRK03646 198214003430 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 198214003431 active site 198214003432 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198214003433 substrate binding site [chemical binding]; other site 198214003434 catalytic residues [active] 198214003435 dimer interface [polypeptide binding]; other site 198214003436 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 198214003437 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 198214003438 TrkA-C domain; Region: TrkA_C; pfam02080 198214003439 Transporter associated domain; Region: CorC_HlyC; smart01091 198214003440 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 198214003441 dimer interface [polypeptide binding]; other site 198214003442 catalytic triad [active] 198214003443 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214003444 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214003445 catalytic residue [active] 198214003446 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 198214003447 Flagellar regulator YcgR; Region: YcgR; pfam07317 198214003448 PilZ domain; Region: PilZ; pfam07238 198214003449 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 198214003450 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214003451 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214003452 catalytic residue [active] 198214003453 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 198214003454 Flagellar regulator YcgR; Region: YcgR; pfam07317 198214003455 PilZ domain; Region: PilZ; pfam07238 198214003456 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 198214003457 'Similar to Escherichia coli O157:H7 EDL933 outer membrane receptor, probably tonB dependent ref: NP_287437.1 (656 aa). BLAST with identity of 98% in 659 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214003458 molybdenum transport protein ModD; Provisional; Region: PRK06096 198214003459 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 198214003460 dimerization interface [polypeptide binding]; other site 198214003461 active site 198214003462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214003463 S-adenosylmethionine binding site [chemical binding]; other site 198214003464 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198214003465 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198214003466 Walker A/P-loop; other site 198214003467 ATP binding site [chemical binding]; other site 198214003468 Q-loop/lid; other site 198214003469 ABC transporter signature motif; other site 198214003470 Walker B; other site 198214003471 D-loop; other site 198214003472 H-loop/switch region; other site 198214003473 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214003474 ABC-ATPase subunit interface; other site 198214003475 dimer interface [polypeptide binding]; other site 198214003476 putative PBP binding regions; other site 198214003477 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 198214003478 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 198214003479 putative metal binding site [ion binding]; other site 198214003480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214003481 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214003482 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214003483 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214003484 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787446 (147 aa). BLAST with identity of 99% in 147 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214003485 trehalase; Provisional; Region: treA; PRK13271 198214003486 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 198214003487 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 198214003488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 198214003489 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198214003490 dimerization domain swap beta strand [polypeptide binding]; other site 198214003491 regulatory protein interface [polypeptide binding]; other site 198214003492 active site 198214003493 regulatory phosphorylation site [posttranslational modification]; other site 198214003494 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 198214003495 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198214003496 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 198214003497 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 198214003498 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 198214003499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198214003500 putative active site [active] 198214003501 heme pocket [chemical binding]; other site 198214003502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214003503 Walker A motif; other site 198214003504 ATP binding site [chemical binding]; other site 198214003505 Walker B motif; other site 198214003506 arginine finger; other site 198214003507 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198214003508 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198214003509 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214003510 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198214003511 GTP-binding protein YchF; Reviewed; Region: PRK09601 198214003512 YchF GTPase; Region: YchF; cd01900 198214003513 G1 box; other site 198214003514 GTP/Mg2+ binding site [chemical binding]; other site 198214003515 Switch I region; other site 198214003516 G2 box; other site 198214003517 Switch II region; other site 198214003518 G3 box; other site 198214003519 G4 box; other site 198214003520 G5 box; other site 198214003521 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 198214003522 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 198214003523 putative active site [active] 198214003524 catalytic residue [active] 198214003525 hypothetical protein; Provisional; Region: PRK10692 198214003526 putative transporter; Provisional; Region: PRK11660 198214003527 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 198214003528 Sulfate transporter family; Region: Sulfate_transp; pfam00916 198214003529 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 198214003530 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 198214003531 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 198214003532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214003533 active site 198214003534 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 198214003535 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198214003536 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 198214003537 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 198214003538 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 198214003539 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 198214003540 tRNA; other site 198214003541 putative tRNA binding site [nucleotide binding]; other site 198214003542 putative NADP binding site [chemical binding]; other site 198214003543 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 198214003544 peptide chain release factor 1; Validated; Region: prfA; PRK00591 198214003545 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198214003546 RF-1 domain; Region: RF-1; pfam00472 198214003547 HemK family putative methylases; Region: hemK_fam; TIGR00536 198214003548 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 198214003549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214003550 S-adenosylmethionine binding site [chemical binding]; other site 198214003551 hypothetical protein; Provisional; Region: PRK10278 198214003552 hypothetical protein; Provisional; Region: PRK10941 198214003553 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 198214003554 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 198214003555 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 198214003556 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 198214003557 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198214003558 cation transport regulator; Reviewed; Region: chaB; PRK09582 198214003559 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 198214003560 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 198214003561 putative active site pocket [active] 198214003562 dimerization interface [polypeptide binding]; other site 198214003563 putative catalytic residue [active] 198214003564 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 198214003565 putative invasin; Provisional; Region: PRK10177 198214003566 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 198214003567 transcriptional regulator NarL; Provisional; Region: PRK10651 198214003568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214003569 active site 198214003570 phosphorylation site [posttranslational modification] 198214003571 intermolecular recognition site; other site 198214003572 dimerization interface [polypeptide binding]; other site 198214003573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214003574 DNA binding residues [nucleotide binding] 198214003575 dimerization interface [polypeptide binding]; other site 198214003576 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 198214003577 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 198214003578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214003579 dimerization interface [polypeptide binding]; other site 198214003580 Histidine kinase; Region: HisKA_3; pfam07730 198214003581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214003582 ATP binding site [chemical binding]; other site 198214003583 Mg2+ binding site [ion binding]; other site 198214003584 G-X-G motif; other site 198214003585 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 198214003586 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 198214003587 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 198214003588 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 198214003589 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 198214003590 [4Fe-4S] binding site [ion binding]; other site 198214003591 molybdopterin cofactor binding site [chemical binding]; other site 198214003592 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 198214003593 molybdopterin cofactor binding site; other site 198214003594 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 198214003595 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214003596 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 198214003597 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 198214003598 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 198214003599 potential protein location (hypothetical protein SF1231 [Shigella flexneri 2a str. 301]) that overlaps RNA (tRNA-Y) 198214003600 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 198214003601 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 198214003602 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 198214003603 putative active site [active] 198214003604 putative substrate binding site [chemical binding]; other site 198214003605 putative cosubstrate binding site; other site 198214003606 catalytic site [active] 198214003607 hypothetical protein; Provisional; Region: PRK01617 198214003608 SEC-C motif; Region: SEC-C; cl19389 198214003609 SEC-C motif; Region: SEC-C; cl19389 198214003610 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 198214003611 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 198214003612 active site 198214003613 nucleophile elbow; other site 198214003614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214003615 active site 198214003616 response regulator of RpoS; Provisional; Region: PRK10693 198214003617 phosphorylation site [posttranslational modification] 198214003618 intermolecular recognition site; other site 198214003619 dimerization interface [polypeptide binding]; other site 198214003620 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 198214003621 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 198214003622 active site 198214003623 tetramer interface; other site 198214003624 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 198214003625 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 198214003626 thymidine kinase; Provisional; Region: PRK04296 198214003627 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214003628 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214003629 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214003630 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 198214003631 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 198214003632 putative catalytic cysteine [active] 198214003633 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 198214003634 putative active site [active] 198214003635 metal binding site [ion binding]; metal-binding site 198214003636 hypothetical protein; Provisional; Region: PRK11111 198214003637 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214003638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214003639 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214003640 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214003641 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198214003642 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198214003643 peptide binding site [polypeptide binding]; other site 198214003644 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 198214003645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003646 dimer interface [polypeptide binding]; other site 198214003647 conserved gate region; other site 198214003648 putative PBP binding loops; other site 198214003649 ABC-ATPase subunit interface; other site 198214003650 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 198214003651 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198214003652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003653 dimer interface [polypeptide binding]; other site 198214003654 conserved gate region; other site 198214003655 putative PBP binding loops; other site 198214003656 ABC-ATPase subunit interface; other site 198214003657 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 198214003658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214003659 Walker A/P-loop; other site 198214003660 ATP binding site [chemical binding]; other site 198214003661 Q-loop/lid; other site 198214003662 ABC transporter signature motif; other site 198214003663 Walker B; other site 198214003664 D-loop; other site 198214003665 H-loop/switch region; other site 198214003666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214003667 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 198214003668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214003669 Walker A/P-loop; other site 198214003670 ATP binding site [chemical binding]; other site 198214003671 Q-loop/lid; other site 198214003672 ABC transporter signature motif; other site 198214003673 Walker B; other site 198214003674 D-loop; other site 198214003675 H-loop/switch region; other site 198214003676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214003677 dsDNA-mimic protein; Reviewed; Region: PRK05094 198214003678 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 198214003679 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 198214003680 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 198214003681 putative active site [active] 198214003682 catalytic site [active] 198214003683 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 198214003684 putative active site [active] 198214003685 catalytic site [active] 198214003686 voltage-gated potassium channel; Provisional; Region: PRK10537 198214003687 Ion channel; Region: Ion_trans_2; pfam07885 198214003688 TrkA-N domain; Region: TrkA_N; pfam02254 198214003689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003690 Transposase; Region: HTH_Tnp_1; pfam01527 198214003691 HTH-like domain; Region: HTH_21; pfam13276 198214003692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198214003693 Integrase core domain; Region: rve; pfam00665 198214003694 Integrase core domain; Region: rve_3; pfam13683 198214003695 YciI-like protein; Reviewed; Region: PRK11370 198214003696 transport protein TonB; Provisional; Region: PRK10819 198214003697 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 198214003698 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 198214003699 intracellular septation protein A; Reviewed; Region: PRK00259 198214003700 hypothetical protein; Provisional; Region: PRK02868 198214003701 outer membrane protein W; Provisional; Region: PRK10959 198214003702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 198214003703 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 198214003704 dimerization interface [polypeptide binding]; other site 198214003705 metal binding site [ion binding]; metal-binding site 198214003706 General stress protein [General function prediction only]; Region: GsiB; COG3729 198214003707 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 198214003708 substrate binding site [chemical binding]; other site 198214003709 active site 198214003710 catalytic residues [active] 198214003711 heterodimer interface [polypeptide binding]; other site 198214003712 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 198214003713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214003714 catalytic residue [active] 198214003715 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 198214003716 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 198214003717 active site 198214003718 ribulose/triose binding site [chemical binding]; other site 198214003719 phosphate binding site [ion binding]; other site 198214003720 substrate (anthranilate) binding pocket [chemical binding]; other site 198214003721 product (indole) binding pocket [chemical binding]; other site 198214003722 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 198214003723 active site 198214003724 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 198214003725 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198214003726 glutamine binding [chemical binding]; other site 198214003727 catalytic triad [active] 198214003728 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198214003729 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198214003730 anthranilate synthase component I; Provisional; Region: PRK13564 198214003731 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198214003732 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 198214003733 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 198214003734 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 198214003735 active site 198214003736 hypothetical protein; Provisional; Region: PRK11630 198214003737 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787524 (292 aa). BLAST with identity of 98% in 279 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003738 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 198214003739 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 198214003740 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 198214003741 homodimer interface [polypeptide binding]; other site 198214003742 Walker A motif; other site 198214003743 ATP binding site [chemical binding]; other site 198214003744 hydroxycobalamin binding site [chemical binding]; other site 198214003745 Walker B motif; other site 198214003746 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 198214003747 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 198214003748 NADP binding site [chemical binding]; other site 198214003749 homodimer interface [polypeptide binding]; other site 198214003750 active site 198214003751 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 198214003752 putative inner membrane peptidase; Provisional; Region: PRK11778 198214003753 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 198214003754 tandem repeat interface [polypeptide binding]; other site 198214003755 oligomer interface [polypeptide binding]; other site 198214003756 active site residues [active] 198214003757 hypothetical protein; Provisional; Region: PRK11037 198214003758 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 198214003759 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 198214003760 active site 198214003761 interdomain interaction site; other site 198214003762 putative metal-binding site [ion binding]; other site 198214003763 nucleotide binding site [chemical binding]; other site 198214003764 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198214003765 domain I; other site 198214003766 DNA binding groove [nucleotide binding] 198214003767 phosphate binding site [ion binding]; other site 198214003768 domain II; other site 198214003769 domain III; other site 198214003770 nucleotide binding site [chemical binding]; other site 198214003771 catalytic site [active] 198214003772 domain IV; other site 198214003773 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198214003774 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198214003775 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 198214003776 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 198214003777 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 198214003778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214003779 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 198214003780 substrate binding site [chemical binding]; other site 198214003781 putative dimerization interface [polypeptide binding]; other site 198214003782 aconitate hydratase; Validated; Region: PRK09277 198214003783 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 198214003784 substrate binding site [chemical binding]; other site 198214003785 ligand binding site [chemical binding]; other site 198214003786 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 198214003787 substrate binding site [chemical binding]; other site 198214003788 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 198214003789 dimerization interface [polypeptide binding]; other site 198214003790 active site 198214003791 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198214003792 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 198214003793 active site 198214003794 Predicted membrane protein [Function unknown]; Region: COG3771 198214003795 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 198214003796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198214003797 TPR motif; other site 198214003798 binding surface 198214003799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198214003800 binding surface 198214003801 TPR motif; other site 198214003802 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 198214003803 active site 198214003804 dimer interface [polypeptide binding]; other site 198214003805 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 198214003806 putative rRNA binding site [nucleotide binding]; other site 198214003807 lipoprotein; Provisional; Region: PRK10540 198214003808 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198214003809 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198214003810 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214003811 hypothetical protein; Provisional; Region: PRK13658 198214003812 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787541 (662 aa). BLAST with identity of 98% in 658 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214003813 exoribonuclease II; Provisional; Region: PRK05054 198214003814 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198214003815 RNB domain; Region: RNB; pfam00773 198214003816 S1 RNA binding domain; Region: S1; pfam00575 198214003817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 198214003818 Uncharacterized conserved protein [Function unknown]; Region: COG2128 198214003819 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 198214003820 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 198214003821 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 198214003822 NAD binding site [chemical binding]; other site 198214003823 homotetramer interface [polypeptide binding]; other site 198214003824 homodimer interface [polypeptide binding]; other site 198214003825 substrate binding site [chemical binding]; other site 198214003826 active site 198214003827 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 198214003828 putative active site [active] 198214003829 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 198214003830 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214003831 Walker A/P-loop; other site 198214003832 ATP binding site [chemical binding]; other site 198214003833 Q-loop/lid; other site 198214003834 ABC transporter signature motif; other site 198214003835 Walker B; other site 198214003836 D-loop; other site 198214003837 H-loop/switch region; other site 198214003838 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 198214003839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214003840 Walker A/P-loop; other site 198214003841 ATP binding site [chemical binding]; other site 198214003842 Q-loop/lid; other site 198214003843 ABC transporter signature motif; other site 198214003844 Walker B; other site 198214003845 D-loop; other site 198214003846 H-loop/switch region; other site 198214003847 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214003848 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 198214003849 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198214003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003851 dimer interface [polypeptide binding]; other site 198214003852 conserved gate region; other site 198214003853 putative PBP binding loops; other site 198214003854 ABC-ATPase subunit interface; other site 198214003855 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 198214003856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003857 dimer interface [polypeptide binding]; other site 198214003858 conserved gate region; other site 198214003859 putative PBP binding loops; other site 198214003860 ABC-ATPase subunit interface; other site 198214003861 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 198214003862 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 198214003863 peptide binding site [polypeptide binding]; other site 198214003864 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 198214003865 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214003866 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198214003867 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 198214003868 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 198214003869 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 198214003870 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 198214003871 catalytic triad [active] 198214003872 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 198214003873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214003874 non-specific DNA binding site [nucleotide binding]; other site 198214003875 salt bridge; other site 198214003876 sequence-specific DNA binding site [nucleotide binding]; other site 198214003877 Cupin domain; Region: Cupin_2; pfam07883 198214003878 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 198214003879 NAD(P) binding site [chemical binding]; other site 198214003880 catalytic residues [active] 198214003881 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 198214003882 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 198214003883 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198214003884 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198214003885 inhibitor-cofactor binding pocket; inhibition site 198214003886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214003887 catalytic residue [active] 198214003888 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 198214003889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214003890 Walker A motif; other site 198214003891 ATP binding site [chemical binding]; other site 198214003892 Walker B motif; other site 198214003893 arginine finger; other site 198214003894 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 198214003895 phage shock protein PspA; Provisional; Region: PRK10698 198214003896 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 198214003897 phage shock protein B; Provisional; Region: pspB; PRK09458 198214003898 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 198214003899 phage shock protein C; Region: phageshock_pspC; TIGR02978 198214003900 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 198214003901 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198214003902 active site residue [active] 198214003903 Similar to Escherichia coli K12 polysaccharide hydrolase gi: 1787568 (569 aa). BLAST with identity of 93% in 823 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214003904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214003905 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214003906 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214003907 Similar to Escherichia coli K12 transport periplasmic protein gi: 1787569 (431 aa). BLAST with identity of 95% in 428 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003908 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 198214003909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003910 dimer interface [polypeptide binding]; other site 198214003911 conserved gate region; other site 198214003912 putative PBP binding loops; other site 198214003913 ABC-ATPase subunit interface; other site 198214003914 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198214003915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214003916 dimer interface [polypeptide binding]; other site 198214003917 conserved gate region; other site 198214003918 putative PBP binding loops; other site 198214003919 ABC-ATPase subunit interface; other site 198214003920 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198214003921 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 198214003922 putative NAD(P) binding site [chemical binding]; other site 198214003923 Similar to Escherichia coli K12 transient receptor potential locus gi: 1787573 (266 aa). BLAST with identity of 96% in 160 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003924 Similar to Escherichia coli K12 dehydrogenase gi: 1787574 (352 aa). BLAST with identity of 98% in 352 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214003925 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 198214003926 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 198214003927 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 198214003928 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 198214003929 beta-phosphoglucomutase; Region: bPGM; TIGR01990 198214003930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214003931 motif II; other site 198214003932 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 198214003933 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198214003934 Walker A/P-loop; other site 198214003935 ATP binding site [chemical binding]; other site 198214003936 Q-loop/lid; other site 198214003937 ABC transporter signature motif; other site 198214003938 Walker B; other site 198214003939 D-loop; other site 198214003940 H-loop/switch region; other site 198214003941 TOBE domain; Region: TOBE_2; pfam08402 198214003942 Similar to Escherichia coli K12 outer membrane protein gi: 1787579 (302 aa). BLAST with identity of 98% in 301 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214003943 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198214003944 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214003945 DNA binding site [nucleotide binding] 198214003946 domain linker motif; other site 198214003947 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 198214003948 putative dimerization interface [polypeptide binding]; other site 198214003949 putative ligand binding site [chemical binding]; other site 198214003950 Predicted ATPase [General function prediction only]; Region: COG3106 198214003951 hypothetical protein; Provisional; Region: PRK05415 198214003952 Predicted membrane protein [Function unknown]; Region: COG3768 198214003953 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 198214003954 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 198214003955 putative aromatic amino acid binding site; other site 198214003956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198214003957 putative active site [active] 198214003958 heme pocket [chemical binding]; other site 198214003959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214003960 Walker A motif; other site 198214003961 ATP binding site [chemical binding]; other site 198214003962 Walker B motif; other site 198214003963 arginine finger; other site 198214003964 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 198214003965 dimer interface [polypeptide binding]; other site 198214003966 catalytic triad [active] 198214003967 peroxidatic and resolving cysteines [active] 198214003968 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 198214003969 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 198214003970 active site 198214003971 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 198214003972 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 198214003973 putative active site [active] 198214003974 Zn binding site [ion binding]; other site 198214003975 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 198214003976 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 198214003977 putative NAD(P) binding site [chemical binding]; other site 198214003978 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 198214003979 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214003980 Y-family of DNA polymerases; Region: PolY; cl12025 198214003981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214003982 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214003983 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 198214003984 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198214003985 Erv1 / Alr family; Region: Evr1_Alr; cl02107 198214003986 Similar to Escherichia coli K12 transcriptional regulator LYSR-type gi: 1787589 (300 aa). BLAST with identity of 97% in 145 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214003987 putative transposase OrfB; Reviewed; Region: PHA02517 198214003988 HTH-like domain; Region: HTH_21; pfam13276 198214003989 Integrase core domain; Region: rve; pfam00665 198214003990 Integrase core domain; Region: rve_3; pfam13683 198214003991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214003992 Transposase; Region: HTH_Tnp_1; pfam01527 198214003993 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787622 (286 aa). BLAST with identity of 96% in 841 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214003994 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214003995 HTH-like domain; Region: HTH_21; pfam13276 198214003996 Integrase core domain; Region: rve; pfam00665 198214003997 Integrase core domain; Region: rve_3; pfam13683 198214003998 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214003999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004000 putative replication protein; Provisional; Region: PRK12377 198214004001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214004002 Walker A motif; other site 198214004003 ATP binding site [chemical binding]; other site 198214004004 Walker B motif; other site 198214004005 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 198214004006 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 198214004007 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198214004008 active site 198214004009 Protein of unknown function (DUF551); Region: DUF551; pfam04448 198214004010 Hok/gef family; Region: HOK_GEF; pfam01848 198214004011 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004013 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004014 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004015 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 198214004016 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 198214004017 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 198214004018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004019 Transposase; Region: HTH_Tnp_1; pfam01527 198214004020 putative transposase OrfB; Reviewed; Region: PHA02517 198214004021 HTH-like domain; Region: HTH_21; pfam13276 198214004022 Integrase core domain; Region: rve; pfam00665 198214004023 Integrase core domain; Region: rve_3; pfam13683 198214004024 ipaH island II 198214004025 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198214004026 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 198214004027 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214004028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214004029 ABC-ATPase subunit interface; other site 198214004030 dimer interface [polypeptide binding]; other site 198214004031 putative PBP binding regions; other site 198214004032 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214004033 ABC-ATPase subunit interface; other site 198214004034 dimer interface [polypeptide binding]; other site 198214004035 putative PBP binding regions; other site 198214004036 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 198214004037 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198214004038 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 198214004039 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 198214004040 metal binding site [ion binding]; metal-binding site 198214004041 Similar to Escherichia coli K12 transposase gi: 1787607 (412 aa). BLAST with identity of 96% in 525 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214004042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004043 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004044 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004045 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004046 Integrase core domain; Region: rve; pfam00665 198214004047 Integrase core domain; Region: rve_3; pfam13683 198214004048 Transposase; Region: HTH_Tnp_1; cl17663 198214004049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004050 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198214004051 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 198214004052 exonuclease VIII; Reviewed; Region: PRK09709 198214004053 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 198214004054 hypothetical protein; Reviewed; Region: PRK09790 198214004055 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 198214004056 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214004057 HTH-like domain; Region: HTH_21; pfam13276 198214004058 Integrase core domain; Region: rve; pfam00665 198214004059 Integrase core domain; Region: rve_3; pfam13683 198214004060 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214004061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004062 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214004063 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214004064 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198214004065 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 198214004066 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198214004067 Substrate binding site [chemical binding]; other site 198214004068 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214004069 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004070 'Similar to Escherichia coli K12 protein phosphatase 1 modulates phosphoproteins, signals protein misfolding gi: 1788143 (220 aa). BLAST with identity of 99% in 642 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct.' 198214004071 putative transposase OrfB; Reviewed; Region: PHA02517 198214004072 HTH-like domain; Region: HTH_21; pfam13276 198214004073 Integrase core domain; Region: rve; pfam00665 198214004074 Integrase core domain; Region: rve_3; pfam13683 198214004075 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 198214004076 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 198214004077 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 198214004078 Methyltransferase domain; Region: Methyltransf_26; pfam13659 198214004079 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl19835 198214004080 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788138 (880 aa). BLAST with identity of 97% in 875 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004081 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 198214004082 Paraquat-inducible protein A; Region: PqiA; pfam04403 198214004083 Paraquat-inducible protein A; Region: PqiA; pfam04403 198214004084 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 198214004085 ProP expression regulator; Provisional; Region: PRK04950 198214004086 putative RNA binding sites [nucleotide binding]; other site 198214004087 carboxy-terminal protease; Provisional; Region: PRK11186 198214004088 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 198214004089 protein binding site [polypeptide binding]; other site 198214004090 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 198214004091 Catalytic dyad [active] 198214004092 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 198214004093 heat shock protein HtpX; Provisional; Region: PRK05457 198214004094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198214004096 putative substrate translocation pore; other site 198214004097 Predicted integral membrane protein [Function unknown]; Region: COG5521 198214004098 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 198214004099 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198214004100 Bacterial transcriptional regulator; Region: IclR; pfam01614 198214004101 YobH-like protein; Region: YobH; pfam13996 198214004102 PhoPQ regulatory protein; Provisional; Region: PRK10299 198214004103 YebO-like protein; Region: YebO; pfam13974 198214004104 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 198214004105 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198214004106 DNA-binding site [nucleotide binding]; DNA binding site 198214004107 RNA-binding motif; other site 198214004108 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198214004109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214004110 S-adenosylmethionine binding site [chemical binding]; other site 198214004111 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004113 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004114 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004115 hypothetical protein; Provisional; Region: PRK02913 198214004116 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 198214004117 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 198214004118 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 198214004119 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198214004120 active pocket/dimerization site; other site 198214004121 active site 198214004122 phosphorylation site [posttranslational modification] 198214004123 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 198214004124 active site 198214004125 phosphorylation site [posttranslational modification] 198214004126 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198214004127 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198214004128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198214004129 Transporter associated domain; Region: CorC_HlyC; smart01091 198214004130 phage resistance protein; Provisional; Region: PRK10551 198214004131 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198214004132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198214004133 L-serine deaminase; Provisional; Region: PRK15023 198214004134 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198214004135 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198214004136 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 198214004137 putative active site [active] 198214004138 putative CoA binding site [chemical binding]; other site 198214004139 nudix motif; other site 198214004140 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 198214004141 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198214004142 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 198214004143 hypothetical protein; Provisional; Region: PRK05114 198214004144 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 198214004145 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 198214004146 homotrimer interaction site [polypeptide binding]; other site 198214004147 putative active site [active] 198214004148 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 198214004149 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 198214004150 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198214004151 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 198214004152 Glycoprotease family; Region: Peptidase_M22; pfam00814 198214004153 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 198214004154 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 198214004155 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 198214004156 acyl-activating enzyme (AAE) consensus motif; other site 198214004157 putative AMP binding site [chemical binding]; other site 198214004158 putative active site [active] 198214004159 putative CoA binding site [chemical binding]; other site 198214004160 ribonuclease D; Provisional; Region: PRK10829 198214004161 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 198214004162 catalytic site [active] 198214004163 putative active site [active] 198214004164 putative substrate binding site [chemical binding]; other site 198214004165 Helicase and RNase D C-terminal; Region: HRDC; smart00341 198214004166 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 198214004167 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 198214004168 FMN-binding pocket [chemical binding]; other site 198214004169 flavin binding motif; other site 198214004170 phosphate binding motif [ion binding]; other site 198214004171 beta-alpha-beta structure motif; other site 198214004172 NAD binding pocket [chemical binding]; other site 198214004173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198214004174 catalytic loop [active] 198214004175 iron binding site [ion binding]; other site 198214004176 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788103 (375 aa). BLAST with identity of 99% in 206 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004178 Transposase; Region: HTH_Tnp_1; pfam01527 198214004179 putative transposase OrfB; Reviewed; Region: PHA02517 198214004180 HTH-like domain; Region: HTH_21; pfam13276 198214004181 Integrase core domain; Region: rve; pfam00665 198214004182 Integrase core domain; Region: rve_3; pfam13683 198214004183 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198214004184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198214004185 metal binding site [ion binding]; metal-binding site 198214004186 active site 198214004187 I-site; other site 198214004188 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 198214004189 Uncharacterized conserved protein [Function unknown]; Region: COG3189 198214004190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198214004192 putative substrate translocation pore; other site 198214004193 Similar to Escherichia coli K12 ARAC-type regulatory protein gi: 1788091 (274 aa). BLAST with identity of 98% in 273 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214004194 Predicted membrane protein [Function unknown]; Region: COG2707 198214004195 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 198214004196 putative deacylase active site [active] 198214004197 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788086 (557 aa). BLAST with identity of 99% in 359 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004199 Transposase; Region: HTH_Tnp_1; pfam01527 198214004200 putative transposase OrfB; Reviewed; Region: PHA02517 198214004201 HTH-like domain; Region: HTH_21; pfam13276 198214004202 Integrase core domain; Region: rve; pfam00665 198214004203 Integrase core domain; Region: rve_3; pfam13683 198214004204 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 198214004205 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214004206 active site 198214004207 catalytic tetrad [active] 198214004208 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 198214004209 active site 198214004210 phosphate binding residues; other site 198214004211 catalytic residues [active] 198214004212 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 198214004213 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198214004214 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198214004215 methionine sulfoxide reductase B; Provisional; Region: PRK00222 198214004216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 198214004217 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198214004218 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 198214004219 putative NAD(P) binding site [chemical binding]; other site 198214004220 catalytic Zn binding site [ion binding]; other site 198214004221 structural Zn binding site [ion binding]; other site 198214004222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004223 putative substrate translocation pore; other site 198214004224 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 198214004225 Similar to Escherichia coli K12 oxidoreductase gi: 1788073 (348 aa). BLAST with identity of 99% in 349 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004226 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 198214004227 intersubunit interface [polypeptide binding]; other site 198214004228 active site 198214004229 zinc binding site [ion binding]; other site 198214004230 Na+ binding site [ion binding]; other site 198214004231 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198214004232 substrate binding site [chemical binding]; other site 198214004233 ATP binding site [chemical binding]; other site 198214004234 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214004235 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 198214004236 active site 198214004237 catalytic tetrad [active] 198214004238 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198214004239 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198214004240 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214004241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004242 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 198214004243 putative substrate translocation pore; other site 198214004244 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 198214004245 catalytic triad [active] 198214004246 metal binding site [ion binding]; metal-binding site 198214004247 conserved cis-peptide bond; other site 198214004248 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 198214004249 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 198214004250 active site 198214004251 homodimer interface [polypeptide binding]; other site 198214004252 protease 4; Provisional; Region: PRK10949 198214004253 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 198214004254 tandem repeat interface [polypeptide binding]; other site 198214004255 oligomer interface [polypeptide binding]; other site 198214004256 active site residues [active] 198214004257 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 198214004258 tandem repeat interface [polypeptide binding]; other site 198214004259 oligomer interface [polypeptide binding]; other site 198214004260 active site residues [active] 198214004261 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 198214004262 putative FMN binding site [chemical binding]; other site 198214004263 selenophosphate synthetase; Provisional; Region: PRK00943 198214004264 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 198214004265 dimerization interface [polypeptide binding]; other site 198214004266 putative ATP binding site [chemical binding]; other site 198214004267 DNA topoisomerase III; Provisional; Region: PRK07726 198214004268 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 198214004269 active site 198214004270 putative interdomain interaction site [polypeptide binding]; other site 198214004271 putative metal-binding site [ion binding]; other site 198214004272 putative nucleotide binding site [chemical binding]; other site 198214004273 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198214004274 domain I; other site 198214004275 DNA binding groove [nucleotide binding] 198214004276 phosphate binding site [ion binding]; other site 198214004277 domain II; other site 198214004278 domain III; other site 198214004279 nucleotide binding site [chemical binding]; other site 198214004280 catalytic site [active] 198214004281 domain IV; other site 198214004282 hypothetical protein; Provisional; Region: PRK11380 198214004283 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 198214004284 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 198214004285 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 198214004286 NAD(P) binding site [chemical binding]; other site 198214004287 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214004288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004289 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214004290 HTH-like domain; Region: HTH_21; pfam13276 198214004291 Integrase core domain; Region: rve; pfam00665 198214004292 Integrase core domain; Region: rve_3; pfam13683 198214004293 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 198214004294 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 198214004295 active site 198214004296 8-oxo-dGMP binding site [chemical binding]; other site 198214004297 nudix motif; other site 198214004298 metal binding site [ion binding]; metal-binding site 198214004299 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 198214004300 Similar to Escherichia coli K12 thiosulfate sulfur transferase gi: 1788054 (441 aa). BLAST with identity of 97% in 440 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004301 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 198214004302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214004303 Walker A/P-loop; other site 198214004304 ATP binding site [chemical binding]; other site 198214004305 Q-loop/lid; other site 198214004306 ABC transporter signature motif; other site 198214004307 Walker B; other site 198214004308 D-loop; other site 198214004309 H-loop/switch region; other site 198214004310 Similar to Escherichia coli K12 transport system permease gi: 1788052 (497 aa). BLAST with identity of 96% in 476 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004311 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788051 (390 aa). BLAST with identity of 97% in 868 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214004312 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214004313 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214004314 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214004315 Uncharacterized conserved protein [Function unknown]; Region: COG0398 198214004316 Uncharacterized conserved protein [Function unknown]; Region: COG0398 198214004317 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 198214004318 putative catalytic site [active] 198214004319 putative phosphate binding site [ion binding]; other site 198214004320 active site 198214004321 metal binding site A [ion binding]; metal-binding site 198214004322 DNA binding site [nucleotide binding] 198214004323 putative AP binding site [nucleotide binding]; other site 198214004324 putative metal binding site B [ion binding]; other site 198214004325 Similar to Escherichia coli N-(alpha)-acetylornithine-(delta)-aminotransferase gb: AAB51148.1 (406 aa). BLAST with identity of 99% in 407 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004326 arginine succinyltransferase; Provisional; Region: PRK10456 198214004327 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 198214004328 NAD(P) binding site [chemical binding]; other site 198214004329 catalytic residues [active] 198214004330 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788041 (448 aa). BLAST with identity of 97% in 445 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004331 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 198214004332 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 198214004333 putative active site [active] 198214004334 Zn binding site [ion binding]; other site 198214004335 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 198214004336 dimer interface [polypeptide binding]; other site 198214004337 hypothetical protein; Provisional; Region: PRK11396 198214004338 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 198214004339 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198214004340 GIY-YIG motif/motif A; other site 198214004341 active site 198214004342 catalytic site [active] 198214004343 putative DNA binding site [nucleotide binding]; other site 198214004344 metal binding site [ion binding]; metal-binding site 198214004345 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 198214004346 homodimer interface [polypeptide binding]; other site 198214004347 NAD binding pocket [chemical binding]; other site 198214004348 ATP binding pocket [chemical binding]; other site 198214004349 Mg binding site [ion binding]; other site 198214004350 active-site loop [active] 198214004351 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 198214004352 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 198214004353 active site 198214004354 P-loop; other site 198214004355 phosphorylation site [posttranslational modification] 198214004356 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 198214004357 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 198214004358 methionine cluster; other site 198214004359 active site 198214004360 phosphorylation site [posttranslational modification] 198214004361 metal binding site [ion binding]; metal-binding site 198214004362 Similar to Escherichia coli K12 negative transcriptional regulator of cel operon gi: 1788030 (281 aa). BLAST with identity of 98% in 540 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214004363 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004365 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004366 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004367 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 198214004368 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 198214004369 NAD binding site [chemical binding]; other site 198214004370 sugar binding site [chemical binding]; other site 198214004371 divalent metal binding site [ion binding]; other site 198214004372 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198214004373 dimer interface [polypeptide binding]; other site 198214004374 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 198214004375 putative active site [active] 198214004376 YdjC motif; other site 198214004377 Mg binding site [ion binding]; other site 198214004378 putative homodimer interface [polypeptide binding]; other site 198214004379 hydroperoxidase II; Provisional; Region: katE; PRK11249 198214004380 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 198214004381 tetramer interface [polypeptide binding]; other site 198214004382 heme binding pocket [chemical binding]; other site 198214004383 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 198214004384 domain interactions; other site 198214004385 Cell division activator CedA; Region: CedA; pfam10729 198214004386 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004388 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004389 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004390 inner membrane protein; Provisional; Region: PRK11648 198214004391 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 198214004392 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 198214004393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214004394 motif II; other site 198214004395 YniB-like protein; Region: YniB; pfam14002 198214004396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 198214004397 Phosphotransferase enzyme family; Region: APH; pfam01636 198214004398 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 198214004399 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 198214004400 putative substrate binding site [chemical binding]; other site 198214004401 putative ATP binding site [chemical binding]; other site 198214004402 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 198214004403 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788015 (472 aa). BLAST with identity of 99% in 320 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004404 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004406 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004407 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004408 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 198214004409 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 198214004410 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 198214004411 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 198214004412 active site 198214004413 dimer interface [polypeptide binding]; other site 198214004414 motif 1; other site 198214004415 motif 2; other site 198214004416 motif 3; other site 198214004417 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 198214004418 anticodon binding site; other site 198214004419 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 198214004420 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 198214004421 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 198214004422 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 198214004423 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 198214004424 23S rRNA binding site [nucleotide binding]; other site 198214004425 L21 binding site [polypeptide binding]; other site 198214004426 L13 binding site [polypeptide binding]; other site 198214004427 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 198214004428 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 198214004429 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 198214004430 dimer interface [polypeptide binding]; other site 198214004431 motif 1; other site 198214004432 active site 198214004433 motif 2; other site 198214004434 motif 3; other site 198214004435 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 198214004436 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 198214004437 putative tRNA-binding site [nucleotide binding]; other site 198214004438 B3/4 domain; Region: B3_4; pfam03483 198214004439 tRNA synthetase B5 domain; Region: B5; smart00874 198214004440 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 198214004441 dimer interface [polypeptide binding]; other site 198214004442 motif 1; other site 198214004443 motif 3; other site 198214004444 motif 2; other site 198214004445 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 198214004446 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 198214004447 DNA binding site [nucleotide binding] 198214004448 dimer interface [polypeptide binding]; other site 198214004449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198214004450 ABC-ATPase subunit interface; other site 198214004451 dimer interface [polypeptide binding]; other site 198214004452 putative PBP binding regions; other site 198214004453 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 198214004454 catalytic residues [active] 198214004455 dimer interface [polypeptide binding]; other site 198214004456 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 198214004457 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198214004458 Walker A/P-loop; other site 198214004459 ATP binding site [chemical binding]; other site 198214004460 Q-loop/lid; other site 198214004461 ABC transporter signature motif; other site 198214004462 Walker B; other site 198214004463 D-loop; other site 198214004464 H-loop/switch region; other site 198214004465 NlpC/P60 family; Region: NLPC_P60; pfam00877 198214004466 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 198214004467 hypothetical protein; Validated; Region: PRK00029 198214004468 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 198214004469 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 198214004470 PEP synthetase regulatory protein; Provisional; Region: PRK05339 198214004471 phosphoenolpyruvate synthase; Validated; Region: PRK06464 198214004472 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 198214004473 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198214004474 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198214004475 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 198214004476 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 198214004477 acyl-activating enzyme (AAE) consensus motif; other site 198214004478 putative AMP binding site [chemical binding]; other site 198214004479 putative active site [active] 198214004480 putative CoA binding site [chemical binding]; other site 198214004481 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 198214004482 oxidoreductase; Provisional; Region: PRK10015 198214004483 putative oxidoreductase FixC; Provisional; Region: PRK10157 198214004484 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 198214004485 Electron transfer flavoprotein domain; Region: ETF; pfam01012 198214004486 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 198214004487 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 198214004488 Ligand binding site [chemical binding]; other site 198214004489 Similar to Escherichia coli K12 ARAC-type regulatory protein gi: 1787987 (304 aa). BLAST with identity of 98% in 160 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004491 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004492 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004493 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004494 transcriptional regulator YdeO; Provisional; Region: PRK09940 198214004495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214004496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214004497 putative oxidoreductase; Provisional; Region: PRK09939 198214004498 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 198214004499 putative molybdopterin cofactor binding site [chemical binding]; other site 198214004500 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 198214004501 putative molybdopterin cofactor binding site; other site 198214004502 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 198214004503 mannosyl binding site [chemical binding]; other site 198214004504 Fimbrial protein; Region: Fimbrial; pfam00419 198214004505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004506 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004507 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004508 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004509 putative transposase OrfB; Reviewed; Region: PHA02517 198214004510 HTH-like domain; Region: HTH_21; pfam13276 198214004511 Integrase core domain; Region: rve; pfam00665 198214004512 Integrase core domain; Region: rve_3; pfam13683 198214004513 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 198214004514 anti-adapter protein IraM; Provisional; Region: PRK09919 198214004515 Antitermination protein; Region: Antiterm; pfam03589 198214004516 Antitermination protein; Region: Antiterm; pfam03589 198214004517 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 198214004518 Protein of unknown function (DUF968); Region: DUF968; pfam06147 198214004519 Hok/gef family; Region: HOK_GEF; pfam01848 198214004520 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 198214004521 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 198214004522 HTH-like domain; Region: HTH_21; pfam13276 198214004523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198214004524 Integrase core domain; Region: rve; pfam00665 198214004525 Integrase core domain; Region: rve_3; pfam13683 198214004526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004527 Transposase; Region: HTH_Tnp_1; pfam01527 198214004528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004529 putative substrate translocation pore; other site 198214004530 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 198214004531 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198214004532 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198214004533 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 198214004534 malonic semialdehyde reductase; Provisional; Region: PRK10538 198214004535 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 198214004536 putative NAD(P) binding site [chemical binding]; other site 198214004537 homodimer interface [polypeptide binding]; other site 198214004538 homotetramer interface [polypeptide binding]; other site 198214004539 active site 198214004540 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 198214004541 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 198214004542 active site 198214004543 Zn binding site [ion binding]; other site 198214004544 hypothetical protein; Validated; Region: PRK03657 198214004545 putative transposase OrfB; Reviewed; Region: PHA02517 198214004546 HTH-like domain; Region: HTH_21; pfam13276 198214004547 Integrase core domain; Region: rve; pfam00665 198214004548 Integrase core domain; Region: rve_3; pfam13683 198214004549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004550 putative substrate translocation pore; other site 198214004551 putative transporter; Provisional; Region: PRK10054 198214004552 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198214004553 EamA-like transporter family; Region: EamA; pfam00892 198214004554 MarB protein; Region: MarB; pfam13999 198214004555 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 198214004556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214004557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214004558 MarR family; Region: MarR_2; cl17246 198214004559 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198214004560 inner membrane protein; Provisional; Region: PRK10995 198214004561 Similar to Escherichia coli K12 aldehyde dehydrogenase gi: 1787805 (471 aa). BLAST with identity of 98% in 240 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004562 glutaminase; Provisional; Region: PRK00971 198214004563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198214004564 metal binding site [ion binding]; metal-binding site 198214004565 active site 198214004566 I-site; other site 198214004567 altronate oxidoreductase; Provisional; Region: PRK03643 198214004568 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198214004569 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198214004570 Predicted membrane protein [Function unknown]; Region: COG3781 198214004571 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 198214004572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214004573 S-adenosylmethionine binding site [chemical binding]; other site 198214004574 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 198214004575 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 198214004576 putative active site; other site 198214004577 catalytic residue [active] 198214004578 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214004579 HTH-like domain; Region: HTH_21; pfam13276 198214004580 Integrase core domain; Region: rve; pfam00665 198214004581 Integrase core domain; Region: rve_3; pfam13683 198214004582 Similar to Escherichia coli K12 kinase gi: 1787789 (531 aa). BLAST with identity of 98% in 274 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004583 transcriptional regulator LsrR; Provisional; Region: PRK15418 198214004584 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 198214004585 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 198214004586 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 198214004587 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198214004588 Walker A/P-loop; other site 198214004589 ATP binding site [chemical binding]; other site 198214004590 Q-loop/lid; other site 198214004591 ABC transporter signature motif; other site 198214004592 Walker B; other site 198214004593 D-loop; other site 198214004594 H-loop/switch region; other site 198214004595 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198214004596 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214004597 TM-ABC transporter signature motif; other site 198214004598 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214004599 TM-ABC transporter signature motif; other site 198214004600 Similar to Escherichia coli K12 LACI-type transcriptional regulator gi: 1787795 (341 aa). BLAST with identity of 99% in 341 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004601 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214004602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004603 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214004604 HTH-like domain; Region: HTH_21; pfam13276 198214004605 Integrase core domain; Region: rve; pfam00665 198214004606 Integrase core domain; Region: rve_3; pfam13683 198214004607 putative transposase OrfB; Reviewed; Region: PHA02517 198214004608 HTH-like domain; Region: HTH_21; pfam13276 198214004609 Integrase core domain; Region: rve; pfam00665 198214004610 Integrase core domain; Region: rve_2; pfam13333 198214004611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004612 Transposase; Region: HTH_Tnp_1; pfam01527 198214004613 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 198214004614 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 198214004615 putative active site pocket [active] 198214004616 putative metal binding site [ion binding]; other site 198214004617 hypothetical protein; Provisional; Region: PRK02237 198214004618 hypothetical protein; Provisional; Region: PRK13659 198214004619 Similar to Escherichia coli K12 spermidine N1-acetyltransferase gi: 1787867 (187 aa). BLAST with identity of 98% in 187 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214004620 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 198214004621 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 198214004622 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 198214004623 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 198214004624 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198214004625 active site 198214004626 DNA binding site [nucleotide binding] 198214004627 Int/Topo IB signature motif; other site 198214004628 putative transposase OrfB; Reviewed; Region: PHA02517 198214004629 HTH-like domain; Region: HTH_21; pfam13276 198214004630 Integrase core domain; Region: rve; pfam00665 198214004631 Integrase core domain; Region: rve_3; pfam13683 198214004632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004633 Transposase; Region: HTH_Tnp_1; cl17663 198214004634 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198214004635 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 198214004636 putative molybdopterin cofactor binding site; other site 198214004637 'Similar to Escherichia coli K12 oxidoreductase, major subunit gi: 1787871 (809 aa). BLAST with identity of 98% in 681 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct.' 198214004638 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 198214004639 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214004640 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 198214004641 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 198214004642 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 198214004643 Cl- selectivity filter; other site 198214004644 Cl- binding residues [ion binding]; other site 198214004645 pore gating glutamate residue; other site 198214004646 dimer interface [polypeptide binding]; other site 198214004647 putative dithiobiotin synthetase; Provisional; Region: PRK12374 198214004648 AAA domain; Region: AAA_26; pfam13500 198214004649 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 198214004650 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198214004651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214004652 nucleotide binding site [chemical binding]; other site 198214004653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198214004654 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 198214004655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214004656 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 198214004657 dimerization interface [polypeptide binding]; other site 198214004658 substrate binding pocket [chemical binding]; other site 198214004659 Similar to Escherichia coli K12 transport protein gi: 1787880 (418 aa). BLAST with identity of 98% in 418 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004660 acid shock protein precursor; Provisional; Region: PRK03577 198214004661 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 198214004662 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 198214004663 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 198214004664 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 198214004665 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 198214004666 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 198214004667 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 198214004668 ligand binding site [chemical binding]; other site 198214004669 homodimer interface [polypeptide binding]; other site 198214004670 NAD(P) binding site [chemical binding]; other site 198214004671 trimer interface B [polypeptide binding]; other site 198214004672 trimer interface A [polypeptide binding]; other site 198214004673 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 198214004674 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198214004675 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198214004676 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198214004677 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 198214004678 Spore germination protein; Region: Spore_permease; cl17796 198214004679 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 198214004680 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 198214004681 NADP binding site [chemical binding]; other site 198214004682 substrate binding pocket [chemical binding]; other site 198214004683 active site 198214004684 GlpM protein; Region: GlpM; pfam06942 198214004685 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 198214004686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214004687 active site 198214004688 phosphorylation site [posttranslational modification] 198214004689 intermolecular recognition site; other site 198214004690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214004691 DNA binding site [nucleotide binding] 198214004692 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 198214004693 sensor protein RstB; Provisional; Region: PRK10604 198214004694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214004695 dimerization interface [polypeptide binding]; other site 198214004696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214004697 dimer interface [polypeptide binding]; other site 198214004698 phosphorylation site [posttranslational modification] 198214004699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214004700 ATP binding site [chemical binding]; other site 198214004701 Mg2+ binding site [ion binding]; other site 198214004702 G-X-G motif; other site 198214004703 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 198214004704 fumarate hydratase; Reviewed; Region: fumC; PRK00485 198214004705 Class II fumarases; Region: Fumarase_classII; cd01362 198214004706 active site 198214004707 tetramer interface [polypeptide binding]; other site 198214004708 fumarate hydratase; Provisional; Region: PRK15389 198214004709 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 198214004710 Fumarase C-terminus; Region: Fumerase_C; pfam05683 198214004711 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 198214004712 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 198214004713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 198214004714 Similar to Escherichia coli K12 glucuronide permease gi: 1787902 (458 aa). BLAST with identity of 98% in 344 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004715 beta-D-glucuronidase; Provisional; Region: PRK10150 198214004716 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 198214004717 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 198214004718 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 198214004719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198214004720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214004721 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004723 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004724 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198214004726 NAD(P) binding site [chemical binding]; other site 198214004727 active site 198214004728 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 198214004729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214004730 DNA binding site [nucleotide binding] 198214004731 domain linker motif; other site 198214004732 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 198214004733 putative dimerization interface [polypeptide binding]; other site 198214004734 putative ligand binding site [chemical binding]; other site 198214004735 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 198214004736 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 198214004737 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198214004738 active site turn [active] 198214004739 phosphorylation site [posttranslational modification] 198214004740 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 198214004741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214004742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214004743 homodimer interface [polypeptide binding]; other site 198214004744 catalytic residue [active] 198214004745 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 198214004746 active site 198214004747 purine riboside binding site [chemical binding]; other site 198214004748 putative oxidoreductase; Provisional; Region: PRK11579 198214004749 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198214004750 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198214004751 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 198214004752 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 198214004753 electron transport complex protein RsxA; Provisional; Region: PRK05151 198214004754 electron transport complex protein RnfB; Provisional; Region: PRK05113 198214004755 Putative Fe-S cluster; Region: FeS; pfam04060 198214004756 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214004757 electron transport complex protein RnfC; Provisional; Region: PRK05035 198214004758 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 198214004759 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 198214004760 SLBB domain; Region: SLBB; pfam10531 198214004761 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 198214004762 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 198214004763 electron transport complex protein RnfG; Validated; Region: PRK01908 198214004764 electron transport complex RsxE subunit; Provisional; Region: PRK12405 198214004765 endonuclease III; Provisional; Region: PRK10702 198214004766 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198214004767 minor groove reading motif; other site 198214004768 helix-hairpin-helix signature motif; other site 198214004769 substrate binding pocket [chemical binding]; other site 198214004770 active site 198214004771 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 198214004772 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 198214004773 putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584 198214004774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004775 putative substrate translocation pore; other site 198214004776 glutathionine S-transferase; Provisional; Region: PRK10542 198214004777 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 198214004778 C-terminal domain interface [polypeptide binding]; other site 198214004779 GSH binding site (G-site) [chemical binding]; other site 198214004780 dimer interface [polypeptide binding]; other site 198214004781 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 198214004782 N-terminal domain interface [polypeptide binding]; other site 198214004783 dimer interface [polypeptide binding]; other site 198214004784 substrate binding pocket (H-site) [chemical binding]; other site 198214004785 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 198214004786 dimer interface [polypeptide binding]; other site 198214004787 pyridoxal binding site [chemical binding]; other site 198214004788 ATP binding site [chemical binding]; other site 198214004789 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 198214004790 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 198214004791 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 198214004792 active site 198214004793 HIGH motif; other site 198214004794 dimer interface [polypeptide binding]; other site 198214004795 KMSKS motif; other site 198214004796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214004797 RNA binding surface [nucleotide binding]; other site 198214004798 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 198214004799 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 198214004800 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 198214004801 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 198214004802 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214004803 HTH-like domain; Region: HTH_21; pfam13276 198214004804 Integrase core domain; Region: rve; pfam00665 198214004805 Integrase core domain; Region: rve_3; pfam13683 198214004806 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214004807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214004808 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 198214004809 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 198214004810 transcriptional regulator SlyA; Provisional; Region: PRK03573 198214004811 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198214004812 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 198214004813 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 198214004814 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214004815 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214004816 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787933 (671 aa). BLAST with identity of 98% in 670 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004817 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 198214004818 E-class dimer interface [polypeptide binding]; other site 198214004819 P-class dimer interface [polypeptide binding]; other site 198214004820 active site 198214004821 Cu2+ binding site [ion binding]; other site 198214004822 Zn2+ binding site [ion binding]; other site 198214004823 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214004824 active site 198214004825 catalytic tetrad [active] 198214004826 Predicted Fe-S protein [General function prediction only]; Region: COG3313 198214004827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198214004828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214004829 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 198214004830 FMN binding site [chemical binding]; other site 198214004831 active site 198214004832 substrate binding site [chemical binding]; other site 198214004833 catalytic residue [active] 198214004834 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 198214004835 dimer interface [polypeptide binding]; other site 198214004836 active site 198214004837 metal binding site [ion binding]; metal-binding site 198214004838 glutathione binding site [chemical binding]; other site 198214004839 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 198214004840 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 198214004841 dimer interface [polypeptide binding]; other site 198214004842 catalytic site [active] 198214004843 putative active site [active] 198214004844 putative substrate binding site [chemical binding]; other site 198214004845 Similar to Escherichia coli K12 member of ATP-dependent helicase superfamily II gi: 1787942 (1539 aa). BLAST with identity of 98% in 1486 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004846 Similar to Escherichia coli K12 virulence protein gi: 1787702 (403 aa). BLAST with identity of 98% in 401 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004847 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 198214004848 putative GSH binding site [chemical binding]; other site 198214004849 catalytic residues [active] 198214004850 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198214004851 NlpC/P60 family; Region: NLPC_P60; pfam00877 198214004852 superoxide dismutase; Provisional; Region: PRK10543 198214004853 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198214004854 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198214004855 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198214004856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004857 putative substrate translocation pore; other site 198214004858 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 198214004859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214004860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214004861 dimerization interface [polypeptide binding]; other site 198214004862 putative transporter; Provisional; Region: PRK11043 198214004863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004864 putative substrate translocation pore; other site 198214004865 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 198214004866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198214004867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214004868 S-adenosylmethionine binding site [chemical binding]; other site 198214004869 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 198214004870 Lumazine binding domain; Region: Lum_binding; pfam00677 198214004871 Lumazine binding domain; Region: Lum_binding; pfam00677 198214004872 Similar to Escherichia coli K12 transport protein gi: 1787953 (458 aa). BLAST with identity of 99% in 228 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214004873 hypothetical protein; Provisional; Region: PRK09945 198214004874 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 198214004875 putative monooxygenase; Provisional; Region: PRK11118 198214004876 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787957 (535 aa). BLAST with identity of 98% in 474 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214004877 hypothetical protein; Provisional; Region: PRK09946 198214004878 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 198214004879 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 198214004880 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 198214004881 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214004882 hypothetical protein; Provisional; Region: PRK09947 198214004883 putative oxidoreductase; Provisional; Region: PRK09849 198214004884 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 198214004885 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 198214004886 hypothetical protein; Provisional; Region: PRK09898 198214004887 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214004888 hypothetical protein; Provisional; Region: PRK10292 198214004889 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004890 pyruvate kinase; Provisional; Region: PRK09206 198214004891 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 198214004892 domain interfaces; other site 198214004893 active site 198214004894 murein lipoprotein; Provisional; Region: PRK15396 198214004895 L,D-transpeptidase; Provisional; Region: PRK10260 198214004896 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214004897 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198214004898 cysteine desufuration protein SufE; Provisional; Region: PRK09296 198214004899 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787970 (407 aa). BLAST with identity of 98% in 852 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214004900 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214004901 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 198214004902 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 198214004903 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 198214004904 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 198214004905 Walker A/P-loop; other site 198214004906 ATP binding site [chemical binding]; other site 198214004907 Q-loop/lid; other site 198214004908 ABC transporter signature motif; other site 198214004909 Walker B; other site 198214004910 D-loop; other site 198214004911 H-loop/switch region; other site 198214004912 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 198214004913 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 198214004914 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 198214004915 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198214004916 CoenzymeA binding site [chemical binding]; other site 198214004917 subunit interaction site [polypeptide binding]; other site 198214004918 PHB binding site; other site 198214004919 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 198214004920 FAD binding domain; Region: FAD_binding_4; pfam01565 198214004921 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 198214004922 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198214004923 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198214004924 putative inner membrane protein; Provisional; Region: PRK10983 198214004925 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 198214004926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004927 putative substrate translocation pore; other site 198214004928 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198214004929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214004930 putative substrate translocation pore; other site 198214004931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198214004932 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 198214004933 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 198214004934 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 198214004935 shikimate binding site; other site 198214004936 NAD(P) binding site [chemical binding]; other site 198214004937 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 198214004938 active site 198214004939 catalytic residue [active] 198214004940 dimer interface [polypeptide binding]; other site 198214004941 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004943 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004944 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004945 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 198214004946 Sulfatase; Region: Sulfatase; pfam00884 198214004947 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 198214004948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214004949 FeS/SAM binding site; other site 198214004950 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 198214004951 Similar to Escherichia coli K12 ATP-binding component of a transport system gi: 1787772 (562 aa). BLAST with identity of 98% in 562 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214004952 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 198214004953 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 198214004954 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004956 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004957 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004958 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004959 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 198214004960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214004961 catalytic residue [active] 198214004962 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 198214004963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 198214004964 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 198214004965 heme-binding site [chemical binding]; other site 198214004966 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198214004967 metal binding site [ion binding]; metal-binding site 198214004968 active site 198214004969 Similar to Escherichia coli K12 enzyme gi: 1787765 (808 aa). BLAST with identity of 98% in 206 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004970 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787763 (194 aa). BLAST with identity of 97% in 111 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214004971 Similar to Escherichia coli K12 transport protein gi: 1787760 (299 aa). BLAST with identity of 98% in 299 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214004972 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198214004973 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214004974 Walker A/P-loop; other site 198214004975 ATP binding site [chemical binding]; other site 198214004976 Q-loop/lid; other site 198214004977 ABC transporter signature motif; other site 198214004978 Walker B; other site 198214004979 D-loop; other site 198214004980 H-loop/switch region; other site 198214004981 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198214004982 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198214004983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214004984 Walker A/P-loop; other site 198214004985 ATP binding site [chemical binding]; other site 198214004986 Q-loop/lid; other site 198214004987 ABC transporter signature motif; other site 198214004988 Walker B; other site 198214004989 D-loop; other site 198214004990 H-loop/switch region; other site 198214004991 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198214004992 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 198214004993 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214004994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214004995 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214004996 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214004997 malate dehydrogenase; Provisional; Region: PRK13529 198214004998 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198214004999 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 198214005000 NAD(P) binding site [chemical binding]; other site 198214005001 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 198214005002 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 198214005003 NAD binding site [chemical binding]; other site 198214005004 substrate binding site [chemical binding]; other site 198214005005 catalytic Zn binding site [ion binding]; other site 198214005006 tetramer interface [polypeptide binding]; other site 198214005007 structural Zn binding site [ion binding]; other site 198214005008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214005009 non-specific DNA binding site [nucleotide binding]; other site 198214005010 salt bridge; other site 198214005011 sequence-specific DNA binding site [nucleotide binding]; other site 198214005012 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 198214005013 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 198214005014 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214005015 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 198214005016 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 198214005017 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198214005018 [4Fe-4S] binding site [ion binding]; other site 198214005019 molybdopterin cofactor binding site; other site 198214005020 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 198214005021 molybdopterin cofactor binding site; other site 198214005022 aromatic amino acid exporter; Provisional; Region: PRK11689 198214005023 EamA-like transporter family; Region: EamA; pfam00892 198214005024 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214005026 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214005027 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214005028 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198214005029 trimer interface [polypeptide binding]; other site 198214005030 eyelet of channel; other site 198214005031 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 198214005032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214005033 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214005034 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214005035 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005036 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 198214005037 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 198214005038 'Similar to Escherichia coli K12 cryptic nitrate reductase 2, alpha subunit ref: NP_415985.1 (1246 aa). BLAST with identity of 100% in 1266 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214005039 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214005040 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 198214005041 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214005042 Putative transposase; Region: Y2_Tnp; pfam04986 198214005043 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 198214005044 DNA-binding site [nucleotide binding]; DNA binding site 198214005045 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 198214005046 FCD domain; Region: FCD; pfam07729 198214005047 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 198214005048 Prostaglandin dehydrogenases; Region: PGDH; cd05288 198214005049 NAD(P) binding site [chemical binding]; other site 198214005050 substrate binding site [chemical binding]; other site 198214005051 dimer interface [polypeptide binding]; other site 198214005052 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214005053 HTH-like domain; Region: HTH_21; pfam13276 198214005054 Integrase core domain; Region: rve; pfam00665 198214005055 Integrase core domain; Region: rve_3; pfam13683 198214005056 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214005057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198214005059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214005060 Coenzyme A binding pocket [chemical binding]; other site 198214005061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 198214005062 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 198214005063 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 198214005064 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 198214005065 trimer interface [polypeptide binding]; other site 198214005066 active site 198214005067 substrate binding site [chemical binding]; other site 198214005068 CoA binding site [chemical binding]; other site 198214005069 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 198214005070 tetrameric interface [polypeptide binding]; other site 198214005071 NAD binding site [chemical binding]; other site 198214005072 catalytic residues [active] 198214005073 substrate binding site [chemical binding]; other site 198214005074 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198214005075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214005076 dimer interface [polypeptide binding]; other site 198214005077 conserved gate region; other site 198214005078 putative PBP binding loops; other site 198214005079 ABC-ATPase subunit interface; other site 198214005080 Similar to Escherichia coli K12 transport system permease gi: 1787713 (314 aa). BLAST with identity of 100% in 115 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005081 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214005082 Putative transposase; Region: Y2_Tnp; pfam04986 198214005083 Similar to Escherichia coli K12 virulence protein gi: 1787702 (403 aa). BLAST with identity of 98% in 297 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005084 tellurite resistance protein TehB; Provisional; Region: PRK11207 198214005085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214005086 S-adenosylmethionine binding site [chemical binding]; other site 198214005087 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 198214005088 gating phenylalanine in ion channel; other site 198214005089 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 198214005090 putative trimer interface [polypeptide binding]; other site 198214005091 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 198214005092 putative CoA binding site [chemical binding]; other site 198214005093 putative trimer interface [polypeptide binding]; other site 198214005094 putative CoA binding site [chemical binding]; other site 198214005095 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198214005096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214005097 Coenzyme A binding pocket [chemical binding]; other site 198214005098 hypothetical protein; Provisional; Region: PRK11415 198214005099 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 198214005100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 198214005101 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 198214005102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214005103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214005104 dimerization interface [polypeptide binding]; other site 198214005105 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 198214005106 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198214005107 dimer interface [polypeptide binding]; other site 198214005108 ligand binding site [chemical binding]; other site 198214005109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214005110 dimerization interface [polypeptide binding]; other site 198214005111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198214005112 dimer interface [polypeptide binding]; other site 198214005113 putative CheW interface [polypeptide binding]; other site 198214005114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005115 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214005116 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214005117 putative transposase OrfB; Reviewed; Region: PHA02517 198214005118 HTH-like domain; Region: HTH_21; pfam13276 198214005119 Integrase core domain; Region: rve; pfam00665 198214005120 Integrase core domain; Region: rve_3; pfam13683 198214005121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005122 Transposase; Region: HTH_Tnp_1; pfam01527 198214005123 small toxic polypeptide; Provisional; Region: PRK09738 198214005124 hypothetical protein; Provisional; Region: PRK10040 198214005125 cytochrome b561; Provisional; Region: PRK11513 198214005126 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 198214005127 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198214005128 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198214005129 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 198214005130 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 198214005131 NAD binding site [chemical binding]; other site 198214005132 catalytic residues [active] 198214005133 substrate binding site [chemical binding]; other site 198214005134 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787683 (267 aa). BLAST with identity of 98% in 176 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005136 Transposase; Region: HTH_Tnp_1; cl17663 198214005137 putative transposase OrfB; Reviewed; Region: PHA02517 198214005138 HTH-like domain; Region: HTH_21; pfam13276 198214005139 Integrase core domain; Region: rve; pfam00665 198214005140 Integrase core domain; Region: rve_3; pfam13683 198214005141 HTH-like domain; Region: HTH_21; pfam13276 198214005142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198214005143 Integrase core domain; Region: rve; pfam00665 198214005144 Integrase core domain; Region: rve_3; pfam13683 198214005145 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 198214005146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214005147 ATP binding site [chemical binding]; other site 198214005148 putative Mg++ binding site [ion binding]; other site 198214005149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214005150 nucleotide binding region [chemical binding]; other site 198214005151 ATP-binding site [chemical binding]; other site 198214005152 Helicase associated domain (HA2); Region: HA2; pfam04408 198214005153 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 198214005154 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 198214005155 azoreductase; Reviewed; Region: PRK00170 198214005156 Similar to Escherichia coli K12 enzymes gi: 1787679 (431 aa). BLAST with identity of 98% in 850 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214005157 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 198214005158 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 198214005159 active site 198214005160 catalytic residues [active] 198214005161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005162 Transposase; Region: HTH_Tnp_1; pfam01527 198214005163 putative transposase OrfB; Reviewed; Region: PHA02517 198214005164 HTH-like domain; Region: HTH_21; pfam13276 198214005165 Integrase core domain; Region: rve; pfam00665 198214005166 Integrase core domain; Region: rve_3; pfam13683 198214005167 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 198214005168 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198214005169 active site 198214005170 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 198214005171 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198214005172 Putative methyltransferase; Region: Methyltransf_20; pfam12147 198214005173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214005174 S-adenosylmethionine binding site [chemical binding]; other site 198214005175 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 198214005176 Protein of unknown function (DUF342); Region: DUF342; cl19219 198214005177 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 198214005178 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005179 Similar to Escherichia coli K12 heat shock protein hslJ ref: NP_415897.1 (140 aa). BLAST with identity of 99% in 114 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005180 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 198214005181 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 198214005182 putative ligand binding site [chemical binding]; other site 198214005183 putative NAD binding site [chemical binding]; other site 198214005184 catalytic site [active] 198214005185 hypothetical protein; Provisional; Region: PRK10695 198214005186 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 198214005187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 198214005188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214005189 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214005190 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214005191 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005192 Similar to Escherichia coli K12 heat shock protein hslJ gi: 1787644 (141 aa). BLAST with identity of 99% in 40 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005193 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 198214005194 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 198214005195 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 198214005196 dimer interface [polypeptide binding]; other site 198214005197 PYR/PP interface [polypeptide binding]; other site 198214005198 TPP binding site [chemical binding]; other site 198214005199 substrate binding site [chemical binding]; other site 198214005200 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 198214005201 Domain of unknown function; Region: EKR; pfam10371 198214005202 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 198214005203 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 198214005204 TPP-binding site [chemical binding]; other site 198214005205 dimer interface [polypeptide binding]; other site 198214005206 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198214005207 Ligand Binding Site [chemical binding]; other site 198214005208 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 198214005209 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 198214005210 Ligand Binding Site [chemical binding]; other site 198214005211 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 198214005212 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198214005213 ATP binding site [chemical binding]; other site 198214005214 Mg++ binding site [ion binding]; other site 198214005215 motif III; other site 198214005216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214005217 nucleotide binding region [chemical binding]; other site 198214005218 ATP-binding site [chemical binding]; other site 198214005219 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 198214005220 putative RNA binding site [nucleotide binding]; other site 198214005221 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 198214005222 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 198214005223 Cl binding site [ion binding]; other site 198214005224 oligomer interface [polypeptide binding]; other site 198214005225 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787603 (431 aa). BLAST with identity of 98% in 431 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214005226 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1787602 (188 aa). BLAST with identity of 98% in 187 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214005227 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198214005228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214005229 putative substrate translocation pore; other site 198214005230 Similar to Mesorhizobium loti probable secretion protein ref: NP_103897.1 (367 aa). BLAST with identity of 46% in 906 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214005231 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214005232 Putative transposase; Region: Y2_Tnp; pfam04986 198214005233 Cupin domain; Region: Cupin_2; cl17218 198214005234 Helix-turn-helix domain; Region: HTH_18; pfam12833 198214005235 AbgT putative transporter family; Region: ABG_transport; cl17431 198214005236 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 198214005237 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 198214005238 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198214005239 DNA binding site [nucleotide binding] 198214005240 active site 198214005241 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 198214005242 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198214005243 ligand binding site [chemical binding]; other site 198214005244 flexible hinge region; other site 198214005245 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 198214005246 putative switch regulator; other site 198214005247 non-specific DNA interactions [nucleotide binding]; other site 198214005248 DNA binding site [nucleotide binding] 198214005249 sequence specific DNA binding site [nucleotide binding]; other site 198214005250 putative cAMP binding site [chemical binding]; other site 198214005251 universal stress protein UspE; Provisional; Region: PRK11175 198214005252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198214005253 Ligand Binding Site [chemical binding]; other site 198214005254 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198214005255 Ligand Binding Site [chemical binding]; other site 198214005256 putative transposase OrfB; Reviewed; Region: PHA02517 198214005257 HTH-like domain; Region: HTH_21; pfam13276 198214005258 Integrase core domain; Region: rve; pfam00665 198214005259 Integrase core domain; Region: rve_3; pfam13683 198214005260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005261 Transposase; Region: HTH_Tnp_1; cl17663 198214005262 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 198214005263 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198214005264 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198214005265 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198214005266 peptide binding site [polypeptide binding]; other site 198214005267 Similar to Escherichia coli K12 transcriptional regulator LYSR-type gi: 1787589 (300 aa). BLAST with identity of 99% in 155 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005269 Transposase; Region: HTH_Tnp_1; pfam01527 198214005270 Transposase; Region: HTH_Tnp_1; cl17663 198214005271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005272 putative transposase OrfB; Reviewed; Region: PHA02517 198214005273 HTH-like domain; Region: HTH_21; pfam13276 198214005274 Integrase core domain; Region: rve; pfam00665 198214005275 Integrase core domain; Region: rve_3; pfam13683 198214005276 Similar to Salmonella enterica subsp. enterica serovar Typhi integrase ref: NP_456439.1 (358 aa). BLAST with identity of 96% in 307 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005277 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 198214005278 Similar to Escherichia coli K12 resistance protein gi: 1788145 (291 aa). BLAST with identity of 98% in 290 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005279 hypothetical protein; Provisional; Region: PRK10301 198214005280 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 198214005281 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788148 (219 aa). BLAST with identity of 99% in 219 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214005282 exodeoxyribonuclease X; Provisional; Region: PRK07983 198214005283 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 198214005284 active site 198214005285 catalytic site [active] 198214005286 substrate binding site [chemical binding]; other site 198214005287 protease 2; Provisional; Region: PRK10115 198214005288 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198214005289 Protein of unknown function (DUF533); Region: DUF533; pfam04391 198214005290 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 198214005291 putative metal binding site [ion binding]; other site 198214005292 hypothetical protein; Provisional; Region: PRK13680 198214005293 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 198214005294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198214005295 ATP-grasp domain; Region: ATP-grasp; pfam02222 198214005296 Entner-Doudoroff aldolase; Region: eda; TIGR01182 198214005297 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 198214005298 active site 198214005299 intersubunit interface [polypeptide binding]; other site 198214005300 catalytic residue [active] 198214005301 phosphogluconate dehydratase; Validated; Region: PRK09054 198214005302 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 198214005303 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 198214005304 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 198214005305 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 198214005306 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198214005307 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198214005308 putative active site [active] 198214005309 pyruvate kinase; Provisional; Region: PRK05826 198214005310 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 198214005311 domain interfaces; other site 198214005312 active site 198214005313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198214005314 putative acyl-acceptor binding pocket; other site 198214005315 putative peptidase; Provisional; Region: PRK11649 198214005316 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 198214005317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214005318 Peptidase family M23; Region: Peptidase_M23; pfam01551 198214005319 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 198214005320 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 198214005321 metal binding site [ion binding]; metal-binding site 198214005322 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 198214005323 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198214005324 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 198214005325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214005326 Walker A motif; other site 198214005327 ATP binding site [chemical binding]; other site 198214005328 Walker B motif; other site 198214005329 arginine finger; other site 198214005330 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 198214005331 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 198214005332 RuvA N terminal domain; Region: RuvA_N; pfam01330 198214005333 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 198214005334 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 198214005335 hypothetical protein; Provisional; Region: PRK11470 198214005336 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 198214005337 active site 198214005338 putative DNA-binding cleft [nucleotide binding]; other site 198214005339 dimer interface [polypeptide binding]; other site 198214005340 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788171 (247 aa). BLAST with identity of 97% in 247 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214005341 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 198214005342 nudix motif; other site 198214005343 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 198214005344 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 198214005345 dimer interface [polypeptide binding]; other site 198214005346 anticodon binding site; other site 198214005347 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 198214005348 homodimer interface [polypeptide binding]; other site 198214005349 motif 1; other site 198214005350 active site 198214005351 motif 2; other site 198214005352 GAD domain; Region: GAD; pfam02938 198214005353 motif 3; other site 198214005354 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788174 (200 aa). BLAST with identity of 96% in 719 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214005355 ipaH island III 198214005356 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214005357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214005358 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214005359 DinI-like family; Region: DinI; pfam06183 198214005360 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214005361 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198214005362 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214005363 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214005364 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 198214005365 Phage-related protein, tail component [Function unknown]; Region: COG4733 198214005366 Putative phage tail protein; Region: Phage-tail_3; pfam13550 198214005367 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198214005368 Interdomain contacts; other site 198214005369 Cytokine receptor motif; other site 198214005370 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 198214005371 Fibronectin type III protein; Region: DUF3672; pfam12421 198214005372 Phage-related protein, tail component [Function unknown]; Region: COG4723 198214005373 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 198214005374 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198214005375 NlpC/P60 family; Region: NLPC_P60; cl17555 198214005376 Phage-related protein [Function unknown]; Region: gp18; COG4672 198214005377 Phage-related protein [Function unknown]; Region: COG4718 198214005378 Phage-related minor tail protein [Function unknown]; Region: COG5281 198214005379 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 198214005380 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 198214005381 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 198214005382 Minor tail protein T; Region: Phage_tail_T; cl05636 198214005383 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 198214005384 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 198214005385 Phage tail protein; Region: Phage_tail_3; pfam08813 198214005386 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 198214005387 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 198214005388 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 198214005389 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 198214005390 DNA packaging protein FI; Region: Packaging_FI; pfam14000 198214005391 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214005392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214005393 Y-family of DNA polymerases; Region: PolY; cl12025 198214005394 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214005395 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 198214005396 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 198214005397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005398 Transposase; Region: HTH_Tnp_1; pfam01527 198214005399 putative transposase OrfB; Reviewed; Region: PHA02517 198214005400 HTH-like domain; Region: HTH_21; pfam13276 198214005401 Integrase core domain; Region: rve; pfam00665 198214005402 Integrase core domain; Region: rve_3; pfam13683 198214005403 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 198214005404 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 198214005405 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 198214005406 ORF6N domain; Region: ORF6N; pfam10543 198214005407 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 198214005408 beta-clamp/clamp loader binding surface; other site 198214005409 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 198214005410 putative transposase OrfB; Reviewed; Region: PHA02517 198214005411 HTH-like domain; Region: HTH_21; pfam13276 198214005412 Integrase core domain; Region: rve; pfam00665 198214005413 Integrase core domain; Region: rve_3; pfam13683 198214005414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005415 Transposase; Region: HTH_Tnp_1; cl17663 198214005416 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788175 (273 aa). BLAST with identity of 99% in 114 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005417 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 198214005418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214005419 S-adenosylmethionine binding site [chemical binding]; other site 198214005420 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 198214005421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214005422 S-adenosylmethionine binding site [chemical binding]; other site 198214005423 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 198214005424 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 198214005425 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 198214005426 molybdopterin cofactor binding site [chemical binding]; other site 198214005427 substrate binding site [chemical binding]; other site 198214005428 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 198214005429 molybdopterin cofactor binding site; other site 198214005430 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 198214005431 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 198214005432 copper homeostasis protein CutC; Provisional; Region: PRK11572 198214005433 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 198214005434 putative metal binding site [ion binding]; other site 198214005435 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 198214005436 arginyl-tRNA synthetase; Region: argS; TIGR00456 198214005437 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 198214005438 active site 198214005439 HIGH motif; other site 198214005440 KMSK motif region; other site 198214005441 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 198214005442 tRNA binding surface [nucleotide binding]; other site 198214005443 anticodon binding site; other site 198214005444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 198214005445 Transposase; Region: HTH_Tnp_1; cl17663 198214005446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005447 Flagellar protein FlhE; Region: FlhE; pfam06366 198214005448 Similar to Escherichia coli K12 flagellar biosynthesis; possible export of flagellar proteins gi: 1788187 (693 aa). BLAST with identity of 99% in 691 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005449 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 198214005450 putative transposase OrfB; Reviewed; Region: PHA02517 198214005451 HTH-like domain; Region: HTH_21; pfam13276 198214005452 Integrase core domain; Region: rve; pfam00665 198214005453 Integrase core domain; Region: rve_3; pfam13683 198214005454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005455 Transposase; Region: HTH_Tnp_1; cl17663 198214005456 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 198214005457 metal binding triad [ion binding]; metal-binding site 198214005458 putative transposase OrfB; Reviewed; Region: PHA02517 198214005459 HTH-like domain; Region: HTH_21; pfam13276 198214005460 Integrase core domain; Region: rve; pfam00665 198214005461 Integrase core domain; Region: rve_3; pfam13683 198214005462 chemotaxis regulator CheZ; Provisional; Region: PRK11166 198214005463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214005464 active site 198214005465 phosphorylation site [posttranslational modification] 198214005466 intermolecular recognition site; other site 198214005467 dimerization interface [polypeptide binding]; other site 198214005468 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 198214005469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214005470 active site 198214005471 phosphorylation site [posttranslational modification] 198214005472 intermolecular recognition site; other site 198214005473 dimerization interface [polypeptide binding]; other site 198214005474 CheB methylesterase; Region: CheB_methylest; pfam01339 198214005475 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 198214005476 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 198214005477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214005478 S-adenosylmethionine binding site [chemical binding]; other site 198214005479 methyl-accepting protein IV; Provisional; Region: PRK09793 198214005480 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198214005481 dimer interface [polypeptide binding]; other site 198214005482 ligand binding site [chemical binding]; other site 198214005483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214005484 dimerization interface [polypeptide binding]; other site 198214005485 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198214005486 dimer interface [polypeptide binding]; other site 198214005487 putative CheW interface [polypeptide binding]; other site 198214005488 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 198214005489 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198214005490 dimer interface [polypeptide binding]; other site 198214005491 ligand binding site [chemical binding]; other site 198214005492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214005493 dimerization interface [polypeptide binding]; other site 198214005494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198214005495 dimer interface [polypeptide binding]; other site 198214005496 putative CheW interface [polypeptide binding]; other site 198214005497 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 198214005498 putative CheA interaction surface; other site 198214005499 chemotaxis protein CheA; Provisional; Region: PRK10547 198214005500 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198214005501 putative binding surface; other site 198214005502 active site 198214005503 CheY binding; Region: CheY-binding; pfam09078 198214005504 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 198214005505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214005506 ATP binding site [chemical binding]; other site 198214005507 Mg2+ binding site [ion binding]; other site 198214005508 G-X-G motif; other site 198214005509 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 198214005510 flagellar motor protein MotB; Validated; Region: motB; PRK09041 198214005511 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 198214005512 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198214005513 ligand binding site [chemical binding]; other site 198214005514 flagellar motor protein MotA; Validated; Region: PRK09110 198214005515 transcriptional activator FlhC; Provisional; Region: PRK12722 198214005516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214005517 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214005518 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214005519 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005520 Similar to Escherichia coli K12 trehalose-6-phosphate synthase gi: 1788206 (475 aa). BLAST with identity of 97% in 148 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005521 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 198214005522 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 198214005523 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214005524 TM-ABC transporter signature motif; other site 198214005525 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 198214005526 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198214005527 Walker A/P-loop; other site 198214005528 ATP binding site [chemical binding]; other site 198214005529 Q-loop/lid; other site 198214005530 ABC transporter signature motif; other site 198214005531 Walker B; other site 198214005532 D-loop; other site 198214005533 H-loop/switch region; other site 198214005534 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198214005535 Similar to Escherichia coli K12 L-arabinose-binding periplasmic protein gi: 1788211 (330 aa). BLAST with identity of 97% in 329 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005536 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 198214005537 Ferritin-like domain; Region: Ferritin; pfam00210 198214005538 ferroxidase diiron center [ion binding]; other site 198214005539 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 198214005540 YecR-like lipoprotein; Region: YecR; pfam13992 198214005541 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 198214005542 Ferritin-like domain; Region: Ferritin; pfam00210 198214005543 ferroxidase diiron center [ion binding]; other site 198214005544 probable metal-binding protein; Region: matur_matur; TIGR03853 198214005545 tyrosine transporter TyrP; Provisional; Region: PRK15132 198214005546 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198214005547 hypothetical protein; Provisional; Region: PRK10396 198214005548 yecA family protein; Region: ygfB_yecA; TIGR02292 198214005549 SEC-C motif; Region: SEC-C; cl19389 198214005550 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 198214005551 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 198214005552 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198214005553 active site 198214005554 catalytic site [active] 198214005555 putative DNA binding site [nucleotide binding]; other site 198214005556 GIY-YIG motif/motif A; other site 198214005557 metal binding site [ion binding]; metal-binding site 198214005558 UvrB/uvrC motif; Region: UVR; pfam02151 198214005559 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 198214005560 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 198214005561 response regulator; Provisional; Region: PRK09483 198214005562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214005563 active site 198214005564 phosphorylation site [posttranslational modification] 198214005565 intermolecular recognition site; other site 198214005566 dimerization interface [polypeptide binding]; other site 198214005567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214005568 DNA binding residues [nucleotide binding] 198214005569 dimerization interface [polypeptide binding]; other site 198214005570 hypothetical protein; Provisional; Region: PRK10613 198214005571 Autoinducer binding domain; Region: Autoind_bind; pfam03472 198214005572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 198214005573 DNA binding residues [nucleotide binding] 198214005574 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 198214005575 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198214005576 Walker A/P-loop; other site 198214005577 ATP binding site [chemical binding]; other site 198214005578 Q-loop/lid; other site 198214005579 ABC transporter signature motif; other site 198214005580 Walker B; other site 198214005581 D-loop; other site 198214005582 H-loop/switch region; other site 198214005583 amino acid ABC transporter permease; Provisional; Region: PRK15100 198214005584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214005585 dimer interface [polypeptide binding]; other site 198214005586 conserved gate region; other site 198214005587 putative PBP binding loops; other site 198214005588 ABC-ATPase subunit interface; other site 198214005589 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 198214005590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214005591 catalytic residue [active] 198214005592 cystine transporter subunit; Provisional; Region: PRK11260 198214005593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214005594 substrate binding pocket [chemical binding]; other site 198214005595 membrane-bound complex binding site; other site 198214005596 hinge residues; other site 198214005597 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 198214005598 Similar to Escherichia coli K12 flagellar biosynthesis; alternative sigma factor 28; regulation of flagellar operons gi: 1788231 (240 aa). BLAST with identity of 98% in 239 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214005599 flagellin; Validated; Region: PRK08026 198214005600 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 198214005601 Flagellin protein; Region: FliC; pfam12445 198214005602 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 198214005603 flagellar capping protein; Reviewed; Region: fliD; PRK08032 198214005604 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 198214005605 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 198214005606 Flagellar protein FliS; Region: FliS; cl00654 198214005607 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 198214005608 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 198214005609 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 198214005610 active site 198214005611 Na/Ca binding site [ion binding]; other site 198214005612 catalytic site [active] 198214005613 lipoprotein; Provisional; Region: PRK10397 198214005614 putative inner membrane protein; Provisional; Region: PRK11099 198214005615 Predicted transporter component [General function prediction only]; Region: COG2391 198214005616 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 198214005617 CPxP motif; other site 198214005618 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788240 (218 aa). BLAST with identity of 94% in 218 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005619 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198214005620 trimer interface [polypeptide binding]; other site 198214005621 eyelet of channel; other site 198214005622 transcriptional regulator HilD; Provisional; Region: PRK15185 198214005623 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 198214005624 substrate binding site [chemical binding]; other site 198214005625 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 198214005626 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788246 (93 aa). BLAST with identity of 94% in 76 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005627 flagellar hook-basal body complex protein FliE; Region: fliE; TIGR00205 198214005628 Similar to Escherichia coli K12 flagellar biosynthesis; basal-body MS(membrane and supramembrane)-ring and collar protein gi: 1788248 (553 aa). BLAST with identity of 96% in 553 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005629 flagellar motor switch protein FliG; Region: fliG; TIGR00207 198214005630 FliG N-terminal domain; Region: FliG_N; pfam14842 198214005631 FliG middle domain; Region: FliG_M; pfam14841 198214005632 FliG C-terminal domain; Region: FliG_C; pfam01706 198214005633 flagellar assembly protein H; Validated; Region: fliH; PRK05687 198214005634 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 198214005635 Flagellar assembly protein FliH; Region: FliH; pfam02108 198214005636 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 198214005637 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 198214005638 Walker A motif/ATP binding site; other site 198214005639 Walker B motif; other site 198214005640 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 198214005641 flagellar hook-length control protein; Provisional; Region: PRK10118 198214005642 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 198214005643 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 198214005644 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 198214005645 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 198214005646 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 198214005647 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 198214005648 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 198214005649 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 198214005650 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 198214005651 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 198214005652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214005653 DNA binding residues [nucleotide binding] 198214005654 dimerization interface [polypeptide binding]; other site 198214005655 hypothetical protein; Provisional; Region: PRK10708 198214005656 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 198214005657 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788265 (272 aa). BLAST with identity of 96% in 272 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005658 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 198214005659 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198214005660 metal binding site [ion binding]; metal-binding site 198214005661 active site 198214005662 I-site; other site 198214005663 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 198214005664 hypothetical protein; Provisional; Region: PRK10062 198214005665 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 198214005666 EamA-like transporter family; Region: EamA; pfam00892 198214005667 EamA-like transporter family; Region: EamA; pfam00892 198214005668 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 198214005669 additional DNA contacts [nucleotide binding]; other site 198214005670 mismatch recognition site; other site 198214005671 active site 198214005672 zinc binding site [ion binding]; other site 198214005673 DNA intercalation site [nucleotide binding]; other site 198214005674 DNA cytosine methylase; Provisional; Region: PRK10458 198214005675 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 198214005676 cofactor binding site; other site 198214005677 DNA binding site [nucleotide binding] 198214005678 substrate interaction site [chemical binding]; other site 198214005679 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788273 (232 aa). BLAST with identity of 96% in 180 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214005680 putative transposase OrfB; Reviewed; Region: PHA02517 198214005681 HTH-like domain; Region: HTH_21; pfam13276 198214005682 Integrase core domain; Region: rve; pfam00665 198214005683 Integrase core domain; Region: rve_2; pfam13333 198214005684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005685 Transposase; Region: HTH_Tnp_1; pfam01527 198214005686 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198214005687 eyelet of channel; other site 198214005688 trimer interface [polypeptide binding]; other site 198214005689 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214005690 HTH-like domain; Region: HTH_21; pfam13276 198214005691 Integrase core domain; Region: rve; pfam00665 198214005692 Integrase core domain; Region: rve_3; pfam13683 198214005693 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214005694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214005696 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214005697 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214005698 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005699 chaperone protein HchA; Provisional; Region: PRK04155 198214005700 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 198214005701 conserved cys residue [active] 198214005702 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 198214005703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214005704 dimer interface [polypeptide binding]; other site 198214005705 phosphorylation site [posttranslational modification] 198214005706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214005707 ATP binding site [chemical binding]; other site 198214005708 Mg2+ binding site [ion binding]; other site 198214005709 G-X-G motif; other site 198214005710 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 198214005711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214005712 active site 198214005713 phosphorylation site [posttranslational modification] 198214005714 intermolecular recognition site; other site 198214005715 dimerization interface [polypeptide binding]; other site 198214005716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214005717 DNA binding site [nucleotide binding] 198214005718 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 198214005719 active site 198214005720 homotetramer interface [polypeptide binding]; other site 198214005721 Similar to Escherichia coli K12 reductase gi: 1788282 (335 aa). BLAST with identity of 97% in 335 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005722 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 198214005723 zinc/cadmium-binding protein; Provisional; Region: PRK10306 198214005724 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198214005725 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198214005726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214005727 S-adenosylmethionine binding site [chemical binding]; other site 198214005728 ipaH island IV 198214005729 Similar to Shigella flexneri IpaH9.8 gb: AAC23714.1 (545 aa). BLAST with identity of 77% in 994 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214005730 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214005731 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214005732 putative transposase OrfB; Reviewed; Region: PHA02517 198214005733 HTH-like domain; Region: HTH_21; pfam13276 198214005734 Integrase core domain; Region: rve; pfam00665 198214005735 Integrase core domain; Region: rve_3; pfam13683 198214005736 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005737 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 198214005738 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 198214005739 Phage tail tube protein; Region: Tail_tube; pfam10618 198214005740 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 198214005741 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 198214005742 putative transposase OrfB; Reviewed; Region: PHA02517 198214005743 HTH-like domain; Region: HTH_21; pfam13276 198214005744 Integrase core domain; Region: rve; pfam00665 198214005745 Integrase core domain; Region: rve_3; pfam13683 198214005746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005747 Transposase; Region: HTH_Tnp_1; pfam01527 198214005748 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214005749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214005750 Homeodomain-like domain; Region: HTH_23; pfam13384 198214005751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005752 Transposase; Region: HTH_Tnp_1; pfam01527 198214005753 Lysis protein S; Region: Lysis_S; pfam04971 198214005754 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 198214005755 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 198214005756 Protein of unknown function (DUF968); Region: DUF968; pfam06147 198214005757 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198214005758 active site 198214005759 Hok/gef family; Region: HOK_GEF; pfam01848 198214005760 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 198214005761 putative transposase OrfB; Reviewed; Region: PHA02517 198214005762 HTH-like domain; Region: HTH_21; pfam13276 198214005763 Integrase core domain; Region: rve; pfam00665 198214005764 Integrase core domain; Region: rve_3; pfam13683 198214005765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005766 Transposase; Region: HTH_Tnp_1; cl17663 198214005767 'Similar to Escherichia coli K12 transport protein, shikimate gi: 1788292 (439 aa). BLAST with identity of 97% in 643 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct.' 198214005768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005769 Transposase; Region: HTH_Tnp_1; pfam01527 198214005770 putative transposase OrfB; Reviewed; Region: PHA02517 198214005771 HTH-like domain; Region: HTH_21; pfam13276 198214005772 Integrase core domain; Region: rve; pfam00665 198214005773 Integrase core domain; Region: rve_3; pfam13683 198214005774 AMP nucleosidase; Provisional; Region: PRK08292 198214005775 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 198214005776 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 198214005777 hypothetical protein; Provisional; Region: PRK12378 198214005778 Similar to Escherichia coli K12 conserved hypothetical protein gi: 2367126 (548 aa). BLAST with identity of 98% in 542 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005779 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 198214005780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214005781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214005782 dimerization interface [polypeptide binding]; other site 198214005783 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 198214005784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214005785 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 198214005786 putative dimerization interface [polypeptide binding]; other site 198214005787 L,D-transpeptidase; Provisional; Region: PRK10190 198214005788 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198214005789 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 198214005790 putative dimer interface [polypeptide binding]; other site 198214005791 active site pocket [active] 198214005792 putative cataytic base [active] 198214005793 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 198214005794 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 198214005795 GTP binding site [chemical binding]; other site 198214005796 Walker B motif; other site 198214005797 homotrimer interface [polypeptide binding]; other site 198214005798 putative transposase OrfB; Reviewed; Region: PHA02517 198214005799 HTH-like domain; Region: HTH_21; pfam13276 198214005800 Integrase core domain; Region: rve; pfam00665 198214005801 Integrase core domain; Region: rve_3; pfam13683 198214005802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005803 Transposase; Region: HTH_Tnp_1; pfam01527 198214005804 Transposase; Region: HTH_Tnp_1; cl17663 198214005805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214005806 HTH-like domain; Region: HTH_21; pfam13276 198214005807 Integrase core domain; Region: rve; pfam00665 198214005808 Integrase core domain; Region: rve_3; pfam13683 198214005809 hypothetical protein; Provisional; Region: PRK05423 198214005810 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788318 (353 aa). BLAST with identity of 97% in 40 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005811 Integrase core domain; Region: rve; pfam00665 198214005812 Integrase core domain; Region: rve_3; pfam13683 198214005813 exonuclease I; Provisional; Region: sbcB; PRK11779 198214005814 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 198214005815 active site 198214005816 catalytic site [active] 198214005817 substrate binding site [chemical binding]; other site 198214005818 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 198214005819 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 198214005820 CPxP motif; other site 198214005821 Predicted transporter component [General function prediction only]; Region: COG2391 198214005822 Sulphur transport; Region: Sulf_transp; cl19477 198214005823 Sulphur transport; Region: Sulf_transp; cl19477 198214005824 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198214005825 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214005826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214005827 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 198214005828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214005829 dimerization interface [polypeptide binding]; other site 198214005830 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198214005831 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 198214005832 putative NAD(P) binding site [chemical binding]; other site 198214005833 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 198214005834 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214005836 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214005837 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214005838 antitoxin YefM; Provisional; Region: PRK11409 198214005839 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 198214005840 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 198214005841 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 198214005842 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 198214005843 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 198214005844 NAD binding site [chemical binding]; other site 198214005845 dimerization interface [polypeptide binding]; other site 198214005846 product binding site; other site 198214005847 substrate binding site [chemical binding]; other site 198214005848 zinc binding site [ion binding]; other site 198214005849 catalytic residues [active] 198214005850 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 198214005851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214005852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214005853 homodimer interface [polypeptide binding]; other site 198214005854 catalytic residue [active] 198214005855 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 198214005856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214005857 active site 198214005858 motif I; other site 198214005859 motif II; other site 198214005860 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 198214005861 putative active site pocket [active] 198214005862 4-fold oligomerization interface [polypeptide binding]; other site 198214005863 metal binding residues [ion binding]; metal-binding site 198214005864 3-fold/trimer interface [polypeptide binding]; other site 198214005865 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 198214005866 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 198214005867 putative active site [active] 198214005868 oxyanion strand; other site 198214005869 catalytic triad [active] 198214005870 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 198214005871 catalytic residues [active] 198214005872 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 198214005873 substrate binding site [chemical binding]; other site 198214005874 glutamase interaction surface [polypeptide binding]; other site 198214005875 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 198214005876 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 198214005877 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 198214005878 metal binding site [ion binding]; metal-binding site 198214005879 chain length determinant protein WzzB; Provisional; Region: PRK15471 198214005880 Chain length determinant protein; Region: Wzz; pfam02706 198214005881 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198214005882 Similar to Escherichia coli K12 UDP-glucose 6-dehydrogenase gi: 1788340 (389 aa). BLAST with identity of 96% in 373 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005883 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 198214005884 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 198214005885 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 198214005886 potential frameshift: common BLAST hit: gi|313200833|ref|YP_004039491.1| dolichyl-phosphate-mannose-protein mannosyltransferase 198214005887 GtrA-like protein; Region: GtrA; pfam04138 198214005888 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198214005889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198214005890 active site 198214005891 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 198214005892 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 198214005893 Ligand binding site; other site 198214005894 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198214005895 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 198214005896 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 198214005897 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 198214005898 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 198214005899 substrate binding site; other site 198214005900 tetramer interface; other site 198214005901 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 198214005902 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 198214005903 NADP binding site [chemical binding]; other site 198214005904 active site 198214005905 putative substrate binding site [chemical binding]; other site 198214005906 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 198214005907 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 198214005908 NAD binding site [chemical binding]; other site 198214005909 substrate binding site [chemical binding]; other site 198214005910 homodimer interface [polypeptide binding]; other site 198214005911 active site 198214005912 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 198214005913 active site 198214005914 tetramer interface; other site 198214005915 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 198214005916 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 198214005917 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 198214005918 putative ADP-binding pocket [chemical binding]; other site 198214005919 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 198214005920 colanic acid exporter; Provisional; Region: PRK10459 198214005921 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 198214005922 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 198214005923 CoA-binding domain; Region: CoA_binding_3; pfam13727 198214005924 Bacterial sugar transferase; Region: Bac_transf; pfam02397 198214005925 phosphomannomutase CpsG; Provisional; Region: PRK15414 198214005926 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 198214005927 active site 198214005928 substrate binding site [chemical binding]; other site 198214005929 metal binding site [ion binding]; metal-binding site 198214005930 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 198214005931 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 198214005932 Substrate binding site; other site 198214005933 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 198214005934 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 198214005935 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 198214005936 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 198214005937 active site 198214005938 GDP-Mannose binding site [chemical binding]; other site 198214005939 dimer interface [polypeptide binding]; other site 198214005940 modified nudix motif 198214005941 metal binding site [ion binding]; metal-binding site 198214005942 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 198214005943 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 198214005944 NADP binding site [chemical binding]; other site 198214005945 active site 198214005946 putative substrate binding site [chemical binding]; other site 198214005947 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 198214005948 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 198214005949 NADP-binding site; other site 198214005950 homotetramer interface [polypeptide binding]; other site 198214005951 substrate binding site [chemical binding]; other site 198214005952 homodimer interface [polypeptide binding]; other site 198214005953 active site 198214005954 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 198214005955 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 198214005956 putative trimer interface [polypeptide binding]; other site 198214005957 putative active site [active] 198214005958 putative substrate binding site [chemical binding]; other site 198214005959 putative CoA binding site [chemical binding]; other site 198214005960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214005961 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214005962 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214005963 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214005964 Similar to Escherichia coli K12 colanic acid polymerase ref: NP_416560.1 (405 aa). BLAST with identity of 96% in 324 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214005965 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198214005966 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 198214005967 putative acyl transferase; Provisional; Region: PRK10191 198214005968 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 198214005969 trimer interface [polypeptide binding]; other site 198214005970 active site 198214005971 substrate binding site [chemical binding]; other site 198214005972 CoA binding site [chemical binding]; other site 198214005973 Similar to Escherichia coli K12 regulator gi: 1788372 (280 aa). BLAST with identity of 96% in 279 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214005974 tyrosine kinase; Provisional; Region: PRK11519 198214005975 Chain length determinant protein; Region: Wzz; pfam02706 198214005976 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198214005977 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198214005978 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198214005979 active site 198214005980 polysaccharide export protein Wza; Provisional; Region: PRK15078 198214005981 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 198214005982 SLBB domain; Region: SLBB; pfam10531 198214005983 SLBB domain; Region: SLBB; pfam10531 198214005984 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198214005985 FOG: CBS domain [General function prediction only]; Region: COG0517 198214005986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198214005987 Transporter associated domain; Region: CorC_HlyC; smart01091 198214005988 putative assembly protein; Provisional; Region: PRK10833 198214005989 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198214005990 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 198214005991 trimer interface [polypeptide binding]; other site 198214005992 active site 198214005993 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 198214005994 ATP-binding site [chemical binding]; other site 198214005995 Sugar specificity; other site 198214005996 Pyrimidine base specificity; other site 198214005997 Similar to Escherichia coli K12 sensor-type protein gi: 1788381 (1106 aa). BLAST with identity of 97% in 1586 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214005998 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214005999 Y-family of DNA polymerases; Region: PolY; cl12025 198214006000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214006001 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214006002 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 198214006003 AlkA N-terminal domain; Region: AlkA_N; smart01009 198214006004 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198214006005 minor groove reading motif; other site 198214006006 helix-hairpin-helix signature motif; other site 198214006007 substrate binding pocket [chemical binding]; other site 198214006008 active site 198214006009 Similar to Escherichia coli K12 heat shock protein gi: 1788384 (472 aa). BLAST with identity of 98% in 472 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006010 Protein phosphatase 2C; Region: PP2C_2; pfam13672 198214006011 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 198214006012 metal ion-dependent adhesion site (MIDAS); other site 198214006013 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214006014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214006015 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214006016 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198214006017 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214006018 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214006019 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 198214006020 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788390 (1041 aa). BLAST with identity of 98% in 1041 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006021 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 198214006022 MMPL family; Region: MMPL; cl14618 198214006023 putative transporter; Provisional; Region: PRK10504 198214006024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214006025 putative substrate translocation pore; other site 198214006026 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 198214006027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214006028 dimerization interface [polypeptide binding]; other site 198214006029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214006030 dimer interface [polypeptide binding]; other site 198214006031 phosphorylation site [posttranslational modification] 198214006032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214006033 ATP binding site [chemical binding]; other site 198214006034 Mg2+ binding site [ion binding]; other site 198214006035 G-X-G motif; other site 198214006036 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 198214006037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006038 active site 198214006039 phosphorylation site [posttranslational modification] 198214006040 intermolecular recognition site; other site 198214006041 dimerization interface [polypeptide binding]; other site 198214006042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214006043 DNA binding site [nucleotide binding] 198214006044 Uncharacterized conserved protein [Function unknown]; Region: COG3422 198214006045 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 198214006046 putative protease; Provisional; Region: PRK15452 198214006047 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198214006048 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788400 (89 aa). BLAST with identity of 94% in 49 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214006049 lipid kinase; Reviewed; Region: PRK13054 198214006050 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 198214006051 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198214006052 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198214006053 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214006054 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 198214006055 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 198214006056 putative NAD(P) binding site [chemical binding]; other site 198214006057 catalytic Zn binding site [ion binding]; other site 198214006058 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006060 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006061 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006062 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 198214006063 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 198214006064 active site 198214006065 P-loop; other site 198214006066 phosphorylation site [posttranslational modification] 198214006067 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214006068 active site 198214006069 phosphorylation site [posttranslational modification] 198214006070 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 198214006071 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 198214006072 intersubunit interface [polypeptide binding]; other site 198214006073 active site 198214006074 zinc binding site [ion binding]; other site 198214006075 Na+ binding site [ion binding]; other site 198214006076 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 198214006077 putative active site; other site 198214006078 catalytic residue [active] 198214006079 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788416 (335 aa). BLAST with identity of 97% in 335 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006080 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 198214006081 substrate binding site [chemical binding]; other site 198214006082 ATP binding site [chemical binding]; other site 198214006083 Similar to Escherichia coli K12 transcriptional regulator gi: 1788418 (249 aa). BLAST with identity of 98% in 694 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214006084 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214006085 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 198214006086 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 198214006087 active site 198214006088 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 198214006089 dimer interface [polypeptide binding]; other site 198214006090 substrate binding site [chemical binding]; other site 198214006091 ATP binding site [chemical binding]; other site 198214006092 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 198214006093 substrate binding site [chemical binding]; other site 198214006094 multimerization interface [polypeptide binding]; other site 198214006095 ATP binding site [chemical binding]; other site 198214006096 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 198214006097 putative metal binding site [ion binding]; other site 198214006098 putative homodimer interface [polypeptide binding]; other site 198214006099 putative homotetramer interface [polypeptide binding]; other site 198214006100 putative homodimer-homodimer interface [polypeptide binding]; other site 198214006101 putative allosteric switch controlling residues; other site 198214006102 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788423 (275 aa). BLAST with identity of 98% in 277 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006103 Predicted integral membrane protein [Function unknown]; Region: COG5455 198214006104 Fimbrial protein; Region: Fimbrial; cl01416 198214006105 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 198214006106 PapC N-terminal domain; Region: PapC_N; pfam13954 198214006107 Outer membrane usher protein; Region: Usher; pfam00577 198214006108 PapC C-terminal domain; Region: PapC_C; pfam13953 198214006109 Similar to Escherichia coli K12 chaperone gi: 1788428 (240 aa). BLAST with identity of 97% in 498 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214006110 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 198214006111 Fimbrial protein; Region: Fimbrial; cl01416 198214006112 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006114 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006115 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006116 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 198214006117 antiporter inner membrane protein; Provisional; Region: PRK11670 198214006118 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 198214006119 Walker A motif; other site 198214006120 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 198214006121 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 198214006122 active site 198214006123 HIGH motif; other site 198214006124 KMSKS motif; other site 198214006125 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 198214006126 tRNA binding surface [nucleotide binding]; other site 198214006127 anticodon binding site; other site 198214006128 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 198214006129 dimer interface [polypeptide binding]; other site 198214006130 putative tRNA-binding site [nucleotide binding]; other site 198214006131 'Similar to Escherichia coli K12 molybdate metabolism regulator, first fragment gi: 1788433 (275 aa). BLAST with identity of 98% in 956 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct.' 198214006132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214006133 Transposase; Region: HTH_Tnp_1; pfam01527 198214006134 putative transposase OrfB; Reviewed; Region: PHA02517 198214006135 HTH-like domain; Region: HTH_21; pfam13276 198214006136 Integrase core domain; Region: rve; pfam00665 198214006137 Integrase core domain; Region: rve_3; pfam13683 198214006138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006139 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006140 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006141 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006142 'Similar to Escherichia coli K12 molybdate metabolism regulator, second fragment 2 gi: 1788434 (646 aa). BLAST with identity of 96% in 648 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214006143 Similar to Escherichia coli K12 regulator ref: NP_416621.1 (1210 aa). BLAST with identity of 81% in 1215 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006144 MoxR-like ATPases [General function prediction only]; Region: COG0714 198214006145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214006146 Walker A motif; other site 198214006147 ATP binding site [chemical binding]; other site 198214006148 Walker B motif; other site 198214006149 arginine finger; other site 198214006150 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 198214006151 metal ion-dependent adhesion site (MIDAS); other site 198214006152 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 198214006154 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006156 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006157 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006158 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 198214006159 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 198214006160 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 198214006161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006162 active site 198214006163 phosphorylation site [posttranslational modification] 198214006164 intermolecular recognition site; other site 198214006165 dimerization interface [polypeptide binding]; other site 198214006166 LytTr DNA-binding domain; Region: LytTR; pfam04397 198214006167 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 198214006168 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198214006169 GAF domain; Region: GAF; pfam01590 198214006170 Histidine kinase; Region: His_kinase; pfam06580 198214006171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214006172 ATP binding site [chemical binding]; other site 198214006173 Mg2+ binding site [ion binding]; other site 198214006174 G-X-G motif; other site 198214006175 Similar to Shigella flexneri conserved hypothetical protein ref: NP_085397.1 (448 aa). BLAST with identity of 77% in 448 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006176 DinI-like family; Region: DinI; pfam06183 198214006177 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198214006178 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198214006179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214006180 S-adenosylmethionine binding site [chemical binding]; other site 198214006181 Similar to Shigella flexneri IpaH9.8 gb: AAC23714.1 (545 aa). BLAST with identity of 77% in 994 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214006182 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214006183 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214006184 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 198214006185 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198214006186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006187 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006188 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006189 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006190 Similar to Escherichia coli K12 transcriptional regulator gi: 1788448 (244 aa). BLAST with identity of 98% in 666 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214006191 Transposase; Region: HTH_Tnp_1; cl17663 198214006192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214006193 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198214006194 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 198214006195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214006196 dimer interface [polypeptide binding]; other site 198214006197 conserved gate region; other site 198214006198 putative PBP binding loops; other site 198214006199 ABC-ATPase subunit interface; other site 198214006200 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 198214006201 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 198214006202 Walker A/P-loop; other site 198214006203 ATP binding site [chemical binding]; other site 198214006204 Q-loop/lid; other site 198214006205 ABC transporter signature motif; other site 198214006206 Walker B; other site 198214006207 D-loop; other site 198214006208 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 198214006209 H-loop/switch region; other site 198214006210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214006211 dimer interface [polypeptide binding]; other site 198214006212 conserved gate region; other site 198214006213 putative PBP binding loops; other site 198214006214 ABC-ATPase subunit interface; other site 198214006215 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 198214006216 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 198214006217 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 198214006218 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 198214006219 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 198214006220 D-lactate dehydrogenase; Provisional; Region: PRK11183 198214006221 FAD binding domain; Region: FAD_binding_4; cl19922 198214006222 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 198214006223 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 198214006224 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 198214006225 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 198214006226 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198214006227 Similar to Escherichia coli K12 oxidoreductase gi: 1788459 (254 aa). BLAST with identity of 95% in 253 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006228 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198214006229 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 198214006230 FMN binding site [chemical binding]; other site 198214006231 active site 198214006232 catalytic residues [active] 198214006233 substrate binding site [chemical binding]; other site 198214006234 hypothetical protein; Provisional; Region: PRK01821 198214006235 hypothetical protein; Provisional; Region: PRK10711 198214006236 cytidine deaminase; Provisional; Region: PRK09027 198214006237 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198214006238 active site 198214006239 catalytic motif [active] 198214006240 Zn binding site [ion binding]; other site 198214006241 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 198214006242 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198214006243 active site 198214006244 catalytic motif [active] 198214006245 Zn binding site [ion binding]; other site 198214006246 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198214006247 putative active site [active] 198214006248 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 198214006249 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 198214006250 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 198214006251 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 198214006252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198214006253 NAD binding site [chemical binding]; other site 198214006254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214006255 Similar to Escherichia coli K12 oxidoreductase gi: 1788469 (414 aa). BLAST with identity of 98% in 395 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006256 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214006257 TM-ABC transporter signature motif; other site 198214006258 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198214006259 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 198214006260 Walker A/P-loop; other site 198214006261 ATP binding site [chemical binding]; other site 198214006262 Q-loop/lid; other site 198214006263 ABC transporter signature motif; other site 198214006264 Walker B; other site 198214006265 D-loop; other site 198214006266 H-loop/switch region; other site 198214006267 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198214006268 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 198214006269 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 198214006270 ligand binding site [chemical binding]; other site 198214006271 calcium binding site [ion binding]; other site 198214006272 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 198214006273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214006274 DNA binding site [nucleotide binding] 198214006275 domain linker motif; other site 198214006276 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198214006277 dimerization interface (closed form) [polypeptide binding]; other site 198214006278 ligand binding site [chemical binding]; other site 198214006279 Predicted membrane protein [Function unknown]; Region: COG2311 198214006280 hypothetical protein; Provisional; Region: PRK10835 198214006281 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 198214006282 homodecamer interface [polypeptide binding]; other site 198214006283 active site 198214006284 putative catalytic site residues [active] 198214006285 zinc binding site [ion binding]; other site 198214006286 GTP-CH-I/GFRP interaction surface; other site 198214006287 Similar to Escherichia coli K12 esterase gi: 1788477 (279 aa). BLAST with identity of 98% in 280 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214006288 Similar to Escherichia coli K12 outer membrane receptor for iron-regulated colicin I receptor; porin; requires tonB gene product gi: 1788478 (664 aa). BLAST with identity of 99% in 663 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006289 lysine transporter; Provisional; Region: PRK10836 198214006290 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214006291 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 198214006292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214006293 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 198214006294 putative dimerization interface [polypeptide binding]; other site 198214006295 conserved hypothetical integral membrane protein; Region: TIGR00698 198214006296 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 198214006297 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 198214006298 AP (apurinic/apyrimidinic) site pocket; other site 198214006299 DNA interaction; other site 198214006300 Metal-binding active site; metal-binding site 198214006301 putative kinase; Provisional; Region: PRK09954 198214006302 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 198214006303 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 198214006304 substrate binding site [chemical binding]; other site 198214006305 ATP binding site [chemical binding]; other site 198214006306 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198214006307 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198214006308 Nucleoside recognition; Region: Gate; pfam07670 198214006309 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198214006310 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198214006311 active site 198214006312 tetramer interface [polypeptide binding]; other site 198214006313 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 198214006314 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198214006315 ligand binding site [chemical binding]; other site 198214006316 flexible hinge region; other site 198214006317 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198214006318 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198214006319 Nucleoside recognition; Region: Gate; pfam07670 198214006320 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198214006321 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 198214006322 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 198214006323 substrate binding site [chemical binding]; other site 198214006324 ATP binding site [chemical binding]; other site 198214006325 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 198214006326 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 198214006327 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198214006328 active site 198214006329 P-loop; other site 198214006330 phosphorylation site [posttranslational modification] 198214006331 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 198214006332 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 198214006333 putative substrate binding site [chemical binding]; other site 198214006334 putative ATP binding site [chemical binding]; other site 198214006335 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 198214006336 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214006337 active site 198214006338 phosphorylation site [posttranslational modification] 198214006339 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198214006340 dimerization domain swap beta strand [polypeptide binding]; other site 198214006341 regulatory protein interface [polypeptide binding]; other site 198214006342 active site 198214006343 regulatory phosphorylation site [posttranslational modification]; other site 198214006344 sugar efflux transporter B; Provisional; Region: PRK15011 198214006345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214006346 putative substrate translocation pore; other site 198214006347 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006349 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006350 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006351 elongation factor P; Provisional; Region: PRK04542 198214006352 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 198214006353 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 198214006354 RNA binding site [nucleotide binding]; other site 198214006355 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 198214006356 RNA binding site [nucleotide binding]; other site 198214006357 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 198214006358 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198214006359 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198214006360 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 198214006361 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 198214006362 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 198214006363 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198214006364 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 198214006365 active site 198214006366 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 198214006367 NlpC/P60 family; Region: NLPC_P60; pfam00877 198214006368 phage resistance protein; Provisional; Region: PRK10551 198214006369 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198214006370 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198214006371 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198214006372 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 198214006373 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 198214006374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214006375 dimer interface [polypeptide binding]; other site 198214006376 conserved gate region; other site 198214006377 putative PBP binding loops; other site 198214006378 ABC-ATPase subunit interface; other site 198214006379 microcin C ABC transporter permease; Provisional; Region: PRK15021 198214006380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214006381 dimer interface [polypeptide binding]; other site 198214006382 conserved gate region; other site 198214006383 putative PBP binding loops; other site 198214006384 ABC-ATPase subunit interface; other site 198214006385 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 198214006386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214006387 Walker A/P-loop; other site 198214006388 ATP binding site [chemical binding]; other site 198214006389 Q-loop/lid; other site 198214006390 ABC transporter signature motif; other site 198214006391 Walker B; other site 198214006392 D-loop; other site 198214006393 H-loop/switch region; other site 198214006394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214006395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214006396 Walker A/P-loop; other site 198214006397 ATP binding site [chemical binding]; other site 198214006398 Q-loop/lid; other site 198214006399 ABC transporter signature motif; other site 198214006400 Walker B; other site 198214006401 D-loop; other site 198214006402 H-loop/switch region; other site 198214006403 hypothetical protein; Provisional; Region: PRK11835 198214006404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214006405 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 198214006406 putative substrate translocation pore; other site 198214006407 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 198214006408 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214006409 RNA binding surface [nucleotide binding]; other site 198214006410 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 198214006411 active site 198214006412 uracil binding [chemical binding]; other site 198214006413 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 198214006414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214006415 ATP binding site [chemical binding]; other site 198214006416 putative Mg++ binding site [ion binding]; other site 198214006417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214006418 nucleotide binding region [chemical binding]; other site 198214006419 ATP-binding site [chemical binding]; other site 198214006420 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 198214006421 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 198214006422 5S rRNA interface [nucleotide binding]; other site 198214006423 CTC domain interface [polypeptide binding]; other site 198214006424 L16 interface [polypeptide binding]; other site 198214006425 nucleoid-associated protein NdpA; Validated; Region: PRK00378 198214006426 hypothetical protein; Provisional; Region: PRK13689 198214006427 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 198214006428 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 198214006429 Sulfatase; Region: Sulfatase; pfam00884 198214006430 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 198214006431 hypothetical protein; Provisional; Region: PRK09945 198214006432 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198214006433 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214006434 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198214006435 transcriptional regulator NarP; Provisional; Region: PRK10403 198214006436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006437 active site 198214006438 phosphorylation site [posttranslational modification] 198214006439 intermolecular recognition site; other site 198214006440 dimerization interface [polypeptide binding]; other site 198214006441 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214006442 DNA binding residues [nucleotide binding] 198214006443 dimerization interface [polypeptide binding]; other site 198214006444 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 198214006445 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 198214006446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198214006447 binding surface 198214006448 TPR motif; other site 198214006449 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 198214006450 catalytic residues [active] 198214006451 central insert; other site 198214006452 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 198214006453 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 198214006454 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 198214006455 heme exporter protein CcmC; Region: ccmC; TIGR01191 198214006456 heme exporter protein CcmB; Region: ccmB; TIGR01190 198214006457 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 198214006458 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 198214006459 Walker A/P-loop; other site 198214006460 ATP binding site [chemical binding]; other site 198214006461 Q-loop/lid; other site 198214006462 ABC transporter signature motif; other site 198214006463 Walker B; other site 198214006464 D-loop; other site 198214006465 H-loop/switch region; other site 198214006466 cytochrome c-type protein NapC; Provisional; Region: PRK10617 198214006467 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 198214006468 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 198214006469 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 198214006470 4Fe-4S binding domain; Region: Fer4_5; pfam12801 198214006471 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214006472 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 198214006473 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214006474 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214006475 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214006476 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 198214006477 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 198214006478 [4Fe-4S] binding site [ion binding]; other site 198214006479 molybdopterin cofactor binding site; other site 198214006480 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 198214006481 molybdopterin cofactor binding site; other site 198214006482 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 198214006483 ferredoxin-type protein; Provisional; Region: PRK10194 198214006484 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214006485 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 198214006486 secondary substrate binding site; other site 198214006487 primary substrate binding site; other site 198214006488 inhibition loop; other site 198214006489 dimerization interface [polypeptide binding]; other site 198214006490 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788539 (549 aa). BLAST with identity of 97% in 541 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006491 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 198214006492 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 198214006493 Walker A/P-loop; other site 198214006494 ATP binding site [chemical binding]; other site 198214006495 Q-loop/lid; other site 198214006496 ABC transporter signature motif; other site 198214006497 Walker B; other site 198214006498 D-loop; other site 198214006499 H-loop/switch region; other site 198214006500 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 198214006501 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 198214006502 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 198214006503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214006504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214006505 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 198214006506 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198214006507 DNA binding site [nucleotide binding] 198214006508 active site 198214006509 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 198214006510 outer membrane porin protein C; Provisional; Region: PRK10554 198214006511 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 198214006512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214006513 ATP binding site [chemical binding]; other site 198214006514 Mg2+ binding site [ion binding]; other site 198214006515 G-X-G motif; other site 198214006516 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198214006517 putative binding surface; other site 198214006518 active site 198214006519 transcriptional regulator RcsB; Provisional; Region: PRK10840 198214006520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006521 active site 198214006522 phosphorylation site [posttranslational modification] 198214006523 intermolecular recognition site; other site 198214006524 dimerization interface [polypeptide binding]; other site 198214006525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214006526 DNA binding residues [nucleotide binding] 198214006527 dimerization interface [polypeptide binding]; other site 198214006528 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 198214006529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214006530 dimer interface [polypeptide binding]; other site 198214006531 phosphorylation site [posttranslational modification] 198214006532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214006533 ATP binding site [chemical binding]; other site 198214006534 Mg2+ binding site [ion binding]; other site 198214006535 G-X-G motif; other site 198214006536 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 198214006537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006538 active site 198214006539 phosphorylation site [posttranslational modification] 198214006540 intermolecular recognition site; other site 198214006541 dimerization interface [polypeptide binding]; other site 198214006542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 198214006543 Predicted secreted protein [Function unknown]; Region: COG5445 198214006544 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 198214006545 Predicted secreted protein [Function unknown]; Region: COG5445 198214006546 Stage II sporulation protein; Region: SpoIID; pfam08486 198214006547 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 198214006548 Similar to Escherichia coli K12 membrane protein gi: 1788559 (1338 aa). BLAST with identity of 98% in 1755 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214006549 putative transposase OrfB; Reviewed; Region: PHA02517 198214006550 HTH-like domain; Region: HTH_21; pfam13276 198214006551 Integrase core domain; Region: rve; pfam00665 198214006552 Integrase core domain; Region: rve_3; pfam13683 198214006553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214006554 Transposase; Region: HTH_Tnp_1; cl17663 198214006555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 198214006556 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788561 (579 aa). BLAST with identity of 98% in 578 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006557 DNA gyrase subunit A; Validated; Region: PRK05560 198214006558 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198214006559 CAP-like domain; other site 198214006560 active site 198214006561 primary dimer interface [polypeptide binding]; other site 198214006562 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198214006563 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198214006564 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198214006565 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198214006566 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198214006567 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198214006568 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 198214006569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214006570 S-adenosylmethionine binding site [chemical binding]; other site 198214006571 Similar to Escherichia coli K12 ATP-binding component of a transport system gi: 1788565 (1251 aa). BLAST with identity of 96% in 1688 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214006572 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214006573 HTH-like domain; Region: HTH_21; pfam13276 198214006574 Integrase core domain; Region: rve; pfam00665 198214006575 Integrase core domain; Region: rve_3; pfam13683 198214006576 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 198214006577 ATP cone domain; Region: ATP-cone; pfam03477 198214006578 Class I ribonucleotide reductase; Region: RNR_I; cd01679 198214006579 active site 198214006580 dimer interface [polypeptide binding]; other site 198214006581 catalytic residues [active] 198214006582 effector binding site; other site 198214006583 R2 peptide binding site; other site 198214006584 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 198214006585 dimer interface [polypeptide binding]; other site 198214006586 putative radical transfer pathway; other site 198214006587 diiron center [ion binding]; other site 198214006588 tyrosyl radical; other site 198214006589 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198214006590 catalytic loop [active] 198214006591 iron binding site [ion binding]; other site 198214006592 hypothetical protein; Provisional; Region: PRK09902 198214006593 hypothetical protein; Provisional; Region: PRK09729 198214006594 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 198214006595 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 198214006596 active site 198214006597 catalytic site [active] 198214006598 metal binding site [ion binding]; metal-binding site 198214006599 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 198214006600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214006601 putative substrate translocation pore; other site 198214006602 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 198214006603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214006604 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 198214006605 FAD binding domain; Region: FAD_binding_2; pfam00890 198214006606 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 198214006607 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198214006608 Cysteine-rich domain; Region: CCG; pfam02754 198214006609 Cysteine-rich domain; Region: CCG; pfam02754 198214006610 hypothetical protein; Provisional; Region: PRK09956 198214006611 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198214006612 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788578 (268 aa). BLAST with identity of 98% in 153 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214006613 hypothetical protein; Provisional; Region: PRK03673 198214006614 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 198214006615 putative MPT binding site; other site 198214006616 Competence-damaged protein; Region: CinA; cl00666 198214006617 YfaZ precursor; Region: YfaZ; pfam07437 198214006618 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 198214006619 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 198214006620 catalytic core [active] 198214006621 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 198214006622 inhibitor-cofactor binding pocket; inhibition site 198214006623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214006624 catalytic residue [active] 198214006625 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 198214006626 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 198214006627 Ligand binding site; other site 198214006628 Putative Catalytic site; other site 198214006629 DXD motif; other site 198214006630 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 198214006631 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 198214006632 putative active site [active] 198214006633 putative catalytic site [active] 198214006634 putative Zn binding site [ion binding]; other site 198214006635 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 198214006636 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 198214006637 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 198214006638 signal transduction protein PmrD; Provisional; Region: PRK15450 198214006639 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 198214006640 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 198214006641 acyl-activating enzyme (AAE) consensus motif; other site 198214006642 putative AMP binding site [chemical binding]; other site 198214006643 putative active site [active] 198214006644 putative CoA binding site [chemical binding]; other site 198214006645 O-succinylbenzoate synthase; Provisional; Region: PRK05105 198214006646 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 198214006647 active site 198214006648 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 198214006649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198214006650 substrate binding site [chemical binding]; other site 198214006651 oxyanion hole (OAH) forming residues; other site 198214006652 trimer interface [polypeptide binding]; other site 198214006653 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 198214006654 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 198214006655 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 198214006656 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 198214006657 dimer interface [polypeptide binding]; other site 198214006658 tetramer interface [polypeptide binding]; other site 198214006659 PYR/PP interface [polypeptide binding]; other site 198214006660 TPP binding site [chemical binding]; other site 198214006661 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 198214006662 TPP-binding site; other site 198214006663 isochorismate synthases; Region: isochor_syn; TIGR00543 198214006664 hypothetical protein; Provisional; Region: PRK10404 198214006665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214006666 Coenzyme A binding pocket [chemical binding]; other site 198214006667 ribonuclease BN; Region: true_RNase_BN; TIGR02649 198214006668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006669 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006670 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006671 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006672 Similar to Escherichia coli K12 aminopeptidase gi: 1788607 (326 aa). BLAST with identity of 96% in 213 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214006673 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 198214006674 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00200 198214006675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198214006676 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 198214006677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198214006678 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 198214006679 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 198214006680 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198214006681 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 198214006682 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 198214006683 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 198214006684 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214006685 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 198214006686 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 198214006687 NADH dehydrogenase subunit G; Validated; Region: PRK08166 198214006688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198214006689 catalytic loop [active] 198214006690 iron binding site [ion binding]; other site 198214006691 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 198214006692 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 198214006693 [4Fe-4S] binding site [ion binding]; other site 198214006694 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 198214006695 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 198214006696 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 198214006697 SLBB domain; Region: SLBB; pfam10531 198214006698 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 198214006699 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 198214006700 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 198214006701 putative dimer interface [polypeptide binding]; other site 198214006702 [2Fe-2S] cluster binding site [ion binding]; other site 198214006703 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 198214006704 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 198214006705 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 198214006706 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 198214006707 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 198214006708 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 198214006709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214006710 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 198214006711 putative dimerization interface [polypeptide binding]; other site 198214006712 aminotransferase AlaT; Validated; Region: PRK09265 198214006713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214006714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214006715 homodimer interface [polypeptide binding]; other site 198214006716 catalytic residue [active] 198214006717 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198214006718 Zn2+ binding site [ion binding]; other site 198214006719 Mg2+ binding site [ion binding]; other site 198214006720 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 198214006721 transmembrane helices; other site 198214006722 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198214006723 TrkA-C domain; Region: TrkA_C; pfam02080 198214006724 TrkA-C domain; Region: TrkA_C; pfam02080 198214006725 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 198214006726 putative phosphatase; Provisional; Region: PRK11587 198214006727 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198214006728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214006729 active site 198214006730 motif I; other site 198214006731 motif II; other site 198214006732 hypothetical protein; Validated; Region: PRK05445 198214006733 hypothetical protein; Provisional; Region: PRK01816 198214006734 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 198214006735 phosphate acetyltransferase; Reviewed; Region: PRK05632 198214006736 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198214006737 DRTGG domain; Region: DRTGG; pfam07085 198214006738 phosphate acetyltransferase; Region: pta; TIGR00651 198214006739 hypothetical protein; Provisional; Region: PRK11588 198214006740 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 198214006741 nudix motif; other site 198214006742 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 198214006743 active site 198214006744 metal binding site [ion binding]; metal-binding site 198214006745 homotetramer interface [polypeptide binding]; other site 198214006746 glutathione S-transferase; Provisional; Region: PRK15113 198214006747 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 198214006748 C-terminal domain interface [polypeptide binding]; other site 198214006749 GSH binding site (G-site) [chemical binding]; other site 198214006750 dimer interface [polypeptide binding]; other site 198214006751 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 198214006752 N-terminal domain interface [polypeptide binding]; other site 198214006753 putative dimer interface [polypeptide binding]; other site 198214006754 putative substrate binding pocket (H-site) [chemical binding]; other site 198214006755 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 198214006756 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 198214006757 C-terminal domain interface [polypeptide binding]; other site 198214006758 GSH binding site (G-site) [chemical binding]; other site 198214006759 dimer interface [polypeptide binding]; other site 198214006760 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 198214006761 N-terminal domain interface [polypeptide binding]; other site 198214006762 putative dimer interface [polypeptide binding]; other site 198214006763 active site 198214006764 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 198214006765 homooctamer interface [polypeptide binding]; other site 198214006766 active site 198214006767 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 198214006768 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 198214006769 putative NAD(P) binding site [chemical binding]; other site 198214006770 putative active site [active] 198214006771 putative transposase; Provisional; Region: PRK09857 198214006772 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198214006773 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 198214006774 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198214006775 Walker A/P-loop; other site 198214006776 ATP binding site [chemical binding]; other site 198214006777 Q-loop/lid; other site 198214006778 ABC transporter signature motif; other site 198214006779 Walker B; other site 198214006780 D-loop; other site 198214006781 H-loop/switch region; other site 198214006782 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 198214006783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214006784 dimer interface [polypeptide binding]; other site 198214006785 conserved gate region; other site 198214006786 putative PBP binding loops; other site 198214006787 ABC-ATPase subunit interface; other site 198214006788 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198214006789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214006790 dimer interface [polypeptide binding]; other site 198214006791 conserved gate region; other site 198214006792 putative PBP binding loops; other site 198214006793 ABC-ATPase subunit interface; other site 198214006794 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 198214006795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214006796 substrate binding pocket [chemical binding]; other site 198214006797 membrane-bound complex binding site; other site 198214006798 hinge residues; other site 198214006799 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 198214006800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214006801 substrate binding pocket [chemical binding]; other site 198214006802 membrane-bound complex binding site; other site 198214006803 hinge residues; other site 198214006804 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 198214006805 amidophosphoribosyltransferase; Provisional; Region: PRK09246 198214006806 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 198214006807 active site 198214006808 tetramer interface [polypeptide binding]; other site 198214006809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214006810 active site 198214006811 colicin V production protein; Provisional; Region: PRK10845 198214006812 cell division protein DedD; Provisional; Region: PRK11633 198214006813 Sporulation related domain; Region: SPOR; pfam05036 198214006814 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 198214006815 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198214006816 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198214006817 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 198214006818 hypothetical protein; Provisional; Region: PRK10847 198214006819 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 198214006820 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 198214006821 dimerization interface 3.5A [polypeptide binding]; other site 198214006822 active site 198214006823 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 198214006824 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 198214006825 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 198214006826 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 198214006827 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 198214006828 ligand binding site [chemical binding]; other site 198214006829 NAD binding site [chemical binding]; other site 198214006830 catalytic site [active] 198214006831 homodimer interface [polypeptide binding]; other site 198214006832 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 198214006833 putative transporter; Provisional; Region: PRK12382 198214006834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214006835 putative substrate translocation pore; other site 198214006836 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 198214006837 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198214006838 dimer interface [polypeptide binding]; other site 198214006839 active site 198214006840 Uncharacterized conserved protein [Function unknown]; Region: COG4121 198214006841 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 198214006842 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 198214006843 YfcL protein; Region: YfcL; pfam08891 198214006844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 198214006845 hypothetical protein; Provisional; Region: PRK10621 198214006846 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 198214006847 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 198214006848 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 198214006849 Tetramer interface [polypeptide binding]; other site 198214006850 active site 198214006851 FMN-binding site [chemical binding]; other site 198214006852 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 198214006853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214006854 S-adenosylmethionine binding site [chemical binding]; other site 198214006855 hypothetical protein; Provisional; Region: PRK04946 198214006856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 198214006857 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 198214006858 Fimbrial protein; Region: Fimbrial; cl01416 198214006859 Fimbrial protein; Region: Fimbrial; cl01416 198214006860 Fimbrial protein; Region: Fimbrial; cl01416 198214006861 Similar to Escherichia coli K12 chaperone gi: 1788677 (251 aa). BLAST with identity of 88% in 250 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214006862 Similar to Escherichia coli K12 outer membrane protein gi: 1788679 (579 aa). BLAST with identity of 97% in 577 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214006863 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198214006864 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214006865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214006866 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214006867 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214006868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198214006869 catalytic core [active] 198214006870 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 198214006871 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198214006872 substrate binding site [chemical binding]; other site 198214006873 oxyanion hole (OAH) forming residues; other site 198214006874 trimer interface [polypeptide binding]; other site 198214006875 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198214006876 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198214006877 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198214006878 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 198214006879 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198214006880 dimer interface [polypeptide binding]; other site 198214006881 active site 198214006882 conserved hypothetical protein; Region: TIGR00743 198214006883 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 198214006884 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214006885 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 198214006886 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198214006887 putative transposase OrfB; Reviewed; Region: PHA02517 198214006888 HTH-like domain; Region: HTH_21; pfam13276 198214006889 Integrase core domain; Region: rve; pfam00665 198214006890 Integrase core domain; Region: rve_3; pfam13683 198214006891 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 198214006892 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 198214006893 substrate binding [chemical binding]; other site 198214006894 active site 198214006895 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 198214006896 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214006897 DNA binding site [nucleotide binding] 198214006898 domain linker motif; other site 198214006899 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 198214006900 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 198214006901 putative dimerization interface [polypeptide binding]; other site 198214006902 putative ligand binding site [chemical binding]; other site 198214006903 fructuronate transporter; Provisional; Region: PRK10034; cl15264 198214006904 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 198214006905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198214006906 catalytic residue [active] 198214006907 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198214006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214006909 putative substrate translocation pore; other site 198214006910 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 198214006911 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214006912 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214006913 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 198214006914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006915 active site 198214006916 phosphorylation site [posttranslational modification] 198214006917 intermolecular recognition site; other site 198214006918 dimerization interface [polypeptide binding]; other site 198214006919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214006920 DNA binding residues [nucleotide binding] 198214006921 dimerization interface [polypeptide binding]; other site 198214006922 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 198214006923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214006924 substrate binding pocket [chemical binding]; other site 198214006925 membrane-bound complex binding site; other site 198214006926 hinge residues; other site 198214006927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214006928 substrate binding pocket [chemical binding]; other site 198214006929 membrane-bound complex binding site; other site 198214006930 hinge residues; other site 198214006931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214006932 dimer interface [polypeptide binding]; other site 198214006933 phosphorylation site [posttranslational modification] 198214006934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214006935 ATP binding site [chemical binding]; other site 198214006936 Mg2+ binding site [ion binding]; other site 198214006937 G-X-G motif; other site 198214006938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006939 active site 198214006940 phosphorylation site [posttranslational modification] 198214006941 intermolecular recognition site; other site 198214006942 dimerization interface [polypeptide binding]; other site 198214006943 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198214006944 putative binding surface; other site 198214006945 active site 198214006946 putative CoA-transferase; Provisional; Region: PRK11430 198214006947 putative transporter YfdV; Provisional; Region: PRK09903 198214006948 oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254 198214006949 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198214006950 PYR/PP interface [polypeptide binding]; other site 198214006951 dimer interface [polypeptide binding]; other site 198214006952 TPP binding site [chemical binding]; other site 198214006953 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198214006954 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 198214006955 TPP-binding site; other site 198214006956 dimer interface [polypeptide binding]; other site 198214006957 formyl-coenzyme A transferase; Provisional; Region: PRK05398 198214006958 hypothetical protein; Provisional; Region: PRK10316 198214006959 YfdX protein; Region: YfdX; pfam10938 198214006960 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 198214006961 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198214006962 putative acyl-acceptor binding pocket; other site 198214006963 aminotransferase; Validated; Region: PRK08175 198214006964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214006965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214006966 homodimer interface [polypeptide binding]; other site 198214006967 catalytic residue [active] 198214006968 Similar to Escherichia coli K12 sensor protein gi: 1788723 (566 aa). BLAST with identity of 99% in 496 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214006969 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 198214006970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214006971 active site 198214006972 phosphorylation site [posttranslational modification] 198214006973 intermolecular recognition site; other site 198214006974 dimerization interface [polypeptide binding]; other site 198214006975 LytTr DNA-binding domain; Region: LytTR; pfam04397 198214006976 Similar to Escherichia coli K12 ARAC-type regulatory protein gi: 1788725 (286 aa). BLAST with identity of 97% in 286 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214006977 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198214006978 dimerization domain swap beta strand [polypeptide binding]; other site 198214006979 regulatory protein interface [polypeptide binding]; other site 198214006980 active site 198214006981 regulatory phosphorylation site [posttranslational modification]; other site 198214006982 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 198214006983 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 198214006984 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198214006985 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198214006986 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214006987 active site 198214006988 phosphorylation site [posttranslational modification] 198214006989 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 198214006990 oligomer interface [polypeptide binding]; other site 198214006991 active site 198214006992 metal binding site [ion binding]; metal-binding site 198214006993 Similar to Escherichia coli K12 peptidase gi: 1788728 (362 aa). BLAST with identity of 96% in 361 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214006994 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 198214006995 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198214006996 active site 198214006997 P-loop; other site 198214006998 phosphorylation site [posttranslational modification] 198214006999 glucokinase; Provisional; Region: glk; PRK00292 198214007000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214007001 nucleotide binding site [chemical binding]; other site 198214007002 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 198214007003 Cl- selectivity filter; other site 198214007004 Cl- binding residues [ion binding]; other site 198214007005 pore gating glutamate residue; other site 198214007006 dimer interface [polypeptide binding]; other site 198214007007 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 198214007008 manganese transport protein MntH; Reviewed; Region: PRK00701 198214007009 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 198214007010 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198214007011 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198214007012 Nucleoside recognition; Region: Gate; pfam07670 198214007013 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198214007014 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788739 (769 aa). BLAST with identity of 99% in 639 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214007015 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 198214007016 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 198214007017 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 198214007018 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 198214007019 active site 198214007020 HIGH motif; other site 198214007021 KMSKS motif; other site 198214007022 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 198214007023 FlxA-like protein; Region: FlxA; pfam14282 198214007024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198214007025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214007026 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 198214007027 putative dimerization interface [polypeptide binding]; other site 198214007028 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 198214007029 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 198214007030 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 198214007031 nucleotide binding pocket [chemical binding]; other site 198214007032 K-X-D-G motif; other site 198214007033 catalytic site [active] 198214007034 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 198214007035 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 198214007036 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 198214007037 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 198214007038 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 198214007039 Dimer interface [polypeptide binding]; other site 198214007040 BRCT sequence motif; other site 198214007041 cell division protein ZipA; Provisional; Region: PRK03427 198214007042 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 198214007043 FtsZ protein binding site [polypeptide binding]; other site 198214007044 putative sulfate transport protein CysZ; Validated; Region: PRK04949 198214007045 cysteine synthase; Region: PLN02565 198214007046 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198214007047 dimer interface [polypeptide binding]; other site 198214007048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214007049 catalytic residue [active] 198214007050 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198214007051 dimerization domain swap beta strand [polypeptide binding]; other site 198214007052 regulatory protein interface [polypeptide binding]; other site 198214007053 active site 198214007054 regulatory phosphorylation site [posttranslational modification]; other site 198214007055 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 198214007056 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 198214007057 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198214007058 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198214007059 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198214007060 HPr interaction site; other site 198214007061 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198214007062 active site 198214007063 phosphorylation site [posttranslational modification] 198214007064 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 198214007065 dimer interface [polypeptide binding]; other site 198214007066 pyridoxal binding site [chemical binding]; other site 198214007067 ATP binding site [chemical binding]; other site 198214007068 hypothetical protein; Provisional; Region: PRK10318 198214007069 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788760 (245 aa). BLAST with identity of 96% in 241 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007070 cysteine synthase; Region: PLN02565 198214007071 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198214007072 dimer interface [polypeptide binding]; other site 198214007073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214007074 catalytic residue [active] 198214007075 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 198214007076 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 198214007077 Walker A/P-loop; other site 198214007078 ATP binding site [chemical binding]; other site 198214007079 Q-loop/lid; other site 198214007080 ABC transporter signature motif; other site 198214007081 Walker B; other site 198214007082 D-loop; other site 198214007083 H-loop/switch region; other site 198214007084 TOBE-like domain; Region: TOBE_3; pfam12857 198214007085 Similar to Escherichia coli K12 sulfate transport system permease W protein gi: 1788762 (150 aa). BLAST with identity of 95% in 149 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007086 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198214007087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214007088 dimer interface [polypeptide binding]; other site 198214007089 conserved gate region; other site 198214007090 putative PBP binding loops; other site 198214007091 ABC-ATPase subunit interface; other site 198214007092 thiosulfate transporter subunit; Provisional; Region: PRK10852 198214007093 short chain dehydrogenase; Provisional; Region: PRK08226 198214007094 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 198214007095 NAD binding site [chemical binding]; other site 198214007096 homotetramer interface [polypeptide binding]; other site 198214007097 homodimer interface [polypeptide binding]; other site 198214007098 active site 198214007099 transcriptional regulator MurR; Provisional; Region: PRK15482 198214007100 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198214007101 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198214007102 putative active site [active] 198214007103 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 198214007104 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 198214007105 putative active site [active] 198214007106 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 198214007107 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198214007108 active site turn [active] 198214007109 phosphorylation site [posttranslational modification] 198214007110 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198214007111 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 198214007112 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 198214007113 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 198214007114 putative acetyltransferase; Provisional; Region: PRK03624 198214007115 Uncharacterized conserved protein [Function unknown]; Region: COG3375 198214007116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214007117 Coenzyme A binding pocket [chemical binding]; other site 198214007118 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 198214007119 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198214007120 active site 198214007121 metal binding site [ion binding]; metal-binding site 198214007122 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 198214007123 Similar to Escherichia coli K12 ARAC-type regulatory protein gi: 1788778 (351 aa). BLAST with identity of 96% in 350 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214007124 carboxysome structural protein EutK; Provisional; Region: PRK15466 198214007125 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 198214007126 Hexamer interface [polypeptide binding]; other site 198214007127 Hexagonal pore residue; other site 198214007128 EAP30/Vps36 family; Region: EAP30; pfam04157 198214007129 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 198214007130 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 198214007131 Hexamer interface [polypeptide binding]; other site 198214007132 Hexagonal pore residue; other site 198214007133 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 198214007134 putative hexamer interface [polypeptide binding]; other site 198214007135 putative hexagonal pore; other site 198214007136 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 198214007137 HNH endonuclease; Region: HNH_3; pfam13392 198214007138 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 198214007139 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 198214007140 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 198214007141 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214007142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214007143 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214007144 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214007145 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 198214007146 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 198214007147 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 198214007148 G1 box; other site 198214007149 GTP/Mg2+ binding site [chemical binding]; other site 198214007150 G2 box; other site 198214007151 Switch I region; other site 198214007152 G3 box; other site 198214007153 Switch II region; other site 198214007154 G4 box; other site 198214007155 G5 box; other site 198214007156 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 198214007157 putative hexamer interface [polypeptide binding]; other site 198214007158 putative hexagonal pore; other site 198214007159 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 198214007160 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198214007161 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 198214007162 putative NAD(P) binding site [chemical binding]; other site 198214007163 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 198214007164 transaldolase-like protein; Provisional; Region: PTZ00411 198214007165 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 198214007166 active site 198214007167 dimer interface [polypeptide binding]; other site 198214007168 catalytic residue [active] 198214007169 transketolase; Reviewed; Region: PRK12753 198214007170 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198214007171 TPP-binding site [chemical binding]; other site 198214007172 dimer interface [polypeptide binding]; other site 198214007173 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198214007174 PYR/PP interface [polypeptide binding]; other site 198214007175 dimer interface [polypeptide binding]; other site 198214007176 TPP binding site [chemical binding]; other site 198214007177 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198214007178 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 198214007179 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 198214007180 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198214007181 dimer interface [polypeptide binding]; other site 198214007182 ADP-ribose binding site [chemical binding]; other site 198214007183 active site 198214007184 nudix motif; other site 198214007185 metal binding site [ion binding]; metal-binding site 198214007186 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 198214007187 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214007188 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 198214007189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214007190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214007191 'Similar to Escherichia coli K12 sensor for nitrate reductase system, protein histidine kinase (acts on NarP and narL) gi: 1788812 (567 aa). BLAST with identity of 97% in 563 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214007192 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 198214007193 MMPL family; Region: MMPL; cl14618 198214007194 MMPL family; Region: MMPL; cl14618 198214007195 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 198214007196 putative catalytic residues [active] 198214007197 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 198214007198 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 198214007199 metal binding site [ion binding]; metal-binding site 198214007200 dimer interface [polypeptide binding]; other site 198214007201 hypothetical protein; Provisional; Region: PRK13664 198214007202 putative hydrolase; Provisional; Region: PRK11460 198214007203 Predicted esterase [General function prediction only]; Region: COG0400 198214007204 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 198214007205 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 198214007206 Helicase; Region: Helicase_RecD; pfam05127 198214007207 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 198214007208 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 198214007209 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 198214007210 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 198214007211 ATP binding site [chemical binding]; other site 198214007212 active site 198214007213 substrate binding site [chemical binding]; other site 198214007214 lipoprotein; Provisional; Region: PRK11679 198214007215 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 198214007216 dimer interface [polypeptide binding]; other site 198214007217 active site 198214007218 catalytic residue [active] 198214007219 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 198214007220 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 198214007221 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 198214007222 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 198214007223 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 198214007224 catalytic triad [active] 198214007225 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198214007226 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214007227 Similar to Escherichia coli K12 hydrogenase 4 membrane subunit gi: 1788827 (673 aa). BLAST with identity of 98% in 673 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007228 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 198214007229 hydrogenase 4 subunit D; Validated; Region: PRK06525 198214007230 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198214007231 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 198214007232 hydrogenase 4 subunit F; Validated; Region: PRK06458 198214007233 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198214007234 hydrogenase 4 subunit H; Validated; Region: PRK08222 198214007235 4Fe-4S binding domain; Region: Fer4; pfam00037 198214007236 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 198214007237 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 198214007238 Similar to Escherichia coli K12 probable formate transporter (formate channel 2) gi: 1788837 (283 aa). BLAST with identity of 98% in 291 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214007239 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198214007240 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 198214007241 Peptidase family M48; Region: Peptidase_M48; cl12018 198214007242 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 198214007243 catalytic residues [active] 198214007244 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 198214007245 DNA replication initiation factor; Provisional; Region: PRK08084 198214007246 uracil transporter; Provisional; Region: PRK10720 198214007247 uracil-xanthine permease; Region: ncs2; TIGR00801 198214007248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214007249 active site 198214007250 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 198214007251 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 198214007252 dimerization interface [polypeptide binding]; other site 198214007253 putative ATP binding site [chemical binding]; other site 198214007254 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 198214007255 active site 198214007256 substrate binding site [chemical binding]; other site 198214007257 cosubstrate binding site; other site 198214007258 catalytic site [active] 198214007259 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 198214007260 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 198214007261 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 198214007262 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 198214007263 domain interface [polypeptide binding]; other site 198214007264 active site 198214007265 catalytic site [active] 198214007266 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 198214007267 domain interface [polypeptide binding]; other site 198214007268 active site 198214007269 catalytic site [active] 198214007270 exopolyphosphatase; Provisional; Region: PRK10854 198214007271 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 198214007272 Similar to Escherichia coli K12 cytochrome C-type biogenesis protein gi: 1788849 (748 aa). BLAST with identity of 99% in 1170 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214007273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214007274 Transposase; Region: HTH_Tnp_1; pfam01527 198214007275 putative transposase OrfB; Reviewed; Region: PHA02517 198214007276 HTH-like domain; Region: HTH_21; pfam13276 198214007277 Integrase core domain; Region: rve; pfam00665 198214007278 Integrase core domain; Region: rve_3; pfam13683 198214007279 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 198214007280 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 198214007281 GMP synthase; Reviewed; Region: guaA; PRK00074 198214007282 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 198214007283 AMP/PPi binding site [chemical binding]; other site 198214007284 candidate oxyanion hole; other site 198214007285 catalytic triad [active] 198214007286 potential glutamine specificity residues [chemical binding]; other site 198214007287 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 198214007288 ATP Binding subdomain [chemical binding]; other site 198214007289 Ligand Binding sites [chemical binding]; other site 198214007290 Dimerization subdomain; other site 198214007291 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 198214007292 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198214007293 active site 198214007294 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 198214007295 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 198214007296 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 198214007297 generic binding surface II; other site 198214007298 generic binding surface I; other site 198214007299 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 198214007300 GTP-binding protein Der; Reviewed; Region: PRK00093 198214007301 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 198214007302 G1 box; other site 198214007303 GTP/Mg2+ binding site [chemical binding]; other site 198214007304 Switch I region; other site 198214007305 G2 box; other site 198214007306 Switch II region; other site 198214007307 G3 box; other site 198214007308 G4 box; other site 198214007309 G5 box; other site 198214007310 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 198214007311 G1 box; other site 198214007312 GTP/Mg2+ binding site [chemical binding]; other site 198214007313 Switch I region; other site 198214007314 G2 box; other site 198214007315 G3 box; other site 198214007316 Switch II region; other site 198214007317 G4 box; other site 198214007318 G5 box; other site 198214007319 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 198214007320 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 198214007321 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 198214007322 Trp docking motif [polypeptide binding]; other site 198214007323 active site 198214007324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 198214007325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 198214007326 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 198214007327 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 198214007328 dimer interface [polypeptide binding]; other site 198214007329 motif 1; other site 198214007330 active site 198214007331 motif 2; other site 198214007332 motif 3; other site 198214007333 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 198214007334 anticodon binding site; other site 198214007335 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 198214007336 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 198214007337 cytoskeletal protein RodZ; Provisional; Region: PRK10856 198214007338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214007339 non-specific DNA binding site [nucleotide binding]; other site 198214007340 salt bridge; other site 198214007341 sequence-specific DNA binding site [nucleotide binding]; other site 198214007342 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 198214007343 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 198214007344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214007345 FeS/SAM binding site; other site 198214007346 Nucleoside diphosphate kinase; Region: NDK; pfam00334 198214007347 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 198214007348 active site 198214007349 multimer interface [polypeptide binding]; other site 198214007350 Transglycosylase; Region: Transgly; pfam00912 198214007351 penicillin-binding protein 1C; Provisional; Region: PRK11240 198214007352 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198214007353 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 198214007354 Similar to Escherichia coli K12 thiosulfate sulfurtransferase gi: 1788869 (335 aa). BLAST with identity of 98% in 161 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214007355 SseB protein N-terminal domain; Region: SseB; pfam07179 198214007356 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 198214007357 SseB protein C-terminal domain; Region: SseB_C; pfam14581 198214007358 aminopeptidase B; Provisional; Region: PRK05015 198214007359 Peptidase; Region: DUF3663; pfam12404 198214007360 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 198214007361 interface (dimer of trimers) [polypeptide binding]; other site 198214007362 Substrate-binding/catalytic site; other site 198214007363 Zn-binding sites [ion binding]; other site 198214007364 hypothetical protein; Provisional; Region: PRK10721 198214007365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198214007366 catalytic loop [active] 198214007367 iron binding site [ion binding]; other site 198214007368 chaperone protein HscA; Provisional; Region: hscA; PRK05183 198214007369 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 198214007370 nucleotide binding site [chemical binding]; other site 198214007371 putative NEF/HSP70 interaction site [polypeptide binding]; other site 198214007372 SBD interface [polypeptide binding]; other site 198214007373 co-chaperone HscB; Provisional; Region: hscB; PRK05014 198214007374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198214007375 HSP70 interaction site [polypeptide binding]; other site 198214007376 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 198214007377 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 198214007378 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 198214007379 trimerization site [polypeptide binding]; other site 198214007380 active site 198214007381 cysteine desulfurase; Provisional; Region: PRK14012 198214007382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198214007383 catalytic residue [active] 198214007384 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 198214007385 Rrf2 family protein; Region: rrf2_super; TIGR00738 198214007386 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 198214007387 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 198214007388 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 198214007389 active site 198214007390 dimerization interface [polypeptide binding]; other site 198214007391 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 198214007392 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198214007393 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 198214007394 PRD domain; Region: PRD; pfam00874 198214007395 PRD domain; Region: PRD; pfam00874 198214007396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214007397 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 198214007398 putative substrate translocation pore; other site 198214007399 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 198214007400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214007401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214007402 dimerization interface [polypeptide binding]; other site 198214007403 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 198214007404 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 198214007405 iron-sulfur cluster [ion binding]; other site 198214007406 [2Fe-2S] cluster binding site [ion binding]; other site 198214007407 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 198214007408 beta subunit interface [polypeptide binding]; other site 198214007409 alpha subunit interface [polypeptide binding]; other site 198214007410 active site 198214007411 substrate binding site [chemical binding]; other site 198214007412 Fe binding site [ion binding]; other site 198214007413 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 198214007414 inter-subunit interface; other site 198214007415 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 198214007416 [2Fe-2S] cluster binding site [ion binding]; other site 198214007417 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 198214007418 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 198214007419 NAD binding site [chemical binding]; other site 198214007420 active site 198214007421 Similar to Escherichia coli K12 ferredoxin reductase subunit of phenylpropionate dioxygenase gi: 1788892 (401 aa). BLAST with identity of 99% in 408 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007422 Predicted membrane protein [Function unknown]; Region: COG2259 198214007423 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 198214007424 active site 198214007425 catalytic residues [active] 198214007426 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 198214007427 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198214007428 putative NAD(P) binding site [chemical binding]; other site 198214007429 catalytic Zn binding site [ion binding]; other site 198214007430 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214007431 TM-ABC transporter signature motif; other site 198214007432 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198214007433 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198214007434 Walker A/P-loop; other site 198214007435 ATP binding site [chemical binding]; other site 198214007436 Q-loop/lid; other site 198214007437 ABC transporter signature motif; other site 198214007438 Walker B; other site 198214007439 D-loop; other site 198214007440 H-loop/switch region; other site 198214007441 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198214007442 Similar to Escherichia coli K12 LACI-type transcriptional regulator gi: 1788898 (328 aa). BLAST with identity of 97% in 327 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007443 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 198214007444 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198214007445 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214007446 nucleotide binding site [chemical binding]; other site 198214007447 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 198214007448 dimer interface [polypeptide binding]; other site 198214007449 active site 198214007450 glycine-pyridoxal phosphate binding site [chemical binding]; other site 198214007451 folate binding site [chemical binding]; other site 198214007452 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 198214007453 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 198214007454 heme-binding site [chemical binding]; other site 198214007455 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 198214007456 FAD binding pocket [chemical binding]; other site 198214007457 FAD binding motif [chemical binding]; other site 198214007458 phosphate binding motif [ion binding]; other site 198214007459 beta-alpha-beta structure motif; other site 198214007460 NAD binding pocket [chemical binding]; other site 198214007461 Heme binding pocket [chemical binding]; other site 198214007462 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 198214007463 response regulator GlrR; Provisional; Region: PRK15115 198214007464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214007465 active site 198214007466 phosphorylation site [posttranslational modification] 198214007467 intermolecular recognition site; other site 198214007468 dimerization interface [polypeptide binding]; other site 198214007469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214007470 Walker A motif; other site 198214007471 ATP binding site [chemical binding]; other site 198214007472 Walker B motif; other site 198214007473 arginine finger; other site 198214007474 hypothetical protein; Provisional; Region: PRK10722 198214007475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198214007476 HAMP domain; Region: HAMP; pfam00672 198214007477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214007478 dimer interface [polypeptide binding]; other site 198214007479 phosphorylation site [posttranslational modification] 198214007480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214007481 ATP binding site [chemical binding]; other site 198214007482 Mg2+ binding site [ion binding]; other site 198214007483 G-X-G motif; other site 198214007484 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 198214007485 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 198214007486 dimerization interface [polypeptide binding]; other site 198214007487 ATP binding site [chemical binding]; other site 198214007488 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 198214007489 dimerization interface [polypeptide binding]; other site 198214007490 ATP binding site [chemical binding]; other site 198214007491 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 198214007492 putative active site [active] 198214007493 catalytic triad [active] 198214007494 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 198214007495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214007496 substrate binding pocket [chemical binding]; other site 198214007497 membrane-bound complex binding site; other site 198214007498 hinge residues; other site 198214007499 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214007500 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214007501 catalytic residue [active] 198214007502 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 198214007503 nucleoside/Zn binding site; other site 198214007504 dimer interface [polypeptide binding]; other site 198214007505 catalytic motif [active] 198214007506 hypothetical protein; Provisional; Region: PRK11590 198214007507 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198214007508 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 198214007509 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198214007510 putative active site [active] 198214007511 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 198214007512 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 198214007513 catalytic residues [active] 198214007514 catalytic nucleophile [active] 198214007515 Presynaptic Site I dimer interface [polypeptide binding]; other site 198214007516 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 198214007517 Synaptic Flat tetramer interface [polypeptide binding]; other site 198214007518 Synaptic Site I dimer interface [polypeptide binding]; other site 198214007519 DNA binding site [nucleotide binding] 198214007520 ipaH island V 198214007521 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214007522 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198214007523 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198214007524 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214007525 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 198214007526 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198214007527 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 198214007528 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214007529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214007530 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214007531 HTH-like domain; Region: HTH_21; pfam13276 198214007532 Integrase core domain; Region: rve; pfam00665 198214007533 Integrase core domain; Region: rve_3; pfam13683 198214007534 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 198214007535 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 198214007536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214007537 Transposase; Region: HTH_Tnp_1; pfam01527 198214007538 HTH-like domain; Region: HTH_21; pfam13276 198214007539 Integrase core domain; Region: rve; pfam00665 198214007540 Integrase core domain; Region: rve_3; pfam13683 198214007541 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 198214007542 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 198214007543 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 198214007544 active site 198214007545 hydrophilic channel; other site 198214007546 dimerization interface [polypeptide binding]; other site 198214007547 catalytic residues [active] 198214007548 active site lid [active] 198214007549 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 198214007550 Recombination protein O N terminal; Region: RecO_N; pfam11967 198214007551 Recombination protein O C terminal; Region: RecO_C; pfam02565 198214007552 GTPase Era; Reviewed; Region: era; PRK00089 198214007553 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 198214007554 G1 box; other site 198214007555 GTP/Mg2+ binding site [chemical binding]; other site 198214007556 Switch I region; other site 198214007557 G2 box; other site 198214007558 Switch II region; other site 198214007559 G3 box; other site 198214007560 G4 box; other site 198214007561 G5 box; other site 198214007562 KH domain; Region: KH_2; pfam07650 198214007563 ribonuclease III; Reviewed; Region: rnc; PRK00102 198214007564 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 198214007565 dimerization interface [polypeptide binding]; other site 198214007566 active site 198214007567 metal binding site [ion binding]; metal-binding site 198214007568 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 198214007569 dsRNA binding site [nucleotide binding]; other site 198214007570 signal peptidase I; Provisional; Region: PRK10861 198214007571 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198214007572 Catalytic site [active] 198214007573 GTP-binding protein LepA; Provisional; Region: PRK05433 198214007574 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 198214007575 G1 box; other site 198214007576 putative GEF interaction site [polypeptide binding]; other site 198214007577 GTP/Mg2+ binding site [chemical binding]; other site 198214007578 Switch I region; other site 198214007579 G2 box; other site 198214007580 G3 box; other site 198214007581 Switch II region; other site 198214007582 G4 box; other site 198214007583 G5 box; other site 198214007584 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 198214007585 Elongation Factor G, domain II; Region: EFG_II; pfam14492 198214007586 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 198214007587 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 198214007588 SoxR reducing system protein RseC; Provisional; Region: PRK10862 198214007589 anti-sigma E factor; Provisional; Region: rseB; PRK09455 198214007590 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 198214007591 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 198214007592 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 198214007593 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 198214007594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198214007595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198214007596 DNA binding residues [nucleotide binding] 198214007597 'Similar to Escherichia coli K12 quinolinate synthetase, B protein gi: 1788928 (541 aa). BLAST with identity of 97% in 541 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214007598 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 198214007599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214007600 S-adenosylmethionine binding site [chemical binding]; other site 198214007601 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 198214007602 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198214007603 ATP binding site [chemical binding]; other site 198214007604 Mg++ binding site [ion binding]; other site 198214007605 motif III; other site 198214007606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214007607 nucleotide binding region [chemical binding]; other site 198214007608 ATP-binding site [chemical binding]; other site 198214007609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198214007610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214007611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198214007612 dimerization interface [polypeptide binding]; other site 198214007613 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 198214007614 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 198214007615 putative methyltransferase; Provisional; Region: PRK10864 198214007616 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 198214007617 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198214007618 thioredoxin 2; Provisional; Region: PRK10996 198214007619 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 198214007620 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198214007621 catalytic residues [active] 198214007622 Uncharacterized conserved protein [Function unknown]; Region: COG3148 198214007623 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 198214007624 CoA binding domain; Region: CoA_binding_2; pfam13380 198214007625 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 198214007626 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 198214007627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198214007628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198214007629 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 198214007630 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 198214007631 domain interface [polypeptide binding]; other site 198214007632 putative active site [active] 198214007633 catalytic site [active] 198214007634 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 198214007635 domain interface [polypeptide binding]; other site 198214007636 putative active site [active] 198214007637 catalytic site [active] 198214007638 lipoprotein; Provisional; Region: PRK10759 198214007639 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 198214007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214007641 putative substrate translocation pore; other site 198214007642 potential protein location (hypothetical protein SF2650 [Shigella flexneri 2a str. 301]) that overlaps RNA (16S ribosomal RNA) 198214007643 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 198214007644 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 198214007645 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 198214007646 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214007647 RNA binding surface [nucleotide binding]; other site 198214007648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198214007649 active site 198214007650 hypothetical protein; Provisional; Region: PRK10723 198214007651 protein disaggregation chaperone; Provisional; Region: PRK10865 198214007652 Clp amino terminal domain; Region: Clp_N; pfam02861 198214007653 Clp amino terminal domain; Region: Clp_N; pfam02861 198214007654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214007655 Walker A motif; other site 198214007656 ATP binding site [chemical binding]; other site 198214007657 Walker B motif; other site 198214007658 arginine finger; other site 198214007659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214007660 Walker A motif; other site 198214007661 ATP binding site [chemical binding]; other site 198214007662 Walker B motif; other site 198214007663 arginine finger; other site 198214007664 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 198214007665 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214007666 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214007667 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214007668 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 198214007669 30S subunit binding site; other site 198214007670 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 198214007671 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 198214007672 Prephenate dehydratase; Region: PDT; pfam00800 198214007673 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 198214007674 putative L-Phe binding site [chemical binding]; other site 198214007675 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 198214007676 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 198214007677 prephenate dehydrogenase; Validated; Region: PRK08507 198214007678 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 198214007679 lipoprotein; Provisional; Region: PRK11443 198214007680 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 198214007681 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1788956 (409 aa). BLAST with identity of 99% in 409 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007682 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 198214007683 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198214007684 ligand binding site [chemical binding]; other site 198214007685 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 198214007686 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 198214007687 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 198214007688 RimM N-terminal domain; Region: RimM; pfam01782 198214007689 PRC-barrel domain; Region: PRC; pfam05239 198214007690 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 198214007691 signal recognition particle protein; Provisional; Region: PRK10867 198214007692 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 198214007693 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198214007694 P loop; other site 198214007695 GTP binding site [chemical binding]; other site 198214007696 Signal peptide binding domain; Region: SRP_SPB; pfam02978 198214007697 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 198214007698 hypothetical protein; Provisional; Region: PRK11573 198214007699 Domain of unknown function DUF21; Region: DUF21; pfam01595 198214007700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198214007701 Transporter associated domain; Region: CorC_HlyC; smart01091 198214007702 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 198214007703 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 198214007704 dimer interface [polypeptide binding]; other site 198214007705 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 198214007706 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 198214007707 recombination and repair protein; Provisional; Region: PRK10869 198214007708 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198214007709 Walker A/P-loop; other site 198214007710 ATP binding site [chemical binding]; other site 198214007711 Q-loop/lid; other site 198214007712 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198214007713 Q-loop/lid; other site 198214007714 ABC transporter signature motif; other site 198214007715 Walker B; other site 198214007716 D-loop; other site 198214007717 H-loop/switch region; other site 198214007718 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 198214007719 hypothetical protein; Validated; Region: PRK01777 198214007720 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 198214007721 putative coenzyme Q binding site [chemical binding]; other site 198214007722 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 198214007723 SmpB-tmRNA interface; other site 198214007724 integrase; Provisional; Region: PRK09692 198214007725 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198214007726 active site 198214007727 Int/Topo IB signature motif; other site 198214007728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214007729 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214007730 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214007731 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214007732 Transposase; Region: HTH_Tnp_1; cl17663 198214007733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214007734 putative transposase OrfB; Reviewed; Region: PHA02517 198214007735 HTH-like domain; Region: HTH_21; pfam13276 198214007736 Integrase core domain; Region: rve; pfam00665 198214007737 Integrase core domain; Region: rve_2; pfam13333 198214007738 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 198214007739 active site 198214007740 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 198214007741 Ca binding site [ion binding]; other site 198214007742 catalytic site [active] 198214007743 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 198214007744 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 198214007745 substrate binding pocket [chemical binding]; other site 198214007746 active site 198214007747 iron coordination sites [ion binding]; other site 198214007748 Predicted dehydrogenase [General function prediction only]; Region: COG0579 198214007749 hydroxyglutarate oxidase; Provisional; Region: PRK11728 198214007750 'Similar to Escherichia coli K12 succinate-semialdehyde dehydrogenase, NADP-dependent activity gi: 1789015 (483 aa). BLAST with identity of 96% in 483 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214007751 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198214007752 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198214007753 inhibitor-cofactor binding pocket; inhibition site 198214007754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214007755 catalytic residue [active] 198214007756 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 198214007757 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 198214007758 DNA-binding site [nucleotide binding]; DNA binding site 198214007759 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214007760 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 198214007761 bacterial OsmY and nodulation domain; Region: BON; smart00749 198214007762 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214007763 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 198214007764 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214007765 HTH-like domain; Region: HTH_21; pfam13276 198214007766 Integrase core domain; Region: rve; pfam00665 198214007767 Integrase core domain; Region: rve_3; pfam13683 198214007768 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214007769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214007770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198214007771 dimerization interface [polypeptide binding]; other site 198214007772 putative DNA binding site [nucleotide binding]; other site 198214007773 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198214007774 putative Zn2+ binding site [ion binding]; other site 198214007775 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 198214007776 active site residue [active] 198214007777 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 198214007778 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 198214007779 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 198214007780 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 198214007781 hypothetical protein; Provisional; Region: PRK10556 198214007782 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 198214007783 catalytic residues [active] 198214007784 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 198214007785 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 198214007786 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 198214007787 Class I ribonucleotide reductase; Region: RNR_I; cd01679 198214007788 active site 198214007789 dimer interface [polypeptide binding]; other site 198214007790 catalytic residues [active] 198214007791 effector binding site; other site 198214007792 R2 peptide binding site; other site 198214007793 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 198214007794 dimer interface [polypeptide binding]; other site 198214007795 putative radical transfer pathway; other site 198214007796 diiron center [ion binding]; other site 198214007797 tyrosyl radical; other site 198214007798 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 198214007799 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 198214007800 Walker A/P-loop; other site 198214007801 ATP binding site [chemical binding]; other site 198214007802 Q-loop/lid; other site 198214007803 ABC transporter signature motif; other site 198214007804 Walker B; other site 198214007805 D-loop; other site 198214007806 H-loop/switch region; other site 198214007807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 198214007808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214007809 dimer interface [polypeptide binding]; other site 198214007810 conserved gate region; other site 198214007811 putative PBP binding loops; other site 198214007812 ABC-ATPase subunit interface; other site 198214007813 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 198214007814 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 198214007815 putative L-valine exporter; Provisional; Region: PRK10408 198214007816 Similar to Escherichia coli K12 multidrug resistance secretion protein gi: 1789041 (391 aa). BLAST with identity of 97% in 391 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007817 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198214007818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214007819 putative substrate translocation pore; other site 198214007820 S-ribosylhomocysteinase; Provisional; Region: PRK02260 198214007821 Predicted membrane protein [Function unknown]; Region: COG1238 198214007822 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 198214007823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214007824 active site 198214007825 motif I; other site 198214007826 motif II; other site 198214007827 potential protein location (hypothetical protein SF2718 [Shigella flexneri 2a str. 301]) that overlaps RNA (tRNA-R) 198214007828 carbon storage regulator; Provisional; Region: PRK01712 198214007829 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 198214007830 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 198214007831 motif 1; other site 198214007832 active site 198214007833 motif 2; other site 198214007834 motif 3; other site 198214007835 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 198214007836 DHHA1 domain; Region: DHHA1; pfam02272 198214007837 recombination regulator RecX; Reviewed; Region: recX; PRK00117 198214007838 recombinase A; Provisional; Region: recA; PRK09354 198214007839 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 198214007840 hexamer interface [polypeptide binding]; other site 198214007841 Walker A motif; other site 198214007842 ATP binding site [chemical binding]; other site 198214007843 Walker B motif; other site 198214007844 hypothetical protein; Validated; Region: PRK03661 198214007845 murein hydrolase B; Provisional; Region: PRK10760 198214007846 lytic murein transglycosylase B; Region: MltB; TIGR02282 198214007847 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214007848 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214007849 'Similar to Escherichia coli K12 PTS system, glucitol/sorbitol-specific IIC component, one of two gi: 1789054 (187 aa). BLAST with identity of 92% in 131 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct.' 198214007850 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 198214007851 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 198214007852 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 198214007853 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 198214007854 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 198214007855 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 198214007856 putative NAD(P) binding site [chemical binding]; other site 198214007857 active site 198214007858 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 198214007859 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 198214007860 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198214007861 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214007862 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 198214007863 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 198214007864 putative active site [active] 198214007865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 198214007866 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 198214007867 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198214007868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214007869 Walker A motif; other site 198214007870 ATP binding site [chemical binding]; other site 198214007871 Walker B motif; other site 198214007872 arginine finger; other site 198214007873 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 198214007874 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198214007875 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 198214007876 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 198214007877 iron binding site [ion binding]; other site 198214007878 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 198214007879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214007880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214007881 Acylphosphatase; Region: Acylphosphatase; pfam00708 198214007882 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 198214007883 HypF finger; Region: zf-HYPF; pfam07503 198214007884 HypF finger; Region: zf-HYPF; pfam07503 198214007885 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 198214007886 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 198214007887 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214007888 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198214007889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214007890 DNA binding site [nucleotide binding] 198214007891 domain linker motif; other site 198214007892 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198214007893 dimerization interface (closed form) [polypeptide binding]; other site 198214007894 ligand binding site [chemical binding]; other site 198214007895 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 198214007896 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 198214007897 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 198214007898 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 198214007899 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 198214007900 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198214007901 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198214007902 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214007903 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214007904 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 198214007905 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 198214007906 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 198214007907 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198214007908 hydrogenase assembly chaperone; Provisional; Region: PRK10409 198214007909 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 198214007910 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 198214007911 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 198214007912 dimerization interface [polypeptide binding]; other site 198214007913 ATP binding site [chemical binding]; other site 198214007914 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 198214007915 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198214007916 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198214007917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214007918 Walker A motif; other site 198214007919 ATP binding site [chemical binding]; other site 198214007920 Walker B motif; other site 198214007921 arginine finger; other site 198214007922 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 198214007923 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 198214007924 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214007925 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 198214007926 MutS domain I; Region: MutS_I; pfam01624 198214007927 MutS domain II; Region: MutS_II; pfam05188 198214007928 MutS domain III; Region: MutS_III; pfam05192 198214007929 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 198214007930 Walker A/P-loop; other site 198214007931 ATP binding site [chemical binding]; other site 198214007932 Q-loop/lid; other site 198214007933 ABC transporter signature motif; other site 198214007934 Walker B; other site 198214007935 D-loop; other site 198214007936 H-loop/switch region; other site 198214007937 Similar to Escherichia coli K12 protein phosphatase 2 gi: 1789090 (219 aa). BLAST with identity of 95% in 218 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007938 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198214007939 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198214007940 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214007941 Similar to Escherichia coli K12 dehydrogenase gi: 1789092 (303 aa). BLAST with identity of 99% in 303 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214007942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214007943 Transposase; Region: HTH_Tnp_1; pfam01527 198214007944 putative transposase OrfB; Reviewed; Region: PHA02517 198214007945 HTH-like domain; Region: HTH_21; pfam13276 198214007946 Integrase core domain; Region: rve; pfam00665 198214007947 Integrase core domain; Region: rve_3; pfam13683 198214007948 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 198214007949 Integrase core domain; Region: rve; pfam00665 198214007950 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 198214007951 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 198214007952 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 198214007953 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 198214007954 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198214007955 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198214007956 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 198214007957 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 198214007958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198214007959 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198214007960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198214007961 DNA binding residues [nucleotide binding] 198214007962 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 198214007963 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214007964 Peptidase family M23; Region: Peptidase_M23; pfam01551 198214007965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214007966 S-adenosylmethionine binding site [chemical binding]; other site 198214007967 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 198214007968 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 198214007969 Permutation of conserved domain; other site 198214007970 active site 198214007971 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 198214007972 homotrimer interaction site [polypeptide binding]; other site 198214007973 zinc binding site [ion binding]; other site 198214007974 CDP-binding sites; other site 198214007975 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 198214007976 substrate binding site; other site 198214007977 dimer interface; other site 198214007978 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 198214007979 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 198214007980 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 198214007981 ligand-binding site [chemical binding]; other site 198214007982 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 198214007983 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 198214007984 CysD dimerization site [polypeptide binding]; other site 198214007985 G1 box; other site 198214007986 putative GEF interaction site [polypeptide binding]; other site 198214007987 GTP/Mg2+ binding site [chemical binding]; other site 198214007988 Switch I region; other site 198214007989 G2 box; other site 198214007990 G3 box; other site 198214007991 Switch II region; other site 198214007992 G4 box; other site 198214007993 G5 box; other site 198214007994 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 198214007995 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 198214007996 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 198214007997 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198214007998 Active Sites [active] 198214007999 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 198214008000 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 198214008001 metal binding site [ion binding]; metal-binding site 198214008002 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 198214008003 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 198214008004 Hok/gef family; Region: HOK_GEF; pfam01848 198214008005 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 198214008006 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198214008007 Active Sites [active] 198214008008 sulfite reductase subunit beta; Provisional; Region: PRK13504 198214008009 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198214008010 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 198214008011 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198214008012 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214008013 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 198214008014 Flavodoxin; Region: Flavodoxin_1; pfam00258 198214008015 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 198214008016 FAD binding pocket [chemical binding]; other site 198214008017 FAD binding motif [chemical binding]; other site 198214008018 catalytic residues [active] 198214008019 NAD binding pocket [chemical binding]; other site 198214008020 phosphate binding motif [ion binding]; other site 198214008021 beta-alpha-beta structure motif; other site 198214008022 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 198214008023 homohexamer interface [polypeptide binding]; other site 198214008024 putative substrate stabilizing pore; other site 198214008025 pterin binding site; other site 198214008026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214008027 putative oxidoreductase FixC; Provisional; Region: PRK10157 198214008028 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 198214008029 Similar to Escherichia coli K12 anti-terminator regulatory protein gi: 1789127 (192 aa). BLAST with identity of 96% in 192 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214008030 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 198214008031 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 198214008032 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 198214008033 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 198214008034 Ligand binding site [chemical binding]; other site 198214008035 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 198214008036 benzoate transport; Region: 2A0115; TIGR00895 198214008037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214008038 putative substrate translocation pore; other site 198214008039 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214008040 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 198214008041 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 198214008042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008043 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008044 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008045 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214008046 enolase; Provisional; Region: eno; PRK00077 198214008047 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 198214008048 dimer interface [polypeptide binding]; other site 198214008049 metal binding site [ion binding]; metal-binding site 198214008050 substrate binding pocket [chemical binding]; other site 198214008051 CTP synthetase; Validated; Region: pyrG; PRK05380 198214008052 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 198214008053 Catalytic site [active] 198214008054 active site 198214008055 UTP binding site [chemical binding]; other site 198214008056 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 198214008057 active site 198214008058 putative oxyanion hole; other site 198214008059 catalytic triad [active] 198214008060 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 198214008061 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 198214008062 homodimer interface [polypeptide binding]; other site 198214008063 metal binding site [ion binding]; metal-binding site 198214008064 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 198214008065 homodimer interface [polypeptide binding]; other site 198214008066 active site 198214008067 putative chemical substrate binding site [chemical binding]; other site 198214008068 metal binding site [ion binding]; metal-binding site 198214008069 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 198214008070 HD domain; Region: HD_4; pfam13328 198214008071 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198214008072 synthetase active site [active] 198214008073 NTP binding site [chemical binding]; other site 198214008074 metal binding site [ion binding]; metal-binding site 198214008075 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 198214008076 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 198214008077 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 198214008078 TRAM domain; Region: TRAM; pfam01938 198214008079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214008080 S-adenosylmethionine binding site [chemical binding]; other site 198214008081 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 198214008082 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 198214008083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214008084 dimerization interface [polypeptide binding]; other site 198214008085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214008086 dimer interface [polypeptide binding]; other site 198214008087 phosphorylation site [posttranslational modification] 198214008088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214008089 ATP binding site [chemical binding]; other site 198214008090 Mg2+ binding site [ion binding]; other site 198214008091 G-X-G motif; other site 198214008092 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 198214008093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214008094 active site 198214008095 phosphorylation site [posttranslational modification] 198214008096 intermolecular recognition site; other site 198214008097 dimerization interface [polypeptide binding]; other site 198214008098 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198214008099 putative binding surface; other site 198214008100 active site 198214008101 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 198214008102 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 198214008103 active site 198214008104 tetramer interface [polypeptide binding]; other site 198214008105 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 198214008106 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 198214008107 active site 198214008108 tetramer interface [polypeptide binding]; other site 198214008109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214008110 D-galactonate transporter; Region: 2A0114; TIGR00893 198214008111 putative substrate translocation pore; other site 198214008112 flavodoxin; Provisional; Region: PRK08105 198214008113 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198214008114 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 198214008115 probable active site [active] 198214008116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 198214008117 SecY interacting protein Syd; Provisional; Region: PRK04968 198214008118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 198214008119 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 198214008120 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 198214008121 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 198214008122 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 198214008123 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 198214008124 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214008125 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214008126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214008127 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198214008128 serine transporter; Region: stp; TIGR00814 198214008129 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 198214008130 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198214008131 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198214008132 flap endonuclease-like protein; Provisional; Region: PRK09482 198214008133 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198214008134 active site 198214008135 metal binding site 1 [ion binding]; metal-binding site 198214008136 putative 5' ssDNA interaction site; other site 198214008137 metal binding site 3; metal-binding site 198214008138 metal binding site 2 [ion binding]; metal-binding site 198214008139 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198214008140 putative DNA binding site [nucleotide binding]; other site 198214008141 putative metal binding site [ion binding]; other site 198214008142 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 198214008143 dimer interface [polypeptide binding]; other site 198214008144 active site 198214008145 metal binding site [ion binding]; metal-binding site 198214008146 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198214008147 intersubunit interface [polypeptide binding]; other site 198214008148 active site 198214008149 Zn2+ binding site [ion binding]; other site 198214008150 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 198214008151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214008152 putative substrate translocation pore; other site 198214008153 L-fucose isomerase; Provisional; Region: fucI; PRK10991 198214008154 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 198214008155 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198214008156 trimer interface [polypeptide binding]; other site 198214008157 substrate binding site [chemical binding]; other site 198214008158 Mn binding site [ion binding]; other site 198214008159 Similar to Escherichia coli K12 L-fuculokinase gi: 1789168 (483 aa). BLAST with identity of 98% in 483 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214008160 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 198214008161 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 198214008162 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198214008163 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214008164 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 198214008165 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 198214008166 hypothetical protein; Provisional; Region: PRK10873 198214008167 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 198214008168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214008169 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 198214008170 dimerization interface [polypeptide binding]; other site 198214008171 substrate binding pocket [chemical binding]; other site 198214008172 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 198214008173 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 198214008174 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 198214008175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198214008176 catalytic residue [active] 198214008177 CsdA-binding activator; Provisional; Region: PRK15019 198214008178 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 198214008179 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 198214008180 putative ATP binding site [chemical binding]; other site 198214008181 putative substrate interface [chemical binding]; other site 198214008182 murein transglycosylase A; Provisional; Region: mltA; PRK11162 198214008183 MltA specific insert domain; Region: MltA; smart00925 198214008184 3D domain; Region: 3D; pfam06725 198214008185 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 198214008186 AMIN domain; Region: AMIN; pfam11741 198214008187 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198214008188 active site 198214008189 metal binding site [ion binding]; metal-binding site 198214008190 N-acetylglutamate synthase; Validated; Region: PRK05279 198214008191 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 198214008192 putative feedback inhibition sensing region; other site 198214008193 putative nucleotide binding site [chemical binding]; other site 198214008194 putative substrate binding site [chemical binding]; other site 198214008195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214008196 Coenzyme A binding pocket [chemical binding]; other site 198214008197 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 198214008198 Helicase; Region: Helicase_RecD; pfam05127 198214008199 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198214008200 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 198214008201 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 198214008202 protease3; Provisional; Region: PRK15101 198214008203 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 198214008204 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198214008205 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198214008206 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 198214008207 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 198214008208 hypothetical protein; Provisional; Region: PRK10332 198214008209 hypothetical protein; Provisional; Region: PRK11521 198214008210 hypothetical protein; Provisional; Region: PRK10557 198214008211 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 198214008212 Similar to Escherichia coli K12 prepilin peptidase dependent protein A gi: 1789190 (157 aa). BLAST with identity of 99% in 156 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214008213 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 198214008214 dimerization interface [polypeptide binding]; other site 198214008215 active site 198214008216 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 198214008217 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 198214008218 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198214008219 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 198214008220 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198214008221 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198214008222 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 198214008223 putative active site [active] 198214008224 Ap4A binding site [chemical binding]; other site 198214008225 nudix motif; other site 198214008226 putative metal binding site [ion binding]; other site 198214008227 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 198214008228 putative DNA-binding cleft [nucleotide binding]; other site 198214008229 putative DNA clevage site; other site 198214008230 molecular lever; other site 198214008231 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198214008232 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 198214008233 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214008234 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 198214008235 active site 198214008236 catalytic tetrad [active] 198214008237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214008238 putative substrate translocation pore; other site 198214008239 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 198214008240 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198214008241 putative acyl-acceptor binding pocket; other site 198214008242 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 198214008243 acyl-activating enzyme (AAE) consensus motif; other site 198214008244 putative AMP binding site [chemical binding]; other site 198214008245 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 198214008246 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214008247 DNA binding site [nucleotide binding] 198214008248 domain linker motif; other site 198214008249 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198214008250 dimerization interface (closed form) [polypeptide binding]; other site 198214008251 ligand binding site [chemical binding]; other site 198214008252 diaminopimelate decarboxylase; Provisional; Region: PRK11165 198214008253 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 198214008254 active site 198214008255 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198214008256 substrate binding site [chemical binding]; other site 198214008257 catalytic residues [active] 198214008258 dimer interface [polypeptide binding]; other site 198214008259 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 198214008260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214008261 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 198214008262 putative dimerization interface [polypeptide binding]; other site 198214008263 putative racemase; Provisional; Region: PRK10200 198214008264 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 198214008265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214008266 putative substrate translocation pore; other site 198214008267 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 198214008268 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 198214008269 NADP binding site [chemical binding]; other site 198214008270 homodimer interface [polypeptide binding]; other site 198214008271 active site 198214008272 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 198214008273 putative acyltransferase; Provisional; Region: PRK05790 198214008274 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198214008275 dimer interface [polypeptide binding]; other site 198214008276 active site 198214008277 Transposase; Region: HTH_Tnp_1; cl17663 198214008278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214008279 putative transposase OrfB; Reviewed; Region: PHA02517 198214008280 HTH-like domain; Region: HTH_21; pfam13276 198214008281 Integrase core domain; Region: rve; pfam00665 198214008282 Integrase core domain; Region: rve_2; pfam13333 198214008283 Protein of unknown function (DUF1682); Region: DUF1682; pfam07946 198214008284 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 198214008285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214008286 Transposase; Region: HTH_Tnp_1; cl17663 198214008287 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 198214008288 Int/Topo IB signature motif; other site 198214008289 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 198214008290 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198214008291 Peptidase family M23; Region: Peptidase_M23; pfam01551 198214008292 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 198214008293 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 198214008294 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 198214008295 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 198214008296 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 198214008297 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 198214008298 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 198214008299 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198214008300 catalytic loop [active] 198214008301 iron binding site [ion binding]; other site 198214008302 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 198214008303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008304 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008305 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008306 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214008307 HTH-like domain; Region: HTH_21; pfam13276 198214008308 Integrase core domain; Region: rve; pfam00665 198214008309 Integrase core domain; Region: rve_3; pfam13683 198214008310 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214008311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214008312 Sulfate transporter family; Region: Sulfate_transp; cl19250 198214008313 xanthine permease; Region: pbuX; TIGR03173 198214008314 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 198214008315 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 198214008316 active site 198214008317 metal binding site [ion binding]; metal-binding site 198214008318 nudix motif; other site 198214008319 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 198214008320 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 198214008321 dimer interface [polypeptide binding]; other site 198214008322 putative anticodon binding site; other site 198214008323 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 198214008324 motif 1; other site 198214008325 active site 198214008326 motif 2; other site 198214008327 motif 3; other site 198214008328 peptide chain release factor 2; Provisional; Region: PRK08787 198214008329 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198214008330 RF-1 domain; Region: RF-1; pfam00472 198214008331 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 198214008332 DHH family; Region: DHH; pfam01368 198214008333 DHHA1 domain; Region: DHHA1; pfam02272 198214008334 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 198214008335 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 198214008336 dimerization domain [polypeptide binding]; other site 198214008337 dimer interface [polypeptide binding]; other site 198214008338 catalytic residues [active] 198214008339 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 198214008340 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 198214008341 active site 198214008342 Int/Topo IB signature motif; other site 198214008343 flavodoxin FldB; Provisional; Region: PRK12359 198214008344 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 198214008345 hypothetical protein; Provisional; Region: PRK10878 198214008346 putative global regulator; Reviewed; Region: PRK09559 198214008347 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 198214008348 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 198214008349 hemolysin; Provisional; Region: PRK15087 198214008350 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789267 (104 aa). BLAST with identity of 98% in 103 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214008351 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 198214008352 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 198214008353 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 198214008354 classical (c) SDRs; Region: SDR_c; cd05233 198214008355 NAD(P) binding site [chemical binding]; other site 198214008356 active site 198214008357 glycine dehydrogenase; Provisional; Region: PRK05367 198214008358 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198214008359 tetramer interface [polypeptide binding]; other site 198214008360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214008361 catalytic residue [active] 198214008362 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198214008363 tetramer interface [polypeptide binding]; other site 198214008364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214008365 catalytic residue [active] 198214008366 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 198214008367 lipoyl attachment site [posttranslational modification]; other site 198214008368 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 198214008369 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 198214008370 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 198214008371 oxidoreductase; Provisional; Region: PRK08013 198214008372 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 198214008373 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 198214008374 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 198214008375 proline aminopeptidase P II; Provisional; Region: PRK10879 198214008376 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 198214008377 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 198214008378 active site 198214008379 hypothetical protein; Reviewed; Region: PRK01736 198214008380 Z-ring-associated protein; Provisional; Region: PRK10972 198214008381 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 198214008382 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 198214008383 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 198214008384 ligand binding site [chemical binding]; other site 198214008385 NAD binding site [chemical binding]; other site 198214008386 tetramer interface [polypeptide binding]; other site 198214008387 catalytic site [active] 198214008388 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 198214008389 L-serine binding site [chemical binding]; other site 198214008390 ACT domain interface; other site 198214008391 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 198214008392 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198214008393 active site 198214008394 dimer interface [polypeptide binding]; other site 198214008395 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789281 (77 aa). BLAST with identity of 97% in 61 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214008396 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 198214008397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214008398 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 198214008399 putative dimerization interface [polypeptide binding]; other site 198214008400 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 198214008401 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 198214008402 active site 198214008403 substrate binding site [chemical binding]; other site 198214008404 coenzyme B12 binding site [chemical binding]; other site 198214008405 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 198214008406 B12 binding site [chemical binding]; other site 198214008407 cobalt ligand [ion binding]; other site 198214008408 LAO/AO transport system ATPase; Region: lao; TIGR00750 198214008409 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 198214008410 Walker A; other site 198214008411 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 198214008412 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198214008413 substrate binding site [chemical binding]; other site 198214008414 oxyanion hole (OAH) forming residues; other site 198214008415 trimer interface [polypeptide binding]; other site 198214008416 Similar to Escherichia coli K12 coenzyme A transferase gi: 1789287 (493 aa). BLAST with identity of 98% in 493 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214008417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214008418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198214008419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198214008420 dimerization interface [polypeptide binding]; other site 198214008421 oxidative stress defense protein; Provisional; Region: PRK11087 198214008422 arginine exporter protein; Provisional; Region: PRK09304 198214008423 mechanosensitive channel MscS; Provisional; Region: PRK10334 198214008424 Conserved TM helix; Region: TM_helix; pfam05552 198214008425 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198214008426 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 198214008427 active site 198214008428 intersubunit interface [polypeptide binding]; other site 198214008429 zinc binding site [ion binding]; other site 198214008430 Na+ binding site [ion binding]; other site 198214008431 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 198214008432 substrate binding site [chemical binding]; other site 198214008433 hinge regions; other site 198214008434 ADP binding site [chemical binding]; other site 198214008435 catalytic site [active] 198214008436 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 198214008437 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198214008438 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198214008439 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 198214008440 trimer interface [polypeptide binding]; other site 198214008441 putative Zn binding site [ion binding]; other site 198214008442 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 198214008443 Similar to Escherichia coli O157:H7 EDL933 conserved hypothetical protein ref: NP_289497.1 (235 aa). BLAST with identity of 97% in 236 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214008444 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198214008445 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198214008446 Walker A/P-loop; other site 198214008447 ATP binding site [chemical binding]; other site 198214008448 Q-loop/lid; other site 198214008449 ABC transporter signature motif; other site 198214008450 Walker B; other site 198214008451 D-loop; other site 198214008452 H-loop/switch region; other site 198214008453 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 198214008454 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 198214008455 Walker A/P-loop; other site 198214008456 ATP binding site [chemical binding]; other site 198214008457 Q-loop/lid; other site 198214008458 ABC transporter signature motif; other site 198214008459 Walker B; other site 198214008460 D-loop; other site 198214008461 H-loop/switch region; other site 198214008462 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 198214008463 active site 198214008464 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 198214008465 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 198214008466 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198214008467 putative NAD(P) binding site [chemical binding]; other site 198214008468 catalytic Zn binding site [ion binding]; other site 198214008469 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214008470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008471 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008472 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008473 prohibitin homologues; Region: PHB; smart00244 198214008474 Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401 198214008475 transketolase; Reviewed; Region: PRK12753 198214008476 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198214008477 TPP-binding site [chemical binding]; other site 198214008478 dimer interface [polypeptide binding]; other site 198214008479 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198214008480 PYR/PP interface [polypeptide binding]; other site 198214008481 dimer interface [polypeptide binding]; other site 198214008482 TPP binding site [chemical binding]; other site 198214008483 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198214008484 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 198214008485 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 198214008486 oligomer interface [polypeptide binding]; other site 198214008487 putative active site [active] 198214008488 Mn binding site [ion binding]; other site 198214008489 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214008490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008491 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008492 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008493 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 198214008494 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 198214008495 dimer interface [polypeptide binding]; other site 198214008496 active site 198214008497 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198214008498 catalytic residues [active] 198214008499 substrate binding site [chemical binding]; other site 198214008500 Virulence promoting factor; Region: YqgB; pfam11036 198214008501 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 198214008502 S-adenosylmethionine synthetase; Validated; Region: PRK05250 198214008503 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 198214008504 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 198214008505 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 198214008506 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 198214008507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214008508 putative substrate translocation pore; other site 198214008509 hypothetical protein; Provisional; Region: PRK04860 198214008510 DNA-specific endonuclease I; Provisional; Region: PRK15137 198214008511 RNA methyltransferase, RsmE family; Region: TIGR00046 198214008512 glutathione synthetase; Provisional; Region: PRK05246 198214008513 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 198214008514 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 198214008515 hypothetical protein; Validated; Region: PRK00228 198214008516 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 198214008517 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 198214008518 Walker A motif; other site 198214008519 ATP binding site [chemical binding]; other site 198214008520 Walker B motif; other site 198214008521 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 198214008522 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198214008523 catalytic residue [active] 198214008524 YGGT family; Region: YGGT; pfam02325 198214008525 Predicted integral membrane protein [Function unknown]; Region: COG0762 198214008526 hypothetical protein; Validated; Region: PRK05090 198214008527 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 198214008528 active site 198214008529 dimerization interface [polypeptide binding]; other site 198214008530 HemN family oxidoreductase; Provisional; Region: PRK05660 198214008531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214008532 FeS/SAM binding site; other site 198214008533 HemN C-terminal domain; Region: HemN_C; pfam06969 198214008534 SI#48 198214008535 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 198214008536 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214008537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008538 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008539 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008540 DctM-like transporters; Region: DctM; pfam06808 198214008541 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 198214008542 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 198214008543 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 198214008544 active site 198214008545 homodimer interface [polypeptide binding]; other site 198214008546 hypothetical protein; Provisional; Region: PRK10626 198214008547 hypothetical protein; Provisional; Region: PRK11702 198214008548 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 198214008549 adenine DNA glycosylase; Provisional; Region: PRK10880 198214008550 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198214008551 minor groove reading motif; other site 198214008552 helix-hairpin-helix signature motif; other site 198214008553 substrate binding pocket [chemical binding]; other site 198214008554 active site 198214008555 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 198214008556 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 198214008557 DNA binding and oxoG recognition site [nucleotide binding] 198214008558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 198214008559 murein transglycosylase C; Provisional; Region: mltC; PRK11671 198214008560 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 198214008561 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214008562 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214008563 catalytic residue [active] 198214008564 nucleoside transporter; Region: 2A0110; TIGR00889 198214008565 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 198214008566 ornithine decarboxylase; Provisional; Region: PRK13578 198214008567 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 198214008568 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198214008569 homodimer interface [polypeptide binding]; other site 198214008570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214008571 catalytic residue [active] 198214008572 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198214008573 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 198214008574 integrase; Provisional; Region: PRK09692 198214008575 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198214008576 active site 198214008577 Int/Topo IB signature motif; other site 198214008578 replicative DNA helicase; Provisional; Region: PRK05973 198214008579 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 198214008580 AAA domain; Region: AAA_12; pfam13087 198214008581 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 198214008582 putative active site [active] 198214008583 catalytic site [active] 198214008584 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 198214008585 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198214008586 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 198214008587 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198214008588 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214008589 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198214008590 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214008591 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214008592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 198214008593 Transposase; Region: DDE_Tnp_ISL3; pfam01610 198214008594 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214008595 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214008596 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198214008597 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 198214008598 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198214008599 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214008600 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198214008601 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 198214008602 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 198214008603 putative active site [active] 198214008604 putative NTP binding site [chemical binding]; other site 198214008605 putative nucleic acid binding site [nucleotide binding]; other site 198214008606 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 198214008607 Transposase; Region: HTH_Tnp_1; cl17663 198214008608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214008609 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 198214008610 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 198214008611 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 198214008612 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214008613 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214008614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214008615 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 198214008616 HTH-like domain; Region: HTH_21; pfam13276 198214008617 Integrase core domain; Region: rve; pfam00665 198214008618 Integrase core domain; Region: rve_3; pfam13683 198214008619 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 198214008620 Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673 198214008621 Predicted GTPase [General function prediction only]; Region: COG3596 198214008622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214008623 YfjP GTPase; Region: YfjP; cd11383 198214008624 G1 box; other site 198214008625 GTP/Mg2+ binding site [chemical binding]; other site 198214008626 Switch I region; other site 198214008627 G2 box; other site 198214008628 Switch II region; other site 198214008629 G3 box; other site 198214008630 G4 box; other site 198214008631 G5 box; other site 198214008632 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198214008633 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 198214008634 hypothetical protein; Provisional; Region: PRK09945 198214008635 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 198214008636 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214008637 Autotransporter beta-domain; Region: Autotransporter; smart00869 198214008638 Domain of unknown function (DUF932); Region: DUF932; pfam06067 198214008639 Antirestriction protein; Region: Antirestrict; pfam03230 198214008640 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 198214008641 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 198214008642 MPN+ (JAMM) motif; other site 198214008643 Zinc-binding site [ion binding]; other site 198214008644 Protein of unknown function (DUF987); Region: DUF987; pfam06174 198214008645 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 198214008646 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 198214008647 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 198214008648 Methyltransferase domain; Region: Methyltransf_27; pfam13708 198214008649 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214008650 Transposase; Region: HTH_Tnp_1; cl17663 198214008651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214008652 putative transposase OrfB; Reviewed; Region: PHA02517 198214008653 HTH-like domain; Region: HTH_21; pfam13276 198214008654 Integrase core domain; Region: rve; pfam00665 198214008655 Integrase core domain; Region: rve_2; pfam13333 198214008656 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 198214008657 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 198214008658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 198214008659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198214008660 DNA binding site [nucleotide binding] 198214008661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008662 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008663 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008665 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008666 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008667 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 198214008668 active site 198214008669 hypothetical protein; Provisional; Region: PRK09732 198214008670 Similar to Escherichia coli K12 glycolate oxidase iron-sulfur subunit gi: 1789350 (762 aa). BLAST with identity of 98% in 760 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214008671 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 198214008672 FAD binding domain; Region: FAD_binding_4; pfam01565 198214008673 Similar to Escherichia coli K12 glycolate oxidase subunit D gi: 1789351 (500 aa). BLAST with identity of 98% in 497 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214008674 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 198214008675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214008676 DNA-binding site [nucleotide binding]; DNA binding site 198214008677 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214008678 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789354 (391 aa). BLAST with identity of 99% in 367 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214008679 acyl-CoA synthetase; Validated; Region: PRK09192 198214008680 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 198214008681 acyl-activating enzyme (AAE) consensus motif; other site 198214008682 active site 198214008683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198214008684 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198214008685 NAD(P) binding site [chemical binding]; other site 198214008686 active site 198214008687 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198214008688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 198214008689 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198214008690 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198214008691 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 198214008692 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198214008693 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 198214008694 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 198214008695 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 198214008696 active site 198214008697 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198214008698 thymidylate kinase; Region: DTMP_kinase; TIGR00041 198214008699 TMP-binding site; other site 198214008700 ATP-binding site [chemical binding]; other site 198214008701 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 198214008702 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198214008703 TMP-binding site; other site 198214008704 ATP-binding site [chemical binding]; other site 198214008705 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198214008706 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 198214008707 CHAP domain; Region: CHAP; pfam05257 198214008708 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 198214008709 putative S-transferase; Provisional; Region: PRK11752 198214008710 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 198214008711 C-terminal domain interface [polypeptide binding]; other site 198214008712 GSH binding site (G-site) [chemical binding]; other site 198214008713 dimer interface [polypeptide binding]; other site 198214008714 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 198214008715 dimer interface [polypeptide binding]; other site 198214008716 N-terminal domain interface [polypeptide binding]; other site 198214008717 active site 198214008718 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 198214008719 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 198214008720 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 198214008721 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 198214008722 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 198214008723 putative substrate-binding site; other site 198214008724 nickel binding site [ion binding]; other site 198214008725 hydrogenase 2 large subunit; Provisional; Region: PRK10467 198214008726 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 198214008727 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 198214008728 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214008729 hydrogenase 2 small subunit; Provisional; Region: PRK10468 198214008730 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 198214008731 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 198214008732 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 198214008733 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 198214008734 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 198214008735 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 198214008736 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214008737 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 198214008738 active site 198214008739 catalytic tetrad [active] 198214008740 hypothetical protein; Provisional; Region: PRK05208 198214008741 oxidoreductase; Provisional; Region: PRK07985 198214008742 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 198214008743 NAD binding site [chemical binding]; other site 198214008744 metal binding site [ion binding]; metal-binding site 198214008745 active site 198214008746 biopolymer transport protein ExbD; Provisional; Region: PRK11267 198214008747 biopolymer transport protein ExbB; Provisional; Region: PRK10414 198214008748 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198214008749 homodimer interface [polypeptide binding]; other site 198214008750 substrate-cofactor binding pocket; other site 198214008751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214008752 catalytic residue [active] 198214008753 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198214008754 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 198214008755 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198214008756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214008757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214008758 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 198214008759 dimer interface [polypeptide binding]; other site 198214008760 active site 198214008761 metal binding site [ion binding]; metal-binding site 198214008762 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198214008763 active site 198214008764 catalytic tetrad [active] 198214008765 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 198214008766 putative outer membrane lipoprotein; Provisional; Region: PRK09973 198214008767 hypothetical protein; Provisional; Region: PRK01254 198214008768 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 198214008769 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 198214008770 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 198214008771 FtsI repressor; Provisional; Region: PRK10883 198214008772 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 198214008773 Domain 2 interface [polypeptide binding]; other site 198214008774 Domain 3 interface [polypeptide binding]; other site 198214008775 trinuclear Cu binding site [ion binding]; other site 198214008776 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 198214008777 Domain 1 interface [polypeptide binding]; other site 198214008778 Domain 3 interface [polypeptide binding]; other site 198214008779 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 198214008780 Domain 2 interface [polypeptide binding]; other site 198214008781 Domain 1 interface [polypeptide binding]; other site 198214008782 Type 1 (T1) Cu binding site [ion binding]; other site 198214008783 trinuclear Cu binding site [ion binding]; other site 198214008784 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198214008785 putative acyl-acceptor binding pocket; other site 198214008786 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 198214008787 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198214008788 CAP-like domain; other site 198214008789 active site 198214008790 primary dimer interface [polypeptide binding]; other site 198214008791 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198214008792 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 198214008793 TIGR00156 family protein; Region: TIGR00156 198214008794 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 198214008795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214008796 active site 198214008797 phosphorylation site [posttranslational modification] 198214008798 intermolecular recognition site; other site 198214008799 dimerization interface [polypeptide binding]; other site 198214008800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214008801 DNA binding site [nucleotide binding] 198214008802 sensor protein QseC; Provisional; Region: PRK10337 198214008803 HAMP domain; Region: HAMP; pfam00672 198214008804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214008805 dimer interface [polypeptide binding]; other site 198214008806 phosphorylation site [posttranslational modification] 198214008807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214008808 ATP binding site [chemical binding]; other site 198214008809 G-X-G motif; other site 198214008810 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 198214008811 Uncharacterized conserved protein [Function unknown]; Region: COG1359 198214008812 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 198214008813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214008814 ATP binding site [chemical binding]; other site 198214008815 Mg2+ binding site [ion binding]; other site 198214008816 G-X-G motif; other site 198214008817 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198214008818 anchoring element; other site 198214008819 dimer interface [polypeptide binding]; other site 198214008820 ATP binding site [chemical binding]; other site 198214008821 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 198214008822 active site 198214008823 metal binding site [ion binding]; metal-binding site 198214008824 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198214008825 esterase YqiA; Provisional; Region: PRK11071 198214008826 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 198214008827 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 198214008828 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 198214008829 active site 198214008830 metal binding site [ion binding]; metal-binding site 198214008831 hexamer interface [polypeptide binding]; other site 198214008832 putative dehydrogenase; Provisional; Region: PRK11039 198214008833 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 198214008834 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198214008835 dimer interface [polypeptide binding]; other site 198214008836 ADP-ribose binding site [chemical binding]; other site 198214008837 active site 198214008838 nudix motif; other site 198214008839 metal binding site [ion binding]; metal-binding site 198214008840 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 198214008841 Outer membrane efflux protein; Region: OEP; pfam02321 198214008842 Outer membrane efflux protein; Region: OEP; pfam02321 198214008843 hypothetical protein; Provisional; Region: PRK11653 198214008844 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 198214008845 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 198214008846 putative active site [active] 198214008847 metal binding site [ion binding]; metal-binding site 198214008848 zinc transporter ZupT; Provisional; Region: PRK04201 198214008849 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 198214008850 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 198214008851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 198214008852 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214008853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214008854 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214008855 HTH-like domain; Region: HTH_21; pfam13276 198214008856 Integrase core domain; Region: rve; pfam00665 198214008857 Integrase core domain; Region: rve_3; pfam13683 198214008858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008859 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008860 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214008861 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214008862 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789427 (355 aa). BLAST with identity of 95% in 108 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214008863 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 198214008864 Similar to Escherichia coli K12 membrane protein gi: 1789430 (554 aa). BLAST with identity of 96% in 303 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214008865 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 198214008866 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 198214008867 putative ribose interaction site [chemical binding]; other site 198214008868 putative ADP binding site [chemical binding]; other site 198214008869 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 198214008870 active site 198214008871 nucleotide binding site [chemical binding]; other site 198214008872 HIGH motif; other site 198214008873 KMSKS motif; other site 198214008874 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 198214008875 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198214008876 metal binding triad; other site 198214008877 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198214008878 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198214008879 metal binding triad; other site 198214008880 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 198214008881 Uncharacterized conserved protein [Function unknown]; Region: COG3025 198214008882 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 198214008883 putative active site [active] 198214008884 putative metal binding residues [ion binding]; other site 198214008885 signature motif; other site 198214008886 putative triphosphate binding site [ion binding]; other site 198214008887 CHAD domain; Region: CHAD; pfam05235 198214008888 SH3 domain-containing protein; Provisional; Region: PRK10884 198214008889 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 198214008890 Bacterial SH3 domain homologues; Region: SH3b; smart00287 198214008891 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 198214008892 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 198214008893 active site 198214008894 NTP binding site [chemical binding]; other site 198214008895 metal binding triad [ion binding]; metal-binding site 198214008896 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 198214008897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198214008898 Zn2+ binding site [ion binding]; other site 198214008899 Mg2+ binding site [ion binding]; other site 198214008900 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 198214008901 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 198214008902 homooctamer interface [polypeptide binding]; other site 198214008903 active site 198214008904 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 198214008905 transcriptional activator TtdR; Provisional; Region: PRK09801 198214008906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214008907 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 198214008908 putative effector binding pocket; other site 198214008909 putative dimerization interface [polypeptide binding]; other site 198214008910 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 198214008911 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 198214008912 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 198214008913 anion transporter; Region: dass; TIGR00785 198214008914 transmembrane helices; other site 198214008915 UGMP family protein; Validated; Region: PRK09604 198214008916 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214008917 nucleotide binding site [chemical binding]; other site 198214008918 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 198214008919 DNA primase; Validated; Region: dnaG; PRK05667 198214008920 CHC2 zinc finger; Region: zf-CHC2; pfam01807 198214008921 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 198214008922 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 198214008923 active site 198214008924 metal binding site [ion binding]; metal-binding site 198214008925 interdomain interaction site; other site 198214008926 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 198214008927 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 198214008928 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 198214008929 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 198214008930 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 198214008931 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 198214008932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198214008933 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198214008934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198214008935 DNA binding residues [nucleotide binding] 198214008936 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214008937 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214008938 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214008939 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789449 (169 aa). BLAST with identity of 99% in 168 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214008940 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789450 (255 aa). BLAST with identity of 99% in 248 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214008941 Predicted transcriptional regulators [Transcription]; Region: COG1695 198214008942 'Similar to Escherichia coli K12 aerotaxis sensor receptor, flavoprotein gi: 1789453 (507 aa). BLAST with identity of 98% in 506 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214008943 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198214008944 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198214008945 inhibitor-cofactor binding pocket; inhibition site 198214008946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214008947 catalytic residue [active] 198214008948 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 198214008949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214008950 DNA binding site [nucleotide binding] 198214008951 domain linker motif; other site 198214008952 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 198214008953 putative dimerization interface [polypeptide binding]; other site 198214008954 putative ligand binding site [chemical binding]; other site 198214008955 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 198214008956 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 198214008957 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 198214008958 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 198214008959 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 198214008960 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 198214008961 inner membrane transporter YjeM; Provisional; Region: PRK15238 198214008962 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789461 (357 aa). BLAST with identity of 97% in 357 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214008963 alpha-glucosidase; Provisional; Region: PRK10137 198214008964 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 198214008965 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 198214008966 active site 198214008967 FMN binding site [chemical binding]; other site 198214008968 2,4-decadienoyl-CoA binding site; other site 198214008969 catalytic residue [active] 198214008970 4Fe-4S cluster binding site [ion binding]; other site 198214008971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214008972 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 198214008973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214008974 non-specific DNA binding site [nucleotide binding]; other site 198214008975 salt bridge; other site 198214008976 sequence-specific DNA binding site [nucleotide binding]; other site 198214008977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 198214008978 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 198214008979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214008980 S-adenosylmethionine binding site [chemical binding]; other site 198214008981 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 198214008982 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198214008983 putative active site [active] 198214008984 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198214008985 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198214008986 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 198214008987 serine/threonine transporter SstT; Provisional; Region: PRK13628 198214008988 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 198214008989 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 198214008990 galactarate dehydratase; Region: galactar-dH20; TIGR03248 198214008991 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 198214008992 glucuronate isomerase; Reviewed; Region: PRK02925 198214008993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214008994 D-galactonate transporter; Region: 2A0114; TIGR00893 198214008995 putative substrate translocation pore; other site 198214008996 CblD like pilus biogenesis initiator; Region: CblD; cl06460 198214008997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214008998 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214008999 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214009000 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214009001 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 198214009002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214009003 DNA-binding site [nucleotide binding]; DNA binding site 198214009004 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214009005 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198214009006 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 198214009007 Similar to Escherichia coli K12 conserved hypothetical protein gi: 2367195 (128 aa). BLAST with identity of 99% in 123 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214009008 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 198214009009 Predicted membrane protein [Function unknown]; Region: COG5393 198214009010 YqjK-like protein; Region: YqjK; pfam13997 198214009011 Predicted membrane protein [Function unknown]; Region: COG2259 198214009012 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 198214009013 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 198214009014 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 198214009015 putative dimer interface [polypeptide binding]; other site 198214009016 N-terminal domain interface [polypeptide binding]; other site 198214009017 putative substrate binding pocket (H-site) [chemical binding]; other site 198214009018 Predicted membrane protein [Function unknown]; Region: COG3152 198214009019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214009020 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 198214009021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214009022 dimerization interface [polypeptide binding]; other site 198214009023 Pirin-related protein [General function prediction only]; Region: COG1741 198214009024 Pirin; Region: Pirin; pfam02678 198214009025 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 198214009026 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198214009027 serine transporter; Region: stp; TIGR00814 198214009028 L-serine dehydratase TdcG; Provisional; Region: PRK15040 198214009029 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198214009030 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198214009031 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198214009032 homotrimer interaction site [polypeptide binding]; other site 198214009033 putative active site [active] 198214009034 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 198214009035 Pyruvate formate lyase 1; Region: PFL1; cd01678 198214009036 coenzyme A binding site [chemical binding]; other site 198214009037 active site 198214009038 catalytic residues [active] 198214009039 glycine loop; other site 198214009040 propionate/acetate kinase; Provisional; Region: PRK12379 198214009041 threonine/serine transporter TdcC; Provisional; Region: PRK13629 198214009042 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198214009043 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198214009044 tetramer interface [polypeptide binding]; other site 198214009045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214009046 catalytic residue [active] 198214009047 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 198214009048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214009049 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 198214009050 putative substrate binding pocket [chemical binding]; other site 198214009051 putative dimerization interface [polypeptide binding]; other site 198214009052 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 198214009053 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789509 (396 aa). BLAST with identity of 96% in 393 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214009054 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 198214009055 glycerate kinase I; Provisional; Region: PRK10342 198214009056 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 198214009057 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 198214009058 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 198214009059 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789514 (257 aa). BLAST with identity of 99% in 256 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214009060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214009061 D-galactonate transporter; Region: 2A0114; TIGR00893 198214009062 putative substrate translocation pore; other site 198214009063 galactarate dehydratase; Region: galactar-dH20; TIGR03248 198214009064 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 198214009065 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 198214009066 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 198214009067 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198214009068 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214009069 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 198214009070 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 198214009071 active site 198214009072 phosphorylation site [posttranslational modification] 198214009073 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 198214009074 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 198214009075 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198214009076 active pocket/dimerization site; other site 198214009077 active site 198214009078 phosphorylation site [posttranslational modification] 198214009079 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 198214009080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198214009081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214009082 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214009083 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214009084 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214009085 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 198214009086 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 198214009087 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198214009088 active site 198214009089 trimer interface [polypeptide binding]; other site 198214009090 allosteric site; other site 198214009091 active site lid [active] 198214009092 Similar to Escherichia coli K12 fimbrial-like protein gi: 1789531 (195 aa). BLAST with identity of 96% in 454 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214009093 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214009094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214009095 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214009096 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214009097 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 198214009098 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 198214009099 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 198214009100 Similar to Escherichia coli K12 outer membrane protein gi: 1789533 (839 aa). BLAST with identity of 98% in 1284 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214009101 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214009102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214009103 Fimbrial protein; Region: Fimbrial; cl01416 198214009104 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 198214009105 putative SAM binding site [chemical binding]; other site 198214009106 putative homodimer interface [polypeptide binding]; other site 198214009107 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 198214009108 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 198214009109 putative ligand binding site [chemical binding]; other site 198214009110 TIGR00252 family protein; Region: TIGR00252 198214009111 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 198214009112 dimer interface [polypeptide binding]; other site 198214009113 active site 198214009114 outer membrane lipoprotein; Provisional; Region: PRK11023 198214009115 BON domain; Region: BON; pfam04972 198214009116 BON domain; Region: BON; pfam04972 198214009117 Predicted permease; Region: DUF318; pfam03773 198214009118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198214009119 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 198214009120 NAD(P) binding site [chemical binding]; other site 198214009121 active site 198214009122 intracellular protease, PfpI family; Region: PfpI; TIGR01382 198214009123 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 198214009124 proposed catalytic triad [active] 198214009125 conserved cys residue [active] 198214009126 hypothetical protein; Provisional; Region: PRK03467 198214009127 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 198214009128 GIY-YIG motif/motif A; other site 198214009129 putative active site [active] 198214009130 putative metal binding site [ion binding]; other site 198214009131 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198214009132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214009133 Coenzyme A binding pocket [chemical binding]; other site 198214009134 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 198214009135 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198214009136 putative protease; Provisional; Region: PRK15447 198214009137 hypothetical protein; Provisional; Region: PRK10508 198214009138 tryptophan permease; Provisional; Region: PRK10483 198214009139 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198214009140 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 198214009141 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198214009142 ATP binding site [chemical binding]; other site 198214009143 Mg++ binding site [ion binding]; other site 198214009144 motif III; other site 198214009145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214009146 nucleotide binding region [chemical binding]; other site 198214009147 ATP-binding site [chemical binding]; other site 198214009148 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 198214009149 putative RNA binding site [nucleotide binding]; other site 198214009150 lipoprotein NlpI; Provisional; Region: PRK11189 198214009151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198214009152 binding surface 198214009153 TPR motif; other site 198214009154 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 198214009155 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 198214009156 RNase E interface [polypeptide binding]; other site 198214009157 trimer interface [polypeptide binding]; other site 198214009158 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 198214009159 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 198214009160 RNase E interface [polypeptide binding]; other site 198214009161 trimer interface [polypeptide binding]; other site 198214009162 active site 198214009163 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 198214009164 putative nucleic acid binding region [nucleotide binding]; other site 198214009165 G-X-X-G motif; other site 198214009166 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 198214009167 RNA binding site [nucleotide binding]; other site 198214009168 domain interface; other site 198214009169 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 198214009170 16S/18S rRNA binding site [nucleotide binding]; other site 198214009171 S13e-L30e interaction site [polypeptide binding]; other site 198214009172 25S rRNA binding site [nucleotide binding]; other site 198214009173 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 198214009174 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 198214009175 RNA binding site [nucleotide binding]; other site 198214009176 active site 198214009177 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 198214009178 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 198214009179 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198214009180 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 198214009181 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 198214009182 translation initiation factor IF-2; Validated; Region: infB; PRK05306 198214009183 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198214009184 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 198214009185 G1 box; other site 198214009186 putative GEF interaction site [polypeptide binding]; other site 198214009187 GTP/Mg2+ binding site [chemical binding]; other site 198214009188 Switch I region; other site 198214009189 G2 box; other site 198214009190 G3 box; other site 198214009191 Switch II region; other site 198214009192 G4 box; other site 198214009193 G5 box; other site 198214009194 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 198214009195 Translation-initiation factor 2; Region: IF-2; pfam11987 198214009196 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 198214009197 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 198214009198 NusA N-terminal domain; Region: NusA_N; pfam08529 198214009199 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 198214009200 RNA binding site [nucleotide binding]; other site 198214009201 homodimer interface [polypeptide binding]; other site 198214009202 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 198214009203 G-X-X-G motif; other site 198214009204 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 198214009205 G-X-X-G motif; other site 198214009206 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 198214009207 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 198214009208 hypothetical protein; Provisional; Region: PRK14641 198214009209 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 198214009210 putative oligomer interface [polypeptide binding]; other site 198214009211 putative RNA binding site [nucleotide binding]; other site 198214009212 potential protein location (hypothetical protein SF3212 [Shigella flexneri 2a str. 301]) that overlaps RNA (tRNA-M) 198214009213 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 198214009214 ANP binding site [chemical binding]; other site 198214009215 Substrate Binding Site II [chemical binding]; other site 198214009216 Substrate Binding Site I [chemical binding]; other site 198214009217 Similar to Escherichia coli K12 alkaline phosphatase I gi: 1789564 (548 aa). BLAST with identity of 99% in 548 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214009218 Preprotein translocase SecG subunit; Region: SecG; pfam03840 198214009219 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 198214009220 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 198214009221 active site 198214009222 substrate binding site [chemical binding]; other site 198214009223 metal binding site [ion binding]; metal-binding site 198214009224 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 198214009225 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 198214009226 substrate binding pocket [chemical binding]; other site 198214009227 dimer interface [polypeptide binding]; other site 198214009228 inhibitor binding site; inhibition site 198214009229 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 198214009230 FtsH Extracellular; Region: FtsH_ext; pfam06480 198214009231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214009232 Walker A motif; other site 198214009233 ATP binding site [chemical binding]; other site 198214009234 Walker B motif; other site 198214009235 arginine finger; other site 198214009236 Peptidase family M41; Region: Peptidase_M41; pfam01434 198214009237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214009238 S-adenosylmethionine binding site [chemical binding]; other site 198214009239 RNA-binding protein YhbY; Provisional; Region: PRK10343 198214009240 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 198214009241 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 198214009242 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198214009243 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 198214009244 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 198214009245 GTPase CgtA; Reviewed; Region: obgE; PRK12298 198214009246 GTP1/OBG; Region: GTP1_OBG; pfam01018 198214009247 Obg GTPase; Region: Obg; cd01898 198214009248 G1 box; other site 198214009249 GTP/Mg2+ binding site [chemical binding]; other site 198214009250 Switch I region; other site 198214009251 G2 box; other site 198214009252 G3 box; other site 198214009253 Switch II region; other site 198214009254 G4 box; other site 198214009255 G5 box; other site 198214009256 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198214009257 EamA-like transporter family; Region: EamA; pfam00892 198214009258 EamA-like transporter family; Region: EamA; pfam00892 198214009259 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 198214009260 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 198214009261 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198214009262 substrate binding pocket [chemical binding]; other site 198214009263 chain length determination region; other site 198214009264 substrate-Mg2+ binding site; other site 198214009265 catalytic residues [active] 198214009266 aspartate-rich region 1; other site 198214009267 active site lid residues [active] 198214009268 aspartate-rich region 2; other site 198214009269 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 198214009270 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 198214009271 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 198214009272 hinge; other site 198214009273 active site 198214009274 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 198214009275 Predicted NTP binding protein (contains STAS domain) [General function prediction only]; Region: COG3113 198214009276 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 198214009277 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 198214009278 mce related protein; Region: MCE; pfam02470 198214009279 conserved hypothetical integral membrane protein; Region: TIGR00056 198214009280 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 198214009281 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 198214009282 Walker A/P-loop; other site 198214009283 ATP binding site [chemical binding]; other site 198214009284 Q-loop/lid; other site 198214009285 ABC transporter signature motif; other site 198214009286 Walker B; other site 198214009287 D-loop; other site 198214009288 H-loop/switch region; other site 198214009289 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 198214009290 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198214009291 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198214009292 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 198214009293 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 198214009294 putative active site [active] 198214009295 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 198214009296 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 198214009297 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 198214009298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 198214009299 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 198214009300 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 198214009301 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 198214009302 Walker A/P-loop; other site 198214009303 ATP binding site [chemical binding]; other site 198214009304 Q-loop/lid; other site 198214009305 ABC transporter signature motif; other site 198214009306 Walker B; other site 198214009307 D-loop; other site 198214009308 H-loop/switch region; other site 198214009309 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 198214009310 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 198214009311 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 198214009312 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 198214009313 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 198214009314 30S subunit binding site; other site 198214009315 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214009316 active site 198214009317 phosphorylation site [posttranslational modification] 198214009318 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 198214009319 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198214009320 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198214009321 dimerization domain swap beta strand [polypeptide binding]; other site 198214009322 regulatory protein interface [polypeptide binding]; other site 198214009323 active site 198214009324 regulatory phosphorylation site [posttranslational modification]; other site 198214009325 hypothetical protein; Provisional; Region: PRK10345 198214009326 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 198214009327 Similar to Escherichia coli K12 peptidoglycan enzyme gi: 1789601 (243 aa). BLAST with identity of 99% in 242 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214009328 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 198214009329 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 198214009330 conserved cys residue [active] 198214009331 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 198214009332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198214009333 putative active site [active] 198214009334 heme pocket [chemical binding]; other site 198214009335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214009336 dimer interface [polypeptide binding]; other site 198214009337 phosphorylation site [posttranslational modification] 198214009338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214009339 ATP binding site [chemical binding]; other site 198214009340 Mg2+ binding site [ion binding]; other site 198214009341 G-X-G motif; other site 198214009342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214009343 active site 198214009344 phosphorylation site [posttranslational modification] 198214009345 intermolecular recognition site; other site 198214009346 dimerization interface [polypeptide binding]; other site 198214009347 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198214009348 putative binding surface; other site 198214009349 active site 198214009350 radical SAM protein, TIGR01212 family; Region: TIGR01212 198214009351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214009352 FeS/SAM binding site; other site 198214009353 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 198214009354 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 198214009355 active site 198214009356 dimer interface [polypeptide binding]; other site 198214009357 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 198214009358 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 198214009359 active site 198214009360 FMN binding site [chemical binding]; other site 198214009361 substrate binding site [chemical binding]; other site 198214009362 3Fe-4S cluster binding site [ion binding]; other site 198214009363 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 198214009364 domain interface; other site 198214009365 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 198214009366 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 198214009367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214009368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214009369 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789614 (376 aa). BLAST with identity of 92% in 135 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214009370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214009371 Transposase; Region: HTH_Tnp_1; pfam01527 198214009372 putative transposase OrfB; Reviewed; Region: PHA02517 198214009373 HTH-like domain; Region: HTH_21; pfam13276 198214009374 Integrase core domain; Region: rve; pfam00665 198214009375 Integrase core domain; Region: rve_3; pfam13683 198214009376 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 198214009377 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198214009378 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198214009379 nucleotide binding site [chemical binding]; other site 198214009380 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 198214009381 putative active site cavity [active] 198214009382 putative sialic acid transporter; Provisional; Region: PRK03893 198214009383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214009384 putative substrate translocation pore; other site 198214009385 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 198214009386 inhibitor site; inhibition site 198214009387 active site 198214009388 dimer interface [polypeptide binding]; other site 198214009389 catalytic residue [active] 198214009390 transcriptional regulator NanR; Provisional; Region: PRK03837 198214009391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214009392 DNA-binding site [nucleotide binding]; DNA binding site 198214009393 FCD domain; Region: FCD; pfam07729 198214009394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214009395 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214009396 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214009397 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214009398 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214009399 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 198214009400 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 198214009401 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 198214009402 stringent starvation protein A; Provisional; Region: sspA; PRK09481 198214009403 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 198214009404 C-terminal domain interface [polypeptide binding]; other site 198214009405 putative GSH binding site (G-site) [chemical binding]; other site 198214009406 dimer interface [polypeptide binding]; other site 198214009407 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 198214009408 dimer interface [polypeptide binding]; other site 198214009409 N-terminal domain interface [polypeptide binding]; other site 198214009410 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 198214009411 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 198214009412 23S rRNA interface [nucleotide binding]; other site 198214009413 L3 interface [polypeptide binding]; other site 198214009414 Predicted ATPase [General function prediction only]; Region: COG1485 198214009415 hypothetical protein; Provisional; Region: PRK11677 198214009416 serine endoprotease; Provisional; Region: PRK10898 198214009417 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198214009418 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198214009419 protein binding site [polypeptide binding]; other site 198214009420 malate dehydrogenase; Provisional; Region: PRK05086 198214009421 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 198214009422 NAD binding site [chemical binding]; other site 198214009423 dimerization interface [polypeptide binding]; other site 198214009424 Substrate binding site [chemical binding]; other site 198214009425 arginine repressor; Provisional; Region: PRK05066 198214009426 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 198214009427 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 198214009428 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198214009429 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 198214009430 RNAase interaction site [polypeptide binding]; other site 198214009431 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 198214009432 Fusaric acid resistance protein family; Region: FUSC; pfam04632 198214009433 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 198214009434 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214009435 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214009436 efflux system membrane protein; Provisional; Region: PRK11594 198214009437 transcriptional regulator; Provisional; Region: PRK10632 198214009438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214009439 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198214009440 putative effector binding pocket; other site 198214009441 dimerization interface [polypeptide binding]; other site 198214009442 protease TldD; Provisional; Region: tldD; PRK10735 198214009443 hypothetical protein; Provisional; Region: PRK10899 198214009444 Protein of unknown function; Region: DUF3971; pfam13116 198214009445 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198214009446 ribonuclease G; Provisional; Region: PRK11712 198214009447 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 198214009448 homodimer interface [polypeptide binding]; other site 198214009449 oligonucleotide binding site [chemical binding]; other site 198214009450 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 198214009451 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 198214009452 active site 198214009453 dimer interface [polypeptide binding]; other site 198214009454 rod shape-determining protein MreD; Provisional; Region: PRK11060 198214009455 rod shape-determining protein MreC; Region: mreC; TIGR00219 198214009456 rod shape-determining protein MreB; Provisional; Region: PRK13927 198214009457 MreB and similar proteins; Region: MreB_like; cd10225 198214009458 nucleotide binding site [chemical binding]; other site 198214009459 Mg binding site [ion binding]; other site 198214009460 putative protofilament interaction site [polypeptide binding]; other site 198214009461 RodZ interaction site [polypeptide binding]; other site 198214009462 regulatory protein CsrD; Provisional; Region: PRK11059 198214009463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198214009464 metal binding site [ion binding]; metal-binding site 198214009465 active site 198214009466 I-site; other site 198214009467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198214009468 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 198214009469 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 198214009470 NADP binding site [chemical binding]; other site 198214009471 dimer interface [polypeptide binding]; other site 198214009472 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 198214009473 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198214009474 carboxyltransferase (CT) interaction site; other site 198214009475 biotinylation site [posttranslational modification]; other site 198214009476 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 198214009477 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198214009478 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198214009479 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198214009480 hypothetical protein; Provisional; Region: PRK10633 198214009481 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 198214009482 Na binding site [ion binding]; other site 198214009483 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 198214009484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214009485 S-adenosylmethionine binding site [chemical binding]; other site 198214009486 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198214009487 active site 198214009488 FMN binding site [chemical binding]; other site 198214009489 catalytic residues [active] 198214009490 substrate binding site [chemical binding]; other site 198214009491 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 198214009492 putative methyltransferase; Provisional; Region: PRK11524 198214009493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214009494 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 198214009495 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214009496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214009497 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 198214009498 substrate binding pocket [chemical binding]; other site 198214009499 membrane-bound complex binding site; other site 198214009500 hinge residues; other site 198214009501 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214009502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214009503 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214009504 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214009505 Similar to Escherichia coli K12 transport system permease gi: 1789669 (369 aa). BLAST with identity of 97% in 180 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214009506 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 198214009507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214009508 dimer interface [polypeptide binding]; other site 198214009509 conserved gate region; other site 198214009510 putative PBP binding loops; other site 198214009511 ABC-ATPase subunit interface; other site 198214009512 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198214009513 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198214009514 Walker A/P-loop; other site 198214009515 ATP binding site [chemical binding]; other site 198214009516 Q-loop/lid; other site 198214009517 ABC transporter signature motif; other site 198214009518 Walker B; other site 198214009519 D-loop; other site 198214009520 H-loop/switch region; other site 198214009521 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 198214009522 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 198214009523 trimer interface [polypeptide binding]; other site 198214009524 putative metal binding site [ion binding]; other site 198214009525 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 198214009526 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 198214009527 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 198214009528 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 198214009529 shikimate binding site; other site 198214009530 NAD(P) binding site [chemical binding]; other site 198214009531 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 198214009532 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198214009533 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 198214009534 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198214009535 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198214009536 hypothetical protein; Validated; Region: PRK03430 198214009537 hypothetical protein; Provisional; Region: PRK10736 198214009538 DNA protecting protein DprA; Region: dprA; TIGR00732 198214009539 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 198214009540 active site 198214009541 catalytic residues [active] 198214009542 metal binding site [ion binding]; metal-binding site 198214009543 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 198214009544 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 198214009545 putative active site [active] 198214009546 substrate binding site [chemical binding]; other site 198214009547 putative cosubstrate binding site; other site 198214009548 catalytic site [active] 198214009549 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 198214009550 substrate binding site [chemical binding]; other site 198214009551 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 198214009552 putative RNA binding site [nucleotide binding]; other site 198214009553 16S rRNA methyltransferase B; Provisional; Region: PRK10901 198214009554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214009555 S-adenosylmethionine binding site [chemical binding]; other site 198214009556 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 198214009557 TrkA-N domain; Region: TrkA_N; pfam02254 198214009558 TrkA-C domain; Region: TrkA_C; pfam02080 198214009559 TrkA-N domain; Region: TrkA_N; pfam02254 198214009560 TrkA-C domain; Region: TrkA_C; pfam02080 198214009561 Homeodomain-like domain; Region: HTH_23; pfam13384 198214009562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214009563 Transposase; Region: HTH_Tnp_1; pfam01527 198214009564 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214009565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214009566 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214009567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214009568 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214009569 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214009570 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214009571 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 198214009572 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 198214009573 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 198214009574 alphaNTD homodimer interface [polypeptide binding]; other site 198214009575 alphaNTD - beta interaction site [polypeptide binding]; other site 198214009576 alphaNTD - beta' interaction site [polypeptide binding]; other site 198214009577 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 198214009578 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 198214009579 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 198214009580 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214009581 RNA binding surface [nucleotide binding]; other site 198214009582 30S ribosomal protein S11; Validated; Region: PRK05309 198214009583 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 198214009584 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 198214009585 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 198214009586 SecY translocase; Region: SecY; pfam00344 198214009587 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 198214009588 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 198214009589 23S rRNA binding site [nucleotide binding]; other site 198214009590 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 198214009591 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 198214009592 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 198214009593 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 198214009594 23S rRNA interface [nucleotide binding]; other site 198214009595 5S rRNA interface [nucleotide binding]; other site 198214009596 L27 interface [polypeptide binding]; other site 198214009597 L5 interface [polypeptide binding]; other site 198214009598 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 198214009599 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198214009600 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198214009601 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 198214009602 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 198214009603 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 198214009604 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 198214009605 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 198214009606 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 198214009607 RNA binding site [nucleotide binding]; other site 198214009608 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 198214009609 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 198214009610 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 198214009611 23S rRNA interface [nucleotide binding]; other site 198214009612 putative translocon interaction site; other site 198214009613 signal recognition particle (SRP54) interaction site; other site 198214009614 L23 interface [polypeptide binding]; other site 198214009615 trigger factor interaction site; other site 198214009616 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 198214009617 23S rRNA interface [nucleotide binding]; other site 198214009618 5S rRNA interface [nucleotide binding]; other site 198214009619 putative antibiotic binding site [chemical binding]; other site 198214009620 L25 interface [polypeptide binding]; other site 198214009621 L27 interface [polypeptide binding]; other site 198214009622 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 198214009623 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 198214009624 G-X-X-G motif; other site 198214009625 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 198214009626 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 198214009627 protein-rRNA interface [nucleotide binding]; other site 198214009628 putative translocon binding site; other site 198214009629 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 198214009630 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 198214009631 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 198214009632 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 198214009633 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 198214009634 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 198214009635 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 198214009636 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 198214009637 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 198214009638 Ferritin-like domain; Region: Ferritin; pfam00210 198214009639 heme binding site [chemical binding]; other site 198214009640 ferroxidase pore; other site 198214009641 ferroxidase diiron center [ion binding]; other site 198214009642 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 198214009643 elongation factor Tu; Reviewed; Region: PRK00049 198214009644 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 198214009645 G1 box; other site 198214009646 GEF interaction site [polypeptide binding]; other site 198214009647 GTP/Mg2+ binding site [chemical binding]; other site 198214009648 Switch I region; other site 198214009649 G2 box; other site 198214009650 G3 box; other site 198214009651 Switch II region; other site 198214009652 G4 box; other site 198214009653 G5 box; other site 198214009654 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 198214009655 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 198214009656 Antibiotic Binding Site [chemical binding]; other site 198214009657 elongation factor G; Reviewed; Region: PRK00007 198214009658 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 198214009659 G1 box; other site 198214009660 putative GEF interaction site [polypeptide binding]; other site 198214009661 GTP/Mg2+ binding site [chemical binding]; other site 198214009662 Switch I region; other site 198214009663 G2 box; other site 198214009664 G3 box; other site 198214009665 Switch II region; other site 198214009666 G4 box; other site 198214009667 G5 box; other site 198214009668 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 198214009669 Elongation Factor G, domain II; Region: EFG_II; pfam14492 198214009670 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 198214009671 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 198214009672 30S ribosomal protein S7; Validated; Region: PRK05302 198214009673 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 198214009674 S17 interaction site [polypeptide binding]; other site 198214009675 S8 interaction site; other site 198214009676 16S rRNA interaction site [nucleotide binding]; other site 198214009677 streptomycin interaction site [chemical binding]; other site 198214009678 23S rRNA interaction site [nucleotide binding]; other site 198214009679 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 198214009680 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 198214009681 sulfur relay protein TusC; Validated; Region: PRK00211 198214009682 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 198214009683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 198214009684 YheO-like PAS domain; Region: PAS_6; pfam08348 198214009685 HTH domain; Region: HTH_22; pfam13309 198214009686 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 198214009687 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 198214009688 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198214009689 phi X174 lysis protein; Provisional; Region: PRK02793 198214009690 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 198214009691 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 198214009692 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 198214009693 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 198214009694 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 198214009695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214009696 ABC transporter; Region: ABC_tran_2; pfam12848 198214009697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214009698 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 198214009699 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 198214009700 putative hydrolase; Provisional; Region: PRK10985 198214009701 hypothetical protein; Provisional; Region: PRK04966 198214009702 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 198214009703 active site 198214009704 hypothetical protein; Provisional; Region: PRK10738 198214009705 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 198214009706 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198214009707 ligand binding site [chemical binding]; other site 198214009708 flexible hinge region; other site 198214009709 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 198214009710 putative switch regulator; other site 198214009711 non-specific DNA interactions [nucleotide binding]; other site 198214009712 DNA binding site [nucleotide binding] 198214009713 sequence specific DNA binding site [nucleotide binding]; other site 198214009714 putative cAMP binding site [chemical binding]; other site 198214009715 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 198214009716 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 198214009717 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198214009718 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 198214009719 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198214009720 inhibitor-cofactor binding pocket; inhibition site 198214009721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214009722 catalytic residue [active] 198214009723 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 198214009724 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198214009725 glutamine binding [chemical binding]; other site 198214009726 catalytic triad [active] 198214009727 cell filamentation protein Fic; Provisional; Region: PRK10347 198214009728 Protein of unknown function (DUF2559); Region: DUF2559; pfam10832 198214009729 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 198214009730 substrate binding site [chemical binding]; other site 198214009731 putative transporter; Provisional; Region: PRK03699 198214009732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214009733 putative substrate translocation pore; other site 198214009734 nitrite reductase subunit NirD; Provisional; Region: PRK14989 198214009735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214009736 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198214009737 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198214009738 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 198214009739 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 198214009740 nitrite transporter NirC; Provisional; Region: PRK11562 198214009741 siroheme synthase; Provisional; Region: cysG; PRK10637 198214009742 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 198214009743 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 198214009744 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 198214009745 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 198214009746 active site 198214009747 SAM binding site [chemical binding]; other site 198214009748 homodimer interface [polypeptide binding]; other site 198214009749 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 198214009750 Similar to Escherichia coli K12 amino acid/amine transport protein gi: 2367216 (463 aa). BLAST with identity of 99% in 462 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214009751 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 198214009752 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 198214009753 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 198214009754 dimer interface [polypeptide binding]; other site 198214009755 active site 198214009756 fructoselysine 3-epimerase; Provisional; Region: PRK09856 198214009757 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198214009758 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 198214009759 substrate binding site [chemical binding]; other site 198214009760 ATP binding site [chemical binding]; other site 198214009761 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 198214009762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214009763 DNA-binding site [nucleotide binding]; DNA binding site 198214009764 UTRA domain; Region: UTRA; pfam07702 198214009765 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 198214009766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198214009767 catalytic residue [active] 198214009768 Protein of unknown function; Region: YhfT; pfam10797 198214009769 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 198214009770 putative mutase; Provisional; Region: PRK12383 198214009771 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 198214009772 dimer interface [polypeptide binding]; other site 198214009773 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 198214009774 active site 198214009775 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198214009776 substrate binding site [chemical binding]; other site 198214009777 catalytic residue [active] 198214009778 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 198214009779 Helix-turn-helix domain; Region: HTH_41; pfam14502 198214009780 YhfZ C-terminal domain; Region: YhfZ_C; pfam14503 198214009781 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 198214009782 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 198214009783 active site 198214009784 HIGH motif; other site 198214009785 dimer interface [polypeptide binding]; other site 198214009786 KMSKS motif; other site 198214009787 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198214009788 phosphoglycolate phosphatase; Provisional; Region: PRK13222 198214009789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214009790 motif II; other site 198214009791 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 198214009792 substrate binding site [chemical binding]; other site 198214009793 hexamer interface [polypeptide binding]; other site 198214009794 metal binding site [ion binding]; metal-binding site 198214009795 DNA adenine methylase; Provisional; Region: PRK10904 198214009796 cell division protein DamX; Validated; Region: PRK10905 198214009797 Sporulation related domain; Region: SPOR; pfam05036 198214009798 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 198214009799 active site 198214009800 dimer interface [polypeptide binding]; other site 198214009801 metal binding site [ion binding]; metal-binding site 198214009802 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 198214009803 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 198214009804 ADP binding site [chemical binding]; other site 198214009805 magnesium binding site [ion binding]; other site 198214009806 putative shikimate binding site; other site 198214009807 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 198214009808 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198214009809 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 198214009810 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789794 (148 aa). BLAST with identity of 99% in 148 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214009811 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 198214009812 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 198214009813 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 198214009814 Transglycosylase; Region: Transgly; pfam00912 198214009815 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198214009816 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 198214009817 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198214009818 ADP-ribose binding site [chemical binding]; other site 198214009819 dimer interface [polypeptide binding]; other site 198214009820 active site 198214009821 nudix motif; other site 198214009822 metal binding site [ion binding]; metal-binding site 198214009823 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 198214009824 GMP/IMP nucleotidase; Provisional; Region: PRK14988 198214009825 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 198214009826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214009827 motif II; other site 198214009828 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214009829 RNA binding surface [nucleotide binding]; other site 198214009830 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 198214009831 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 198214009832 dimerization interface [polypeptide binding]; other site 198214009833 domain crossover interface; other site 198214009834 redox-dependent activation switch; other site 198214009835 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 198214009836 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 198214009837 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 198214009838 active site 198214009839 substrate-binding site [chemical binding]; other site 198214009840 metal-binding site [ion binding] 198214009841 ATP binding site [chemical binding]; other site 198214009842 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 198214009843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214009844 dimerization interface [polypeptide binding]; other site 198214009845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214009846 dimer interface [polypeptide binding]; other site 198214009847 phosphorylation site [posttranslational modification] 198214009848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214009849 ATP binding site [chemical binding]; other site 198214009850 Mg2+ binding site [ion binding]; other site 198214009851 G-X-G motif; other site 198214009852 osmolarity response regulator; Provisional; Region: ompR; PRK09468 198214009853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214009854 active site 198214009855 phosphorylation site [posttranslational modification] 198214009856 intermolecular recognition site; other site 198214009857 dimerization interface [polypeptide binding]; other site 198214009858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214009859 DNA binding site [nucleotide binding] 198214009860 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 198214009861 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 198214009862 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198214009863 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 198214009864 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 198214009865 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 198214009866 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 198214009867 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 198214009868 RNA binding site [nucleotide binding]; other site 198214009869 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 198214009870 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 198214009871 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 198214009872 G1 box; other site 198214009873 GTP/Mg2+ binding site [chemical binding]; other site 198214009874 Switch I region; other site 198214009875 G2 box; other site 198214009876 G3 box; other site 198214009877 Switch II region; other site 198214009878 G4 box; other site 198214009879 G5 box; other site 198214009880 Nucleoside recognition; Region: Gate; pfam07670 198214009881 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 198214009882 Nucleoside recognition; Region: Gate; pfam07670 198214009883 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 198214009884 putative transposase; Provisional; Region: PRK09857 198214009885 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 198214009886 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214009887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214009888 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214009889 HTH-like domain; Region: HTH_21; pfam13276 198214009890 Integrase core domain; Region: rve; pfam00665 198214009891 Integrase core domain; Region: rve_3; pfam13683 198214009892 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 198214009893 PemK-like protein; Region: PemK; pfam02452 198214009894 carboxylesterase BioH; Provisional; Region: PRK10349 198214009895 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198214009896 Putative lysophospholipase; Region: Hydrolase_4; cl19140 198214009897 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 198214009898 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214009899 active site 198214009900 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 198214009901 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 198214009902 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 198214009903 high-affinity gluconate transporter; Provisional; Region: PRK14984 198214009904 GntP family permease; Region: GntP_permease; pfam02447 198214009905 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 198214009906 4-alpha-glucanotransferase; Region: malQ; TIGR00217 198214009907 maltodextrin phosphorylase; Provisional; Region: PRK14985 198214009908 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 198214009909 active site pocket [active] 198214009910 Similar to Escherichia coli K12 positive regulator of mal regulon gi: 2367223 (902 aa). BLAST with identity of 99% in 894 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214009911 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 198214009912 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 198214009913 putative active site [active] 198214009914 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 198214009915 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 198214009916 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 198214009917 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 198214009918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214009919 Walker A motif; other site 198214009920 ATP binding site [chemical binding]; other site 198214009921 Walker B motif; other site 198214009922 arginine finger; other site 198214009923 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 198214009924 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198214009925 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214009926 intramembrane serine protease GlpG; Provisional; Region: PRK10907 198214009927 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 198214009928 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 198214009929 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 198214009930 active site residue [active] 198214009931 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 198214009932 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 198214009933 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214009934 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214009935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214009936 glycogen phosphorylase; Provisional; Region: PRK14986 198214009937 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 198214009938 homodimer interface [polypeptide binding]; other site 198214009939 active site pocket [active] 198214009940 glycogen synthase; Provisional; Region: glgA; PRK00654 198214009941 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 198214009942 ADP-binding pocket [chemical binding]; other site 198214009943 homodimer interface [polypeptide binding]; other site 198214009944 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 198214009945 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 198214009946 ligand binding site; other site 198214009947 oligomer interface; other site 198214009948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198214009949 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 198214009950 dimer interface [polypeptide binding]; other site 198214009951 N-terminal domain interface [polypeptide binding]; other site 198214009952 sulfate 1 binding site; other site 198214009953 glycogen debranching enzyme; Provisional; Region: PRK03705 198214009954 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 198214009955 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 198214009956 active site 198214009957 catalytic site [active] 198214009958 glycogen branching enzyme; Provisional; Region: PRK05402 198214009959 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 198214009960 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 198214009961 active site 198214009962 catalytic site [active] 198214009963 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 198214009964 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 198214009965 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 198214009966 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 198214009967 putative antibiotic transporter; Provisional; Region: PRK10739 198214009968 low affinity gluconate transporter; Provisional; Region: PRK10472 198214009969 GntP family permease; Region: GntP_permease; pfam02447 198214009970 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 198214009971 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 198214009972 ATP-binding site [chemical binding]; other site 198214009973 Gluconate-6-phosphate binding site [chemical binding]; other site 198214009974 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 198214009975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214009976 DNA binding site [nucleotide binding] 198214009977 domain linker motif; other site 198214009978 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 198214009979 putative ligand binding site [chemical binding]; other site 198214009980 putative dimerization interface [polypeptide binding]; other site 198214009981 Pirin-related protein [General function prediction only]; Region: COG1741 198214009982 Pirin; Region: Pirin; pfam02678 198214009983 putative oxidoreductase; Provisional; Region: PRK10206 198214009984 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198214009985 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198214009986 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198214009987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214009988 Coenzyme A binding pocket [chemical binding]; other site 198214009989 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 198214009990 hypothetical protein; Provisional; Region: PRK10350 198214009991 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 198214009992 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 198214009993 putative active site [active] 198214009994 catalytic site [active] 198214009995 putative metal binding site [ion binding]; other site 198214009996 Similar to Escherichia coli K12 ATP-binding component of sn-glycerol 3-phosphate transport system gi: 1789859 (370 aa). BLAST with identity of 96% in 789 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214009997 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214009998 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198214009999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010000 dimer interface [polypeptide binding]; other site 198214010001 conserved gate region; other site 198214010002 putative PBP binding loops; other site 198214010003 ABC-ATPase subunit interface; other site 198214010004 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198214010005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010006 dimer interface [polypeptide binding]; other site 198214010007 conserved gate region; other site 198214010008 putative PBP binding loops; other site 198214010009 ABC-ATPase subunit interface; other site 198214010010 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 198214010011 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198214010012 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 198214010013 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 198214010014 Walker A/P-loop; other site 198214010015 ATP binding site [chemical binding]; other site 198214010016 Q-loop/lid; other site 198214010017 ABC transporter signature motif; other site 198214010018 Walker B; other site 198214010019 D-loop; other site 198214010020 H-loop/switch region; other site 198214010021 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 198214010022 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 198214010023 Walker A/P-loop; other site 198214010024 ATP binding site [chemical binding]; other site 198214010025 Q-loop/lid; other site 198214010026 ABC transporter signature motif; other site 198214010027 Walker B; other site 198214010028 D-loop; other site 198214010029 H-loop/switch region; other site 198214010030 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 198214010031 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 198214010032 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 198214010033 TM-ABC transporter signature motif; other site 198214010034 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 198214010035 TM-ABC transporter signature motif; other site 198214010036 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 198214010037 dimerization interface [polypeptide binding]; other site 198214010038 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 198214010039 ligand binding site [chemical binding]; other site 198214010040 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 198214010041 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 198214010042 dimerization interface [polypeptide binding]; other site 198214010043 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 198214010044 ligand binding site [chemical binding]; other site 198214010045 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 198214010046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198214010047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198214010048 DNA binding residues [nucleotide binding] 198214010049 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 198214010050 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 198214010051 cell division protein FtsE; Provisional; Region: PRK10908 198214010052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214010053 Walker A/P-loop; other site 198214010054 ATP binding site [chemical binding]; other site 198214010055 Q-loop/lid; other site 198214010056 ABC transporter signature motif; other site 198214010057 Walker B; other site 198214010058 D-loop; other site 198214010059 H-loop/switch region; other site 198214010060 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 198214010061 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 198214010062 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 198214010063 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198214010064 P loop; other site 198214010065 GTP binding site [chemical binding]; other site 198214010066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214010067 S-adenosylmethionine binding site [chemical binding]; other site 198214010068 hypothetical protein; Provisional; Region: PRK10910 198214010069 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 198214010070 Predicted membrane protein [Function unknown]; Region: COG3714 198214010071 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 198214010072 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198214010073 metal-binding site [ion binding] 198214010074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198214010075 Soluble P-type ATPase [General function prediction only]; Region: COG4087 198214010076 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 198214010077 CPxP motif; other site 198214010078 hypothetical protein; Provisional; Region: PRK11212 198214010079 hypothetical protein; Provisional; Region: PRK11615 198214010080 major facilitator superfamily transporter; Provisional; Region: PRK05122 198214010081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010082 putative substrate translocation pore; other site 198214010083 Domain of unknown function DUF20; Region: UPF0118; cl00465 198214010084 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 198214010085 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 198214010086 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198214010087 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 198214010088 substrate binding site [chemical binding]; other site 198214010089 nickel transporter permease NikB; Provisional; Region: PRK10352 198214010090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010091 dimer interface [polypeptide binding]; other site 198214010092 conserved gate region; other site 198214010093 putative PBP binding loops; other site 198214010094 ABC-ATPase subunit interface; other site 198214010095 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 198214010096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010097 dimer interface [polypeptide binding]; other site 198214010098 conserved gate region; other site 198214010099 putative PBP binding loops; other site 198214010100 ABC-ATPase subunit interface; other site 198214010101 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 198214010102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214010103 Walker A/P-loop; other site 198214010104 ATP binding site [chemical binding]; other site 198214010105 Q-loop/lid; other site 198214010106 ABC transporter signature motif; other site 198214010107 Walker B; other site 198214010108 D-loop; other site 198214010109 H-loop/switch region; other site 198214010110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214010111 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 198214010112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214010113 Walker A/P-loop; other site 198214010114 ATP binding site [chemical binding]; other site 198214010115 Q-loop/lid; other site 198214010116 ABC transporter signature motif; other site 198214010117 Walker B; other site 198214010118 D-loop; other site 198214010119 H-loop/switch region; other site 198214010120 nickel responsive regulator; Provisional; Region: PRK02967 198214010121 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 198214010122 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 198214010123 HicB family; Region: HicB; pfam05534 198214010124 Structural glycoprotein p40/gp41 conserved region; Region: Baculo_gp41; pfam04700 198214010125 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198214010126 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198214010127 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198214010128 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198214010129 Walker A/P-loop; other site 198214010130 ATP binding site [chemical binding]; other site 198214010131 Q-loop/lid; other site 198214010132 ABC transporter signature motif; other site 198214010133 Walker B; other site 198214010134 D-loop; other site 198214010135 H-loop/switch region; other site 198214010136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214010137 Walker A/P-loop; other site 198214010138 ATP binding site [chemical binding]; other site 198214010139 Q-loop/lid; other site 198214010140 ABC transporter signature motif; other site 198214010141 Walker B; other site 198214010142 D-loop; other site 198214010143 H-loop/switch region; other site 198214010144 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198214010145 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 198214010146 HlyD family secretion protein; Region: HlyD; pfam00529 198214010147 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214010148 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214010149 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 198214010150 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 198214010151 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1789905 (384 aa). BLAST with identity of 96% in 375 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 198214010153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198214010154 DNA binding site [nucleotide binding] 198214010155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198214010156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214010157 DNA binding residues [nucleotide binding] 198214010158 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 198214010159 Outer membrane usher protein; Region: Usher; pfam00577 198214010160 PapC C-terminal domain; Region: PapC_C; pfam13953 198214010161 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214010162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010163 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214010164 HTH-like domain; Region: HTH_21; pfam13276 198214010165 Integrase core domain; Region: rve; pfam00665 198214010166 Integrase core domain; Region: rve_3; pfam13683 198214010167 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198214010168 eyelet of channel; other site 198214010169 trimer interface [polypeptide binding]; other site 198214010170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010171 Transposase; Region: HTH_Tnp_1; pfam01527 198214010172 putative transposase OrfB; Reviewed; Region: PHA02517 198214010173 HTH-like domain; Region: HTH_21; pfam13276 198214010174 Integrase core domain; Region: rve; pfam00665 198214010175 Integrase core domain; Region: rve_2; pfam13333 198214010176 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010177 Similar to Escherichia coli K12 transport system permease gi: 1789669 (369 aa). BLAST with identity of 99% in 187 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214010178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214010179 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 198214010180 substrate binding pocket [chemical binding]; other site 198214010181 membrane-bound complex binding site; other site 198214010182 hinge residues; other site 198214010183 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010184 Predicted flavoproteins [General function prediction only]; Region: COG2081 198214010185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214010186 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198214010187 universal stress protein UspB; Provisional; Region: PRK04960 198214010188 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198214010189 Ligand Binding Site [chemical binding]; other site 198214010190 Similar to Escherichia coli K12 transport protein gi: 1789911 (490 aa). BLAST with identity of 98% in 489 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010191 putative methyltransferase; Provisional; Region: PRK10742 198214010192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214010193 S-adenosylmethionine binding site [chemical binding]; other site 198214010194 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 198214010195 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 198214010196 active site 198214010197 Zn binding site [ion binding]; other site 198214010198 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 198214010199 glutathione reductase; Validated; Region: PRK06116 198214010200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214010201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214010202 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198214010203 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010205 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010206 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198214010208 dimerization interface [polypeptide binding]; other site 198214010209 putative DNA binding site [nucleotide binding]; other site 198214010210 putative Zn2+ binding site [ion binding]; other site 198214010211 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 198214010212 Citrate transporter; Region: CitMHS; pfam03600 198214010213 transmembrane helices; other site 198214010214 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 198214010215 catalytic residues [active] 198214010216 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010217 Predicted permeases [General function prediction only]; Region: COG0701 198214010218 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 198214010219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198214010220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214010221 DNA binding residues [nucleotide binding] 198214010222 dimerization interface [polypeptide binding]; other site 198214010223 Similar to Escherichia coli K12 transport ATPase gi: 1789924 (216 aa). BLAST with identity of 99% in 215 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214010224 acid-resistance protein; Provisional; Region: hdeB; PRK11566 198214010225 acid-resistance protein; Provisional; Region: PRK10208 198214010226 acid-resistance membrane protein; Provisional; Region: PRK10209 198214010227 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 198214010228 Similar to Escherichia coli K12 membrane protein gi: 1789929 (386 aa). BLAST with identity of 99% in 302 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214010229 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010231 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010232 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010233 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 198214010234 trehalase; Provisional; Region: treF; PRK13270 198214010235 Similar to Shigella flexneri conserved hypothetical protein ref: NP_085397.1 (448 aa). BLAST with identity of 77% in 448 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198214010237 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214010238 DNA binding residues [nucleotide binding] 198214010239 dimerization interface [polypeptide binding]; other site 198214010240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198214010241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214010242 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 198214010243 putative effector binding pocket; other site 198214010244 putative dimerization interface [polypeptide binding]; other site 198214010245 inner membrane protein YhjD; Region: TIGR00766 198214010246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010247 metabolite-proton symporter; Region: 2A0106; TIGR00883 198214010248 putative substrate translocation pore; other site 198214010249 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 198214010250 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198214010251 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198214010252 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198214010253 substrate binding site [chemical binding]; other site 198214010254 ATP binding site [chemical binding]; other site 198214010255 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198214010256 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198214010257 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 198214010258 putative diguanylate cyclase; Provisional; Region: PRK13561 198214010259 HAMP domain; Region: HAMP; pfam00672 198214010260 diguanylate cyclase; Region: GGDEF; smart00267 198214010261 metal binding site [ion binding]; metal-binding site 198214010262 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198214010263 Similar to Escherichia coli K12 oxidoreductase subunit gi: 2367239 (1167 aa). BLAST with identity of 98% in 785 aa. This CDS contains deletion. The sequence has been checked and is believed to be correct. 198214010264 endo-1,4-D-glucanase; Provisional; Region: PRK11097 198214010265 cellulose synthase regulator protein; Provisional; Region: PRK11114 198214010266 Similar to Escherichia coli K12 cellulose synthase gi: 2367240 (889 aa). BLAST with identity of 98% in 888 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010267 cell division protein; Provisional; Region: PRK10037 198214010268 YhjQ protein; Region: YhjQ; pfam06564 198214010269 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010271 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010272 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010273 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 198214010274 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 198214010275 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 198214010276 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 198214010277 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 198214010278 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 198214010279 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198214010280 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 198214010281 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 198214010282 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214010283 Walker A/P-loop; other site 198214010284 ATP binding site [chemical binding]; other site 198214010285 Q-loop/lid; other site 198214010286 ABC transporter signature motif; other site 198214010287 Walker B; other site 198214010288 D-loop; other site 198214010289 H-loop/switch region; other site 198214010290 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214010291 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 198214010292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198214010293 Walker A/P-loop; other site 198214010294 ATP binding site [chemical binding]; other site 198214010295 Q-loop/lid; other site 198214010296 ABC transporter signature motif; other site 198214010297 Walker B; other site 198214010298 D-loop; other site 198214010299 H-loop/switch region; other site 198214010300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198214010301 dipeptide transporter; Provisional; Region: PRK10913 198214010302 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198214010303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010304 dimer interface [polypeptide binding]; other site 198214010305 conserved gate region; other site 198214010306 putative PBP binding loops; other site 198214010307 ABC-ATPase subunit interface; other site 198214010308 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198214010309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010310 dimer interface [polypeptide binding]; other site 198214010311 conserved gate region; other site 198214010312 putative PBP binding loops; other site 198214010313 ABC-ATPase subunit interface; other site 198214010314 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 198214010315 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 198214010316 peptide binding site [polypeptide binding]; other site 198214010317 phosphoethanolamine transferase; Provisional; Region: PRK11560 198214010318 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198214010319 Sulfatase; Region: Sulfatase; pfam00884 198214010320 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 198214010321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010322 putative substrate translocation pore; other site 198214010323 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 198214010324 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 198214010325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198214010326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214010327 Coenzyme A binding pocket [chemical binding]; other site 198214010328 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 198214010329 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 198214010330 molybdopterin cofactor binding site [chemical binding]; other site 198214010331 substrate binding site [chemical binding]; other site 198214010332 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 198214010333 molybdopterin cofactor binding site; other site 198214010334 putative outer membrane lipoprotein; Provisional; Region: PRK10510 198214010335 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198214010336 ligand binding site [chemical binding]; other site 198214010337 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 198214010338 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 198214010339 dimerization interface [polypeptide binding]; other site 198214010340 ligand binding site [chemical binding]; other site 198214010341 NADP binding site [chemical binding]; other site 198214010342 catalytic site [active] 198214010343 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 198214010344 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198214010345 DNA-binding site [nucleotide binding]; DNA binding site 198214010346 RNA-binding motif; other site 198214010347 putative transposase OrfB; Reviewed; Region: PHA02517 198214010348 HTH-like domain; Region: HTH_21; pfam13276 198214010349 Integrase core domain; Region: rve; pfam00665 198214010350 Integrase core domain; Region: rve_2; pfam13333 198214010351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010352 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214010353 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214010354 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010355 Haem-binding domain; Region: Haem_bd; pfam14376 198214010356 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 198214010357 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 198214010358 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 198214010359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214010360 catalytic residue [active] 198214010361 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 198214010362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214010363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214010364 transcriptional regulator YdeO; Provisional; Region: PRK09940 198214010365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214010366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214010367 Similar to Escherichia coli K12 membrane protein gi: 1789929 (386 aa). BLAST with identity of 99% in 85 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214010368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010369 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010370 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010371 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010372 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 198214010373 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 198214010374 DALR anticodon binding domain; Region: DALR_1; pfam05746 198214010375 anticodon binding site; other site 198214010376 tRNA binding surface [nucleotide binding]; other site 198214010377 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 198214010378 dimer interface [polypeptide binding]; other site 198214010379 motif 1; other site 198214010380 active site 198214010381 motif 2; other site 198214010382 motif 3; other site 198214010383 YsaB-like lipoprotein; Region: YsaB; pfam13983 198214010384 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 198214010385 hypothetical protein; Provisional; Region: PRK11383 198214010386 yiaA/B two helix domain; Region: YiaAB; pfam05360 198214010387 yiaA/B two helix domain; Region: YiaAB; pfam05360 198214010388 hypothetical protein; Provisional; Region: PRK11403 198214010389 yiaA/B two helix domain; Region: YiaAB; pfam05360 198214010390 xylulokinase; Provisional; Region: PRK15027 198214010391 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 198214010392 N- and C-terminal domain interface [polypeptide binding]; other site 198214010393 active site 198214010394 MgATP binding site [chemical binding]; other site 198214010395 catalytic site [active] 198214010396 metal binding site [ion binding]; metal-binding site 198214010397 xylulose binding site [chemical binding]; other site 198214010398 homodimer interface [polypeptide binding]; other site 198214010399 Similar to Escherichia coli K12 D-xylose isomerase gi: 1789988 (441 aa). BLAST with identity of 99% in 440 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010400 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 198214010401 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 198214010402 putative ligand binding site [chemical binding]; other site 198214010403 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 198214010404 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198214010405 Walker A/P-loop; other site 198214010406 ATP binding site [chemical binding]; other site 198214010407 Q-loop/lid; other site 198214010408 ABC transporter signature motif; other site 198214010409 Walker B; other site 198214010410 D-loop; other site 198214010411 H-loop/switch region; other site 198214010412 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198214010413 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214010414 TM-ABC transporter signature motif; other site 198214010415 Similar to Escherichia coli K12 regulator of xyl operon gi: 1789993 (393 aa). BLAST with identity of 99% in 393 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010416 hypothetical protein; Provisional; Region: PRK10356 198214010417 Lysozyme subfamily 2; Region: LYZ2; smart00047 198214010418 alpha-amylase; Reviewed; Region: malS; PRK09505 198214010419 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 198214010420 active site 198214010421 catalytic site [active] 198214010422 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 198214010423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214010424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214010425 homodimer interface [polypeptide binding]; other site 198214010426 catalytic residue [active] 198214010427 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198214010428 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214010429 Transcriptional regulator [Transcription]; Region: IclR; COG1414 198214010430 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198214010431 Bacterial transcriptional regulator; Region: IclR; pfam01614 198214010432 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 198214010433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010434 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010435 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010436 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010437 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790002 (158 aa). BLAST with identity of 99% in 106 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214010438 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 198214010439 DctM-like transporters; Region: DctM; pfam06808 198214010440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010441 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010442 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010443 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010444 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 198214010445 NAD(P) binding site [chemical binding]; other site 198214010446 catalytic residues [active] 198214010447 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 198214010448 dimer interface [polypeptide binding]; other site 198214010449 active site 198214010450 metal binding site [ion binding]; metal-binding site 198214010451 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 198214010452 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 198214010453 G1 box; other site 198214010454 putative GEF interaction site [polypeptide binding]; other site 198214010455 GTP/Mg2+ binding site [chemical binding]; other site 198214010456 Switch I region; other site 198214010457 G2 box; other site 198214010458 G3 box; other site 198214010459 Switch II region; other site 198214010460 G4 box; other site 198214010461 G5 box; other site 198214010462 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 198214010463 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 198214010464 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 198214010465 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 198214010466 selenocysteine synthase; Provisional; Region: PRK04311 198214010467 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 198214010468 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 198214010469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198214010470 catalytic residue [active] 198214010471 putative glutathione S-transferase; Provisional; Region: PRK10357 198214010472 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 198214010473 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 198214010474 dimer interface [polypeptide binding]; other site 198214010475 N-terminal domain interface [polypeptide binding]; other site 198214010476 putative substrate binding pocket (H-site) [chemical binding]; other site 198214010477 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 198214010478 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214010479 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214010480 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 198214010481 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 198214010482 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 198214010483 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 198214010484 active site 198214010485 P-loop; other site 198214010486 phosphorylation site [posttranslational modification] 198214010487 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214010488 active site 198214010489 phosphorylation site [posttranslational modification] 198214010490 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 198214010491 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198214010492 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198214010493 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 198214010494 hypothetical protein; Provisional; Region: PRK11020 198214010495 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010497 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010498 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010499 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 198214010500 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198214010501 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 198214010502 trimer interface [polypeptide binding]; other site 198214010503 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 198214010504 trimer interface [polypeptide binding]; other site 198214010505 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 198214010506 trimer interface [polypeptide binding]; other site 198214010507 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 198214010508 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 198214010509 trimer interface [polypeptide binding]; other site 198214010510 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 198214010511 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 198214010512 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 198214010513 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 198214010514 L-lactate permease; Provisional; Region: PRK10420 198214010515 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 198214010516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214010517 DNA-binding site [nucleotide binding]; DNA binding site 198214010518 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214010519 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 198214010520 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 198214010521 active site 198214010522 substrate binding site [chemical binding]; other site 198214010523 FMN binding site [chemical binding]; other site 198214010524 putative catalytic residues [active] 198214010525 putative rRNA methylase; Provisional; Region: PRK10358 198214010526 serine acetyltransferase; Provisional; Region: cysE; PRK11132 198214010527 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 198214010528 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 198214010529 trimer interface [polypeptide binding]; other site 198214010530 active site 198214010531 substrate binding site [chemical binding]; other site 198214010532 CoA binding site [chemical binding]; other site 198214010533 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 198214010534 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 198214010535 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 198214010536 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 198214010537 SecA binding site; other site 198214010538 Preprotein binding site; other site 198214010539 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 198214010540 GSH binding site [chemical binding]; other site 198214010541 catalytic residues [active] 198214010542 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198214010543 active site residue [active] 198214010544 phosphoglyceromutase; Provisional; Region: PRK05434 198214010545 AmiB activator; Provisional; Region: PRK11637 198214010546 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198214010547 HemX; Region: HemX; cl19375 198214010548 Peptidase family M23; Region: Peptidase_M23; pfam01551 198214010549 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 198214010550 putative active site [active] 198214010551 NodB motif; other site 198214010552 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010554 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010555 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010556 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 198214010557 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 198214010558 NAD(P) binding site [chemical binding]; other site 198214010559 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 198214010560 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 198214010561 substrate-cofactor binding pocket; other site 198214010562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214010563 catalytic residue [active] 198214010564 hypothetical protein; Provisional; Region: PRK11346 198214010565 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 198214010566 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 198214010567 NADP binding site [chemical binding]; other site 198214010568 homopentamer interface [polypeptide binding]; other site 198214010569 substrate binding site [chemical binding]; other site 198214010570 active site 198214010571 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198214010572 putative active site [active] 198214010573 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198214010574 putative active site [active] 198214010575 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 198214010576 O-antigen ligase RfaL; Provisional; Region: PRK15487 198214010577 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 198214010578 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198214010579 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 198214010580 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 198214010581 Ligand binding site; other site 198214010582 metal-binding site 198214010583 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 198214010584 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 198214010585 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 198214010586 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 198214010587 Ligand binding site; other site 198214010588 metal-binding site 198214010589 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 198214010590 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 198214010591 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198214010592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198214010593 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198214010594 putative active site [active] 198214010595 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010597 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010598 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010599 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 198214010600 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 198214010601 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 198214010602 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 198214010603 active site 198214010604 (T/H)XGH motif; other site 198214010605 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 198214010606 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 198214010607 DNA binding site [nucleotide binding] 198214010608 catalytic residue [active] 198214010609 H2TH interface [polypeptide binding]; other site 198214010610 putative catalytic residues [active] 198214010611 turnover-facilitating residue; other site 198214010612 intercalation triad [nucleotide binding]; other site 198214010613 8OG recognition residue [nucleotide binding]; other site 198214010614 putative reading head residues; other site 198214010615 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198214010616 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198214010617 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 198214010618 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 198214010619 hypothetical protein; Reviewed; Region: PRK00024 198214010620 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 198214010621 MPN+ (JAMM) motif; other site 198214010622 Zinc-binding site [ion binding]; other site 198214010623 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 198214010624 Flavoprotein; Region: Flavoprotein; cl19190 198214010625 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 198214010626 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 198214010627 trimer interface [polypeptide binding]; other site 198214010628 active site 198214010629 division inhibitor protein; Provisional; Region: slmA; PRK09480 198214010630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214010631 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198214010632 active site 198214010633 ribonuclease PH; Reviewed; Region: rph; PRK00173 198214010634 Ribonuclease PH; Region: RNase_PH_bact; cd11362 198214010635 hexamer interface [polypeptide binding]; other site 198214010636 active site 198214010637 hypothetical protein; Provisional; Region: PRK11820 198214010638 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 198214010639 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 198214010640 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 198214010641 BRO family, N-terminal domain; Region: Bro-N; pfam02498 198214010642 Predicted membrane protein [Function unknown]; Region: COG2860 198214010643 UPF0126 domain; Region: UPF0126; pfam03458 198214010644 UPF0126 domain; Region: UPF0126; pfam03458 198214010645 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 198214010646 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 198214010647 nucleotide binding pocket [chemical binding]; other site 198214010648 K-X-D-G motif; other site 198214010649 catalytic site [active] 198214010650 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 198214010651 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 198214010652 Guanylate kinase; Region: Guanylate_kin; pfam00625 198214010653 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 198214010654 catalytic site [active] 198214010655 G-X2-G-X-G-K; other site 198214010656 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 198214010657 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 198214010658 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198214010659 Zn2+ binding site [ion binding]; other site 198214010660 Mg2+ binding site [ion binding]; other site 198214010661 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198214010662 synthetase active site [active] 198214010663 NTP binding site [chemical binding]; other site 198214010664 metal binding site [ion binding]; metal-binding site 198214010665 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 198214010666 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 198214010667 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 198214010668 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198214010669 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 198214010670 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 198214010671 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 198214010672 generic binding surface II; other site 198214010673 ssDNA binding site; other site 198214010674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214010675 ATP binding site [chemical binding]; other site 198214010676 putative Mg++ binding site [ion binding]; other site 198214010677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214010678 nucleotide binding region [chemical binding]; other site 198214010679 ATP-binding site [chemical binding]; other site 198214010680 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 198214010681 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 198214010682 Sulfate transporter family; Region: Sulfate_transp; cl19250 198214010683 AsmA family; Region: AsmA; pfam05170 198214010684 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 198214010685 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198214010686 putative alpha-glucosidase; Provisional; Region: PRK10658 198214010687 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 198214010688 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 198214010689 active site 198214010690 homotrimer interface [polypeptide binding]; other site 198214010691 catalytic site [active] 198214010692 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 198214010693 Similar to Escherichia coli K12 permease gi: 2367257 (480 aa). BLAST with identity of 99% in 480 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010694 SHI-2 198214010695 integrase; Provisional; Region: PRK09692 198214010696 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198214010697 active site 198214010698 Int/Topo IB signature motif; other site 198214010699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198214010700 TPR motif; other site 198214010701 binding surface 198214010702 Transposase; Region: HTH_Tnp_1; cl17663 198214010703 Transposase; Region: HTH_Tnp_1; cl17663 198214010704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010705 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214010706 HTH-like domain; Region: HTH_21; pfam13276 198214010707 Integrase core domain; Region: rve; pfam00665 198214010708 Integrase core domain; Region: rve_3; pfam13683 198214010709 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214010710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010711 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010712 Transposase DNA-binding; Region: Tnp_DNA_bind; pfam14706 198214010713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010714 putative substrate translocation pore; other site 198214010715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198214010716 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198214010717 IucA / IucC family; Region: IucA_IucC; pfam04183 198214010718 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198214010719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 198214010720 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 198214010721 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198214010722 IucA / IucC family; Region: IucA_IucC; pfam04183 198214010723 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198214010724 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 198214010725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 198214010726 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 198214010727 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198214010728 N-terminal plug; other site 198214010729 ligand-binding site [chemical binding]; other site 198214010730 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198214010731 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214010732 HTH-like domain; Region: HTH_21; pfam13276 198214010733 Integrase core domain; Region: rve; pfam00665 198214010734 Integrase core domain; Region: rve_3; pfam13683 198214010735 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214010736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010737 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 198214010738 PapC N-terminal domain; Region: PapC_N; pfam13954 198214010739 Outer membrane usher protein; Region: Usher; pfam00577 198214010740 PapC C-terminal domain; Region: PapC_C; pfam13953 198214010741 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010743 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010744 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010745 Fimbrial protein; Region: Fimbrial; cl01416 198214010746 phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918 198214010747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214010748 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 198214010749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010750 dimer interface [polypeptide binding]; other site 198214010751 conserved gate region; other site 198214010752 putative PBP binding loops; other site 198214010753 ABC-ATPase subunit interface; other site 198214010754 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 198214010755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214010756 dimer interface [polypeptide binding]; other site 198214010757 conserved gate region; other site 198214010758 putative PBP binding loops; other site 198214010759 ABC-ATPase subunit interface; other site 198214010760 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 198214010761 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 198214010762 Walker A/P-loop; other site 198214010763 ATP binding site [chemical binding]; other site 198214010764 Q-loop/lid; other site 198214010765 ABC transporter signature motif; other site 198214010766 Walker B; other site 198214010767 D-loop; other site 198214010768 H-loop/switch region; other site 198214010769 transcriptional regulator PhoU; Provisional; Region: PRK11115 198214010770 PhoU domain; Region: PhoU; pfam01895 198214010771 PhoU domain; Region: PhoU; pfam01895 198214010772 transcriptional antiterminator BglG; Provisional; Region: PRK09772 198214010773 CAT RNA binding domain; Region: CAT_RBD; pfam03123 198214010774 PRD domain; Region: PRD; pfam00874 198214010775 PRD domain; Region: PRD; pfam00874 198214010776 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 198214010777 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198214010778 active site turn [active] 198214010779 phosphorylation site [posttranslational modification] 198214010780 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198214010781 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198214010782 HPr interaction site; other site 198214010783 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198214010784 active site 198214010785 phosphorylation site [posttranslational modification] 198214010786 Similar to Escherichia coli K12 phospho-beta-glucosidase B; cryptic gi: 2367270 (471 aa). BLAST with identity of 98% in 729 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214010787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010788 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010789 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010790 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010791 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 198214010792 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 198214010793 maltoporin; Provisional; Region: lamB; PRK09360 198214010794 trimer interface; other site 198214010795 sugar binding site [chemical binding]; other site 198214010796 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 198214010797 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 198214010798 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 198214010799 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198214010800 active site 198214010801 trimer interface [polypeptide binding]; other site 198214010802 allosteric site; other site 198214010803 active site lid [active] 198214010804 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790153 (196 aa). BLAST with identity of 98% in 888 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214010805 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214010806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214010807 Homeodomain-like domain; Region: HTH_23; pfam13384 198214010808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010809 Transposase; Region: HTH_Tnp_1; pfam01527 198214010810 putative inner membrane protein; Provisional; Region: PRK09823 198214010811 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 198214010812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214010813 active site 198214010814 motif I; other site 198214010815 motif II; other site 198214010816 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198214010817 Predicted flavoprotein [General function prediction only]; Region: COG0431 198214010818 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 198214010819 Similar to Escherichia coli K12 transcriptional regulator LYSR-type gi: 1790147 (320 aa). BLAST with identity of 97% in 742 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214010820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010821 Transposase; Region: HTH_Tnp_1; pfam01527 198214010822 putative transposase OrfB; Reviewed; Region: PHA02517 198214010823 HTH-like domain; Region: HTH_21; pfam13276 198214010824 Integrase core domain; Region: rve; pfam00665 198214010825 Integrase core domain; Region: rve_3; pfam13683 198214010826 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 198214010827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010828 putative substrate translocation pore; other site 198214010829 tryptophan permease TnaB; Provisional; Region: PRK09664 198214010830 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198214010831 Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033 198214010832 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 198214010833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198214010834 catalytic residue [active] 198214010835 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 198214010836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214010837 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214010838 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214010839 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214010840 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 198214010841 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 198214010842 trmE is a tRNA modification GTPase; Region: trmE; cd04164 198214010843 G1 box; other site 198214010844 GTP/Mg2+ binding site [chemical binding]; other site 198214010845 Switch I region; other site 198214010846 G2 box; other site 198214010847 Switch II region; other site 198214010848 G3 box; other site 198214010849 G4 box; other site 198214010850 G5 box; other site 198214010851 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 198214010852 membrane protein insertase; Provisional; Region: PRK01318 198214010853 YidC periplasmic domain; Region: YidC_periplas; pfam14849 198214010854 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 198214010855 ribonuclease P; Reviewed; Region: rnpA; PRK01732 198214010856 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 198214010857 DNA polymerase III subunit beta; Validated; Region: PRK05643 198214010858 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 198214010859 putative DNA binding surface [nucleotide binding]; other site 198214010860 dimer interface [polypeptide binding]; other site 198214010861 beta-clamp/clamp loader binding surface; other site 198214010862 beta-clamp/translesion DNA polymerase binding surface; other site 198214010863 recF protein; Region: recf; TIGR00611 198214010864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198214010865 Walker A/P-loop; other site 198214010866 ATP binding site [chemical binding]; other site 198214010867 Q-loop/lid; other site 198214010868 ABC transporter signature motif; other site 198214010869 Walker B; other site 198214010870 D-loop; other site 198214010871 H-loop/switch region; other site 198214010872 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 198214010873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214010874 ATP binding site [chemical binding]; other site 198214010875 Mg2+ binding site [ion binding]; other site 198214010876 G-X-G motif; other site 198214010877 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198214010878 anchoring element; other site 198214010879 dimer interface [polypeptide binding]; other site 198214010880 ATP binding site [chemical binding]; other site 198214010881 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 198214010882 active site 198214010883 putative metal-binding site [ion binding]; other site 198214010884 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198214010885 hypothetical protein; Provisional; Region: PRK11426 198214010886 sugar phosphate phosphatase; Provisional; Region: PRK10513 198214010887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214010888 active site 198214010889 motif I; other site 198214010890 motif II; other site 198214010891 hypothetical protein; Provisional; Region: PRK10215 198214010892 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198214010893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214010894 DNA-binding site [nucleotide binding]; DNA binding site 198214010895 FCD domain; Region: FCD; pfam07729 198214010896 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 198214010897 Similar to Escherichia coli K12 2-oxo-3-deoxygalactonate 6-phosphate aldolase and galactonate dehydratase gi: 2367262 (588 aa). BLAST with identity of 97% in 588 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010899 D-galactonate transporter; Region: 2A0114; TIGR00893 198214010900 putative substrate translocation pore; other site 198214010901 putative oxidoreductase; Provisional; Region: PRK11445 198214010902 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 198214010903 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 198214010904 hypothetical protein; Provisional; Region: PRK11616 198214010905 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198214010906 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 198214010907 putative dimer interface [polypeptide binding]; other site 198214010908 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198214010909 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 198214010910 putative dimer interface [polypeptide binding]; other site 198214010911 putative transporter; Validated; Region: PRK03818 198214010912 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 198214010913 TrkA-C domain; Region: TrkA_C; pfam02080 198214010914 TrkA-C domain; Region: TrkA_C; pfam02080 198214010915 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 198214010916 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198214010917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214010918 DNA-binding site [nucleotide binding]; DNA binding site 198214010919 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 198214010920 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 198214010921 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 198214010922 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198214010923 active site turn [active] 198214010924 phosphorylation site [posttranslational modification] 198214010925 Similar to Escherichia coli K12 probable 6-phospho-beta-glucosidase gi: 1790115 (213 aa). BLAST with identity of 98% in 213 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214010926 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198214010927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214010928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198214010929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214010930 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 198214010931 Na binding site [ion binding]; other site 198214010932 Similar to Escherichia coli K12 sulfatase gi: 1790112 (498 aa). BLAST with identity of 97% in 489 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214010933 Predicted membrane protein [Function unknown]; Region: COG2149 198214010934 Domain of unknown function (DUF202); Region: DUF202; pfam02656 198214010935 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 198214010936 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 198214010937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010938 putative substrate translocation pore; other site 198214010939 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 198214010940 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198214010941 dimer interface [polypeptide binding]; other site 198214010942 PYR/PP interface [polypeptide binding]; other site 198214010943 TPP binding site [chemical binding]; other site 198214010944 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198214010945 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198214010946 TPP-binding site [chemical binding]; other site 198214010947 dimer interface [polypeptide binding]; other site 198214010948 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 198214010949 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 198214010950 putative valine binding site [chemical binding]; other site 198214010951 dimer interface [polypeptide binding]; other site 198214010952 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 198214010953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214010954 active site 198214010955 phosphorylation site [posttranslational modification] 198214010956 intermolecular recognition site; other site 198214010957 dimerization interface [polypeptide binding]; other site 198214010958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214010959 DNA binding residues [nucleotide binding] 198214010960 dimerization interface [polypeptide binding]; other site 198214010961 sensory histidine kinase UhpB; Provisional; Region: PRK11644 198214010962 MASE1; Region: MASE1; pfam05231 198214010963 Histidine kinase; Region: HisKA_3; pfam07730 198214010964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214010965 ATP binding site [chemical binding]; other site 198214010966 Mg2+ binding site [ion binding]; other site 198214010967 G-X-G motif; other site 198214010968 regulatory protein UhpC; Provisional; Region: PRK11663 198214010969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010970 putative substrate translocation pore; other site 198214010971 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 198214010972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010973 putative substrate translocation pore; other site 198214010974 cryptic adenine deaminase; Provisional; Region: PRK10027 198214010975 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198214010976 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 198214010977 active site 198214010978 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198214010979 Sulfate transporter family; Region: Sulfate_transp; cl19250 198214010980 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 198214010981 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 198214010982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214010983 putative substrate translocation pore; other site 198214010984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010985 Transposase; Region: HTH_Tnp_1; pfam01527 198214010986 putative transposase OrfB; Reviewed; Region: PHA02517 198214010987 HTH-like domain; Region: HTH_21; pfam13276 198214010988 Integrase core domain; Region: rve; pfam00665 198214010989 Integrase core domain; Region: rve_3; pfam13683 198214010990 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 198214010991 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214010992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214010993 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214010994 HTH-like domain; Region: HTH_21; pfam13276 198214010995 Integrase core domain; Region: rve; pfam00665 198214010996 Integrase core domain; Region: rve_3; pfam13683 198214010997 fimbrial protein; Provisional; Region: lpfA; PRK15289 198214010998 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214010999 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214011000 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214011001 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 198214011002 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 198214011003 glutaminase active site [active] 198214011004 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 198214011005 dimer interface [polypeptide binding]; other site 198214011006 active site 198214011007 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 198214011008 dimer interface [polypeptide binding]; other site 198214011009 active site 198214011010 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 198214011011 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 198214011012 Substrate binding site; other site 198214011013 Mg++ binding site; other site 198214011014 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 198214011015 active site 198214011016 substrate binding site [chemical binding]; other site 198214011017 CoA binding site [chemical binding]; other site 198214011018 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 198214011019 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 198214011020 gamma subunit interface [polypeptide binding]; other site 198214011021 epsilon subunit interface [polypeptide binding]; other site 198214011022 LBP interface [polypeptide binding]; other site 198214011023 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 198214011024 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198214011025 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 198214011026 alpha subunit interaction interface [polypeptide binding]; other site 198214011027 Walker A motif; other site 198214011028 ATP binding site [chemical binding]; other site 198214011029 Walker B motif; other site 198214011030 inhibitor binding site; inhibition site 198214011031 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198214011032 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 198214011033 core domain interface [polypeptide binding]; other site 198214011034 delta subunit interface [polypeptide binding]; other site 198214011035 epsilon subunit interface [polypeptide binding]; other site 198214011036 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 198214011037 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198214011038 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 198214011039 beta subunit interaction interface [polypeptide binding]; other site 198214011040 Walker A motif; other site 198214011041 ATP binding site [chemical binding]; other site 198214011042 Walker B motif; other site 198214011043 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198214011044 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 198214011045 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 198214011046 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 198214011047 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 198214011048 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 198214011049 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 198214011050 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 198214011051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214011052 S-adenosylmethionine binding site [chemical binding]; other site 198214011053 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 198214011054 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 198214011055 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 198214011056 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 198214011057 FMN-binding protein MioC; Provisional; Region: PRK09004 198214011058 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 198214011059 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198214011060 putative DNA binding site [nucleotide binding]; other site 198214011061 putative Zn2+ binding site [ion binding]; other site 198214011062 AsnC family; Region: AsnC_trans_reg; pfam01037 198214011063 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 198214011064 dimer interface [polypeptide binding]; other site 198214011065 active site 198214011066 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 198214011067 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 198214011068 metal ion-dependent adhesion site (MIDAS); other site 198214011069 regulatory ATPase RavA; Provisional; Region: PRK13531 198214011070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214011071 Walker A motif; other site 198214011072 ATP binding site [chemical binding]; other site 198214011073 Walker B motif; other site 198214011074 arginine finger; other site 198214011075 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 198214011076 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214011077 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214011078 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214011079 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 198214011080 D-ribose pyranase; Provisional; Region: PRK11797 198214011081 Similar to Escherichia coli K12 ATP-binding component of D-ribose high-affinity transport system gi: 1790190 (502 aa). BLAST with identity of 98% in 761 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214011082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214011083 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214011084 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214011085 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214011086 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214011087 TM-ABC transporter signature motif; other site 198214011088 Similar to Escherichia coli K12 D-ribose periplasmic binding protein gi: 1790192 (297 aa). BLAST with identity of 98% in 297 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214011089 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 198214011090 substrate binding site [chemical binding]; other site 198214011091 dimer interface [polypeptide binding]; other site 198214011092 ATP binding site [chemical binding]; other site 198214011093 transcriptional repressor RbsR; Provisional; Region: PRK10423 198214011094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214011095 DNA binding site [nucleotide binding] 198214011096 domain linker motif; other site 198214011097 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 198214011098 dimerization interface [polypeptide binding]; other site 198214011099 ligand binding site [chemical binding]; other site 198214011100 putative transporter; Provisional; Region: PRK10504 198214011101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214011102 putative substrate translocation pore; other site 198214011103 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198214011104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214011105 DNA-binding site [nucleotide binding]; DNA binding site 198214011106 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214011107 transcriptional regulator HdfR; Provisional; Region: PRK03601 198214011108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214011109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198214011110 dimerization interface [polypeptide binding]; other site 198214011111 hypothetical protein; Provisional; Region: PRK11027 198214011112 Similar to Escherichia coli K12 2-component regulator gi: 1790201 (517 aa). BLAST with identity of 97% in 503 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214011113 ilvG operon leader peptide; Provisional; Region: PRK10424 198214011114 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 198214011115 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198214011116 PYR/PP interface [polypeptide binding]; other site 198214011117 dimer interface [polypeptide binding]; other site 198214011118 TPP binding site [chemical binding]; other site 198214011119 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198214011120 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198214011121 TPP-binding site [chemical binding]; other site 198214011122 dimer interface [polypeptide binding]; other site 198214011123 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 198214011124 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 198214011125 homodimer interface [polypeptide binding]; other site 198214011126 substrate-cofactor binding pocket; other site 198214011127 catalytic residue [active] 198214011128 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 198214011129 threonine dehydratase; Reviewed; Region: PRK09224 198214011130 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198214011131 tetramer interface [polypeptide binding]; other site 198214011132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214011133 catalytic residue [active] 198214011134 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 198214011135 putative Ile/Val binding site [chemical binding]; other site 198214011136 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 198214011137 putative Ile/Val binding site [chemical binding]; other site 198214011138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214011139 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 198214011140 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 198214011141 putative dimerization interface [polypeptide binding]; other site 198214011142 ketol-acid reductoisomerase; Validated; Region: PRK05225 198214011143 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 198214011144 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 198214011145 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 198214011146 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 198214011147 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 198214011148 Part of AAA domain; Region: AAA_19; pfam13245 198214011149 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198214011150 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 198214011151 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 198214011152 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 198214011153 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198214011154 ATP binding site [chemical binding]; other site 198214011155 Mg++ binding site [ion binding]; other site 198214011156 motif III; other site 198214011157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214011158 nucleotide binding region [chemical binding]; other site 198214011159 ATP-binding site [chemical binding]; other site 198214011160 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198214011161 catalytic residues [active] 198214011162 putative rho operon leader peptide; Provisional; Region: PRK09979 198214011163 transcription termination factor Rho; Provisional; Region: rho; PRK09376 198214011164 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 198214011165 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 198214011166 RNA binding site [nucleotide binding]; other site 198214011167 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 198214011168 multimer interface [polypeptide binding]; other site 198214011169 Walker A motif; other site 198214011170 ATP binding site [chemical binding]; other site 198214011171 Walker B motif; other site 198214011172 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 198214011173 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 198214011174 Mg++ binding site [ion binding]; other site 198214011175 putative catalytic motif [active] 198214011176 substrate binding site [chemical binding]; other site 198214011177 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 198214011178 Chain length determinant protein; Region: Wzz; pfam02706 198214011179 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198214011180 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 198214011181 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 198214011182 active site 198214011183 homodimer interface [polypeptide binding]; other site 198214011184 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 198214011185 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 198214011186 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 198214011187 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 198214011188 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 198214011189 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 198214011190 NAD binding site [chemical binding]; other site 198214011191 substrate binding site [chemical binding]; other site 198214011192 homodimer interface [polypeptide binding]; other site 198214011193 active site 198214011194 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 198214011195 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 198214011196 substrate binding site; other site 198214011197 tetramer interface; other site 198214011198 TDP-D-fucosamine acetyltransferase; Region: wecD_rffC; TIGR02382 198214011199 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 198214011200 inhibitor-cofactor binding pocket; inhibition site 198214011201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214011202 catalytic residue [active] 198214011203 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198214011204 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 198214011205 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 198214011206 putative common antigen polymerase; Provisional; Region: PRK02975 198214011207 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 198214011208 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 198214011209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214011210 FeS/SAM binding site; other site 198214011211 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 198214011212 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214011213 HTH-like domain; Region: HTH_21; pfam13276 198214011214 Integrase core domain; Region: rve; pfam00665 198214011215 Integrase core domain; Region: rve_3; pfam13683 198214011216 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214011217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214011218 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 198214011219 HemY protein N-terminus; Region: HemY_N; pfam07219 198214011220 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 198214011221 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 198214011222 active site 198214011223 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 198214011224 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 198214011225 domain interfaces; other site 198214011226 active site 198214011227 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 198214011228 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 198214011229 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 198214011230 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 198214011231 putative iron binding site [ion binding]; other site 198214011232 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790240 (162 aa). BLAST with identity of 97% in 1275 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214011233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214011234 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214011235 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214011236 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214011237 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 198214011238 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 198214011239 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198214011240 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198214011241 hypothetical protein; Provisional; Region: PRK10963 198214011242 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 198214011243 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 198214011244 active site 198214011245 Int/Topo IB signature motif; other site 198214011246 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 198214011247 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 198214011248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214011249 motif II; other site 198214011250 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 198214011251 Part of AAA domain; Region: AAA_19; pfam13245 198214011252 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 198214011253 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790248 (162 aa). BLAST with identity of 99% in 641 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214011254 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214011255 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214011256 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214011257 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 198214011258 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 198214011259 Cl binding site [ion binding]; other site 198214011260 oligomer interface [polypeptide binding]; other site 198214011261 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 198214011262 hypothetical protein; Provisional; Region: PRK11371 198214011263 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 198214011264 Multidrug resistance efflux transporter; Region: EmrE; cl19304 198214011265 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198214011266 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 198214011267 CoenzymeA binding site [chemical binding]; other site 198214011268 subunit interaction site [polypeptide binding]; other site 198214011269 PHB binding site; other site 198214011270 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 198214011271 dimerization interface [polypeptide binding]; other site 198214011272 substrate binding site [chemical binding]; other site 198214011273 active site 198214011274 calcium binding site [ion binding]; other site 198214011275 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 198214011276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214011277 ATP binding site [chemical binding]; other site 198214011278 putative Mg++ binding site [ion binding]; other site 198214011279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198214011280 nucleotide binding region [chemical binding]; other site 198214011281 ATP-binding site [chemical binding]; other site 198214011282 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 198214011283 Helicase and RNase D C-terminal; Region: HRDC; smart00341 198214011284 threonine efflux system; Provisional; Region: PRK10229 198214011285 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 198214011286 lysophospholipase L2; Provisional; Region: PRK10749 198214011287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198214011288 putative hydrolase; Provisional; Region: PRK10976 198214011289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214011290 active site 198214011291 motif I; other site 198214011292 motif II; other site 198214011293 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 198214011294 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198214011295 EamA-like transporter family; Region: EamA; pfam00892 198214011296 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 198214011297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214011298 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 198214011299 putative dimerization interface [polypeptide binding]; other site 198214011300 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 198214011301 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 198214011302 THF binding site; other site 198214011303 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 198214011304 substrate binding site [chemical binding]; other site 198214011305 THF binding site; other site 198214011306 zinc-binding site [ion binding]; other site 198214011307 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 198214011308 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 198214011309 uridine phosphorylase; Provisional; Region: PRK11178 198214011310 DNA recombination protein RmuC; Provisional; Region: PRK10361 198214011311 RmuC family; Region: RmuC; pfam02646 198214011312 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 198214011313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214011314 S-adenosylmethionine binding site [chemical binding]; other site 198214011315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 198214011316 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 198214011317 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 198214011318 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 198214011319 sec-independent translocase; Provisional; Region: PRK01770 198214011320 sec-independent translocase; Provisional; Region: tatB; PRK00404 198214011321 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 198214011322 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198214011323 active site 198214011324 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 198214011325 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 198214011326 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 198214011327 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 198214011328 FMN reductase; Validated; Region: fre; PRK08051 198214011329 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 198214011330 FAD binding pocket [chemical binding]; other site 198214011331 FAD binding motif [chemical binding]; other site 198214011332 phosphate binding motif [ion binding]; other site 198214011333 beta-alpha-beta structure motif; other site 198214011334 NAD binding pocket [chemical binding]; other site 198214011335 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 198214011336 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198214011337 dimer interface [polypeptide binding]; other site 198214011338 active site 198214011339 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 198214011340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198214011341 substrate binding site [chemical binding]; other site 198214011342 oxyanion hole (OAH) forming residues; other site 198214011343 trimer interface [polypeptide binding]; other site 198214011344 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198214011345 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198214011346 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198214011347 proline dipeptidase; Provisional; Region: PRK13607 198214011348 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 198214011349 active site 198214011350 hypothetical protein; Provisional; Region: PRK11568 198214011351 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 198214011352 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 198214011353 potassium transporter; Provisional; Region: PRK10750 198214011354 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 198214011355 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 198214011356 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 198214011357 Walker A motif; other site 198214011358 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 198214011359 GTP binding site; other site 198214011360 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 198214011361 serine/threonine protein kinase; Provisional; Region: PRK11768 198214011362 Phosphotransferase enzyme family; Region: APH; pfam01636 198214011363 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 198214011364 catalytic residues [active] 198214011365 hinge region; other site 198214011366 alpha helical domain; other site 198214011367 hypothetical protein; Provisional; Region: PRK11367 198214011368 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 198214011369 putative acyl-acceptor binding pocket; other site 198214011370 DNA polymerase I; Provisional; Region: PRK05755 198214011371 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198214011372 active site 198214011373 metal binding site 1 [ion binding]; metal-binding site 198214011374 putative 5' ssDNA interaction site; other site 198214011375 metal binding site 3; metal-binding site 198214011376 metal binding site 2 [ion binding]; metal-binding site 198214011377 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198214011378 putative DNA binding site [nucleotide binding]; other site 198214011379 putative metal binding site [ion binding]; other site 198214011380 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 198214011381 active site 198214011382 catalytic site [active] 198214011383 substrate binding site [chemical binding]; other site 198214011384 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 198214011385 active site 198214011386 DNA binding site [nucleotide binding] 198214011387 catalytic site [active] 198214011388 Predicted GTPase [General function prediction only]; Region: COG0218 198214011389 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 198214011390 G1 box; other site 198214011391 GTP/Mg2+ binding site [chemical binding]; other site 198214011392 Switch I region; other site 198214011393 G2 box; other site 198214011394 G3 box; other site 198214011395 Switch II region; other site 198214011396 G4 box; other site 198214011397 G5 box; other site 198214011398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 198214011399 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 198214011400 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214011401 FeS/SAM binding site; other site 198214011402 HemN C-terminal domain; Region: HemN_C; pfam06969 198214011403 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 198214011404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214011405 active site 198214011406 phosphorylation site [posttranslational modification] 198214011407 intermolecular recognition site; other site 198214011408 dimerization interface [polypeptide binding]; other site 198214011409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214011410 Walker A motif; other site 198214011411 ATP binding site [chemical binding]; other site 198214011412 Walker B motif; other site 198214011413 arginine finger; other site 198214011414 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198214011415 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 198214011416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198214011417 putative active site [active] 198214011418 heme pocket [chemical binding]; other site 198214011419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214011420 dimer interface [polypeptide binding]; other site 198214011421 phosphorylation site [posttranslational modification] 198214011422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214011423 ATP binding site [chemical binding]; other site 198214011424 Mg2+ binding site [ion binding]; other site 198214011425 G-X-G motif; other site 198214011426 glutamine synthetase; Provisional; Region: glnA; PRK09469 198214011427 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 198214011428 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 198214011429 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 198214011430 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 198214011431 G1 box; other site 198214011432 putative GEF interaction site [polypeptide binding]; other site 198214011433 GTP/Mg2+ binding site [chemical binding]; other site 198214011434 Switch I region; other site 198214011435 G2 box; other site 198214011436 G3 box; other site 198214011437 Switch II region; other site 198214011438 G4 box; other site 198214011439 G5 box; other site 198214011440 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 198214011441 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 198214011442 transcriptional regulator protein; Region: phnR; TIGR03337 198214011443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214011444 DNA-binding site [nucleotide binding]; DNA binding site 198214011445 UTRA domain; Region: UTRA; pfam07702 198214011446 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 198214011447 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198214011448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214011449 putative substrate translocation pore; other site 198214011450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214011451 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214011452 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214011453 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214011454 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 198214011455 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 198214011456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214011457 putative substrate translocation pore; other site 198214011458 alpha-glucosidase; Provisional; Region: PRK10426 198214011459 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 198214011460 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 198214011461 putative active site [active] 198214011462 putative catalytic site [active] 198214011463 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 198214011464 active site 198214011465 catalytic residues [active] 198214011466 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 198214011467 dimerization interface [polypeptide binding]; other site 198214011468 putative active cleft [active] 198214011469 Class I aldolases; Region: Aldolase_Class_I; cl17187 198214011470 catalytic residue [active] 198214011471 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 198214011472 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 198214011473 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 198214011474 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 198214011475 substrate binding site [chemical binding]; other site 198214011476 ATP binding site [chemical binding]; other site 198214011477 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198214011478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198214011479 putative DNA binding site [nucleotide binding]; other site 198214011480 putative Zn2+ binding site [ion binding]; other site 198214011481 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214011482 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 198214011483 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 198214011484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214011485 motif II; other site 198214011486 hypothetical protein; Reviewed; Region: PRK01637 198214011487 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 198214011488 putative active site [active] 198214011489 dimerization interface [polypeptide binding]; other site 198214011490 putative tRNAtyr binding site [nucleotide binding]; other site 198214011491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214011492 Coenzyme A binding pocket [chemical binding]; other site 198214011493 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 198214011494 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214011495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214011496 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214011497 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214011498 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 198214011499 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 198214011500 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 198214011501 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 198214011502 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214011503 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 198214011504 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 198214011505 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198214011506 [4Fe-4S] binding site [ion binding]; other site 198214011507 molybdopterin cofactor binding site; other site 198214011508 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 198214011509 molybdopterin cofactor binding site; other site 198214011510 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 198214011511 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214011512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214011513 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214011514 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214011515 Similar to Escherichia coli K12 frv operon regulatory protein gi: 1790331 (583 aa). BLAST with identity of 99% in 209 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214011516 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 198214011517 oligomer interface [polypeptide binding]; other site 198214011518 active site 198214011519 metal binding site [ion binding]; metal-binding site 198214011520 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 198214011521 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198214011522 active site 198214011523 P-loop; other site 198214011524 phosphorylation site [posttranslational modification] 198214011525 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 198214011526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214011527 active site 198214011528 phosphorylation site [posttranslational modification] 198214011529 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 198214011530 L-rhamnose isomerase; Provisional; Region: PRK01076 198214011531 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 198214011532 N- and C-terminal domain interface [polypeptide binding]; other site 198214011533 active site 198214011534 putative catalytic site [active] 198214011535 metal binding site [ion binding]; metal-binding site 198214011536 ATP binding site [chemical binding]; other site 198214011537 rhamnulokinase; Provisional; Region: rhaB; PRK10640 198214011538 carbohydrate binding site [chemical binding]; other site 198214011539 transcriptional activator RhaS; Provisional; Region: PRK13503 198214011540 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198214011541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011543 transcriptional activator RhaR; Provisional; Region: PRK13500 198214011544 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198214011545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011547 superoxide dismutase; Provisional; Region: PRK10925 198214011548 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198214011549 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198214011550 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 198214011551 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214011552 HTH-like domain; Region: HTH_21; pfam13276 198214011553 Integrase core domain; Region: rve; pfam00665 198214011554 Integrase core domain; Region: rve_3; pfam13683 198214011555 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214011556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214011557 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 198214011558 MOSC domain; Region: MOSC; pfam03473 198214011559 3-alpha domain; Region: 3-alpha; pfam03475 198214011560 two-component sensor protein; Provisional; Region: cpxA; PRK09470 198214011561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214011562 dimerization interface [polypeptide binding]; other site 198214011563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214011564 dimer interface [polypeptide binding]; other site 198214011565 phosphorylation site [posttranslational modification] 198214011566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214011567 ATP binding site [chemical binding]; other site 198214011568 Mg2+ binding site [ion binding]; other site 198214011569 G-X-G motif; other site 198214011570 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 198214011571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214011572 active site 198214011573 intermolecular recognition site; other site 198214011574 dimerization interface [polypeptide binding]; other site 198214011575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214011576 DNA binding site [nucleotide binding] 198214011577 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 198214011578 dimer interface [polypeptide binding]; other site 198214011579 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 198214011580 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 198214011581 active site 198214011582 ADP/pyrophosphate binding site [chemical binding]; other site 198214011583 dimerization interface [polypeptide binding]; other site 198214011584 allosteric effector site; other site 198214011585 fructose-1,6-bisphosphate binding site; other site 198214011586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214011587 substrate binding pocket [chemical binding]; other site 198214011588 membrane-bound complex binding site; other site 198214011589 hinge residues; other site 198214011590 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 198214011591 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 198214011592 substrate binding site [chemical binding]; other site 198214011593 dimer interface [polypeptide binding]; other site 198214011594 catalytic triad [active] 198214011595 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 198214011596 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790355 (147 aa). BLAST with identity of 99% in 147 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214011597 hypothetical protein; Provisional; Region: PRK09981 198214011598 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198214011599 Ligand Binding Site [chemical binding]; other site 198214011600 ferredoxin-NADP reductase; Provisional; Region: PRK10926 198214011601 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 198214011602 FAD binding pocket [chemical binding]; other site 198214011603 FAD binding motif [chemical binding]; other site 198214011604 phosphate binding motif [ion binding]; other site 198214011605 beta-alpha-beta structure motif; other site 198214011606 NAD binding pocket [chemical binding]; other site 198214011607 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 198214011608 putative active site [active] 198214011609 glycerol kinase; Region: glycerol_kin; TIGR01311 198214011610 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 198214011611 homotetramer interface [polypeptide binding]; other site 198214011612 N- and C-terminal domain interface [polypeptide binding]; other site 198214011613 active site 198214011614 glycerol binding site [chemical binding]; other site 198214011615 homodimer interface [polypeptide binding]; other site 198214011616 FBP binding site [chemical binding]; other site 198214011617 MgATP binding site [chemical binding]; other site 198214011618 protein IIAGlc interface [polypeptide binding]; other site 198214011619 septal ring assembly protein ZapB; Provisional; Region: PRK15422 198214011620 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 198214011621 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 198214011622 putative active site [active] 198214011623 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 198214011624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214011625 Walker A motif; other site 198214011626 ATP binding site [chemical binding]; other site 198214011627 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 198214011628 Walker B motif; other site 198214011629 arginine finger; other site 198214011630 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198214011631 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 198214011632 active site 198214011633 HslU subunit interaction site [polypeptide binding]; other site 198214011634 essential cell division protein FtsN; Provisional; Region: PRK10927 198214011635 Sporulation related domain; Region: SPOR; pfam05036 198214011636 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214011637 DNA binding site [nucleotide binding] 198214011638 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 198214011639 domain linker motif; other site 198214011640 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 198214011641 dimerization interface [polypeptide binding]; other site 198214011642 ligand binding site [chemical binding]; other site 198214011643 primosome assembly protein PriA; Validated; Region: PRK05580 198214011644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214011645 ATP binding site [chemical binding]; other site 198214011646 putative Mg++ binding site [ion binding]; other site 198214011647 helicase superfamily c-terminal domain; Region: HELICc; smart00490 198214011648 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 198214011649 hypothetical protein; Provisional; Region: PRK10030 198214011650 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 198214011651 dimerization interface [polypeptide binding]; other site 198214011652 DNA binding site [nucleotide binding] 198214011653 corepressor binding sites; other site 198214011654 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198214011655 homodimer interface [polypeptide binding]; other site 198214011656 substrate-cofactor binding pocket; other site 198214011657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214011658 catalytic residue [active] 198214011659 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 198214011660 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 198214011661 putative catalytic residues [active] 198214011662 putative nucleotide binding site [chemical binding]; other site 198214011663 putative aspartate binding site [chemical binding]; other site 198214011664 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 198214011665 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198214011666 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198214011667 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 198214011668 FAD binding site [chemical binding]; other site 198214011669 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 198214011670 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 198214011671 heme binding site [chemical binding]; other site 198214011672 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 198214011673 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198214011674 EamA-like transporter family; Region: EamA; pfam00892 198214011675 EamA-like transporter family; Region: EamA; pfam00892 198214011676 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790380 (206 aa). BLAST with identity of 95% in 202 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214011677 'Similar to Escherichia coli K12 glycerol dehydrogenase, (NAD) gi: 1790381 (381 aa). BLAST with identity of 97% in 380 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct.' 198214011678 Similar to Escherichia coli K12 PEP-protein phosphotransferase system enzyme I gi: 1790383 (712 aa). BLAST with identity of 97% in 711 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214011679 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 198214011680 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198214011681 active site 198214011682 P-loop; other site 198214011683 phosphorylation site [posttranslational modification] 198214011684 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 198214011685 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 198214011686 dimer interface [polypeptide binding]; other site 198214011687 active site 198214011688 glycine loop; other site 198214011689 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 198214011690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214011691 FeS/SAM binding site; other site 198214011692 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198214011693 active site 198214011694 P-loop; other site 198214011695 phosphorylation site [posttranslational modification] 198214011696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011697 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198214011698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011699 hypothetical protein; Provisional; Region: PRK10649 198214011700 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198214011701 Sulfatase; Region: Sulfatase; pfam00884 198214011702 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 198214011703 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 198214011704 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 198214011705 metal binding site [ion binding]; metal-binding site 198214011706 putative dimer interface [polypeptide binding]; other site 198214011707 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 198214011708 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 198214011709 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 198214011710 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 198214011711 nucleotide binding site [chemical binding]; other site 198214011712 N-acetyl-L-glutamate binding site [chemical binding]; other site 198214011713 argininosuccinate lyase; Provisional; Region: PRK04833 198214011714 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 198214011715 active sites [active] 198214011716 tetramer interface [polypeptide binding]; other site 198214011717 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214011718 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214011719 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214011720 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 198214011721 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 198214011722 putative active site pocket [active] 198214011723 putative metal binding site [ion binding]; other site 198214011724 Similar to Escherichia coli O157:H7 transport protein ref: NP_313343.1 (453 aa). BLAST with identity of 59% in 687 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214011725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214011726 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214011727 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214011728 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214011729 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 198214011730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214011731 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 198214011732 dimerization interface [polypeptide binding]; other site 198214011733 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 198214011734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198214011735 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 198214011736 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 198214011737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214011738 hypothetical protein; Provisional; Region: PRK11056 198214011739 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 198214011740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214011741 S-adenosylmethionine binding site [chemical binding]; other site 198214011742 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 198214011743 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198214011744 N-terminal plug; other site 198214011745 ligand-binding site [chemical binding]; other site 198214011746 glutamate racemase; Provisional; Region: PRK00865 198214011747 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 198214011748 FAD binding domain; Region: FAD_binding_4; pfam01565 198214011749 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 198214011750 Biotin operon repressor [Transcription]; Region: BirA; COG1654 198214011751 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 198214011752 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 198214011753 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 198214011754 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 198214011755 ATP-binding site [chemical binding]; other site 198214011756 CoA-binding site [chemical binding]; other site 198214011757 Mg2+-binding site [ion binding]; other site 198214011758 elongation factor Tu; Reviewed; Region: PRK00049 198214011759 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 198214011760 G1 box; other site 198214011761 GEF interaction site [polypeptide binding]; other site 198214011762 GTP/Mg2+ binding site [chemical binding]; other site 198214011763 Switch I region; other site 198214011764 G2 box; other site 198214011765 G3 box; other site 198214011766 Switch II region; other site 198214011767 G4 box; other site 198214011768 G5 box; other site 198214011769 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 198214011770 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 198214011771 Antibiotic Binding Site [chemical binding]; other site 198214011772 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 198214011773 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 198214011774 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 198214011775 putative homodimer interface [polypeptide binding]; other site 198214011776 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 198214011777 heterodimer interface [polypeptide binding]; other site 198214011778 homodimer interface [polypeptide binding]; other site 198214011779 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 198214011780 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 198214011781 23S rRNA interface [nucleotide binding]; other site 198214011782 L7/L12 interface [polypeptide binding]; other site 198214011783 putative thiostrepton binding site; other site 198214011784 L25 interface [polypeptide binding]; other site 198214011785 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 198214011786 mRNA/rRNA interface [nucleotide binding]; other site 198214011787 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 198214011788 23S rRNA interface [nucleotide binding]; other site 198214011789 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 198214011790 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 198214011791 core dimer interface [polypeptide binding]; other site 198214011792 peripheral dimer interface [polypeptide binding]; other site 198214011793 L10 interface [polypeptide binding]; other site 198214011794 L11 interface [polypeptide binding]; other site 198214011795 putative EF-Tu interaction site [polypeptide binding]; other site 198214011796 putative EF-G interaction site [polypeptide binding]; other site 198214011797 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 198214011798 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 198214011799 RPB12 interaction site [polypeptide binding]; other site 198214011800 RPB1 interaction site [polypeptide binding]; other site 198214011801 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 198214011802 RPB10 interaction site [polypeptide binding]; other site 198214011803 RPB11 interaction site [polypeptide binding]; other site 198214011804 RPB3 interaction site [polypeptide binding]; other site 198214011805 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 198214011806 beta and beta' interface [polypeptide binding]; other site 198214011807 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 198214011808 beta' and sigma factor interface [polypeptide binding]; other site 198214011809 Zn-binding [ion binding]; other site 198214011810 active site region [active] 198214011811 catalytic site [active] 198214011812 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 198214011813 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 198214011814 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 198214011815 G-loop; other site 198214011816 DNA binding site [nucleotide binding] 198214011817 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 198214011818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214011819 FeS/SAM binding site; other site 198214011820 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 198214011821 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 198214011822 ThiS interaction site; other site 198214011823 putative active site [active] 198214011824 tetramer interface [polypeptide binding]; other site 198214011825 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198214011826 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 198214011827 ATP binding site [chemical binding]; other site 198214011828 substrate interface [chemical binding]; other site 198214011829 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 198214011830 thiamine phosphate binding site [chemical binding]; other site 198214011831 active site 198214011832 pyrophosphate binding site [ion binding]; other site 198214011833 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 198214011834 ThiC-associated domain; Region: ThiC-associated; pfam13667 198214011835 ThiC family; Region: ThiC; pfam01964 198214011836 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 198214011837 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 198214011838 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 198214011839 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 198214011840 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 198214011841 putative NADH binding site [chemical binding]; other site 198214011842 putative active site [active] 198214011843 nudix motif; other site 198214011844 putative metal binding site [ion binding]; other site 198214011845 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 198214011846 substrate binding site [chemical binding]; other site 198214011847 active site 198214011848 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 198214011849 Active_site [active] 198214011850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 198214011851 histone-like DNA-binding protein HU; Region: HU; cd13831 198214011852 dimer interface [polypeptide binding]; other site 198214011853 DNA binding site [nucleotide binding] 198214011854 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 198214011855 zinc resistance protein; Provisional; Region: zraP; PRK11546 198214011856 dimer interface [polypeptide binding]; other site 198214011857 sensor protein ZraS; Provisional; Region: PRK10364 198214011858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214011859 dimer interface [polypeptide binding]; other site 198214011860 phosphorylation site [posttranslational modification] 198214011861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214011862 ATP binding site [chemical binding]; other site 198214011863 Mg2+ binding site [ion binding]; other site 198214011864 G-X-G motif; other site 198214011865 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 198214011866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214011867 active site 198214011868 phosphorylation site [posttranslational modification] 198214011869 intermolecular recognition site; other site 198214011870 dimerization interface [polypeptide binding]; other site 198214011871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214011872 Walker A motif; other site 198214011873 ATP binding site [chemical binding]; other site 198214011874 Walker B motif; other site 198214011875 arginine finger; other site 198214011876 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198214011877 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 198214011878 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 198214011879 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 198214011880 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 198214011881 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 198214011882 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 198214011883 purine monophosphate binding site [chemical binding]; other site 198214011884 dimer interface [polypeptide binding]; other site 198214011885 putative catalytic residues [active] 198214011886 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 198214011887 Similar to Escherichia coli K12 homoserine transsuccinylase gi: 1790443 (310 aa). BLAST with identity of 98% in 212 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214011888 Similar to Escherichia coli K12 malate synthase A gi: 1790444 (534 aa). BLAST with identity of 98% in 534 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214011889 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 198214011890 tetramer interface [polypeptide binding]; other site 198214011891 active site 198214011892 Mg2+/Mn2+ binding site [ion binding]; other site 198214011893 Similar to Escherichia coli K12 isocitrate dehydrogenase kinase/phosphatase gi: 1790446 (579 aa). BLAST with identity of 98% in 579 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214011894 Similar to Escherichia coli K12 regulator of acetyl CoA synthetase gi: 1790447 (729 aa). BLAST with identity of 98% in 728 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214011895 transcriptional repressor IclR; Provisional; Region: PRK11569 198214011896 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198214011897 Bacterial transcriptional regulator; Region: IclR; pfam01614 198214011898 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 198214011899 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 198214011900 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 198214011901 substrate binding pocket [chemical binding]; other site 198214011902 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 198214011903 B12 binding site [chemical binding]; other site 198214011904 cobalt ligand [ion binding]; other site 198214011905 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 198214011906 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 198214011907 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 198214011908 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 198214011909 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 198214011910 active site pocket [active] 198214011911 oxyanion hole [active] 198214011912 catalytic triad [active] 198214011913 active site nucleophile [active] 198214011914 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 198214011915 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 198214011916 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 198214011917 putative NAD(P) binding site [chemical binding]; other site 198214011918 catalytic Zn binding site [ion binding]; other site 198214011919 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 198214011920 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 198214011921 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 198214011922 active site 198214011923 phosphorylation site [posttranslational modification] 198214011924 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198214011925 active pocket/dimerization site; other site 198214011926 active site 198214011927 phosphorylation site [posttranslational modification] 198214011928 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 198214011929 classical (c) SDRs; Region: SDR_c; cd05233 198214011930 NAD(P) binding site [chemical binding]; other site 198214011931 active site 198214011932 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 198214011933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198214011934 putative DNA binding site [nucleotide binding]; other site 198214011935 putative Zn2+ binding site [ion binding]; other site 198214011936 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 198214011937 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 198214011938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198214011939 RNA binding surface [nucleotide binding]; other site 198214011940 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 198214011941 probable active site [active] 198214011942 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214011943 HTH-like domain; Region: HTH_21; pfam13276 198214011944 Integrase core domain; Region: rve; pfam00665 198214011945 Integrase core domain; Region: rve_3; pfam13683 198214011946 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214011947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214011948 sensory histidine kinase DcuS; Provisional; Region: PRK11086 198214011949 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 198214011950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198214011951 putative active site [active] 198214011952 heme pocket [chemical binding]; other site 198214011953 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 198214011954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214011955 ATP binding site [chemical binding]; other site 198214011956 Mg2+ binding site [ion binding]; other site 198214011957 G-X-G motif; other site 198214011958 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 198214011959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214011960 active site 198214011961 phosphorylation site [posttranslational modification] 198214011962 intermolecular recognition site; other site 198214011963 dimerization interface [polypeptide binding]; other site 198214011964 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 198214011965 fumarate hydratase FumB; Provisional; Region: PRK15391 198214011966 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 198214011967 Fumarase C-terminus; Region: Fumerase_C; pfam05683 198214011968 hypothetical protein; Provisional; Region: PRK09867 198214011969 melibiose:sodium symporter; Provisional; Region: PRK10429 198214011970 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 198214011971 alpha-galactosidase; Provisional; Region: PRK15076 198214011972 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 198214011973 NAD binding site [chemical binding]; other site 198214011974 sugar binding site [chemical binding]; other site 198214011975 divalent metal binding site [ion binding]; other site 198214011976 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 198214011977 dimer interface [polypeptide binding]; other site 198214011978 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 198214011979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011981 arginine decarboxylase; Provisional; Region: PRK15029 198214011982 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 198214011983 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198214011984 homodimer interface [polypeptide binding]; other site 198214011985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214011986 catalytic residue [active] 198214011987 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198214011988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198214011990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214011991 arginine:agmatin antiporter; Provisional; Region: PRK10644 198214011992 Spore germination protein; Region: Spore_permease; cl17796 198214011993 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214011994 putative metal dependent hydrolase; Provisional; Region: PRK11598 198214011995 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198214011996 Sulfatase; Region: Sulfatase; pfam00884 198214011997 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 198214011998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214011999 active site 198214012000 phosphorylation site [posttranslational modification] 198214012001 intermolecular recognition site; other site 198214012002 dimerization interface [polypeptide binding]; other site 198214012003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214012004 DNA binding site [nucleotide binding] 198214012005 sensor protein BasS/PmrB; Provisional; Region: PRK10755 198214012006 HAMP domain; Region: HAMP; pfam00672 198214012007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214012008 dimer interface [polypeptide binding]; other site 198214012009 phosphorylation site [posttranslational modification] 198214012010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214012011 ATP binding site [chemical binding]; other site 198214012012 Mg2+ binding site [ion binding]; other site 198214012013 G-X-G motif; other site 198214012014 proline/glycine betaine transporter; Provisional; Region: PRK10642 198214012015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214012016 putative substrate translocation pore; other site 198214012017 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 198214012018 YjcZ-like protein; Region: YjcZ; pfam13990 198214012019 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 198214012020 G1 box; other site 198214012021 GTP/Mg2+ binding site [chemical binding]; other site 198214012022 G2 box; other site 198214012023 Switch I region; other site 198214012024 G3 box; other site 198214012025 Switch II region; other site 198214012026 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 198214012027 G2 box; other site 198214012028 Switch I region; other site 198214012029 G3 box; other site 198214012030 Switch II region; other site 198214012031 G4 box; other site 198214012032 G5 box; other site 198214012033 hypothetical protein; Provisional; Region: PRK10220 198214012034 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 198214012035 PhnA protein; Region: PhnA; pfam03831 198214012036 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 198214012037 dimer interface [polypeptide binding]; other site 198214012038 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 198214012039 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 198214012040 Walker A/P-loop; other site 198214012041 ATP binding site [chemical binding]; other site 198214012042 Q-loop/lid; other site 198214012043 ABC transporter signature motif; other site 198214012044 Walker B; other site 198214012045 D-loop; other site 198214012046 H-loop/switch region; other site 198214012047 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 198214012048 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 198214012049 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012051 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012052 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012053 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790496 (529 aa). BLAST with identity of 98% in 526 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214012054 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 198214012055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214012056 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 198214012057 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 198214012058 DNA binding residues [nucleotide binding] 198214012059 dimer interface [polypeptide binding]; other site 198214012060 [2Fe-2S] cluster binding site [ion binding]; other site 198214012061 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198214012062 Sulfate transporter family; Region: Sulfate_transp; cl19250 198214012063 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 198214012064 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 198214012065 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198214012066 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 198214012067 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198214012068 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 198214012069 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198214012070 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 198214012071 Na binding site [ion binding]; other site 198214012072 Predicted membrane protein [Function unknown]; Region: COG3162 198214012073 Similar to Escherichia coli K12 acetyl-CoA synthetase gi: 1790505 (653 aa). BLAST with identity of 98% in 652 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214012074 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 198214012075 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 198214012076 Cytochrome c7; Region: Cytochrome_C7; cl19206 198214012077 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 198214012078 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 198214012079 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198214012080 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 198214012081 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 198214012082 heme lyase subunit NrfE; Provisional; Region: PRK10369 198214012083 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 198214012084 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 198214012085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198214012086 binding surface 198214012087 TPR motif; other site 198214012088 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 198214012089 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198214012090 Sel1-like repeats; Region: SEL1; smart00671 198214012091 Similar to Escherichia coli K12 selenopolypeptide subunit of formate dehydrogenase H gi: 3868721 (716 aa). BLAST with identity of 98% in 716 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214012092 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 198214012093 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 198214012094 Outer membrane efflux protein; Region: OEP; pfam02321 198214012095 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 198214012096 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198214012097 multidrug resistance protein MdtN; Provisional; Region: PRK10476 198214012098 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198214012099 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 198214012100 HlyD family secretion protein; Region: HlyD_3; pfam13437 198214012101 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012102 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 198214012103 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198214012104 dimer interface [polypeptide binding]; other site 198214012105 ssDNA binding site [nucleotide binding]; other site 198214012106 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198214012107 putative single-stranded DNA-binding protein; Region: PHA01740 198214012108 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 198214012109 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198214012110 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198214012111 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 198214012112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 198214012113 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 198214012114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214012115 active site 198214012116 motif I; other site 198214012117 motif II; other site 198214012118 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 198214012119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198214012120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198214012121 homodimer interface [polypeptide binding]; other site 198214012122 catalytic residue [active] 198214012123 alanine racemase; Reviewed; Region: alr; PRK00053 198214012124 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 198214012125 active site 198214012126 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198214012127 substrate binding site [chemical binding]; other site 198214012128 catalytic residues [active] 198214012129 dimer interface [polypeptide binding]; other site 198214012130 replicative DNA helicase; Provisional; Region: PRK08006 198214012131 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 198214012132 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 198214012133 Walker A motif; other site 198214012134 ATP binding site [chemical binding]; other site 198214012135 Walker B motif; other site 198214012136 DNA binding loops [nucleotide binding] 198214012137 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 198214012138 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 198214012139 NADP binding site [chemical binding]; other site 198214012140 dimer interface [polypeptide binding]; other site 198214012141 phage shock protein G; Reviewed; Region: pspG; PRK09459 198214012142 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198214012143 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 198214012144 FMN binding site [chemical binding]; other site 198214012145 active site 198214012146 catalytic residues [active] 198214012147 substrate binding site [chemical binding]; other site 198214012148 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 198214012149 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198214012150 metal binding site 2 [ion binding]; metal-binding site 198214012151 putative DNA binding helix; other site 198214012152 metal binding site 1 [ion binding]; metal-binding site 198214012153 dimer interface [polypeptide binding]; other site 198214012154 structural Zn2+ binding site [ion binding]; other site 198214012155 hypothetical protein; Provisional; Region: PRK10428 198214012156 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 198214012157 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 198214012158 LexA repressor; Validated; Region: PRK00215 198214012159 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 198214012160 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 198214012161 Catalytic site [active] 198214012162 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 198214012163 putative active site [active] 198214012164 trimer interface [polypeptide binding]; other site 198214012165 putative active site [active] 198214012166 Zn binding site [ion binding]; other site 198214012167 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 198214012168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 198214012169 putative acyl-acceptor binding pocket; other site 198214012170 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 198214012171 putative active site [active] 198214012172 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 198214012173 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790471 (443 aa). BLAST with identity of 98% in 441 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214012174 maltose regulon periplasmic protein; Provisional; Region: PRK10564 198214012175 maltoporin; Provisional; Region: lamB; PRK09360 198214012176 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 198214012177 trimer interface; other site 198214012178 sugar binding site [chemical binding]; other site 198214012179 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 198214012180 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198214012181 Walker A/P-loop; other site 198214012182 ATP binding site [chemical binding]; other site 198214012183 Q-loop/lid; other site 198214012184 ABC transporter signature motif; other site 198214012185 Walker B; other site 198214012186 D-loop; other site 198214012187 H-loop/switch region; other site 198214012188 TOBE domain; Region: TOBE_2; pfam08402 198214012189 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 198214012190 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 198214012191 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 198214012192 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 198214012193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214012194 dimer interface [polypeptide binding]; other site 198214012195 conserved gate region; other site 198214012196 putative PBP binding loops; other site 198214012197 ABC-ATPase subunit interface; other site 198214012198 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198214012199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198214012200 dimer interface [polypeptide binding]; other site 198214012201 conserved gate region; other site 198214012202 putative PBP binding loops; other site 198214012203 ABC-ATPase subunit interface; other site 198214012204 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 198214012205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214012206 putative substrate translocation pore; other site 198214012207 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 198214012208 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 198214012209 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 198214012210 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 198214012211 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 198214012212 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 198214012213 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 198214012214 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 198214012215 active site 198214012216 dimer interface [polypeptide binding]; other site 198214012217 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 198214012218 dimer interface [polypeptide binding]; other site 198214012219 active site 198214012220 aspartate kinase III; Validated; Region: PRK09084 198214012221 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 198214012222 nucleotide binding site [chemical binding]; other site 198214012223 putative catalytic residues [active] 198214012224 aspartate binding site [chemical binding]; other site 198214012225 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 198214012226 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 198214012227 dimer interface [polypeptide binding]; other site 198214012228 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214012229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214012230 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214012231 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214012232 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214012233 Homeodomain-like domain; Region: HTH_23; pfam13384 198214012234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214012235 Transposase; Region: HTH_Tnp_1; pfam01527 198214012236 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214012237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214012238 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214012239 HTH-like domain; Region: HTH_21; pfam13276 198214012240 Integrase core domain; Region: rve; pfam00665 198214012241 Integrase core domain; Region: rve_3; pfam13683 198214012242 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 198214012243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 198214012244 Nucleoside recognition; Region: Gate; pfam07670 198214012245 hypothetical protein; Provisional; Region: PRK10519 198214012246 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 198214012247 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 198214012248 dimer interface [polypeptide binding]; other site 198214012249 active site 198214012250 cell density-dependent motility repressor; Provisional; Region: PRK10082 198214012251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198214012252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198214012253 dimerization interface [polypeptide binding]; other site 198214012254 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 198214012255 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012257 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012258 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012259 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 198214012260 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 198214012261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198214012262 DNA-binding site [nucleotide binding]; DNA binding site 198214012263 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214012264 D-mannonate oxidoreductase; Provisional; Region: PRK15037 198214012265 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198214012266 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198214012267 mannonate dehydratase; Region: uxuA; TIGR00695 198214012268 mannonate dehydratase; Provisional; Region: PRK03906 198214012269 fructuronate transporter; Provisional; Region: PRK10034 198214012270 GntP family permease; Region: GntP_permease; pfam02447 198214012271 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 198214012272 mannosyl binding site [chemical binding]; other site 198214012273 Fimbrial protein; Region: Fimbrial; pfam00419 198214012274 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198214012275 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198214012276 'Similar to Escherichia coli K12 outer membrane protein; export and assembly of type 1 fimbriae, interrupted gi: 1790772 (879 aa). BLAST with identity of 98% in 1137 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct.' 198214012277 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012279 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012280 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012281 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 198214012282 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 198214012283 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 198214012284 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 198214012285 Fimbrial protein; Region: Fimbrial; cl01416 198214012286 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 198214012287 Int/Topo IB signature motif; other site 198214012288 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198214012289 active site 198214012290 Int/Topo IB signature motif; other site 198214012291 DNA binding site [nucleotide binding] 198214012292 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 198214012293 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 198214012294 Kelch motif; Region: Kelch_1; pfam01344 198214012295 Domain of unknown function (DUF303); Region: DUF303; pfam03629 198214012296 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012298 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012299 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012300 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214012301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214012302 Transposase; Region: HTH_Tnp_1; pfam01527 198214012303 putative transposase OrfB; Reviewed; Region: PHA02517 198214012304 HTH-like domain; Region: HTH_21; pfam13276 198214012305 Integrase core domain; Region: rve; pfam00665 198214012306 Integrase core domain; Region: rve_2; pfam13333 198214012307 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790648 (265 aa). BLAST with identity of 95% in 76 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214012308 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214012310 Transposase; Region: HTH_Tnp_1; cl17663 198214012311 putative transposase OrfB; Reviewed; Region: PHA02517 198214012312 HTH-like domain; Region: HTH_21; pfam13276 198214012313 Integrase core domain; Region: rve; pfam00665 198214012314 Integrase core domain; Region: rve_3; pfam13683 198214012315 integrase; Provisional; Region: PRK09692 198214012316 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198214012317 active site 198214012318 Int/Topo IB signature motif; other site 198214012319 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 198214012320 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 198214012321 putative NAD(P) binding site [chemical binding]; other site 198214012322 putative substrate binding site [chemical binding]; other site 198214012323 catalytic Zn binding site [ion binding]; other site 198214012324 structural Zn binding site [ion binding]; other site 198214012325 dimer interface [polypeptide binding]; other site 198214012326 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 198214012327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214012328 Walker A motif; other site 198214012329 ATP binding site [chemical binding]; other site 198214012330 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 198214012331 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 198214012332 multifunctional aminopeptidase A; Provisional; Region: PRK00913 198214012333 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 198214012334 interface (dimer of trimers) [polypeptide binding]; other site 198214012335 Substrate-binding/catalytic site; other site 198214012336 Zn-binding sites [ion binding]; other site 198214012337 DNA polymerase III subunit chi; Validated; Region: PRK05728 198214012338 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 198214012339 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 198214012340 active site 198214012341 HIGH motif; other site 198214012342 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198214012343 KMSKS motif; other site 198214012344 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 198214012345 tRNA binding surface [nucleotide binding]; other site 198214012346 anticodon binding site; other site 198214012347 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 198214012348 Predicted membrane protein [Function unknown]; Region: COG4269 198214012349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198214012350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214012351 Coenzyme A binding pocket [chemical binding]; other site 198214012352 RNase E inhibitor protein; Provisional; Region: PRK11191 198214012353 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 198214012354 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198214012355 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198214012356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012357 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012358 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012359 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012360 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790702 (617 aa). BLAST with identity of 90% in 252 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214012361 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 198214012362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198214012363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214012364 oxidoreductase; Provisional; Region: PRK12742 198214012365 classical (c) SDRs; Region: SDR_c; cd05233 198214012366 NAD(P) binding site [chemical binding]; other site 198214012367 active site 198214012368 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 198214012369 homotrimer interaction site [polypeptide binding]; other site 198214012370 putative active site [active] 198214012371 pyrBI operon leader peptide; Provisional; Region: PRK10224 198214012372 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 198214012373 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198214012374 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198214012375 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 198214012376 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 198214012377 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 198214012378 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198214012379 homotrimer interaction site [polypeptide binding]; other site 198214012380 putative active site [active] 198214012381 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 198214012382 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 198214012383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198214012384 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 198214012385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214012386 motif II; other site 198214012387 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 198214012388 trehalose repressor; Provisional; Region: treR; PRK09492 198214012389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198214012390 DNA binding site [nucleotide binding] 198214012391 domain linker motif; other site 198214012392 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 198214012393 dimerization interface [polypeptide binding]; other site 198214012394 ligand binding site [chemical binding]; other site 198214012395 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 198214012396 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198214012397 active site turn [active] 198214012398 phosphorylation site [posttranslational modification] 198214012399 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198214012400 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 198214012401 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 198214012402 Ca binding site [ion binding]; other site 198214012403 active site 198214012404 catalytic site [active] 198214012405 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 198214012406 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 198214012407 ATP cone domain; Region: ATP-cone; pfam03477 198214012408 Class III ribonucleotide reductase; Region: RNR_III; cd01675 198214012409 effector binding site; other site 198214012410 active site 198214012411 Zn binding site [ion binding]; other site 198214012412 glycine loop; other site 198214012413 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 198214012414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214012415 FeS/SAM binding site; other site 198214012416 Cytochrome b562; Region: Cytochrom_B562; cl01546 198214012417 peptidase PmbA; Provisional; Region: PRK11040 198214012418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 198214012419 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 198214012420 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198214012421 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198214012422 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198214012423 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 198214012424 AMP binding site [chemical binding]; other site 198214012425 metal binding site [ion binding]; metal-binding site 198214012426 active site 198214012427 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214012428 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214012429 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214012430 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198214012431 TM-ABC transporter signature motif; other site 198214012432 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198214012433 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198214012434 Walker A/P-loop; other site 198214012435 ATP binding site [chemical binding]; other site 198214012436 Q-loop/lid; other site 198214012437 ABC transporter signature motif; other site 198214012438 Walker B; other site 198214012439 D-loop; other site 198214012440 H-loop/switch region; other site 198214012441 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198214012442 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 198214012443 dimer interface [polypeptide binding]; other site 198214012444 substrate binding site [chemical binding]; other site 198214012445 metal binding sites [ion binding]; metal-binding site 198214012446 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 198214012447 putative active site pocket [active] 198214012448 dimerization interface [polypeptide binding]; other site 198214012449 putative catalytic residue [active] 198214012450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 198214012451 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198214012452 Family of unknown function (DUF490); Region: DUF490; pfam04357 198214012453 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 198214012454 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198214012455 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198214012456 Surface antigen; Region: Bac_surface_Ag; pfam01103 198214012457 methionine sulfoxide reductase A; Provisional; Region: PRK00058 198214012458 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198214012459 Domain of unknown function DUF21; Region: DUF21; pfam01595 198214012460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198214012461 Transporter associated domain; Region: CorC_HlyC; smart01091 198214012462 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 198214012463 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 198214012464 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 198214012465 active site 198214012466 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 198214012467 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 198214012468 active site 198214012469 metal binding site [ion binding]; metal-binding site 198214012470 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198214012471 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 198214012472 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 198214012473 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 198214012474 NADP binding site [chemical binding]; other site 198214012475 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198214012476 EamA-like transporter family; Region: EamA; pfam00892 198214012477 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 198214012478 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 198214012479 Hemerythrin-like domain; Region: Hr-like; cd12108 198214012480 Fe binding site [ion binding]; other site 198214012481 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 198214012482 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214012483 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 198214012484 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 198214012485 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198214012486 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 198214012487 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 198214012488 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 198214012489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198214012490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198214012491 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 198214012492 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 198214012493 putative NAD(P) binding site [chemical binding]; other site 198214012494 active site 198214012495 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 198214012496 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198214012497 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012498 putative transposase OrfB; Reviewed; Region: PHA02517 198214012499 HTH-like domain; Region: HTH_21; pfam13276 198214012500 Integrase core domain; Region: rve; pfam00665 198214012501 Integrase core domain; Region: rve_3; pfam13683 198214012502 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 198214012503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012504 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012505 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012506 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012507 putative transcriptional regulator; Provisional; Region: PRK11640 198214012508 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 198214012509 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 198214012510 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 198214012511 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 198214012512 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 198214012513 DsbD alpha interface [polypeptide binding]; other site 198214012514 catalytic residues [active] 198214012515 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 198214012516 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 198214012517 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 198214012518 Aspartase; Region: Aspartase; cd01357 198214012519 active sites [active] 198214012520 tetramer interface [polypeptide binding]; other site 198214012521 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 198214012522 putative transporter; Provisional; Region: PRK11021 198214012523 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 198214012524 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 198214012525 oligomerisation interface [polypeptide binding]; other site 198214012526 mobile loop; other site 198214012527 roof hairpin; other site 198214012528 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 198214012529 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 198214012530 ring oligomerisation interface [polypeptide binding]; other site 198214012531 ATP/Mg binding site [chemical binding]; other site 198214012532 stacking interactions; other site 198214012533 hinge regions; other site 198214012534 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 198214012535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012536 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012537 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012538 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012539 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 198214012540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214012541 FeS/SAM binding site; other site 198214012542 elongation factor P; Validated; Region: PRK00529 198214012543 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 198214012544 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 198214012545 RNA binding site [nucleotide binding]; other site 198214012546 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 198214012547 RNA binding site [nucleotide binding]; other site 198214012548 entericidin A; Provisional; Region: PRK09810 198214012549 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 198214012550 multidrug efflux system protein; Provisional; Region: PRK11431 198214012551 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 198214012552 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 198214012553 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 198214012554 Iron-sulfur protein interface; other site 198214012555 proximal quinone binding site [chemical binding]; other site 198214012556 C-subunit interface; other site 198214012557 distal quinone binding site; other site 198214012558 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 198214012559 D-subunit interface [polypeptide binding]; other site 198214012560 Iron-sulfur protein interface; other site 198214012561 proximal quinone binding site [chemical binding]; other site 198214012562 distal quinone binding site [chemical binding]; other site 198214012563 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 198214012564 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 198214012565 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 198214012566 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 198214012567 L-aspartate oxidase; Provisional; Region: PRK06175 198214012568 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198214012569 poxB regulator PoxA; Provisional; Region: PRK09350 198214012570 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 198214012571 motif 1; other site 198214012572 dimer interface [polypeptide binding]; other site 198214012573 active site 198214012574 motif 2; other site 198214012575 motif 3; other site 198214012576 Similar to Escherichia coli K12 transport gi: 1790600 (515 aa). BLAST with identity of 97% in 758 aa. This CDS has been disrupted by insertion. The sequence has been checked and is believed to be correct. 198214012577 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012579 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012580 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012581 putative mechanosensitive channel protein; Provisional; Region: PRK10929 198214012582 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 198214012583 DNA-binding site [nucleotide binding]; DNA binding site 198214012584 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 198214012585 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 198214012586 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198214012587 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 198214012588 GTPase RsgA; Reviewed; Region: PRK12288 198214012589 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198214012590 RNA binding site [nucleotide binding]; other site 198214012591 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 198214012592 GTPase/Zn-binding domain interface [polypeptide binding]; other site 198214012593 GTP/Mg2+ binding site [chemical binding]; other site 198214012594 G4 box; other site 198214012595 G5 box; other site 198214012596 G1 box; other site 198214012597 Switch I region; other site 198214012598 G2 box; other site 198214012599 G3 box; other site 198214012600 Switch II region; other site 198214012601 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 198214012602 catalytic site [active] 198214012603 putative active site [active] 198214012604 putative substrate binding site [chemical binding]; other site 198214012605 dimer interface [polypeptide binding]; other site 198214012606 epoxyqueuosine reductase; Region: TIGR00276 198214012607 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 198214012608 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 198214012609 putative carbohydrate kinase; Provisional; Region: PRK10565 198214012610 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 198214012611 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 198214012612 putative substrate binding site [chemical binding]; other site 198214012613 putative ATP binding site [chemical binding]; other site 198214012614 ADP-binding protein; Provisional; Region: PRK10646 198214012615 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 198214012616 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 198214012617 AMIN domain; Region: AMIN; pfam11741 198214012618 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198214012619 active site 198214012620 metal binding site [ion binding]; metal-binding site 198214012621 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 198214012622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214012623 ATP binding site [chemical binding]; other site 198214012624 Mg2+ binding site [ion binding]; other site 198214012625 G-X-G motif; other site 198214012626 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 198214012627 ATP binding site [chemical binding]; other site 198214012628 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 198214012629 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 198214012630 bacterial Hfq-like; Region: Hfq; cd01716 198214012631 hexamer interface [polypeptide binding]; other site 198214012632 Sm1 motif; other site 198214012633 RNA binding site [nucleotide binding]; other site 198214012634 Sm2 motif; other site 198214012635 GTPase HflX; Provisional; Region: PRK11058 198214012636 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 198214012637 HflX GTPase family; Region: HflX; cd01878 198214012638 G1 box; other site 198214012639 GTP/Mg2+ binding site [chemical binding]; other site 198214012640 Switch I region; other site 198214012641 G2 box; other site 198214012642 G3 box; other site 198214012643 Switch II region; other site 198214012644 G4 box; other site 198214012645 G5 box; other site 198214012646 FtsH protease regulator HflK; Provisional; Region: PRK10930 198214012647 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 198214012648 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 198214012649 HflC protein; Region: hflC; TIGR01932 198214012650 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 198214012651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 198214012652 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 198214012653 GDP-binding site [chemical binding]; other site 198214012654 ACT binding site; other site 198214012655 IMP binding site; other site 198214012656 transcriptional repressor NsrR; Provisional; Region: PRK11014 198214012657 Rrf2 family protein; Region: rrf2_super; TIGR00738 198214012658 exoribonuclease R; Provisional; Region: PRK11642 198214012659 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 198214012660 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198214012661 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198214012662 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 198214012663 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 198214012664 RNA binding site [nucleotide binding]; other site 198214012665 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 198214012666 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 198214012667 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198214012668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012669 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012670 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012671 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012672 Predicted integral membrane protein [Function unknown]; Region: COG5463 198214012673 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 198214012674 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 198214012675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198214012676 FAD binding site [chemical binding]; other site 198214012677 substrate binding site [chemical binding]; other site 198214012678 catalytic residues [active] 198214012679 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012681 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012682 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012683 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198214012684 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 198214012685 esterase; Provisional; Region: PRK10566 198214012686 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 198214012687 transcriptional repressor UlaR; Provisional; Region: PRK13509 198214012688 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198214012689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198214012690 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 198214012691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 198214012692 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 198214012693 active site 198214012694 P-loop; other site 198214012695 phosphorylation site [posttranslational modification] 198214012696 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198214012697 active site 198214012698 phosphorylation site [posttranslational modification] 198214012699 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 198214012700 active site 198214012701 dimer interface [polypeptide binding]; other site 198214012702 magnesium binding site [ion binding]; other site 198214012703 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 198214012704 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 198214012705 AP (apurinic/apyrimidinic) site pocket; other site 198214012706 DNA interaction; other site 198214012707 Metal-binding active site; metal-binding site 198214012708 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198214012709 intersubunit interface [polypeptide binding]; other site 198214012710 active site 198214012711 Zn2+ binding site [ion binding]; other site 198214012712 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198214012713 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 198214012714 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198214012715 dimer interface [polypeptide binding]; other site 198214012716 ssDNA binding site [nucleotide binding]; other site 198214012717 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198214012718 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 198214012719 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 198214012720 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 198214012721 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 198214012722 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790648 (265 aa). BLAST with identity of 97% in 185 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214012723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214012724 Transposase; Region: HTH_Tnp_1; pfam01527 198214012725 HTH-like domain; Region: HTH_21; pfam13276 198214012726 Integrase core domain; Region: rve; pfam00665 198214012727 putative transposase OrfB; Reviewed; Region: PHA02517 198214012728 HTH-like domain; Region: HTH_21; pfam13276 198214012729 Integrase core domain; Region: rve; pfam00665 198214012730 Integrase core domain; Region: rve_3; pfam13683 198214012731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214012732 Transposase; Region: HTH_Tnp_1; pfam01527 198214012733 Uncharacterized conserved protein [Function unknown]; Region: COG3586 198214012734 endoribonuclease SymE; Provisional; Region: PRK13605 198214012735 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 198214012736 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 198214012737 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 198214012738 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 198214012739 HsdM N-terminal domain; Region: HsdM_N; pfam12161 198214012740 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 198214012741 Methyltransferase domain; Region: Methyltransf_26; pfam13659 198214012742 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 198214012743 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 198214012744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198214012745 ATP binding site [chemical binding]; other site 198214012746 putative Mg++ binding site [ion binding]; other site 198214012747 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 198214012748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012749 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012750 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012751 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012752 L-lactate permease; Region: Lactate_perm; cl00701 198214012753 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 198214012754 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198214012755 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 198214012756 Uncharacterized small protein [Function unknown]; Region: COG2879 198214012757 carbon starvation protein A; Provisional; Region: PRK15015 198214012758 Carbon starvation protein CstA; Region: CstA; pfam02554 198214012759 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198214012760 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 198214012761 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 198214012762 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 198214012763 Cupin; Region: Cupin_6; pfam12852 198214012764 Cupin domain; Region: Cupin_2; pfam07883 198214012765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214012766 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 198214012767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214012768 putative substrate translocation pore; other site 198214012769 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198214012770 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 198214012771 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 198214012772 putative substrate binding pocket [chemical binding]; other site 198214012773 trimer interface [polypeptide binding]; other site 198214012774 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 198214012775 putative active site [active] 198214012776 putative metal binding site [ion binding]; other site 198214012777 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 198214012778 NAD binding site [chemical binding]; other site 198214012779 catalytic residues [active] 198214012780 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 198214012781 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 198214012782 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 198214012783 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 198214012784 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198214012785 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 198214012786 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198214012787 dimer interface [polypeptide binding]; other site 198214012788 ligand binding site [chemical binding]; other site 198214012789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214012790 dimerization interface [polypeptide binding]; other site 198214012791 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198214012792 dimer interface [polypeptide binding]; other site 198214012793 putative CheW interface [polypeptide binding]; other site 198214012794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214012795 D-galactonate transporter; Region: 2A0114; TIGR00893 198214012796 putative substrate translocation pore; other site 198214012797 Transcriptional regulators [Transcription]; Region: GntR; COG1802 198214012798 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198214012799 Similar to Escherichia coli K12 oxidoreductase gi: 1790819 (346 aa). BLAST with identity of 98% in 346 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214012800 phosphoglycerol transferase I; Provisional; Region: PRK03776 198214012801 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 198214012802 hypothetical protein; Provisional; Region: PRK11667 198214012803 DNA replication protein DnaC; Validated; Region: PRK07952 198214012804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214012805 Walker A motif; other site 198214012806 ATP binding site [chemical binding]; other site 198214012807 Walker B motif; other site 198214012808 primosomal protein DnaI; Provisional; Region: PRK02854 198214012809 hypothetical protein; Provisional; Region: PRK09917 198214012810 Uncharacterized conserved protein [Function unknown]; Region: COG2966 198214012811 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 198214012812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214012813 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214012814 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214012815 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198214012817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214012818 DNA binding residues [nucleotide binding] 198214012819 dimerization interface [polypeptide binding]; other site 198214012820 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 198214012821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198214012822 DNA binding residues [nucleotide binding] 198214012823 dimerization interface [polypeptide binding]; other site 198214012824 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 198214012825 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198214012826 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 198214012827 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 198214012828 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 198214012829 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 198214012830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198214012831 S-adenosylmethionine binding site [chemical binding]; other site 198214012832 DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050 198214012833 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 198214012834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214012835 Coenzyme A binding pocket [chemical binding]; other site 198214012836 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 198214012837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214012838 motif II; other site 198214012839 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 198214012840 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 198214012841 G1 box; other site 198214012842 putative GEF interaction site [polypeptide binding]; other site 198214012843 GTP/Mg2+ binding site [chemical binding]; other site 198214012844 Switch I region; other site 198214012845 G2 box; other site 198214012846 G3 box; other site 198214012847 Switch II region; other site 198214012848 G4 box; other site 198214012849 G5 box; other site 198214012850 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 198214012851 Elongation Factor G, domain II; Region: EFG_II; pfam14492 198214012852 periplasmic protein; Provisional; Region: PRK10568 198214012853 BON domain; Region: BON; pfam04972 198214012854 BON domain; Region: BON; pfam04972 198214012855 Small integral membrane protein [Function unknown]; Region: COG5487 198214012856 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 198214012857 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 198214012858 active site 198214012859 nucleophile elbow; other site 198214012860 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198214012861 active site 198214012862 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 198214012863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198214012864 FeS/SAM binding site; other site 198214012865 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 198214012866 hypothetical protein; Provisional; Region: PRK10977 198214012867 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 198214012868 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 198214012869 intersubunit interface [polypeptide binding]; other site 198214012870 active site 198214012871 catalytic residue [active] 198214012872 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 198214012873 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198214012874 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198214012875 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 198214012876 phosphopentomutase; Provisional; Region: PRK05362 198214012877 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 198214012878 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198214012879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214012880 non-specific DNA binding site [nucleotide binding]; other site 198214012881 salt bridge; other site 198214012882 sequence-specific DNA binding site [nucleotide binding]; other site 198214012883 Similar to Escherichia coli K12 lipoate-protein ligase A gi: 1790846 (339 aa). BLAST with identity of 97% in 338 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214012884 hypothetical protein; Provisional; Region: PRK11246 198214012885 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 198214012886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198214012887 motif II; other site 198214012888 DNA repair protein RadA; Region: sms; TIGR00416 198214012889 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 198214012890 Walker A motif/ATP binding site; other site 198214012891 ATP binding site [chemical binding]; other site 198214012892 Walker B motif; other site 198214012893 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 198214012894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198214012895 non-specific DNA binding site [nucleotide binding]; other site 198214012896 salt bridge; other site 198214012897 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 198214012898 sequence-specific DNA binding site [nucleotide binding]; other site 198214012899 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 198214012900 active site 198214012901 (T/H)XGH motif; other site 198214012902 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 198214012903 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 198214012904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214012905 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 198214012906 ABC transporter; Region: ABC_tran_2; pfam12848 198214012907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198214012908 lytic murein transglycosylase; Provisional; Region: PRK11619 198214012909 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 198214012910 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214012911 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214012912 catalytic residue [active] 198214012913 Trp operon repressor [Transcription]; Region: TrpR; COG2973 198214012914 Similar to Escherichia coli K12 conserved hypothetical protein gi: 1790855 (174 aa). BLAST with identity of 95% in 172 aa. This CDS ontains frameshift. The sequence has been checked and is believed to be correct. 198214012915 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198214012916 catalytic core [active] 198214012917 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 198214012918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214012919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214012920 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 198214012921 hypothetical protein; Provisional; Region: PRK10756 198214012922 DNA-binding response regulator CreB; Provisional; Region: PRK11083 198214012923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214012924 active site 198214012925 phosphorylation site [posttranslational modification] 198214012926 intermolecular recognition site; other site 198214012927 dimerization interface [polypeptide binding]; other site 198214012928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214012929 DNA binding site [nucleotide binding] 198214012930 sensory histidine kinase CreC; Provisional; Region: PRK11100 198214012931 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198214012932 dimerization interface [polypeptide binding]; other site 198214012933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198214012934 dimer interface [polypeptide binding]; other site 198214012935 phosphorylation site [posttranslational modification] 198214012936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198214012937 ATP binding site [chemical binding]; other site 198214012938 Mg2+ binding site [ion binding]; other site 198214012939 G-X-G motif; other site 198214012940 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 198214012941 two-component response regulator; Provisional; Region: PRK11173 198214012942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198214012943 active site 198214012944 phosphorylation site [posttranslational modification] 198214012945 intermolecular recognition site; other site 198214012946 dimerization interface [polypeptide binding]; other site 198214012947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198214012948 DNA binding site [nucleotide binding] 198214012949 putative RNA methyltransferase; Provisional; Region: PRK10433 198214012950 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 198214012951 Integrase core domain; Region: rve_3; pfam13683 198214012952 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 198214012953 active site 198214012954 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198214012955 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 198214012956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214012957 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214012958 HTH-like domain; Region: HTH_21; pfam13276 198214012959 putative transposase OrfB; Reviewed; Region: PHA02517 198214012960 HTH-like domain; Region: HTH_21; pfam13276 198214012961 Integrase core domain; Region: rve; pfam00665 198214012962 Integrase core domain; Region: rve_3; pfam13683 198214012963 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 198214012964 type III effector phosphothreonine lyase; Provisional; Region: PRK15245 198214012965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 198214012966 Transposase; Region: DDE_Tnp_ISL3; pfam01610 198214012967 Transposase; Region: DDE_Tnp_ISL3; pfam01610 198214012968 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012969 Putative transposase; Region: Y2_Tnp; pfam04986 198214012970 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198214012971 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198214012972 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214012973 Transposase; Region: HTH_Tnp_1; pfam01527 198214012974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214012975 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214012976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214012977 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214012978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214012979 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214012980 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214012981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 198214012982 Transposase, Mutator family; Region: Transposase_mut; cl19537 198214012983 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 198214012984 Integrase core domain; Region: rve; pfam00665 198214012985 Integrase core domain; Region: rve_2; pfam13333 198214012986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 198214012987 Helix-turn-helix domain; Region: HTH_38; pfam13936 198214012988 DNA-binding interface [nucleotide binding]; DNA binding site 198214012989 Integrase core domain; Region: rve; pfam00665 198214012990 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214012991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 198214012992 transposase/IS protein; Provisional; Region: PRK09183 198214012993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214012994 Walker A motif; other site 198214012995 ATP binding site [chemical binding]; other site 198214012996 Walker B motif; other site 198214012997 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214012998 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 198214012999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 198214013000 Magnesium ion binding site [ion binding]; other site 198214013001 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 198214013002 ParB-like nuclease domain; Region: ParB; smart00470 198214013003 ParB family; Region: ParB; pfam08775 198214013004 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214013005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214013006 Similar to Shigella flexneri putative reverse transcriptase ref: NP_085197.1 (405 aa). BLAST with identity of 97% in 405 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214013007 HTH-like domain; Region: HTH_21; pfam13276 198214013008 Integrase core domain; Region: rve; pfam00665 198214013009 Integrase core domain; Region: rve_3; pfam13683 198214013010 Transposase; Region: HTH_Tnp_1; cl17663 198214013011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013012 Integrase core domain; Region: rve; pfam00665 198214013013 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214013014 Putative transposase; Region: Y2_Tnp; pfam04986 198214013015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013016 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214013017 Helix-turn-helix domain; Region: HTH_28; pfam13518 198214013018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214013019 Walker A motif; other site 198214013020 ATP binding site [chemical binding]; other site 198214013021 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198214013022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214013023 Integrase core domain; Region: rve_3; pfam13683 198214013024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214013025 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214013026 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214013027 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214013028 Similar to Shigella flexneri putative transposase for IS110 ref: NP_085282.1 (398 aa). BLAST with identity of 98% in 398 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214013029 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198214013030 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214013031 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214013032 Transposase; Region: HTH_Tnp_1; cl17663 198214013033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013034 HTH-like domain; Region: HTH_21; pfam13276 198214013035 Integrase core domain; Region: rve; pfam00665 198214013036 Integrase core domain; Region: rve_3; pfam13683 198214013037 putative transposase OrfB; Reviewed; Region: PHA02517 198214013038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013039 Transposase; Region: HTH_Tnp_1; pfam01527 198214013040 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198214013041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 198214013042 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 198214013043 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214013044 Putative transposase; Region: Y2_Tnp; pfam04986 198214013045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 198214013046 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 198214013047 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 198214013048 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214013049 Transposase; Region: HTH_Tnp_1; cl17663 198214013050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013051 HTH-like domain; Region: HTH_21; pfam13276 198214013052 Integrase core domain; Region: rve; pfam00665 198214013053 Integrase core domain; Region: rve_3; pfam13683 198214013054 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214013055 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214013056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214013057 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198214013058 Walker A motif; other site 198214013059 ATP binding site [chemical binding]; other site 198214013060 Walker B motif; other site 198214013061 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 198214013062 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 198214013063 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 198214013064 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214013065 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198214013066 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214013067 Putative transposase; Region: Y2_Tnp; pfam04986 198214013068 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 198214013069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 198214013070 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214013071 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 198214013072 Homeodomain-like domain; Region: HTH_23; pfam13384 198214013073 Winged helix-turn helix; Region: HTH_29; pfam13551 198214013074 Homeodomain-like domain; Region: HTH_32; pfam13565 198214013075 DDE superfamily endonuclease; Region: DDE_3; pfam13358 198214013076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214013077 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214013078 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214013079 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214013080 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214013081 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 198214013082 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214013083 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214013084 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198214013085 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214013086 Transposase; Region: HTH_Tnp_1; cl17663 198214013087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013088 HTH-like domain; Region: HTH_21; pfam13276 198214013089 Integrase core domain; Region: rve; pfam00665 198214013090 Integrase core domain; Region: rve_3; pfam13683 198214013091 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 198214013092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198214013093 putative substrate translocation pore; other site 198214013094 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198214013095 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214013096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 198214013097 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214013098 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214013099 HTH-like domain; Region: HTH_21; pfam13276 198214013100 Integrase core domain; Region: rve; pfam00665 198214013101 Integrase core domain; Region: rve_3; pfam13683 198214013102 Transposase; Region: HTH_Tnp_1; cl17663 198214013103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013104 transposase/IS protein; Provisional; Region: PRK09183 198214013105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198214013106 Walker A motif; other site 198214013107 ATP binding site [chemical binding]; other site 198214013108 Walker B motif; other site 198214013109 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214013110 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214013111 Putative transposase; Region: Y2_Tnp; pfam04986 198214013112 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 198214013113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198214013114 membrane-bound complex binding site; other site 198214013115 hinge residues; other site 198214013116 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 198214013117 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198214013118 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214013119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198214013120 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 198214013121 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 198214013122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 198214013123 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 198214013124 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198214013125 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214013126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214013127 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214013128 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 198214013129 Similar to Shigella flexneri orf, conserved hypothetical protein ref: NP_085259.1 (212 aa). BLAST with identity of 99% in 211 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214013130 IS2 transposase TnpB; Reviewed; Region: PRK09409 198214013131 HTH-like domain; Region: HTH_21; pfam13276 198214013132 Integrase core domain; Region: rve; pfam00665 198214013133 Integrase core domain; Region: rve_3; pfam13683 198214013134 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214013135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013136 putative transposase OrfB; Reviewed; Region: PHA02517 198214013137 HTH-like domain; Region: HTH_21; pfam13276 198214013138 Integrase core domain; Region: rve; pfam00665 198214013139 Integrase core domain; Region: rve_3; pfam13683 198214013140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013141 Transposase; Region: HTH_Tnp_1; pfam01527 198214013142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198214013143 Coenzyme A binding pocket [chemical binding]; other site 198214013144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 198214013145 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214013146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214013147 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214013148 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214013149 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214013150 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214013151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214013152 Homeodomain-like domain; Region: HTH_23; pfam13384 198214013153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013154 Transposase; Region: HTH_Tnp_1; pfam01527 198214013155 Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128 198214013156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013157 Transposase; Region: HTH_Tnp_1; pfam01527 198214013158 HTH-like domain; Region: HTH_21; pfam13276 198214013159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198214013160 Integrase core domain; Region: rve; pfam00665 198214013161 Integrase core domain; Region: rve_3; pfam13683 198214013162 Integrase core domain; Region: rve; pfam00665 198214013163 Integrase core domain; Region: rve_2; pfam13333 198214013164 Transposase Tn5 dimerization domain; Region: Dimer_Tnp_Tn5; pfam02281 198214013165 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214013166 Y-family of DNA polymerases; Region: PolY; cl12025 198214013167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214013168 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214013169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 198214013170 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 198214013171 DNA-binding interface [nucleotide binding]; DNA binding site 198214013172 Integrase core domain; Region: rve; pfam00665 198214013173 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 198214013174 ParB-like nuclease domain; Region: ParB; smart00470 198214013175 ParB family; Region: ParB; pfam08775 198214013176 Phosphopantetheine attachment site; Region: PP-binding; cl09936 198214013177 Salmonella invasion protein A; Region: SipA; cl19731 198214013178 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 198214013179 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 198214013180 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 198214013181 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 198214013182 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 198214013183 Tetratricopeptide repeat; Region: TPR_3; pfam07720 198214013184 Tetratricopeptide repeat; Region: TPR_3; pfam07720 198214013185 IpaB/EvcA family; Region: IpaB_EvcA; pfam03278 198214013186 chaperone protein SicP; Provisional; Region: PRK15329 198214013187 Enterobacterial virulence protein IpgD; Region: IpgD; cl19613 198214013188 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 198214013189 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 198214013190 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198214013191 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198214013192 catalytic residue [active] 198214013193 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 198214013194 Type III secretion needle MxiH like; Region: MxiH; cl09641 198214013195 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 198214013196 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 198214013197 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; pfam09482 198214013198 invasion protein OrgB; Provisional; Region: PRK15322 198214013199 Pilot protein MxiM; Region: MxiM; pfam11441 198214013200 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198214013201 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198214013202 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 198214013203 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198214013204 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 198214013205 type III secretion system regulator InvE; Provisional; Region: PRK15338 198214013206 HrpJ-like domain; Region: HrpJ; pfam07201 198214013207 type III secretion system protein InvA; Provisional; Region: PRK15337 198214013208 Invasion protein B family; Region: Invas_SpaK; pfam03519 198214013209 ATP synthase SpaL; Validated; Region: PRK08149 198214013210 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198214013211 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198214013212 Walker A motif; other site 198214013213 ATP binding site [chemical binding]; other site 198214013214 Walker B motif; other site 198214013215 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 198214013216 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 198214013217 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 198214013218 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 198214013219 type III secretion system protein SpaS; Validated; Region: PRK08156 198214013220 HTH-like domain; Region: HTH_21; pfam13276 198214013221 Integrase core domain; Region: rve; pfam00665 198214013222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013223 Transposase; Region: HTH_Tnp_1; pfam01527 198214013224 Integrase core domain; Region: rve_3; pfam13683 198214013225 Similar to Shigella flexneri IS1294 transposase ref: NP_085231.1 (399 aa). BLAST with identity of 98% in 286 aa. This CDS has been truncated. The sequence has been checked and is believed to be correct. 198214013226 HTH-like domain; Region: HTH_21; pfam13276 198214013227 Transposase; Region: HTH_Tnp_1; cl17663 198214013228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 198214013229 Transposase; Region: DDE_Tnp_ISL3; pfam01610 198214013230 Transposase; Region: HTH_Tnp_1; cl17663 198214013231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013232 HTH-like domain; Region: HTH_21; pfam13276 198214013233 Integrase core domain; Region: rve; pfam00665 198214013234 Integrase core domain; Region: rve_3; pfam13683 198214013235 Transposase; Region: DDE_Tnp_ISL3; pfam01610 198214013236 Putative transposase; Region: Y2_Tnp; pfam04986 198214013237 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 198214013238 nucleic acid binding site [nucleotide binding]; other site 198214013239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198214013240 HTH-like domain; Region: HTH_21; pfam13276 198214013241 Transposase; Region: HTH_Tnp_1; cl17663 198214013242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013243 EspG protein; Region: EspG; pfam06872 198214013244 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 198214013245 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 198214013246 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 198214013247 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198214013248 Transposase; Region: HTH_Tnp_1; cl17663 198214013249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013250 HTH-like domain; Region: HTH_21; pfam13276 198214013251 Integrase core domain; Region: rve; pfam00665 198214013252 Integrase core domain; Region: rve_3; pfam13683 198214013253 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 198214013254 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 198214013255 active site 198214013256 metal binding site [ion binding]; metal-binding site 198214013257 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198214013258 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 198214013259 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 198214013260 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 198214013261 putative active site [active] 198214013262 putative NTP binding site [chemical binding]; other site 198214013263 putative nucleic acid binding site [nucleotide binding]; other site 198214013264 Integrase core domain; Region: rve; pfam00665 198214013265 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 198214013266 active site 198214013267 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198214013268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 198214013269 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 198214013270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 198214013271 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 198214013272 RelB antitoxin; Region: RelB; cl01171 198214013273 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 198214013274 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 198214013275 Mg binding site [ion binding]; other site 198214013276 nucleotide binding site [chemical binding]; other site 198214013277 putative protofilament interface [polypeptide binding]; other site 198214013278 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 198214013279 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 198214013280 putative methylase; Provisional; Region: PRK13699 198214013281 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 198214013282 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 198214013283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198214013284 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198214013285 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198214013286 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214013287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214013288 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214013289 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214013290 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214013291 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214013292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214013293 Homeodomain-like domain; Region: HTH_23; pfam13384 198214013294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013295 Transposase; Region: HTH_Tnp_1; pfam01527 198214013296 HTH-like domain; Region: HTH_21; pfam13276 198214013297 Integrase core domain; Region: rve; pfam00665 198214013298 IS2 repressor TnpA; Reviewed; Region: PRK09413 198214013299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013300 Papain fold toxin 1; Region: Tox-PL; pfam15644 198214013301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 198214013302 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 198214013303 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 198214013304 Homeodomain-like domain; Region: HTH_23; pfam13384 198214013305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013306 Transposase; Region: HTH_Tnp_1; pfam01527 198214013307 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 198214013308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214013309 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 198214013310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 198214013311 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 198214013312 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214013313 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214013314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 198214013315 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198214013316 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 198214013317 Predicted transcriptional regulator [Transcription]; Region: COG3905 198214013318 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 198214013319 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 198214013320 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 198214013321 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214013322 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 198214013323 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 198214013324 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 198214013325 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 198214013326 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214013327 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 198214013328 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 198214013329 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214013330 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198214013331 active site 198214013332 ATP binding site [chemical binding]; other site 198214013333 Similar to Shigella flexneri orf, conserved hypothetical protein ref: NP_085397.1 (439 aa). BLAST with identity of 77% in 438 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214013334 Transposase; Region: HTH_Tnp_1; cl17663 198214013335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013336 HTH-like domain; Region: HTH_21; pfam13276 198214013337 Integrase core domain; Region: rve; pfam00665 198214013338 Integrase core domain; Region: rve_3; pfam13683 198214013339 putative transposase OrfB; Reviewed; Region: PHA02517 198214013340 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 198214013341 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 198214013342 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198214013343 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198214013344 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 198214013345 putative active site [active] 198214013346 putative metal binding site [ion binding]; other site 198214013347 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198214013348 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198214013349 Protein of unknown function (DUF535); Region: DUF535; pfam04393 198214013350 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198214013351 putative acyl-acceptor binding pocket; other site 198214013352 Winged helix-turn helix; Region: HTH_29; pfam13551 198214013353 Homeodomain-like domain; Region: HTH_23; pfam13384 198214013354 Homeodomain-like domain; Region: HTH_32; pfam13565 198214013355 DDE superfamily endonuclease; Region: DDE_3; pfam13358 198214013356 Similar to Shigella flexneri orf, conserved hypothetical protein ref: NP_085323.1 (272 aa). BLAST with identity of 100% in 272 aa. This CDS contains an in-frame stop codon. The sequence has been checked and is believed to be correct. 198214013357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013358 Transposase; Region: HTH_Tnp_1; pfam01527 198214013359 conjugal transfer protein TraD; Provisional; Region: PRK13700 198214013360 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 198214013361 oligomeric interface; other site 198214013362 putative active site [active] 198214013363 homodimer interface [polypeptide binding]; other site 198214013364 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 198214013365 TrwC relaxase; Region: TrwC; cl19905 198214013366 TrwC relaxase; Region: TrwC; cl19905 198214013367 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK14712 198214013368 AAA domain; Region: AAA_30; pfam13604 198214013369 DNA helicase TraI; Region: TraI; pfam07057 198214013370 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 198214013371 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 198214013372 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 198214013373 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 198214013374 putative kissing complex interaction region; other site 198214013375 putative RNA binding sites [nucleotide binding]; other site 198214013376 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 198214013377 Catalytic site; other site 198214013378 putative transposase OrfB; Reviewed; Region: PHA02517 198214013379 HTH-like domain; Region: HTH_21; pfam13276 198214013380 Integrase core domain; Region: rve; pfam00665 198214013381 Integrase core domain; Region: rve_3; pfam13683 198214013382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013383 Transposase; Region: HTH_Tnp_1; pfam01527 198214013384 Staphylococcal nuclease homologue; Region: SNase; cl00140 198214013385 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 198214013386 replication protein; Provisional; Region: PRK13702 198214013387 leader peptide RepL; Provisional; Region: PRK13716 198214013388 replication protein; Provisional; Region: PRK13750 198214013389 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 198214013390 Putative transposase; Region: Y2_Tnp; pfam04986 198214013391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 198214013392 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 198214013393 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 198214013394 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 198214013395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013396 Transposase; Region: HTH_Tnp_1; pfam01527 198214013397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198214013398 Transposase; Region: HTH_Tnp_1; cl17663 198214013399 putative transposase OrfB; Reviewed; Region: PHA02517 198214013400 HTH-like domain; Region: HTH_21; pfam13276 198214013401 Integrase core domain; Region: rve; pfam00665 198214013402 Integrase core domain; Region: rve_3; pfam13683 198214013403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198214013404 Integrase core domain; Region: rve_3; cl15866 198214013405 Omptin family; Region: Omptin; pfam01278 198214013406 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290