-- dump date 20140620_065414 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_687595.1 110804075 4207799 336..2798 1 NC_008258.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2798 thrA 4207799 thrA Shigella flexneri 5 str. 8401 bifunctional aspartokinase I/homoserine dehydrogenase I YP_687595.1 336 D 373384 CDS YP_687596.1 110804076 4207800 2800..3732 1 NC_008258.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3732 thrB 4207800 thrB Shigella flexneri 5 str. 8401 homoserine kinase YP_687596.1 2800 D 373384 CDS YP_687597.1 110804077 4207801 3733..5019 1 NC_008258.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5019 thrC 4207801 thrC Shigella flexneri 5 str. 8401 threonine synthase YP_687597.1 3733 D 373384 CDS YP_687598.1 110804078 4207802 5242..5529 1 NC_008258.1 hypothetical protein 5529 4207802 SFV_0004 Shigella flexneri 5 str. 8401 hypothetical protein YP_687598.1 5242 D 373384 CDS YP_687599.1 110804079 4207803 complement(5682..6458) 1 NC_008258.1 Code: S; COG: COG3022; hypothetical protein 6458 yaaA 4207803 yaaA Shigella flexneri 5 str. 8401 hypothetical protein YP_687599.1 5682 R 373384 CDS YP_687600.2 162139365 4207805 8303..9256 1 NC_008258.1 Code: G; COG: COG0176; transaldolase B 9256 talB 4207805 talB Shigella flexneri 5 str. 8401 transaldolase B YP_687600.2 8303 D 373384 CDS YP_687601.1 110804081 4207806 9368..9958 1 NC_008258.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9958 mogA 4207806 mogA Shigella flexneri 5 str. 8401 molybdenum cofactor biosynthesis protein MogA YP_687601.1 9368 D 373384 CDS YP_687602.1 110804082 4207807 complement(9993..10559) 1 NC_008258.1 Code: S; COG: COG1584; hypothetical protein 10559 yaaH 4207807 yaaH Shigella flexneri 5 str. 8401 hypothetical protein YP_687602.1 9993 R 373384 CDS YP_687603.1 110804083 4207808 complement(10708..11421) 1 NC_008258.1 Code: S; COG: COG4735; hypothetical protein 11421 4207808 SFV_0010 Shigella flexneri 5 str. 8401 hypothetical protein YP_687603.1 10708 R 373384 CDS YP_687604.1 110804084 4207809 complement(11447..11851) 1 NC_008258.1 hypothetical protein 11851 yaaI 4207809 yaaI Shigella flexneri 5 str. 8401 hypothetical protein YP_687604.1 11447 R 373384 CDS YP_687605.1 110804085 4207810 12228..14144 1 NC_008258.1 DNA biosynthesis; heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14144 dnaK 4207810 dnaK Shigella flexneri 5 str. 8401 molecular chaperone DnaK YP_687605.1 12228 D 373384 CDS YP_687606.1 110804086 4207811 14233..15363 1 NC_008258.1 heat shock protein; chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 15363 dnaJ 4207811 dnaJ Shigella flexneri 5 str. 8401 molecular chaperone DnaJ YP_687606.1 14233 D 373384 CDS YP_687607.1 110804087 4210405 16206..17372 1 NC_008258.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 17372 nhaA 4210405 nhaA Shigella flexneri 5 str. 8401 pH-dependent sodium/proton antiporter YP_687607.1 16206 D 373384 CDS YP_687608.1 110804088 4210406 17438..18337 1 NC_008258.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18337 nhaR 4210406 nhaR Shigella flexneri 5 str. 8401 transcriptional activator NhaR YP_687608.1 17438 D 373384 CDS YP_687609.1 110804089 4210407 complement(18750..19253) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 19253 insB 4210407 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_687609.1 18750 R 373384 CDS YP_687610.1 110804090 4210408 19328..19531 1 NC_008258.1 IS1 encoded protein 19531 4210408 SFV_0017 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_687610.1 19328 D 373384 CDS YP_687611.1 110804091 4210409 complement(19836..20099) 1 NC_008258.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 20099 rpsT 4210409 rpsT Shigella flexneri 5 str. 8401 30S ribosomal protein S20 YP_687611.1 19836 R 373384 CDS YP_687612.1 110804092 4210410 20428..21369 1 NC_008258.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 21369 ribF 4210410 ribF Shigella flexneri 5 str. 8401 bifunctional riboflavin kinase/FMN adenylyltransferase YP_687612.1 20428 D 373384 CDS YP_687613.1 110804093 4210411 21460..24228 1 NC_008258.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 24228 ileS 4210411 ileS Shigella flexneri 5 str. 8401 isoleucyl-tRNA synthetase YP_687613.1 21460 D 373384 CDS YP_687614.1 110804094 4210412 24228..24722 1 NC_008258.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 24722 lspA 4210412 lspA Shigella flexneri 5 str. 8401 lipoprotein signal peptidase YP_687614.1 24228 D 373384 CDS YP_687615.1 110804095 4210413 24809..25258 1 NC_008258.1 a rotamase; Code: O; COG: COG1047; peptidyl-prolyl cis- trans isomerase 25258 slpA 4210413 slpA Shigella flexneri 5 str. 8401 peptidyl-prolyl cis- trans isomerase YP_687615.1 24809 D 373384 CDS YP_687616.1 110804096 4210414 25260..26210 1 NC_008258.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 26210 ispH 4210414 ispH Shigella flexneri 5 str. 8401 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_687616.1 25260 D 373384 CDS YP_687617.1 110804097 4210415 26276..27190 1 NC_008258.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 27190 yaaF 4210415 yaaF Shigella flexneri 5 str. 8401 ribonucleoside hydrolase RihC YP_687617.1 26276 D 373384 CDS YP_687618.2 229774944 4210416 27357..28178 1 NC_008258.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 28178 dapB 4210416 dapB Shigella flexneri 5 str. 8401 dihydrodipicolinate reductase YP_687618.2 27357 D 373384 CDS YP_687619.1 110804099 4210417 28634..29782 1 NC_008258.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 29782 carA 4210417 carA Shigella flexneri 5 str. 8401 carbamoyl phosphate synthase small subunit YP_687619.1 28634 D 373384 CDS YP_687620.1 110804100 4210418 29800..33021 1 NC_008258.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 33021 carB 4210418 carB Shigella flexneri 5 str. 8401 carbamoyl phosphate synthase large subunit YP_687620.1 29800 D 373384 CDS YP_687621.1 110804101 4210419 33178..33678 1 NC_008258.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 33678 caiF 4210419 caiF Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator CaiF YP_687621.1 33178 D 373384 CDS YP_687622.1 110804102 4210420 complement(33764..34375) 1 NC_008258.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 34375 caiE 4210420 caiE Shigella flexneri 5 str. 8401 carnitine operon protein CaiE YP_687622.1 33764 R 373384 CDS YP_687623.1 110804103 4210421 complement(34360..35253) 1 NC_008258.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 35253 caiD 4210421 caiD Shigella flexneri 5 str. 8401 carnitinyl-CoA dehydratase YP_687623.1 34360 R 373384 CDS YP_687624.1 110804104 4210422 complement(35274..36806) 1 NC_008258.1 Code: IQ; COG: COG0318; crotonobetaine/carnitine-CoA ligase 36806 caiC 4210422 caiC Shigella flexneri 5 str. 8401 crotonobetaine/carnitine-CoA ligase YP_687624.1 35274 R 373384 CDS YP_687625.1 110804105 4210423 complement(36880..38097) 1 NC_008258.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 38097 caiB 4210423 caiB Shigella flexneri 5 str. 8401 crotonobetainyl-CoA:carnitine CoA-transferase YP_687625.1 36880 R 373384 CDS YP_687626.1 110804106 4210366 complement(38226..39368) 1 NC_008258.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 39368 caiA 4210366 caiA Shigella flexneri 5 str. 8401 crotonobetainyl-CoA dehydrogenase YP_687626.1 38226 R 373384 CDS YP_687627.1 110804107 4210367 complement(39399..40913) 1 NC_008258.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 40913 caiT 4210367 caiT Shigella flexneri 5 str. 8401 L-carnitine/gamma-butyrobetaine antiporter YP_687627.1 39399 R 373384 CDS YP_687628.1 110804108 4210368 41385..42155 1 NC_008258.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 42155 fixA 4210368 fixA Shigella flexneri 5 str. 8401 electron transfer flavoprotein FixA YP_687628.1 41385 D 373384 CDS YP_687629.1 110804109 4210370 43162..44448 1 NC_008258.1 electron transport; FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 44448 fixC 4210370 fixC Shigella flexneri 5 str. 8401 oxidoreductase FixC YP_687629.1 43162 D 373384 CDS YP_687630.1 110804110 4210371 44445..44732 1 NC_008258.1 Code: C; COG: COG2440; ferredoxin 44732 fixX 4210371 fixX Shigella flexneri 5 str. 8401 ferredoxin YP_687630.1 44445 D 373384 CDS YP_687631.1 110804111 4210372 44791..46185 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 46185 yaaU 4210372 yaaU Shigella flexneri 5 str. 8401 transport protein YP_687631.1 44791 D 373384 CDS YP_687632.1 110804112 4210373 46233..46763 1 NC_008258.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 46763 yabF 4210373 yabF Shigella flexneri 5 str. 8401 glutathione-regulated potassium-efflux system ancillary protein KefF YP_687632.1 46233 D 373384 CDS YP_687633.1 110804113 4210374 46756..48618 1 NC_008258.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 48618 kefC 4210374 kefC Shigella flexneri 5 str. 8401 glutathione-regulated potassium-efflux system protein KefC YP_687633.1 46756 D 373384 CDS YP_687634.1 110804114 4210375 48809..49288 1 NC_008258.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 49288 folA 4210375 folA Shigella flexneri 5 str. 8401 dihydrofolate reductase YP_687634.1 48809 D 373384 CDS YP_687635.1 110804115 4210376 complement(49366..50208) 1 NC_008258.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 50208 apaH 4210376 apaH Shigella flexneri 5 str. 8401 diadenosine tetraphosphatase YP_687635.1 49366 R 373384 CDS YP_687636.1 110804116 4210377 complement(50215..50592) 1 NC_008258.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 50592 apaG 4210377 apaG Shigella flexneri 5 str. 8401 ApaG protein YP_687636.1 50215 R 373384 CDS YP_687637.1 110804117 4210378 complement(50595..51416) 1 NC_008258.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 51416 ksgA 4210378 ksgA Shigella flexneri 5 str. 8401 dimethyladenosine transferase YP_687637.1 50595 R 373384 CDS YP_687638.1 110804118 4210379 complement(51413..52402) 1 NC_008258.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 52402 pdxA 4210379 pdxA Shigella flexneri 5 str. 8401 4-hydroxythreonine-4-phosphate dehydrogenase YP_687638.1 51413 R 373384 CDS YP_687639.1 110804119 4210380 complement(52402..53688) 1 NC_008258.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 53688 surA 4210380 surA Shigella flexneri 5 str. 8401 peptidyl-prolyl cis-trans isomerase SurA YP_687639.1 52402 R 373384 CDS YP_687640.1 110804120 4210381 complement(53741..56095) 1 NC_008258.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 56095 imp 4210381 imp Shigella flexneri 5 str. 8401 organic solvent tolerance protein YP_687640.1 53741 R 373384 CDS YP_687641.1 110804121 4210382 56350..57165 1 NC_008258.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 57165 djlA 4210382 djlA Shigella flexneri 5 str. 8401 Dna-J like membrane chaperone protein YP_687641.1 56350 D 373384 CDS YP_687642.1 110804122 4210383 complement(57282..57941) 1 NC_008258.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 57941 yabO 4210383 yabO Shigella flexneri 5 str. 8401 23S rRNA/tRNA pseudouridine synthase A YP_687642.1 57282 R 373384 CDS YP_687643.1 110804123 4210384 complement(57953..60859) 1 NC_008258.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 60859 hepA 4210384 hepA Shigella flexneri 5 str. 8401 ATP-dependent helicase HepA YP_687643.1 57953 R 373384 CDS YP_687644.1 110804124 4210385 complement(61024..63375) 1 NC_008258.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 63375 polB 4210385 polB Shigella flexneri 5 str. 8401 DNA polymerase II YP_687644.1 61024 R 373384 CDS YP_687645.1 110804125 4209884 complement(63450..64145) 1 NC_008258.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 64145 araD 4209884 araD Shigella flexneri 5 str. 8401 L-ribulose-5-phosphate 4-epimerase YP_687645.1 63450 R 373384 CDS YP_687646.1 110804126 4209885 complement(64345..65847) 1 NC_008258.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 65847 araA 4209885 araA Shigella flexneri 5 str. 8401 L-arabinose isomerase YP_687646.1 64345 R 373384 CDS YP_687647.1 110804127 4209886 complement(65858..67558) 1 NC_008258.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 67558 araB 4209886 araB Shigella flexneri 5 str. 8401 ribulokinase YP_687647.1 65858 R 373384 CDS YP_687648.1 110804128 4209887 67897..68775 1 NC_008258.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 68775 araC 4209887 araC Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator AraC YP_687648.1 67897 D 373384 CDS YP_687649.1 110804129 4209888 68861..69625 1 NC_008258.1 Code: S; COG: COG0586; hypothetical protein 69625 yabI 4209888 yabI Shigella flexneri 5 str. 8401 hypothetical protein YP_687649.1 68861 D 373384 CDS YP_687650.1 110804130 4209889 complement(69739..70437) 1 NC_008258.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 70437 thiQ 4209889 thiQ Shigella flexneri 5 str. 8401 thiamine transporter ATP-binding subunit YP_687650.1 69739 R 373384 CDS YP_687651.1 110804131 4209890 complement(70421..72031) 1 NC_008258.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 72031 thiP 4209890 thiP Shigella flexneri 5 str. 8401 thiamine transporter membrane protein YP_687651.1 70421 R 373384 CDS YP_687652.1 110804132 4209891 complement(72007..72990) 1 NC_008258.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 72990 tbpA 4209891 tbpA Shigella flexneri 5 str. 8401 thiamine transporter substrate binding subunit YP_687652.1 72007 R 373384 CDS YP_687653.1 110804133 4209892 complement(73154..74809) 1 NC_008258.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 74809 yabN 4209892 yabN Shigella flexneri 5 str. 8401 transcriptional regulator SgrR YP_687653.1 73154 R 373384 CDS YP_687654.1 110804134 4209894 complement(76358..76963) 1 NC_008258.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 76963 leuD 4209894 leuD Shigella flexneri 5 str. 8401 isopropylmalate isomerase small subunit YP_687654.1 76358 R 373384 CDS YP_687655.1 110804135 4209895 complement(76974..78374) 1 NC_008258.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 78374 leuC 4209895 leuC Shigella flexneri 5 str. 8401 isopropylmalate isomerase large subunit YP_687655.1 76974 R 373384 CDS YP_687656.2 229774943 4209896 complement(78377..79468) 1 NC_008258.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 79468 leuB 4209896 leuB Shigella flexneri 5 str. 8401 3-isopropylmalate dehydrogenase YP_687656.2 78377 R 373384 CDS YP_687657.1 110804137 4209897 complement(79468..81039) 1 NC_008258.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 81039 leuA 4209897 leuA Shigella flexneri 5 str. 8401 2-isopropylmalate synthase YP_687657.1 79468 R 373384 CDS YP_687658.1 110804138 4209898 81702..82823 1 NC_008258.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 82823 leuO 4209898 leuO Shigella flexneri 5 str. 8401 leucine transcriptional activator YP_687658.1 81702 D 373384 CDS YP_687659.2 162139364 4209899 83141..84865 1 NC_008258.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 84865 ilvI 4209899 ilvI Shigella flexneri 5 str. 8401 acetolactate synthase 3 catalytic subunit YP_687659.2 83141 D 373384 CDS YP_687660.1 110804140 4209900 84868..85359 1 NC_008258.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 85359 ilvH 4209900 ilvH Shigella flexneri 5 str. 8401 acetolactate synthase 3 regulatory subunit YP_687660.1 84868 D 373384 CDS YP_687662.1 110804142 4209902 85539..86543 1 NC_008258.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 86543 fruR 4209902 fruR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator FruR YP_687662.1 85539 D 373384 CDS YP_687663.1 110804143 4209864 complement(86540..86785) 1 NC_008258.1 IS1 encoded protein 86785 4209864 SFV_0072 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_687663.1 86540 R 373384 CDS YP_687664.1 110804144 4209865 86860..87363 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 87363 insB 4209865 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_687664.1 86860 D 373384 CDS YP_687665.1 110804145 4209866 87922..88380 1 NC_008258.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 88380 yabB 4209866 yabB Shigella flexneri 5 str. 8401 cell division protein MraZ YP_687665.1 87922 D 373384 CDS YP_687666.1 110804146 4209867 88382..89323 1 NC_008258.1 Code: M; COG: COG0275; S-adenosyl-methyltransferase MraW 89323 mraW 4209867 mraW Shigella flexneri 5 str. 8401 S-adenosyl-methyltransferase MraW YP_687666.1 88382 D 373384 CDS YP_687667.1 110804147 4209868 89320..89685 1 NC_008258.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 89685 ftsL 4209868 ftsL Shigella flexneri 5 str. 8401 cell division protein FtsL YP_687667.1 89320 D 373384 CDS YP_687668.1 110804148 4209869 89701..91467 1 NC_008258.1 Code: M; COG: COG0768; peptidoglycan synthetase 91467 ftsI 4209869 ftsI Shigella flexneri 5 str. 8401 peptidoglycan synthetase YP_687668.1 89701 D 373384 CDS YP_687669.1 110804149 4209870 91454..92941 1 NC_008258.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 92941 murE 4209870 murE Shigella flexneri 5 str. 8401 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_687669.1 91454 D 373384 CDS YP_687670.1 110804150 4209871 92938..94296 1 NC_008258.1 Code: M; COG: COG0770; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 94296 murF 4209871 murF Shigella flexneri 5 str. 8401 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_687670.1 92938 D 373384 CDS YP_687671.1 110804151 4209872 94290..95372 1 NC_008258.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 95372 mraY 4209872 mraY Shigella flexneri 5 str. 8401 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_687671.1 94290 D 373384 CDS YP_687672.1 110804152 4209873 95375..96691 1 NC_008258.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 96691 murD 4209873 murD Shigella flexneri 5 str. 8401 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_687672.1 95375 D 373384 CDS YP_687673.1 110804153 4209874 96691..97935 1 NC_008258.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 97935 ftsW 4209874 ftsW Shigella flexneri 5 str. 8401 cell division protein FtsW YP_687673.1 96691 D 373384 CDS YP_687674.1 110804154 4209875 97932..98999 1 NC_008258.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 98999 murG 4209875 murG Shigella flexneri 5 str. 8401 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_687674.1 97932 D 373384 CDS YP_687675.1 110804155 4209876 99053..100528 1 NC_008258.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 100528 murC 4209876 murC Shigella flexneri 5 str. 8401 UDP-N-acetylmuramate--L-alanine ligase YP_687675.1 99053 D 373384 CDS YP_687676.1 110804156 4209877 100521..101441 1 NC_008258.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 101441 ddl 4209877 ddl Shigella flexneri 5 str. 8401 D-alanine--D-alanine ligase YP_687676.1 100521 D 373384 CDS YP_687677.1 110804157 4209878 101443..102273 1 NC_008258.1 involved in septum formation; cell division protein FtsQ 102273 ftsQ 4209878 ftsQ Shigella flexneri 5 str. 8401 cell division protein FtsQ YP_687677.1 101443 D 373384 CDS YP_687678.1 110804158 4209879 102363..103532 1 NC_008258.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 103532 ftsA 4209879 ftsA Shigella flexneri 5 str. 8401 cell division protein FtsA YP_687678.1 102363 D 373384 CDS YP_687679.1 110804159 4209880 103593..104744 1 NC_008258.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 104744 ftsZ 4209880 ftsZ Shigella flexneri 5 str. 8401 cell division protein FtsZ YP_687679.1 103593 D 373384 CDS YP_687680.1 110804160 4209881 104845..105762 1 NC_008258.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 105762 lpxC 4209881 lpxC Shigella flexneri 5 str. 8401 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_687680.1 104845 D 373384 CDS YP_687681.1 110804161 4209882 105840..106505 1 NC_008258.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 106505 yacA 4209882 yacA Shigella flexneri 5 str. 8401 SecA regulator SecM YP_687681.1 105840 D 373384 CDS YP_687682.1 110804162 4209883 106567..109272 1 NC_008258.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 109272 secA 4209883 secA Shigella flexneri 5 str. 8401 preprotein translocase subunit SecA YP_687682.1 106567 D 373384 CDS YP_687683.1 110804163 4207851 109332..109721 1 NC_008258.1 Code: LR; COG: COG0494; nucleoside triphosphate pyrophosphohydrolase 109721 mutT 4207851 mutT Shigella flexneri 5 str. 8401 nucleoside triphosphate pyrophosphohydrolase YP_687683.1 109332 D 373384 CDS YP_687684.1 110804164 4207852 complement(109821..110018) 1 NC_008258.1 Code: S; COG: COG3024; zinc-binding protein 110018 yacG 4207852 yacG Shigella flexneri 5 str. 8401 zinc-binding protein YP_687684.1 109821 R 373384 CDS YP_687685.1 110804165 4207853 complement(110028..110771) 1 NC_008258.1 Code: S; COG: COG4582; hypothetical protein 110771 yacF 4207853 yacF Shigella flexneri 5 str. 8401 hypothetical protein YP_687685.1 110028 R 373384 CDS YP_687686.1 110804166 4207854 complement(110771..111391) 1 NC_008258.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 111391 coaE 4207854 coaE Shigella flexneri 5 str. 8401 dephospho-CoA kinase YP_687686.1 110771 R 373384 CDS YP_687687.1 110804167 4207855 111616..112659 1 NC_008258.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 112659 guaC 4207855 guaC Shigella flexneri 5 str. 8401 guanosine 5'-monophosphate oxidoreductase YP_687687.1 111616 D 373384 CDS YP_687688.1 110804168 4207856 complement(112694..113896) 1 NC_008258.1 Code: NU; COG: COG1459; type IV pilin biogenesis protein 113896 hofC 4207856 hofC Shigella flexneri 5 str. 8401 type IV pilin biogenesis protein YP_687688.1 112694 R 373384 CDS YP_687689.1 110804169 4207858 complement(115043..115483) 1 NC_008258.1 Code: NU; COG: COG4969; major pilin subunit 115483 ppdD 4207858 ppdD Shigella flexneri 5 str. 8401 major pilin subunit YP_687689.1 115043 R 373384 CDS YP_687690.1 110804170 4207859 complement(115686..116579) 1 NC_008258.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 116579 nadC 4207859 nadC Shigella flexneri 5 str. 8401 quinolinate phosphoribosyltransferase YP_687690.1 115686 R 373384 CDS YP_687691.1 110804171 4207860 116667..117218 1 NC_008258.1 Code: V; COG: COG3023; N-acetyl-anhydromuranmyl-L-alanine amidase 117218 ampD 4207860 ampD Shigella flexneri 5 str. 8401 N-acetyl-anhydromuranmyl-L-alanine amidase YP_687691.1 116667 D 373384 CDS YP_687692.1 110804172 4207861 117215..118069 1 NC_008258.1 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 118069 ampE 4207861 ampE Shigella flexneri 5 str. 8401 regulatory protein AmpE YP_687692.1 117215 D 373384 CDS YP_687693.1 110804173 4207862 complement(118112..119485) 1 NC_008258.1 Code: E; COG: COG1113; aromatic amino acid transporter 119485 aroP 4207862 aroP Shigella flexneri 5 str. 8401 aromatic amino acid transporter YP_687693.1 118112 R 373384 CDS YP_687694.1 110804174 4207863 119993..120790 1 NC_008258.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 120790 pdhR 4207863 pdhR Shigella flexneri 5 str. 8401 transcriptional regulator PdhR YP_687694.1 119993 D 373384 CDS YP_687695.1 110804175 4207864 120951..123614 1 NC_008258.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 123614 aceE 4207864 aceE Shigella flexneri 5 str. 8401 pyruvate dehydrogenase subunit E1 YP_687695.1 120951 D 373384 CDS YP_687696.1 110804176 4207865 123629..125509 1 NC_008258.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 125509 aceF 4207865 aceF Shigella flexneri 5 str. 8401 dihydrolipoamide acetyltransferase YP_687696.1 123629 D 373384 CDS YP_687697.1 110804177 4207866 125831..127258 1 NC_008258.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 127258 lpdA 4207866 lpdA Shigella flexneri 5 str. 8401 dihydrolipoamide dehydrogenase YP_687697.1 125831 D 373384 CDS YP_687698.1 110804178 4207867 complement(127329..129176) 1 NC_008258.1 hypothetical protein 129176 yacH 4207867 yacH Shigella flexneri 5 str. 8401 hypothetical protein YP_687698.1 127329 R 373384 CDS YP_687699.1 110804179 4207868 129510..132134 1 NC_008258.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 132134 acnB 4207868 acnB Shigella flexneri 5 str. 8401 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_687699.1 129510 D 373384 CDS YP_687700.1 110804180 4207869 132261..132671 1 NC_008258.1 Code: S; COG: COG3112; hypothetical protein 132671 yacL 4207869 yacL Shigella flexneri 5 str. 8401 hypothetical protein YP_687700.1 132261 D 373384 CDS YP_687701.1 110804181 4210133 complement(132709..133503) 1 NC_008258.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 133503 speD 4210133 speD Shigella flexneri 5 str. 8401 S-adenosylmethionine decarboxylase YP_687701.1 132709 R 373384 CDS YP_687702.1 110804182 4210134 complement(133519..134385) 1 NC_008258.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 134385 speE 4210134 speE Shigella flexneri 5 str. 8401 spermidine synthase YP_687702.1 133519 R 373384 CDS YP_687703.1 110804184 4210136 complement(134491..135009) 1 NC_008258.1 hypothetical protein 135009 yacC 4210136 yacC Shigella flexneri 5 str. 8401 hypothetical protein YP_687703.1 134491 R 373384 CDS YP_687704.1 110804183 4210135 135004..136554 1 NC_008258.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 136554 yacK 4210135 yacK Shigella flexneri 5 str. 8401 multicopper oxidase YP_687704.1 135004 D 373384 CDS YP_687705.1 110804185 4210137 complement(136601..139009) 1 NC_008258.1 Code: G; COG: COG4993; glucose dehydrogenase 139009 gcd 4210137 gcd Shigella flexneri 5 str. 8401 glucose dehydrogenase YP_687705.1 136601 R 373384 CDS YP_687706.1 110804186 4210138 139134..139733 1 NC_008258.1 Code: F; COG: COG0634; hypoxanthine-guanine phosphoribosyltransferase 139733 hpt 4210138 hpt Shigella flexneri 5 str. 8401 hypoxanthine-guanine phosphoribosyltransferase YP_687706.1 139134 D 373384 CDS YP_687707.1 110804187 4210139 complement(139774..140436) 1 NC_008258.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 140436 yadF 4210139 yadF Shigella flexneri 5 str. 8401 carbonic anhydrase YP_687707.1 139774 R 373384 CDS YP_687708.1 110804188 4210140 140620..141471 1 NC_008258.1 Code: V; COG: COG1131; ABC transporter ATP-binding protein 141471 yadG 4210140 yadG Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_687708.1 140620 D 373384 CDS YP_687709.1 110804189 4210141 141468..142238 1 NC_008258.1 Code: V; COG: COG0842; hypothetical protein 142238 yadH 4210141 yadH Shigella flexneri 5 str. 8401 hypothetical protein YP_687709.1 141468 D 373384 CDS YP_687710.1 110804190 4210142 142847..144076 1 NC_008258.1 Code: G; COG: COG0726; hypothetical protein 144076 yadE 4210142 yadE Shigella flexneri 5 str. 8401 hypothetical protein YP_687710.1 142847 D 373384 CDS YP_687711.1 110804191 4210143 complement(144080..144460) 1 NC_008258.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 144460 panD 4210143 panD Shigella flexneri 5 str. 8401 aspartate alpha-decarboxylase YP_687711.1 144080 R 373384 CDS YP_687712.1 110804192 4210144 144734..145636 1 NC_008258.1 Code: S; COG: COG5464; hypothetical protein 145636 yadD 4210144 yadD Shigella flexneri 5 str. 8401 hypothetical protein YP_687712.1 144734 D 373384 CDS YP_687713.1 110804193 4210145 complement(145710..146561) 1 NC_008258.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 146561 panC 4210145 panC Shigella flexneri 5 str. 8401 pantoate--beta-alanine ligase YP_687713.1 145710 R 373384 CDS YP_687714.1 110804194 4210146 complement(146573..147367) 1 NC_008258.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 147367 panB 4210146 panB Shigella flexneri 5 str. 8401 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_687714.1 146573 R 373384 CDS YP_687715.1 110804195 4210147 complement(147480..147941) 1 NC_008258.1 hypothetical protein 147941 4210147 SFV_0125 Shigella flexneri 5 str. 8401 hypothetical protein YP_687715.1 147480 R 373384 CDS YP_687716.1 110804196 4210148 148055..148558 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 148558 insB 4210148 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_687716.1 148055 D 373384 CDS YP_687717.1 110804197 4210149 complement(148706..149185) 1 NC_008258.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 149185 folK 4210149 folK Shigella flexneri 5 str. 8401 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_687717.1 148706 R 373384 CDS YP_687718.1 110804198 4210150 complement(149182..150546) 1 NC_008258.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase 150546 pcnB 4210150 pcnB Shigella flexneri 5 str. 8401 poly(A) polymerase YP_687718.1 149182 R 373384 CDS YP_687719.2 162139363 4210151 complement(150639..151535) 1 NC_008258.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 151535 yadB 4210151 yadB Shigella flexneri 5 str. 8401 glutamyl-Q tRNA(Asp) synthetase YP_687719.2 150639 R 373384 CDS YP_687720.1 110804200 4210152 complement(151602..152057) 1 NC_008258.1 Code: T; COG: COG1734; RNA polymerase-binding transcription factor 152057 dksA 4210152 dksA Shigella flexneri 5 str. 8401 RNA polymerase-binding transcription factor YP_687720.1 151602 R 373384 CDS YP_687721.1 110804201 4209045 complement(152235..152939) 1 NC_008258.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 152939 sfsA 4209045 sfsA Shigella flexneri 5 str. 8401 sugar fermentation stimulation protein A YP_687721.1 152235 R 373384 CDS YP_687722.1 110804203 4209047 complement(152954..153697) 1 NC_008258.1 Code: J; COG: COG1514; hypothetical protein 153697 yadP 4209047 yadP Shigella flexneri 5 str. 8401 hypothetical protein YP_687722.1 152954 R 373384 CDS YP_687723.1 110804202 4209046 153558..155987 1 NC_008258.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 155987 hrpB 4209046 hrpB Shigella flexneri 5 str. 8401 ATP-dependent RNA helicase HrpB YP_687723.1 153558 D 373384 CDS YP_687724.1 110804204 4209048 156183..158717 1 NC_008258.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 158717 mrcB 4209048 mrcB Shigella flexneri 5 str. 8401 penicillin-binding protein 1b YP_687724.1 156183 D 373384 CDS YP_687725.1 110804205 4209049 159015..161180 1 NC_008258.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 161180 fhuA 4209049 fhuA Shigella flexneri 5 str. 8401 ferrichrome outer membrane transporter YP_687725.1 159015 D 373384 CDS YP_687726.1 110804206 4209050 161189..162028 1 NC_008258.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 162028 fhuC 4209050 fhuC Shigella flexneri 5 str. 8401 iron-hydroxamate transporter ATP-binding subunit YP_687726.1 161189 D 373384 CDS YP_687727.1 110804207 4209051 162028..162918 1 NC_008258.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 162918 fhuD 4209051 fhuD Shigella flexneri 5 str. 8401 iron-hydroxamate transporter substrate-binding subunit YP_687727.1 162028 D 373384 CDS YP_687728.1 110804208 4209052 162915..164897 1 NC_008258.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 164897 fhuB 4209052 fhuB Shigella flexneri 5 str. 8401 iron-hydroxamate transporter permease subunit YP_687728.1 162915 D 373384 CDS YP_687729.1 110804209 4209053 complement(164932..166212) 1 NC_008258.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 166212 hemL 4209053 hemL Shigella flexneri 5 str. 8401 glutamate-1-semialdehyde aminotransferase YP_687729.1 164932 R 373384 CDS YP_687730.1 110804210 4209054 166437..167858 1 NC_008258.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 167858 yadQ 4209054 yadQ Shigella flexneri 5 str. 8401 chloride channel protein YP_687730.1 166437 D 373384 CDS YP_687731.1 110804211 4209055 167940..168284 1 NC_008258.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 168284 yadR 4209055 yadR Shigella flexneri 5 str. 8401 iron-sulfur cluster insertion protein ErpA YP_687731.1 167940 D 373384 CDS YP_687732.1 110804212 4209056 complement(168331..168954) 1 NC_008258.1 Code: S; COG: COG2860; hypothetical protein 168954 yadS 4209056 yadS Shigella flexneri 5 str. 8401 hypothetical protein YP_687732.1 168331 R 373384 CDS YP_687733.1 110804213 4209057 complement(168992..169819) 1 NC_008258.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 169819 yadT 4209057 yadT Shigella flexneri 5 str. 8401 vitamin B12-transporter protein BtuF YP_687733.1 168992 R 373384 CDS YP_687734.1 110804214 4209058 complement(169785..170483) 1 NC_008258.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 170483 pfs 4209058 pfs Shigella flexneri 5 str. 8401 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_687734.1 169785 R 373384 CDS YP_687735.1 110804215 4209059 170567..172084 1 NC_008258.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 172084 dgt 4209059 dgt Shigella flexneri 5 str. 8401 deoxyguanosinetriphosphate triphosphohydrolase YP_687735.1 170567 D 373384 CDS YP_687736.1 110804216 4209060 172214..173638 1 NC_008258.1 heat shock protein HtrA; protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 173638 htrA 4209060 htrA Shigella flexneri 5 str. 8401 serine endoprotease YP_687736.1 172214 D 373384 CDS YP_687737.1 110804217 4209062 complement(175026..175412) 1 NC_008258.1 hypothetical protein 175412 yaeH 4209062 yaeH Shigella flexneri 5 str. 8401 hypothetical protein YP_687737.1 175026 R 373384 CDS YP_687738.1 110804218 4209063 complement(175726..176550) 1 NC_008258.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 176550 dapD 4209063 dapD Shigella flexneri 5 str. 8401 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_687738.1 175726 R 373384 CDS YP_687739.1 110804219 4208382 complement(176581..179253) 1 NC_008258.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 179253 glnD 4208382 glnD Shigella flexneri 5 str. 8401 PII uridylyl-transferase YP_687739.1 176581 R 373384 CDS YP_687740.2 162139362 4208383 complement(179315..180109) 1 NC_008258.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 180109 map 4208383 map Shigella flexneri 5 str. 8401 methionine aminopeptidase YP_687740.2 179315 R 373384 CDS YP_687741.2 394894203 4208384 180477..181202 1 NC_008258.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 181202 rpsB 4208384 rpsB Shigella flexneri 5 str. 8401 30S ribosomal protein S2 YP_687741.2 180477 D 373384 CDS YP_687742.1 110804222 4208385 181460..182311 1 NC_008258.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 182311 tsf 4208385 tsf Shigella flexneri 5 str. 8401 elongation factor Ts YP_687742.1 181460 D 373384 CDS YP_687743.1 110804223 4208386 182458..183183 1 NC_008258.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 183183 pyrH 4208386 pyrH Shigella flexneri 5 str. 8401 uridylate kinase YP_687743.1 182458 D 373384 CDS YP_687744.1 110804224 4208387 183475..184032 1 NC_008258.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 184032 frr 4208387 frr Shigella flexneri 5 str. 8401 ribosome recycling factor YP_687744.1 183475 D 373384 CDS YP_687745.1 110804225 4208388 184124..185320 1 NC_008258.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 185320 yaeM 4208388 yaeM Shigella flexneri 5 str. 8401 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_687745.1 184124 D 373384 CDS YP_687746.1 110804226 4208389 185509..186267 1 NC_008258.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 186267 yaeS 4208389 yaeS Shigella flexneri 5 str. 8401 undecaprenyl pyrophosphate synthase YP_687746.1 185509 D 373384 CDS YP_687747.1 110804227 4208390 186310..187137 1 NC_008258.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 187137 cdsA 4208390 cdsA Shigella flexneri 5 str. 8401 CDP-diglyceride synthase YP_687747.1 186310 D 373384 CDS YP_687748.1 110804228 4208391 187149..188501 1 NC_008258.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 188501 yaeL 4208391 yaeL Shigella flexneri 5 str. 8401 zinc metallopeptidase RseP YP_687748.1 187149 D 373384 CDS YP_687749.1 110804229 4208392 188531..190963 1 NC_008258.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 190963 yaeT 4208392 yaeT Shigella flexneri 5 str. 8401 outer membrane protein assembly factor YaeT YP_687749.1 188531 D 373384 CDS YP_687750.1 110804230 4208393 191085..191570 1 NC_008258.1 Code: M; COG: COG2825; periplasmic chaperone 191570 hlpA 4208393 hlpA Shigella flexneri 5 str. 8401 periplasmic chaperone YP_687750.1 191085 D 373384 CDS YP_687751.1 110804231 4208394 191610..192599 1 NC_008258.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 192599 lpxD 4208394 lpxD Shigella flexneri 5 str. 8401 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_687751.1 191610 D 373384 CDS YP_687752.1 110804232 4208395 192611..193159 1 NC_008258.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 193159 fabZ 4208395 fabZ Shigella flexneri 5 str. 8401 (3R)-hydroxymyristoyl-ACP dehydratase YP_687752.1 192611 D 373384 CDS YP_687753.1 110804233 4208396 193163..193951 1 NC_008258.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 193951 lpxA 4208396 lpxA Shigella flexneri 5 str. 8401 UDP-N-acetylglucosamine acyltransferase YP_687753.1 193163 D 373384 CDS YP_687754.1 110804234 4208397 193951..195099 1 NC_008258.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 195099 lpxB 4208397 lpxB Shigella flexneri 5 str. 8401 lipid-A-disaccharide synthase YP_687754.1 193951 D 373384 CDS YP_687755.1 110804235 4208398 195096..195692 1 NC_008258.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 195692 rnhB 4208398 rnhB Shigella flexneri 5 str. 8401 ribonuclease HII YP_687755.1 195096 D 373384 CDS YP_687756.1 110804236 4208399 195828..199211 1 NC_008258.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 199211 dnaE 4208399 dnaE Shigella flexneri 5 str. 8401 DNA polymerase III subunit alpha YP_687756.1 195828 D 373384 CDS YP_687757.1 110804237 4208400 199224..200183 1 NC_008258.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 200183 accA 4208400 accA Shigella flexneri 5 str. 8401 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_687757.1 199224 D 373384 CDS YP_687758.1 110804238 4208401 200282..202423 1 NC_008258.1 Code: E; COG: COG1982; lysine decarboxylase 2 202423 ldcC 4208401 ldcC Shigella flexneri 5 str. 8401 lysine decarboxylase 2 YP_687758.1 200282 D 373384 CDS YP_687759.1 110804239 4209903 202480..202869 1 NC_008258.1 Code: E; COG: COG0346; hypothetical protein 202869 yaeR 4209903 yaeR Shigella flexneri 5 str. 8401 hypothetical protein YP_687759.1 202480 D 373384 CDS YP_687760.1 110804240 4209905 complement(204282..204542) 1 NC_008258.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 204542 yaeO 4209905 yaeO Shigella flexneri 5 str. 8401 Rho-binding antiterminator YP_687760.1 204282 R 373384 CDS YP_687761.1 110804241 4209906 complement(204529..204729) 1 NC_008258.1 hypothetical protein 204729 yaeP 4209906 yaeP Shigella flexneri 5 str. 8401 hypothetical protein YP_687761.1 204529 R 373384 CDS YP_687762.1 110804242 4209907 204895..205440 1 NC_008258.1 Code: S; COG: COG4681; hypothetical protein 205440 yaeQ 4209907 yaeQ Shigella flexneri 5 str. 8401 hypothetical protein YP_687762.1 204895 D 373384 CDS YP_687763.1 110804243 4209908 205437..205859 1 NC_008258.1 Code: J; COG: COG1186; peptidyl-tRNA hydrolase domain-containing protein 205859 yaeJ 4209908 yaeJ Shigella flexneri 5 str. 8401 peptidyl-tRNA hydrolase domain-containing protein YP_687763.1 205437 D 373384 CDS YP_687764.1 110804244 4209909 205873..206583 1 NC_008258.1 Code: MP; COG: COG3015; lipoprotein involved with copper homeostasis and adhesion 206583 cutF 4209909 cutF Shigella flexneri 5 str. 8401 lipoprotein involved with copper homeostasis and adhesion YP_687764.1 205873 D 373384 CDS YP_687765.1 110804245 4209910 complement(206738..207571) 1 NC_008258.1 hypothetical protein 207571 yaeF 4209910 yaeF Shigella flexneri 5 str. 8401 hypothetical protein YP_687765.1 206738 R 373384 CDS YP_687766.2 162139361 4209911 complement(207615..209333) 1 NC_008258.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 209333 proS 4209911 proS Shigella flexneri 5 str. 8401 prolyl-tRNA synthetase YP_687766.2 207615 R 373384 CDS YP_687767.1 110804247 4209912 complement(209444..210151) 1 NC_008258.1 Code: S; COG: COG1720; hypothetical protein 210151 yaeB 4209912 yaeB Shigella flexneri 5 str. 8401 hypothetical protein YP_687767.1 209444 R 373384 CDS YP_687768.1 110804248 4209913 complement(210148..210552) 1 NC_008258.1 outer membrane lipoprotein 210552 rcsF 4209913 rcsF Shigella flexneri 5 str. 8401 outer membrane lipoprotein YP_687768.1 210148 R 373384 CDS YP_687769.1 110804249 4209914 complement(210670..211485) 1 NC_008258.1 Code: P; COG: COG1464; DL-methionine transporter substrate-binding subunit 211485 metQ 4209914 metQ Shigella flexneri 5 str. 8401 DL-methionine transporter substrate-binding subunit YP_687769.1 210670 R 373384 CDS YP_687770.1 110804250 4209915 complement(211525..212163) 1 NC_008258.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease subunit 212163 yaeE 4209915 yaeE Shigella flexneri 5 str. 8401 DL-methionine transporter permease subunit YP_687770.1 211525 R 373384 CDS YP_687771.1 110804251 4209916 complement(212171..213202) 1 NC_008258.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 213202 metN 4209916 metN Shigella flexneri 5 str. 8401 DL-methionine transporter ATP-binding subunit YP_687771.1 212171 R 373384 CDS YP_687772.1 110804252 4209917 213390..213965 1 NC_008258.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 213965 yaeD 4209917 yaeD Shigella flexneri 5 str. 8401 D,D-heptose 1,7-bisphosphate phosphatase YP_687772.1 213390 D 373384 CDS YP_687773.1 110804253 4208058 219633..220436 1 NC_008258.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 220436 dkgB 4208058 dkgB Shigella flexneri 5 str. 8401 2,5-diketo-D-gluconate reductase B YP_687773.1 219633 D 373384 CDS YP_687774.1 110804254 4208059 complement(220475..221821) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 221821 4208059 SFV_0191 Shigella flexneri 5 str. 8401 IS4 orf YP_687774.1 220475 R 373384 CDS YP_687775.1 110804255 4208060 complement(221871..222785) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 222785 yafC 4208060 yafC Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_687775.1 221871 R 373384 CDS YP_687776.1 110804256 4208061 223026..223826 1 NC_008258.1 Code: S; COG: COG3021; hypothetical protein 223826 yafD 4208061 yafD Shigella flexneri 5 str. 8401 hypothetical protein YP_687776.1 223026 D 373384 CDS YP_687777.1 110804257 4208062 223904..224674 1 NC_008258.1 Code: QR; COG: COG0500; biotin synthesis protein 224674 yafE 4208062 yafE Shigella flexneri 5 str. 8401 biotin synthesis protein YP_687777.1 223904 D 373384 CDS YP_687778.1 110804258 4208063 complement(224722..226080) 1 NC_008258.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 226080 mltD 4208063 mltD Shigella flexneri 5 str. 8401 membrane-bound lytic murein transglycosylase D YP_687778.1 224722 R 373384 CDS YP_687779.1 110804259 4208064 complement(226152..226907) 1 NC_008258.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 226907 gloB 4208064 gloB Shigella flexneri 5 str. 8401 hydroxyacylglutathione hydrolase YP_687779.1 226152 R 373384 CDS YP_687780.1 110804260 4208065 226941..227663 1 NC_008258.1 Code: QR; COG: COG0500; hypothetical protein 227663 yafS 4208065 yafS Shigella flexneri 5 str. 8401 hypothetical protein YP_687780.1 226941 D 373384 CDS YP_687781.1 110804262 4208067 complement(227660..228238) 1 NC_008258.1 degrades RNA of DNA-RNA hybrids, participates in DNA replication; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 228238 rnhA 4208067 rnhA Shigella flexneri 5 str. 8401 ribonuclease H YP_687781.1 227660 R 373384 CDS YP_687782.1 110804261 4208066 228183..228923 1 NC_008258.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 228923 dnaQ 4208066 dnaQ Shigella flexneri 5 str. 8401 DNA polymerase III subunit epsilon YP_687782.1 228183 D 373384 CDS YP_687783.1 110804263 4208069 complement(229263..230309) 1 NC_008258.1 Code: S; COG: COG3515; cytoplasmic protein 230309 safA 4208069 safA Shigella flexneri 5 str. 8401 cytoplasmic protein YP_687783.1 229263 R 373384 CDS YP_687784.1 110804264 4208070 complement(230320..230832) 1 NC_008258.1 hypothetical protein 230832 4208070 SFV_0202 Shigella flexneri 5 str. 8401 hypothetical protein YP_687784.1 230320 R 373384 CDS YP_687785.1 110804265 4211030 complement(230987..231304) 1 NC_008258.1 periplasmic chaperone of fimbral assembly machinery 231304 safB 4211030 safB Shigella flexneri 5 str. 8401 periplasmic chaperone of fimbral assembly machinery YP_687785.1 230987 R 373384 CDS YP_687786.1 110804266 4211032 complement(233200..233694) 1 NC_008258.1 Code: S; COG: COG3518; cytoplasmic protein 233694 4211032 SFV_0205 Shigella flexneri 5 str. 8401 cytoplasmic protein YP_687786.1 233200 R 373384 CDS YP_687787.1 110804267 4211033 complement(233889..234521) 1 NC_008258.1 Code: R; COG: COG4455; cytoplasmic protein 234521 sat1 4211033 sat1 Shigella flexneri 5 str. 8401 cytoplasmic protein YP_687787.1 233889 R 373384 CDS YP_687788.1 110804268 4211034 complement(234508..234885) 1 NC_008258.1 cytoplasmic protein 234885 sat2 4211034 sat2 Shigella flexneri 5 str. 8401 cytoplasmic protein YP_687788.1 234508 R 373384 CDS YP_687789.1 110804269 4211035 235520..235885 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 235885 4211035 SFV_0208 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_687789.1 235520 D 373384 CDS YP_687790.1 110804270 4211036 235909..236748 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 236748 4211036 SFV_0209 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_687790.1 235909 D 373384 CDS YP_687791.1 110804271 4211037 complement(236805..237323) 1 NC_008258.1 hypothetical protein 237323 4211037 SFV_0210 Shigella flexneri 5 str. 8401 hypothetical protein YP_687791.1 236805 R 373384 CDS YP_687792.1 110804272 4211038 complement(237311..237778) 1 NC_008258.1 endopeptidase 237778 4211038 SFV_0211 Shigella flexneri 5 str. 8401 endopeptidase YP_687792.1 237311 R 373384 CDS YP_687793.1 110804273 4211039 complement(237775..238308) 1 NC_008258.1 Code: R; COG: COG3772; lysozyme 238308 4211039 SFV_0212 Shigella flexneri 5 str. 8401 lysozyme YP_687793.1 237775 R 373384 CDS YP_687794.1 110804274 4211040 complement(238374..238934) 1 NC_008258.1 hypothetical protein 238934 4211040 SFV_0213 Shigella flexneri 5 str. 8401 hypothetical protein YP_687794.1 238374 R 373384 CDS YP_687795.1 110804275 4211041 complement(239008..239223) 1 NC_008258.1 hypothetical protein 239223 4211041 SFV_0214 Shigella flexneri 5 str. 8401 hypothetical protein YP_687795.1 239008 R 373384 CDS YP_687796.1 110804276 4211042 complement(239978..241117) 1 NC_008258.1 hypothetical protein 241117 4211042 SFV_0215 Shigella flexneri 5 str. 8401 hypothetical protein YP_687796.1 239978 R 373384 CDS YP_687797.1 110804277 4211043 complement(241219..241629) 1 NC_008258.1 hypothetical protein 241629 4211043 SFV_0216 Shigella flexneri 5 str. 8401 hypothetical protein YP_687797.1 241219 R 373384 CDS YP_687798.1 110804278 4211044 242362..242664 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 242664 4211044 SFV_0217 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_687798.1 242362 D 373384 CDS YP_687799.1 110804279 4211045 242965..243531 1 NC_008258.1 IS911 ORF2 243531 4211045 SFV_0218 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_687799.1 242965 D 373384 CDS YP_687800.1 110804280 4211046 243525..244589 1 NC_008258.1 Code: R; COG: COG5565; terminase large subunit 244589 4211046 SFV_0219 Shigella flexneri 5 str. 8401 terminase large subunit YP_687800.1 243525 D 373384 CDS YP_687801.1 110804281 4211047 244590..246755 1 NC_008258.1 packaging glycoprotein 246755 4211047 SFV_0220 Shigella flexneri 5 str. 8401 packaging glycoprotein YP_687801.1 244590 D 373384 CDS YP_687802.1 110804282 4211048 246769..247680 1 NC_008258.1 scaffolding protein 247680 4211048 SFV_0221 Shigella flexneri 5 str. 8401 scaffolding protein YP_687802.1 246769 D 373384 CDS YP_687803.1 110804283 4211082 247680..248975 1 NC_008258.1 coat protein 248975 4211082 SFV_0222 Shigella flexneri 5 str. 8401 coat protein YP_687803.1 247680 D 373384 CDS YP_687804.1 110804284 4211083 248972..249244 1 NC_008258.1 hypothetical protein 249244 4211083 SFV_0223 Shigella flexneri 5 str. 8401 hypothetical protein YP_687804.1 248972 D 373384 CDS YP_687805.1 110804285 4211084 249222..249722 1 NC_008258.1 DNA stabilization protein 249722 4211084 SFV_0224 Shigella flexneri 5 str. 8401 DNA stabilization protein YP_687805.1 249222 D 373384 CDS YP_687806.1 110804286 4211085 249723..251141 1 NC_008258.1 packaged DNA stabilization protein 251141 4211085 SFV_0225 Shigella flexneri 5 str. 8401 packaged DNA stabilization protein YP_687806.1 249723 D 373384 CDS YP_687807.1 110804287 4211086 251141..251989 1 NC_008258.1 packaged DNA stabilization protein 251989 4211086 SFV_0226 Shigella flexneri 5 str. 8401 packaged DNA stabilization protein YP_687807.1 251141 D 373384 CDS YP_687808.1 110804288 4211087 251989..252444 1 NC_008258.1 head assembly protein 252444 4211087 SFV_0227 Shigella flexneri 5 str. 8401 head assembly protein YP_687808.1 251989 D 373384 CDS YP_687809.1 110804289 4211088 252447..253139 1 NC_008258.1 DNA transfer protein 253139 4211088 SFV_0228 Shigella flexneri 5 str. 8401 DNA transfer protein YP_687809.1 252447 D 373384 CDS YP_687810.1 110804290 4211089 253149..254480 1 NC_008258.1 prophage DNA injection protein 254480 4211089 SFV_0229 Shigella flexneri 5 str. 8401 prophage DNA injection protein YP_687810.1 253149 D 373384 CDS YP_687811.1 110804291 4211090 254481..256211 1 NC_008258.1 DNA transfer protein 256211 4211090 SFV_0230 Shigella flexneri 5 str. 8401 DNA transfer protein YP_687811.1 254481 D 373384 CDS YP_687812.1 110804292 4211091 256337..256663 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 256663 4211091 SFV_0231 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_687812.1 256337 D 373384 CDS YP_687813.1 110804293 4211092 256663..257550 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 257550 4211092 SFV_0232 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_687813.1 256663 D 373384 CDS YP_687814.1 110804294 4211093 complement(257596..258033) 1 NC_008258.1 IS600 ORF2 258033 4211093 SFV_0233 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_687814.1 257596 R 373384 CDS YP_687815.1 110804295 4211094 complement(258069..258371) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 258371 4211094 SFV_0234 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_687815.1 258069 R 373384 CDS YP_687816.1 110804296 4211095 258523..258855 1 NC_008258.1 terminase 258855 4211095 SFV_0235 Shigella flexneri 5 str. 8401 terminase YP_687816.1 258523 D 373384 CDS YP_687817.1 110804297 4211096 258867..259049 1 NC_008258.1 hypothetical protein 259049 ymfR 4211096 ymfR Shigella flexneri 5 str. 8401 hypothetical protein YP_687817.1 258867 D 373384 CDS YP_687818.1 110804298 4211097 259049..260290 1 NC_008258.1 portal protein 260290 4211097 SFV_0237 Shigella flexneri 5 str. 8401 portal protein YP_687818.1 259049 D 373384 CDS YP_687819.1 110804299 4211098 260268..260918 1 NC_008258.1 Code: R; COG: COG3740; prohead protease 260918 4211098 SFV_0238 Shigella flexneri 5 str. 8401 prohead protease YP_687819.1 260268 D 373384 CDS YP_687820.1 110804300 4211099 260933..262138 1 NC_008258.1 Code: R; COG: COG4653; bacteriophage protein 262138 4211099 SFV_0239 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687820.1 260933 D 373384 CDS YP_687821.1 110804301 4211100 262188..262388 1 NC_008258.1 bacteriophage protein 262388 4211100 SFV_0240 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687821.1 262188 D 373384 CDS YP_687822.1 110804302 4211101 262391..262714 1 NC_008258.1 bacteriophage protein 262714 4211101 SFV_0241 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687822.1 262391 D 373384 CDS YP_687823.1 110804303 4210153 262711..263121 1 NC_008258.1 bacteriophage protein 263121 4210153 SFV_0242 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687823.1 262711 D 373384 CDS YP_687824.1 110804304 4210154 263096..263602 1 NC_008258.1 bacteriophage protein 263602 4210154 SFV_0243 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687824.1 263096 D 373384 CDS YP_687825.1 110804305 4210155 263599..264159 1 NC_008258.1 bacteriophage protein 264159 4210155 SFV_0244 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687825.1 263599 D 373384 CDS YP_687826.1 110804306 4210156 264322..265818 1 NC_008258.1 Code: R; COG: COG4386; sheath protein 265818 4210156 SFV_0245 Shigella flexneri 5 str. 8401 sheath protein YP_687826.1 264322 D 373384 CDS YP_687827.1 110804307 4210157 265818..266174 1 NC_008258.1 hypothetical protein 266174 4210157 SFV_0246 Shigella flexneri 5 str. 8401 hypothetical protein YP_687827.1 265818 D 373384 CDS YP_687828.1 110804308 4210158 266174..266443 1 NC_008258.1 bacteriophage protein 266443 4210158 SFV_0247 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687828.1 266174 D 373384 CDS YP_687829.1 110804309 4210159 266585..268420 1 NC_008258.1 tail protein 268420 4210159 SFV_0248 Shigella flexneri 5 str. 8401 tail protein YP_687829.1 266585 D 373384 CDS YP_687830.1 110804310 4210160 268481..269809 1 NC_008258.1 tail/DNA circulation protein 269809 4210160 SFV_0249 Shigella flexneri 5 str. 8401 tail/DNA circulation protein YP_687830.1 268481 D 373384 CDS YP_687831.1 110804311 4210161 269806..270885 1 NC_008258.1 Code: R; COG: COG4379; tail protein 270885 4210161 SFV_0250 Shigella flexneri 5 str. 8401 tail protein YP_687831.1 269806 D 373384 CDS YP_687832.1 110804312 4210162 270885..271433 1 NC_008258.1 tail protein 271433 4210162 SFV_0251 Shigella flexneri 5 str. 8401 tail protein YP_687832.1 270885 D 373384 CDS YP_687833.1 110804313 4210163 271433..271858 1 NC_008258.1 Code: S; COG: COG4381; tail protein 271858 4210163 SFV_0252 Shigella flexneri 5 str. 8401 tail protein YP_687833.1 271433 D 373384 CDS YP_687834.1 110804314 4210164 271845..272903 1 NC_008258.1 Code: S; COG: COG3299; hypothetical protein 272903 4210164 SFV_0253 Shigella flexneri 5 str. 8401 hypothetical protein YP_687834.1 271845 D 373384 CDS YP_687835.1 110804315 4210165 272894..273478 1 NC_008258.1 Code: S; COG: COG3778; hypothetical protein 273478 4210165 SFV_0254 Shigella flexneri 5 str. 8401 hypothetical protein YP_687835.1 272894 D 373384 CDS YP_687836.1 110804316 4210166 274041..274544 1 NC_008258.1 phage tail fiber protein 274544 4210166 SFV_0255 Shigella flexneri 5 str. 8401 phage tail fiber protein YP_687836.1 274041 D 373384 CDS YP_687837.1 110804317 4210167 complement(274667..275920) 1 NC_008258.1 serotype-specific glucosyl transferase 275920 gtrV 4210167 gtrV Shigella flexneri 5 str. 8401 serotype-specific glucosyl transferase YP_687837.1 274667 R 373384 CDS YP_687838.1 110804318 4210168 complement(275917..276840) 1 NC_008258.1 Code: M; COG: COG0463; bactoprenol glucosyl transferase 276840 gtrB 4210168 gtrB Shigella flexneri 5 str. 8401 bactoprenol glucosyl transferase YP_687838.1 275917 R 373384 CDS YP_687839.1 110804319 4210169 complement(276837..277199) 1 NC_008258.1 bactoprenol-linked glucose translocase 277199 gtra 4210169 gtra Shigella flexneri 5 str. 8401 bactoprenol-linked glucose translocase YP_687839.1 276837 R 373384 CDS YP_687840.1 110804320 4210170 complement(277461..278621) 1 NC_008258.1 Code: L; COG: COG0582; integrase 278621 4210170 SFV_0259 Shigella flexneri 5 str. 8401 integrase YP_687840.1 277461 R 373384 CDS YP_687841.1 110804321 4210171 complement(279662..280501) 1 NC_008258.1 bacteriophage protein 280501 4210171 SFV_0260 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687841.1 279662 R 373384 CDS YP_687842.1 110804322 4210172 complement(280503..281159) 1 NC_008258.1 bacteriophage protein 281159 4210172 SFV_0261 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687842.1 280503 R 373384 CDS YP_687843.1 110804323 4210173 complement(281146..281463) 1 NC_008258.1 hypothetical protein 281463 4210173 SFV_0262 Shigella flexneri 5 str. 8401 hypothetical protein YP_687843.1 281146 R 373384 CDS YP_687844.1 110804324 4210174 complement(281566..281922) 1 NC_008258.1 bacteriophage protein 281922 4210174 SFV_0263 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687844.1 281566 R 373384 CDS YP_687845.1 110804325 4210175 complement(282426..282908) 1 NC_008258.1 hypothetical protein 282908 4210175 SFV_0264 Shigella flexneri 5 str. 8401 hypothetical protein YP_687845.1 282426 R 373384 CDS YP_687846.1 110804326 4210176 complement(282892..283794) 1 NC_008258.1 phage-related DNA recombination protein 283794 4210176 SFV_0265 Shigella flexneri 5 str. 8401 phage-related DNA recombination protein YP_687846.1 282892 R 373384 CDS YP_687847.1 110804327 4210177 complement(283791..284099) 1 NC_008258.1 hypothetical protein 284099 4210177 SFV_0266 Shigella flexneri 5 str. 8401 hypothetical protein YP_687847.1 283791 R 373384 CDS YP_687848.1 110804328 4210178 complement(284251..284493) 1 NC_008258.1 IS1 encoded protein 284493 4210178 SFV_0267 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_687848.1 284251 R 373384 CDS YP_687849.1 110804329 4210179 284568..285071 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 285071 insB 4210179 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_687849.1 284568 D 373384 CDS YP_687850.1 110804330 4210180 complement(286308..286631) 1 NC_008258.1 bacteriophage protein 286631 4210180 SFV_0269 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687850.1 286308 R 373384 CDS YP_687851.1 110804331 4210181 complement(287337..287969) 1 NC_008258.1 Code: KT; COG: COG1974; prophage repressor CI 287969 4210181 SFV_0270 Shigella flexneri 5 str. 8401 prophage repressor CI YP_687851.1 287337 R 373384 CDS YP_687852.1 110804332 4210182 complement(288369..289715) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 289715 4210182 SFV_0271 Shigella flexneri 5 str. 8401 IS4 orf YP_687852.1 288369 R 373384 CDS YP_687853.1 110804333 4210183 290308..291132 1 NC_008258.1 replication protein O 291132 4210183 SFV_0272 Shigella flexneri 5 str. 8401 replication protein O YP_687853.1 290308 D 373384 CDS YP_687854.1 110804334 4210184 291122..292558 1 NC_008258.1 Code: L; COG: COG0305; replication protein P 292558 4210184 SFV_0273 Shigella flexneri 5 str. 8401 replication protein P YP_687854.1 291122 D 373384 CDS YP_687855.1 110804335 4210185 293591..293821 1 NC_008258.1 hypothetical protein 293821 4210185 SFV_0274 Shigella flexneri 5 str. 8401 hypothetical protein YP_687855.1 293591 D 373384 CDS YP_687856.1 110804336 4210186 293814..294536 1 NC_008258.1 DNA-binding protein Roi of bacteriophage BP-933W 294536 4210186 SFV_0275 Shigella flexneri 5 str. 8401 DNA-binding protein Roi of bacteriophage BP-933W YP_687856.1 293814 D 373384 CDS YP_687857.1 110804337 4210187 294823..295185 1 NC_008258.1 Code: L; COG: COG4570; crossover junction endodeoxyribonuclease 295185 4210187 SFV_0276 Shigella flexneri 5 str. 8401 crossover junction endodeoxyribonuclease YP_687857.1 294823 D 373384 CDS YP_687858.1 110804338 4210188 295367..295990 1 NC_008258.1 antitermination protein 295990 4210188 SFV_0277 Shigella flexneri 5 str. 8401 antitermination protein YP_687858.1 295367 D 373384 CDS YP_687859.1 110804339 4210189 296659..296982 1 NC_008258.1 cell lysis protein 296982 4210189 SFV_0278 Shigella flexneri 5 str. 8401 cell lysis protein YP_687859.1 296659 D 373384 CDS YP_687860.1 110804340 4210190 296966..297292 1 NC_008258.1 Code: G; COG: COG4678; endolysin 297292 4210190 SFV_0279 Shigella flexneri 5 str. 8401 endolysin YP_687860.1 296966 D 373384 CDS YP_687861.1 110804341 4210191 297440..297877 1 NC_008258.1 endopeptidase 297877 4210191 SFV_0280 Shigella flexneri 5 str. 8401 endopeptidase YP_687861.1 297440 D 373384 CDS YP_687862.1 110804342 4210192 298079..298600 1 NC_008258.1 bacteriophage protein 298600 4210192 SFV_0281 Shigella flexneri 5 str. 8401 bacteriophage protein YP_687862.1 298079 D 373384 CDS YP_687863.1 110804343 4210193 299117..299419 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 299419 4210193 SFV_0282 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_687863.1 299117 D 373384 CDS YP_687864.1 110804344 4210194 299560..300273 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 300273 4210194 SFV_0283 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_687864.1 299560 D 373384 CDS YP_687865.1 110804345 4210196 complement(300880..302133) 1 NC_008258.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 302133 proA 4210196 proA Shigella flexneri 5 str. 8401 gamma-glutamyl phosphate reductase YP_687865.1 300880 R 373384 CDS YP_687866.1 110804346 4210197 complement(302145..303248) 1 NC_008258.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 303248 proB 4210197 proB Shigella flexneri 5 str. 8401 gamma-glutamyl kinase YP_687866.1 302145 R 373384 CDS YP_687867.1 110804347 4210198 complement(303439..303942) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 303942 insB 4210198 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_687867.1 303439 R 373384 CDS YP_687868.1 110804348 4210199 304017..304211 1 NC_008258.1 IS1 encoded protein 304211 4210199 SFV_0288 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_687868.1 304017 D 373384 CDS YP_687869.1 110804349 4210200 304312..305367 1 NC_008258.1 Code: M; COG: COG3203; outer membrane phosphoporin protein E 305367 phoE 4210200 phoE Shigella flexneri 5 str. 8401 outer membrane phosphoporin protein E YP_687869.1 304312 D 373384 CDS YP_687870.1 110804350 4210201 complement(305406..305807) 1 NC_008258.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 305807 crl 4210201 crl Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator Crl YP_687870.1 305406 R 373384 CDS YP_687871.1 110804351 4210202 complement(305865..307109) 1 NC_008258.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 307109 frsA 4210202 frsA Shigella flexneri 5 str. 8401 fermentation/respiration switch protein YP_687871.1 305865 R 373384 CDS YP_687872.1 110804352 4210203 complement(307201..307659) 1 NC_008258.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 307659 gpt 4210203 gpt Shigella flexneri 5 str. 8401 xanthine-guanine phosphoribosyltransferase YP_687872.1 307201 R 373384 CDS YP_687873.1 110804353 4210204 307921..309378 1 NC_008258.1 Code: E; COG: COG2195; aminoacyl-histidine dipeptidase 309378 pepD 4210204 pepD Shigella flexneri 5 str. 8401 aminoacyl-histidine dipeptidase YP_687873.1 307921 D 373384 CDS YP_687874.1 110804354 4210206 complement(310111..311181) 1 NC_008258.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 311181 4210206 SFV_0295 Shigella flexneri 5 str. 8401 hypothetical protein YP_687874.1 310111 R 373384 CDS YP_687875.1 110804355 4210207 complement(311400..311852) 1 NC_008258.1 Code: KR; COG: COG0454; hypothetical protein 311852 yafP 4210207 yafP Shigella flexneri 5 str. 8401 hypothetical protein YP_687875.1 311400 R 373384 CDS YP_687876.1 110804356 4210208 complement(311862..312260) 1 NC_008258.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function; toxin YafO 312260 yafO 4210208 yafO Shigella flexneri 5 str. 8401 toxin YafO YP_687876.1 311862 R 373384 CDS YP_687877.1 110804357 4210209 complement(312263..312556) 1 NC_008258.1 Code: D; COG: COG2161; antitoxin of the YafO-YafN toxin-antitoxin system 312556 yafN 4210209 yafN Shigella flexneri 5 str. 8401 antitoxin of the YafO-YafN toxin-antitoxin system YP_687877.1 312263 R 373384 CDS YP_687878.1 110804358 4210210 complement(312608..313612) 1 NC_008258.1 tRNA synthetase; involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 313612 dinP 4210210 dinP Shigella flexneri 5 str. 8401 DNA polymerase IV YP_687878.1 312608 R 373384 CDS YP_687879.1 110804360 4210212 complement(313734..314519) 1 NC_008258.1 Code: N; COG: COG1360; hypothetical protein 314519 mbhA 4210212 mbhA Shigella flexneri 5 str. 8401 hypothetical protein YP_687879.1 313734 R 373384 CDS YP_687880.1 110804359 4210211 314464..316203 1 NC_008258.1 Code: NU; COG: COG1298; flagellar biosynthetic protein FlhA 316203 fhiA 4210211 fhiA Shigella flexneri 5 str. 8401 flagellar biosynthetic protein FlhA YP_687880.1 314464 D 373384 CDS YP_687881.1 110804361 4210213 complement(316420..316917) 1 NC_008258.1 Code: L; COG: COG1943; hypothetical protein 316917 yafM 4210213 yafM Shigella flexneri 5 str. 8401 hypothetical protein YP_687881.1 316420 R 373384 CDS YP_687882.1 110804362 4210214 complement(317093..317647) 1 NC_008258.1 Code: M; COG: COG0791; lipoprotein 317647 yafL 4210214 yafL Shigella flexneri 5 str. 8401 lipoprotein YP_687882.1 317093 R 373384 CDS YP_687883.1 110804363 4210215 317998..318738 1 NC_008258.1 Code: S; COG: COG3034; hypothetical protein 318738 yafK 4210215 yafK Shigella flexneri 5 str. 8401 hypothetical protein YP_687883.1 317998 D 373384 CDS YP_687884.1 110804364 4210216 complement(318709..319476) 1 NC_008258.1 Code: R; COG: COG0121; amidotransferase 319476 yafJ 4210216 yafJ Shigella flexneri 5 str. 8401 amidotransferase YP_687884.1 318709 R 373384 CDS YP_687885.1 110804365 4210217 complement(319682..320422) 1 NC_008258.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 320422 gmhA 4210217 gmhA Shigella flexneri 5 str. 8401 phosphoheptose isomerase YP_687885.1 319682 R 373384 CDS YP_687886.1 110804366 4210218 320500..322944 1 NC_008258.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 322944 fadE 4210218 fadE Shigella flexneri 5 str. 8401 acyl-CoA dehydrogenase YP_687886.1 320500 D 373384 CDS YP_687887.1 110804367 4210219 complement(322987..323460) 1 NC_008258.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 323460 ykfE 4210219 ykfE Shigella flexneri 5 str. 8401 C-lysozyme inhibitor YP_687887.1 322987 R 373384 CDS YP_687888.1 110804368 4210220 323617..324387 1 NC_008258.1 Code: R; COG: COG0388; hypothetical protein 324387 yafV 4210220 yafV Shigella flexneri 5 str. 8401 hypothetical protein YP_687888.1 323617 D 373384 CDS YP_687889.1 110804369 4210221 complement(325436..326230) 1 NC_008258.1 Rhs family protein 326230 4210221 SFV_0310 Shigella flexneri 5 str. 8401 Rhs family protein YP_687889.1 325436 R 373384 CDS YP_687890.1 110804370 4210222 complement(326422..328734) 1 NC_008258.1 Rhs family protein 328734 4210222 SFV_0311 Shigella flexneri 5 str. 8401 Rhs family protein YP_687890.1 326422 R 373384 CDS YP_687891.1 110804371 4210223 complement(328896..329303) 1 NC_008258.1 Rhs family protein 329303 4210223 SFV_0312 Shigella flexneri 5 str. 8401 Rhs family protein YP_687891.1 328896 R 373384 CDS YP_687892.1 110804372 4210224 complement(329325..329771) 1 NC_008258.1 Code: S; COG: COG5435; cytoplasmic protein 329771 4210224 SFV_0313 Shigella flexneri 5 str. 8401 cytoplasmic protein YP_687892.1 329325 R 373384 CDS YP_687893.1 110804373 4210225 complement(329794..332007) 1 NC_008258.1 Code: S; COG: COG3501; Rhs family protein 332007 4210225 SFV_0314 Shigella flexneri 5 str. 8401 Rhs family protein YP_687893.1 329794 R 373384 CDS YP_687894.1 110804374 4210226 complement(333085..333588) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 333588 insB 4210226 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_687894.1 333085 R 373384 CDS YP_687895.1 110804375 4210227 333663..333878 1 NC_008258.1 IS1 encoded protein 333878 4210227 SFV_0316 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_687895.1 333663 D 373384 CDS YP_687896.1 110804376 4210228 334201..334920 1 NC_008258.1 Code: C; COG: COG0247; dehydrogenase subunit 334920 ykgE 4210228 ykgE Shigella flexneri 5 str. 8401 dehydrogenase subunit YP_687896.1 334201 D 373384 CDS YP_687897.1 110804377 4210229 334931..336358 1 NC_008258.1 Code: C; COG: COG1139; hypothetical protein 336358 ykgF 4210229 ykgF Shigella flexneri 5 str. 8401 hypothetical protein YP_687897.1 334931 D 373384 CDS YP_687898.1 110804378 4206840 336351..337046 1 NC_008258.1 Code: S; COG: COG1556; transporter 337046 ykgG 4206840 ykgG Shigella flexneri 5 str. 8401 transporter YP_687898.1 336351 D 373384 CDS YP_687899.1 110804379 4206841 complement(337001..337213) 1 NC_008258.1 hypothetical protein 337213 4206841 SFV_0320 Shigella flexneri 5 str. 8401 hypothetical protein YP_687899.1 337001 R 373384 CDS YP_687900.1 110804380 4206842 complement(337289..337957) 1 NC_008258.1 hypothetical protein 337957 ykgH 4206842 ykgH Shigella flexneri 5 str. 8401 hypothetical protein YP_687900.1 337289 R 373384 CDS YP_687901.1 110804381 4206843 complement(338171..339841) 1 NC_008258.1 a flavoprotein; catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 339841 betA 4206843 betA Shigella flexneri 5 str. 8401 choline dehydrogenase YP_687901.1 338171 R 373384 CDS YP_687902.1 110804382 4206844 complement(339855..341327) 1 NC_008258.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 341327 betB 4206844 betB Shigella flexneri 5 str. 8401 betaine aldehyde dehydrogenase YP_687902.1 339855 R 373384 CDS YP_687903.1 110804383 4206845 complement(341341..341928) 1 NC_008258.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 341928 betI 4206845 betI Shigella flexneri 5 str. 8401 transcriptional regulator BetI YP_687903.1 341341 R 373384 CDS YP_687904.1 110804384 4206846 342056..344089 1 NC_008258.1 proton-motive-force-driven choline transporter; choline transport protein BetT 344089 betT 4206846 betT Shigella flexneri 5 str. 8401 choline transport protein BetT YP_687904.1 342056 D 373384 CDS YP_687905.1 110804385 4206847 complement(344232..344423) 1 NC_008258.1 IS1 encoded protein 344423 4206847 SFV_0326 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_687905.1 344232 R 373384 CDS YP_687906.1 110804386 4206848 344498..345001 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 345001 insB 4206848 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_687906.1 344498 D 373384 CDS YP_687907.1 110804387 4206849 complement(345115..347208) 1 NC_008258.1 Code: L; COG: COG2801; phage transposase 347208 4206849 SFV_0328 Shigella flexneri 5 str. 8401 phage transposase YP_687907.1 345115 R 373384 CDS YP_687908.1 110804388 4206850 348610..349380 1 NC_008258.1 Code: P; COG: COG4521; taurine ABC transporter substrate-binding protein 349380 tauA 4206850 tauA Shigella flexneri 5 str. 8401 taurine ABC transporter substrate-binding protein YP_687908.1 348610 D 373384 CDS YP_687909.1 110804389 4206851 349393..350160 1 NC_008258.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine ABC transporter ATP-binding protein 350160 tauB 4206851 tauB Shigella flexneri 5 str. 8401 taurine ABC transporter ATP-binding protein YP_687909.1 349393 D 373384 CDS YP_687910.1 110804390 4206852 350157..350984 1 NC_008258.1 Code: P; COG: COG0600; taurine transporter subunit 350984 tauC 4206852 tauC Shigella flexneri 5 str. 8401 taurine transporter subunit YP_687910.1 350157 D 373384 CDS YP_687911.1 110804391 4206853 350981..351832 1 NC_008258.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 351832 tauD 4206853 tauD Shigella flexneri 5 str. 8401 taurine dioxygenase YP_687911.1 350981 D 373384 CDS YP_687912.1 110804392 4206854 complement(351938..352945) 1 NC_008258.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 352945 hemB 4206854 hemB Shigella flexneri 5 str. 8401 delta-aminolevulinic acid dehydratase YP_687912.1 351938 R 373384 CDS YP_687913.1 110804393 4206856 353899..354264 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 354264 4206856 SFV_0335 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_687913.1 353899 D 373384 CDS YP_687914.1 110804394 4206857 354288..355001 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 355001 4206857 SFV_0336 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_687914.1 354288 D 373384 CDS YP_687915.1 110804395 4206858 355207..356019 1 NC_008258.1 Code: L; COG: COG2801; ISEhe3 orfB 356019 4206858 SFV_0337 Shigella flexneri 5 str. 8401 ISEhe3 orfB YP_687915.1 355207 D 373384 CDS YP_687916.1 110804396 4209173 356609..357157 1 NC_008258.1 hypothetical protein 357157 yaiV 4209173 yaiV Shigella flexneri 5 str. 8401 hypothetical protein YP_687916.1 356609 D 373384 CDS YP_687917.1 110804397 4209174 complement(357158..358315) 1 NC_008258.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 358315 yaiH 4209174 yaiH Shigella flexneri 5 str. 8401 beta-lactam binding protein AmpH YP_687917.1 357158 R 373384 CDS YP_687918.1 110804398 4209175 358667..359887 1 NC_008258.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transport protein 359887 sbmA 4209175 sbmA Shigella flexneri 5 str. 8401 transport protein YP_687918.1 358667 D 373384 CDS YP_687919.1 110804399 4209176 359900..360994 1 NC_008258.1 hypothetical protein 360994 yaiW 4209176 yaiW Shigella flexneri 5 str. 8401 hypothetical protein YP_687919.1 359900 D 373384 CDS YP_687920.1 110804400 4209177 complement(361053..361361) 1 NC_008258.1 hypothetical protein 361361 4209177 SFV_0342 Shigella flexneri 5 str. 8401 hypothetical protein YP_687920.1 361053 R 373384 CDS YP_687921.1 110804401 4209178 361489..361833 1 NC_008258.1 hypothetical protein 361833 4209178 SFV_0343 Shigella flexneri 5 str. 8401 hypothetical protein YP_687921.1 361489 D 373384 CDS YP_687922.1 110804402 4209179 complement(361857..362897) 1 NC_008258.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 362897 ddl 4209179 ddl Shigella flexneri 5 str. 8401 D-alanyl-alanine synthetase A YP_687922.1 361857 R 373384 CDS YP_687923.1 110804403 4209180 363414..363674 1 NC_008258.1 hypothetical protein 363674 yaiB 4209180 yaiB Shigella flexneri 5 str. 8401 hypothetical protein YP_687923.1 363414 D 373384 CDS YP_687924.1 110804404 4209181 363775..365190 1 NC_008258.1 Code: P; COG: COG1785; alkaline phosphatase 365190 phoA 4209181 phoA Shigella flexneri 5 str. 8401 alkaline phosphatase YP_687924.1 363775 D 373384 CDS YP_687925.1 110804405 4209182 365291..365629 1 NC_008258.1 hypothetical protein 365629 psiF 4209182 psiF Shigella flexneri 5 str. 8401 hypothetical protein YP_687925.1 365291 D 373384 CDS YP_687926.1 110804406 4209183 complement(365680..366567) 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 366567 4209183 SFV_0348 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_687926.1 365680 R 373384 CDS YP_687927.1 110804407 4209184 complement(366567..366893) 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 366893 4209184 SFV_0349 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_687927.1 366567 R 373384 CDS YP_687928.1 110804408 4209185 367044..368159 1 NC_008258.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 368159 adrA 4209185 adrA Shigella flexneri 5 str. 8401 diguanylate cyclase AdrA YP_687928.1 367044 D 373384 CDS YP_687929.1 110804409 4209186 complement(368176..368985) 1 NC_008258.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 368985 proC 4209186 proC Shigella flexneri 5 str. 8401 pyrroline-5-carboxylate reductase YP_687929.1 368176 R 373384 CDS YP_687930.1 110804410 4209187 368985..369563 1 NC_008258.1 Code: S; COG: COG1671; hypothetical protein 369563 yaiI 4209187 yaiI Shigella flexneri 5 str. 8401 hypothetical protein YP_687930.1 368985 D 373384 CDS YP_687931.1 110804411 4209188 369746..370270 1 NC_008258.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase II 370270 aroL 4209188 aroL Shigella flexneri 5 str. 8401 shikimate kinase II YP_687931.1 369746 D 373384 CDS YP_687932.1 110804412 4209189 370320..370511 1 NC_008258.1 hypothetical protein 370511 yaiA 4209189 yaiA Shigella flexneri 5 str. 8401 hypothetical protein YP_687932.1 370320 D 373384 CDS YP_687933.1 110804413 4209190 370769..371446 1 NC_008258.1 hypothetical protein 371446 aroM 4209190 aroM Shigella flexneri 5 str. 8401 hypothetical protein YP_687933.1 370769 D 373384 CDS YP_687934.1 110804414 4209191 371518..371802 1 NC_008258.1 Code: S; COG: COG3123; hypothetical protein 371802 yaiE 4209191 yaiE Shigella flexneri 5 str. 8401 hypothetical protein YP_687934.1 371518 D 373384 CDS YP_687935.1 110804415 4209192 372011..372292 1 NC_008258.1 hypothetical protein 372292 4209192 SFV_0357 Shigella flexneri 5 str. 8401 hypothetical protein YP_687935.1 372011 D 373384 CDS YP_687936.1 110804416 4209806 372289..372744 1 NC_008258.1 hypothetical protein 372744 4209806 SFV_0358 Shigella flexneri 5 str. 8401 hypothetical protein YP_687936.1 372289 D 373384 CDS YP_687937.2 162139360 4209808 complement(372822..373733) 1 NC_008258.1 Required for efficient pilin antigenic variation; recombination associated protein 373733 rdgC 4209808 rdgC Shigella flexneri 5 str. 8401 recombination associated protein YP_687937.2 372822 R 373384 CDS YP_687938.1 110804417 4209807 373720..374766 1 NC_008258.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 374766 yajF 4209807 yajF Shigella flexneri 5 str. 8401 fructokinase YP_687938.1 373720 D 373384 CDS YP_687939.1 110804419 4209809 complement(374909..376186) 1 NC_008258.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 376186 araJ 4209809 araJ Shigella flexneri 5 str. 8401 MFS transport protein AraJ YP_687939.1 374909 R 373384 CDS YP_687940.1 110804420 4209810 complement(376216..379359) 1 NC_008258.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 379359 sbcC 4209810 sbcC Shigella flexneri 5 str. 8401 exonuclease SbcC YP_687940.1 376216 R 373384 CDS YP_687941.1 110804421 4209811 complement(379356..380558) 1 NC_008258.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD 380558 sbcD 4209811 sbcD Shigella flexneri 5 str. 8401 exonuclease SbcD YP_687941.1 379356 R 373384 CDS YP_687942.1 110804422 4209812 380748..381437 1 NC_008258.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 381437 phoB 4209812 phoB Shigella flexneri 5 str. 8401 transcriptional regulator PhoB YP_687942.1 380748 D 373384 CDS YP_687943.1 110804423 4209813 381495..382790 1 NC_008258.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 382790 phoR 4209813 phoR Shigella flexneri 5 str. 8401 phosphate regulon sensor protein YP_687943.1 381495 D 373384 CDS YP_687944.1 110804424 4209814 383197..384516 1 NC_008258.1 Code: E; COG: COG1114; branched chain amino acid ABC transporter carrier protein 384516 brnQ 4209814 brnQ Shigella flexneri 5 str. 8401 branched chain amino acid ABC transporter carrier protein YP_687944.1 383197 D 373384 CDS YP_687945.1 110804425 4209815 384592..385965 1 NC_008258.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; proline-specific permease 385965 proY 4209815 proY Shigella flexneri 5 str. 8401 proline-specific permease YP_687945.1 384592 D 373384 CDS YP_687946.1 110804426 4209816 386124..387938 1 NC_008258.1 Code: G; COG: COG0366; maltodextrin glucosidase 387938 malZ 4209816 malZ Shigella flexneri 5 str. 8401 maltodextrin glucosidase YP_687946.1 386124 D 373384 CDS YP_687947.1 110804427 4209818 388609..389679 1 NC_008258.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 389679 queA 4209818 queA Shigella flexneri 5 str. 8401 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_687947.1 388609 D 373384 CDS YP_687948.1 110804428 4209819 389734..390861 1 NC_008258.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 390861 tgt 4209819 tgt Shigella flexneri 5 str. 8401 queuine tRNA-ribosyltransferase YP_687948.1 389734 D 373384 CDS YP_687949.1 110804429 4209820 390884..391216 1 NC_008258.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 391216 yajC 4209820 yajC Shigella flexneri 5 str. 8401 preprotein translocase subunit YajC YP_687949.1 390884 D 373384 CDS YP_687950.2 162139359 4209821 391244..393091 1 NC_008258.1 protein secretion; membrane protein, part of the channel; part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 393091 secD 4209821 secD Shigella flexneri 5 str. 8401 preprotein translocase subunit SecD YP_687950.2 391244 D 373384 CDS YP_687951.1 110804431 4209822 393102..394073 1 NC_008258.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 394073 secF 4209822 secF Shigella flexneri 5 str. 8401 preprotein translocase subunit SecF YP_687951.1 393102 D 373384 CDS YP_687952.1 110804432 4209823 394202..394549 1 NC_008258.1 hypothetical protein 394549 yajD 4209823 yajD Shigella flexneri 5 str. 8401 hypothetical protein YP_687952.1 394202 D 373384 CDS YP_687953.1 110804433 4209824 complement(394726..395610) 1 NC_008258.1 nucleoside channel; receptor of phage T6 and colicin K; Code: M; COG: COG3248; outer membrane protein Tsx 395610 tsx 4209824 tsx Shigella flexneri 5 str. 8401 outer membrane protein Tsx YP_687953.1 394726 R 373384 CDS YP_687954.1 110804434 4209786 complement(395908..396507) 1 NC_008258.1 hypothetical protein 396507 yajI 4209786 yajI Shigella flexneri 5 str. 8401 hypothetical protein YP_687954.1 395908 R 373384 CDS YP_687955.1 110804435 4209787 396598..397047 1 NC_008258.1 Code: K; COG: COG1327; transcriptional regulator NrdR 397047 nrdR 4209787 nrdR Shigella flexneri 5 str. 8401 transcriptional regulator NrdR YP_687955.1 396598 D 373384 CDS YP_687956.1 110804436 4209788 397069..398154 1 NC_008258.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 398154 ribD 4209788 ribD Shigella flexneri 5 str. 8401 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_687956.1 397069 D 373384 CDS YP_687957.1 110804437 4209789 398189..398713 1 NC_008258.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 398713 ribH 4209789 ribH Shigella flexneri 5 str. 8401 6,7-dimethyl-8-ribityllumazine synthase YP_687957.1 398189 D 373384 CDS YP_687958.1 110804438 4209790 398733..399152 1 NC_008258.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 399152 nusB 4209790 nusB Shigella flexneri 5 str. 8401 transcription antitermination protein NusB YP_687958.1 398733 D 373384 CDS YP_687959.1 110804439 4209791 399230..400207 1 NC_008258.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 400207 thiL 4209791 thiL Shigella flexneri 5 str. 8401 thiamine monophosphate kinase YP_687959.1 399230 D 373384 CDS YP_687960.1 110804440 4209792 400194..400703 1 NC_008258.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 400703 pgpA 4209792 pgpA Shigella flexneri 5 str. 8401 phosphatidylglycerophosphatase A YP_687960.1 400194 D 373384 CDS YP_687961.1 110804441 4209793 complement(400757..401731) 1 NC_008258.1 Code: C; COG: COG0667; NAD(P)H-dependent xylose reductase 401731 yajO 4209793 yajO Shigella flexneri 5 str. 8401 NAD(P)H-dependent xylose reductase YP_687961.1 400757 R 373384 CDS YP_687962.2 162139358 4209794 complement(401786..403648) 1 NC_008258.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 403648 dxs 4209794 dxs Shigella flexneri 5 str. 8401 1-deoxy-D-xylulose-5-phosphate synthase YP_687962.2 401786 R 373384 CDS YP_687963.1 110804443 4209795 complement(403673..404572) 1 NC_008258.1 Code: H; COG: COG0142; geranyltranstransferase 404572 ispA 4209795 ispA Shigella flexneri 5 str. 8401 geranyltranstransferase YP_687963.1 403673 R 373384 CDS YP_687964.1 110804444 4209796 complement(404572..404814) 1 NC_008258.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 404814 xseB 4209796 xseB Shigella flexneri 5 str. 8401 exodeoxyribonuclease VII small subunit YP_687964.1 404572 R 373384 CDS YP_687965.1 110804445 4209797 405020..406468 1 NC_008258.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 406468 yajK 4209797 yajK Shigella flexneri 5 str. 8401 thiamine biosynthesis protein ThiI YP_687965.1 405020 D 373384 CDS YP_687966.1 110804446 4209798 complement(406522..407112) 1 NC_008258.1 Code: R; COG: COG0693; DJ-1 family protein 407112 thiJ 4209798 thiJ Shigella flexneri 5 str. 8401 DJ-1 family protein YP_687966.1 406522 R 373384 CDS YP_687967.1 110804447 4209799 complement(407075..407986) 1 NC_008258.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 407986 apbA 4209799 apbA Shigella flexneri 5 str. 8401 2-dehydropantoate 2-reductase YP_687967.1 407075 R 373384 CDS YP_687968.1 110804448 4209800 408154..408645 1 NC_008258.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 408645 yajQ 4209800 yajQ Shigella flexneri 5 str. 8401 nucleotide-binding protein YP_687968.1 408154 D 373384 CDS YP_687969.1 110804449 4209801 complement(408705..410435) 1 NC_008258.1 hypothetical protein 410435 4209801 SFV_0392 Shigella flexneri 5 str. 8401 hypothetical protein YP_687969.1 408705 R 373384 CDS YP_687970.1 110804450 4209802 complement(410488..412641) 1 NC_008258.1 Code: S; COG: COG2849; hypothetical protein 412641 4209802 SFV_0393 Shigella flexneri 5 str. 8401 hypothetical protein YP_687970.1 410488 R 373384 CDS YP_687971.1 110804451 4209803 complement(412823..414193) 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 414193 yajR 4209803 yajR Shigella flexneri 5 str. 8401 transport protein YP_687971.1 412823 R 373384 CDS YP_687972.1 110804452 4209804 414587..415861 1 NC_008258.1 Code: R; COG: COG0790; hypothetical protein 415861 4209804 SFV_0395 Shigella flexneri 5 str. 8401 hypothetical protein YP_687972.1 414587 D 373384 CDS YP_687973.1 110804453 4209805 416098..417033 1 NC_008258.1 hypothetical protein 417033 4209805 SFV_0396 Shigella flexneri 5 str. 8401 hypothetical protein YP_687973.1 416098 D 373384 CDS YP_687974.1 110804454 4209825 complement(417089..417487) 1 NC_008258.1 Code: KR; COG: COG0454; hypothetical protein 417487 4209825 SFV_0397 Shigella flexneri 5 str. 8401 hypothetical protein YP_687974.1 417089 R 373384 CDS YP_687975.1 110804455 4209826 complement(417622..417981) 1 NC_008258.1 Code: S; COG: COG4453; hypothetical protein 417981 4209826 SFV_0398 Shigella flexneri 5 str. 8401 hypothetical protein YP_687975.1 417622 R 373384 CDS YP_687976.1 110804456 4209828 complement(419020..419349) 1 NC_008258.1 Code: C; COG: COG3125; cytochrome o ubiquinol oxidase subunit IV 419349 cyoD 4209828 cyoD Shigella flexneri 5 str. 8401 cytochrome o ubiquinol oxidase subunit IV YP_687976.1 419020 R 373384 CDS YP_687977.1 110804457 4209829 complement(419349..419963) 1 NC_008258.1 Code: C; COG: COG1845; cytochrome o ubiquinol oxidase subunit III 419963 cyoC 4209829 cyoC Shigella flexneri 5 str. 8401 cytochrome o ubiquinol oxidase subunit III YP_687977.1 419349 R 373384 CDS YP_687978.1 110804458 4209832 complement(422496..423302) 1 NC_008258.1 ISSfl4 ORF3 423302 4209832 SFV_0404 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_687978.1 422496 R 373384 CDS YP_687979.1 110804459 4209833 complement(423278..423412) 1 NC_008258.1 ISSfl4 ORF3 423412 4209833 SFV_0405 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_687979.1 423278 R 373384 CDS YP_687980.1 110804460 4209834 complement(423432..423779) 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 423779 4209834 SFV_0406 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_687980.1 423432 R 373384 CDS YP_687981.1 110804461 4209835 complement(423776..424450) 1 NC_008258.1 ISSfl4 ORF1 424450 4209835 SFV_0407 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_687981.1 423776 R 373384 CDS YP_687982.1 110804462 4209836 complement(424820..426295) 1 NC_008258.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 426295 ampG 4209836 ampG Shigella flexneri 5 str. 8401 muropeptide transporter YP_687982.1 424820 R 373384 CDS YP_687983.1 110804463 4209837 complement(426339..427019) 1 NC_008258.1 Code: M; COG: COG3056; hypothetical protein 427019 yajG 4209837 yajG Shigella flexneri 5 str. 8401 hypothetical protein YP_687983.1 426339 R 373384 CDS YP_687984.1 110804464 4209838 427883..429181 1 NC_008258.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 429181 tig 4209838 tig Shigella flexneri 5 str. 8401 trigger factor YP_687984.1 427883 D 373384 CDS YP_687985.1 110804465 4209839 429428..430051 1 NC_008258.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 430051 clpP 4209839 clpP Shigella flexneri 5 str. 8401 ATP-dependent Clp protease proteolytic subunit YP_687985.1 429428 D 373384 CDS YP_687986.1 110804466 4209840 430177..431451 1 NC_008258.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 431451 clpX 4209840 clpX Shigella flexneri 5 str. 8401 ATP-dependent protease ATP-binding subunit ClpX YP_687986.1 430177 D 373384 CDS YP_687987.1 110804467 4209841 431639..433993 1 NC_008258.1 heat shock K-protein; Code: O; COG: COG0466; DNA-binding ATP-dependent protease La 433993 lon 4209841 lon Shigella flexneri 5 str. 8401 DNA-binding ATP-dependent protease La YP_687987.1 431639 D 373384 CDS YP_687988.1 110804468 4209842 434202..434474 1 NC_008258.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 434474 hupB 4209842 hupB Shigella flexneri 5 str. 8401 transcriptional regulator HU subunit beta YP_687988.1 434202 D 373384 CDS YP_687989.1 110804469 4209843 434666..436537 1 NC_008258.1 Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase 436537 ybaU 4209843 ybaU Shigella flexneri 5 str. 8401 peptidyl-prolyl cis-trans isomerase YP_687989.1 434666 D 373384 CDS YP_687990.1 110804470 4209844 436688..437059 1 NC_008258.1 Code: L; COG: COG1555; hypothetical protein 437059 ybaV 4209844 ybaV Shigella flexneri 5 str. 8401 hypothetical protein YP_687990.1 436688 D 373384 CDS YP_687991.1 110804471 4209845 437153..437551 1 NC_008258.1 Code: R; COG: COG0824; hypothetical protein 437551 ybaW 4209845 ybaW Shigella flexneri 5 str. 8401 hypothetical protein YP_687991.1 437153 D 373384 CDS YP_687992.1 110804472 4209846 complement(437603..438298) 1 NC_008258.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 438298 ybaX 4209846 ybaX Shigella flexneri 5 str. 8401 queuosine biosynthesis protein QueC YP_687992.1 437603 R 373384 CDS YP_687993.1 110804473 4209847 complement(438363..439787) 1 NC_008258.1 Code: R; COG: COG4533; hypothetical protein 439787 ybaE 4209847 ybaE Shigella flexneri 5 str. 8401 hypothetical protein YP_687993.1 438363 R 373384 CDS YP_687994.1 110804474 4209848 440155..440973 1 NC_008258.1 Code: R; COG: COG0561; hypothetical protein 440973 cof 4209848 cof Shigella flexneri 5 str. 8401 hypothetical protein YP_687994.1 440155 D 373384 CDS YP_687995.1 110804475 4209849 441019..441585 1 NC_008258.1 Code: K; COG: COG1522; LRP-like transcriptional regulator 441585 ybaO 4209849 ybaO Shigella flexneri 5 str. 8401 LRP-like transcriptional regulator YP_687995.1 441019 D 373384 CDS YP_687996.1 110804476 4209850 441615..443387 1 NC_008258.1 Code: V; COG: COG1132; multidrug transporter membrane\ATP-binding proteins 443387 mdlA 4209850 mdlA Shigella flexneri 5 str. 8401 multidrug transporter membrane\ATP-binding proteins YP_687996.1 441615 D 373384 CDS YP_687997.1 110804477 4209851 443380..445161 1 NC_008258.1 Code: V; COG: COG1132; multidrug transporter membrane\ATP-binding proteins 445161 mdlB 4209851 mdlB Shigella flexneri 5 str. 8401 multidrug transporter membrane\ATP-binding proteins YP_687997.1 443380 D 373384 CDS YP_687998.1 110804478 4209852 445204..445680 1 NC_008258.1 Code: E; COG: COG0347; nitrogen regulatory protein P-II 2 445680 glnK 4209852 glnK Shigella flexneri 5 str. 8401 nitrogen regulatory protein P-II 2 YP_687998.1 445204 D 373384 CDS YP_687999.1 110804479 4209853 445710..446996 1 NC_008258.1 Code: P; COG: COG0004; ammonium transporter 446996 amtB 4209853 amtB Shigella flexneri 5 str. 8401 ammonium transporter YP_687999.1 445710 D 373384 CDS YP_688000.1 110804480 4209854 complement(447045..447905) 1 NC_008258.1 Code: I; COG: COG1946; acyl-CoA thioesterase 447905 tesB 4209854 tesB Shigella flexneri 5 str. 8401 acyl-CoA thioesterase YP_688000.1 447045 R 373384 CDS YP_688001.1 110804481 4209855 448123..448695 1 NC_008258.1 Code: S; COG: COG3126; hypothetical protein 448695 ybaY 4209855 ybaY Shigella flexneri 5 str. 8401 hypothetical protein YP_688001.1 448123 D 373384 CDS YP_688002.1 110804482 4209856 448788..450134 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 450134 4209856 SFV_0428 Shigella flexneri 5 str. 8401 IS4 orf YP_688002.1 448788 D 373384 CDS YP_688003.1 110804483 4209857 complement(450164..450553) 1 NC_008258.1 Code: L; COG: COG3695; hypothetical protein 450553 ybaZ 4209857 ybaZ Shigella flexneri 5 str. 8401 hypothetical protein YP_688003.1 450164 R 373384 CDS YP_688004.1 110804484 4209858 450854..451207 1 NC_008258.1 Code: S; COG: COG5507; hypothetical protein 451207 ybaA 4209858 ybaA Shigella flexneri 5 str. 8401 hypothetical protein YP_688004.1 450854 D 373384 CDS YP_688005.1 110804485 4209859 complement(451249..452805) 1 NC_008258.1 Code: T; COG: COG4943; hypothetical protein 452805 ylaB 4209859 ylaB Shigella flexneri 5 str. 8401 hypothetical protein YP_688005.1 451249 R 373384 CDS YP_688006.1 110804486 4209860 complement(452963..453472) 1 NC_008258.1 hypothetical protein 453472 ylaC 4209860 ylaC Shigella flexneri 5 str. 8401 hypothetical protein YP_688006.1 452963 R 373384 CDS YP_688007.1 110804487 4209861 complement(453549..454100) 1 NC_008258.1 Code: R; COG: COG0110; maltose O-acetyltransferase 454100 ylaD 4209861 ylaD Shigella flexneri 5 str. 8401 maltose O-acetyltransferase YP_688007.1 453549 R 373384 CDS YP_688008.1 110804488 4209862 complement(454516..454890) 1 NC_008258.1 hypothetical protein 454890 ybaJ 4209862 ybaJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688008.1 454516 R 373384 CDS YP_688009.1 110804489 4209863 complement(455436..458585) 1 NC_008258.1 Code: V; COG: COG0841; acriflavin resistance protein 458585 acrB 4209863 acrB Shigella flexneri 5 str. 8401 acriflavin resistance protein YP_688009.1 455436 R 373384 CDS YP_688010.1 110804490 4209997 complement(458608..459837) 1 NC_008258.1 Code: M; COG: COG0845; acriflavin resistance protein A 459837 acrA 4209997 acrA Shigella flexneri 5 str. 8401 acriflavin resistance protein A YP_688010.1 458608 R 373384 CDS YP_688011.1 110804491 4209998 459943..460590 1 NC_008258.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 460590 acrR 4209998 acrR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor AcrR YP_688011.1 459943 D 373384 CDS YP_688012.1 110804492 4209999 460718..464080 1 NC_008258.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 464080 aefA 4209999 aefA Shigella flexneri 5 str. 8401 potassium efflux protein KefA YP_688012.1 460718 D 373384 CDS YP_688013.1 110804493 4210000 complement(464292..464453) 1 NC_008258.1 hypothetical protein 464453 ybaM 4210000 ybaM Shigella flexneri 5 str. 8401 hypothetical protein YP_688013.1 464292 R 373384 CDS YP_688014.1 110804494 4210001 complement(464467..464994) 1 NC_008258.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 464994 priC 4210001 priC Shigella flexneri 5 str. 8401 primosomal replication protein N'' YP_688014.1 464467 R 373384 CDS YP_688015.1 110804495 4210002 465064..465441 1 NC_008258.1 Code: S; COG: COG2832; hypothetical protein 465441 ybaN 4210002 ybaN Shigella flexneri 5 str. 8401 hypothetical protein YP_688015.1 465064 D 373384 CDS YP_688016.1 110804496 4210003 465594..466145 1 NC_008258.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 466145 apt 4210003 apt Shigella flexneri 5 str. 8401 adenine phosphoribosyltransferase YP_688016.1 465594 D 373384 CDS YP_688017.1 110804497 4210004 466274..468199 1 NC_008258.1 DNA elongation factor III; catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 468199 dnaX 4210004 dnaX Shigella flexneri 5 str. 8401 DNA polymerase III subunits gamma and tau YP_688017.1 466274 D 373384 CDS YP_688018.1 110804498 4210005 468252..468581 1 NC_008258.1 Code: S; COG: COG0718; hypothetical protein 468581 ybaB 4210005 ybaB Shigella flexneri 5 str. 8401 hypothetical protein YP_688018.1 468252 D 373384 CDS YP_688019.1 110804499 4210006 468581..469186 1 NC_008258.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 469186 recR 4210006 recR Shigella flexneri 5 str. 8401 recombination protein RecR YP_688019.1 468581 D 373384 CDS YP_688020.1 110804500 4210008 471350..471994 1 NC_008258.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 471994 adk 4210008 adk Shigella flexneri 5 str. 8401 adenylate kinase YP_688020.1 471350 D 373384 CDS YP_688021.1 110804501 4210009 472126..473088 1 NC_008258.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 473088 hemH 4210009 hemH Shigella flexneri 5 str. 8401 ferrochelatase YP_688021.1 472126 D 373384 CDS YP_688022.1 110804502 4210010 complement(473085..474044) 1 NC_008258.1 Code: I; COG: COG0657; acetyl esterase 474044 ybaC 4210010 ybaC Shigella flexneri 5 str. 8401 acetyl esterase YP_688022.1 473085 R 373384 CDS YP_688023.1 110804503 4210011 474196..475500 1 NC_008258.1 inosine-guanosine kinase 475500 gsk 4210011 gsk Shigella flexneri 5 str. 8401 inosine-guanosine kinase YP_688023.1 474196 D 373384 CDS YP_688024.1 110804504 4210012 complement(475633..477309) 1 NC_008258.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 477309 ybaL 4210012 ybaL Shigella flexneri 5 str. 8401 cation:proton antiport protein YP_688024.1 475633 R 373384 CDS YP_688025.1 110804505 4210013 complement(477547..478767) 1 NC_008258.1 Code: GEPR; COG: COG0477; fosmidomycin resistance protein 478767 fsr 4210013 fsr Shigella flexneri 5 str. 8401 fosmidomycin resistance protein YP_688025.1 477547 R 373384 CDS YP_688026.1 110804506 4210015 complement(480673..481152) 1 NC_008258.1 Code: S; COG: COG2606; hypothetical protein 481152 ybaK 4210015 ybaK Shigella flexneri 5 str. 8401 hypothetical protein YP_688026.1 480673 R 373384 CDS YP_688027.1 110804507 4210016 complement(481356..482150) 1 NC_008258.1 Code: S; COG: COG3735; ligase 482150 ybaP 4210016 ybaP Shigella flexneri 5 str. 8401 ligase YP_688027.1 481356 R 373384 CDS YP_688028.1 110804508 4210017 482234..482629 1 NC_008258.1 Code: R; COG: COG3093; hypothetical protein 482629 ybaQ 4210017 ybaQ Shigella flexneri 5 str. 8401 hypothetical protein YP_688028.1 482234 D 373384 CDS YP_688029.1 110804509 4210018 complement(482844..485348) 1 NC_008258.1 Code: P; COG: COG2217; copper exporting ATPase 485348 copA 4210018 copA Shigella flexneri 5 str. 8401 copper exporting ATPase YP_688029.1 482844 R 373384 CDS YP_688030.1 110804510 4210019 485610..486542 1 NC_008258.1 catalyzes the formation of glutamate from glutamine; glutaminase 486542 ybaS 4210019 ybaS Shigella flexneri 5 str. 8401 glutaminase YP_688030.1 485610 D 373384 CDS YP_688031.1 110804511 4210020 486545..487837 1 NC_008258.1 Code: E; COG: COG0531; amino acid/amine transport protein 487837 ybaT 4210020 ybaT Shigella flexneri 5 str. 8401 amino acid/amine transport protein YP_688031.1 486545 D 373384 CDS YP_688032.1 110804512 4210021 487962..488372 1 NC_008258.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 488372 ybbI 4210021 ybbI Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator CueR YP_688032.1 487962 D 373384 CDS YP_688033.1 110804513 4210022 complement(488369..488815) 1 NC_008258.1 Code: OU; COG: COG1585; hypothetical protein 488815 ybbJ 4210022 ybbJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688033.1 488369 R 373384 CDS YP_688034.1 110804514 4210023 complement(488824..489741) 1 NC_008258.1 Code: O; COG: COG0330; protease 489741 ybbK 4210023 ybbK Shigella flexneri 5 str. 8401 protease YP_688034.1 488824 R 373384 CDS YP_688035.1 110804515 4210024 489887..490564 1 NC_008258.1 Code: R; COG: COG4619; ABC transporter ATP-binding protein YbbL 490564 ybbL 4210024 ybbL Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YbbL YP_688035.1 489887 D 373384 CDS YP_688036.1 110804516 4210025 490551..491330 1 NC_008258.1 Code: R; COG: COG0390; metal resistance protein 491330 ybbM 4210025 ybbM Shigella flexneri 5 str. 8401 metal resistance protein YP_688036.1 490551 D 373384 CDS YP_688037.1 110804517 4210026 complement(491393..492283) 1 NC_008258.1 Code: O; COG: COG3118; thioredoxin-like protein 492283 ybbN 4210026 ybbN Shigella flexneri 5 str. 8401 thioredoxin-like protein YP_688037.1 491393 R 373384 CDS YP_688038.1 110804518 4210027 complement(492308..493078) 1 NC_008258.1 Code: IQR; COG: COG1028; short chain dehydrogenase 493078 ybbO 4210027 ybbO Shigella flexneri 5 str. 8401 short chain dehydrogenase YP_688038.1 492308 R 373384 CDS YP_688039.1 110804519 4210028 493700..494302 1 NC_008258.1 Code: Q; COG: COG4181; ABC transporter ATP-binding protein 494302 ybbA 4210028 ybbA Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_688039.1 493700 D 373384 CDS YP_688040.1 110804520 4210030 494299..496713 1 NC_008258.1 Code: Q; COG: COG3127; oxidoreductase 496713 ybbP 4210030 ybbP Shigella flexneri 5 str. 8401 oxidoreductase YP_688040.1 494299 D 373384 CDS YP_688041.1 110804521 4210031 complement(497425..498519) 1 NC_008258.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 498519 ybbB 4210031 ybbB Shigella flexneri 5 str. 8401 tRNA 2-selenouridine synthase YP_688041.1 497425 R 373384 CDS YP_688042.1 110804522 4210032 complement(498588..499514) 1 NC_008258.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 499514 ybbS 4210032 ybbS Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator AllS YP_688042.1 498588 R 373384 CDS YP_688043.1 110804523 4210033 499744..500226 1 NC_008258.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 500226 ybbT 4210033 ybbT Shigella flexneri 5 str. 8401 ureidoglycolate hydrolase YP_688043.1 499744 D 373384 CDS YP_688044.1 110804524 4210034 500304..501119 1 NC_008258.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 501119 ybbU 4210034 ybbU Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor AllR YP_688044.1 500304 D 373384 CDS YP_688045.1 110804525 4210035 501155..502984 1 NC_008258.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 502984 gcl 4210035 gcl Shigella flexneri 5 str. 8401 glyoxylate carboligase YP_688045.1 501155 D 373384 CDS YP_688046.1 110804526 4210056 complement(503289..503792) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 503792 insB 4210056 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688046.1 503289 R 373384 CDS YP_688047.1 110804527 4210057 complement(504015..504686) 1 NC_008258.1 Code: R; COG: COG3257; hypothetical protein 504686 ylbA 4210057 ylbA Shigella flexneri 5 str. 8401 hypothetical protein YP_688047.1 504015 R 373384 CDS YP_688048.1 110804528 4210058 complement(504697..505986) 1 NC_008258.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 505986 ylbB 4210058 ylbB Shigella flexneri 5 str. 8401 allantoate amidohydrolase YP_688048.1 504697 R 373384 CDS YP_688049.1 110804529 4210059 505992..506579 1 NC_008258.1 carboxylase 506579 ylbF 4210059 ylbF Shigella flexneri 5 str. 8401 carboxylase YP_688049.1 505992 D 373384 CDS YP_688050.1 110804530 4210060 506576..507469 1 NC_008258.1 Code: E; COG: COG0549; carbamate kinase 507469 arcC 4210060 arcC Shigella flexneri 5 str. 8401 carbamate kinase YP_688050.1 506576 D 373384 CDS YP_688051.1 110804531 4210061 complement(507606..508673) 1 NC_008258.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 508673 purK 4210061 purK Shigella flexneri 5 str. 8401 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_688051.1 507606 R 373384 CDS YP_688052.1 110804532 4210062 complement(508670..509179) 1 NC_008258.1 Code: F; COG: COG0041; phosphoribosylaminoimidazole carboxylase catalytic subunit 509179 purE 4210062 purE Shigella flexneri 5 str. 8401 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_688052.1 508670 R 373384 CDS YP_688053.1 110804533 4210063 complement(509297..510019) 1 NC_008258.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 510019 ybbF 4210063 ybbF Shigella flexneri 5 str. 8401 UDP-2,3-diacylglucosamine hydrolase YP_688053.1 509297 R 373384 CDS YP_688054.1 110804534 4210064 complement(510022..510516) 1 NC_008258.1 Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase B 510516 ppiB 4210064 ppiB Shigella flexneri 5 str. 8401 peptidyl-prolyl cis-trans isomerase B YP_688054.1 510022 R 373384 CDS YP_688055.2 162139357 4210065 510690..512075 1 NC_008258.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 512075 cysS 4210065 cysS Shigella flexneri 5 str. 8401 cysteinyl-tRNA synthetase YP_688055.2 510690 D 373384 CDS YP_688056.1 110804536 4210066 complement(512111..512620) 1 NC_008258.1 Code: R; COG: COG1988; hypothetical protein 512620 ybcI 4210066 ybcI Shigella flexneri 5 str. 8401 hypothetical protein YP_688056.1 512111 R 373384 CDS YP_688057.1 110804537 4210067 complement(512728..512970) 1 NC_008258.1 Code: S; COG: COG2501; hypothetical protein 512970 ybcJ 4210067 ybcJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688057.1 512728 R 373384 CDS YP_688058.1 110804538 4210068 complement(512942..513766) 1 NC_008258.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 513766 folD 4210068 folD Shigella flexneri 5 str. 8401 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_688058.1 512942 R 373384 CDS YP_688059.1 110804539 4210069 514289..514813 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 514813 sfmA 4210069 sfmA Shigella flexneri 5 str. 8401 fimbrial-like protein YP_688059.1 514289 D 373384 CDS YP_688060.1 110804540 4210072 complement(516186..516689) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 516689 insB 4210072 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688060.1 516186 R 373384 CDS YP_688061.1 110804541 4210073 516764..516973 1 NC_008258.1 IS1 encoded protein 516973 4210073 SFV_0492 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688061.1 516764 D 373384 CDS YP_688062.1 110804542 4210075 519076..519591 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial protein 519591 sfmF 4210075 sfmF Shigella flexneri 5 str. 8401 fimbrial protein YP_688062.1 519076 D 373384 CDS YP_688063.2 162139356 4210076 complement(519641..520546) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 520546 4210076 SFV_0495 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_688063.2 519641 R 373384 CDS YP_688064.1 110804544 4210077 complement(520504..520869) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 520869 4210077 SFV_0496 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688064.1 520504 R 373384 CDS YP_688065.1 110804545 4210078 complement(520945..521625) 1 NC_008258.1 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 521625 fimZ 4210078 fimZ Shigella flexneri 5 str. 8401 transcriptional regulator FimZ YP_688065.1 520945 R 373384 CDS YP_688066.1 110804546 4210080 complement(521927..522688) 1 NC_008258.1 thermoregulation of porin biosynthesis; Code: K; COG: COG2207; envelope protein 522688 envY 4210080 envY Shigella flexneri 5 str. 8401 envelope protein YP_688066.1 521927 R 373384 CDS YP_688067.1 110804547 4210081 complement(522871..523761) 1 NC_008258.1 hypothetical protein 523761 ybcH 4210081 ybcH Shigella flexneri 5 str. 8401 hypothetical protein YP_688067.1 522871 R 373384 CDS YP_688068.1 110804548 4210083 complement(526394..528556) 1 NC_008258.1 bacteriophage N4 adsorption protein B 528556 nfrB 4210083 nfrB Shigella flexneri 5 str. 8401 bacteriophage N4 adsorption protein B YP_688068.1 526394 R 373384 CDS YP_688069.1 110804549 4210084 complement(528781..530223) 1 NC_008258.1 Code: T; COG: COG0642; sensor kinase CusS 530223 ybcZ 4210084 ybcZ Shigella flexneri 5 str. 8401 sensor kinase CusS YP_688069.1 528781 R 373384 CDS YP_688070.1 110804550 4210085 complement(530213..530896) 1 NC_008258.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 530896 ylcA 4210085 ylcA Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator CusR YP_688070.1 530213 R 373384 CDS YP_688071.1 110804551 4210087 532459..532791 1 NC_008258.1 Code: S; COG: COG5569; periplasmic copper-binding protein 532791 ylcC 4210087 ylcC Shigella flexneri 5 str. 8401 periplasmic copper-binding protein YP_688071.1 532459 D 373384 CDS YP_688072.1 110804552 4210089 complement(534095..534742) 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 534742 4210089 SFV_0508 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_688072.1 534095 R 373384 CDS YP_688073.1 110804553 4210090 complement(534978..535304) 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 535304 4210090 SFV_0509 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_688073.1 534978 R 373384 CDS YP_688074.1 110804554 4210091 535381..536601 1 NC_008258.1 bacteriophage protein 536601 4210091 SFV_0510 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688074.1 535381 D 373384 CDS YP_688075.1 110804555 4210092 complement(536642..537355) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 537355 4210092 SFV_0511 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688075.1 536642 R 373384 CDS YP_688076.1 110804556 4210093 complement(537496..537798) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 537798 4210093 SFV_0512 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688076.1 537496 R 373384 CDS YP_688077.2 162139355 4210094 complement(539511..540416) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 540416 4210094 SFV_0513 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_688077.2 539511 R 373384 CDS YP_688078.1 110804558 4210095 complement(540374..540739) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 540739 4210095 SFV_0514 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688078.1 540374 R 373384 CDS YP_688079.1 110804559 4210096 541557..544736 1 NC_008258.1 Code: P; COG: COG3696; inner membrane component for iron transport 544736 ybdE 4210096 ybdE Shigella flexneri 5 str. 8401 inner membrane component for iron transport YP_688079.1 541557 D 373384 CDS YP_688080.1 110804560 4210097 544837..546213 1 NC_008258.1 Code: E; COG: COG1113; phenylalanine transporter 546213 pheP 4210097 pheP Shigella flexneri 5 str. 8401 phenylalanine transporter YP_688080.1 544837 D 373384 CDS YP_688081.1 110804561 4210098 complement(546281..547528) 1 NC_008258.1 Code: M; COG: COG0668; transport protein 547528 ybdG 4210098 ybdG Shigella flexneri 5 str. 8401 transport protein YP_688081.1 546281 R 373384 CDS YP_688082.1 110804562 4210099 complement(547636..548289) 1 NC_008258.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 548289 nfnB 4210099 nfnB Shigella flexneri 5 str. 8401 dihydropteridine reductase YP_688082.1 547636 R 373384 CDS YP_688083.1 110804563 4210100 complement(548383..548751) 1 NC_008258.1 Code: S; COG: COG2315; hypothetical protein 548751 ybdF 4210100 ybdF Shigella flexneri 5 str. 8401 hypothetical protein YP_688083.1 548383 R 373384 CDS YP_688084.1 110804564 4210101 complement(548816..549064) 1 NC_008258.1 hypothetical protein 549064 ybdJ 4210101 ybdJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688084.1 548816 R 373384 CDS YP_688085.1 110804565 4210102 complement(549130..550248) 1 NC_008258.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 550248 ybdK 4210102 ybdK Shigella flexneri 5 str. 8401 carboxylate-amine ligase YP_688085.1 549130 R 373384 CDS YP_688086.1 110804566 4210103 550680..551162 1 NC_008258.1 Code: L; COG: COG2963; IS150 ORF1(ORF A) 551162 4210103 SFV_0522 Shigella flexneri 5 str. 8401 IS150 ORF1(ORF A) YP_688086.1 550680 D 373384 CDS YP_688087.1 110804567 4210104 complement(551159..551872) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 551872 4210104 SFV_0523 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688087.1 551159 R 373384 CDS YP_688088.1 110804568 4210105 complement(552142..552789) 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 552789 4210105 SFV_0524 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_688088.1 552142 R 373384 CDS YP_688089.1 110804569 4210106 complement(553025..553351) 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 553351 4210106 SFV_0525 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_688089.1 553025 R 373384 CDS YP_688090.1 110804570 4210107 complement(553403..553624) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 553624 4210107 SFV_0526 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688090.1 553403 R 373384 CDS YP_688091.1 110804571 4210108 553774..554625 1 NC_008258.1 Code: L; COG: COG2801; IS150 ORF2 554625 4210108 SFV_0527 Shigella flexneri 5 str. 8401 IS150 ORF2 YP_688091.1 553774 D 373384 CDS YP_688092.1 110804572 4210109 complement(555499..556269) 1 NC_008258.1 Code: Q; COG: COG2977; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 556269 entD 4210109 entD Shigella flexneri 5 str. 8401 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_688092.1 555499 R 373384 CDS YP_688093.1 110804573 4210110 complement(556294..558534) 1 NC_008258.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 558534 fepA 4210110 fepA Shigella flexneri 5 str. 8401 outer membrane receptor FepA YP_688093.1 556294 R 373384 CDS YP_688094.1 110804574 4210111 558777..559979 1 NC_008258.1 Code: P; COG: COG2382; enterobactin/ferric enterobactin esterase 559979 fes 4210111 fes Shigella flexneri 5 str. 8401 enterobactin/ferric enterobactin esterase YP_688094.1 558777 D 373384 CDS YP_688095.1 110804575 4210112 559982..560200 1 NC_008258.1 Code: S; COG: COG3251; cytoplasmic protein 560200 ybdZ 4210112 ybdZ Shigella flexneri 5 str. 8401 cytoplasmic protein YP_688095.1 559982 D 373384 CDS YP_688096.1 110804576 4209463 560197..564090 1 NC_008258.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 564090 entF 4209463 entF Shigella flexneri 5 str. 8401 enterobactin synthase subunit F YP_688096.1 560197 D 373384 CDS YP_688097.1 110804577 4209464 complement(564102..564293) 1 NC_008258.1 IS1 encoded protein 564293 4209464 SFV_0533 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688097.1 564102 R 373384 CDS YP_688098.1 110804578 4209465 564368..564871 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 564871 insB 4209465 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688098.1 564368 D 373384 CDS YP_688099.1 110804579 4209467 complement(566212..567027) 1 NC_008258.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 567027 fepC 4209467 fepC Shigella flexneri 5 str. 8401 iron-enterobactin transporter ATP-binding protein YP_688099.1 566212 R 373384 CDS YP_688100.1 110804580 4209468 complement(567024..568016) 1 NC_008258.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 568016 fepG 4209468 fepG Shigella flexneri 5 str. 8401 iron-enterobactin transporter permease YP_688100.1 567024 R 373384 CDS YP_688101.1 110804581 4209469 complement(568013..569017) 1 NC_008258.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 569017 fepD 4209469 fepD Shigella flexneri 5 str. 8401 iron-enterobactin transporter membrane protein YP_688101.1 568013 R 373384 CDS YP_688102.1 110804582 4209470 569128..570360 1 NC_008258.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 570360 ybdA 4209470 ybdA Shigella flexneri 5 str. 8401 enterobactin exporter EntS YP_688102.1 569128 D 373384 CDS YP_688103.1 110804583 4209471 complement(570364..571320) 1 NC_008258.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin ABC transporter substrate-binding protein 571320 fepB 4209471 fepB Shigella flexneri 5 str. 8401 iron-enterobactin ABC transporter substrate-binding protein YP_688103.1 570364 R 373384 CDS YP_688104.1 110804584 4209473 572797..574407 1 NC_008258.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 574407 entE 4209473 entE Shigella flexneri 5 str. 8401 enterobactin synthase subunit E YP_688104.1 572797 D 373384 CDS YP_688105.1 110804585 4209474 574421..575278 1 NC_008258.1 Code: Q; COG: COG1535; 2,3-dihydro-2,3-dihydroxybenzoate synthetase 575278 entB 4209474 entB Shigella flexneri 5 str. 8401 2,3-dihydro-2,3-dihydroxybenzoate synthetase YP_688105.1 574421 D 373384 CDS YP_688106.1 110804586 4209475 575278..576024 1 NC_008258.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 576024 entA 4209475 entA Shigella flexneri 5 str. 8401 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_688106.1 575278 D 373384 CDS YP_688107.1 110804587 4209476 576027..576440 1 NC_008258.1 Code: Q; COG: COG2050; hypothetical protein 576440 ybdB 4209476 ybdB Shigella flexneri 5 str. 8401 hypothetical protein YP_688107.1 576027 D 373384 CDS YP_688108.1 110804588 4209477 576621..578726 1 NC_008258.1 Code: T; COG: COG1966; carbon starvation protein 578726 cstA 4209477 cstA Shigella flexneri 5 str. 8401 carbon starvation protein YP_688108.1 576621 D 373384 CDS YP_688109.1 110804589 4209478 578908..579105 1 NC_008258.1 Code: S; COG: COG2879; hypothetical protein 579105 ybdD 4209478 ybdD Shigella flexneri 5 str. 8401 hypothetical protein YP_688109.1 578908 D 373384 CDS YP_688110.1 110804590 4209479 complement(579115..580203) 1 NC_008258.1 member of the iron-containing alcohol dehydrogenase; unknown function; hypothetical protein 580203 ybdH 4209479 ybdH Shigella flexneri 5 str. 8401 hypothetical protein YP_688110.1 579115 R 373384 CDS YP_688111.1 110804591 4209480 580312..581472 1 NC_008258.1 catalyzes the transfer of an amino moiety; aminotransferase 581472 ybdL 4209480 ybdL Shigella flexneri 5 str. 8401 aminotransferase YP_688111.1 580312 D 373384 CDS YP_688112.1 110804592 4209481 complement(581473..581964) 1 NC_008258.1 Code: K; COG: COG1475; hypothetical protein 581964 ybdM 4209481 ybdM Shigella flexneri 5 str. 8401 hypothetical protein YP_688112.1 581473 R 373384 CDS YP_688113.1 110804593 4209482 complement(581992..582831) 1 NC_008258.1 Code: L; COG: COG2801; IS911 ORF2 582831 4209482 SFV_0551 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_688113.1 581992 R 373384 CDS YP_688114.1 110804594 4210636 complement(582858..583160) 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 583160 4210636 SFV_0552 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_688114.1 582858 R 373384 CDS YP_688115.1 110804595 4210637 complement(583327..583821) 1 NC_008258.1 hypothetical protein 583821 4210637 SFV_0553 Shigella flexneri 5 str. 8401 hypothetical protein YP_688115.1 583327 R 373384 CDS YP_688116.1 110804596 4210638 complement(583894..584304) 1 NC_008258.1 hypothetical protein 584304 4210638 SFV_0554 Shigella flexneri 5 str. 8401 hypothetical protein YP_688116.1 583894 R 373384 CDS YP_688117.1 110804597 4210639 584410..584688 1 NC_008258.1 Code: L; COG: COG2963; ISEhe3 orfA 584688 4210639 SFV_0555 Shigella flexneri 5 str. 8401 ISEhe3 orfA YP_688117.1 584410 D 373384 CDS YP_688118.1 110804598 4210640 584745..585557 1 NC_008258.1 Code: L; COG: COG2801; ISEhe3 orfB 585557 4210640 SFV_0556 Shigella flexneri 5 str. 8401 ISEhe3 orfB YP_688118.1 584745 D 373384 CDS YP_688119.1 110804599 4210641 complement(585926..586828) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 586828 ybdO 4210641 ybdO Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_688119.1 585926 R 373384 CDS YP_688120.1 110804600 4210642 complement(587038..587844) 1 NC_008258.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 587844 dsbG 4210642 dsbG Shigella flexneri 5 str. 8401 disulfide isomerase/thiol-disulfide oxidase YP_688120.1 587038 R 373384 CDS YP_688121.1 110804601 4210643 588156..588719 1 NC_008258.1 detoxification of hydroperoxides; with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 588719 ahpC 4210643 ahpC Shigella flexneri 5 str. 8401 alkyl hydroperoxide reductase YP_688121.1 588156 D 373384 CDS YP_688122.1 110804602 4210644 588964..590529 1 NC_008258.1 Code: O; COG: COG3634; alkyl hydroperoxide reductase 590529 ahpF 4210644 ahpF Shigella flexneri 5 str. 8401 alkyl hydroperoxide reductase YP_688122.1 588964 D 373384 CDS YP_688123.1 110804603 4210645 complement(590650..591078) 1 NC_008258.1 Code: T; COG: COG0589; hypothetical protein 591078 ybdQ 4210645 ybdQ Shigella flexneri 5 str. 8401 hypothetical protein YP_688123.1 590650 R 373384 CDS YP_688124.1 110804604 4210646 591299..592537 1 NC_008258.1 Code: ER; COG: COG1063; oxidoreductase 592537 ybdR 4210646 ybdR Shigella flexneri 5 str. 8401 oxidoreductase YP_688124.1 591299 D 373384 CDS YP_688125.1 110804605 4210647 complement(592768..593178) 1 NC_008258.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 593178 rnk 4210647 rnk Shigella flexneri 5 str. 8401 nucleoside diphosphate kinase regulator YP_688125.1 592768 R 373384 CDS YP_688126.1 110804606 4210648 complement(593407..594231) 1 NC_008258.1 cleaves phosphodiester bond between any two nucleotides; Code: J; COG: COG3719; ribonuclease I 594231 rna 4210648 rna Shigella flexneri 5 str. 8401 ribonuclease I YP_688126.1 593407 R 373384 CDS YP_688127.1 110804607 4210649 complement(594327..595790) 1 NC_008258.1 Code: P; COG: COG0471; hypothetical protein 595790 ybdS 4210649 ybdS Shigella flexneri 5 str. 8401 hypothetical protein YP_688127.1 594327 R 373384 CDS YP_688128.1 110804608 4210650 complement(595841..596719) 1 NC_008258.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 596719 citG 4210650 citG Shigella flexneri 5 str. 8401 triphosphoribosyl-dephospho-CoA synthase YP_688128.1 595841 R 373384 CDS YP_688129.1 110804609 4210651 complement(596694..597245) 1 NC_008258.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase 597245 citX 4210651 citX Shigella flexneri 5 str. 8401 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase YP_688129.1 596694 R 373384 CDS YP_688130.1 110804610 4210652 complement(597249..598823) 1 NC_008258.1 Code: C; COG: COG3051; citrate lyase subunit alpha 598823 citF 4210652 citF Shigella flexneri 5 str. 8401 citrate lyase subunit alpha YP_688130.1 597249 R 373384 CDS YP_688131.1 110804611 4210653 complement(598792..599700) 1 NC_008258.1 Code: G; COG: COG2301; citrate lyase subunit beta 599700 citE 4210653 citE Shigella flexneri 5 str. 8401 citrate lyase subunit beta YP_688131.1 598792 R 373384 CDS YP_688132.1 110804612 4210654 complement(599697..599993) 1 NC_008258.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 599993 citD 4210654 citD Shigella flexneri 5 str. 8401 citrate lyase subunit gamma YP_688132.1 599697 R 373384 CDS YP_688133.1 110804613 4210841 complement(601264..601767) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 601767 insB 4210841 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688133.1 601264 R 373384 CDS YP_688134.1 110804614 4210842 601881..602594 1 NC_008258.1 Code: L; COG: COG0582; integrase 602594 4210842 SFV_0573 Shigella flexneri 5 str. 8401 integrase YP_688134.1 601881 D 373384 CDS YP_688135.1 110804615 4210843 602728..603648 1 NC_008258.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 603648 ybhA 4210843 ybhA Shigella flexneri 5 str. 8401 phosphotransferase YP_688135.1 602728 D 373384 CDS YP_688136.1 110804616 4210844 complement(603649..604707) 1 NC_008258.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 604707 modC 4210844 modC Shigella flexneri 5 str. 8401 molybdate transporter ATP-binding protein YP_688136.1 603649 R 373384 CDS YP_688137.1 110804617 4210845 complement(604710..605399) 1 NC_008258.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 605399 modB 4210845 modB Shigella flexneri 5 str. 8401 molybdate ABC transporter permease YP_688137.1 604710 R 373384 CDS YP_688138.1 110804618 4210846 complement(605399..606172) 1 NC_008258.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate ABC transporter substrate-binding protein 606172 modA 4210846 modA Shigella flexneri 5 str. 8401 molybdate ABC transporter substrate-binding protein YP_688138.1 605399 R 373384 CDS YP_688139.1 110804619 4210847 complement(606339..606488) 1 NC_008258.1 hypothetical protein 606488 4210847 SFV_0578 Shigella flexneri 5 str. 8401 hypothetical protein YP_688139.1 606339 R 373384 CDS YP_688140.1 110804620 4210848 606617..607405 1 NC_008258.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 607405 modE 4210848 modE Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator ModE YP_688140.1 606617 D 373384 CDS YP_688141.1 110804621 4210849 607473..608945 1 NC_008258.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 608945 modF 4210849 modF Shigella flexneri 5 str. 8401 molybdenum transport ATP-binding protein ModF YP_688141.1 607473 D 373384 CDS YP_688142.1 110804622 4210850 609206..610222 1 NC_008258.1 Code: M; COG: COG1087; UDP-galactose-4-epimerase 610222 galE 4210850 galE Shigella flexneri 5 str. 8401 UDP-galactose-4-epimerase YP_688142.1 609206 D 373384 CDS YP_688143.1 110804623 4210851 610232..611278 1 NC_008258.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 611278 galT 4210851 galT Shigella flexneri 5 str. 8401 galactose-1-phosphate uridylyltransferase YP_688143.1 610232 D 373384 CDS YP_688144.1 110804624 4210852 611282..612430 1 NC_008258.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 612430 galK 4210852 galK Shigella flexneri 5 str. 8401 galactokinase YP_688144.1 611282 D 373384 CDS YP_688145.1 110804625 4210853 612424..613464 1 NC_008258.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 613464 galM 4210853 galM Shigella flexneri 5 str. 8401 aldose 1-epimerase YP_688145.1 612424 D 373384 CDS YP_688146.1 110804626 4210854 613667..614419 1 NC_008258.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 614419 gpmA 4210854 gpmA Shigella flexneri 5 str. 8401 phosphoglyceromutase YP_688146.1 613667 D 373384 CDS YP_688147.1 110804627 4210855 complement(614586..615638) 1 NC_008258.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 615638 aroG 4210855 aroG Shigella flexneri 5 str. 8401 phospho-2-dehydro-3-deoxyheptonate aldolase YP_688147.1 614586 R 373384 CDS YP_688148.1 110804628 4210856 615954..616334 1 NC_008258.1 homeobox protein 616334 4210856 SFV_0587 Shigella flexneri 5 str. 8401 homeobox protein YP_688148.1 615954 D 373384 CDS YP_688149.1 110804629 4210857 616448..617389 1 NC_008258.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 617389 ybgR 4210857 ybgR Shigella flexneri 5 str. 8401 zinc transporter ZitB YP_688149.1 616448 D 373384 CDS YP_688150.1 110804630 4210858 complement(617386..618105) 1 NC_008258.1 Code: H; COG: COG3201; PnuC protein 618105 pnuC 4210858 pnuC Shigella flexneri 5 str. 8401 PnuC protein YP_688150.1 617386 R 373384 CDS YP_688151.1 110804631 4210859 complement(618143..619186) 1 NC_008258.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 619186 nadA 4210859 nadA Shigella flexneri 5 str. 8401 quinolinate synthetase YP_688151.1 618143 R 373384 CDS YP_688152.1 110804632 4210827 complement(619965..620756) 1 NC_008258.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 620756 ybgF 4210827 ybgF Shigella flexneri 5 str. 8401 tol-pal system protein YbgF YP_688152.1 619965 R 373384 CDS YP_688153.1 110804633 4210828 complement(620766..621287) 1 NC_008258.1 Code: M; COG: COG2885; peptidoglycan-associated outer membrane lipoprotein 621287 pal 4210828 pal Shigella flexneri 5 str. 8401 peptidoglycan-associated outer membrane lipoprotein YP_688153.1 620766 R 373384 CDS YP_688154.1 110804634 4210829 complement(621322..622614) 1 NC_008258.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 622614 tolB 4210829 tolB Shigella flexneri 5 str. 8401 translocation protein TolB YP_688154.1 621322 R 373384 CDS YP_688155.1 110804635 4210830 complement(622747..623988) 1 NC_008258.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 623988 tolA 4210830 tolA Shigella flexneri 5 str. 8401 cell envelope integrity inner membrane protein TolA YP_688155.1 622747 R 373384 CDS YP_688156.1 110804636 4210831 complement(624053..624481) 1 NC_008258.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 624481 tolR 4210831 tolR Shigella flexneri 5 str. 8401 colicin uptake protein TolR YP_688156.1 624053 R 373384 CDS YP_688157.1 110804637 4210832 complement(624485..625168) 1 NC_008258.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 625168 tolQ 4210832 tolQ Shigella flexneri 5 str. 8401 colicin uptake protein TolQ YP_688157.1 624485 R 373384 CDS YP_688158.1 110804638 4210833 complement(625174..625578) 1 NC_008258.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 625578 ybgC 4210833 ybgC Shigella flexneri 5 str. 8401 acyl-CoA thioester hydrolase YP_688158.1 625174 R 373384 CDS YP_688159.1 110804639 4210834 complement(625728..626021) 1 NC_008258.1 Code: S; COG: COG3790; hypothetical protein 626021 ybgE 4210834 ybgE Shigella flexneri 5 str. 8401 hypothetical protein YP_688159.1 625728 R 373384 CDS YP_688160.1 110804640 4210835 complement(626149..627288) 1 NC_008258.1 Code: C; COG: COG1294; cytochrome d terminal oxidase polypeptide subunit II 627288 cydB 4210835 cydB Shigella flexneri 5 str. 8401 cytochrome d terminal oxidase polypeptide subunit II YP_688160.1 626149 R 373384 CDS YP_688161.1 110804641 4210836 complement(627304..628872) 1 NC_008258.1 Code: C; COG: COG1271; cytochrome d terminal oxidase, polypeptide subunit I 628872 cydA 4210836 cydA Shigella flexneri 5 str. 8401 cytochrome d terminal oxidase, polypeptide subunit I YP_688161.1 627304 R 373384 CDS YP_688162.1 110804642 4210837 complement(629722..632355) 1 NC_008258.1 Code: G; COG: COG0383; alpha-mannosidase 632355 ybgG 4210837 ybgG Shigella flexneri 5 str. 8401 alpha-mannosidase YP_688162.1 629722 R 373384 CDS YP_688163.1 110804643 4210839 634459..635181 1 NC_008258.1 regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 635181 farR 4210839 farR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor MngR YP_688163.1 634459 D 373384 CDS YP_688164.1 110804644 4207361 complement(635284..636153) 1 NC_008258.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 636153 sucD 4207361 sucD Shigella flexneri 5 str. 8401 succinyl-CoA synthetase subunit alpha YP_688164.1 635284 R 373384 CDS YP_688165.1 110804645 4207362 complement(636153..637319) 1 NC_008258.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 637319 sucC 4207362 sucC Shigella flexneri 5 str. 8401 succinyl-CoA synthetase subunit beta YP_688165.1 636153 R 373384 CDS YP_688166.1 110804646 4207363 complement(637413..638630) 1 NC_008258.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 638630 sucB 4207363 sucB Shigella flexneri 5 str. 8401 dihydrolipoamide succinyltransferase YP_688166.1 637413 R 373384 CDS YP_688167.1 110804647 4207364 complement(638645..641446) 1 NC_008258.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 641446 sucA 4207364 sucA Shigella flexneri 5 str. 8401 2-oxoglutarate dehydrogenase E1 YP_688167.1 638645 R 373384 CDS YP_688168.1 110804648 4207365 complement(641747..642463) 1 NC_008258.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 642463 sdhB 4207365 sdhB Shigella flexneri 5 str. 8401 succinate dehydrogenase iron-sulfur subunit YP_688168.1 641747 R 373384 CDS YP_688169.1 110804649 4207366 complement(642479..644245) 1 NC_008258.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 644245 sdhA 4207366 sdhA Shigella flexneri 5 str. 8401 succinate dehydrogenase flavoprotein subunit YP_688169.1 642479 R 373384 CDS YP_688170.1 110804650 4207367 complement(644245..644592) 1 NC_008258.1 Code: C; COG: COG2142; succinate dehydrogenase cytochrome b556 small membrane subunit 644592 sdhD 4207367 sdhD Shigella flexneri 5 str. 8401 succinate dehydrogenase cytochrome b556 small membrane subunit YP_688170.1 644245 R 373384 CDS YP_688171.1 110804651 4207368 complement(644586..644975) 1 NC_008258.1 Code: C; COG: COG2009; succinate dehydrogenase cytochrome b556 large membrane subunit 644975 sdhC 4207368 sdhC Shigella flexneri 5 str. 8401 succinate dehydrogenase cytochrome b556 large membrane subunit YP_688171.1 644586 R 373384 CDS YP_688172.1 110804652 4207369 645684..646967 1 NC_008258.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 646967 gltA 4207369 gltA Shigella flexneri 5 str. 8401 type II citrate synthase YP_688172.1 645684 D 373384 CDS YP_688173.1 110804653 4207370 647357..647923 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 647923 ybgD 4207370 ybgD Shigella flexneri 5 str. 8401 fimbrial-like protein YP_688173.1 647357 D 373384 CDS YP_688174.1 110804654 4207371 647932..650433 1 NC_008258.1 Code: NU; COG: COG3188; outer membrane protein 650433 ybgQ 4207371 ybgQ Shigella flexneri 5 str. 8401 outer membrane protein YP_688174.1 647932 D 373384 CDS YP_688175.1 110804655 4207372 650448..651179 1 NC_008258.1 Code: NU; COG: COG3121; chaperone 651179 ybgP 4207372 ybgP Shigella flexneri 5 str. 8401 chaperone YP_688175.1 650448 D 373384 CDS YP_688176.1 110804656 4207373 651512..652252 1 NC_008258.1 hypothetical protein 652252 ybgO 4207373 ybgO Shigella flexneri 5 str. 8401 hypothetical protein YP_688176.1 651512 D 373384 CDS YP_688177.1 110804657 4207375 complement(653447..654238) 1 NC_008258.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 654238 nei 4207375 nei Shigella flexneri 5 str. 8401 endonuclease VIII YP_688177.1 653447 R 373384 CDS YP_688178.1 110804658 4207376 complement(654274..655008) 1 NC_008258.1 Code: R; COG: COG1540; LamB/YcsF family protein 655008 ybgL 4207376 ybgL Shigella flexneri 5 str. 8401 LamB/YcsF family protein YP_688178.1 654274 R 373384 CDS YP_688179.1 110804659 4207378 complement(655924..656580) 1 NC_008258.1 Code: E; COG: COG2049; carboxylase 656580 ybgJ 4207378 ybgJ Shigella flexneri 5 str. 8401 carboxylase YP_688179.1 655924 R 373384 CDS YP_688180.1 110804660 4207379 complement(656603..657346) 1 NC_008258.1 Code: S; COG: COG0327; hydrolase-oxidase 657346 ybgI 4207379 ybgI Shigella flexneri 5 str. 8401 hydrolase-oxidase YP_688180.1 656603 R 373384 CDS YP_688181.1 110804661 4207380 657617..659098 1 NC_008258.1 Code: E; COG: COG3104; transport protein 659098 ybgH 4207380 ybgH Shigella flexneri 5 str. 8401 transport protein YP_688181.1 657617 D 373384 CDS YP_688182.1 110804662 4210655 complement(659248..660666) 1 NC_008258.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 660666 phrB 4210655 phrB Shigella flexneri 5 str. 8401 deoxyribodipyrimidine photolyase YP_688182.1 659248 R 373384 CDS YP_688183.1 110804663 4210656 complement(660663..661172) 1 NC_008258.1 Code: S; COG: COG3272; hypothetical protein 661172 ybgA 4210656 ybgA Shigella flexneri 5 str. 8401 hypothetical protein YP_688183.1 660663 R 373384 CDS YP_688184.1 110804664 4210657 661301..661588 1 NC_008258.1 hypothetical protein 661588 4210657 SFV_0629 Shigella flexneri 5 str. 8401 hypothetical protein YP_688184.1 661301 D 373384 CDS YP_688185.1 110804665 4210658 complement(662026..666690) 1 NC_008258.1 Code: M; COG: COG3209; Rhs family protein 666690 4210658 SFV_0630 Shigella flexneri 5 str. 8401 Rhs family protein YP_688185.1 662026 R 373384 CDS YP_688186.1 110804666 4210659 complement(666709..666909) 1 NC_008258.1 hypothetical protein 666909 4210659 SFV_0631 Shigella flexneri 5 str. 8401 hypothetical protein YP_688186.1 666709 R 373384 CDS YP_688187.1 110804667 4210660 complement(667306..667809) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 667809 insB 4210660 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688187.1 667306 R 373384 CDS YP_688188.1 110804668 4210661 667884..668099 1 NC_008258.1 IS1 encoded protein 668099 4210661 SFV_0633 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688188.1 667884 D 373384 CDS YP_688189.1 110804669 4210662 complement(668497..668703) 1 NC_008258.1 hypothetical protein 668703 ybfA 4210662 ybfA Shigella flexneri 5 str. 8401 hypothetical protein YP_688189.1 668497 R 373384 CDS YP_688190.1 110804670 4210663 669105..670754 1 NC_008258.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 670754 kdpA 4210663 kdpA Shigella flexneri 5 str. 8401 potassium-transporting ATPase subunit A YP_688190.1 669105 D 373384 CDS YP_688191.1 110804671 4210665 672833..673405 1 NC_008258.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 673405 kdpC 4210665 kdpC Shigella flexneri 5 str. 8401 potassium-transporting ATPase subunit C YP_688191.1 672833 D 373384 CDS YP_688192.1 110804672 4210667 676153..676755 1 NC_008258.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 676755 kdpE 4210667 kdpE Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator KdpE YP_688192.1 676153 D 373384 CDS YP_688193.1 110804673 4210668 complement(676777..676911) 1 NC_008258.1 hypothetical protein 676911 4210668 SFV_0640 Shigella flexneri 5 str. 8401 hypothetical protein YP_688193.1 676777 R 373384 CDS YP_688194.1 110804674 4210670 679639..680958 1 NC_008258.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 680958 potE 4210670 potE Shigella flexneri 5 str. 8401 putrescine transporter YP_688194.1 679639 D 373384 CDS YP_688195.1 110804675 4210671 complement(681014..682654) 1 NC_008258.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 682654 pgm 4210671 pgm Shigella flexneri 5 str. 8401 phosphoglucomutase YP_688195.1 681014 R 373384 CDS YP_688196.1 110804676 4210672 complement(682680..683258) 1 NC_008258.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 683258 seqA 4210672 seqA Shigella flexneri 5 str. 8401 replication initiation regulator SeqA YP_688196.1 682680 R 373384 CDS YP_688197.1 110804677 4210673 683411..684175 1 NC_008258.1 Code: R; COG: COG0596; hypothetical protein 684175 ybfF 4210673 ybfF Shigella flexneri 5 str. 8401 hypothetical protein YP_688197.1 683411 D 373384 CDS YP_688198.1 110804678 4210694 684246..684608 1 NC_008258.1 LexA regulated protein 684608 ybfE 4210694 ybfE Shigella flexneri 5 str. 8401 LexA regulated protein YP_688198.1 684246 D 373384 CDS YP_688199.1 110804679 4210695 684631..685278 1 NC_008258.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 685278 fldA 4210695 fldA Shigella flexneri 5 str. 8401 flavodoxin FldA YP_688199.1 684631 D 373384 CDS YP_688200.1 110804680 4210696 685568..686014 1 NC_008258.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 686014 fur 4210696 fur Shigella flexneri 5 str. 8401 ferric uptake regulator YP_688200.1 685568 D 373384 CDS YP_688201.1 110804681 4210697 complement(686098..686442) 1 NC_008258.1 hypothetical protein 686442 ybfN 4210697 ybfN Shigella flexneri 5 str. 8401 hypothetical protein YP_688201.1 686098 R 373384 CDS YP_688202.1 110804682 4210698 complement(686461..687867) 1 NC_008258.1 hypothetical protein 687867 ybfM 4210698 ybfM Shigella flexneri 5 str. 8401 hypothetical protein YP_688202.1 686461 R 373384 CDS YP_688203.1 110804683 4210699 complement(688446..690110) 1 NC_008258.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 690110 glnS 4210699 glnS Shigella flexneri 5 str. 8401 glutaminyl-tRNA synthetase YP_688203.1 688446 R 373384 CDS YP_688204.1 110804684 4210700 complement(690313..692259) 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunits IIABC 692259 nagE 4210700 nagE Shigella flexneri 5 str. 8401 PTS system N-acetyl glucosamine specific transporter subunits IIABC YP_688204.1 690313 R 373384 CDS YP_688205.1 110804685 4210701 692592..693392 1 NC_008258.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 693392 nagB 4210701 nagB Shigella flexneri 5 str. 8401 glucosamine-6-phosphate deaminase YP_688205.1 692592 D 373384 CDS YP_688206.1 110804686 4210702 693452..694600 1 NC_008258.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 694600 nagA 4210702 nagA Shigella flexneri 5 str. 8401 N-acetylglucosamine-6-phosphate deacetylase YP_688206.1 693452 D 373384 CDS YP_688207.1 110804687 4210703 694609..695829 1 NC_008258.1 Code: KG; COG: COG1940; transcriptional repressor of nag (N-acetylglucosamine) operon 695829 nagC 4210703 nagC Shigella flexneri 5 str. 8401 transcriptional repressor of nag (N-acetylglucosamine) operon YP_688207.1 694609 D 373384 CDS YP_688208.1 110804688 4210704 695877..696629 1 NC_008258.1 Code: G; COG: COG0647; UMP phosphatase 696629 nagD 4210704 nagD Shigella flexneri 5 str. 8401 UMP phosphatase YP_688208.1 695877 D 373384 CDS YP_688209.1 110804689 4210705 697026..698690 1 NC_008258.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 698690 asnB 4210705 asnB Shigella flexneri 5 str. 8401 asparagine synthetase B YP_688209.1 697026 D 373384 CDS YP_688210.1 110804690 4209715 complement(699929..701104) 1 NC_008258.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 701104 ubiF 4209715 ubiF Shigella flexneri 5 str. 8401 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_688210.1 699929 R 373384 CDS YP_688211.1 110804691 4209716 701250..702674 1 NC_008258.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 702674 yleA 4209716 yleA Shigella flexneri 5 str. 8401 (dimethylallyl)adenosine tRNA methylthiotransferase YP_688211.1 701250 D 373384 CDS YP_688212.1 110804692 4209717 702827..703867 1 NC_008258.1 Code: T; COG: COG1702; ATP-binding protein in pho regulon 703867 ybeZ 4209717 ybeZ Shigella flexneri 5 str. 8401 ATP-binding protein in pho regulon YP_688212.1 702827 D 373384 CDS YP_688213.1 110804693 4209718 703864..704331 1 NC_008258.1 Code: R; COG: COG0319; metalloprotease 704331 ybeY 4209718 ybeY Shigella flexneri 5 str. 8401 metalloprotease YP_688213.1 703864 D 373384 CDS YP_688214.1 110804694 4209719 704421..705299 1 NC_008258.1 Code: P; COG: COG4535; transport protein 705299 ybeX 4209719 ybeX Shigella flexneri 5 str. 8401 transport protein YP_688214.1 704421 D 373384 CDS YP_688215.1 110804695 4209720 705324..706862 1 NC_008258.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 706862 lnt 4209720 lnt Shigella flexneri 5 str. 8401 apolipoprotein N-acyltransferase YP_688215.1 705324 D 373384 CDS YP_688216.1 110804696 4209721 707259..708167 1 NC_008258.1 Code: ET; COG: COG0834; glutamate and aspartate transporter subunit 708167 ybeJ 4209721 ybeJ Shigella flexneri 5 str. 8401 glutamate and aspartate transporter subunit YP_688216.1 707259 D 373384 CDS YP_688217.1 110804697 4209722 708337..709077 1 NC_008258.1 Code: E; COG: COG0765; glutamate/aspartate transport system permease 709077 gltJ 4209722 gltJ Shigella flexneri 5 str. 8401 glutamate/aspartate transport system permease YP_688217.1 708337 D 373384 CDS YP_688218.1 110804698 4209723 709077..709751 1 NC_008258.1 Code: E; COG: COG0765; glutamate/aspartate transport system permease 709751 gltK 4209723 gltK Shigella flexneri 5 str. 8401 glutamate/aspartate transport system permease YP_688218.1 709077 D 373384 CDS YP_688219.1 110804699 4209724 709751..710476 1 NC_008258.1 Code: E; COG: COG1126; ATP-binding protein of glutamate/aspartate transport system 710476 gltL 4209724 gltL Shigella flexneri 5 str. 8401 ATP-binding protein of glutamate/aspartate transport system YP_688219.1 709751 D 373384 CDS YP_688220.1 110804700 4209725 710594..711529 1 NC_008258.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 711529 rihA 4209725 rihA Shigella flexneri 5 str. 8401 ribonucleoside hydrolase 1 YP_688220.1 710594 D 373384 CDS YP_688221.1 110804701 4209726 711613..713283 1 NC_008258.1 Code: O; COG: COG0443; molecular chaperone DnaK 713283 ybeW 4209726 ybeW Shigella flexneri 5 str. 8401 molecular chaperone DnaK YP_688221.1 711613 D 373384 CDS YP_688222.1 110804702 4209920 complement(713343..714794) 1 NC_008258.1 hypothetical protein 714794 ybeV 4209920 ybeV Shigella flexneri 5 str. 8401 hypothetical protein YP_688222.1 713343 R 373384 CDS YP_688223.1 110804703 4209921 complement(714791..715498) 1 NC_008258.1 tRNA ligase 715498 ybeU 4209921 ybeU Shigella flexneri 5 str. 8401 tRNA ligase YP_688223.1 714791 R 373384 CDS YP_688224.1 110804704 4209922 715600..716154 1 NC_008258.1 Code: R; COG: COG0790; hypothetical protein 716154 ybeT 4209922 ybeT Shigella flexneri 5 str. 8401 hypothetical protein YP_688224.1 715600 D 373384 CDS YP_688225.1 110804705 4209923 complement(716164..717591) 1 NC_008258.1 polynucleotide modification protein 717591 ybeS 4209923 ybeS Shigella flexneri 5 str. 8401 polynucleotide modification protein YP_688225.1 716164 R 373384 CDS YP_688226.1 110804706 4209924 complement(717588..718295) 1 NC_008258.1 hypothetical protein 718295 ybeR 4209924 ybeR Shigella flexneri 5 str. 8401 hypothetical protein YP_688226.1 717588 R 373384 CDS YP_688227.1 110804707 4209925 718459..719436 1 NC_008258.1 Code: R; COG: COG0790; hypothetical protein 719436 ybeQ 4209925 ybeQ Shigella flexneri 5 str. 8401 hypothetical protein YP_688227.1 718459 D 373384 CDS YP_688228.1 110804708 4209926 complement(719506..719988) 1 NC_008258.1 hypothetical protein 719988 ybeL 4209926 ybeL Shigella flexneri 5 str. 8401 hypothetical protein YP_688228.1 719506 R 373384 CDS YP_688229.1 110804709 4209927 720130..722805 1 NC_008258.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 722805 leuS 4209927 leuS Shigella flexneri 5 str. 8401 leucyl-tRNA synthetase YP_688229.1 720130 D 373384 CDS YP_688230.1 110804710 4209928 722820..723401 1 NC_008258.1 a minor lipoprotein; rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 723401 rlpB 4209928 rlpB Shigella flexneri 5 str. 8401 LPS-assembly lipoprotein RlpB YP_688230.1 722820 D 373384 CDS YP_688231.1 110804711 4209929 723401..724432 1 NC_008258.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 724432 holA 4209929 holA Shigella flexneri 5 str. 8401 DNA polymerase III subunit delta YP_688231.1 723401 D 373384 CDS YP_688232.1 110804712 4209930 724434..725075 1 NC_008258.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 725075 nadD 4209930 nadD Shigella flexneri 5 str. 8401 nicotinic acid mononucleotide adenylyltransferase YP_688232.1 724434 D 373384 CDS YP_688233.1 110804713 4209931 725099..725710 1 NC_008258.1 a phosphohistidine protein; Code: G; COG: COG0406; phosphohistidine protein PhpB 725710 phpB 4209931 phpB Shigella flexneri 5 str. 8401 phosphohistidine protein PhpB YP_688233.1 725099 D 373384 CDS YP_688234.1 110804714 4209932 725970..726287 1 NC_008258.1 Code: S; COG: COG0799; hypothetical protein 726287 ybeB 4209932 ybeB Shigella flexneri 5 str. 8401 hypothetical protein YP_688234.1 725970 D 373384 CDS YP_688235.1 110804715 4209933 726291..726758 1 NC_008258.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 726758 ybeA 4209933 ybeA Shigella flexneri 5 str. 8401 rRNA large subunit methyltransferase YP_688235.1 726291 D 373384 CDS YP_688236.1 110804716 4209934 726789..728690 1 NC_008258.1 Code: M; COG: COG0768; penicillin-binding protein 2 728690 mrdA 4209934 mrdA Shigella flexneri 5 str. 8401 penicillin-binding protein 2 YP_688236.1 726789 D 373384 CDS YP_688237.1 110804717 4209935 728693..729805 1 NC_008258.1 Code: D; COG: COG0772; cell wall shape-determining protein 729805 mrdB 4209935 mrdB Shigella flexneri 5 str. 8401 cell wall shape-determining protein YP_688237.1 728693 D 373384 CDS YP_688238.1 110804718 4209936 729816..730904 1 NC_008258.1 a minor lipoprotein; Code: M; COG: COG0797; rare lipoprotein A 730904 rlpA 4209936 rlpA Shigella flexneri 5 str. 8401 rare lipoprotein A YP_688238.1 729816 D 373384 CDS YP_688239.1 110804719 4209937 730971..732254 1 NC_008258.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase fraction A 732254 dacA 4209937 dacA Shigella flexneri 5 str. 8401 D-alanyl-D-alanine carboxypeptidase fraction A YP_688239.1 730971 D 373384 CDS YP_688240.1 110804720 4209938 732365..732628 1 NC_008258.1 Code: S; COG: COG2921; hypothetical protein 732628 ybeD 4209938 ybeD Shigella flexneri 5 str. 8401 hypothetical protein YP_688240.1 732365 D 373384 CDS YP_688241.1 110804721 4209939 732729..733370 1 NC_008258.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 733370 lipB 4209939 lipB Shigella flexneri 5 str. 8401 lipoate-protein ligase B YP_688241.1 732729 D 373384 CDS YP_688242.1 110804722 4209940 733629..734582 1 NC_008258.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 734582 ybeF 4209940 ybeF Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_688242.1 733629 D 373384 CDS YP_688243.1 110804723 4209941 734806..735756 1 NC_008258.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 735756 lipA 4209941 lipA Shigella flexneri 5 str. 8401 lipoyl synthase YP_688243.1 734806 D 373384 CDS YP_688244.1 110804724 4209942 complement(735857..736060) 1 NC_008258.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase E 736060 tatE 4209942 tatE Shigella flexneri 5 str. 8401 twin arginine translocase E YP_688244.1 735857 R 373384 CDS YP_688245.1 110804725 4209943 complement(736189..736977) 1 NC_008258.1 Code: R; COG: COG0388; amidase 736977 ybeM 4209943 ybeM Shigella flexneri 5 str. 8401 amidase YP_688245.1 736189 R 373384 CDS YP_688246.1 110804726 4209944 737070..737453 1 NC_008258.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 737453 crcB 4209944 crcB Shigella flexneri 5 str. 8401 camphor resistance protein CrcB YP_688246.1 737070 D 373384 CDS YP_688247.1 110804727 4209945 complement(737507..737800) 1 NC_008258.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 737800 cspE 4209945 cspE Shigella flexneri 5 str. 8401 cold shock protein CspE YP_688247.1 737507 R 373384 CDS YP_688248.1 110804728 4209946 complement(737891..738475) 1 NC_008258.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 738475 pagP 4209946 pagP Shigella flexneri 5 str. 8401 palmitoyl transferase YP_688248.1 737891 R 373384 CDS YP_688249.1 110804729 4209947 739040..740425 1 NC_008258.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 740425 dcuC 4209947 dcuC Shigella flexneri 5 str. 8401 C4-dicarboxylate transporter DcuC YP_688249.1 739040 D 373384 CDS YP_688250.1 110804730 4209949 complement(741145..741654) 1 NC_008258.1 repressor protein 741654 4209949 SFV_0706 Shigella flexneri 5 str. 8401 repressor protein YP_688250.1 741145 R 373384 CDS YP_688251.1 110804731 4209950 742037..743671 1 NC_008258.1 Code: L; COG: COG2801; phage transposase 743671 4209950 SFV_0707 Shigella flexneri 5 str. 8401 phage transposase YP_688251.1 742037 D 373384 CDS YP_688252.1 110804732 4209951 743733..744035 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 744035 4209951 SFV_0708 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688252.1 743733 D 373384 CDS YP_688253.1 110804733 4209952 744176..744889 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 744889 4209952 SFV_0709 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688253.1 744176 D 373384 CDS YP_688254.1 110804734 4209953 complement(745173..746114) 1 NC_008258.1 bacteriophage protein 746114 4209953 SFV_0710 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688254.1 745173 R 373384 CDS YP_688255.1 110804735 4209954 complement(746126..746632) 1 NC_008258.1 bacteriophage protein 746632 4209954 SFV_0711 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688255.1 746126 R 373384 CDS YP_688256.1 110804736 4209955 complement(746636..747856) 1 NC_008258.1 bacteriophage protein 747856 4209955 SFV_0712 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688256.1 746636 R 373384 CDS YP_688257.1 110804737 4209956 complement(748494..749960) 1 NC_008258.1 bacteriophage protein 749960 4209956 SFV_0713 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688257.1 748494 R 373384 CDS YP_688258.1 110804738 4209957 complement(749960..750727) 1 NC_008258.1 bacteriophage protein 750727 4209957 SFV_0714 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688258.1 749960 R 373384 CDS YP_688259.1 110804739 4209958 complement(750712..751551) 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 751551 4209958 SFV_0715 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_688259.1 750712 R 373384 CDS YP_688260.1 110804740 4207192 complement(751575..751940) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 751940 4207192 SFV_0716 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688260.1 751575 R 373384 CDS YP_688261.1 110804741 4207193 complement(752016..752717) 1 NC_008258.1 bacteriophage protein 752717 4207193 SFV_0717 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688261.1 752016 R 373384 CDS YP_688262.1 110804742 4207194 complement(752650..753414) 1 NC_008258.1 bacteriophage protein 753414 4207194 SFV_0718 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688262.1 752650 R 373384 CDS YP_688263.1 110804743 4207195 754528..754830 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 754830 4207195 SFV_0719 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_688263.1 754528 D 373384 CDS YP_688264.1 110804744 4207196 755131..755697 1 NC_008258.1 IS911 ORF2 755697 4207196 SFV_0720 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_688264.1 755131 D 373384 CDS YP_688265.1 110804745 4207197 complement(755703..755951) 1 NC_008258.1 endopeptidase 755951 4207197 SFV_0721 Shigella flexneri 5 str. 8401 endopeptidase YP_688265.1 755703 R 373384 CDS YP_688266.1 110804746 4207198 complement(755936..756202) 1 NC_008258.1 IS2 ORF2 756202 4207198 SFV_0722 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_688266.1 755936 R 373384 CDS YP_688267.1 110804747 4207199 complement(756237..757838) 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF3 757838 4207199 SFV_0723 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_688267.1 756237 R 373384 CDS YP_688268.1 110804748 4207200 complement(757858..758205) 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 758205 4207200 SFV_0724 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_688268.1 757858 R 373384 CDS YP_688269.1 110804749 4207201 complement(758202..758876) 1 NC_008258.1 ISSfl4 ORF1 758876 4207201 SFV_0725 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_688269.1 758202 R 373384 CDS YP_688270.1 110804750 4207202 complement(758930..759445) 1 NC_008258.1 Code: R; COG: COG3772; bacteriophage lambda lysozyme 759445 ybcS 4207202 ybcS Shigella flexneri 5 str. 8401 bacteriophage lambda lysozyme YP_688270.1 758930 R 373384 CDS YP_688271.1 110804751 4207203 759638..759940 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 759940 4207203 SFV_0727 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688271.1 759638 D 373384 CDS YP_688272.1 110804752 4207204 760081..760794 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 760794 4207204 SFV_0728 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688272.1 760081 D 373384 CDS YP_688273.1 110804753 4207401 complement(762658..762948) 1 NC_008258.1 bacteriophage protein 762948 4207401 SFV_0733 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688273.1 762658 R 373384 CDS YP_688274.1 110804754 4207402 complement(762948..763547) 1 NC_008258.1 prophage protein 763547 4207402 SFV_0734 Shigella flexneri 5 str. 8401 prophage protein YP_688274.1 762948 R 373384 CDS YP_688275.1 110804755 4207403 complement(763586..763873) 1 NC_008258.1 hypothetical protein 763873 4207403 SFV_0735 Shigella flexneri 5 str. 8401 hypothetical protein YP_688275.1 763586 R 373384 CDS YP_688276.1 110804756 4207404 complement(764506..765192) 1 NC_008258.1 Code: S; COG: COG1636; hypothetical protein 765192 4207404 SFV_0736 Shigella flexneri 5 str. 8401 hypothetical protein YP_688276.1 764506 R 373384 CDS YP_688277.1 110804757 4207405 complement(765340..765696) 1 NC_008258.1 bacteriophage protein 765696 4207405 SFV_0737 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688277.1 765340 R 373384 CDS YP_688278.1 110804758 4207407 complement(767083..767721) 1 NC_008258.1 bacteriophage protein 767721 4207407 SFV_0739 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688278.1 767083 R 373384 CDS YP_688279.1 110804759 4207408 complement(767799..768104) 1 NC_008258.1 bacteriophage protein 768104 ydaT 4207408 ydaT Shigella flexneri 5 str. 8401 bacteriophage protein YP_688279.1 767799 R 373384 CDS YP_688280.1 110804760 4207409 complement(768206..768433) 1 NC_008258.1 DNA-binding transcriptional regulator DicC 768433 4207409 SFV_0741 Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator DicC YP_688280.1 768206 R 373384 CDS YP_688281.1 110804761 4207410 769276..769479 1 NC_008258.1 hypothetical protein 769479 4207410 SFV_0742 Shigella flexneri 5 str. 8401 hypothetical protein YP_688281.1 769276 D 373384 CDS YP_688282.2 162139354 4207411 complement(769721..770626) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 770626 4207411 SFV_0743 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_688282.2 769721 R 373384 CDS YP_688283.1 110804763 4207412 complement(770584..770949) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 770949 4207412 SFV_0744 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688283.1 770584 R 373384 CDS YP_688284.1 110804764 4207413 771497..772345 1 NC_008258.1 bacteriophage protein 772345 4207413 SFV_0745 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688284.1 771497 D 373384 CDS YP_688285.1 110804765 4207414 complement(772838..773551) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 773551 4207414 SFV_0746 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688285.1 772838 R 373384 CDS YP_688286.1 110804766 4207415 complement(773692..773994) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 773994 4207415 SFV_0747 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688286.1 773692 R 373384 CDS YP_688287.1 110804767 4207416 774060..774677 1 NC_008258.1 hypothetical protein 774677 4207416 SFV_0748 Shigella flexneri 5 str. 8401 hypothetical protein YP_688287.1 774060 D 373384 CDS YP_688288.1 110804768 4207417 complement(774857..776683) 1 NC_008258.1 Code: S; COG: COG4886; invasion plasmid antigen 776683 ipaH_1 4207417 ipaH_1 Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_688288.1 774857 R 373384 CDS YP_688289.1 110804769 4207418 777565..778560 1 NC_008258.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 778560 ybhE 4207418 ybhE Shigella flexneri 5 str. 8401 6-phosphogluconolactonase YP_688289.1 777565 D 373384 CDS YP_688290.1 110804770 4207324 779738..780790 1 NC_008258.1 Code: S; COG: COG2828; hypothetical protein 780790 ybhH 4207324 ybhH Shigella flexneri 5 str. 8401 hypothetical protein YP_688290.1 779738 D 373384 CDS YP_688291.1 110804771 4207325 780866..782299 1 NC_008258.1 Code: P; COG: COG0471; membrane pump protein 782299 ybhI 4207325 ybhI Shigella flexneri 5 str. 8401 membrane pump protein YP_688291.1 780866 D 373384 CDS YP_688292.1 110804772 4207326 782482..784662 1 NC_008258.1 Code: C; COG: COG1048; hypothetical protein 784662 ybhJ 4207326 ybhJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688292.1 782482 D 373384 CDS YP_688293.1 110804773 4207327 complement(784803..786086) 1 NC_008258.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase; pectinesterase 786086 ybhC 4207327 ybhC Shigella flexneri 5 str. 8401 pectinesterase YP_688293.1 784803 R 373384 CDS YP_688294.1 110804774 4207328 complement(786238..786714) 1 NC_008258.1 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 786714 ybhB 4207328 ybhB Shigella flexneri 5 str. 8401 kinase inhibitor protein YP_688294.1 786238 R 373384 CDS YP_688295.1 110804776 4207330 complement(786773..788173) 1 NC_008258.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 788173 bioA 4207330 bioA Shigella flexneri 5 str. 8401 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_688295.1 786773 R 373384 CDS YP_688296.1 110804775 4207329 788149..789189 1 NC_008258.1 Code: H; COG: COG0502; biotin synthesis sulfur insertion protein 789189 bioB 4207329 bioB Shigella flexneri 5 str. 8401 biotin synthesis sulfur insertion protein YP_688296.1 788149 D 373384 CDS YP_688297.1 110804777 4207331 789186..790340 1 NC_008258.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 790340 bioF 4207331 bioF Shigella flexneri 5 str. 8401 8-amino-7-oxononanoate synthase YP_688297.1 789186 D 373384 CDS YP_688298.1 110804778 4207332 790327..791082 1 NC_008258.1 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 791082 bioC 4207332 bioC Shigella flexneri 5 str. 8401 biotin biosynthesis protein BioC YP_688298.1 790327 D 373384 CDS YP_688299.1 110804779 4207333 791075..791752 1 NC_008258.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 791752 bioD 4207333 bioD Shigella flexneri 5 str. 8401 dithiobiotin synthetase YP_688299.1 791075 D 373384 CDS YP_688300.1 110804780 4207334 792331..794352 1 NC_008258.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 794352 uvrB 4207334 uvrB Shigella flexneri 5 str. 8401 excinuclease ABC subunit B YP_688300.1 792331 D 373384 CDS YP_688301.1 110804781 4207335 complement(794544..795452) 1 NC_008258.1 Code: S; COG: COG0391; structural protein 795452 ybhK 4207335 ybhK Shigella flexneri 5 str. 8401 structural protein YP_688301.1 794544 R 373384 CDS YP_688302.1 110804782 4207336 795817..796839 1 NC_008258.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 796839 moaA 4207336 moaA Shigella flexneri 5 str. 8401 molybdenum cofactor biosynthesis protein A YP_688302.1 795817 D 373384 CDS YP_688303.1 110804783 4207337 796861..797373 1 NC_008258.1 Code: H; COG: COG0521; molybdopterin biosynthesis protein B 797373 moaB 4207337 moaB Shigella flexneri 5 str. 8401 molybdopterin biosynthesis protein B YP_688303.1 796861 D 373384 CDS YP_688304.1 110804784 4207338 797376..797861 1 NC_008258.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 797861 moaC 4207338 moaC Shigella flexneri 5 str. 8401 molybdenum cofactor biosynthesis protein MoaC YP_688304.1 797376 D 373384 CDS YP_688305.1 110804785 4207339 797854..798099 1 NC_008258.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 798099 moaD 4207339 moaD Shigella flexneri 5 str. 8401 molybdopterin synthase small subunit YP_688305.1 797854 D 373384 CDS YP_688306.1 110804786 4207340 798101..798553 1 NC_008258.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 798553 moaE 4207340 moaE Shigella flexneri 5 str. 8401 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_688306.1 798101 D 373384 CDS YP_688307.1 110804787 4207341 798690..799394 1 NC_008258.1 Code: R; COG: COG0670; hypothetical protein 799394 ybhL 4207341 ybhL Shigella flexneri 5 str. 8401 hypothetical protein YP_688307.1 798690 D 373384 CDS YP_688308.1 110804788 4210616 799599..800312 1 NC_008258.1 Code: R; COG: COG0670; hypothetical protein 800312 ybhM 4210616 ybhM Shigella flexneri 5 str. 8401 hypothetical protein YP_688308.1 799599 D 373384 CDS YP_688309.1 110804789 4210617 complement(800348..801304) 1 NC_008258.1 Code: S; COG: COG0392; hypothetical protein 801304 ybhN 4210617 ybhN Shigella flexneri 5 str. 8401 hypothetical protein YP_688309.1 800348 R 373384 CDS YP_688310.1 110804790 4210618 complement(801304..802545) 1 NC_008258.1 Code: I; COG: COG1502; cardiolipin synthase 2 802545 ybhO 4210618 ybhO Shigella flexneri 5 str. 8401 cardiolipin synthase 2 YP_688310.1 801304 R 373384 CDS YP_688311.1 110804791 4210619 complement(802542..803303) 1 NC_008258.1 Code: R; COG: COG3568; hypothetical protein 803303 ybhP 4210619 ybhP Shigella flexneri 5 str. 8401 hypothetical protein YP_688311.1 802542 R 373384 CDS YP_688312.1 110804792 4210620 803436..803846 1 NC_008258.1 hypothetical protein 803846 ybhQ 4210620 ybhQ Shigella flexneri 5 str. 8401 hypothetical protein YP_688312.1 803436 D 373384 CDS YP_688313.1 110804793 4210622 complement(804926..806059) 1 NC_008258.1 Code: V; COG: COG0842; hypothetical protein 806059 ybhS 4210622 ybhS Shigella flexneri 5 str. 8401 hypothetical protein YP_688313.1 804926 R 373384 CDS YP_688314.1 110804794 4210623 complement(806052..807788) 1 NC_008258.1 Code: V; COG: COG1131; ABC transporter ATP-binding protein 807788 ybhF 4210623 ybhF Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_688314.1 806052 R 373384 CDS YP_688315.1 110804795 4210624 complement(807781..808776) 1 NC_008258.1 Code: M; COG: COG0845; hypothetical protein 808776 4210624 SFV_0778 Shigella flexneri 5 str. 8401 hypothetical protein YP_688315.1 807781 R 373384 CDS YP_688316.1 110804796 4210625 complement(808779..809450) 1 NC_008258.1 Code: K; COG: COG1309; DNA-binding transcriptional regulator 809450 ybiH 4210625 ybiH Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_688316.1 808779 R 373384 CDS YP_688317.1 110804797 4210626 809679..810899 1 NC_008258.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 810899 rhlE 4210626 rhlE Shigella flexneri 5 str. 8401 ATP-dependent RNA helicase RhlE YP_688317.1 809679 D 373384 CDS YP_688318.1 110804799 4210628 complement(811073..811555) 1 NC_008258.1 Code: S; COG: COG3236; hypothetical protein 811555 ybiA 4210628 ybiA Shigella flexneri 5 str. 8401 hypothetical protein YP_688318.1 811073 R 373384 CDS YP_688319.1 110804798 4210627 811540..813825 1 NC_008258.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 813825 dinG 4210627 dinG Shigella flexneri 5 str. 8401 ATP-dependent DNA helicase DinG YP_688319.1 811540 D 373384 CDS YP_688320.1 110804800 4210629 813853..814815 1 NC_008258.1 Code: E; COG: COG0547; glycosyl transferase 814815 ybiB 4210629 ybiB Shigella flexneri 5 str. 8401 glycosyl transferase YP_688320.1 813853 D 373384 CDS YP_688321.1 110804801 4210630 814956..816041 1 NC_008258.1 Code: C; COG: COG2055; hypothetical protein 816041 ybiC 4210630 ybiC Shigella flexneri 5 str. 8401 hypothetical protein YP_688321.1 814956 D 373384 CDS YP_688322.1 110804802 4210631 complement(816270..816530) 1 NC_008258.1 hypothetical protein 816530 ybiJ 4210631 ybiJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688322.1 816270 R 373384 CDS YP_688323.1 110804803 4210632 complement(816795..817061) 1 NC_008258.1 Code: T; COG: COG1734; hypothetical protein 817061 ybiI 4210632 ybiI Shigella flexneri 5 str. 8401 hypothetical protein YP_688323.1 816795 R 373384 CDS YP_688324.1 110804804 4210633 complement(817135..817812) 1 NC_008258.1 Code: S; COG: COG3128; hydroxylase 817812 ybiX 4210633 ybiX Shigella flexneri 5 str. 8401 hydroxylase YP_688324.1 817135 R 373384 CDS YP_688325.1 110804805 4210634 819910..821256 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 821256 4210634 SFV_0788 Shigella flexneri 5 str. 8401 IS4 orf YP_688325.1 819910 D 373384 CDS YP_688326.1 110804806 4209424 complement(821839..822243) 1 NC_008258.1 hypothetical protein 822243 ybiM 4209424 ybiM Shigella flexneri 5 str. 8401 hypothetical protein YP_688326.1 821839 R 373384 CDS YP_688327.1 110804807 4209425 822294..823301 1 NC_008258.1 Code: R; COG: COG3129; SAM-dependent methyltransferase 823301 ybiN 4209425 ybiN Shigella flexneri 5 str. 8401 SAM-dependent methyltransferase YP_688327.1 822294 D 373384 CDS YP_688328.1 110804808 4209426 complement(823298..825241) 1 NC_008258.1 transport protein 825241 ybiO 4209426 ybiO Shigella flexneri 5 str. 8401 transport protein YP_688328.1 823298 R 373384 CDS YP_688329.1 110804809 4209427 complement(825783..826505) 1 NC_008258.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 826505 glnQ 4209427 glnQ Shigella flexneri 5 str. 8401 glutamine ABC transporter ATP-binding protein YP_688329.1 825783 R 373384 CDS YP_688330.1 110804810 4209428 complement(826502..827161) 1 NC_008258.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 827161 glnP 4209428 glnP Shigella flexneri 5 str. 8401 glutamine ABC transporter permease YP_688330.1 826502 R 373384 CDS YP_688331.1 110804811 4209429 complement(827300..828046) 1 NC_008258.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter substrate-binding protein 828046 glnH 4209429 glnH Shigella flexneri 5 str. 8401 glutamine ABC transporter substrate-binding protein YP_688331.1 827300 R 373384 CDS YP_688332.1 110804812 4209430 complement(828450..829076) 1 NC_008258.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 829076 dps 4209430 dps Shigella flexneri 5 str. 8401 DNA starvation/stationary phase protection protein Dps YP_688332.1 828450 R 373384 CDS YP_688333.1 110804813 4209431 complement(829252..830139) 1 NC_008258.1 Code: R; COG: COG5006; threonine and homoserine efflux system 830139 ybiF 4209431 ybiF Shigella flexneri 5 str. 8401 threonine and homoserine efflux system YP_688333.1 829252 R 373384 CDS YP_688334.1 110804814 4209432 830492..831007 1 NC_008258.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 831007 ompX 4209432 ompX Shigella flexneri 5 str. 8401 outer membrane protein X YP_688334.1 830492 D 373384 CDS YP_688335.1 110804815 4209433 complement(831055..832638) 1 NC_008258.1 Code: R; COG: COG2194; hypothetical protein 832638 ybiP 4209433 ybiP Shigella flexneri 5 str. 8401 hypothetical protein YP_688335.1 831055 R 373384 CDS YP_688336.1 110804816 4209434 833224..833691 1 NC_008258.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 833691 4209434 SFV_0800 Shigella flexneri 5 str. 8401 manganese transport regulator MntR YP_688336.1 833224 D 373384 CDS YP_688337.1 110804817 4209435 833688..834806 1 NC_008258.1 Code: P; COG: COG0471; hypothetical protein 834806 ybiR 4209435 ybiR Shigella flexneri 5 str. 8401 hypothetical protein YP_688337.1 833688 D 373384 CDS YP_688338.1 110804818 4209436 complement(834864..835784) 1 NC_008258.1 Code: S; COG: COG1376; hypothetical protein 835784 ybiS 4209436 ybiS Shigella flexneri 5 str. 8401 hypothetical protein YP_688338.1 834864 R 373384 CDS YP_688339.1 110804819 4209437 836003..837595 1 NC_008258.1 Code: R; COG: COG0488; ABC transporter ATP-binding protein 837595 ybiT 4209437 ybiT Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_688339.1 836003 D 373384 CDS YP_688340.1 110804820 4209438 complement(837836..839101) 1 NC_008258.1 hypothetical protein 839101 ybiU 4209438 ybiU Shigella flexneri 5 str. 8401 hypothetical protein YP_688340.1 837836 R 373384 CDS YP_688341.1 110804821 4209439 complement(839253..840068) 1 NC_008258.1 Code: R; COG: COG0561; hypothetical protein 840068 4209439 SFV_0805 Shigella flexneri 5 str. 8401 hypothetical protein YP_688341.1 839253 R 373384 CDS YP_688342.1 110804822 4209440 complement(840214..842646) 1 NC_008258.1 Code: C; COG: COG1882; formate acetyltransferase 842646 ybiW 4209440 ybiW Shigella flexneri 5 str. 8401 formate acetyltransferase YP_688342.1 840214 R 373384 CDS YP_688343.1 110804823 4209441 complement(842652..843551) 1 NC_008258.1 Code: O; COG: COG1180; pyruvate formate-lyase 2 activating enzyme 843551 ybiY 4209441 ybiY Shigella flexneri 5 str. 8401 pyruvate formate-lyase 2 activating enzyme YP_688343.1 842652 R 373384 CDS YP_688344.2 162139353 4209442 843682..844344 1 NC_008258.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 844344 mipB 4209442 mipB Shigella flexneri 5 str. 8401 fructose-6-phosphate aldolase YP_688344.2 843682 D 373384 CDS YP_688345.1 110804825 4208855 complement(844523..845248) 1 NC_008258.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 845248 moeB 4208855 moeB Shigella flexneri 5 str. 8401 molybdopterin biosynthesis protein MoeB YP_688345.1 844523 R 373384 CDS YP_688346.1 110804826 4208856 complement(845272..846507) 1 NC_008258.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 846507 moeA 4208856 moeA Shigella flexneri 5 str. 8401 molybdopterin biosynthesis protein MoeA YP_688346.1 845272 R 373384 CDS YP_688347.1 110804827 4208857 846769..847677 1 NC_008258.1 Code: E; COG: COG1446; L-asparaginase 847677 ybiK 4208857 ybiK Shigella flexneri 5 str. 8401 L-asparaginase YP_688347.1 846769 D 373384 CDS YP_688348.1 110804828 4208858 847697..849535 1 NC_008258.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 849535 4208858 SFV_0812 Shigella flexneri 5 str. 8401 glutathione transporter ATP-binding protein YP_688348.1 847697 D 373384 CDS YP_688349.1 110804829 4208859 849555..851099 1 NC_008258.1 Code: E; COG: COG0747; transport protein 851099 4208859 SFV_0813 Shigella flexneri 5 str. 8401 transport protein YP_688349.1 849555 D 373384 CDS YP_688350.1 110804830 4208860 851117..852037 1 NC_008258.1 Code: EP; COG: COG0601; transport system permease 852037 4208860 SFV_0814 Shigella flexneri 5 str. 8401 transport system permease YP_688350.1 851117 D 373384 CDS YP_688351.1 110804831 4208862 853053..855479 1 NC_008258.1 hypothetical protein 855479 4208862 SFV_0816 Shigella flexneri 5 str. 8401 hypothetical protein YP_688351.1 853053 D 373384 CDS YP_688352.1 110804832 4208863 855487..856815 1 NC_008258.1 hypothetical protein 856815 4208863 SFV_0817 Shigella flexneri 5 str. 8401 hypothetical protein YP_688352.1 855487 D 373384 CDS YP_688353.1 110804833 4208864 complement(856862..858187) 1 NC_008258.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 858187 rimO 4208864 rimO Shigella flexneri 5 str. 8401 ribosomal protein S12 methylthiotransferase YP_688353.1 856862 R 373384 CDS YP_688354.1 110804834 4208865 858400..858783 1 NC_008258.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 858783 bssR 4208865 bssR Shigella flexneri 5 str. 8401 biofilm formation regulatory protein BssR YP_688354.1 858400 D 373384 CDS YP_688355.1 110804835 4208867 complement(860005..860583) 1 NC_008258.1 Code: O; COG: COG0625; transferase 860583 yliJ 4208867 yliJ Shigella flexneri 5 str. 8401 transferase YP_688355.1 860005 R 373384 CDS YP_688356.1 110804836 4208869 861899..862201 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 862201 4208869 SFV_0823 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688356.1 861899 D 373384 CDS YP_688357.1 110804837 4208870 862342..863055 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 863055 4208870 SFV_0824 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688357.1 862342 D 373384 CDS YP_688358.1 110804838 4208871 complement(863392..864150) 1 NC_008258.1 Code: KG; COG: COG1349; DNA-binding transcriptional repressor DeoR 864150 deoR 4208871 deoR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor DeoR YP_688358.1 863392 R 373384 CDS YP_688359.1 110804839 4208872 complement(864208..864819) 1 NC_008258.1 Code: I; COG: COG0671; undecaprenyl pyrophosphate phosphatase 864819 ybjG 4208872 ybjG Shigella flexneri 5 str. 8401 undecaprenyl pyrophosphate phosphatase YP_688359.1 864208 R 373384 CDS YP_688360.1 110804840 4208873 865089..866315 1 NC_008258.1 Code: GEPR; COG: COG0477; chloramphenicol resistance pump Cmr 866315 cmr 4208873 cmr Shigella flexneri 5 str. 8401 chloramphenicol resistance pump Cmr YP_688360.1 865089 D 373384 CDS YP_688361.1 110804841 4208874 complement(866356..866634) 1 NC_008258.1 hypothetical protein 866634 ybjH 4208874 ybjH Shigella flexneri 5 str. 8401 hypothetical protein YP_688361.1 866356 R 373384 CDS YP_688362.1 110804842 4207780 complement(866726..867541) 1 NC_008258.1 Code: R; COG: COG0561; hypothetical protein 867541 4207780 SFV_0829 Shigella flexneri 5 str. 8401 hypothetical protein YP_688362.1 866726 R 373384 CDS YP_688363.1 110804843 4207781 complement(867541..868695) 1 NC_008258.1 Code: GEPR; COG: COG0477; DeoR-type transcriptional regulator 868695 4207781 SFV_0830 Shigella flexneri 5 str. 8401 DeoR-type transcriptional regulator YP_688363.1 867541 R 373384 CDS YP_688364.1 110804844 4207782 868833..869369 1 NC_008258.1 Code: S; COG: COG3226; DeoR-type transcriptional regulator 869369 4207782 SFV_0831 Shigella flexneri 5 str. 8401 DeoR-type transcriptional regulator YP_688364.1 868833 D 373384 CDS YP_688365.1 110804845 4207783 complement(869544..871229) 1 NC_008258.1 Code: R; COG: COG2985; hypothetical protein 871229 4207783 SFV_0832 Shigella flexneri 5 str. 8401 hypothetical protein YP_688365.1 869544 R 373384 CDS YP_688366.1 110804846 4207784 871499..871876 1 NC_008258.1 hypothetical protein 871876 ybjM 4207784 ybjM Shigella flexneri 5 str. 8401 hypothetical protein YP_688366.1 871499 D 373384 CDS YP_688367.1 110804847 4207785 complement(871906..872163) 1 NC_008258.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 1 872163 grxA 4207785 grxA Shigella flexneri 5 str. 8401 glutaredoxin 1 YP_688367.1 871906 R 373384 CDS YP_688368.1 110804848 4207786 872323..872610 1 NC_008258.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 872610 ybjC 4207786 ybjC Shigella flexneri 5 str. 8401 hypothetical protein YP_688368.1 872323 D 373384 CDS YP_688369.1 110804849 4207787 872594..873316 1 NC_008258.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 873316 mdaA 4207787 mdaA Shigella flexneri 5 str. 8401 nitroreductase A YP_688369.1 872594 D 373384 CDS YP_688370.1 110804850 4207788 873377..874279 1 NC_008258.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 874279 rimK 4207788 rimK Shigella flexneri 5 str. 8401 ribosomal protein S6 modification protein YP_688370.1 873377 D 373384 CDS YP_688371.1 110804851 4207789 874355..874843 1 NC_008258.1 sensory transduction regulator 874843 ybjN 4207789 ybjN Shigella flexneri 5 str. 8401 sensory transduction regulator YP_688371.1 874355 D 373384 CDS YP_688372.1 110804852 4207790 875120..876307 1 NC_008258.1 Code: E; COG: COG0687; spermidine/putrescine ABC transporter substrate-binding protein 876307 potF 4207790 potF Shigella flexneri 5 str. 8401 spermidine/putrescine ABC transporter substrate-binding protein YP_688372.1 875120 D 373384 CDS YP_688373.1 110804853 4207792 877545..878498 1 NC_008258.1 Code: E; COG: COG1176; putrescine ABC transporter membrane protein 878498 potH 4207792 potH Shigella flexneri 5 str. 8401 putrescine ABC transporter membrane protein YP_688373.1 877545 D 373384 CDS YP_688374.1 110804854 4207793 878495..879340 1 NC_008258.1 Code: E; COG: COG1177; putrescine ABC transporter membrane protein 879340 potI 4207793 potI Shigella flexneri 5 str. 8401 putrescine ABC transporter membrane protein YP_688374.1 878495 D 373384 CDS YP_688375.1 110804855 4207794 879400..879888 1 NC_008258.1 hypothetical protein 879888 ybjO 4207794 ybjO Shigella flexneri 5 str. 8401 hypothetical protein YP_688375.1 879400 D 373384 CDS YP_688376.1 110804856 4207795 879929..881056 1 NC_008258.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 881056 rumB 4207795 rumB Shigella flexneri 5 str. 8401 23S rRNA methyluridine methyltransferase YP_688376.1 879929 D 373384 CDS YP_688377.1 110804857 4207796 complement(881231..881962) 1 NC_008258.1 Code: ET; COG: COG0834; arginine ABC transporter substrate-binding protein 881962 artJ 4207796 artJ Shigella flexneri 5 str. 8401 arginine ABC transporter substrate-binding protein YP_688377.1 881231 R 373384 CDS YP_688378.1 110804858 4207797 complement(882254..882922) 1 NC_008258.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 882922 artM 4207797 artM Shigella flexneri 5 str. 8401 arginine transporter permease subunit ArtM YP_688378.1 882254 R 373384 CDS YP_688379.1 110804859 4207798 complement(882922..883638) 1 NC_008258.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 883638 artQ 4207798 artQ Shigella flexneri 5 str. 8401 arginine transporter permease subunit ArtQ YP_688379.1 882922 R 373384 CDS YP_688380.1 110804860 4208576 complement(883645..884376) 1 NC_008258.1 Code: ET; COG: COG0834; arginine ABC transporter substrate-binding protein 884376 artI 4208576 artI Shigella flexneri 5 str. 8401 arginine ABC transporter substrate-binding protein YP_688380.1 883645 R 373384 CDS YP_688381.1 110804861 4208577 complement(884394..885122) 1 NC_008258.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 885122 artP 4208577 artP Shigella flexneri 5 str. 8401 arginine transporter ATP-binding subunit YP_688381.1 884394 R 373384 CDS YP_688382.1 110804862 4208578 complement(885340..885855) 1 NC_008258.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein 885855 ybjP 4208578 ybjP Shigella flexneri 5 str. 8401 lipoprotein YP_688382.1 885340 R 373384 CDS YP_688383.1 110804863 4208579 886504..887715 1 NC_008258.1 hypothetical protein 887715 4208579 SFV_0851 Shigella flexneri 5 str. 8401 hypothetical protein YP_688383.1 886504 D 373384 CDS YP_688384.1 110804864 4208580 complement(887726..888229) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 888229 insB 4208580 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688384.1 887726 R 373384 CDS YP_688385.1 110804865 4208581 888343..889050 1 NC_008258.1 hypothetical protein 889050 4208581 SFV_0853 Shigella flexneri 5 str. 8401 hypothetical protein YP_688385.1 888343 D 373384 CDS YP_688386.1 110804866 4208582 889261..889584 1 NC_008258.1 Code: S; COG: COG0393; hypothetical protein 889584 4208582 SFV_0854 Shigella flexneri 5 str. 8401 hypothetical protein YP_688386.1 889261 D 373384 CDS YP_688387.1 110804867 4208583 889581..890411 1 NC_008258.1 Code: V; COG: COG3023; regulator 890411 4208583 SFV_0855 Shigella flexneri 5 str. 8401 regulator YP_688387.1 889581 D 373384 CDS YP_688388.1 110804868 4208584 complement(890408..891457) 1 NC_008258.1 Code: MG; COG: COG0451; nucleotide di-P-sugar epimerase or dehydratase 891457 4208584 SFV_0856 Shigella flexneri 5 str. 8401 nucleotide di-P-sugar epimerase or dehydratase YP_688388.1 890408 R 373384 CDS YP_688389.1 110804869 4208585 complement(891520..892950) 1 NC_008258.1 Code: MG; COG: COG0702; dTDP-glucose enzyme 892950 ybjT 4208585 ybjT Shigella flexneri 5 str. 8401 dTDP-glucose enzyme YP_688389.1 891520 R 373384 CDS YP_688390.1 110804870 4208586 complement(892961..893962) 1 NC_008258.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 893962 ybjU 4208586 ybjU Shigella flexneri 5 str. 8401 L-threonine aldolase YP_688390.1 892961 R 373384 CDS YP_688391.1 110804871 4208587 complement(893999..895717) 1 NC_008258.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 895717 poxB 4208587 poxB Shigella flexneri 5 str. 8401 pyruvate dehydrogenase YP_688391.1 893999 R 373384 CDS YP_688392.1 110804872 4208588 complement(895850..896818) 1 NC_008258.1 Code: C; COG: COG1018; HCP oxidoreductase, NADH-dependent 896818 4208588 SFV_0860 Shigella flexneri 5 str. 8401 HCP oxidoreductase, NADH-dependent YP_688392.1 895850 R 373384 CDS YP_688393.1 110804873 4208589 complement(896830..898482) 1 NC_008258.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 898482 ybjW 4208589 ybjW Shigella flexneri 5 str. 8401 hydroxylamine reductase YP_688393.1 896830 R 373384 CDS YP_688394.1 110804874 4208590 complement(898626..899573) 1 NC_008258.1 Code: S; COG: COG2431; surface protein 899573 ybjE 4208590 ybjE Shigella flexneri 5 str. 8401 surface protein YP_688394.1 898626 R 373384 CDS YP_688395.1 110804875 4208591 complement(899982..900677) 1 NC_008258.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 900677 aqpZ 4208591 aqpZ Shigella flexneri 5 str. 8401 aquaporin Z YP_688395.1 899982 R 373384 CDS YP_688396.1 110804876 4208592 complement(900729..901232) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 901232 insB 4208592 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688396.1 900729 R 373384 CDS YP_688397.1 110804877 4208593 901307..901549 1 NC_008258.1 IS1 encoded protein 901549 4208593 SFV_0865 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688397.1 901307 D 373384 CDS YP_688398.1 110804878 4208594 901878..903536 1 NC_008258.1 Code: L; COG: COG3593; hypothetical protein 903536 ybjD 4208594 ybjD Shigella flexneri 5 str. 8401 hypothetical protein YP_688398.1 901878 D 373384 CDS YP_688399.1 110804879 4208595 complement(903533..904525) 1 NC_008258.1 Code: S; COG: COG2990; hypothetical protein 904525 ybjX 4208595 ybjX Shigella flexneri 5 str. 8401 hypothetical protein YP_688399.1 903533 R 373384 CDS YP_688400.1 110804880 4208934 904594..904728 1 NC_008258.1 hypothetical protein 904728 4208934 SFV_0868 Shigella flexneri 5 str. 8401 hypothetical protein YP_688400.1 904594 D 373384 CDS YP_688401.1 110804881 4208935 904613..905755 1 NC_008258.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 905755 4208935 SFV_0869 Shigella flexneri 5 str. 8401 macrolide transporter subunit MacA YP_688401.1 904613 D 373384 CDS YP_688402.1 110804882 4208937 complement(907772..908026) 1 NC_008258.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 908026 cspD 4208937 cspD Shigella flexneri 5 str. 8401 stationary phase/starvation inducible regulatory protein CspD YP_688402.1 907772 R 373384 CDS YP_688403.1 110804883 4208938 908319..908639 1 NC_008258.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 908639 clpS 4208938 clpS Shigella flexneri 5 str. 8401 ATP-dependent Clp protease adaptor protein ClpS YP_688403.1 908319 D 373384 CDS YP_688404.1 110804884 4208939 908670..910946 1 NC_008258.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 910946 clpA 4208939 clpA Shigella flexneri 5 str. 8401 ATP-dependent Clp protease ATP-binding subunit YP_688404.1 908670 D 373384 CDS YP_688405.1 110804885 4208941 complement(911690..911908) 1 NC_008258.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 911908 infA 4208941 infA Shigella flexneri 5 str. 8401 translation initiation factor IF-1 YP_688405.1 911690 R 373384 CDS YP_688406.1 110804886 4208942 complement(912193..912897) 1 NC_008258.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 912897 aat 4208942 aat Shigella flexneri 5 str. 8401 leucyl/phenylalanyl-tRNA--protein transferase YP_688406.1 912193 R 373384 CDS YP_688407.1 110804887 4208943 complement(912939..914660) 1 NC_008258.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 914660 cydC 4208943 cydC Shigella flexneri 5 str. 8401 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_688407.1 912939 R 373384 CDS YP_688408.1 110804888 4208944 complement(914661..916427) 1 NC_008258.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 916427 cydD 4208944 cydD Shigella flexneri 5 str. 8401 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_688408.1 914661 R 373384 CDS YP_688409.1 110804889 4208945 complement(916550..917515) 1 NC_008258.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 917515 trxB 4208945 trxB Shigella flexneri 5 str. 8401 thioredoxin reductase YP_688409.1 916550 R 373384 CDS YP_688410.1 110804890 4208946 918059..918553 1 NC_008258.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 918553 lrp 4208946 lrp Shigella flexneri 5 str. 8401 leucine-responsive transcriptional regulator YP_688410.1 918059 D 373384 CDS YP_688411.1 110804891 4208947 918688..922794 1 NC_008258.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 922794 ftsK 4208947 ftsK Shigella flexneri 5 str. 8401 DNA translocase FtsK YP_688411.1 918688 D 373384 CDS YP_688412.1 110804892 4208948 922949..923560 1 NC_008258.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 923560 lolA 4208948 lolA Shigella flexneri 5 str. 8401 outer-membrane lipoprotein carrier protein YP_688412.1 922949 D 373384 CDS YP_688413.1 110804893 4208949 923571..924914 1 NC_008258.1 Code: L; COG: COG2256; recombination factor protein RarA 924914 ycaJ 4208949 ycaJ Shigella flexneri 5 str. 8401 recombination factor protein RarA YP_688413.1 923571 D 373384 CDS YP_688414.1 110804894 4208950 925005..926297 1 NC_008258.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 926297 serS 4208950 serS Shigella flexneri 5 str. 8401 seryl-tRNA synthetase YP_688414.1 925005 D 373384 CDS YP_688415.1 110804895 4207624 928992..929609 1 NC_008258.1 Code: C; COG: COG0437; anaerobic dimethyl sulfoxide reductase subunit B 929609 dmsB 4207624 dmsB Shigella flexneri 5 str. 8401 anaerobic dimethyl sulfoxide reductase subunit B YP_688415.1 928992 D 373384 CDS YP_688416.1 110804896 4207625 929611..930402 1 NC_008258.1 Code: R; COG: COG3302; anaerobic dimethyl sulfoxide reductase subunit C 930402 dmsC 4207625 dmsC Shigella flexneri 5 str. 8401 anaerobic dimethyl sulfoxide reductase subunit C YP_688416.1 929611 D 373384 CDS YP_688417.1 110804897 4207626 complement(930438..931064) 1 NC_008258.1 Code: Q; COG: COG1335; hypothetical protein 931064 ycaC 4207626 ycaC Shigella flexneri 5 str. 8401 hypothetical protein YP_688417.1 930438 R 373384 CDS YP_688418.1 110804898 4207627 931379..932527 1 NC_008258.1 Code: GEPR; COG: COG0477; MFS family transporter protein 932527 ycaD 4207627 ycaD Shigella flexneri 5 str. 8401 MFS family transporter protein YP_688418.1 931379 D 373384 CDS YP_688419.1 110804899 4207628 932840..933514 1 NC_008258.1 ISSfl4 ORF1 933514 4207628 SFV_0890 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_688419.1 932840 D 373384 CDS YP_688420.1 110804900 4207629 933511..933861 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 933861 4207629 SFV_0891 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_688420.1 933511 D 373384 CDS YP_688421.1 110804901 4207630 933858..934400 1 NC_008258.1 ISSfl4 ORF3 934400 4207630 SFV_0892 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_688421.1 933858 D 373384 CDS YP_688422.1 110804902 4207631 934406..934732 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 934732 4207631 SFV_0893 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_688422.1 934406 D 373384 CDS YP_688423.1 110804903 4207632 934863..935477 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 935477 4207632 SFV_0894 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_688423.1 934863 D 373384 CDS YP_688424.1 110804904 4207633 935493..935681 1 NC_008258.1 ISSfl4 ORF3 935681 4207633 SFV_0895 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_688424.1 935493 D 373384 CDS YP_688425.1 110804905 4207634 complement(936068..936334) 1 NC_008258.1 IS1 encoded protein 936334 4207634 SFV_0896 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688425.1 936068 R 373384 CDS YP_688426.1 110804906 4207635 936409..936912 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 936912 insB 4207635 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688426.1 936409 D 373384 CDS YP_688427.1 110804907 4207636 936914..937702 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 937702 ycaN 4207636 ycaN Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_688427.1 936914 D 373384 CDS YP_688428.1 110804908 4207638 938156..938458 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 938458 4207638 SFV_0900 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688428.1 938156 D 373384 CDS YP_688429.1 110804909 4207639 938599..939312 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 939312 4207639 SFV_0901 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688429.1 938599 D 373384 CDS YP_688430.1 110804910 4207640 complement(939695..940435) 1 NC_008258.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 940435 pflA 4207640 pflA Shigella flexneri 5 str. 8401 pyruvate formate lyase-activating enzyme 1 YP_688430.1 939695 R 373384 CDS YP_688431.1 110804911 4207641 complement(940627..942909) 1 NC_008258.1 Code: C; COG: COG1882; formate acetyltransferase 1 942909 pflB 4207641 pflB Shigella flexneri 5 str. 8401 formate acetyltransferase 1 YP_688431.1 940627 R 373384 CDS YP_688432.1 110804912 4207642 complement(942964..943995) 1 NC_008258.1 Code: P; COG: COG2116; formate transporter 943995 focA 4207642 focA Shigella flexneri 5 str. 8401 formate transporter YP_688432.1 942964 R 373384 CDS YP_688433.1 110804913 4207643 complement(944227..946020) 1 NC_008258.1 Code: S; COG: COG1944; hypothetical protein 946020 ycaO 4207643 ycaO Shigella flexneri 5 str. 8401 hypothetical protein YP_688433.1 944227 R 373384 CDS YP_688434.2 162139352 4208206 946942..948030 1 NC_008258.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 948030 serC 4208206 serC Shigella flexneri 5 str. 8401 phosphoserine aminotransferase YP_688434.2 946942 D 373384 CDS YP_688435.1 110804915 4208207 948101..949384 1 NC_008258.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 949384 aroA 4208207 aroA Shigella flexneri 5 str. 8401 3-phosphoshikimate 1-carboxyvinyltransferase YP_688435.1 948101 D 373384 CDS YP_688436.1 110804916 4208208 949510..950856 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 950856 4208208 SFV_0909 Shigella flexneri 5 str. 8401 IS4 orf YP_688436.1 949510 D 373384 CDS YP_688437.1 110804917 4208209 950968..951756 1 NC_008258.1 Code: O; COG: COG0501; heat shock protein 951756 ycaL 4208209 ycaL Shigella flexneri 5 str. 8401 heat shock protein YP_688437.1 950968 D 373384 CDS YP_688438.1 110804918 4208210 951929..952612 1 NC_008258.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 952612 cmk 4208210 cmk Shigella flexneri 5 str. 8401 cytidylate kinase YP_688438.1 951929 D 373384 CDS YP_688439.1 110804919 4208211 952723..954396 1 NC_008258.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 954396 rpsA 4208211 rpsA Shigella flexneri 5 str. 8401 30S ribosomal protein S1 YP_688439.1 952723 D 373384 CDS YP_688440.1 110804920 4208212 954556..954840 1 NC_008258.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 954840 ihfB 4208212 ihfB Shigella flexneri 5 str. 8401 integration host factor subunit beta YP_688440.1 954556 D 373384 CDS YP_688441.1 110804921 4208213 955438..956634 1 NC_008258.1 Code: R; COG: COG0658; hypothetical protein 956634 ycaI 4208213 ycaI Shigella flexneri 5 str. 8401 hypothetical protein YP_688441.1 955438 D 373384 CDS YP_688442.1 110804922 4208214 957344..959092 1 NC_008258.1 multicopy suppressor of htrB; involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 959092 msbA 4208214 msbA Shigella flexneri 5 str. 8401 lipid transporter ATP-binding/permease YP_688442.1 957344 D 373384 CDS YP_688443.1 110804923 4208215 959089..960075 1 NC_008258.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 960075 lpxK 4208215 lpxK Shigella flexneri 5 str. 8401 tetraacyldisaccharide 4'-kinase YP_688443.1 959089 D 373384 CDS YP_688444.1 110804924 4208216 960112..961344 1 NC_008258.1 Code: S; COG: COG3214; hypothetical protein 961344 ycaQ 4208216 ycaQ Shigella flexneri 5 str. 8401 hypothetical protein YP_688444.1 960112 D 373384 CDS YP_688445.1 110804925 4208217 961396..961578 1 NC_008258.1 Code: S; COG: COG2835; hypothetical protein 961578 ycaR 4208217 ycaR Shigella flexneri 5 str. 8401 hypothetical protein YP_688445.1 961396 D 373384 CDS YP_688446.1 110804926 4208218 961575..962321 1 NC_008258.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 962321 kdsB 4208218 kdsB Shigella flexneri 5 str. 8401 3-deoxy-manno-octulosonate cytidylyltransferase YP_688446.1 961575 D 373384 CDS YP_688447.1 110804927 4208219 962475..963368 1 NC_008258.1 hypothetical protein 963368 4208219 SFV_0920 Shigella flexneri 5 str. 8401 hypothetical protein YP_688447.1 962475 D 373384 CDS YP_688448.1 110804928 4208220 complement(963345..964124) 1 NC_008258.1 Code: S; COG: COG1434; hypothetical protein 964124 ycbC 4208220 ycbC Shigella flexneri 5 str. 8401 hypothetical protein YP_688448.1 963345 R 373384 CDS YP_688449.1 110804929 4208221 964260..965045 1 NC_008258.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 965045 smtA 4208221 smtA Shigella flexneri 5 str. 8401 metallothionein SmtA YP_688449.1 964260 D 373384 CDS YP_688450.1 110804930 4208222 965042..966364 1 NC_008258.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 966364 mukF 4208222 mukF Shigella flexneri 5 str. 8401 condesin subunit F YP_688450.1 965042 D 373384 CDS YP_688451.1 110804931 4208223 966318..967049 1 NC_008258.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 967049 mukE 4208223 mukE Shigella flexneri 5 str. 8401 condesin subunit E YP_688451.1 966318 D 373384 CDS YP_688452.1 110804932 4208556 967049..971509 1 NC_008258.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 971509 mukB 4208556 mukB Shigella flexneri 5 str. 8401 cell division protein MukB YP_688452.1 967049 D 373384 CDS YP_688453.1 110804933 4208557 971654..973000 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 973000 4208557 SFV_0926 Shigella flexneri 5 str. 8401 IS4 orf YP_688453.1 971654 D 373384 CDS YP_688454.1 110804934 4208558 973208..975055 1 NC_008258.1 Code: S; COG: COG2989; hypothetical protein 975055 ycbB 4208558 ycbB Shigella flexneri 5 str. 8401 hypothetical protein YP_688454.1 973208 D 373384 CDS YP_688455.1 110804935 4208559 975237..975785 1 NC_008258.1 Code: S; COG: COG3108; hypothetical protein 975785 ycbK 4208559 ycbK Shigella flexneri 5 str. 8401 hypothetical protein YP_688455.1 975237 D 373384 CDS YP_688456.1 110804936 4208560 975812..976459 1 NC_008258.1 Code: R; COG: COG0491; hypothetical protein 976459 ycbL 4208560 ycbL Shigella flexneri 5 str. 8401 hypothetical protein YP_688456.1 975812 D 373384 CDS YP_688457.1 110804937 4208561 complement(976682..977872) 1 NC_008258.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 977872 aspC 4208561 aspC Shigella flexneri 5 str. 8401 aromatic amino acid aminotransferase YP_688457.1 976682 R 373384 CDS YP_688458.1 110804938 4208562 complement(978057..979145) 1 NC_008258.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 979145 ompF 4208562 ompF Shigella flexneri 5 str. 8401 outer membrane protein F YP_688458.1 978057 R 373384 CDS YP_688459.1 110804939 4208563 complement(979746..981146) 1 NC_008258.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 981146 asnC 4208563 asnC Shigella flexneri 5 str. 8401 asparaginyl-tRNA synthetase YP_688459.1 979746 R 373384 CDS YP_688460.1 110804940 4208564 complement(981315..982565) 1 NC_008258.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 982565 pncB 4208564 pncB Shigella flexneri 5 str. 8401 nicotinate phosphoribosyltransferase YP_688460.1 981315 R 373384 CDS YP_688461.1 110804941 4208565 982783..985398 1 NC_008258.1 Code: E; COG: COG0308; aminopeptidase 985398 pepN 4208565 pepN Shigella flexneri 5 str. 8401 aminopeptidase YP_688461.1 982783 D 373384 CDS YP_688462.1 110804942 4208566 complement(985605..986372) 1 NC_008258.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonate ABC transporter ATP-binding protein 986372 ssuB 4208566 ssuB Shigella flexneri 5 str. 8401 aliphatic sulfonate ABC transporter ATP-binding protein YP_688462.1 985605 R 373384 CDS YP_688463.1 110804943 4208567 complement(986369..987022) 1 NC_008258.1 Code: P; COG: COG0600; transport system permease 987022 ycbM 4208567 ycbM Shigella flexneri 5 str. 8401 transport system permease YP_688463.1 986369 R 373384 CDS YP_688464.1 110804944 4208568 complement(986997..987836) 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 987836 4208568 SFV_0937 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_688464.1 986997 R 373384 CDS YP_688465.1 110804945 4208569 complement(987860..988225) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 988225 4208569 SFV_0938 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688465.1 987860 R 373384 CDS YP_688466.1 110804946 4208570 complement(988508..989653) 1 NC_008258.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 989653 ycbN 4208570 ycbN Shigella flexneri 5 str. 8401 alkanesulfonate monooxygenase YP_688466.1 988508 R 373384 CDS YP_688467.1 110804947 4208571 complement(989650..990651) 1 NC_008258.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 990651 ycbO 4208571 ycbO Shigella flexneri 5 str. 8401 alkanesulfonate transporter substrate-binding subunit YP_688467.1 989650 R 373384 CDS YP_688468.1 110804948 4208572 complement(990602..991177) 1 NC_008258.1 Code: R; COG: COG0431; NAD(P)H-dependent FMN reductase 991177 ycbP 4208572 ycbP Shigella flexneri 5 str. 8401 NAD(P)H-dependent FMN reductase YP_688468.1 990602 R 373384 CDS YP_688469.1 110804949 4208573 complement(991096..991416) 1 NC_008258.1 IS1 encoded protein 991416 4208573 SFV_0942 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688469.1 991096 R 373384 CDS YP_688470.1 110804950 4208574 991509..992012 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 992012 insB 4208574 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688470.1 991509 D 373384 CDS YP_688471.1 110804951 4208575 992301..992771 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 992771 4208575 SFV_0944 Shigella flexneri 5 str. 8401 fimbrial-like protein YP_688471.1 992301 D 373384 CDS YP_688472.1 110804952 4208746 complement(992765..993058) 1 NC_008258.1 IS1 ORF2 993058 insB 4208746 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688472.1 992765 R 373384 CDS YP_688473.1 110804953 4208747 complement(993095..993268) 1 NC_008258.1 IS1 ORF2 993268 insB 4208747 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688473.1 993095 R 373384 CDS YP_688474.1 110804954 4208748 993343..993543 1 NC_008258.1 IS1 encoded protein 993543 4208748 SFV_0947 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688474.1 993343 D 373384 CDS YP_688475.1 110804955 4208749 993712..994413 1 NC_008258.1 Code: NU; COG: COG3121; chaperone 994413 ycbR 4208749 ycbR Shigella flexneri 5 str. 8401 chaperone YP_688475.1 993712 D 373384 CDS YP_688476.1 110804956 4208750 994438..997038 1 NC_008258.1 Code: NU; COG: COG3188; outer membrane protein 997038 ycbS 4208750 ycbS Shigella flexneri 5 str. 8401 outer membrane protein YP_688476.1 994438 D 373384 CDS YP_688477.1 110804957 4208751 997092..998012 1 NC_008258.1 Code: NU; COG: COG3539; hypothetical protein 998012 4208751 SFV_0950 Shigella flexneri 5 str. 8401 hypothetical protein YP_688477.1 997092 D 373384 CDS YP_688478.1 110804958 4208752 998110..998652 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 998652 4208752 SFV_0951 Shigella flexneri 5 str. 8401 fimbrial-like protein YP_688478.1 998110 D 373384 CDS YP_688479.1 110804959 4208753 998660..999175 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 999175 4208753 SFV_0952 Shigella flexneri 5 str. 8401 fimbrial-like protein YP_688479.1 998660 D 373384 CDS YP_688480.1 110804960 4208754 999141..999878 1 NC_008258.1 Code: NU; COG: COG3121; putativi pili assembly chaperone 999878 ycbF 4208754 ycbF Shigella flexneri 5 str. 8401 putativi pili assembly chaperone YP_688480.1 999141 D 373384 CDS YP_688481.1 110804961 4208755 999989..1000999 1 NC_008258.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1000999 pyrD 4208755 pyrD Shigella flexneri 5 str. 8401 dihydroorotate dehydrogenase 2 YP_688481.1 999989 D 373384 CDS YP_688482.1 110804962 4208756 1001137..1001715 1 NC_008258.1 hypothetical protein 1001715 ycbW 4208756 ycbW Shigella flexneri 5 str. 8401 hypothetical protein YP_688482.1 1001137 D 373384 CDS YP_688483.1 110804963 4208757 complement(1001712..1002821) 1 NC_008258.1 Code: R; COG: COG3217; hypothetical protein 1002821 4208757 SFV_0956 Shigella flexneri 5 str. 8401 hypothetical protein YP_688483.1 1001712 R 373384 CDS YP_688484.1 110804964 4208758 1003065..1005173 1 NC_008258.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1005173 rlmL 4208758 rlmL Shigella flexneri 5 str. 8401 23S rRNA m(2)G2445 methyltransferase YP_688484.1 1003065 D 373384 CDS YP_688485.1 110804965 4208759 1005185..1007092 1 NC_008258.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase component 1007092 uup 4208759 uup Shigella flexneri 5 str. 8401 ABC transporter ATPase component YP_688485.1 1005185 D 373384 CDS YP_688486.1 110804966 4208760 1007222..1008475 1 NC_008258.1 Code: S; COG: COG2995; paraquat-inducible protein A 1008475 pqiA 4208760 pqiA Shigella flexneri 5 str. 8401 paraquat-inducible protein A YP_688486.1 1007222 D 373384 CDS YP_688487.1 110804967 4208761 1008480..1010120 1 NC_008258.1 Code: R; COG: COG3008; paraquat-inducible protein B 1010120 pqiB 4208761 pqiB Shigella flexneri 5 str. 8401 paraquat-inducible protein B YP_688487.1 1008480 D 373384 CDS YP_688488.1 110804968 4208762 1010117..1010680 1 NC_008258.1 Code: S; COG: COG3009; hypothetical protein 1010680 ymbA 4208762 ymbA Shigella flexneri 5 str. 8401 hypothetical protein YP_688488.1 1010117 D 373384 CDS YP_688489.2 162139351 4208763 complement(1011173..1011691) 1 NC_008258.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1011691 fabA 4208763 fabA Shigella flexneri 5 str. 8401 3-hydroxydecanoyl-ACP dehydratase YP_688489.2 1011173 R 373384 CDS YP_688490.1 110804970 4208764 complement(1011760..1013520) 1 NC_008258.1 Code: O; COG: COG1067; ATP-dependent protease 1013520 4208764 SFV_0963 Shigella flexneri 5 str. 8401 ATP-dependent protease YP_688490.1 1011760 R 373384 CDS YP_688491.1 110804971 4209233 1013705..1014157 1 NC_008258.1 Code: S; COG: COG3120; hypothetical protein 1014157 ycbG 4209233 ycbG Shigella flexneri 5 str. 8401 hypothetical protein YP_688491.1 1013705 D 373384 CDS YP_688492.1 110804972 4209234 complement(1014233..1015279) 1 NC_008258.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein OmpA 1015279 ompA 4209234 ompA Shigella flexneri 5 str. 8401 outer membrane protein OmpA YP_688492.1 1014233 R 373384 CDS YP_688493.1 110804973 4209235 complement(1015635..1016144) 1 NC_008258.1 Code: D; COG: COG5404; SOS cell division inhibitor 1016144 sulA 4209235 sulA Shigella flexneri 5 str. 8401 SOS cell division inhibitor YP_688493.1 1015635 R 373384 CDS YP_688494.1 110804974 4209237 1016864..1017229 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1017229 4209237 SFV_0968 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688494.1 1016864 D 373384 CDS YP_688495.1 110804975 4209238 1017253..1018092 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 1018092 4209238 SFV_0969 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_688495.1 1017253 D 373384 CDS YP_688496.1 110804976 4209239 complement(1018291..1020453) 1 NC_008258.1 Code: S; COG: COG1289; hypothetical protein 1020453 4209239 SFV_0970 Shigella flexneri 5 str. 8401 hypothetical protein YP_688496.1 1018291 R 373384 CDS YP_688497.1 110804977 4209240 complement(1020463..1020909) 1 NC_008258.1 Code: S; COG: COG3304; hypothetical protein 1020909 yccF 4209240 yccF Shigella flexneri 5 str. 8401 hypothetical protein YP_688497.1 1020463 R 373384 CDS YP_688498.1 110804978 4209241 1020963..1023086 1 NC_008258.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1023086 helD 4209241 helD Shigella flexneri 5 str. 8401 DNA helicase IV YP_688498.1 1020963 D 373384 CDS YP_688499.1 110804979 4209242 complement(1023118..1023585) 1 NC_008258.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1023585 mgsA 4209242 mgsA Shigella flexneri 5 str. 8401 methylglyoxal synthase YP_688499.1 1023118 R 373384 CDS YP_688500.1 110804980 4209243 complement(1023672..1024334) 1 NC_008258.1 Code: S; COG: COG3110; hypothetical protein 1024334 4209243 SFV_0974 Shigella flexneri 5 str. 8401 hypothetical protein YP_688500.1 1023672 R 373384 CDS YP_688501.1 110804981 4209244 1024426..1024920 1 NC_008258.1 Code: R; COG: COG1832; hypothetical protein 1024920 4209244 SFV_0975 Shigella flexneri 5 str. 8401 hypothetical protein YP_688501.1 1024426 D 373384 CDS YP_688502.1 110804982 4209245 complement(1024965..1025333) 1 NC_008258.1 Code: S; COG: COG3785; heat shock protein HspQ 1025333 yccV 4209245 yccV Shigella flexneri 5 str. 8401 heat shock protein HspQ YP_688502.1 1024965 R 373384 CDS YP_688503.1 110804983 4209246 complement(1025340..1026515) 1 NC_008258.1 Code: R; COG: COG1092; oxidoreductase 1026515 4209246 SFV_0977 Shigella flexneri 5 str. 8401 oxidoreductase YP_688503.1 1025340 R 373384 CDS YP_688504.1 110804984 4209247 complement(1026900..1027286) 1 NC_008258.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1027286 yccK 4209247 yccK Shigella flexneri 5 str. 8401 sulfur transfer protein TusE YP_688504.1 1026900 R 373384 CDS YP_688505.1 110804985 4209248 complement(1027320..1027979) 1 NC_008258.1 Code: R; COG: COG0670; hypothetical protein 1027979 yccA 4209248 yccA Shigella flexneri 5 str. 8401 hypothetical protein YP_688505.1 1027320 R 373384 CDS YP_688506.1 110804986 4209250 1028729..1029817 1 NC_008258.1 Code: C; COG: COG1740; hydrogenase-1 small subunit 1029817 hyaA 4209250 hyaA Shigella flexneri 5 str. 8401 hydrogenase-1 small subunit YP_688506.1 1028729 D 373384 CDS YP_688507.1 110804987 4209251 1029814..1031607 1 NC_008258.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1031607 hyaB 4209251 hyaB Shigella flexneri 5 str. 8401 hydrogenase 1 large subunit YP_688507.1 1029814 D 373384 CDS YP_688508.1 110804988 4209367 1031626..1032333 1 NC_008258.1 Code: C; COG: COG1969; hydrogenase 1 b-type cytochrome subunit 1032333 hyaC 4209367 hyaC Shigella flexneri 5 str. 8401 hydrogenase 1 b-type cytochrome subunit YP_688508.1 1031626 D 373384 CDS YP_688509.1 110804989 4209368 1032330..1032917 1 NC_008258.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1032917 hyaD 4209368 hyaD Shigella flexneri 5 str. 8401 hydrogenase 1 maturation protease YP_688509.1 1032330 D 373384 CDS YP_688510.1 110804990 4209369 1032914..1033312 1 NC_008258.1 involved in processing hydrogenases HyaA and HyaB; hydrogenase-1 operon protein HyaE 1033312 hyaE 4209369 hyaE Shigella flexneri 5 str. 8401 hydrogenase-1 operon protein HyaE YP_688510.1 1032914 D 373384 CDS YP_688511.1 110804991 4209370 1033309..1034166 1 NC_008258.1 nickel incorporation into hydrogenase-1 proteins 1034166 hyaF 4209370 hyaF Shigella flexneri 5 str. 8401 nickel incorporation into hydrogenase-1 proteins YP_688511.1 1033309 D 373384 CDS YP_688512.1 110804992 4209371 1034300..1035844 1 NC_008258.1 Code: C; COG: COG1271; third cytochrome oxidase subunit I 1035844 appC 4209371 appC Shigella flexneri 5 str. 8401 third cytochrome oxidase subunit I YP_688512.1 1034300 D 373384 CDS YP_688513.1 110804993 4209372 1035856..1036992 1 NC_008258.1 Code: C; COG: COG1294; third cytochrome oxidase subunit II 1036992 appB 4209372 appB Shigella flexneri 5 str. 8401 third cytochrome oxidase subunit II YP_688513.1 1035856 D 373384 CDS YP_688514.1 110804994 4209373 1037176..1038474 1 NC_008258.1 phosphoanhydride phosphorylase 1038474 appA 4209373 appA Shigella flexneri 5 str. 8401 phosphoanhydride phosphorylase YP_688514.1 1037176 D 373384 CDS YP_688515.1 110804995 4209374 complement(1038589..1040769) 1 NC_008258.1 Code: M; COG: COG3206; cryptic autophosphorylating protein tyrosine kinase Etk 1040769 yccC 4209374 yccC Shigella flexneri 5 str. 8401 cryptic autophosphorylating protein tyrosine kinase Etk YP_688515.1 1038589 R 373384 CDS YP_688516.1 110804996 4209375 complement(1040789..1041247) 1 NC_008258.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1041247 etp 4209375 etp Shigella flexneri 5 str. 8401 phosphotyrosine-protein phosphatase YP_688516.1 1040789 R 373384 CDS YP_688517.1 110804997 4209376 complement(1041223..1042383) 1 NC_008258.1 Code: M; COG: COG1596; function in exopolysaccharide production 1042383 yccZ 4209376 yccZ Shigella flexneri 5 str. 8401 function in exopolysaccharide production YP_688517.1 1041223 R 373384 CDS YP_688518.1 110804998 4209377 complement(1042408..1044504) 1 NC_008258.1 hypothetical protein 1044504 ymcA 4209377 ymcA Shigella flexneri 5 str. 8401 hypothetical protein YP_688518.1 1042408 R 373384 CDS YP_688519.1 110804999 4209378 complement(1044504..1045250) 1 NC_008258.1 hypothetical protein 1045250 ymcB 4209378 ymcB Shigella flexneri 5 str. 8401 hypothetical protein YP_688519.1 1044504 R 373384 CDS YP_688520.1 110805000 4209379 complement(1045247..1045891) 1 NC_008258.1 regulator 1045891 ymcC 4209379 ymcC Shigella flexneri 5 str. 8401 regulator YP_688520.1 1045247 R 373384 CDS YP_688521.1 110805001 4209380 complement(1045998..1046321) 1 NC_008258.1 hypothetical protein 1046321 ymcD 4209380 ymcD Shigella flexneri 5 str. 8401 hypothetical protein YP_688521.1 1045998 R 373384 CDS YP_688522.1 110805002 4209381 complement(1046745..1046957) 1 NC_008258.1 Code: K; COG: COG1278; cold shock-like protein 1046957 cspH 4209381 cspH Shigella flexneri 5 str. 8401 cold shock-like protein YP_688522.1 1046745 R 373384 CDS YP_688523.1 110805003 4209382 complement(1047198..1047431) 1 NC_008258.1 IS1 encoded protein 1047431 4209382 SFV_0998 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688523.1 1047198 R 373384 CDS YP_688524.1 110805004 4209383 1047506..1048009 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1048009 insB 4209383 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688524.1 1047506 D 373384 CDS YP_688525.1 110805005 4209384 1048031..1048231 1 NC_008258.1 Code: K; COG: COG1278; cold shock protein CspG 1048231 cspG 4209384 cspG Shigella flexneri 5 str. 8401 cold shock protein CspG YP_688525.1 1048031 D 373384 CDS YP_688526.1 110805006 4209385 1048625..1048798 1 NC_008258.1 GnsA protein 1048798 gnsA 4209385 gnsA Shigella flexneri 5 str. 8401 GnsA protein YP_688526.1 1048625 D 373384 CDS YP_688527.1 110805007 4208894 complement(1048847..1049920) 1 NC_008258.1 Code: C; COG: COG0348; hypothetical protein 1049920 yccM 4208894 yccM Shigella flexneri 5 str. 8401 hypothetical protein YP_688527.1 1048847 R 373384 CDS YP_688528.1 110805009 4208896 complement(1050022..1052472) 1 NC_008258.1 sensor protein torS 1052472 torS 4208896 torS Shigella flexneri 5 str. 8401 sensor protein torS YP_688528.1 1050022 R 373384 CDS YP_688529.1 110805008 4208895 1052471..1053499 1 NC_008258.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1053499 torT 4208895 torT Shigella flexneri 5 str. 8401 TMAO reductase system periplasmic protein TorT YP_688529.1 1052471 D 373384 CDS YP_688530.1 110805010 4208897 complement(1053472..1054164) 1 NC_008258.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1054164 torR 4208897 torR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator TorR YP_688530.1 1053472 R 373384 CDS YP_688531.1 110805011 4208898 1054251..1055423 1 NC_008258.1 Code: C; COG: COG3005; trimethylamine N-oxide reductase, cytochrome c-type subunit 1055423 torC 4208898 torC Shigella flexneri 5 str. 8401 trimethylamine N-oxide reductase, cytochrome c-type subunit YP_688531.1 1054251 D 373384 CDS YP_688532.1 110805012 4208899 1055423..1057969 1 NC_008258.1 Code: C; COG: COG0243; trimethylamine N-oxide reductase subunit 1057969 torA 4208899 torA Shigella flexneri 5 str. 8401 trimethylamine N-oxide reductase subunit YP_688532.1 1055423 D 373384 CDS YP_688533.1 110805013 4208901 complement(1058172..1058675) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1058675 insB 4208901 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688533.1 1058172 R 373384 CDS YP_688534.1 110805014 4208902 1058750..1058935 1 NC_008258.1 IS1 encoded protein 1058935 4208902 SFV_1010 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688534.1 1058750 D 373384 CDS YP_688535.1 110805015 4208903 complement(1059435..1059740) 1 NC_008258.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1059740 yccD 4208903 yccD Shigella flexneri 5 str. 8401 chaperone-modulator protein CbpM YP_688535.1 1059435 R 373384 CDS YP_688536.1 110805016 4208904 complement(1059740..1060660) 1 NC_008258.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1060660 cbpA 4208904 cbpA Shigella flexneri 5 str. 8401 curved DNA-binding protein CbpA YP_688536.1 1059740 R 373384 CDS YP_688537.1 110805017 4208905 1060921..1062177 1 NC_008258.1 hypothetical protein 1062177 yccE 4208905 yccE Shigella flexneri 5 str. 8401 hypothetical protein YP_688537.1 1060921 D 373384 CDS YP_688538.1 110805018 4208906 1062470..1063711 1 NC_008258.1 glucose-1-phosphatase/inositol phosphatase 1063711 agp 4208906 agp Shigella flexneri 5 str. 8401 glucose-1-phosphatase/inositol phosphatase YP_688538.1 1062470 D 373384 CDS YP_688539.1 110805019 4208907 complement(1063749..1063976) 1 NC_008258.1 hypothetical protein 1063976 yccJ 4208907 yccJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688539.1 1063749 R 373384 CDS YP_688540.1 110805020 4208908 complement(1063997..1064593) 1 NC_008258.1 stationary phase that binds TrpR repressor; TrpR binding protein WrbA 1064593 wrbA 4208908 wrbA Shigella flexneri 5 str. 8401 TrpR binding protein WrbA YP_688540.1 1063997 R 373384 CDS YP_688541.1 110805021 4208909 1064803..1065033 1 NC_008258.1 hypothetical protein 1065033 ycdF 4208909 ycdF Shigella flexneri 5 str. 8401 hypothetical protein YP_688541.1 1064803 D 373384 CDS YP_688542.1 110805022 4208910 complement(1065155..1066483) 1 NC_008258.1 Code: F; COG: COG2233; transport protein 1066483 ycdG 4208910 ycdG Shigella flexneri 5 str. 8401 transport protein YP_688542.1 1065155 R 373384 CDS YP_688543.1 110805023 4208911 complement(1066504..1066998) 1 NC_008258.1 Code: R; COG: COG1853; hypothetical protein 1066998 4208911 SFV_1019 Shigella flexneri 5 str. 8401 hypothetical protein YP_688543.1 1066504 R 373384 CDS YP_688544.1 110805024 4208912 complement(1067009..1067599) 1 NC_008258.1 Code: C; COG: COG0778; hypothetical protein 1067599 4208912 SFV_1020 Shigella flexneri 5 str. 8401 hypothetical protein YP_688544.1 1067009 R 373384 CDS YP_688545.1 110805025 4208913 complement(1067609..1068409) 1 NC_008258.1 Code: R; COG: COG0596; acetyltransferase 1068409 4208913 SFV_1021 Shigella flexneri 5 str. 8401 acetyltransferase YP_688545.1 1067609 R 373384 CDS YP_688546.1 110805026 4209007 complement(1068417..1068803) 1 NC_008258.1 Code: J; COG: COG0251; hypothetical protein 1068803 4209007 SFV_1022 Shigella flexneri 5 str. 8401 hypothetical protein YP_688546.1 1068417 R 373384 CDS YP_688547.1 110805027 4209008 complement(1068815..1069510) 1 NC_008258.1 Code: Q; COG: COG1335; synthetase 1069510 4209008 SFV_1023 Shigella flexneri 5 str. 8401 synthetase YP_688547.1 1068815 R 373384 CDS YP_688548.1 110805028 4209009 complement(1069507..1070601) 1 NC_008258.1 Code: C; COG: COG2141; hypothetical protein 1070601 4209009 SFV_1024 Shigella flexneri 5 str. 8401 hypothetical protein YP_688548.1 1069507 R 373384 CDS YP_688549.1 110805029 4209010 1070886..1071524 1 NC_008258.1 Code: K; COG: COG1309; tet operon regulator 1071524 ycdC 4209010 ycdC Shigella flexneri 5 str. 8401 tet operon regulator YP_688549.1 1070886 D 373384 CDS YP_688550.1 110805030 4209011 complement(1071818..1072891) 1 NC_008258.1 IS91 orf 1072891 4209011 SFV_1026 Shigella flexneri 5 str. 8401 IS91 orf YP_688550.1 1071818 R 373384 CDS YP_688551.1 110805031 4209012 complement(1073005..1073370) 1 NC_008258.1 IS91 ORF2 1073370 4209012 SFV_1027 Shigella flexneri 5 str. 8401 IS91 ORF2 YP_688551.1 1073005 R 373384 CDS YP_688552.1 110805032 4209013 1073540..1074133 1 NC_008258.1 Code: P; COG: COG0672; cytochrome 1074133 4209013 SFV_1028 Shigella flexneri 5 str. 8401 cytochrome YP_688552.1 1073540 D 373384 CDS YP_688553.1 110805033 4209014 1074191..1075318 1 NC_008258.1 Code: P; COG: COG2822; hypothetical protein 1075318 ycdO 4209014 ycdO Shigella flexneri 5 str. 8401 hypothetical protein YP_688553.1 1074191 D 373384 CDS YP_688554.1 110805034 4209015 1075324..1076589 1 NC_008258.1 Code: P; COG: COG2837; hypothetical protein 1076589 ycdB 4209015 ycdB Shigella flexneri 5 str. 8401 hypothetical protein YP_688554.1 1075324 D 373384 CDS YP_688555.1 110805035 4209017 complement(1078035..1078448) 1 NC_008258.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; PGA biosynthesis protein 1078448 pgaD 4209017 pgaD Shigella flexneri 5 str. 8401 PGA biosynthesis protein YP_688555.1 1078035 R 373384 CDS YP_688556.1 110805036 4209018 complement(1078450..1079775) 1 NC_008258.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 1079775 ycdQ 4209018 ycdQ Shigella flexneri 5 str. 8401 N-glycosyltransferase YP_688556.1 1078450 R 373384 CDS YP_688557.1 110805037 4209019 complement(1081027..1081530) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1081530 insB 4209019 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688557.1 1081027 R 373384 CDS YP_688558.1 110805038 4209022 1086594..1086932 1 NC_008258.1 hypothetical protein 1086932 4209022 SFV_1037 Shigella flexneri 5 str. 8401 hypothetical protein YP_688558.1 1086594 D 373384 CDS YP_688559.1 110805039 4209023 1087030..1088481 1 NC_008258.1 rtn-like protein 1088481 4209023 SFV_1038 Shigella flexneri 5 str. 8401 rtn-like protein YP_688559.1 1087030 D 373384 CDS YP_688560.1 110805040 4209024 complement(1088892..1089758) 1 NC_008258.1 Code: L; COG: COG2801; IS3 ORF2 1089758 4209024 SFV_1039 Shigella flexneri 5 str. 8401 IS3 ORF2 YP_688560.1 1088892 R 373384 CDS YP_688561.1 110805041 4209025 complement(1089755..1090054) 1 NC_008258.1 Code: L; COG: COG2963; IS3 ORF1 1090054 4209025 SFV_1040 Shigella flexneri 5 str. 8401 IS3 ORF1 YP_688561.1 1089755 R 373384 CDS YP_688562.1 110805042 4207265 1090157..1090537 1 NC_008258.1 hypothetical protein 1090537 4207265 SFV_1041 Shigella flexneri 5 str. 8401 hypothetical protein YP_688562.1 1090157 D 373384 CDS YP_688563.1 110805043 4207266 1090646..1091632 1 NC_008258.1 hypothetical protein 1091632 ycdU 4207266 ycdU Shigella flexneri 5 str. 8401 hypothetical protein YP_688563.1 1090646 D 373384 CDS YP_688564.1 110805044 4207269 1093140..1093877 1 NC_008258.1 Code: ER; COG: COG1387; hydrolase 1093877 ycdX 4207269 ycdX Shigella flexneri 5 str. 8401 hydrolase YP_688564.1 1093140 D 373384 CDS YP_688565.1 110805045 4207270 1093901..1094455 1 NC_008258.1 Code: R; COG: COG3381; oxidoreductase component 1094455 ycdY 4207270 ycdY Shigella flexneri 5 str. 8401 oxidoreductase component YP_688565.1 1093901 D 373384 CDS YP_688566.1 110805046 4207271 1094509..1095048 1 NC_008258.1 hypothetical protein 1095048 ycdZ 4207271 ycdZ Shigella flexneri 5 str. 8401 hypothetical protein YP_688566.1 1094509 D 373384 CDS YP_688567.1 110805047 4207273 complement(1095914..1096330) 1 NC_008258.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1096330 csgF 4207273 csgF Shigella flexneri 5 str. 8401 curli assembly protein CsgF YP_688567.1 1095914 R 373384 CDS YP_688568.1 110805048 4207274 complement(1096355..1096744) 1 NC_008258.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1096744 csgE 4207274 csgE Shigella flexneri 5 str. 8401 curli assembly protein CsgE YP_688568.1 1096355 R 373384 CDS YP_688569.1 110805049 4207275 complement(1096749..1097399) 1 NC_008258.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1097399 csgD 4207275 csgD Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator CsgD YP_688569.1 1096749 R 373384 CDS YP_688570.1 110805050 4207276 1098153..1098608 1 NC_008258.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1098608 csgB 4207276 csgB Shigella flexneri 5 str. 8401 curlin minor subunit YP_688570.1 1098153 D 373384 CDS YP_688571.1 110805051 4207278 1098822..1099124 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1099124 4207278 SFV_1054 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688571.1 1098822 D 373384 CDS YP_688572.1 110805052 4207279 1099265..1099903 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1099903 4207279 SFV_1055 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688572.1 1099265 D 373384 CDS YP_688573.1 110805053 4207280 1100761..1101072 1 NC_008258.1 hypothetical protein 1101072 4207280 SFV_1056 Shigella flexneri 5 str. 8401 hypothetical protein YP_688573.1 1100761 D 373384 CDS YP_688574.1 110805054 4207281 1101167..1101700 1 NC_008258.1 Code: R; COG: COG2110; hypothetical protein 1101700 4207281 SFV_1057 Shigella flexneri 5 str. 8401 hypothetical protein YP_688574.1 1101167 D 373384 CDS YP_688575.1 110805055 4207283 complement(1103127..1104284) 1 NC_008258.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1104284 mdoC 4207283 mdoC Shigella flexneri 5 str. 8401 glucans biosynthesis protein YP_688575.1 1103127 R 373384 CDS YP_688576.1 110805056 4209386 1104687..1106213 1 NC_008258.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1106213 mdoG 4209386 mdoG Shigella flexneri 5 str. 8401 glucan biosynthesis protein G YP_688576.1 1104687 D 373384 CDS YP_688577.1 110805057 4209387 1106206..1108749 1 NC_008258.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1108749 mdoH 4209387 mdoH Shigella flexneri 5 str. 8401 glucosyltransferase MdoH YP_688577.1 1106206 D 373384 CDS YP_688578.1 110805058 4209388 complement(1109165..1110238) 1 NC_008258.1 IS91 orf 1110238 4209388 SFV_1062 Shigella flexneri 5 str. 8401 IS91 orf YP_688578.1 1109165 R 373384 CDS YP_688579.1 110805059 4209389 complement(1110352..1110717) 1 NC_008258.1 IS91 ORF2 1110717 4209389 SFV_1063 Shigella flexneri 5 str. 8401 IS91 ORF2 YP_688579.1 1110352 R 373384 CDS YP_688580.1 110805060 4209390 1110742..1112376 1 NC_008258.1 hypothetical protein 1112376 4209390 SFV_1064 Shigella flexneri 5 str. 8401 hypothetical protein YP_688580.1 1110742 D 373384 CDS YP_688581.1 110805061 4209391 complement(1112480..1113127) 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 1113127 4209391 SFV_1065 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_688581.1 1112480 R 373384 CDS YP_688582.1 110805062 4209392 complement(1113363..1113689) 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 1113689 4209392 SFV_1066 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_688582.1 1113363 R 373384 CDS YP_688583.1 110805063 4209393 1114121..1114423 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 1114423 4209393 SFV_1067 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_688583.1 1114121 D 373384 CDS YP_688584.1 110805064 4209394 1114724..1115290 1 NC_008258.1 IS911 ORF2 1115290 4209394 SFV_1068 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_688584.1 1114724 D 373384 CDS YP_688585.1 110805065 4209395 1115863..1116228 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1116228 4209395 SFV_1069 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688585.1 1115863 D 373384 CDS YP_688586.2 162139350 4209396 1116186..1117091 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1117091 4209396 SFV_1070 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_688586.2 1116186 D 373384 CDS YP_688587.1 110805067 4209397 1117487..1117813 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 1117813 4209397 SFV_1071 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_688587.1 1117487 D 373384 CDS YP_688588.1 110805068 4209398 1118049..1118528 1 NC_008258.1 IS629 ORF2 1118528 4209398 SFV_1072 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_688588.1 1118049 D 373384 CDS YP_688589.1 110805069 4209399 1118309..1118695 1 NC_008258.1 IS629 ORF2 1118695 4209399 SFV_1073 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_688589.1 1118309 D 373384 CDS YP_688590.1 110805070 4209400 1118983..1119285 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1119285 4209400 SFV_1074 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688590.1 1118983 D 373384 CDS YP_688591.1 110805071 4209401 1119426..1120139 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1120139 4209401 SFV_1075 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688591.1 1119426 D 373384 CDS YP_688592.1 110805072 4209402 complement(1120164..1121102) 1 NC_008258.1 Code: L; COG: COG1961; hypothetical protein 1121102 4209402 SFV_1076 Shigella flexneri 5 str. 8401 hypothetical protein YP_688592.1 1120164 R 373384 CDS YP_688593.1 110805073 4209403 complement(1121489..1122472) 1 NC_008258.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1122472 htrB 4209403 htrB Shigella flexneri 5 str. 8401 lipid A biosynthesis lauroyl acyltransferase YP_688593.1 1121489 R 373384 CDS YP_688594.1 110805074 4209404 1122634..1123686 1 NC_008258.1 Code: R; COG: COG1054; hypothetical protein 1123686 yceA 4209404 yceA Shigella flexneri 5 str. 8401 hypothetical protein YP_688594.1 1122634 D 373384 CDS YP_688595.1 110805075 4209561 complement(1123728..1124303) 1 NC_008258.1 Code: S; COG: COG2353; hypothetical protein 1124303 yceI 4209561 yceI Shigella flexneri 5 str. 8401 hypothetical protein YP_688595.1 1123728 R 373384 CDS YP_688596.1 110805076 4209562 complement(1124307..1124948) 1 NC_008258.1 Code: C; COG: COG3038; cytochrome 1124948 4209562 SFV_1080 Shigella flexneri 5 str. 8401 cytochrome YP_688596.1 1124307 R 373384 CDS YP_688597.1 110805077 4209563 complement(1125134..1125274) 1 NC_008258.1 hypothetical protein 1125274 yceO 4209563 yceO Shigella flexneri 5 str. 8401 hypothetical protein YP_688597.1 1125134 R 373384 CDS YP_688598.1 110805078 4209564 complement(1125295..1126413) 1 NC_008258.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1126413 solA 4209564 solA Shigella flexneri 5 str. 8401 N-methyltryptophan oxidase YP_688598.1 1125295 R 373384 CDS YP_688599.2 229774942 4209565 complement(1127072..1127317) 1 NC_008258.1 DNA damage-inducible protein I 1127317 dinI 4209565 dinI Shigella flexneri 5 str. 8401 DNA damage-inducible protein I YP_688599.2 1127072 R 373384 CDS YP_688600.1 110805080 4209566 complement(1127391..1128437) 1 NC_008258.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1128437 pyrC 4209566 pyrC Shigella flexneri 5 str. 8401 dihydroorotase YP_688600.1 1127391 R 373384 CDS YP_688601.1 110805081 4209567 complement(1128543..1129160) 1 NC_008258.1 hypothetical protein 1129160 yceB 4209567 yceB Shigella flexneri 5 str. 8401 hypothetical protein YP_688601.1 1128543 R 373384 CDS YP_688602.1 110805082 4209568 complement(1129237..1129884) 1 NC_008258.1 cofactor involved in the reduction of disulfides; glutaredoxin 2 1129884 grxB 4209568 grxB Shigella flexneri 5 str. 8401 glutaredoxin 2 YP_688602.1 1129237 R 373384 CDS YP_688603.1 110805083 4209569 complement(1129948..1131156) 1 NC_008258.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1131156 yceL 4209569 yceL Shigella flexneri 5 str. 8401 multidrug resistance protein MdtH YP_688603.1 1129948 R 373384 CDS YP_688604.1 110805084 4209570 1131392..1131976 1 NC_008258.1 Code: J; COG: COG1670; ribosomal-protein-S5-alanine N-acetyltransferase 1131976 rimJ 4209570 rimJ Shigella flexneri 5 str. 8401 ribosomal-protein-S5-alanine N-acetyltransferase YP_688604.1 1131392 D 373384 CDS YP_688605.1 110805085 4209571 1131987..1132634 1 NC_008258.1 Code: S; COG: COG3132; hypothetical protein 1132634 yceH 4209571 yceH Shigella flexneri 5 str. 8401 hypothetical protein YP_688605.1 1131987 D 373384 CDS YP_688606.1 110805086 4209572 1132636..1133502 1 NC_008258.1 Code: R; COG: COG0673; virulence factor 1133502 mviM 4209572 mviM Shigella flexneri 5 str. 8401 virulence factor YP_688606.1 1132636 D 373384 CDS YP_688607.1 110805087 4209573 1133669..1135204 1 NC_008258.1 Code: R; COG: COG0728; virulence factor 1135204 mviN 4209573 mviN Shigella flexneri 5 str. 8401 virulence factor YP_688607.1 1133669 D 373384 CDS YP_688608.1 110805088 4209574 complement(1135244..1135660) 1 NC_008258.1 Code: NUO; COG: COG3418; flagellar synthesis protein FlgN 1135660 flgN 4209574 flgN Shigella flexneri 5 str. 8401 flagellar synthesis protein FlgN YP_688608.1 1135244 R 373384 CDS YP_688609.1 110805089 4209575 complement(1135665..1135958) 1 NC_008258.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma28 factor FlgM 1135958 flgM 4209575 flgM Shigella flexneri 5 str. 8401 anti-sigma28 factor FlgM YP_688609.1 1135665 R 373384 CDS YP_688610.1 110805090 4209576 complement(1136034..1136693) 1 NC_008258.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1136693 flgA 4209576 flgA Shigella flexneri 5 str. 8401 flagellar basal body P-ring biosynthesis protein FlgA YP_688610.1 1136034 R 373384 CDS YP_688611.1 110805091 4209577 1136848..1137264 1 NC_008258.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1137264 flgB 4209577 flgB Shigella flexneri 5 str. 8401 flagellar basal-body rod protein FlgB YP_688611.1 1136848 D 373384 CDS YP_688612.1 110805092 4209579 1137683..1138378 1 NC_008258.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1138378 flgD 4209579 flgD Shigella flexneri 5 str. 8401 flagellar basal body rod modification protein YP_688612.1 1137683 D 373384 CDS YP_688613.1 110805093 4209580 1138403..1139611 1 NC_008258.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1139611 flgE 4209580 flgE Shigella flexneri 5 str. 8401 flagellar hook protein FlgE YP_688613.1 1138403 D 373384 CDS YP_688614.1 110805094 4207997 1139631..1140386 1 NC_008258.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1140386 flgF 4207997 flgF Shigella flexneri 5 str. 8401 flagellar basal body rod protein FlgF YP_688614.1 1139631 D 373384 CDS YP_688615.1 110805095 4207998 1140524..1141306 1 NC_008258.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1141306 flgG 4207998 flgG Shigella flexneri 5 str. 8401 flagellar basal body rod protein FlgG YP_688615.1 1140524 D 373384 CDS YP_688616.1 110805096 4207999 1141350..1142057 1 NC_008258.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1142057 flgH 4207999 flgH Shigella flexneri 5 str. 8401 flagellar basal body L-ring protein YP_688616.1 1141350 D 373384 CDS YP_688617.1 110805097 4208000 1142069..1143166 1 NC_008258.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring biosynthesis protein FlgA 1143166 flgI 4208000 flgI Shigella flexneri 5 str. 8401 flagellar basal body P-ring biosynthesis protein FlgA YP_688617.1 1142069 D 373384 CDS YP_688618.2 162139349 4208001 1143166..1144107 1 NC_008258.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1144107 flgJ 4208001 flgJ Shigella flexneri 5 str. 8401 flagellar rod assembly protein/muramidase FlgJ YP_688618.2 1143166 D 373384 CDS YP_688619.1 110805099 4208003 1145827..1146780 1 NC_008258.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1146780 flgL 4208003 flgL Shigella flexneri 5 str. 8401 flagellar hook-associated protein FlgL YP_688619.1 1145827 D 373384 CDS YP_688620.1 110805100 4208004 complement(1146976..1150161) 1 NC_008258.1 membrane attachment, mRNA turnover, maturation 5S RNA; bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1150161 rne 4208004 rne Shigella flexneri 5 str. 8401 ribonuclease E YP_688620.1 1146976 R 373384 CDS YP_688621.1 110805101 4208005 1150734..1151693 1 NC_008258.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1151693 yceC 4208005 yceC Shigella flexneri 5 str. 8401 23S rRNA pseudouridylate synthase C YP_688621.1 1150734 D 373384 CDS YP_688622.1 110805102 4208006 complement(1151805..1152428) 1 NC_008258.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1152428 yceF 4208006 yceF Shigella flexneri 5 str. 8401 Maf-like protein YP_688622.1 1151805 R 373384 CDS YP_688623.1 110805103 4208007 1152588..1153109 1 NC_008258.1 Code: R; COG: COG1399; hypothetical protein 1153109 yceD 4208007 yceD Shigella flexneri 5 str. 8401 hypothetical protein YP_688623.1 1152588 D 373384 CDS YP_688624.1 110805104 4208008 1153469..1154485 1 NC_008258.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1154485 plsX 4208008 plsX Shigella flexneri 5 str. 8401 glycerol-3-phosphate acyltransferase PlsX YP_688624.1 1153469 D 373384 CDS YP_688625.1 110805105 4208009 1154553..1155506 1 NC_008258.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1155506 fabH 4208009 fabH Shigella flexneri 5 str. 8401 3-oxoacyl-ACP synthase YP_688625.1 1154553 D 373384 CDS YP_688626.1 110805106 4208010 1155522..1156451 1 NC_008258.1 Code: I; COG: COG0331; ACP S-malonyltransferase 1156451 fabD 4208010 fabD Shigella flexneri 5 str. 8401 ACP S-malonyltransferase YP_688626.1 1155522 D 373384 CDS YP_688627.1 110805107 4208011 1156464..1157198 1 NC_008258.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1157198 fabG 4208011 fabG Shigella flexneri 5 str. 8401 3-ketoacyl-ACP reductase YP_688627.1 1156464 D 373384 CDS YP_688628.1 110805108 4208012 1157409..1157645 1 NC_008258.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1157645 acpP 4208012 acpP Shigella flexneri 5 str. 8401 acyl carrier protein YP_688628.1 1157409 D 373384 CDS YP_688629.2 229774941 4208013 1157731..1158972 1 NC_008258.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1158972 fabF 4208013 fabF Shigella flexneri 5 str. 8401 3-oxoacyl-ACP synthase YP_688629.2 1157731 D 373384 CDS YP_688630.1 110805110 4208014 1159092..1159901 1 NC_008258.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1159901 pabC 4208014 pabC Shigella flexneri 5 str. 8401 4-amino-4-deoxychorismate lyase YP_688630.1 1159092 D 373384 CDS YP_688631.1 110805111 4208015 1159904..1160926 1 NC_008258.1 Code: R; COG: COG1559; hypothetical protein 1160926 yceG 4208015 yceG Shigella flexneri 5 str. 8401 hypothetical protein YP_688631.1 1159904 D 373384 CDS YP_688632.1 110805112 4208224 1160916..1161557 1 NC_008258.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1161557 tmk 4208224 tmk Shigella flexneri 5 str. 8401 thymidylate kinase YP_688632.1 1160916 D 373384 CDS YP_688633.1 110805113 4208225 1161554..1162558 1 NC_008258.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1162558 holB 4208225 holB Shigella flexneri 5 str. 8401 DNA polymerase III subunit delta' YP_688633.1 1161554 D 373384 CDS YP_688634.1 110805114 4208226 1162569..1163366 1 NC_008258.1 Code: L; COG: COG0084; metallodependent hydrolase 1163366 ycfH 4208226 ycfH Shigella flexneri 5 str. 8401 metallodependent hydrolase YP_688634.1 1162569 D 373384 CDS YP_688635.1 110805115 4208227 1163661..1165094 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunits IIBC 1165094 ptsG 4208227 ptsG Shigella flexneri 5 str. 8401 PTS system glucose-specific transporter subunits IIBC YP_688635.1 1163661 D 373384 CDS YP_688636.1 110805116 4208228 complement(1165154..1167343) 1 NC_008258.1 Code: P; COG: COG4773; ferric-rhodotorulic acid outer membrane transporter 1167343 fhuE 4208228 fhuE Shigella flexneri 5 str. 8401 ferric-rhodotorulic acid outer membrane transporter YP_688636.1 1165154 R 373384 CDS YP_688637.1 110805117 4208229 1167682..1168041 1 NC_008258.1 Code: FGR; COG: COG0537; purine nucleoside phosphoramidase 1168041 ycfF 4208229 ycfF Shigella flexneri 5 str. 8401 purine nucleoside phosphoramidase YP_688637.1 1167682 D 373384 CDS YP_688638.1 110805118 4208230 1168044..1168421 1 NC_008258.1 Code: R; COG: COG5633; hypothetical protein 1168421 ycfL 4208230 ycfL Shigella flexneri 5 str. 8401 hypothetical protein YP_688638.1 1168044 D 373384 CDS YP_688639.1 110805119 4208231 1168436..1169017 1 NC_008258.1 Code: R; COG: COG3417; hypothetical protein 1169017 ycfM 4208231 ycfM Shigella flexneri 5 str. 8401 hypothetical protein YP_688639.1 1168436 D 373384 CDS YP_688640.1 110805120 4208232 1169057..1169881 1 NC_008258.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1169881 thiK 4208232 thiK Shigella flexneri 5 str. 8401 thiamine kinase YP_688640.1 1169057 D 373384 CDS YP_688641.1 110805121 4208233 1169904..1170917 1 NC_008258.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1170917 ycfO 4208233 ycfO Shigella flexneri 5 str. 8401 beta-hexosaminidase YP_688641.1 1169904 D 373384 CDS YP_688642.1 110805122 4208234 1170940..1171482 1 NC_008258.1 Code: R; COG: COG3150; hypothetical protein 1171482 ycfP 4208234 ycfP Shigella flexneri 5 str. 8401 hypothetical protein YP_688642.1 1170940 D 373384 CDS YP_688643.1 110805123 4208235 1171914..1173194 1 NC_008258.1 Code: C; COG: COG1252; respiratory NADH dehydrogenase 1173194 ndh 4208235 ndh Shigella flexneri 5 str. 8401 respiratory NADH dehydrogenase YP_688643.1 1171914 D 373384 CDS YP_688644.1 110805124 4208236 1173433..1173960 1 NC_008258.1 Code: S; COG: COG3134; hypothetical protein 1173960 ycfJ 4208236 ycfJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688644.1 1173433 D 373384 CDS YP_688645.1 110805125 4208237 complement(1174022..1174717) 1 NC_008258.1 Code: K; COG: COG1309; hypothetical protein 1174717 ycfQ 4208237 ycfQ Shigella flexneri 5 str. 8401 hypothetical protein YP_688645.1 1174022 R 373384 CDS YP_688646.1 110805126 4208238 1174939..1175151 1 NC_008258.1 hypothetical protein 1175151 ycfR 4208238 ycfR Shigella flexneri 5 str. 8401 hypothetical protein YP_688646.1 1174939 D 373384 CDS YP_688647.1 110805127 4208239 complement(1175234..1176199) 1 NC_008258.1 Code: S; COG: COG1376; hypothetical protein 1176199 ycfS 4208239 ycfS Shigella flexneri 5 str. 8401 hypothetical protein YP_688647.1 1175234 R 373384 CDS YP_688648.1 110805128 4208240 complement(1176339..1179848) 1 NC_008258.1 Code: LK; COG: COG1197; transcription-repair coupling factor 1179848 mfd 4208240 mfd Shigella flexneri 5 str. 8401 transcription-repair coupling factor YP_688648.1 1176339 R 373384 CDS YP_688649.1 110805129 4208241 complement(1179913..1180986) 1 NC_008258.1 Code: S; COG: COG4763; hypothetical protein 1180986 ycfT 4208241 ycfT Shigella flexneri 5 str. 8401 hypothetical protein YP_688649.1 1179913 R 373384 CDS YP_688650.1 110805130 4208242 1181197..1182447 1 NC_008258.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1182447 ycfU 4208242 ycfU Shigella flexneri 5 str. 8401 outer membrane-specific lipoprotein transporter subunit LolC YP_688650.1 1181197 D 373384 CDS YP_688651.1 110805131 4208243 1182455..1183141 1 NC_008258.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1183141 lolD 4208243 lolD Shigella flexneri 5 str. 8401 lipoprotein transporter ATP-binding subunit YP_688651.1 1182455 D 373384 CDS YP_688652.1 110805132 4208952 1183141..1184385 1 NC_008258.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1184385 ycfW 4208952 ycfW Shigella flexneri 5 str. 8401 outer membrane-specific lipoprotein transporter subunit LolE YP_688652.1 1183141 D 373384 CDS YP_688653.1 110805133 4208953 1184414..1185325 1 NC_008258.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1185325 ycfX 4208953 ycfX Shigella flexneri 5 str. 8401 N-acetyl-D-glucosamine kinase YP_688653.1 1184414 D 373384 CDS YP_688654.1 110805134 4208954 1185341..1186162 1 NC_008258.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1186162 cobB 4208954 cobB Shigella flexneri 5 str. 8401 NAD-dependent deacetylase YP_688654.1 1185341 D 373384 CDS YP_688655.1 110805135 4208955 complement(1186318..1187364) 1 NC_008258.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter periplasmic substrate-binding protein 1187364 potD 4208955 potD Shigella flexneri 5 str. 8401 spermidine/putrescine ABC transporter periplasmic substrate-binding protein YP_688655.1 1186318 R 373384 CDS YP_688656.1 110805136 4208956 complement(1187361..1188155) 1 NC_008258.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1188155 potC 4208956 potC Shigella flexneri 5 str. 8401 spermidine/putrescine ABC transporter membrane protein YP_688656.1 1187361 R 373384 CDS YP_688657.1 110805137 4208957 complement(1188152..1189009) 1 NC_008258.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1189009 potB 4208957 potB Shigella flexneri 5 str. 8401 spermidine/putrescine ABC transporter membrane protein YP_688657.1 1188152 R 373384 CDS YP_688658.1 110805138 4208958 complement(1188993..1190129) 1 NC_008258.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1190129 potA 4208958 potA Shigella flexneri 5 str. 8401 putrescine/spermidine ABC transporter ATPase YP_688658.1 1188993 R 373384 CDS YP_688659.1 110805139 4208959 1190379..1191605 1 NC_008258.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1191605 pepT 4208959 pepT Shigella flexneri 5 str. 8401 peptidase T YP_688659.1 1190379 D 373384 CDS YP_688660.1 110805140 4208960 complement(1191654..1192784) 1 NC_008258.1 Code: S; COG: COG2850; hypothetical protein 1192784 ycfD 4208960 ycfD Shigella flexneri 5 str. 8401 hypothetical protein YP_688660.1 1191654 R 373384 CDS YP_688661.1 110805141 4208961 1193003..1194253 1 NC_008258.1 Code: L; COG: COG0582; integrase of prophage 1194253 4208961 SFV_1147 Shigella flexneri 5 str. 8401 integrase of prophage YP_688661.1 1193003 D 373384 CDS YP_688662.1 110805142 4208962 1194874..1195620 1 NC_008258.1 hypothetical protein 1195620 4208962 SFV_1148 Shigella flexneri 5 str. 8401 hypothetical protein YP_688662.1 1194874 D 373384 CDS YP_688663.1 110805143 4208963 1196494..1196793 1 NC_008258.1 hypothetical protein 1196793 4208963 SFV_1149 Shigella flexneri 5 str. 8401 hypothetical protein YP_688663.1 1196494 D 373384 CDS YP_688664.1 110805144 4208964 1196790..1198538 1 NC_008258.1 Code: R; COG: COG3378; bacteriophage P4 DNA primase 1198538 4208964 SFV_1150 Shigella flexneri 5 str. 8401 bacteriophage P4 DNA primase YP_688664.1 1196790 D 373384 CDS YP_688665.1 110805145 4208965 1199102..1199407 1 NC_008258.1 hypothetical protein 1199407 4208965 SFV_1151 Shigella flexneri 5 str. 8401 hypothetical protein YP_688665.1 1199102 D 373384 CDS YP_688666.1 110805146 4208966 1199417..1199578 1 NC_008258.1 hypothetical protein 1199578 4208966 SFV_1152 Shigella flexneri 5 str. 8401 hypothetical protein YP_688666.1 1199417 D 373384 CDS YP_688667.1 110805147 4208967 1199642..1199944 1 NC_008258.1 hypothetical protein 1199944 4208967 SFV_1153 Shigella flexneri 5 str. 8401 hypothetical protein YP_688667.1 1199642 D 373384 CDS YP_688668.1 110805148 4208968 complement(1200272..1200775) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1200775 insB 4208968 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688668.1 1200272 R 373384 CDS YP_688669.1 110805149 4208969 1200850..1201065 1 NC_008258.1 IS1 encoded protein 1201065 4208969 SFV_1155 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688669.1 1200850 D 373384 CDS YP_688670.1 110805150 4209099 1202234..1202791 1 NC_008258.1 Code: R; COG: COG3740; head maturation protease of prophage CP-933C 1202791 4209099 SFV_1157 Shigella flexneri 5 str. 8401 head maturation protease of prophage CP-933C YP_688670.1 1202234 D 373384 CDS YP_688671.1 110805151 4209100 1202793..1204004 1 NC_008258.1 Code: S; COG: COG4695; head portal protein 1204004 4209100 SFV_1158 Shigella flexneri 5 str. 8401 head portal protein YP_688671.1 1202793 D 373384 CDS YP_688672.1 110805152 4209101 1204336..1204632 1 NC_008258.1 hypothetical protein 1204632 4209101 SFV_1159 Shigella flexneri 5 str. 8401 hypothetical protein YP_688672.1 1204336 D 373384 CDS YP_688673.1 110805153 4209102 1205309..1205620 1 NC_008258.1 Code: L; COG: COG3747; hypothetical protein 1205620 4209102 SFV_1160 Shigella flexneri 5 str. 8401 hypothetical protein YP_688673.1 1205309 D 373384 CDS YP_688674.1 110805154 4209103 1205604..1207265 1 NC_008258.1 Code: R; COG: COG4626; terminase of prophage CP-933C 1207265 4209103 SFV_1161 Shigella flexneri 5 str. 8401 terminase of prophage CP-933C YP_688674.1 1205604 D 373384 CDS YP_688675.1 110805155 4209104 1207279..1207560 1 NC_008258.1 hypothetical protein 1207560 4209104 SFV_1162 Shigella flexneri 5 str. 8401 hypothetical protein YP_688675.1 1207279 D 373384 CDS YP_688676.1 110805156 4209105 complement(1207867..1208043) 1 NC_008258.1 hypothetical protein 1208043 4209105 SFV_1163 Shigella flexneri 5 str. 8401 hypothetical protein YP_688676.1 1207867 R 373384 CDS YP_688677.1 110805157 4209106 complement(1208357..1209817) 1 NC_008258.1 Code: T; COG: COG0642; sensor protein PhoQ 1209817 phoQ 4209106 phoQ Shigella flexneri 5 str. 8401 sensor protein PhoQ YP_688677.1 1208357 R 373384 CDS YP_688678.1 110805158 4209107 complement(1209817..1210488) 1 NC_008258.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1210488 phoP 4209107 phoP Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator PhoP YP_688678.1 1209817 R 373384 CDS YP_688679.1 110805159 4209108 complement(1210657..1212027) 1 NC_008258.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1212027 purB 4209108 purB Shigella flexneri 5 str. 8401 adenylosuccinate lyase YP_688679.1 1210657 R 373384 CDS YP_688680.1 110805160 4209109 complement(1212031..1212672) 1 NC_008258.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1212672 ycfC 4209109 ycfC Shigella flexneri 5 str. 8401 hypothetical protein YP_688680.1 1212031 R 373384 CDS YP_688681.1 110805161 4209110 complement(1212708..1213814) 1 NC_008258.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1213814 mnmA 4209110 mnmA Shigella flexneri 5 str. 8401 tRNA-specific 2-thiouridylase MnmA YP_688681.1 1212708 R 373384 CDS YP_688682.1 110805162 4209111 complement(1213868..1214329) 1 NC_008258.1 Code: LR; COG: COG0494; phosphohydrolase 1214329 4209111 SFV_1169 Shigella flexneri 5 str. 8401 phosphohydrolase YP_688682.1 1213868 R 373384 CDS YP_688683.1 110805163 4209112 complement(1214339..1214992) 1 NC_008258.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1214992 ymfC 4209112 ymfC Shigella flexneri 5 str. 8401 23S rRNA pseudouridine synthase E YP_688683.1 1214339 R 373384 CDS YP_688684.1 110805164 4209113 1215164..1216414 1 NC_008258.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1216414 icdA 4209113 icdA Shigella flexneri 5 str. 8401 isocitrate dehydrogenase YP_688684.1 1215164 D 373384 CDS YP_688685.1 110805165 4209114 complement(1216521..1217024) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1217024 insB 4209114 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688685.1 1216521 R 373384 CDS YP_688686.1 110805166 4209115 1217099..1217332 1 NC_008258.1 IS1 encoded protein 1217332 4209115 SFV_1173 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688686.1 1217099 D 373384 CDS YP_688687.1 110805167 4209116 1217756..1220029 1 NC_008258.1 hypothetical protein 1220029 4209116 SFV_1174 Shigella flexneri 5 str. 8401 hypothetical protein YP_688687.1 1217756 D 373384 CDS YP_688688.1 110805168 4209117 complement(1220086..1220415) 1 NC_008258.1 hypothetical protein 1220415 4209117 SFV_1175 Shigella flexneri 5 str. 8401 hypothetical protein YP_688688.1 1220086 R 373384 CDS YP_688689.1 110805169 4209118 complement(1220425..1220769) 1 NC_008258.1 hypothetical protein 1220769 4209118 SFV_1176 Shigella flexneri 5 str. 8401 hypothetical protein YP_688689.1 1220425 R 373384 CDS YP_688690.1 110805170 4209405 1221279..1221689 1 NC_008258.1 hypothetical protein 1221689 4209405 SFV_1177 Shigella flexneri 5 str. 8401 hypothetical protein YP_688690.1 1221279 D 373384 CDS YP_688691.1 110805171 4209406 complement(1222061..1222327) 1 NC_008258.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1222327 minE 4209406 minE Shigella flexneri 5 str. 8401 cell division topological specificity factor MinE YP_688691.1 1222061 R 373384 CDS YP_688692.1 110805172 4209407 complement(1222331..1223143) 1 NC_008258.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1223143 minD 4209407 minD Shigella flexneri 5 str. 8401 cell division inhibitor MinD YP_688692.1 1222331 R 373384 CDS YP_688693.2 162139348 4209408 complement(1223167..1223862) 1 NC_008258.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1223862 minC 4209408 minC Shigella flexneri 5 str. 8401 septum formation inhibitor YP_688693.2 1223167 R 373384 CDS YP_688694.2 162139347 4209409 complement(1224602..1225507) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1225507 4209409 SFV_1181 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_688694.2 1224602 R 373384 CDS YP_688695.1 110805175 4209410 complement(1225465..1225830) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1225830 4209410 SFV_1182 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688695.1 1225465 R 373384 CDS YP_688696.1 110805176 4209411 complement(1226194..1226412) 1 NC_008258.1 hypothetical protein 1226412 4209411 SFV_1183 Shigella flexneri 5 str. 8401 hypothetical protein YP_688696.1 1226194 R 373384 CDS YP_688697.1 110805177 4209412 1226557..1226856 1 NC_008258.1 Code: L; COG: COG2963; IS3 ORF1 1226856 4209412 SFV_1184 Shigella flexneri 5 str. 8401 IS3 ORF1 YP_688697.1 1226557 D 373384 CDS YP_688698.1 110805178 4209413 1226853..1227707 1 NC_008258.1 Code: L; COG: COG2801; IS3 ORF2 1227707 4209413 SFV_1185 Shigella flexneri 5 str. 8401 IS3 ORF2 YP_688698.1 1226853 D 373384 CDS YP_688699.1 110805179 4209414 1228065..1228391 1 NC_008258.1 Code: S; COG: COG3100; hypothetical protein 1228391 ycgL 4209414 ycgL Shigella flexneri 5 str. 8401 hypothetical protein YP_688699.1 1228065 D 373384 CDS YP_688700.1 110805180 4209415 1228463..1229122 1 NC_008258.1 Code: Q; COG: COG0179; hypothetical protein 1229122 4209415 SFV_1187 Shigella flexneri 5 str. 8401 hypothetical protein YP_688700.1 1228463 D 373384 CDS YP_688701.2 162139346 4209416 1229214..1229660 1 NC_008258.1 Code: S; COG: COG2983; hypothetical protein 1229660 ycgN 4209416 ycgN Shigella flexneri 5 str. 8401 hypothetical protein YP_688701.2 1229214 D 373384 CDS YP_688702.1 110805182 4209418 1231140..1231559 1 NC_008258.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1231559 umuD 4209418 umuD Shigella flexneri 5 str. 8401 DNA polymerase V subunit UmuD YP_688702.1 1231140 D 373384 CDS YP_688703.1 110805183 4209419 1231559..1232827 1 NC_008258.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1232827 umuC 4209419 umuC Shigella flexneri 5 str. 8401 DNA polymerase V subunit UmuC YP_688703.1 1231559 D 373384 CDS YP_688704.1 110805184 4209420 complement(1232873..1233403) 1 NC_008258.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1233403 dsbB 4209420 dsbB Shigella flexneri 5 str. 8401 disulfide bond formation protein B YP_688704.1 1232873 R 373384 CDS YP_688705.1 110805185 4209421 complement(1233549..1235090) 1 NC_008258.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1235090 nhaB 4209421 nhaB Shigella flexneri 5 str. 8401 sodium/proton antiporter YP_688705.1 1233549 R 373384 CDS YP_688706.1 110805186 4209422 1235287..1236030 1 NC_008258.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1236030 fadR 4209422 fadR Shigella flexneri 5 str. 8401 fatty acid metabolism regulator YP_688706.1 1235287 D 373384 CDS YP_688707.1 110805187 4209423 complement(1236082..1237614) 1 NC_008258.1 Code: S; COG: COG2719; SpoVR family protein 1237614 ycgB 4209423 ycgB Shigella flexneri 5 str. 8401 SpoVR family protein YP_688707.1 1236082 R 373384 CDS YP_688708.1 110805188 4209443 1237944..1239242 1 NC_008258.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1239242 dadA 4209443 dadA Shigella flexneri 5 str. 8401 D-amino acid dehydrogenase small subunit YP_688708.1 1237944 D 373384 CDS YP_688709.1 110805189 4209444 1239252..1240322 1 NC_008258.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1240322 dadX 4209444 dadX Shigella flexneri 5 str. 8401 alanine racemase YP_688709.1 1239252 D 373384 CDS YP_688710.1 110805190 4209445 complement(1240754..1241788) 1 NC_008258.1 possible fragment; invasion plasmid antigen 1241788 ipaH 4209445 ipaH Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_688710.1 1240754 R 373384 CDS YP_688711.1 110805191 4209446 complement(1242515..1244251) 1 NC_008258.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1244251 4209446 SFV_1199 Shigella flexneri 5 str. 8401 potassium/proton antiporter YP_688711.1 1242515 R 373384 CDS YP_688712.1 110805193 4209448 complement(1244346..1245260) 1 NC_008258.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1245260 ldcA 4209448 ldcA Shigella flexneri 5 str. 8401 L,D-carboxypeptidase A YP_688712.1 1244346 R 373384 CDS YP_688713.1 110805192 4209447 1245246..1245971 1 NC_008258.1 Code: M; COG: COG0741; murein transglycosylase E 1245971 mltE 4209447 mltE Shigella flexneri 5 str. 8401 murein transglycosylase E YP_688713.1 1245246 D 373384 CDS YP_688714.1 110805194 4209449 complement(1245973..1246707) 1 NC_008258.1 Code: M; COG: COG5581; hypothetical protein 1246707 ycgR 4209449 ycgR Shigella flexneri 5 str. 8401 hypothetical protein YP_688714.1 1245973 R 373384 CDS YP_688715.1 110805195 4209450 1246875..1247162 1 NC_008258.1 Code: S; COG: COG2261; hypothetical protein 1247162 ymgE 4209450 ymgE Shigella flexneri 5 str. 8401 hypothetical protein YP_688715.1 1246875 D 373384 CDS YP_688716.1 110805196 4209452 complement(1249194..1250048) 1 NC_008258.1 involved in molybdenum transport; molybdenum transport protein ModD 1250048 modD 4209452 modD Shigella flexneri 5 str. 8401 molybdenum transport protein ModD YP_688716.1 1249194 R 373384 CDS YP_688717.1 110805197 4209453 complement(1250048..1250752) 1 NC_008258.1 Code: QR; COG: COG0500; hypothetical protein 1250752 4209453 SFV_1206 Shigella flexneri 5 str. 8401 hypothetical protein YP_688717.1 1250048 R 373384 CDS YP_688718.1 110805198 4209454 complement(1250867..1251625) 1 NC_008258.1 Code: PH; COG: COG1120; iron ABC transporter ATP-binding protein 1251625 4209454 SFV_1207 Shigella flexneri 5 str. 8401 iron ABC transporter ATP-binding protein YP_688718.1 1250867 R 373384 CDS YP_688719.1 110805199 4209455 complement(1251622..1252602) 1 NC_008258.1 Code: P; COG: COG0609; iron compound ABC transporter permease 1252602 4209455 SFV_1208 Shigella flexneri 5 str. 8401 iron compound ABC transporter permease YP_688719.1 1251622 R 373384 CDS YP_688720.1 110805200 4209456 complement(1252602..1253624) 1 NC_008258.1 Code: P; COG: COG0614; ATP-binding protein of ABC transporter 1253624 4209456 SFV_1209 Shigella flexneri 5 str. 8401 ATP-binding protein of ABC transporter YP_688720.1 1252602 R 373384 CDS YP_688721.1 110805201 4209457 1254164..1254976 1 NC_008258.1 hypothetical protein 1254976 4209457 SFV_1210 Shigella flexneri 5 str. 8401 hypothetical protein YP_688721.1 1254164 D 373384 CDS YP_688722.1 110805202 4209458 complement(1255207..1256904) 1 NC_008258.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1256904 treA 4209458 treA Shigella flexneri 5 str. 8401 trehalase YP_688722.1 1255207 R 373384 CDS YP_688723.1 110805203 4209459 complement(1257224..1258573) 1 NC_008258.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit M 1258573 ycgC 4209459 ycgC Shigella flexneri 5 str. 8401 dihydroxyacetone kinase subunit M YP_688723.1 1257224 R 373384 CDS YP_688724.1 110805204 4209460 complement(1258653..1259285) 1 NC_008258.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1259285 4209460 SFV_1213 Shigella flexneri 5 str. 8401 dihydroxyacetone kinase subunit DhaL YP_688724.1 1258653 R 373384 CDS YP_688725.1 110805205 4209461 complement(1259296..1260366) 1 NC_008258.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1260366 4209461 SFV_1214 Shigella flexneri 5 str. 8401 dihydroxyacetone kinase subunit DhaK YP_688725.1 1259296 R 373384 CDS YP_688726.1 110805206 4209462 1260672..1262513 1 NC_008258.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1262513 4209462 SFV_1215 Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator DhaR YP_688726.1 1260672 D 373384 CDS YP_688727.1 110805207 4209581 complement(1262613..1265480) 1 NC_008258.1 adhesion and penetration protein 1265480 4209581 SFV_1216 Shigella flexneri 5 str. 8401 adhesion and penetration protein YP_688727.1 1262613 R 373384 CDS YP_688728.1 110805208 4209582 complement(1266324..1267415) 1 NC_008258.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1267415 ychF 4209582 ychF Shigella flexneri 5 str. 8401 GTP-dependent nucleic acid-binding protein EngD YP_688728.1 1266324 R 373384 CDS YP_688729.1 110805209 4209583 complement(1267532..1268116) 1 NC_008258.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1268116 pth 4209583 pth Shigella flexneri 5 str. 8401 peptidyl-tRNA hydrolase YP_688729.1 1267532 R 373384 CDS YP_688730.1 110805210 4209584 1268394..1268672 1 NC_008258.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1268672 ychH 4209584 ychH Shigella flexneri 5 str. 8401 hypothetical protein YP_688730.1 1268394 D 373384 CDS YP_688731.1 110805211 4209585 complement(1268727..1270379) 1 NC_008258.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 1270379 ychM 4209585 ychM Shigella flexneri 5 str. 8401 sulfate transporter YchM YP_688731.1 1268727 R 373384 CDS YP_688732.1 110805212 4209586 complement(1270531..1271544) 1 NC_008258.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1271544 prsA 4209586 prsA Shigella flexneri 5 str. 8401 ribose-phosphate pyrophosphokinase YP_688732.1 1270531 R 373384 CDS YP_688733.1 110805213 4209587 complement(1271629..1272480) 1 NC_008258.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1272480 ipk 4209587 ipk Shigella flexneri 5 str. 8401 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_688733.1 1271629 R 373384 CDS YP_688734.1 110805214 4209588 complement(1272480..1273103) 1 NC_008258.1 an enzyme in main pathway of synthesis of 5-aminolevulinate; Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; molecular chaperone LolB 1273103 lolB 4209588 lolB Shigella flexneri 5 str. 8401 molecular chaperone LolB YP_688734.1 1272480 R 373384 CDS YP_688735.1 110805215 4209589 1273119..1274573 1 NC_008258.1 enzyme in alternate path of synthesis of 5-aminolevulinate; catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1274573 hemA 4209589 hemA Shigella flexneri 5 str. 8401 glutamyl-tRNA reductase YP_688735.1 1273119 D 373384 CDS YP_688736.1 110805216 4209590 1274615..1275697 1 NC_008258.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1275697 prfA 4209590 prfA Shigella flexneri 5 str. 8401 peptide chain release factor 1 YP_688736.1 1274615 D 373384 CDS YP_688737.1 110805217 4209591 1275697..1276530 1 NC_008258.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1276530 hemK 4209591 hemK Shigella flexneri 5 str. 8401 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_688737.1 1275697 D 373384 CDS YP_688738.1 110805218 4209592 1276527..1276919 1 NC_008258.1 Code: S; COG: COG3094; transcriptional regulator 1276919 4209592 SFV_1227 Shigella flexneri 5 str. 8401 transcriptional regulator YP_688738.1 1276527 D 373384 CDS YP_688739.1 110805219 4209593 1276923..1277732 1 NC_008258.1 Code: S; COG: COG2912; transcriptional regulator 1277732 ychA 4209593 ychA Shigella flexneri 5 str. 8401 transcriptional regulator YP_688739.1 1276923 D 373384 CDS YP_688740.1 110805220 4209594 1277768..1278622 1 NC_008258.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1278622 kdsA 4209594 kdsA Shigella flexneri 5 str. 8401 2-dehydro-3-deoxyphosphooctonate aldolase YP_688740.1 1277768 D 373384 CDS YP_688741.1 110805221 4209595 complement(1278996..1280342) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 1280342 4209595 SFV_1230 Shigella flexneri 5 str. 8401 IS4 orf YP_688741.1 1278996 R 373384 CDS YP_688742.1 110805222 4209596 complement(1280744..1280878) 1 NC_008258.1 hypothetical protein 1280878 4209596 SFV_1231 Shigella flexneri 5 str. 8401 hypothetical protein YP_688742.1 1280744 R 373384 CDS YP_688743.1 110805223 4209597 complement(1281256..1282443) 1 NC_008258.1 Code: P; COG: COG0387; calcium/sodium:proton antiporter 1282443 chaA 4209597 chaA Shigella flexneri 5 str. 8401 calcium/sodium:proton antiporter YP_688743.1 1281256 R 373384 CDS YP_688744.1 110805224 4209598 1282626..1282856 1 NC_008258.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1282856 chaB 4209598 chaB Shigella flexneri 5 str. 8401 cation transport regulator YP_688744.1 1282626 D 373384 CDS YP_688745.1 110805225 4209599 1282993..1283709 1 NC_008258.1 Code: P; COG: COG3703; cation transport regulator 1283709 chaC 4209599 chaC Shigella flexneri 5 str. 8401 cation transport regulator YP_688745.1 1282993 D 373384 CDS YP_688746.1 110805226 4209654 complement(1283753..1284106) 1 NC_008258.1 Code: P; COG: COG1553; hypothetical protein 1284106 ychN 4209654 ychN Shigella flexneri 5 str. 8401 hypothetical protein YP_688746.1 1283753 R 373384 CDS YP_688747.1 110805227 4209655 1284431..1285684 1 NC_008258.1 hypothetical protein 1285684 ychP 4209655 ychP Shigella flexneri 5 str. 8401 hypothetical protein YP_688747.1 1284431 D 373384 CDS YP_688748.1 110805228 4209656 complement(1285685..1286335) 1 NC_008258.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1286335 narL 4209656 narL Shigella flexneri 5 str. 8401 transcriptional regulator NarL YP_688748.1 1285685 R 373384 CDS YP_688749.1 110805229 4209657 complement(1286328..1288124) 1 NC_008258.1 acts on NarL regulator; Code: T; COG: COG3850; nitrate/nitrite sensor protein NarX 1288124 narX 4209657 narX Shigella flexneri 5 str. 8401 nitrate/nitrite sensor protein NarX YP_688749.1 1286328 R 373384 CDS YP_688750.1 110805230 4209658 1288463..1289854 1 NC_008258.1 Code: P; COG: COG2223; nitrate transport protein nark 1289854 narK 4209658 narK Shigella flexneri 5 str. 8401 nitrate transport protein nark YP_688750.1 1288463 D 373384 CDS YP_688751.1 110805231 4209659 1290247..1293990 1 NC_008258.1 Code: C; COG: COG5013; nitrate reductase 1 subunit alpha 1293990 narG 4209659 narG Shigella flexneri 5 str. 8401 nitrate reductase 1 subunit alpha YP_688751.1 1290247 D 373384 CDS YP_688752.1 110805232 4209660 1293987..1295525 1 NC_008258.1 Code: C; COG: COG1140; nitrate reductase 1 subunit beta 1295525 narH 4209660 narH Shigella flexneri 5 str. 8401 nitrate reductase 1 subunit beta YP_688752.1 1293987 D 373384 CDS YP_688753.1 110805233 4209661 1295522..1296232 1 NC_008258.1 Code: C; COG: COG2180; nitrate reductase 1 subunit delta 1296232 narJ 4209661 narJ Shigella flexneri 5 str. 8401 nitrate reductase 1 subunit delta YP_688753.1 1295522 D 373384 CDS YP_688754.1 110805234 4209662 1296232..1296909 1 NC_008258.1 Code: C; COG: COG2181; nitrate reductase 1, cytochrome b(NR) subunit gamma 1296909 narI 4209662 narI Shigella flexneri 5 str. 8401 nitrate reductase 1, cytochrome b(NR) subunit gamma YP_688754.1 1296232 D 373384 CDS YP_688755.1 110805235 4209664 complement(1297515..1298357) 1 NC_008258.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1298357 purU 4209664 purU Shigella flexneri 5 str. 8401 formyltetrahydrofolate deformylase YP_688755.1 1297515 R 373384 CDS YP_688756.1 110805236 4209665 complement(1298407..1298865) 1 NC_008258.1 Code: S; COG: COG3012; hypothetical protein 1298865 ychJ 4209665 ychJ Shigella flexneri 5 str. 8401 hypothetical protein YP_688756.1 1298407 R 373384 CDS YP_688757.1 110805237 4209666 1298978..1299883 1 NC_008258.1 Code: R; COG: COG1752; hypothetical protein 1299883 ychK 4209666 ychK Shigella flexneri 5 str. 8401 hypothetical protein YP_688757.1 1298978 D 373384 CDS YP_688758.1 110805238 4209667 1299975..1300988 1 NC_008258.1 response regulator of RpoS 1300988 hnr 4209667 hnr Shigella flexneri 5 str. 8401 response regulator of RpoS YP_688758.1 1299975 D 373384 CDS YP_688759.1 110805239 4209668 1301190..1302098 1 NC_008258.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1302098 galU 4209668 galU Shigella flexneri 5 str. 8401 UTP-glucose-1-phosphate uridylyltransferase YP_688759.1 1301190 D 373384 CDS YP_688760.1 110805240 4209669 complement(1302242..1302655) 1 NC_008258.1 Code: R; COG: COG2916; global DNA-binding transcriptional dual regulator H-NS 1302655 hns 4209669 hns Shigella flexneri 5 str. 8401 global DNA-binding transcriptional dual regulator H-NS YP_688760.1 1302242 R 373384 CDS YP_688761.1 110805241 4209670 1303260..1303877 1 NC_008258.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1303877 tdk 4209670 tdk Shigella flexneri 5 str. 8401 thymidine kinase YP_688761.1 1303260 D 373384 CDS YP_688762.1 110805242 4209671 complement(1304163..1305509) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 1305509 4209671 SFV_1252 Shigella flexneri 5 str. 8401 IS4 orf YP_688762.1 1304163 R 373384 CDS YP_688763.1 110805243 4209672 complement(1305617..1308292) 1 NC_008258.1 Code: C; COG: COG1012; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1308292 adhE 4209672 adhE Shigella flexneri 5 str. 8401 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_688763.1 1305617 R 373384 CDS YP_688764.1 110805244 4209747 1308769..1309416 1 NC_008258.1 Code: U; COG: COG2095; hypothetical protein 1309416 ychE 4209747 ychE Shigella flexneri 5 str. 8401 hypothetical protein YP_688764.1 1308769 D 373384 CDS YP_688765.1 110805245 4209748 1310154..1311785 1 NC_008258.1 Code: E; COG: COG4166; periplasmic oligopeptide binding protein 1311785 oppA 4209748 oppA Shigella flexneri 5 str. 8401 periplasmic oligopeptide binding protein YP_688765.1 1310154 D 373384 CDS YP_688766.1 110805246 4209749 1311871..1312791 1 NC_008258.1 Code: EP; COG: COG0601; oligopeptide transporter permease 1312791 oppB 4209749 oppB Shigella flexneri 5 str. 8401 oligopeptide transporter permease YP_688766.1 1311871 D 373384 CDS YP_688767.1 110805247 4209750 1312806..1313714 1 NC_008258.1 Code: EP; COG: COG1173; oligopeptide transport permease 1313714 oppC 4209750 oppC Shigella flexneri 5 str. 8401 oligopeptide transport permease YP_688767.1 1312806 D 373384 CDS YP_688768.1 110805248 4209751 1313726..1314739 1 NC_008258.1 Code: EP; COG: COG0444; oligopeptide transporter ATP-binding protein 1314739 oppD 4209751 oppD Shigella flexneri 5 str. 8401 oligopeptide transporter ATP-binding protein YP_688768.1 1313726 D 373384 CDS YP_688769.1 110805249 4209752 1314736..1315740 1 NC_008258.1 Code: E; COG: COG4608; peptide ABC transporter ATP-binding protein 1315740 oppF 4209752 oppF Shigella flexneri 5 str. 8401 peptide ABC transporter ATP-binding protein YP_688769.1 1314736 D 373384 CDS YP_688770.1 110805250 4209753 complement(1315793..1316200) 1 NC_008258.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1316200 4209753 SFV_1260 Shigella flexneri 5 str. 8401 dsDNA-mimic protein YP_688770.1 1315793 R 373384 CDS YP_688771.1 110805251 4209754 complement(1316157..1317533) 1 NC_008258.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1317533 cls 4209754 cls Shigella flexneri 5 str. 8401 cardiolipin synthetase YP_688771.1 1316157 R 373384 CDS YP_688772.1 110805252 4209755 complement(1317988..1319241) 1 NC_008258.1 Code: P; COG: COG1226; voltage-gated potassium channel 1319241 kch 4209755 kch Shigella flexneri 5 str. 8401 voltage-gated potassium channel YP_688772.1 1317988 R 373384 CDS YP_688773.1 110805253 4209756 1319604..1319906 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1319906 4209756 SFV_1263 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688773.1 1319604 D 373384 CDS YP_688774.1 110805254 4209757 1320047..1320760 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1320760 4209757 SFV_1264 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688774.1 1320047 D 373384 CDS YP_688775.2 162139345 4209758 complement(1320808..1321104) 1 NC_008258.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein 1321104 yciI 4209758 yciI Shigella flexneri 5 str. 8401 hypothetical protein YP_688775.2 1320808 R 373384 CDS YP_688776.1 110805256 4209759 1321277..1322059 1 NC_008258.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transport protein TonB 1322059 tonB 4209759 tonB Shigella flexneri 5 str. 8401 transport protein TonB YP_688776.1 1321277 D 373384 CDS YP_688777.1 110805257 4209760 complement(1322099..1322497) 1 NC_008258.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins; acyl-CoA thioester hydrolase 1322497 yciA 4209760 yciA Shigella flexneri 5 str. 8401 acyl-CoA thioester hydrolase YP_688777.1 1322099 R 373384 CDS YP_688778.1 110805258 4209761 complement(1322602..1323141) 1 NC_008258.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1323141 yciB 4209761 yciB Shigella flexneri 5 str. 8401 intracellular septation protein A YP_688778.1 1322602 R 373384 CDS YP_688779.1 110805259 4209762 complement(1323171..1323914) 1 NC_008258.1 hypothetical protein 1323914 yciC 4209762 yciC Shigella flexneri 5 str. 8401 hypothetical protein YP_688779.1 1323171 R 373384 CDS YP_688780.1 110805260 4209763 1324271..1324909 1 NC_008258.1 receptor for colicin S4; outer membrane protein W 1324909 yciD 4209763 yciD Shigella flexneri 5 str. 8401 outer membrane protein W YP_688780.1 1324271 D 373384 CDS YP_688781.1 110805261 4209764 complement(1324969..1325475) 1 NC_008258.1 Code: S; COG: COG3685; hypothetical protein 1325475 yciE 4209764 yciE Shigella flexneri 5 str. 8401 hypothetical protein YP_688781.1 1324969 R 373384 CDS YP_688782.1 110805262 4209765 complement(1325521..1326021) 1 NC_008258.1 Code: S; COG: COG3685; structural protein 1326021 yciF 4209765 yciF Shigella flexneri 5 str. 8401 structural protein YP_688782.1 1325521 R 373384 CDS YP_688783.1 110805263 4207043 complement(1326107..1326343) 1 NC_008258.1 Code: R; COG: COG3729; hypothetical protein 1326343 yciG 4207043 yciG Shigella flexneri 5 str. 8401 hypothetical protein YP_688783.1 1326107 R 373384 CDS YP_688784.1 110805264 4207044 complement(1326667..1327473) 1 NC_008258.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1327473 trpA 4207044 trpA Shigella flexneri 5 str. 8401 tryptophan synthase subunit alpha YP_688784.1 1326667 R 373384 CDS YP_688785.1 110805265 4207045 complement(1327473..1328666) 1 NC_008258.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1328666 trpB 4207045 trpB Shigella flexneri 5 str. 8401 tryptophan synthase subunit beta YP_688785.1 1327473 R 373384 CDS YP_688786.1 110805266 4207046 complement(1328678..1330039) 1 NC_008258.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1330039 trpC 4207046 trpC Shigella flexneri 5 str. 8401 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_688786.1 1328678 R 373384 CDS YP_688787.1 110805267 4207047 complement(1330040..1331635) 1 NC_008258.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1331635 trpD 4207047 trpD Shigella flexneri 5 str. 8401 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_688787.1 1330040 R 373384 CDS YP_688788.1 110805268 4207048 complement(1331635..1333197) 1 NC_008258.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1333197 trpE 4207048 trpE Shigella flexneri 5 str. 8401 anthranilate synthase component I YP_688788.1 1331635 R 373384 CDS YP_688789.1 110805269 4207049 1333492..1334352 1 NC_008258.1 Code: R; COG: COG0613; hypothetical protein 1334352 yciV 4207049 yciV Shigella flexneri 5 str. 8401 hypothetical protein YP_688789.1 1333492 D 373384 CDS YP_688790.1 110805270 4207050 1334313..1334969 1 NC_008258.1 Code: J; COG: COG0009; hypothetical protein 1334969 yciO 4207050 yciO Shigella flexneri 5 str. 8401 hypothetical protein YP_688790.1 1334313 D 373384 CDS YP_688791.1 110805271 4207051 1335070..1335942 1 NC_008258.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1335942 yciL 4207051 yciL Shigella flexneri 5 str. 8401 23S rRNA pseudouridylate synthase B YP_688791.1 1335070 D 373384 CDS YP_688792.1 110805272 4207052 complement(1335982..1336572) 1 NC_008258.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1336572 btuR 4207052 btuR Shigella flexneri 5 str. 8401 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_688792.1 1335982 R 373384 CDS YP_688793.1 110805273 4207053 complement(1336569..1337327) 1 NC_008258.1 Code: IQR; COG: COG1028; short chain dehydrogenase 1337327 yciK 4207053 yciK Shigella flexneri 5 str. 8401 short chain dehydrogenase YP_688793.1 1336569 R 373384 CDS YP_688794.1 110805274 4207054 1337706..1338596 1 NC_008258.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1338596 sohB 4207054 sohB Shigella flexneri 5 str. 8401 periplasmic protease YP_688794.1 1337706 D 373384 CDS YP_688795.1 110805275 4207055 1339221..1341860 1 NC_008258.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1341860 topA 4207055 topA Shigella flexneri 5 str. 8401 DNA topoisomerase I YP_688795.1 1339221 D 373384 CDS YP_688796.1 110805276 4207056 1342070..1343044 1 NC_008258.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1343044 cysB 4207056 cysB Shigella flexneri 5 str. 8401 transcriptional regulator CysB YP_688796.1 1342070 D 373384 CDS YP_688797.1 110805277 4207057 1343339..1343503 1 NC_008258.1 hypothetical protein 1343503 4207057 SFV_1287 Shigella flexneri 5 str. 8401 hypothetical protein YP_688797.1 1343339 D 373384 CDS YP_688798.1 110805278 4207058 1343507..1343674 1 NC_008258.1 hypothetical protein 1343674 4207058 SFV_1288 Shigella flexneri 5 str. 8401 hypothetical protein YP_688798.1 1343507 D 373384 CDS YP_688799.1 110805279 4207059 1344047..1346722 1 NC_008258.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1346722 acnA 4207059 acnA Shigella flexneri 5 str. 8401 aconitate hydratase YP_688799.1 1344047 D 373384 CDS YP_688800.1 110805280 4207060 complement(1346786..1347376) 1 NC_008258.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1347376 ribA 4207060 ribA Shigella flexneri 5 str. 8401 GTP cyclohydrolase II YP_688800.1 1346786 R 373384 CDS YP_688801.1 110805281 4207061 1347546..1348310 1 NC_008258.1 Code: I; COG: COG0671; phosphatidylglycerophosphatase B 1348310 pgpB 4207061 pgpB Shigella flexneri 5 str. 8401 phosphatidylglycerophosphatase B YP_688801.1 1347546 D 373384 CDS YP_688802.1 110805282 4207062 1348459..1348767 1 NC_008258.1 Code: S; COG: COG3771; hypothetical protein 1348767 yciS 4207062 yciS Shigella flexneri 5 str. 8401 hypothetical protein YP_688802.1 1348459 D 373384 CDS YP_688803.1 110805283 4210729 1348828..1349943 1 NC_008258.1 Code: G; COG: COG2956; tetratricopeptide repeat-containing protein 1349943 yciM 4210729 yciM Shigella flexneri 5 str. 8401 tetratricopeptide repeat-containing protein YP_688803.1 1348828 D 373384 CDS YP_688804.1 110805284 4210730 1350136..1350873 1 NC_008258.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1350873 pyrF 4210730 pyrF Shigella flexneri 5 str. 8401 orotidine 5'-phosphate decarboxylase YP_688804.1 1350136 D 373384 CDS YP_688805.1 110805285 4210731 1350873..1351199 1 NC_008258.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1351199 yciH 4210731 yciH Shigella flexneri 5 str. 8401 translation initiation factor Sui1 YP_688805.1 1350873 D 373384 CDS YP_688806.1 110805286 4210732 complement(1351325..1351543) 1 NC_008258.1 lipoprotein 1351543 osmB 4210732 osmB Shigella flexneri 5 str. 8401 lipoprotein YP_688806.1 1351325 R 373384 CDS YP_688807.1 110805287 4210733 complement(1351812..1352561) 1 NC_008258.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 1352561 4210733 SFV_1297 Shigella flexneri 5 str. 8401 DeoR-type transcriptional regulator YP_688807.1 1351812 R 373384 CDS YP_688808.1 110805288 4210734 complement(1352651..1352824) 1 NC_008258.1 hypothetical protein 1352824 4210734 SFV_1298 Shigella flexneri 5 str. 8401 hypothetical protein YP_688808.1 1352651 R 373384 CDS YP_688809.1 110805289 4210736 complement(1355180..1357114) 1 NC_008258.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1357114 rnb 4210736 rnb Shigella flexneri 5 str. 8401 exoribonuclease II YP_688809.1 1355180 R 373384 CDS YP_688810.1 110805290 4210737 complement(1357182..1358309) 1 NC_008258.1 oxidoreductase 1358309 yciW 4210737 yciW Shigella flexneri 5 str. 8401 oxidoreductase YP_688810.1 1357182 R 373384 CDS YP_688811.1 110805291 4210738 complement(1358453..1359241) 1 NC_008258.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1359241 fabI 4210738 fabI Shigella flexneri 5 str. 8401 enoyl-ACP reductase YP_688811.1 1358453 R 373384 CDS YP_688812.1 110805292 4210739 complement(1359609..1359959) 1 NC_008258.1 Code: S; COG: COG2852; hypothetical protein 1359959 ycjD 4210739 ycjD Shigella flexneri 5 str. 8401 hypothetical protein YP_688812.1 1359609 R 373384 CDS YP_688813.1 110805293 4210740 complement(1360030..1360836) 1 NC_008258.1 Code: V; COG: COG4167; peptide ABC transporter ATP-binding protein 1360836 sapF 4210740 sapF Shigella flexneri 5 str. 8401 peptide ABC transporter ATP-binding protein YP_688813.1 1360030 R 373384 CDS YP_688814.1 110805294 4210741 complement(1360838..1361830) 1 NC_008258.1 Code: V; COG: COG4170; peptide ABC transporter ATP-binding protein 1361830 sapD 4210741 sapD Shigella flexneri 5 str. 8401 peptide ABC transporter ATP-binding protein YP_688814.1 1360838 R 373384 CDS YP_688815.1 110805295 4210742 complement(1361830..1362720) 1 NC_008258.1 Code: V; COG: COG4171; peptide transport permease 1362720 sapC 4210742 sapC Shigella flexneri 5 str. 8401 peptide transport permease YP_688815.1 1361830 R 373384 CDS YP_688816.1 110805296 4210743 complement(1362707..1363672) 1 NC_008258.1 Code: V; COG: COG4168; peptide transport permease 1363672 sapB 4210743 sapB Shigella flexneri 5 str. 8401 peptide transport permease YP_688816.1 1362707 R 373384 CDS YP_688817.1 110805297 4210744 complement(1363669..1365312) 1 NC_008258.1 Code: E; COG: COG4166; peptide transport periplasmic protein 1365312 sapA 4210744 sapA Shigella flexneri 5 str. 8401 peptide transport periplasmic protein YP_688817.1 1363669 R 373384 CDS YP_688818.1 110805298 4210745 complement(1365625..1365870) 1 NC_008258.1 hypothetical protein 1365870 ymjA 4210745 ymjA Shigella flexneri 5 str. 8401 hypothetical protein YP_688818.1 1365625 R 373384 CDS YP_688819.1 110805299 4210746 complement(1366004..1367389) 1 NC_008258.1 Code: E; COG: COG0531; amino acid/amine transport protein 1367389 ycjJ 4210746 ycjJ Shigella flexneri 5 str. 8401 amino acid/amine transport protein YP_688819.1 1366004 R 373384 CDS YP_688820.1 110805300 4210747 complement(1367692..1369110) 1 NC_008258.1 Code: E; COG: COG0174; glutamine synthetase 1369110 4210747 SFV_1311 Shigella flexneri 5 str. 8401 glutamine synthetase YP_688820.1 1367692 R 373384 CDS YP_688821.1 110805301 4209347 1369449..1370087 1 NC_008258.1 Code: R; COG: COG2071; gamma-glutamyl-gamma-aminobutyrate hydrolase 1370087 ycjL 4209347 ycjL Shigella flexneri 5 str. 8401 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_688821.1 1369449 D 373384 CDS YP_688822.1 110805302 4209348 1370284..1370670 1 NC_008258.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1370670 ycjC 4209348 ycjC Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor PuuR YP_688822.1 1370284 D 373384 CDS YP_688823.1 110805303 4209349 1370820..1372307 1 NC_008258.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1372307 aldH 4209349 aldH Shigella flexneri 5 str. 8401 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase YP_688823.1 1370820 D 373384 CDS YP_688824.1 110805304 4209350 1372309..1373589 1 NC_008258.1 Code: E; COG: COG0665; oxidoreductase 1373589 ordL 4209350 ordL Shigella flexneri 5 str. 8401 oxidoreductase YP_688824.1 1372309 D 373384 CDS YP_688825.1 110805305 4209351 1373627..1374892 1 NC_008258.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 1374892 goaG 4209351 goaG Shigella flexneri 5 str. 8401 4-aminobutyrate aminotransferase YP_688825.1 1373627 D 373384 CDS YP_688826.1 110805306 4209352 complement(1375012..1375989) 1 NC_008258.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1375989 pspF 4209352 pspF Shigella flexneri 5 str. 8401 phage shock protein operon transcriptional activator YP_688826.1 1375012 R 373384 CDS YP_688827.1 110805307 4209353 1376156..1376824 1 NC_008258.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1376824 pspA 4209353 pspA Shigella flexneri 5 str. 8401 phage shock protein PspA YP_688827.1 1376156 D 373384 CDS YP_688828.1 110805308 4209354 1376878..1377102 1 NC_008258.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1377102 pspB 4209354 pspB Shigella flexneri 5 str. 8401 phage shock protein B YP_688828.1 1376878 D 373384 CDS YP_688829.1 110805309 4209355 1377102..1377461 1 NC_008258.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1377461 pspC 4209355 pspC Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator PspC YP_688829.1 1377102 D 373384 CDS YP_688830.1 110805310 4209356 1377458..1377691 1 NC_008258.1 peripheral inner membrane phage-shock protein 1377691 pspD 4209356 pspD Shigella flexneri 5 str. 8401 peripheral inner membrane phage-shock protein YP_688830.1 1377458 D 373384 CDS YP_688831.1 110805311 4209357 1377734..1378081 1 NC_008258.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1378081 pspE 4209357 pspE Shigella flexneri 5 str. 8401 thiosulfate:cyanide sulfurtransferase YP_688831.1 1377734 D 373384 CDS YP_688832.1 110805312 4209359 1379646..1380149 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1380149 insB 4209359 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688832.1 1379646 D 373384 CDS YP_688833.1 110805313 4209361 1382067..1382948 1 NC_008258.1 Code: G; COG: COG1175; binding-protein dependent transport protein 1382948 ycjO 4209361 ycjO Shigella flexneri 5 str. 8401 binding-protein dependent transport protein YP_688833.1 1382067 D 373384 CDS YP_688834.1 110805314 4209362 1382935..1383777 1 NC_008258.1 Code: G; COG: COG0395; transport system permease 1383777 ycjP 4209362 ycjP Shigella flexneri 5 str. 8401 transport system permease YP_688834.1 1382935 D 373384 CDS YP_688835.1 110805315 4209363 1383808..1384860 1 NC_008258.1 Code: ER; COG: COG1063; oxidoreductase 1384860 ycjQ 4209363 ycjQ Shigella flexneri 5 str. 8401 oxidoreductase YP_688835.1 1383808 D 373384 CDS YP_688836.1 110805316 4209366 1386714..1388981 1 NC_008258.1 Code: G; COG: COG1554; hypothetical protein 1388981 ycjT 4209366 ycjT Shigella flexneri 5 str. 8401 hypothetical protein YP_688836.1 1386714 D 373384 CDS YP_688837.1 110805317 4209522 1388978..1389637 1 NC_008258.1 Code: R; COG: COG0637; beta-phosphoglucomutase 1389637 ycjU 4209522 ycjU Shigella flexneri 5 str. 8401 beta-phosphoglucomutase YP_688837.1 1388978 D 373384 CDS YP_688838.1 110805318 4209523 1389651..1390619 1 NC_008258.1 Code: G; COG: COG3839; ABC transporter ATP-binding protein 1390619 ycjV 4209523 ycjV Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_688838.1 1389651 D 373384 CDS YP_688839.1 110805319 4209525 complement(1391788..1392786) 1 NC_008258.1 Code: K; COG: COG1609; LACI-type transcriptional regulator 1392786 ycjW 4209525 ycjW Shigella flexneri 5 str. 8401 LACI-type transcriptional regulator YP_688839.1 1391788 R 373384 CDS YP_688840.1 110805320 4209526 1392942..1394339 1 NC_008258.1 Code: R; COG: COG3106; hypothetical protein 1394339 ycjX 4209526 ycjX Shigella flexneri 5 str. 8401 hypothetical protein YP_688840.1 1392942 D 373384 CDS YP_688841.1 110805321 4209527 1394336..1395397 1 NC_008258.1 Code: S; COG: COG3768; hypothetical protein 1395397 ycjF 4209527 ycjF Shigella flexneri 5 str. 8401 hypothetical protein YP_688841.1 1394336 D 373384 CDS YP_688842.1 110805322 4209528 1395545..1397086 1 NC_008258.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1397086 tyrR 4209528 tyrR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator TyrR YP_688842.1 1395545 D 373384 CDS YP_688843.1 110805323 4209529 complement(1397130..1397636) 1 NC_008258.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1397636 tpx 4209529 tpx Shigella flexneri 5 str. 8401 thiol peroxidase YP_688843.1 1397130 R 373384 CDS YP_688844.1 110805324 4209530 1397755..1398720 1 NC_008258.1 Code: MR; COG: COG4948; muconate cycloisomerase I 1398720 ycjG 4209530 ycjG Shigella flexneri 5 str. 8401 muconate cycloisomerase I YP_688844.1 1397755 D 373384 CDS YP_688845.1 110805325 4209531 complement(1398695..1399483) 1 NC_008258.1 Code: E; COG: COG2866; murein peptide amidase A 1399483 ycjI 4209531 ycjI Shigella flexneri 5 str. 8401 murein peptide amidase A YP_688845.1 1398695 R 373384 CDS YP_688846.1 110805326 4209532 complement(1399714..1400352) 1 NC_008258.1 Code: MG; COG: COG0702; hypothetical protein 1400352 4209532 SFV_1343 Shigella flexneri 5 str. 8401 hypothetical protein YP_688846.1 1399714 R 373384 CDS YP_688847.1 110805327 4209533 complement(1400370..1400900) 1 NC_008258.1 Code: R; COG: COG1073; hypothetical protein 1400900 4209533 SFV_1344 Shigella flexneri 5 str. 8401 hypothetical protein YP_688847.1 1400370 R 373384 CDS YP_688848.1 110805328 4209534 1401180..1402376 1 NC_008258.1 Code: L; COG: COG3547; ISSfl2 ORF 1402376 4209534 SFV_1345 Shigella flexneri 5 str. 8401 ISSfl2 ORF YP_688848.1 1401180 D 373384 CDS YP_688849.1 110805329 4209535 complement(1402390..1402752) 1 NC_008258.1 Code: R; COG: COG1073; hypothetical protein 1402752 4209535 SFV_1346 Shigella flexneri 5 str. 8401 hypothetical protein YP_688849.1 1402390 R 373384 CDS YP_688850.1 110805330 4209536 complement(1402752..1403669) 1 NC_008258.1 Code: R; COG: COG1073; hypothetical protein 1403669 4209536 SFV_1347 Shigella flexneri 5 str. 8401 hypothetical protein YP_688850.1 1402752 R 373384 CDS YP_688851.1 110805331 4209537 complement(1404289..1405002) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1405002 4209537 SFV_1348 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688851.1 1404289 R 373384 CDS YP_688852.1 110805332 4209538 complement(1405143..1405445) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1405445 4209538 SFV_1349 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688852.1 1405143 R 373384 CDS YP_688853.1 110805333 4209539 1405782..1406120 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 1406120 4209539 SFV_1350 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_688853.1 1405782 D 373384 CDS YP_688854.1 110805334 4209540 1406421..1406987 1 NC_008258.1 IS911 ORF2 1406987 4209540 SFV_1351 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_688854.1 1406421 D 373384 CDS YP_688855.2 162139344 4209600 complement(1407226..1408131) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1408131 4209600 SFV_1352 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_688855.2 1407226 R 373384 CDS YP_688856.1 110805336 4209601 complement(1408089..1408499) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1408499 4209601 SFV_1353 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_688856.1 1408089 R 373384 CDS YP_688857.1 110805337 4209602 1408711..1409286 1 NC_008258.1 bacteriophage protein 1409286 4209602 SFV_1354 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688857.1 1408711 D 373384 CDS YP_688858.1 110805338 4209603 1409293..1410039 1 NC_008258.1 Code: L; COG: COG1484; replication protein 1410039 4209603 SFV_1355 Shigella flexneri 5 str. 8401 replication protein YP_688858.1 1409293 D 373384 CDS YP_688859.1 110805339 4209604 1410534..1410890 1 NC_008258.1 bacteriophage protein 1410890 4209604 SFV_1356 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688859.1 1410534 D 373384 CDS YP_688860.1 110805340 4209605 1410983..1411201 1 NC_008258.1 hypothetical protein 1411201 4209605 SFV_1357 Shigella flexneri 5 str. 8401 hypothetical protein YP_688860.1 1410983 D 373384 CDS YP_688861.1 110805341 4209606 1411565..1412230 1 NC_008258.1 hypothetical protein 1412230 4209606 SFV_1358 Shigella flexneri 5 str. 8401 hypothetical protein YP_688861.1 1411565 D 373384 CDS YP_688862.1 110805342 4209607 1412230..1412664 1 NC_008258.1 bacteriophage protein 1412664 4209607 SFV_1359 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688862.1 1412230 D 373384 CDS YP_688863.1 110805343 4209608 complement(1413700..1414203) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1414203 insB 4209608 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688863.1 1413700 R 373384 CDS YP_688864.1 110805344 4209609 1414531..1415130 1 NC_008258.1 prophage protein 1415130 4209609 SFV_1361 Shigella flexneri 5 str. 8401 prophage protein YP_688864.1 1414531 D 373384 CDS YP_688865.1 110805345 4209610 1415130..1415420 1 NC_008258.1 bacteriophage protein 1415420 4209610 SFV_1362 Shigella flexneri 5 str. 8401 bacteriophage protein YP_688865.1 1415130 D 373384 CDS YP_688866.1 110805346 4209611 1415417..1415971 1 NC_008258.1 hypothetical protein 1415971 4209611 SFV_1363 Shigella flexneri 5 str. 8401 hypothetical protein YP_688866.1 1415417 D 373384 CDS YP_688867.1 110805347 4209635 1416586..1418190 1 NC_008258.1 integrase 1418190 4209635 SFV_1368 Shigella flexneri 5 str. 8401 integrase YP_688867.1 1416586 D 373384 CDS YP_688868.1 110805348 4209636 complement(1419333..1419515) 1 NC_008258.1 IS1 encoded protein 1419515 4209636 SFV_1369 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688868.1 1419333 R 373384 CDS YP_688869.1 110805349 4209637 1419590..1420093 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1420093 insB 4209637 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688869.1 1419590 D 373384 CDS YP_688870.1 110805350 4209638 1420301..1421014 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1421014 4209638 SFV_1371 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688870.1 1420301 D 373384 CDS YP_688871.1 110805351 4209639 1421042..1421410 1 NC_008258.1 IS1 encoded protein 1421410 4209639 SFV_1372 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688871.1 1421042 D 373384 CDS YP_688872.1 110805352 4209640 1421607..1421978 1 NC_008258.1 tail fiber assembly protein 1421978 4209640 SFV_1373 Shigella flexneri 5 str. 8401 tail fiber assembly protein YP_688872.1 1421607 D 373384 CDS YP_688873.1 110805353 4209641 1422002..1423270 1 NC_008258.1 tail fiber protein 1423270 4209641 SFV_1374 Shigella flexneri 5 str. 8401 tail fiber protein YP_688873.1 1422002 D 373384 CDS YP_688874.1 110805354 4209642 1423221..1423844 1 NC_008258.1 hypothetical protein 1423844 4209642 SFV_1375 Shigella flexneri 5 str. 8401 hypothetical protein YP_688874.1 1423221 D 373384 CDS YP_688875.1 110805355 4209643 complement(1424045..1424902) 1 NC_008258.1 Code: P; COG: COG1108; Iron transport protein, inner membrane component 1424902 sitD 4209643 sitD Shigella flexneri 5 str. 8401 Iron transport protein, inner membrane component YP_688875.1 1424045 R 373384 CDS YP_688876.1 110805356 4209644 complement(1424899..1425582) 1 NC_008258.1 Code: P; COG: COG1108; Iron transport protein 1425582 sitC 4209644 sitC Shigella flexneri 5 str. 8401 Iron transport protein YP_688876.1 1424899 R 373384 CDS YP_688877.1 110805357 4209645 complement(1425753..1426580) 1 NC_008258.1 Code: P; COG: COG1121; iron ABC transporter ATP-binding protein 1426580 sitB 4209645 sitB Shigella flexneri 5 str. 8401 iron ABC transporter ATP-binding protein YP_688877.1 1425753 R 373384 CDS YP_688878.1 110805358 4209646 complement(1426580..1427494) 1 NC_008258.1 Code: P; COG: COG0803; Iron transport protein 1427494 sitA 4209646 sitA Shigella flexneri 5 str. 8401 Iron transport protein YP_688878.1 1426580 R 373384 CDS YP_688879.1 110805359 4209647 complement(1427945..1428550) 1 NC_008258.1 integrase for prophage 1428550 4209647 SFV_1380 Shigella flexneri 5 str. 8401 integrase for prophage YP_688879.1 1427945 R 373384 CDS YP_688880.1 110805360 4209648 complement(1428550..1428759) 1 NC_008258.1 IS1 encoded protein 1428759 4209648 SFV_1381 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688880.1 1428550 R 373384 CDS YP_688881.1 110805361 4209649 1428834..1429337 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1429337 insB 4209649 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688881.1 1428834 D 373384 CDS YP_688882.1 110805362 4209650 1429728..1430402 1 NC_008258.1 ISSfl4 ORF1 1430402 4209650 SFV_1383 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_688882.1 1429728 D 373384 CDS YP_688883.1 110805363 4209651 1430399..1430746 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 1430746 4209651 SFV_1384 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_688883.1 1430399 D 373384 CDS YP_688884.1 110805364 4209652 1430766..1432367 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF3 1432367 4209652 SFV_1385 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_688884.1 1430766 D 373384 CDS YP_688885.1 110805365 4209653 1432626..1433249 1 NC_008258.1 tail component of prophage 1433249 4209653 SFV_1386 Shigella flexneri 5 str. 8401 tail component of prophage YP_688885.1 1432626 D 373384 CDS YP_688886.1 110805366 4207870 complement(1433429..1435084) 1 NC_008258.1 Code: S; COG: COG4886; invasion plasmid antigen 1435084 ipaH_2 4207870 ipaH_2 Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_688886.1 1433429 R 373384 CDS YP_688887.1 110805367 4207872 1436336..1436638 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1436638 4207872 SFV_1389 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688887.1 1436336 D 373384 CDS YP_688888.1 110805368 4207873 1436779..1437492 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1437492 4207873 SFV_1390 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688888.1 1436779 D 373384 CDS YP_688889.1 110805369 4207874 complement(1437749..1438024) 1 NC_008258.1 hypothetical protein 1438024 4207874 SFV_1391 Shigella flexneri 5 str. 8401 hypothetical protein YP_688889.1 1437749 R 373384 CDS YP_688890.1 110805370 4207875 complement(1438045..1438281) 1 NC_008258.1 hypothetical protein 1438281 4207875 SFV_1392 Shigella flexneri 5 str. 8401 hypothetical protein YP_688890.1 1438045 R 373384 CDS YP_688891.1 110805371 4207876 complement(1438399..1439844) 1 NC_008258.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 1439844 yebU 4207876 yebU Shigella flexneri 5 str. 8401 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_688891.1 1438399 R 373384 CDS YP_688892.1 110805372 4207877 complement(1439918..1441840) 1 NC_008258.1 Code: R; COG: COG3008; hypothetical protein 1441840 4207877 SFV_1394 Shigella flexneri 5 str. 8401 hypothetical protein YP_688892.1 1439918 R 373384 CDS YP_688893.1 110805373 4207878 complement(1441886..1442557) 1 NC_008258.1 paraquat-inducible protein 1442557 4207878 SFV_1395 Shigella flexneri 5 str. 8401 paraquat-inducible protein YP_688893.1 1441886 R 373384 CDS YP_688894.1 110805374 4207879 complement(1442520..1443803) 1 NC_008258.1 Code: S; COG: COG2995; hypothetical protein 1443803 4207879 SFV_1396 Shigella flexneri 5 str. 8401 hypothetical protein YP_688894.1 1442520 R 373384 CDS YP_688895.1 110805375 4207880 1443933..1444430 1 NC_008258.1 Code: T; COG: COG1956; hypothetical protein 1444430 4207880 SFV_1397 Shigella flexneri 5 str. 8401 hypothetical protein YP_688895.1 1443933 D 373384 CDS YP_688896.1 110805376 4207881 1444527..1445225 1 NC_008258.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 1445225 proQ 4207881 proQ Shigella flexneri 5 str. 8401 solute/DNA competence effector YP_688896.1 1444527 D 373384 CDS YP_688897.1 110805377 4207882 1445245..1447293 1 NC_008258.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 1447293 prc 4207882 prc Shigella flexneri 5 str. 8401 carboxy-terminal protease YP_688897.1 1445245 D 373384 CDS YP_688898.1 110805378 4207883 1447485..1448366 1 NC_008258.1 metalloprotease; heat shock protein HtpX 1448366 htpX 4207883 htpX Shigella flexneri 5 str. 8401 heat shock protein HtpX YP_688898.1 1447485 D 373384 CDS YP_688899.1 110805379 4207884 complement(1448412..1449896) 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 1449896 4207884 SFV_1401 Shigella flexneri 5 str. 8401 transport protein YP_688899.1 1448412 R 373384 CDS YP_688900.1 110805380 4207885 1449962..1450753 1 NC_008258.1 Code: K; COG: COG1414; regulator 1450753 4207885 SFV_1402 Shigella flexneri 5 str. 8401 regulator YP_688900.1 1449962 D 373384 CDS YP_688901.1 110805381 4207886 1451294..1451437 1 NC_008258.1 hypothetical protein 1451437 4207886 SFV_1403 Shigella flexneri 5 str. 8401 hypothetical protein YP_688901.1 1451294 D 373384 CDS YP_688902.1 110805382 4207887 1451512..1451799 1 NC_008258.1 hypothetical protein 1451799 4207887 SFV_1404 Shigella flexneri 5 str. 8401 hypothetical protein YP_688902.1 1451512 D 373384 CDS YP_688903.1 110805383 4207888 1452625..1452834 1 NC_008258.1 Code: K; COG: COG1278; cold shock-like protein CspC 1452834 cspC 4207888 cspC Shigella flexneri 5 str. 8401 cold shock-like protein CspC YP_688903.1 1452625 D 373384 CDS YP_688904.1 110805384 4209483 1453000..1453809 1 NC_008258.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase 1453809 rrmA 4209483 rrmA Shigella flexneri 5 str. 8401 23S rRNA methyltransferase YP_688904.1 1453000 D 373384 CDS YP_688905.1 110805385 4209484 complement(1453806..1454615) 1 NC_008258.1 Code: S; COG: COG1971; hypothetical protein 1454615 4209484 SFV_1407 Shigella flexneri 5 str. 8401 hypothetical protein YP_688905.1 1453806 R 373384 CDS YP_688906.1 110805386 4209485 complement(1454835..1455338) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1455338 insB 4209485 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688906.1 1454835 R 373384 CDS YP_688907.1 110805387 4209486 complement(1455561..1456037) 1 NC_008258.1 Code: S; COG: COG4811; hypothetical protein 1456037 4209486 SFV_1409 Shigella flexneri 5 str. 8401 hypothetical protein YP_688907.1 1455561 R 373384 CDS YP_688908.1 110805388 4209487 complement(1456092..1456943) 1 NC_008258.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1456943 manZ 4209487 manZ Shigella flexneri 5 str. 8401 PTS system mannose-specific transporter subunit IID YP_688908.1 1456092 R 373384 CDS YP_688909.1 110805389 4209488 complement(1456956..1457756) 1 NC_008258.1 Code: G; COG: COG3715; PTS enzyme IIC, mannose-specific 1457756 manY 4209488 manY Shigella flexneri 5 str. 8401 PTS enzyme IIC, mannose-specific YP_688909.1 1456956 R 373384 CDS YP_688910.1 110805390 4209489 complement(1457819..1458790) 1 NC_008258.1 PTS enzyme IIAB 1458790 manX 4209489 manX Shigella flexneri 5 str. 8401 PTS enzyme IIAB YP_688910.1 1457819 R 373384 CDS YP_688911.1 110805391 4209490 1459253..1460803 1 NC_008258.1 transport protein 1460803 yoaE 4209490 yoaE Shigella flexneri 5 str. 8401 transport protein YP_688911.1 1459253 D 373384 CDS YP_688912.1 110805392 4209491 complement(1460807..1462405) 1 NC_008258.1 hypothetical protein 1462405 4209491 SFV_1414 Shigella flexneri 5 str. 8401 hypothetical protein YP_688912.1 1460807 R 373384 CDS YP_688913.1 110805393 4209492 complement(1462536..1463882) 1 NC_008258.1 Code: E; COG: COG1760; L-serine deaminase 1463882 sdaA 4209492 sdaA Shigella flexneri 5 str. 8401 L-serine deaminase YP_688913.1 1462536 R 373384 CDS YP_688914.1 110805394 4209493 complement(1464084..1464662) 1 NC_008258.1 Code: LR; COG: COG0494; hypothetical protein 1464662 yeaB 4209493 yeaB Shigella flexneri 5 str. 8401 hypothetical protein YP_688914.1 1464084 R 373384 CDS YP_688915.1 110805395 4209494 complement(1464666..1466027) 1 NC_008258.1 Code: EH; COG: COG0147; para-aminobenzoate synthase component I 1466027 pabB 4209494 pabB Shigella flexneri 5 str. 8401 para-aminobenzoate synthase component I YP_688915.1 1464666 R 373384 CDS YP_688916.1 110805396 4209495 1466101..1466280 1 NC_008258.1 Code: S; COG: COG3140; hypothetical protein 1466280 4209495 SFV_1418 Shigella flexneri 5 str. 8401 hypothetical protein YP_688916.1 1466101 D 373384 CDS YP_688917.1 110805397 4209496 complement(1466400..1466759) 1 NC_008258.1 hypothetical protein 1466759 4209496 SFV_1419 Shigella flexneri 5 str. 8401 hypothetical protein YP_688917.1 1466400 R 373384 CDS YP_688918.1 110805398 4209497 complement(1467115..1467507) 1 NC_008258.1 Code: J; COG: COG0251; hypothetical protein 1467507 4209497 SFV_1420 Shigella flexneri 5 str. 8401 hypothetical protein YP_688918.1 1467115 R 373384 CDS YP_688919.1 110805399 4209498 1467591..1469501 1 NC_008258.1 Code: KL; COG: COG1199; hypothetical protein 1469501 4209498 SFV_1421 Shigella flexneri 5 str. 8401 hypothetical protein YP_688919.1 1467591 D 373384 CDS YP_688920.1 110805400 4209499 1469559..1470254 1 NC_008258.1 Code: O; COG: COG1214; hypothetical protein 1470254 yeaZ 4209499 yeaZ Shigella flexneri 5 str. 8401 hypothetical protein YP_688920.1 1469559 D 373384 CDS YP_688921.1 110805401 4209500 1470294..1470875 1 NC_008258.1 Code: M; COG: COG3065; outer membrane protein 1470875 4209500 SFV_1423 Shigella flexneri 5 str. 8401 outer membrane protein YP_688921.1 1470294 D 373384 CDS YP_688922.1 110805402 4209501 1471047..1472765 1 NC_008258.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1472765 fadD 4209501 fadD Shigella flexneri 5 str. 8401 long-chain-fatty-acid--CoA ligase YP_688922.1 1471047 D 373384 CDS YP_688923.1 110805403 4209502 1472835..1473962 1 NC_008258.1 Code: J; COG: COG0349; ribonuclease D 1473962 rnd 4209502 rnd Shigella flexneri 5 str. 8401 ribonuclease D YP_688923.1 1472835 D 373384 CDS YP_688924.1 110805404 4207381 complement(1474016..1474981) 1 NC_008258.1 Code: C; COG: COG1018; diogenase subunit beta 1474981 yeaX 4207381 yeaX Shigella flexneri 5 str. 8401 diogenase subunit beta YP_688924.1 1474016 R 373384 CDS YP_688925.1 110805405 4207382 complement(1475037..1475630) 1 NC_008258.1 dioxygenase subunit alpha 1475630 4207382 SFV_1427 Shigella flexneri 5 str. 8401 dioxygenase subunit alpha YP_688925.1 1475037 R 373384 CDS YP_688926.1 110805406 4207383 1475669..1475971 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1475971 4207383 SFV_1428 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_688926.1 1475669 D 373384 CDS YP_688927.1 110805407 4207384 1476112..1476825 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1476825 4207384 SFV_1429 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_688927.1 1476112 D 373384 CDS YP_688928.1 110805408 4207385 complement(1476822..1477217) 1 NC_008258.1 hypothetical protein 1477217 4207385 SFV_1430 Shigella flexneri 5 str. 8401 hypothetical protein YP_688928.1 1476822 R 373384 CDS YP_688929.1 110805409 4207386 complement(1477489..1477668) 1 NC_008258.1 IS1 encoded protein 1477668 4207386 SFV_1431 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688929.1 1477489 R 373384 CDS YP_688930.1 110805410 4207387 1477743..1478246 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1478246 insB 4207387 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688930.1 1477743 D 373384 CDS YP_688931.1 110805411 4207388 1478670..1479416 1 NC_008258.1 Code: M; COG: COG3713; hypothetical protein 1479416 yeaF 4207388 yeaF Shigella flexneri 5 str. 8401 hypothetical protein YP_688931.1 1478670 D 373384 CDS YP_688932.1 110805412 4207389 1479506..1480267 1 NC_008258.1 Code: R; COG: COG0656; aldehyde reductase 1480267 4207389 SFV_1434 Shigella flexneri 5 str. 8401 aldehyde reductase YP_688932.1 1479506 D 373384 CDS YP_688933.1 110805413 4207390 complement(1480318..1481202) 1 NC_008258.1 Code: G; COG: COG0676; hypothetical protein 1481202 yeaD 4207390 yeaD Shigella flexneri 5 str. 8401 hypothetical protein YP_688933.1 1480318 R 373384 CDS YP_688934.1 110805414 4207391 complement(1481286..1482281) 1 NC_008258.1 Code: G; COG: COG0057; glyceraldehyde-3-phosphate dehydrogenase 1482281 gapA 4207391 gapA Shigella flexneri 5 str. 8401 glyceraldehyde-3-phosphate dehydrogenase YP_688934.1 1481286 R 373384 CDS YP_688935.1 110805415 4207392 1482624..1483037 1 NC_008258.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 1483037 yeaA 4207392 yeaA Shigella flexneri 5 str. 8401 methionine sulfoxide reductase B YP_688935.1 1482624 D 373384 CDS YP_688936.1 110805416 4207393 1483034..1483351 1 NC_008258.1 Code: S; COG: COG3139; hypothetical protein 1483351 4207393 SFV_1438 Shigella flexneri 5 str. 8401 hypothetical protein YP_688936.1 1483034 D 373384 CDS YP_688937.1 110805417 4207394 1483721..1484797 1 NC_008258.1 Code: ER; COG: COG1063; oxidoreductase 1484797 4207394 SFV_1439 Shigella flexneri 5 str. 8401 oxidoreductase YP_688937.1 1483721 D 373384 CDS YP_688938.1 110805418 4207395 1484824..1486053 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 1486053 4207395 SFV_1440 Shigella flexneri 5 str. 8401 transport protein YP_688938.1 1484824 D 373384 CDS YP_688939.1 110805419 4207397 1487272..1488108 1 NC_008258.1 Code: G; COG: COG0191; aldolase 1488108 4207397 SFV_1442 Shigella flexneri 5 str. 8401 aldolase YP_688939.1 1487272 D 373384 CDS YP_688940.1 110805420 4207398 1488113..1489060 1 NC_008258.1 Code: G; COG: COG0524; kinase 1489060 4207398 SFV_1443 Shigella flexneri 5 str. 8401 kinase YP_688940.1 1488113 D 373384 CDS YP_688941.1 110805421 4207399 1489070..1490050 1 NC_008258.1 Code: C; COG: COG0667; hypothetical protein 1490050 4207399 SFV_1444 Shigella flexneri 5 str. 8401 hypothetical protein YP_688941.1 1489070 D 373384 CDS YP_688942.1 110805422 4207740 1490223..1490945 1 NC_008258.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 1490945 4207740 SFV_1445 Shigella flexneri 5 str. 8401 DeoR-type transcriptional regulator YP_688942.1 1490223 D 373384 CDS YP_688943.1 110805423 4207742 complement(1491826..1492017) 1 NC_008258.1 IS1 encoded protein 1492017 4207742 SFV_1447 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688943.1 1491826 R 373384 CDS YP_688944.1 110805424 4207743 1492092..1492595 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1492595 insB 4207743 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688944.1 1492092 D 373384 CDS YP_688945.1 110805425 4207744 complement(1493291..1493932) 1 NC_008258.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 1493932 ydjB 4207744 ydjB Shigella flexneri 5 str. 8401 nicotinamidase/pyrazinamidase YP_688945.1 1493291 R 373384 CDS YP_688946.1 110805426 4207745 complement(1493943..1494911) 1 NC_008258.1 converts asparagine to aspartate and ammonia; cytoplasmic asparaginase I 1494911 ansA 4207745 ansA Shigella flexneri 5 str. 8401 cytoplasmic asparaginase I YP_688946.1 1493943 R 373384 CDS YP_688947.1 110805427 4207746 complement(1495126..1496982) 1 NC_008258.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1496982 sppA 4207746 sppA Shigella flexneri 5 str. 8401 protease 4 YP_688947.1 1495126 R 373384 CDS YP_688948.1 110805428 4207747 1497161..1497694 1 NC_008258.1 Code: C; COG: COG0778; hypothetical protein 1497694 ydjA 4207747 ydjA Shigella flexneri 5 str. 8401 hypothetical protein YP_688948.1 1497161 D 373384 CDS YP_688949.1 110805429 4207748 1497811..1498854 1 NC_008258.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1498854 selD 4207748 selD Shigella flexneri 5 str. 8401 selenophosphate synthetase YP_688949.1 1497811 D 373384 CDS YP_688950.1 110805430 4207749 1498802..1500820 1 NC_008258.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1500820 topB 4207749 topB Shigella flexneri 5 str. 8401 DNA topoisomerase III YP_688950.1 1498802 D 373384 CDS YP_688951.1 110805431 4207750 1500948..1501646 1 NC_008258.1 hypothetical protein 1501646 4207750 SFV_1455 Shigella flexneri 5 str. 8401 hypothetical protein YP_688951.1 1500948 D 373384 CDS YP_688952.1 110805432 4207751 1501874..1502377 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1502377 insB 4207751 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688952.1 1501874 D 373384 CDS YP_688953.1 110805433 4207752 complement(1502882..1504225) 1 NC_008258.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1504225 gdhA 4207752 gdhA Shigella flexneri 5 str. 8401 glutamate dehydrogenase YP_688953.1 1502882 R 373384 CDS YP_688954.1 110805434 4207753 1504461..1504733 1 NC_008258.1 hypothetical protein 1504733 4207753 SFV_1458 Shigella flexneri 5 str. 8401 hypothetical protein YP_688954.1 1504461 D 373384 CDS YP_688955.1 110805435 4207754 complement(1504699..1505106) 1 NC_008258.1 Code: LR; COG: COG0494; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1505106 4207754 SFV_1459 Shigella flexneri 5 str. 8401 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_688955.1 1504699 R 373384 CDS YP_688956.1 110805436 4207755 1505193..1505750 1 NC_008258.1 Code: I; COG: COG0558; cytochrome oxidase 1505750 4207755 SFV_1460 Shigella flexneri 5 str. 8401 cytochrome oxidase YP_688956.1 1505193 D 373384 CDS YP_688957.1 110805437 4207757 complement(1507133..1507786) 1 NC_008258.1 Code: R; COG: COG4136; ABC transporter ATP-binding protein 1507786 4207757 SFV_1462 Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_688957.1 1507133 R 373384 CDS YP_688958.1 110805438 4207759 complement(1509276..1509731) 1 NC_008258.1 hypothetical protein 1509731 4207759 SFV_1464 Shigella flexneri 5 str. 8401 hypothetical protein YP_688958.1 1509276 R 373384 CDS YP_688959.1 110805439 4208091 1510159..1511505 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 1511505 4208091 SFV_1465 Shigella flexneri 5 str. 8401 IS4 orf YP_688959.1 1510159 D 373384 CDS YP_688960.1 110805440 4208092 complement(1511516..1511800) 1 NC_008258.1 hypothetical protein 1511800 4208092 SFV_1466 Shigella flexneri 5 str. 8401 hypothetical protein YP_688960.1 1511516 R 373384 CDS YP_688961.1 110805441 4208093 complement(1511855..1512403) 1 NC_008258.1 Code: S; COG: COG2128; hypothetical protein 1512403 ynjA 4208093 ynjA Shigella flexneri 5 str. 8401 hypothetical protein YP_688961.1 1511855 R 373384 CDS YP_688962.1 110805442 4208094 complement(1512403..1513107) 1 NC_008258.1 Code: S; COG: COG0398; hypothetical protein 1513107 ydjZ 4208094 ydjZ Shigella flexneri 5 str. 8401 hypothetical protein YP_688962.1 1512403 R 373384 CDS YP_688963.1 110805443 4208095 complement(1513125..1513802) 1 NC_008258.1 hypothetical protein 1513802 ydjY 4208095 ydjY Shigella flexneri 5 str. 8401 hypothetical protein YP_688963.1 1513125 R 373384 CDS YP_688964.1 110805444 4208096 complement(1513807..1514517) 1 NC_008258.1 Code: S; COG: COG0398; hypothetical protein 1514517 ydjX 4208096 ydjX Shigella flexneri 5 str. 8401 hypothetical protein YP_688964.1 1513807 R 373384 CDS YP_688965.1 110805445 4208097 complement(1514684..1515490) 1 NC_008258.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1515490 xthA 4208097 xthA Shigella flexneri 5 str. 8401 exonuclease III YP_688965.1 1514684 R 373384 CDS YP_688966.1 110805446 4208099 1517153..1518187 1 NC_008258.1 Code: E; COG: COG3138; arginine succinyltransferase 1518187 4208099 SFV_1473 Shigella flexneri 5 str. 8401 arginine succinyltransferase YP_688966.1 1517153 D 373384 CDS YP_688967.1 110805447 4208100 1518184..1519662 1 NC_008258.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1519662 astD 4208100 astD Shigella flexneri 5 str. 8401 succinylglutamic semialdehyde dehydrogenase YP_688967.1 1518184 D 373384 CDS YP_688968.1 110805448 4208102 1520985..1521953 1 NC_008258.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1521953 ydjS 4208102 ydjS Shigella flexneri 5 str. 8401 succinylglutamate desuccinylase YP_688968.1 1520985 D 373384 CDS YP_688969.1 110805449 4208103 1522283..1522768 1 NC_008258.1 related to spheroblast formation; periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; periplasmic protein 1522768 spy 4208103 spy Shigella flexneri 5 str. 8401 periplasmic protein YP_688969.1 1522283 D 373384 CDS YP_688970.1 110805450 4208104 1522908..1523546 1 NC_008258.1 Code: S; COG: COG3758; hypothetical protein 1523546 4208104 SFV_1478 Shigella flexneri 5 str. 8401 hypothetical protein YP_688970.1 1522908 D 373384 CDS YP_688971.1 110805451 4208105 complement(1523506..1524393) 1 NC_008258.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1524393 4208105 SFV_1479 Shigella flexneri 5 str. 8401 nucleotide excision repair endonuclease YP_688971.1 1523506 R 373384 CDS YP_688972.1 110805452 4208106 complement(1524623..1525450) 1 NC_008258.1 prefers NH3 over glutamine; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1525450 nadE 4208106 nadE Shigella flexneri 5 str. 8401 NAD synthetase YP_688972.1 1524623 R 373384 CDS YP_688973.1 110805453 4208107 1525652..1525990 1 NC_008258.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1525990 osmE 4208107 osmE Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator OsmE YP_688973.1 1525652 D 373384 CDS YP_688974.1 110805454 4208108 1526289..1526609 1 NC_008258.1 for cellobiose, arbutin, and salicin; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1526609 celA 4208108 celA Shigella flexneri 5 str. 8401 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_688974.1 1526289 D 373384 CDS YP_688975.1 110805455 4208109 1526694..1528043 1 NC_008258.1 for cellobiose, arbutin, and salicin; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1528043 celB 4208109 celB Shigella flexneri 5 str. 8401 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_688975.1 1526694 D 373384 CDS YP_688976.1 110805456 4207604 1527997..1528452 1 NC_008258.1 for cellobiose, arbutin, and salicin; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1528452 celC 4207604 celC Shigella flexneri 5 str. 8401 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_688976.1 1527997 D 373384 CDS YP_688977.1 110805457 4207606 1529407..1530759 1 NC_008258.1 Code: G; COG: COG1486; cryptic phospho-beta-glucosidase; cryptic 1530759 celF 4207606 celF Shigella flexneri 5 str. 8401 cryptic phospho-beta-glucosidase; cryptic YP_688977.1 1529407 D 373384 CDS YP_688978.1 110805458 4207607 1530772..1531530 1 NC_008258.1 Code: S; COG: COG3394; hypothetical protein 1531530 ydjC 4207607 ydjC Shigella flexneri 5 str. 8401 hypothetical protein YP_688978.1 1530772 D 373384 CDS YP_688979.1 110805459 4207608 complement(1531577..1533838) 1 NC_008258.1 hydroperoxidase HPII(III); Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1533838 katE 4207608 katE Shigella flexneri 5 str. 8401 hydroperoxidase II YP_688979.1 1531577 R 373384 CDS YP_688980.1 110805460 4207609 1534021..1534284 1 NC_008258.1 cell division modulator 1534284 4207609 SFV_1489 Shigella flexneri 5 str. 8401 cell division modulator YP_688980.1 1534021 D 373384 CDS YP_688981.1 110805461 4207612 complement(1536903..1537493) 1 NC_008258.1 Code: R; COG: COG1988; hypothetical protein 1537493 4207612 SFV_1493 Shigella flexneri 5 str. 8401 hypothetical protein YP_688981.1 1536903 R 373384 CDS YP_688982.1 110805462 4207613 complement(1537656..1538324) 1 NC_008258.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1538324 yniC 4207613 yniC Shigella flexneri 5 str. 8401 2-deoxyglucose-6-phosphatase YP_688982.1 1537656 R 373384 CDS YP_688983.1 110805463 4207614 1538471..1539007 1 NC_008258.1 hypothetical protein 1539007 4207614 SFV_1495 Shigella flexneri 5 str. 8401 hypothetical protein YP_688983.1 1538471 D 373384 CDS YP_688984.1 110805464 4207615 complement(1539048..1539908) 1 NC_008258.1 Code: G; COG: COG3001; hypothetical protein 1539908 4207615 SFV_1496 Shigella flexneri 5 str. 8401 hypothetical protein YP_688984.1 1539048 R 373384 CDS YP_688985.1 110805465 4207616 complement(1540014..1540304) 1 NC_008258.1 hypothetical protein 1540304 4207616 SFV_1497 Shigella flexneri 5 str. 8401 hypothetical protein YP_688985.1 1540014 R 373384 CDS YP_688986.1 110805466 4207617 complement(1540405..1541334) 1 NC_008258.1 Code: G; COG: COG1105; 6-phosphofructokinase 1541334 pfkB 4207617 pfkB Shigella flexneri 5 str. 8401 6-phosphofructokinase YP_688986.1 1540405 R 373384 CDS YP_688987.1 110805467 4207618 1541669..1542379 1 NC_008258.1 Code: M; COG: COG3137; hypothetical protein 1542379 4207618 SFV_1499 Shigella flexneri 5 str. 8401 hypothetical protein YP_688987.1 1541669 D 373384 CDS YP_688988.1 110805468 4207619 complement(1542432..1542650) 1 NC_008258.1 hypothetical protein 1542650 4207619 SFV_1500 Shigella flexneri 5 str. 8401 hypothetical protein YP_688988.1 1542432 R 373384 CDS YP_688989.1 110805469 4207620 complement(1543366..1543869) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1543869 insB 4207620 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_688989.1 1543366 R 373384 CDS YP_688990.1 110805470 4207621 1543944..1544162 1 NC_008258.1 IS1 encoded protein 1544162 4207621 SFV_1502 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_688990.1 1543944 D 373384 CDS YP_688991.1 110805471 4207623 1545022..1546950 1 NC_008258.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1546950 thrS 4207623 thrS Shigella flexneri 5 str. 8401 threonyl-tRNA synthetase YP_688991.1 1545022 D 373384 CDS YP_688992.1 110805472 4207832 1547062..1547496 1 NC_008258.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1547496 infC 4207832 infC Shigella flexneri 5 str. 8401 translation initiation factor IF-3 YP_688992.1 1547062 D 373384 CDS YP_688993.1 110805473 4207833 1547578..1547790 1 NC_008258.1 Code: J; COG: COG0291; 50S ribosomal protein L35 1547790 rpmI 4207833 rpmI Shigella flexneri 5 str. 8401 50S ribosomal protein L35 YP_688993.1 1547578 D 373384 CDS YP_688994.1 110805474 4207834 1547843..1548199 1 NC_008258.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1548199 rplT 4207834 rplT Shigella flexneri 5 str. 8401 50S ribosomal protein L20 YP_688994.1 1547843 D 373384 CDS YP_688995.1 110805475 4207835 1548326..1548460 1 NC_008258.1 phenylalanyl-tRNA synthetase (pheST) operon leader peptide 1548460 pheM 4207835 pheM Shigella flexneri 5 str. 8401 phenylalanyl-tRNA synthetase (pheST) operon leader peptide YP_688995.1 1548326 D 373384 CDS YP_688996.1 110805476 4207836 1548649..1549632 1 NC_008258.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1549632 pheS 4207836 pheS Shigella flexneri 5 str. 8401 phenylalanyl-tRNA synthetase subunit alpha YP_688996.1 1548649 D 373384 CDS YP_688997.1 110805477 4207837 1549647..1552034 1 NC_008258.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1552034 pheT 4207837 pheT Shigella flexneri 5 str. 8401 phenylalanyl-tRNA synthetase subunit beta YP_688997.1 1549647 D 373384 CDS YP_688998.1 110805478 4207838 1552039..1552338 1 NC_008258.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1552338 ihfA 4207838 ihfA Shigella flexneri 5 str. 8401 integration host factor subunit alpha YP_688998.1 1552039 D 373384 CDS YP_688999.1 110805479 4207839 1552439..1553419 1 NC_008258.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1553419 btuC 4207839 btuC Shigella flexneri 5 str. 8401 vtamin B12-transporter permease YP_688999.1 1552439 D 373384 CDS YP_689000.1 110805480 4207840 1553482..1554033 1 NC_008258.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 1554033 btuE 4207840 btuE Shigella flexneri 5 str. 8401 glutathione peroxidase YP_689000.1 1553482 D 373384 CDS YP_689001.1 110805481 4207841 1554033..1554782 1 NC_008258.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1554782 btuD 4207841 btuD Shigella flexneri 5 str. 8401 vitamin B12-transporter ATPase YP_689001.1 1554033 D 373384 CDS YP_689002.1 110805482 4207842 1554860..1555324 1 NC_008258.1 Code: M; COG: COG0791; lipoprotein 1555324 nlpC 4207842 nlpC Shigella flexneri 5 str. 8401 lipoprotein YP_689002.1 1554860 D 373384 CDS YP_689003.1 110805483 4207843 complement(1555475..1556821) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 1556821 4207843 SFV_1516 Shigella flexneri 5 str. 8401 IS4 orf YP_689003.1 1555475 R 373384 CDS YP_689004.1 110805484 4207844 1557009..1557722 1 NC_008258.1 Code: T; COG: COG2200; hypothetical protein 1557722 4207844 SFV_1517 Shigella flexneri 5 str. 8401 hypothetical protein YP_689004.1 1557009 D 373384 CDS YP_689005.1 110805485 4207845 1557732..1559222 1 NC_008258.1 Code: S; COG: COG0397; hypothetical protein 1559222 4207845 SFV_1518 Shigella flexneri 5 str. 8401 hypothetical protein YP_689005.1 1557732 D 373384 CDS YP_689006.1 110805486 4207846 complement(1559226..1559444) 1 NC_008258.1 Code: P; COG: COG4256; hypothetical protein 1559444 ydiE 4207846 ydiE Shigella flexneri 5 str. 8401 hypothetical protein YP_689006.1 1559226 R 373384 CDS YP_689007.1 110805487 4207847 complement(1559549..1560595) 1 NC_008258.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1560595 aroH 4207847 aroH Shigella flexneri 5 str. 8401 phospho-2-dehydro-3-deoxyheptonate aldolase YP_689007.1 1559549 R 373384 CDS YP_689008.1 110805488 4207848 complement(1560752..1561585) 1 NC_008258.1 Code: S; COG: COG1806; hypothetical protein 1561585 ydiA 4207848 ydiA Shigella flexneri 5 str. 8401 hypothetical protein YP_689008.1 1560752 R 373384 CDS YP_689009.1 110805489 4207849 1561917..1564295 1 NC_008258.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1564295 ppsA 4207849 ppsA Shigella flexneri 5 str. 8401 phosphoenolpyruvate synthase YP_689009.1 1561917 D 373384 CDS YP_689010.1 110805490 4207850 complement(1564352..1565998) 1 NC_008258.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1565998 ydiD 4207850 ydiD Shigella flexneri 5 str. 8401 short chain acyl-CoA synthetase YP_689010.1 1564352 R 373384 CDS YP_689011.1 110805491 4207889 complement(1566055..1566348) 1 NC_008258.1 Code: C; COG: COG2440; hypothetical protein 1566348 ydiT 4207889 ydiT Shigella flexneri 5 str. 8401 hypothetical protein YP_689011.1 1566055 R 373384 CDS YP_689012.1 110805492 4207890 complement(1566345..1567634) 1 NC_008258.1 Code: C; COG: COG0644; hypothetical protein 1567634 ydiS 4207890 ydiS Shigella flexneri 5 str. 8401 hypothetical protein YP_689012.1 1566345 R 373384 CDS YP_689013.1 110805493 4207891 complement(1567690..1568628) 1 NC_008258.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1568628 ydiR 4207891 ydiR Shigella flexneri 5 str. 8401 electron transfer flavoprotein subunit YdiR YP_689013.1 1567690 R 373384 CDS YP_689014.1 110805494 4207892 complement(1568648..1569412) 1 NC_008258.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 1569412 ydiQ 4207892 ydiQ Shigella flexneri 5 str. 8401 electron transfer flavoprotein YdiQ YP_689014.1 1568648 R 373384 CDS YP_689015.1 110805495 4207893 1569734..1570234 1 NC_008258.1 AraC family transcriptional regulator 1570234 4207893 SFV_1528 Shigella flexneri 5 str. 8401 AraC family transcriptional regulator YP_689015.1 1569734 D 373384 CDS YP_689016.1 110805496 4207894 complement(1570202..1570387) 1 NC_008258.1 IS1 encoded protein 1570387 4207894 SFV_1529 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689016.1 1570202 R 373384 CDS YP_689017.1 110805497 4207895 1570462..1570965 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1570965 insB 4207895 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689017.1 1570462 D 373384 CDS YP_689018.1 110805498 4207896 complement(1571528..1572289) 1 NC_008258.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1572289 4207896 SFV_1531 Shigella flexneri 5 str. 8401 transcriptional regulator YdeO YP_689018.1 1571528 R 373384 CDS YP_689019.1 110805499 4207897 complement(1572808..1575087) 1 NC_008258.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase; oxidoreductase 1575087 4207897 SFV_1532 Shigella flexneri 5 str. 8401 oxidoreductase YP_689019.1 1572808 R 373384 CDS YP_689020.1 110805500 4207898 complement(1575421..1576158) 1 NC_008258.1 fimbrial-like adhesin protein 1576158 4207898 SFV_1533 Shigella flexneri 5 str. 8401 fimbrial-like adhesin protein YP_689020.1 1575421 R 373384 CDS YP_689021.1 110805501 4207899 complement(1576130..1576345) 1 NC_008258.1 IS1 encoded protein 1576345 4207899 SFV_1534 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689021.1 1576130 R 373384 CDS YP_689022.1 110805502 4207900 1576420..1576923 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1576923 insB 4207900 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689022.1 1576420 D 373384 CDS YP_689023.1 110805503 4207901 1577106..1577819 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1577819 4207901 SFV_1536 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689023.1 1577106 D 373384 CDS YP_689024.1 110805504 4207902 complement(1578331..1578534) 1 NC_008258.1 hypothetical protein 1578534 4207902 SFV_1537 Shigella flexneri 5 str. 8401 hypothetical protein YP_689024.1 1578331 R 373384 CDS YP_689025.1 110805505 4207906 complement(1581259..1581615) 1 NC_008258.1 endonuclease of cryptic prophage 1581615 4207906 SFV_1541 Shigella flexneri 5 str. 8401 endonuclease of cryptic prophage YP_689025.1 1581259 R 373384 CDS YP_689026.1 110805506 4207959 complement(1581941..1582678) 1 NC_008258.1 hypothetical protein 1582678 4207959 SFV_1542 Shigella flexneri 5 str. 8401 hypothetical protein YP_689026.1 1581941 R 373384 CDS YP_689027.1 110805507 4207960 complement(1583025..1583276) 1 NC_008258.1 hypothetical protein 1583276 4207960 SFV_1543 Shigella flexneri 5 str. 8401 hypothetical protein YP_689027.1 1583025 R 373384 CDS YP_689028.1 110805508 4207961 complement(1584008..1584247) 1 NC_008258.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor; bifunctional antitoxin/transcriptional repressor RelB 1584247 relB 4207961 relB Shigella flexneri 5 str. 8401 bifunctional antitoxin/transcriptional repressor RelB YP_689028.1 1584008 R 373384 CDS YP_689029.1 110805509 4207962 complement(1584574..1585287) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1585287 4207962 SFV_1545 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689029.1 1584574 R 373384 CDS YP_689030.1 110805510 4207963 complement(1585428..1585730) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1585730 4207963 SFV_1546 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689030.1 1585428 R 373384 CDS YP_689031.1 110805511 4207964 1585807..1586811 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 1586811 4207964 SFV_1547 Shigella flexneri 5 str. 8401 transport protein YP_689031.1 1585807 D 373384 CDS YP_689032.1 110805512 4207965 1586900..1588360 1 NC_008258.1 Code: G; COG: COG0246; oxidoreductase 1588360 ydfI 4207965 ydfI Shigella flexneri 5 str. 8401 oxidoreductase YP_689032.1 1586900 D 373384 CDS YP_689033.1 110805513 4207966 complement(1588396..1588599) 1 NC_008258.1 hypothetical protein 1588599 4207966 SFV_1549 Shigella flexneri 5 str. 8401 hypothetical protein YP_689033.1 1588396 R 373384 CDS YP_689034.1 110805514 4207967 complement(1588777..1589415) 1 NC_008258.1 Code: K; COG: COG1802; hypothetical protein 1589415 ydfH 4207967 ydfH Shigella flexneri 5 str. 8401 hypothetical protein YP_689034.1 1588777 R 373384 CDS YP_689035.1 110805515 4207968 complement(1589552..1590298) 1 NC_008258.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1590298 ydfG 4207968 ydfG Shigella flexneri 5 str. 8401 3-hydroxy acid dehydrogenase YP_689035.1 1589552 R 373384 CDS YP_689036.1 110805516 4207969 1590435..1592480 1 NC_008258.1 Code: E; COG: COG0339; dipeptidyl carboxypeptidase II 1592480 dcp 4207969 dcp Shigella flexneri 5 str. 8401 dipeptidyl carboxypeptidase II YP_689036.1 1590435 D 373384 CDS YP_689037.1 110805517 4207970 complement(1592525..1593043) 1 NC_008258.1 Code: R; COG: COG1546; competence damage-inducible protein A 1593043 ydeJ 4207970 ydeJ Shigella flexneri 5 str. 8401 competence damage-inducible protein A YP_689037.1 1592525 R 373384 CDS YP_689038.1 110805518 4207971 1593319..1593552 1 NC_008258.1 hypothetical protein 1593552 ydeI 4207971 ydeI Shigella flexneri 5 str. 8401 hypothetical protein YP_689038.1 1593319 D 373384 CDS YP_689039.1 110805519 4207972 1593786..1593911 1 NC_008258.1 IS600 ORF1 1593911 4207972 SFV_1555 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689039.1 1593786 D 373384 CDS YP_689040.1 110805520 4207973 1594052..1594765 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1594765 4207973 SFV_1556 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689040.1 1594052 D 373384 CDS YP_689041.1 110805521 4207974 complement(1595939..1596910) 1 NC_008258.1 oxidoreductase, major subunit 1596910 4207974 SFV_1557 Shigella flexneri 5 str. 8401 oxidoreductase, major subunit YP_689041.1 1595939 R 373384 CDS YP_689042.1 110805522 4207975 complement(1597258..1597605) 1 NC_008258.1 hypothetical protein 1597605 4207975 SFV_1558 Shigella flexneri 5 str. 8401 hypothetical protein YP_689042.1 1597258 R 373384 CDS YP_689043.1 110805523 4207976 1597635..1598381 1 NC_008258.1 hypothetical protein 1598381 ynfC 4207976 ynfC Shigella flexneri 5 str. 8401 hypothetical protein YP_689043.1 1597635 D 373384 CDS YP_689044.1 110805524 4208016 complement(1598979..1599320) 1 NC_008258.1 hypothetical protein 1599320 4208016 SFV_1561 Shigella flexneri 5 str. 8401 hypothetical protein YP_689044.1 1598979 R 373384 CDS YP_689045.1 110805525 4208017 1599446..1599781 1 NC_008258.1 Code: S; COG: COG1742; hypothetical protein 1599781 4208017 SFV_1562 Shigella flexneri 5 str. 8401 hypothetical protein YP_689045.1 1599446 D 373384 CDS YP_689046.1 110805526 4208018 1599987..1601201 1 NC_008258.1 Code: MR; COG: COG4948; starvation sensing protein 1601201 rspA 4208018 rspA Shigella flexneri 5 str. 8401 starvation sensing protein YP_689046.1 1599987 D 373384 CDS YP_689047.1 110805527 4208019 1601278..1601556 1 NC_008258.1 Code: L; COG: COG2963; ISEhe3 orfA 1601556 4208019 SFV_1564 Shigella flexneri 5 str. 8401 ISEhe3 orfA YP_689047.1 1601278 D 373384 CDS YP_689048.2 162139343 4208020 complement(1601978..1602883) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1602883 4208020 SFV_1565 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_689048.2 1601978 R 373384 CDS YP_689049.1 110805529 4208021 complement(1602841..1603026) 1 NC_008258.1 IS2 orf1 1603026 4208021 SFV_1566 Shigella flexneri 5 str. 8401 IS2 orf1 YP_689049.1 1602841 R 373384 CDS YP_689050.1 110805530 4208022 complement(1603315..1604268) 1 NC_008258.1 Code: K; COG: COG2390; sorC family transcriptional regulator 1604268 ydeW 4208022 ydeW Shigella flexneri 5 str. 8401 sorC family transcriptional regulator YP_689050.1 1603315 R 373384 CDS YP_689051.1 110805531 4208023 1604517..1606052 1 NC_008258.1 Code: G; COG: COG1129; ABC transporter ATP-binding protein 1606052 4208023 SFV_1568 Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_689051.1 1604517 D 373384 CDS YP_689052.1 110805532 4208024 1606046..1607074 1 NC_008258.1 Code: G; COG: COG1172; transport system permease 1607074 ydeY 4208024 ydeY Shigella flexneri 5 str. 8401 transport system permease YP_689052.1 1606046 D 373384 CDS YP_689053.1 110805533 4208025 1607074..1608066 1 NC_008258.1 Code: G; COG: COG1172; transport system permease 1608066 ydeZ 4208025 ydeZ Shigella flexneri 5 str. 8401 transport system permease YP_689053.1 1607074 D 373384 CDS YP_689054.1 110805534 4208027 1609316..1609681 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1609681 4208027 SFV_1572 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689054.1 1609316 D 373384 CDS YP_689055.2 162139342 4208028 1609639..1610544 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1610544 4208028 SFV_1573 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_689055.2 1609639 D 373384 CDS YP_689056.1 110805536 4208029 1610569..1611339 1 NC_008258.1 Code: G; COG: COG1830; aldolase 1611339 yneB 4208029 yneB Shigella flexneri 5 str. 8401 aldolase YP_689056.1 1610569 D 373384 CDS YP_689057.1 110805537 4208030 1611363..1611653 1 NC_008258.1 Code: S; COG: COG1359; autoinducer-2 (AI-2) modifying protein LsrG 1611653 4208030 SFV_1575 Shigella flexneri 5 str. 8401 autoinducer-2 (AI-2) modifying protein LsrG YP_689057.1 1611363 D 373384 CDS YP_689058.1 110805538 4208031 1611693..1612451 1 NC_008258.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1612451 4208031 SFV_1576 Shigella flexneri 5 str. 8401 trans-aconitate 2-methyltransferase YP_689058.1 1611693 D 373384 CDS YP_689059.1 110805539 4208032 complement(1612455..1613420) 1 NC_008258.1 Code: S; COG: COG3781; hypothetical protein 1613420 4208032 SFV_1577 Shigella flexneri 5 str. 8401 hypothetical protein YP_689059.1 1612455 R 373384 CDS YP_689060.1 110805540 4208033 1613768..1614688 1 NC_008258.1 IS1294 orf 1614688 4208033 SFV_1578 Shigella flexneri 5 str. 8401 IS1294 orf YP_689060.1 1613768 D 373384 CDS YP_689061.1 110805541 4208034 1614701..1614835 1 NC_008258.1 IS1294 orf 1614835 4208034 SFV_1579 Shigella flexneri 5 str. 8401 IS1294 orf YP_689061.1 1614701 D 373384 CDS YP_689062.1 110805542 4208035 complement(1615263..1616714) 1 NC_008258.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1616714 uxaB 4208035 uxaB Shigella flexneri 5 str. 8401 altronate oxidoreductase YP_689062.1 1615263 R 373384 CDS YP_689063.1 110805543 4208036 complement(1616941..1618359) 1 NC_008258.1 hypothetical protein 1618359 4208036 SFV_1581 Shigella flexneri 5 str. 8401 hypothetical protein YP_689063.1 1616941 R 373384 CDS YP_689064.1 110805544 4208037 complement(1618498..1618857) 1 NC_008258.1 hypothetical protein 1618857 4208037 SFV_1582 Shigella flexneri 5 str. 8401 hypothetical protein YP_689064.1 1618498 R 373384 CDS YP_689065.1 110805545 4208038 complement(1618886..1619680) 1 NC_008258.1 Code: E; COG: COG2066; glutaminase 1619680 yneH 4208038 yneH Shigella flexneri 5 str. 8401 glutaminase YP_689065.1 1618886 R 373384 CDS YP_689066.1 110805546 4208040 complement(1620742..1620924) 1 NC_008258.1 IS1 encoded protein 1620924 4208040 SFV_1585 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689066.1 1620742 R 373384 CDS YP_689067.1 110805547 4208041 1620999..1621502 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1621502 insB 4208041 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689067.1 1620999 D 373384 CDS YP_689068.1 110805548 4208042 1621572..1622687 1 NC_008258.1 hypothetical protein 1622687 4208042 SFV_1587 Shigella flexneri 5 str. 8401 hypothetical protein YP_689068.1 1621572 D 373384 CDS YP_689069.1 110805549 4208043 1622837..1624027 1 NC_008258.1 Code: G; COG: COG2814; sugar efflux transporter 1624027 ydeA 4208043 ydeA Shigella flexneri 5 str. 8401 sugar efflux transporter YP_689069.1 1622837 D 373384 CDS YP_689070.1 110805550 4208044 complement(1624052..1624717) 1 NC_008258.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1624717 ydeB 4208044 ydeB Shigella flexneri 5 str. 8401 multiple drug resistance protein MarC YP_689070.1 1624052 R 373384 CDS YP_689071.1 110805551 4208045 1624929..1625363 1 NC_008258.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1625363 marR 4208045 marR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor MarR YP_689071.1 1624929 D 373384 CDS YP_689072.2 162139341 4208046 1625383..1625766 1 NC_008258.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1625766 marA 4208046 marA Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator MarA YP_689072.2 1625383 D 373384 CDS YP_689073.1 110805553 4208047 1625798..1626016 1 NC_008258.1 hypothetical protein 1626016 marB 4208047 marB Shigella flexneri 5 str. 8401 hypothetical protein YP_689073.1 1625798 D 373384 CDS YP_689074.1 110805554 4208048 complement(1626047..1626946) 1 NC_008258.1 Code: GER; COG: COG0697; O-acetylserine/cysteine export protein 1626946 ydeD 4208048 ydeD Shigella flexneri 5 str. 8401 O-acetylserine/cysteine export protein YP_689074.1 1626047 R 373384 CDS YP_689075.1 110805555 4208049 1627210..1628328 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 1628328 ydeF 4208049 ydeF Shigella flexneri 5 str. 8401 transport protein YP_689075.1 1627210 D 373384 CDS YP_689076.1 110805556 4208050 complement(1628799..1629512) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1629512 4208050 SFV_1595 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689076.1 1628799 R 373384 CDS YP_689077.1 110805557 4208051 complement(1629653..1629778) 1 NC_008258.1 IS600 ORF1 1629778 4208051 SFV_1596 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689077.1 1629653 R 373384 CDS YP_689078.1 110805558 4208052 complement(1630017..1630577) 1 NC_008258.1 hypothetical protein 1630577 4208052 SFV_1597 Shigella flexneri 5 str. 8401 hypothetical protein YP_689078.1 1630017 R 373384 CDS YP_689079.1 110805559 4208053 1630728..1631402 1 NC_008258.1 ISSfl4 ORF1 1631402 4208053 SFV_1598 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_689079.1 1630728 D 373384 CDS YP_689080.1 110805560 4208054 1631476..1631802 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 1631802 4208054 SFV_1599 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_689080.1 1631476 D 373384 CDS YP_689081.1 110805561 4208110 1632038..1632685 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 1632685 4208110 SFV_1600 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_689081.1 1632038 D 373384 CDS YP_689082.1 110805563 4208112 complement(1632725..1633525) 1 NC_008258.1 integrase 1633525 4208112 SFV_1602 Shigella flexneri 5 str. 8401 integrase YP_689082.1 1632725 R 373384 CDS YP_689083.1 110805562 4208111 1633508..1634617 1 NC_008258.1 oxidoreductase, major subunit 1634617 4208111 SFV_1601 Shigella flexneri 5 str. 8401 oxidoreductase, major subunit YP_689083.1 1633508 D 373384 CDS YP_689084.1 110805564 4208114 1636727..1637344 1 NC_008258.1 Code: C; COG: COG0437; oxidoreductase, Fe-S subunit 1637344 4208114 SFV_1604 Shigella flexneri 5 str. 8401 oxidoreductase, Fe-S subunit YP_689084.1 1636727 D 373384 CDS YP_689085.1 110805565 4208115 1637346..1638200 1 NC_008258.1 Code: R; COG: COG3302; DMSO reductase anchor subunit 1638200 4208115 SFV_1605 Shigella flexneri 5 str. 8401 DMSO reductase anchor subunit YP_689085.1 1637346 D 373384 CDS YP_689086.1 110805566 4208117 1638992..1640308 1 NC_008258.1 Code: P; COG: COG0038; voltage-gated ClC-type chloride channel ClcB 1640308 4208117 SFV_1607 Shigella flexneri 5 str. 8401 voltage-gated ClC-type chloride channel ClcB YP_689086.1 1638992 D 373384 CDS YP_689087.1 110805567 4208118 complement(1640261..1640956) 1 NC_008258.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1640956 4208118 SFV_1608 Shigella flexneri 5 str. 8401 dithiobiotin synthetase YP_689087.1 1640261 R 373384 CDS YP_689088.1 110805568 4208119 complement(1641081..1642301) 1 NC_008258.1 Code: KG; COG: COG1940; NAGC-like transcriptional regulator 1642301 mlc 4208119 mlc Shigella flexneri 5 str. 8401 NAGC-like transcriptional regulator YP_689088.1 1641081 R 373384 CDS YP_689089.1 110805569 4208120 complement(1642436..1643338) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1643338 ynfL 4208120 ynfL Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_689089.1 1642436 R 373384 CDS YP_689090.1 110805570 4208122 1645095..1645430 1 NC_008258.1 required for growth and survival under moderately acid conditions; acid shock protein 1645430 asr 4208122 asr Shigella flexneri 5 str. 8401 acid shock protein YP_689090.1 1645095 D 373384 CDS YP_689091.1 110805571 4208123 1645706..1646527 1 NC_008258.1 Code: E; COG: COG3591; hypothetical protein 1646527 4208123 SFV_1613 Shigella flexneri 5 str. 8401 hypothetical protein YP_689091.1 1645706 D 373384 CDS YP_689092.1 110805572 4208124 complement(1646566..1646895) 1 NC_008258.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1646895 4208124 SFV_1614 Shigella flexneri 5 str. 8401 multidrug efflux system protein MdtI YP_689092.1 1646566 R 373384 CDS YP_689093.1 110805573 4208125 complement(1646882..1647247) 1 NC_008258.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1647247 4208125 SFV_1615 Shigella flexneri 5 str. 8401 multidrug efflux system protein MdtJ YP_689093.1 1646882 R 373384 CDS YP_689094.1 110805574 4208126 1647658..1648692 1 NC_008258.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transport protein 1648692 tqsA 4208126 tqsA Shigella flexneri 5 str. 8401 transport protein YP_689094.1 1647658 D 373384 CDS YP_689095.1 110805575 4208127 complement(1648717..1650105) 1 NC_008258.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1650105 pntB 4208127 pntB Shigella flexneri 5 str. 8401 pyridine nucleotide transhydrogenase YP_689095.1 1648717 R 373384 CDS YP_689096.1 110805576 4208128 complement(1650116..1651663) 1 NC_008258.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1651663 pntA 4208128 pntA Shigella flexneri 5 str. 8401 NAD(P) transhydrogenase subunit alpha YP_689096.1 1650116 R 373384 CDS YP_689097.1 110805577 4208129 1652172..1653116 1 NC_008258.1 hypothetical protein 1653116 4208129 SFV_1619 Shigella flexneri 5 str. 8401 hypothetical protein YP_689097.1 1652172 D 373384 CDS YP_689098.1 110805578 4210786 1653302..1654684 1 NC_008258.1 Code: E; COG: COG0531; arginine/ornithine antiporter 1654684 4210786 SFV_1620 Shigella flexneri 5 str. 8401 arginine/ornithine antiporter YP_689098.1 1653302 D 373384 CDS YP_689099.1 110805579 4210787 1654721..1655443 1 NC_008258.1 Code: IQR; COG: COG1028; short chain dehydrogenase 1655443 ydgB 4210787 ydgB Shigella flexneri 5 str. 8401 short chain dehydrogenase YP_689099.1 1654721 D 373384 CDS YP_689100.1 110805580 4210788 complement(1655440..1655775) 1 NC_008258.1 Code: R; COG: COG3136; hypothetical protein 1655775 ydgC 4210788 ydgC Shigella flexneri 5 str. 8401 hypothetical protein YP_689100.1 1655440 R 373384 CDS YP_689101.1 110805581 4210789 1655844..1656647 1 NC_008258.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1656647 rstA 4210789 rstA Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator RstA YP_689101.1 1655844 D 373384 CDS YP_689102.1 110805582 4210790 1656872..1658191 1 NC_008258.1 Code: R; COG: COG1823; transporter 1658191 4210790 SFV_1624 Shigella flexneri 5 str. 8401 transporter YP_689102.1 1656872 D 373384 CDS YP_689103.1 110805583 4210791 1658370..1659671 1 NC_008258.1 Code: T; COG: COG0642; sensor protein RstB 1659671 rstB 4210791 rstB Shigella flexneri 5 str. 8401 sensor protein RstB YP_689103.1 1658370 D 373384 CDS YP_689104.1 110805584 4210792 1659747..1660676 1 NC_008258.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1660676 tus 4210792 tus Shigella flexneri 5 str. 8401 DNA replication terminus site-binding protein YP_689104.1 1659747 D 373384 CDS YP_689105.1 110805585 4210793 complement(1660673..1662076) 1 NC_008258.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1662076 fumC 4210793 fumC Shigella flexneri 5 str. 8401 fumarate hydratase YP_689105.1 1660673 R 373384 CDS YP_689106.1 110805586 4210794 complement(1662219..1663865) 1 NC_008258.1 Code: C; COG: COG1951; fumarate hydratase class I, aerobic 1663865 fumA 4210794 fumA Shigella flexneri 5 str. 8401 fumarate hydratase class I, aerobic YP_689106.1 1662219 R 373384 CDS YP_689107.1 110805587 4210795 1664064..1665239 1 NC_008258.1 Code: G; COG: COG1482; mannose-6-phosphate isomerase 1665239 manA 4210795 manA Shigella flexneri 5 str. 8401 mannose-6-phosphate isomerase YP_689107.1 1664064 D 373384 CDS YP_689108.1 110805588 4210796 1665340..1666848 1 NC_008258.1 Code: S; COG: COG5339; hypothetical protein 1666848 ydgA 4210796 ydgA Shigella flexneri 5 str. 8401 hypothetical protein YP_689108.1 1665340 D 373384 CDS YP_689109.1 110805589 4210797 complement(1667168..1668340) 1 NC_008258.1 membrane-associated protein 1668340 uidC 4210797 uidC Shigella flexneri 5 str. 8401 membrane-associated protein YP_689109.1 1667168 R 373384 CDS YP_689110.1 110805590 4210799 complement(1669749..1671560) 1 NC_008258.1 Code: G; COG: COG3250; beta-D-glucuronidase 1671560 uidA 4210799 uidA Shigella flexneri 5 str. 8401 beta-D-glucuronidase YP_689110.1 1669749 R 373384 CDS YP_689111.1 110805591 4210800 complement(1671948..1672538) 1 NC_008258.1 Code: K; COG: COG1309; repressor for uid operon 1672538 uidR 4210800 uidR Shigella flexneri 5 str. 8401 repressor for uid operon YP_689111.1 1671948 R 373384 CDS YP_689112.1 110805592 4210801 complement(1672943..1673446) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1673446 insB 4210801 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689112.1 1672943 R 373384 CDS YP_689113.1 110805593 4210803 complement(1674423..1675451) 1 NC_008258.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1675451 malI 4210803 malI Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor MalI YP_689113.1 1674423 R 373384 CDS YP_689114.1 110805594 4210804 1675626..1677218 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1677218 malX 4210804 malX Shigella flexneri 5 str. 8401 bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_689114.1 1675626 D 373384 CDS YP_689115.1 110805595 4209307 1677249..1678400 1 NC_008258.1 Code: E; COG: COG1168; cystathionine beta-lyase 1678400 malY 4209307 malY Shigella flexneri 5 str. 8401 cystathionine beta-lyase YP_689115.1 1677249 D 373384 CDS YP_689116.1 110805596 4209308 1678504..1679505 1 NC_008258.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1679505 add 4209308 add Shigella flexneri 5 str. 8401 adenosine deaminase YP_689116.1 1678504 D 373384 CDS YP_689117.1 110805597 4209309 complement(1679541..1680515) 1 NC_008258.1 Code: R; COG: COG0673; oxidoreductase 1680515 4209309 SFV_1641 Shigella flexneri 5 str. 8401 oxidoreductase YP_689117.1 1679541 R 373384 CDS YP_689118.1 110805598 4209310 1681156..1681371 1 NC_008258.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1681371 4209310 SFV_1642 Shigella flexneri 5 str. 8401 oriC-binding nucleoid-associated protein YP_689118.1 1681156 D 373384 CDS YP_689119.1 110805599 4209311 1681457..1681897 1 NC_008258.1 hypothetical protein 1681897 4209311 SFV_1643 Shigella flexneri 5 str. 8401 hypothetical protein YP_689119.1 1681457 D 373384 CDS YP_689120.1 110805600 4209312 1681974..1682555 1 NC_008258.1 Code: C; COG: COG4657; Na(+)-translocating NADH-quinone reductase subunit E 1682555 4209312 SFV_1644 Shigella flexneri 5 str. 8401 Na(+)-translocating NADH-quinone reductase subunit E YP_689120.1 1681974 D 373384 CDS YP_689121.1 110805601 4209313 1682555..1683133 1 NC_008258.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1683133 4209313 SFV_1645 Shigella flexneri 5 str. 8401 electron transport complex protein RnfB YP_689121.1 1682555 D 373384 CDS YP_689122.1 110805602 4209314 1683126..1685348 1 NC_008258.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1685348 4209314 SFV_1646 Shigella flexneri 5 str. 8401 electron transport complex protein RnfC YP_689122.1 1683126 D 373384 CDS YP_689123.1 110805603 4209315 1685349..1686407 1 NC_008258.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1686407 rnfD 4209315 rnfD Shigella flexneri 5 str. 8401 electron transport complex protein RnfD YP_689123.1 1685349 D 373384 CDS YP_689124.1 110805604 4209316 1686411..1687031 1 NC_008258.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1687031 4209316 SFV_1648 Shigella flexneri 5 str. 8401 electron transport complex protein RnfG YP_689124.1 1686411 D 373384 CDS YP_689125.1 110805605 4209317 1687035..1687730 1 NC_008258.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex RsxE subunit 1687730 ydgQ 4209317 ydgQ Shigella flexneri 5 str. 8401 electron transport complex RsxE subunit YP_689125.1 1687035 D 373384 CDS YP_689126.1 110805606 4209318 1687730..1688365 1 NC_008258.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1688365 nth 4209318 nth Shigella flexneri 5 str. 8401 endonuclease III YP_689126.1 1687730 D 373384 CDS YP_689127.1 110805607 4209319 1688976..1690478 1 NC_008258.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1690478 tppB 4209319 tppB Shigella flexneri 5 str. 8401 tripeptide transporter permease YP_689127.1 1688976 D 373384 CDS YP_689128.1 110805608 4209320 1690583..1691188 1 NC_008258.1 Code: O; COG: COG0625; glutathionine S-transferase 1691188 gst 4209320 gst Shigella flexneri 5 str. 8401 glutathionine S-transferase YP_689128.1 1690583 D 373384 CDS YP_689129.1 110805609 4209321 complement(1691232..1692092) 1 NC_008258.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1692092 pdxY 4209321 pdxY Shigella flexneri 5 str. 8401 pyridoxamine kinase YP_689129.1 1691232 R 373384 CDS YP_689130.1 110805610 4209322 complement(1692154..1693428) 1 NC_008258.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1693428 tyrS 4209322 tyrS Shigella flexneri 5 str. 8401 tyrosyl-tRNA synthetase YP_689130.1 1692154 R 373384 CDS YP_689131.1 110805611 4209323 complement(1693557..1694213) 1 NC_008258.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1694213 pdxH 4209323 pdxH Shigella flexneri 5 str. 8401 pyridoxamine 5'-phosphate oxidase YP_689131.1 1693557 R 373384 CDS YP_689132.1 110805612 4209324 complement(1694272..1694520) 1 NC_008258.1 Code: R; COG: COG3895; hypothetical protein 1694520 ydhA 4209324 ydhA Shigella flexneri 5 str. 8401 hypothetical protein YP_689132.1 1694272 R 373384 CDS YP_689133.1 110805613 4209325 complement(1694542..1695381) 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 1695381 4209325 SFV_1657 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_689133.1 1694542 R 373384 CDS YP_689134.1 110805614 4209326 complement(1695405..1695815) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1695815 4209326 SFV_1658 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689134.1 1695405 R 373384 CDS YP_689135.1 110805615 4209136 complement(1696035..1697144) 1 NC_008258.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1697144 anmK 4209136 anmK Shigella flexneri 5 str. 8401 anhydro-N-acetylmuramic acid kinase YP_689135.1 1696035 R 373384 CDS YP_689136.1 110805616 4209137 1697418..1697885 1 NC_008258.1 Code: M; COG: COG3133; outer membrane protein 1697885 slyB 4209137 slyB Shigella flexneri 5 str. 8401 outer membrane protein YP_689136.1 1697418 D 373384 CDS YP_689137.1 110805617 4209138 complement(1697932..1698372) 1 NC_008258.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1698372 slyA 4209138 slyA Shigella flexneri 5 str. 8401 transcriptional regulator SlyA YP_689137.1 1697932 R 373384 CDS YP_689138.1 110805618 4209139 1698576..1698803 1 NC_008258.1 hypothetical protein 1698803 4209139 SFV_1662 Shigella flexneri 5 str. 8401 hypothetical protein YP_689138.1 1698576 D 373384 CDS YP_689139.1 110805619 4209140 1698797..1699663 1 NC_008258.1 Code: V; COG: COG1566; hypothetical protein 1699663 4209140 SFV_1663 Shigella flexneri 5 str. 8401 hypothetical protein YP_689139.1 1698797 D 373384 CDS YP_689140.1 110805620 4209141 1699663..1699989 1 NC_008258.1 hypothetical protein 1699989 4209141 SFV_1664 Shigella flexneri 5 str. 8401 hypothetical protein YP_689140.1 1699663 D 373384 CDS YP_689141.1 110805621 4209142 1700161..1701675 1 NC_008258.1 Code: S; COG: COG1289; hypothetical protein 1701675 4209142 SFV_1665 Shigella flexneri 5 str. 8401 hypothetical protein YP_689141.1 1700161 D 373384 CDS YP_689142.1 110805622 4209143 complement(1701676..1702197) 1 NC_008258.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1702197 sodC 4209143 sodC Shigella flexneri 5 str. 8401 superoxide dismutase YP_689142.1 1701676 R 373384 CDS YP_689143.1 110805623 4209144 complement(1702278..1703174) 1 NC_008258.1 Code: R; COG: COG4989; hypothetical protein 1703174 4209144 SFV_1667 Shigella flexneri 5 str. 8401 hypothetical protein YP_689143.1 1702278 R 373384 CDS YP_689144.1 110805625 4209146 complement(1703223..1703600) 1 NC_008258.1 hypothetical protein 1703600 4209146 SFV_1669 Shigella flexneri 5 str. 8401 hypothetical protein YP_689144.1 1703223 R 373384 CDS YP_689145.1 110805624 4209145 1703565..1704164 1 NC_008258.1 Code: K; COG: COG1309; hypothetical protein 1704164 4209145 SFV_1668 Shigella flexneri 5 str. 8401 hypothetical protein YP_689145.1 1703565 D 373384 CDS YP_689146.1 110805626 4209147 1704201..1705298 1 NC_008258.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1705298 nemA 4209147 nemA Shigella flexneri 5 str. 8401 N-ethylmaleimide reductase YP_689146.1 1704201 D 373384 CDS YP_689147.1 110805627 4209148 1705379..1705786 1 NC_008258.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1705786 gloA 4209148 gloA Shigella flexneri 5 str. 8401 glyoxalase I YP_689147.1 1705379 D 373384 CDS YP_689148.1 110805628 4209149 1705889..1706536 1 NC_008258.1 degrades tRNA; Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1706536 rnt 4209149 rnt Shigella flexneri 5 str. 8401 ribonuclease T YP_689148.1 1705889 D 373384 CDS YP_689149.1 110805629 4209150 1706668..1710045 1 NC_008258.1 Code: R; COG: COG1201; ATP-dependent helicase superfamily protein 1710045 lhr 4209150 lhr Shigella flexneri 5 str. 8401 ATP-dependent helicase superfamily protein YP_689149.1 1706668 D 373384 CDS YP_689150.1 110805630 4209151 1709990..1711087 1 NC_008258.1 ATP-dependent helicase superfamily protein 1711087 4209151 SFV_1674 Shigella flexneri 5 str. 8401 ATP-dependent helicase superfamily protein YP_689150.1 1709990 D 373384 CDS YP_689151.1 110805631 4209152 complement(1711131..1712279) 1 NC_008258.1 Code: L; COG: COG0675; virulence protein 1712279 4209152 SFV_1675 Shigella flexneri 5 str. 8401 virulence protein YP_689151.1 1711131 R 373384 CDS YP_689152.1 110805632 4209153 complement(1712890..1713237) 1 NC_008258.1 Code: O; COG: COG0278; hypothetical protein 1713237 ydhD 4209153 ydhD Shigella flexneri 5 str. 8401 hypothetical protein YP_689152.1 1712890 R 373384 CDS YP_689153.1 110805633 4209154 1713572..1714399 1 NC_008258.1 Code: M; COG: COG0791; lipoprotein 1714399 ydhO 4209154 ydhO Shigella flexneri 5 str. 8401 lipoprotein YP_689153.1 1713572 D 373384 CDS YP_689154.1 110805634 4208818 1714527..1715108 1 NC_008258.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1715108 sodB 4208818 sodB Shigella flexneri 5 str. 8401 superoxide dismutase YP_689154.1 1714527 D 373384 CDS YP_689155.1 110805635 4208819 complement(1715254..1716423) 1 NC_008258.1 Code: G; COG: COG2814; transport protein 1716423 4208819 SFV_1679 Shigella flexneri 5 str. 8401 transport protein YP_689155.1 1715254 R 373384 CDS YP_689156.1 110805636 4208820 1716977..1718002 1 NC_008258.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1718002 purR 4208820 purR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor PurR YP_689156.1 1716977 D 373384 CDS YP_689157.1 110805637 4208821 complement(1717999..1718931) 1 NC_008258.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 1718931 ydhB 4208821 ydhB Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_689157.1 1717999 R 373384 CDS YP_689158.1 110805638 4208822 1719044..1720255 1 NC_008258.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1720255 ydhC 4208822 ydhC Shigella flexneri 5 str. 8401 inner membrane transport protein YdhC YP_689158.1 1719044 D 373384 CDS YP_689159.1 110805639 4208823 1720546..1721694 1 NC_008258.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane fatty acyl phospholipid synthase 1721694 cfa 4208823 cfa Shigella flexneri 5 str. 8401 cyclopropane fatty acyl phospholipid synthase YP_689159.1 1720546 D 373384 CDS YP_689160.1 110805640 4208824 complement(1721734..1722375) 1 NC_008258.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1722375 ribE 4208824 ribE Shigella flexneri 5 str. 8401 riboflavin synthase subunit alpha YP_689160.1 1721734 R 373384 CDS YP_689161.1 110805641 4208825 1722590..1723963 1 NC_008258.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1723963 ydhE 4208825 ydhE Shigella flexneri 5 str. 8401 multidrug efflux protein YP_689161.1 1722590 D 373384 CDS YP_689162.1 110805642 4208826 complement(1724004..1725260) 1 NC_008258.1 Code: MU; COG: COG3468; hypothetical protein 1725260 4208826 SFV_1686 Shigella flexneri 5 str. 8401 hypothetical protein YP_689162.1 1724004 R 373384 CDS YP_689163.1 110805643 4208829 1725833..1726138 1 NC_008258.1 hypothetical protein 1726138 4208829 SFV_1689 Shigella flexneri 5 str. 8401 hypothetical protein YP_689163.1 1725833 D 373384 CDS YP_689164.1 110805644 4208830 1726264..1727868 1 NC_008258.1 Code: S; COG: COG4529; hypothetical protein 1727868 4208830 SFV_1690 Shigella flexneri 5 str. 8401 hypothetical protein YP_689164.1 1726264 D 373384 CDS YP_689165.1 110805645 4208831 complement(1727880..1728629) 1 NC_008258.1 hypothetical protein 1728629 4208831 SFV_1691 Shigella flexneri 5 str. 8401 hypothetical protein YP_689165.1 1727880 R 373384 CDS YP_689166.1 110805646 4208832 complement(1728681..1729466) 1 NC_008258.1 Code: C; COG: COG4117; hypothetical protein 1729466 ydhU 4208832 ydhU Shigella flexneri 5 str. 8401 hypothetical protein YP_689166.1 1728681 R 373384 CDS YP_689167.1 110805647 4208833 complement(1729463..1730131) 1 NC_008258.1 Code: C; COG: COG0437; oxidoreductase, Fe-S subunit 1730131 4208833 SFV_1693 Shigella flexneri 5 str. 8401 oxidoreductase, Fe-S subunit YP_689167.1 1729463 R 373384 CDS YP_689168.1 110805648 4208834 complement(1730195..1730842) 1 NC_008258.1 hypothetical protein 1730842 4208834 SFV_1694 Shigella flexneri 5 str. 8401 hypothetical protein YP_689168.1 1730195 R 373384 CDS YP_689169.1 110805649 4208835 complement(1730846..1732642) 1 NC_008258.1 Code: C; COG: COG2414; hypothetical protein 1732642 4208835 SFV_1695 Shigella flexneri 5 str. 8401 hypothetical protein YP_689169.1 1730846 R 373384 CDS YP_689170.1 110805650 4208727 complement(1732968..1733594) 1 NC_008258.1 Code: C; COG: COG0437; hypothetical protein 1733594 4208727 SFV_1696 Shigella flexneri 5 str. 8401 hypothetical protein YP_689170.1 1732968 R 373384 CDS YP_689171.1 110805651 4208728 complement(1734051..1734260) 1 NC_008258.1 hypothetical protein 1734260 4208728 SFV_1697 Shigella flexneri 5 str. 8401 hypothetical protein YP_689171.1 1734051 R 373384 CDS YP_689172.1 110805652 4208729 1734541..1735044 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1735044 insB 4208729 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689172.1 1734541 D 373384 CDS YP_689173.1 110805653 4208730 1735377..1737005 1 NC_008258.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1737005 pykF 4208730 pykF Shigella flexneri 5 str. 8401 pyruvate kinase YP_689173.1 1735377 D 373384 CDS YP_689174.1 110805654 4208731 1737317..1737553 1 NC_008258.1 Code: M; COG: COG4238; murein lipoprotein 1737553 lpp 4208731 lpp Shigella flexneri 5 str. 8401 murein lipoprotein YP_689174.1 1737317 D 373384 CDS YP_689175.1 110805655 4208732 complement(1737616..1738620) 1 NC_008258.1 Code: S; COG: COG1376; hypothetical protein 1738620 ynhG 4208732 ynhG Shigella flexneri 5 str. 8401 hypothetical protein YP_689175.1 1737616 R 373384 CDS YP_689176.1 110805656 4208733 complement(1738769..1739185) 1 NC_008258.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1739185 ynhA 4208733 ynhA Shigella flexneri 5 str. 8401 cysteine desufuration protein SufE YP_689176.1 1738769 R 373384 CDS YP_689177.1 110805657 4208734 complement(1739198..1740418) 1 NC_008258.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1740418 4208734 SFV_1703 Shigella flexneri 5 str. 8401 bifunctional cysteine desulfurase/selenocysteine lyase YP_689177.1 1739198 R 373384 CDS YP_689178.1 110805658 4208735 complement(1740415..1741581) 1 NC_008258.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase 1741581 ynhC 4208735 ynhC Shigella flexneri 5 str. 8401 cysteine desulfurase YP_689178.1 1740415 R 373384 CDS YP_689179.1 110805659 4208736 complement(1741660..1742406) 1 NC_008258.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 1742406 sufC 4208736 sufC Shigella flexneri 5 str. 8401 cysteine desulfurase YP_689179.1 1741660 R 373384 CDS YP_689180.1 110805660 4208737 complement(1742416..1743903) 1 NC_008258.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase 1743903 ynhE 4208737 ynhE Shigella flexneri 5 str. 8401 cysteine desulfurase YP_689180.1 1742416 R 373384 CDS YP_689181.1 110805661 4208738 complement(1743912..1744280) 1 NC_008258.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1744280 sufA 4208738 sufA Shigella flexneri 5 str. 8401 iron-sulfur cluster assembly scaffold protein YP_689181.1 1743912 R 373384 CDS YP_689182.1 110805662 4208739 complement(1744828..1745097) 1 NC_008258.1 hypothetical protein 1745097 4208739 SFV_1708 Shigella flexneri 5 str. 8401 hypothetical protein YP_689182.1 1744828 R 373384 CDS YP_689183.1 110805663 4208740 complement(1745116..1745526) 1 NC_008258.1 Code: Q; COG: COG2050; hypothetical protein 1745526 4208740 SFV_1709 Shigella flexneri 5 str. 8401 hypothetical protein YP_689183.1 1745116 R 373384 CDS YP_689184.1 110805664 4208741 complement(1745523..1748579) 1 NC_008258.1 oxidase 1748579 ydiJ 4208741 ydiJ Shigella flexneri 5 str. 8401 oxidase YP_689184.1 1745523 R 373384 CDS YP_689185.1 110805665 4208742 1748968..1750080 1 NC_008258.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; inner membrane protein 1750080 4208742 SFV_1711 Shigella flexneri 5 str. 8401 inner membrane protein YP_689185.1 1748968 D 373384 CDS YP_689186.1 110805666 4208743 1750481..1750864 1 NC_008258.1 hypothetical protein 1750864 4208743 SFV_1712 Shigella flexneri 5 str. 8401 hypothetical protein YP_689186.1 1750481 D 373384 CDS YP_689187.1 110805667 4208745 1752034..1752537 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1752537 insB 4208745 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689187.1 1752034 D 373384 CDS YP_689188.1 110805668 4208478 1753249..1754409 1 NC_008258.1 Code: GEPR; COG: COG0477; amino acid/amine transport protein 1754409 4208478 SFV_1715 Shigella flexneri 5 str. 8401 amino acid/amine transport protein YP_689188.1 1753249 D 373384 CDS YP_689189.1 110805669 4208479 complement(1754530..1754709) 1 NC_008258.1 IS1 encoded protein 1754709 4208479 SFV_1716 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689189.1 1754530 R 373384 CDS YP_689190.1 110805670 4208480 1754784..1755287 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1755287 insB 4208480 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689190.1 1754784 D 373384 CDS YP_689191.1 110805671 4208481 1755314..1756063 1 NC_008258.1 Code: E; COG: COG0169; quinate/shikimate dehydrogenase 1756063 ydiB 4208481 ydiB Shigella flexneri 5 str. 8401 quinate/shikimate dehydrogenase YP_689191.1 1755314 D 373384 CDS YP_689192.1 110805672 4208482 1756094..1756852 1 NC_008258.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1756852 aroD 4208482 aroD Shigella flexneri 5 str. 8401 3-dehydroquinate dehydratase YP_689192.1 1756094 D 373384 CDS YP_689193.1 110805673 4208483 complement(1756934..1757437) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1757437 insB 4208483 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689193.1 1756934 R 373384 CDS YP_689194.1 110805674 4208484 1757512..1757739 1 NC_008258.1 IS1 encoded protein 1757739 4208484 SFV_1721 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689194.1 1757512 D 373384 CDS YP_689195.1 110805675 4208485 1757742..1759232 1 NC_008258.1 Code: P; COG: COG3119; sulfatase 1759232 4208485 SFV_1722 Shigella flexneri 5 str. 8401 sulfatase YP_689195.1 1757742 D 373384 CDS YP_689196.1 110805676 4208486 1759284..1760441 1 NC_008258.1 Code: R; COG: COG0641; hypothetical protein 1760441 4208486 SFV_1723 Shigella flexneri 5 str. 8401 hypothetical protein YP_689196.1 1759284 D 373384 CDS YP_689197.1 110805677 4208488 complement(1761931..1762167) 1 NC_008258.1 IS1 encoded protein 1762167 4208488 SFV_1725 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689197.1 1761931 R 373384 CDS YP_689198.1 110805678 4208489 1762242..1762745 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1762745 insB 4208489 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689198.1 1762242 D 373384 CDS YP_689199.1 110805679 4208490 1763232..1765592 1 NC_008258.1 hypothetical protein 1765592 yddB 4208490 yddB Shigella flexneri 5 str. 8401 hypothetical protein YP_689199.1 1763232 D 373384 CDS YP_689200.1 110805680 4208492 1766895..1767398 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1767398 insB 4208492 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689200.1 1766895 D 373384 CDS YP_689201.1 110805681 4208493 1769570..1770970 1 NC_008258.1 Code: E; COG: COG0076; glutamate decarboxylase isozyme 1770970 gadB 4208493 gadB Shigella flexneri 5 str. 8401 glutamate decarboxylase isozyme YP_689201.1 1769570 D 373384 CDS YP_689202.1 110805682 4208494 1771126..1772661 1 NC_008258.1 Code: E; COG: COG0531; acid sensitivity protein transporter 1772661 xasA 4208494 xasA Shigella flexneri 5 str. 8401 acid sensitivity protein transporter YP_689202.1 1771126 D 373384 CDS YP_689203.1 110805683 4208495 1772792..1774111 1 NC_008258.1 Code: S; COG: COG1649; hypothetical protein 1774111 4208495 SFV_1732 Shigella flexneri 5 str. 8401 hypothetical protein YP_689203.1 1772792 D 373384 CDS YP_689204.1 110805684 4208496 1774488..1775633 1 NC_008258.1 hypothetical protein 1775633 4208496 SFV_1733 Shigella flexneri 5 str. 8401 hypothetical protein YP_689204.1 1774488 D 373384 CDS YP_689205.1 110805685 4208497 1775675..1776175 1 NC_008258.1 Code: T; COG: COG2200; hypothetical protein 1776175 4208497 SFV_1734 Shigella flexneri 5 str. 8401 hypothetical protein YP_689205.1 1775675 D 373384 CDS YP_689206.1 110805686 4208402 1776433..1776834 1 NC_008258.1 hypothetical protein 1776834 4208402 SFV_1735 Shigella flexneri 5 str. 8401 hypothetical protein YP_689206.1 1776433 D 373384 CDS YP_689207.1 110805687 4208403 1776779..1777675 1 NC_008258.1 Code: EP; COG: COG1173; ATP-dependent peptide transporter membrane subunit 1777675 4208403 SFV_1736 Shigella flexneri 5 str. 8401 ATP-dependent peptide transporter membrane subunit YP_689207.1 1776779 D 373384 CDS YP_689208.1 110805688 4208404 1777672..1778658 1 NC_008258.1 Code: EP; COG: COG0444; ABC transporter ATP-binding protein 1778658 4208404 SFV_1737 Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_689208.1 1777672 D 373384 CDS YP_689209.1 110805689 4208405 1778651..1779421 1 NC_008258.1 Code: EP; COG: COG1124; ABC transporter ATP-binding protein 1779421 4208405 SFV_1738 Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_689209.1 1778651 D 373384 CDS YP_689210.1 110805690 4208406 complement(1779633..1780064) 1 NC_008258.1 Code: O; COG: COG1764; osmotically inducible protein 1780064 osmC 4208406 osmC Shigella flexneri 5 str. 8401 osmotically inducible protein YP_689210.1 1779633 R 373384 CDS YP_689211.1 110805691 4208407 complement(1780237..1780740) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1780740 insB 4208407 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689211.1 1780237 R 373384 CDS YP_689212.1 110805692 4208408 1780815..1781081 1 NC_008258.1 IS1 encoded protein 1781081 4208408 SFV_1741 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689212.1 1780815 D 373384 CDS YP_689213.1 110805693 4208409 1781122..1782819 1 NC_008258.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1782819 sfcA 4208409 sfcA Shigella flexneri 5 str. 8401 malate dehydrogenase YP_689213.1 1781122 D 373384 CDS YP_689214.1 110805694 4208411 1784047..1784409 1 NC_008258.1 Code: R; COG: COG3093; hypothetical protein 1784409 yddM 4208411 yddM Shigella flexneri 5 str. 8401 hypothetical protein YP_689214.1 1784047 D 373384 CDS YP_689215.1 110805695 4208412 complement(1784637..1785290) 1 NC_008258.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1785290 fdnI 4208412 fdnI Shigella flexneri 5 str. 8401 formate dehydrogenase-N subunit gamma YP_689215.1 1784637 R 373384 CDS YP_689216.1 110805696 4208413 complement(1785283..1786167) 1 NC_008258.1 Code: C; COG: COG0437; formate dehydrogenase-N, nitrate-inducible, iron-sulfur subunit beta 1786167 fdnH 4208413 fdnH Shigella flexneri 5 str. 8401 formate dehydrogenase-N, nitrate-inducible, iron-sulfur subunit beta YP_689216.1 1785283 R 373384 CDS YP_689217.1 110805697 4208414 complement(1786180..1789227) 1 NC_008258.1 Code: C; COG: COG0243; formate dehydrogenase-N, nitrate-inducible subunit alpha 1789227 fdnG 4208414 fdnG Shigella flexneri 5 str. 8401 formate dehydrogenase-N, nitrate-inducible subunit alpha YP_689217.1 1786180 R 373384 CDS YP_689218.1 110805698 4208415 1789516..1790340 1 NC_008258.1 Code: GER; COG: COG0697; hypothetical protein 1790340 yddG 4208415 yddG Shigella flexneri 5 str. 8401 hypothetical protein YP_689218.1 1789516 D 373384 CDS YP_689219.1 110805699 4208416 complement(1790543..1791046) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1791046 insB 4208416 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689219.1 1790543 R 373384 CDS YP_689220.1 110805700 4208417 1791121..1791309 1 NC_008258.1 IS1 encoded protein 1791309 4208417 SFV_1750 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689220.1 1791121 D 373384 CDS YP_689221.1 110805701 4208418 1791372..1792472 1 NC_008258.1 Code: M; COG: COG3203; outer membrane porin protein 1792472 4208418 SFV_1751 Shigella flexneri 5 str. 8401 outer membrane porin protein YP_689221.1 1791372 D 373384 CDS YP_689222.1 110805702 4208419 1792642..1793121 1 NC_008258.1 Code: S; COG: COG4886; hypothetical protein 1793121 4208419 SFV_1752 Shigella flexneri 5 str. 8401 hypothetical protein YP_689222.1 1792642 D 373384 CDS YP_689223.1 110805703 4208420 1793231..1794220 1 NC_008258.1 Code: S; COG: COG4886; glycoprotein 1794220 4208420 SFV_1753 Shigella flexneri 5 str. 8401 glycoprotein YP_689223.1 1793231 D 373384 CDS YP_689224.1 110805704 4208322 complement(1794394..1794627) 1 NC_008258.1 IS1 encoded protein 1794627 4208322 SFV_1754 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689224.1 1794394 R 373384 CDS YP_689225.1 110805705 4208323 1794702..1795205 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1795205 insB 4208323 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689225.1 1794702 D 373384 CDS YP_689226.1 110805706 4208324 1795663..1797051 1 NC_008258.1 Code: P; COG: COG2223; nitrite extrusion protein 2 1797051 narU 4208324 narU Shigella flexneri 5 str. 8401 nitrite extrusion protein 2 YP_689226.1 1795663 D 373384 CDS YP_689227.1 110805707 4208325 1797133..1800873 1 NC_008258.1 Code: C; COG: COG5013; cryptic nitrate reductase 2 subunit alpha 1800873 narZ 4208325 narZ Shigella flexneri 5 str. 8401 cryptic nitrate reductase 2 subunit alpha YP_689227.1 1797133 D 373384 CDS YP_689228.1 110805708 4208326 1800870..1801802 1 NC_008258.1 cryptic nitrate reductase 2 subunit beta 1801802 narY 4208326 narY Shigella flexneri 5 str. 8401 cryptic nitrate reductase 2 subunit beta YP_689228.1 1800870 D 373384 CDS YP_689229.1 110805709 4208327 1801837..1802202 1 NC_008258.1 IS91 ORF2 1802202 4208327 SFV_1759 Shigella flexneri 5 str. 8401 IS91 ORF2 YP_689229.1 1801837 D 373384 CDS YP_689230.1 110805710 4208328 1802316..1803389 1 NC_008258.1 IS91 orf 1803389 4208328 SFV_1760 Shigella flexneri 5 str. 8401 IS91 orf YP_689230.1 1802316 D 373384 CDS YP_689231.1 110805711 4208329 complement(1803660..1804325) 1 NC_008258.1 Code: K; COG: COG1802; DNA-binding transcriptional regulator 1804325 4208329 SFV_1761 Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_689231.1 1803660 R 373384 CDS YP_689232.1 110805712 4208330 complement(1804487..1805590) 1 NC_008258.1 Code: R; COG: COG2130; oxidoreductase 1805590 yncB 4208330 yncB Shigella flexneri 5 str. 8401 oxidoreductase YP_689232.1 1804487 R 373384 CDS YP_689233.2 162139340 4208331 complement(1805720..1806625) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 1806625 4208331 SFV_1763 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_689233.2 1805720 R 373384 CDS YP_689234.1 110805714 4208332 complement(1806583..1806948) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1806948 4208332 SFV_1764 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689234.1 1806583 R 373384 CDS YP_689235.1 110805715 4208334 1807423..1808070 1 NC_008258.1 Code: S; COG: COG3238; hypothetical protein 1808070 4208334 SFV_1766 Shigella flexneri 5 str. 8401 hypothetical protein YP_689235.1 1807423 D 373384 CDS YP_689236.1 110805716 4208335 complement(1808071..1808304) 1 NC_008258.1 hypothetical protein 1808304 4208335 SFV_1767 Shigella flexneri 5 str. 8401 hypothetical protein YP_689236.1 1808071 R 373384 CDS YP_689237.1 110805717 4208336 complement(1808390..1808638) 1 NC_008258.1 hypothetical protein 1808638 4208336 SFV_1768 Shigella flexneri 5 str. 8401 hypothetical protein YP_689237.1 1808390 R 373384 CDS YP_689238.1 110805718 4208337 complement(1809255..1810064) 1 NC_008258.1 acetyltransferase 1810064 4208337 SFV_1769 Shigella flexneri 5 str. 8401 acetyltransferase YP_689238.1 1809255 R 373384 CDS YP_689239.1 110805719 4208338 complement(1810274..1811698) 1 NC_008258.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1811698 4208338 SFV_1770 Shigella flexneri 5 str. 8401 gamma-aminobutyraldehyde dehydrogenase YP_689239.1 1810274 R 373384 CDS YP_689240.1 110805720 4208339 complement(1811720..1812514) 1 NC_008258.1 Code: E; COG: COG1177; transport system permease 1812514 4208339 SFV_1771 Shigella flexneri 5 str. 8401 transport system permease YP_689240.1 1811720 R 373384 CDS YP_689241.1 110805721 4208341 1813194..1814540 1 NC_008258.1 IS91 orf 1814540 4208341 SFV_1773 Shigella flexneri 5 str. 8401 IS91 orf YP_689241.1 1813194 D 373384 CDS YP_689242.1 110805722 4208149 complement(1814629..1815561) 1 NC_008258.1 Code: L; COG: COG0675; virulence protein 1815561 4208149 SFV_1774 Shigella flexneri 5 str. 8401 virulence protein YP_689242.1 1814629 R 373384 CDS YP_689243.1 110805723 4208150 complement(1816153..1816821) 1 NC_008258.1 hypothetical protein 1816821 4208150 SFV_1775 Shigella flexneri 5 str. 8401 hypothetical protein YP_689243.1 1816153 R 373384 CDS YP_689244.1 110805724 4208151 complement(1817124..1817717) 1 NC_008258.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1817717 tehB 4208151 tehB Shigella flexneri 5 str. 8401 tellurite resistance protein TehB YP_689244.1 1817124 R 373384 CDS YP_689245.1 110805725 4208152 complement(1817714..1818706) 1 NC_008258.1 Code: P; COG: COG1275; potassium-tellurite ethidium and proflavin transporter 1818706 tehA 4208152 tehA Shigella flexneri 5 str. 8401 potassium-tellurite ethidium and proflavin transporter YP_689245.1 1817714 R 373384 CDS YP_689246.1 110805726 4208153 1818830..1819810 1 NC_008258.1 hypothetical protein 1819810 4208153 SFV_1778 Shigella flexneri 5 str. 8401 hypothetical protein YP_689246.1 1818830 D 373384 CDS YP_689247.1 110805727 4208154 complement(1819805..1820341) 1 NC_008258.1 Code: J; COG: COG1670; ribosomal-protein-L7/L12-serine acetyltransferase 1820341 rimL 4208154 rimL Shigella flexneri 5 str. 8401 ribosomal-protein-L7/L12-serine acetyltransferase YP_689247.1 1819805 R 373384 CDS YP_689248.1 110805728 4208155 complement(1820404..1820628) 1 NC_008258.1 Code: S; COG: COG2841; hypothetical protein 1820628 ydcH 4208155 ydcH Shigella flexneri 5 str. 8401 hypothetical protein YP_689248.1 1820404 R 373384 CDS YP_689249.1 110805729 4208156 complement(1820768..1822393) 1 NC_008258.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1822393 mdoD 4208156 mdoD Shigella flexneri 5 str. 8401 glucan biosynthesis protein D YP_689249.1 1820768 R 373384 CDS YP_689250.1 110805730 4208157 complement(1822648..1823991) 1 NC_008258.1 Code: S; COG: COG5383; hypothetical protein 1823991 4208157 SFV_1782 Shigella flexneri 5 str. 8401 hypothetical protein YP_689250.1 1822648 R 373384 CDS YP_689251.1 110805731 4208158 1824067..1825131 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 1825131 4208158 SFV_1783 Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_689251.1 1824067 D 373384 CDS YP_689252.1 110805732 4208159 complement(1825169..1826809) 1 NC_008258.1 ribose sensor receptor; Code: NT; COG: COG0840; methyl-accepting chemotaxis protein III, ribose sensor receptor 1826809 trg 4208159 trg Shigella flexneri 5 str. 8401 methyl-accepting chemotaxis protein III, ribose sensor receptor YP_689252.1 1825169 R 373384 CDS YP_689253.1 110805733 4208160 1827185..1827667 1 NC_008258.1 Code: L; COG: COG2963; IS150 ORF1(ORF A) 1827667 4208160 SFV_1785 Shigella flexneri 5 str. 8401 IS150 ORF1(ORF A) YP_689253.1 1827185 D 373384 CDS YP_689254.1 110805734 4208161 complement(1827664..1828377) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1828377 4208161 SFV_1786 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689254.1 1827664 R 373384 CDS YP_689255.1 110805735 4208162 complement(1828518..1828820) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1828820 4208162 SFV_1787 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689255.1 1828518 R 373384 CDS YP_689256.1 110805736 4208163 complement(1829416..1829589) 1 NC_008258.1 hypothetical protein 1829589 ydcA 4208163 ydcA Shigella flexneri 5 str. 8401 hypothetical protein YP_689256.1 1829416 R 373384 CDS YP_689257.2 162139339 4208164 complement(1829834..1830364) 1 NC_008258.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1830364 cybB 4208164 cybB Shigella flexneri 5 str. 8401 cytochrome b561 YP_689257.2 1829834 R 373384 CDS YP_689258.1 110805738 4208165 1830553..1831488 1 NC_008258.1 Code: G; COG: COG0057; glyceraldehyde-3-phosphate dehydrogenase 1831488 gapC 4208165 gapC Shigella flexneri 5 str. 8401 glyceraldehyde-3-phosphate dehydrogenase YP_689258.1 1830553 D 373384 CDS YP_689259.1 110805739 4208166 complement(1831596..1833035) 1 NC_008258.1 NAD-linked; aldehyde dehydrogenase 1833035 aldA 4208166 aldA Shigella flexneri 5 str. 8401 aldehyde dehydrogenase YP_689259.1 1831596 R 373384 CDS YP_689260.1 110805740 4208167 complement(1833340..1833726) 1 NC_008258.1 hypothetical protein 1833726 4208167 SFV_1792 Shigella flexneri 5 str. 8401 hypothetical protein YP_689260.1 1833340 R 373384 CDS YP_689261.1 110805741 4207468 1833827..1834972 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1834972 4207468 SFV_1793 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689261.1 1833827 D 373384 CDS YP_689262.1 110805742 4207469 complement(1835173..1838928) 1 NC_008258.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1838928 hrpA 4207469 hrpA Shigella flexneri 5 str. 8401 ATP-dependent RNA helicase HrpA YP_689262.1 1835173 R 373384 CDS YP_689263.1 110805743 4207470 1839276..1839881 1 NC_008258.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1839881 acpD 4207470 acpD Shigella flexneri 5 str. 8401 azoreductase YP_689263.1 1839276 D 373384 CDS YP_689264.1 110805744 4207471 1840644..1840946 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1840946 4207471 SFV_1796 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689264.1 1840644 D 373384 CDS YP_689265.1 110805745 4207472 1841087..1841800 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1841800 4207472 SFV_1797 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689265.1 1841087 D 373384 CDS YP_689266.1 110805746 4207474 complement(1842502..1844259) 1 NC_008258.1 hypothetical protein 1844259 4207474 SFV_1799 Shigella flexneri 5 str. 8401 hypothetical protein YP_689266.1 1842502 R 373384 CDS YP_689267.1 110805747 4207475 complement(1844275..1844997) 1 NC_008258.1 Code: R; COG: COG4589; phosphatidate cytidiltransferase 1844997 4207475 SFV_1800 Shigella flexneri 5 str. 8401 phosphatidate cytidiltransferase YP_689267.1 1844275 R 373384 CDS YP_689268.1 110805748 4207476 complement(1845170..1845775) 1 NC_008258.1 Code: I; COG: COG0558; hypothetical protein 1845775 4207476 SFV_1801 Shigella flexneri 5 str. 8401 hypothetical protein YP_689268.1 1845170 R 373384 CDS YP_689269.1 110805749 4207477 complement(1845946..1848255) 1 NC_008258.1 hypothetical protein 1848255 ydbD 4207477 ydbD Shigella flexneri 5 str. 8401 hypothetical protein YP_689269.1 1845946 R 373384 CDS YP_689270.1 110805750 4207478 1848369..1848872 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1848872 insB 4207478 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689270.1 1848369 D 373384 CDS YP_689271.1 110805751 4207479 complement(1848866..1849210) 1 NC_008258.1 Code: O; COG: COG3187; heat-inducible protein 1849210 hslJ 4207479 hslJ Shigella flexneri 5 str. 8401 heat-inducible protein YP_689271.1 1848866 R 373384 CDS YP_689272.1 110805752 4207480 complement(1849309..1850298) 1 NC_008258.1 Code: CHR; COG: COG1052; D-lactate dehydrogenase 1850298 ldhA 4207480 ldhA Shigella flexneri 5 str. 8401 D-lactate dehydrogenase YP_689272.1 1849309 R 373384 CDS YP_689273.1 110805753 4207481 1850506..1853145 1 NC_008258.1 hypothetical protein 1853145 ydbH 4207481 ydbH Shigella flexneri 5 str. 8401 hypothetical protein YP_689273.1 1850506 D 373384 CDS YP_689274.1 110805754 4207482 1853142..1853327 1 NC_008258.1 hypothetical protein 1853327 ynbE 4207482 ynbE Shigella flexneri 5 str. 8401 hypothetical protein YP_689274.1 1853142 D 373384 CDS YP_689275.1 110805755 4207483 complement(1854053..1854232) 1 NC_008258.1 IS1 encoded protein 1854232 4207483 SFV_1808 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689275.1 1854053 R 373384 CDS YP_689276.1 110805756 4207484 1854307..1854810 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 1854810 insB 4207484 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689276.1 1854307 D 373384 CDS YP_689277.1 110805757 4207486 1855483..1859007 1 NC_008258.1 oxidoreductase, Fe-S subunit 1859007 ydbK 4207486 ydbK Shigella flexneri 5 str. 8401 oxidoreductase, Fe-S subunit YP_689277.1 1855483 D 373384 CDS YP_689278.1 110805758 4206705 1860572..1861078 1 NC_008258.1 Code: T; COG: COG0589; filament protein 1861078 ynaF 4206705 ynaF Shigella flexneri 5 str. 8401 filament protein YP_689278.1 1860572 D 373384 CDS YP_689279.1 110805759 4206706 1861254..1862189 1 NC_008258.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1862189 ydaO 4206706 ydaO Shigella flexneri 5 str. 8401 C32 tRNA thiolase YP_689279.1 1861254 D 373384 CDS YP_689280.1 110805760 4206707 complement(1862318..1863685) 1 NC_008258.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1863685 dbpA 4206707 dbpA Shigella flexneri 5 str. 8401 ATP-dependent RNA helicase DbpA YP_689280.1 1862318 R 373384 CDS YP_689281.1 110805761 4206708 complement(1864163..1865146) 1 NC_008258.1 Code: P; COG: COG0598; zinc transporter 1865146 zntB 4206708 zntB Shigella flexneri 5 str. 8401 zinc transporter YP_689281.1 1864163 R 373384 CDS YP_689282.1 110805762 4206709 1865401..1866633 1 NC_008258.1 hypothetical protein 1866633 4206709 SFV_1817 Shigella flexneri 5 str. 8401 hypothetical protein YP_689282.1 1865401 D 373384 CDS YP_689283.1 110805763 4206710 complement(1866654..1867217) 1 NC_008258.1 Code: S; COG: COG2840; hypothetical protein 1867217 ydaL 4206710 ydaL Shigella flexneri 5 str. 8401 hypothetical protein YP_689283.1 1866654 R 373384 CDS YP_689284.1 110805764 4206711 complement(1867956..1868924) 1 NC_008258.1 multidrug resistance-like protein 1868924 4206711 SFV_1819 Shigella flexneri 5 str. 8401 multidrug resistance-like protein YP_689284.1 1867956 R 373384 CDS YP_689285.1 110805765 4206712 complement(1868924..1869319) 1 NC_008258.1 secretion protein 1869319 4206712 SFV_1820 Shigella flexneri 5 str. 8401 secretion protein YP_689285.1 1868924 R 373384 CDS YP_689286.1 110805766 4206713 1869630..1870829 1 NC_008258.1 IS1294 orf 1870829 4206713 SFV_1821 Shigella flexneri 5 str. 8401 IS1294 orf YP_689286.1 1869630 D 373384 CDS YP_689287.1 110805767 4206714 complement(1870993..1871640) 1 NC_008258.1 secretion protein 1871640 4206714 SFV_1822 Shigella flexneri 5 str. 8401 secretion protein YP_689287.1 1870993 R 373384 CDS YP_689288.1 110805768 4206715 1871880..1872551 1 NC_008258.1 Code: K; COG: COG2207; hypothetical protein 1872551 4206715 SFV_1823 Shigella flexneri 5 str. 8401 hypothetical protein YP_689288.1 1871880 D 373384 CDS YP_689289.1 110805769 4206716 1873095..1873610 1 NC_008258.1 Code: L; COG: COG0350; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1873610 ogt 4206716 ogt Shigella flexneri 5 str. 8401 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_689289.1 1873095 D 373384 CDS YP_689290.1 110805770 4206717 1873805..1874557 1 NC_008258.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1874557 fnr 4206717 fnr Shigella flexneri 5 str. 8401 fumarate/nitrate reduction transcriptional regulator YP_689290.1 1873805 D 373384 CDS YP_689291.1 110805771 4206718 1874709..1875659 1 NC_008258.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1875659 ydaA 4206718 ydaA Shigella flexneri 5 str. 8401 universal stress protein UspE YP_689291.1 1874709 D 373384 CDS YP_689292.1 110805772 4206719 complement(1875799..1875966) 1 NC_008258.1 hypothetical protein 1875966 ynaJ 4206719 ynaJ Shigella flexneri 5 str. 8401 hypothetical protein YP_689292.1 1875799 R 373384 CDS YP_689293.1 110805773 4206720 complement(1876166..1876732) 1 NC_008258.1 IS911 ORF2 1876732 4206720 SFV_1828 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_689293.1 1876166 R 373384 CDS YP_689294.1 110805774 4206721 complement(1877033..1877335) 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 1877335 4206721 SFV_1829 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_689294.1 1877033 R 373384 CDS YP_689295.1 110805775 4206722 1877463..1878494 1 NC_008258.1 Code: M; COG: COG0668; hypothetical protein 1878494 4206722 SFV_1830 Shigella flexneri 5 str. 8401 hypothetical protein YP_689295.1 1877463 D 373384 CDS YP_689296.1 110805776 4206723 complement(1878545..1880179) 1 NC_008258.1 Code: E; COG: COG4166; transport periplasmic protein 1880179 4206723 SFV_1831 Shigella flexneri 5 str. 8401 transport periplasmic protein YP_689296.1 1878545 R 373384 CDS YP_689297.1 110805777 4206821 1881026..1881328 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1881328 4206821 SFV_1833 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689297.1 1881026 D 373384 CDS YP_689298.1 110805778 4206822 1881469..1882182 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1882182 4206822 SFV_1834 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689298.1 1881469 D 373384 CDS YP_689299.1 110805779 4206824 1883130..1883402 1 NC_008258.1 host-nuclease inhibitor protein Gam 1883402 4206824 SFV_1836 Shigella flexneri 5 str. 8401 host-nuclease inhibitor protein Gam YP_689299.1 1883130 D 373384 CDS YP_689300.1 110805780 4206825 1883486..1884529 1 NC_008258.1 bacteriophage protein 1884529 4206825 SFV_1837 Shigella flexneri 5 str. 8401 bacteriophage protein YP_689300.1 1883486 D 373384 CDS YP_689301.1 110805781 4206826 1884869..1885171 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1885171 4206826 SFV_1838 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689301.1 1884869 D 373384 CDS YP_689302.1 110805782 4206827 1885312..1886025 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1886025 4206827 SFV_1839 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689302.1 1885312 D 373384 CDS YP_689303.1 110805783 4206828 1886389..1887465 1 NC_008258.1 Code: L; COG: COG0582; phage integrase 1887465 4206828 SFV_1840 Shigella flexneri 5 str. 8401 phage integrase YP_689303.1 1886389 D 373384 CDS YP_689304.1 110805784 4206829 complement(1887858..1888199) 1 NC_008258.1 hypothetical protein 1888199 4206829 SFV_1841 Shigella flexneri 5 str. 8401 hypothetical protein YP_689304.1 1887858 R 373384 CDS YP_689305.1 110805785 4206830 complement(1888212..1889084) 1 NC_008258.1 Code: P; COG: COG1276; resistance protein 1889084 4206830 SFV_1842 Shigella flexneri 5 str. 8401 resistance protein YP_689305.1 1888212 R 373384 CDS YP_689306.1 110805786 4206831 complement(1889088..1889462) 1 NC_008258.1 Code: R; COG: COG2372; hypothetical protein 1889462 4206831 SFV_1843 Shigella flexneri 5 str. 8401 hypothetical protein YP_689306.1 1889088 R 373384 CDS YP_689307.1 110805787 4206832 1889601..1889831 1 NC_008258.1 DNA polymerase III subunit theta 1889831 holE 4206832 holE Shigella flexneri 5 str. 8401 DNA polymerase III subunit theta YP_689307.1 1889601 D 373384 CDS YP_689308.1 110805788 4206833 1890164..1890589 1 NC_008258.1 Code: R; COG: COG0388; hypothetical protein 1890589 4206833 SFV_1845 Shigella flexneri 5 str. 8401 hypothetical protein YP_689308.1 1890164 D 373384 CDS YP_689309.1 110805789 4206834 1890613..1891275 1 NC_008258.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 1891275 4206834 SFV_1846 Shigella flexneri 5 str. 8401 exodeoxyribonuclease X YP_689309.1 1890613 D 373384 CDS YP_689310.1 110805790 4206835 complement(1891272..1893332) 1 NC_008258.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 1893332 ptrB 4206835 ptrB Shigella flexneri 5 str. 8401 protease 2 YP_689310.1 1891272 R 373384 CDS YP_689311.1 110805791 4206836 complement(1893541..1894200) 1 NC_008258.1 Code: S; COG: COG2979; hypothetical protein 1894200 yebE 4206836 yebE Shigella flexneri 5 str. 8401 hypothetical protein YP_689311.1 1893541 R 373384 CDS YP_689312.1 110805792 4206837 complement(1894527..1894895) 1 NC_008258.1 secreted protein; unknown function; hypothetical protein 1894895 yebF 4206837 yebF Shigella flexneri 5 str. 8401 hypothetical protein YP_689312.1 1894527 R 373384 CDS YP_689313.1 110805793 4206839 1895374..1896552 1 NC_008258.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1896552 purT 4206839 purT Shigella flexneri 5 str. 8401 phosphoribosylglycinamide formyltransferase 2 YP_689313.1 1895374 D 373384 CDS YP_689314.1 110805794 4208653 complement(1896608..1897249) 1 NC_008258.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1897249 eda 4208653 eda Shigella flexneri 5 str. 8401 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_689314.1 1896608 R 373384 CDS YP_689315.1 110805795 4208654 complement(1897286..1899097) 1 NC_008258.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 1899097 edd 4208654 edd Shigella flexneri 5 str. 8401 phosphogluconate dehydratase YP_689315.1 1897286 R 373384 CDS YP_689316.1 110805796 4208655 complement(1899332..1900807) 1 NC_008258.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1900807 zwf 4208655 zwf Shigella flexneri 5 str. 8401 glucose-6-phosphate 1-dehydrogenase YP_689316.1 1899332 R 373384 CDS YP_689317.1 110805797 4208656 1901144..1902013 1 NC_008258.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 1902013 yebK 4208656 yebK Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator HexR YP_689317.1 1901144 D 373384 CDS YP_689318.1 110805798 4208657 1902141..1903583 1 NC_008258.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1903583 pykA 4208657 pykA Shigella flexneri 5 str. 8401 pyruvate kinase YP_689318.1 1902141 D 373384 CDS YP_689319.1 110805799 4208658 complement(1903714..1904739) 1 NC_008258.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 1904739 msbB 4208658 msbB Shigella flexneri 5 str. 8401 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_689319.1 1903714 R 373384 CDS YP_689320.1 110805800 4208659 complement(1904805..1906127) 1 NC_008258.1 Code: M; COG: COG0739; hypothetical protein 1906127 yebA 4208659 yebA Shigella flexneri 5 str. 8401 hypothetical protein YP_689320.1 1904805 R 373384 CDS YP_689321.1 110805802 4208661 complement(1906143..1907201) 1 NC_008258.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic component 1907201 znuA 4208661 znuA Shigella flexneri 5 str. 8401 high-affinity zinc transporter periplasmic component YP_689321.1 1906143 R 373384 CDS YP_689322.1 110805801 4208660 1907154..1907909 1 NC_008258.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 1907909 znuC 4208660 znuC Shigella flexneri 5 str. 8401 high-affinity zinc transporter ATPase YP_689322.1 1907154 D 373384 CDS YP_689323.1 110805803 4208662 1907906..1908691 1 NC_008258.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane component 1908691 znuB 4208662 znuB Shigella flexneri 5 str. 8401 high-affinity zinc transporter membrane component YP_689323.1 1907906 D 373384 CDS YP_689324.1 110805804 4208663 complement(1908838..1909848) 1 NC_008258.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1909848 ruvB 4208663 ruvB Shigella flexneri 5 str. 8401 Holliday junction DNA helicase RuvB YP_689324.1 1908838 R 373384 CDS YP_689325.1 110805805 4208664 complement(1909857..1910468) 1 NC_008258.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1910468 ruvA 4208664 ruvA Shigella flexneri 5 str. 8401 Holliday junction DNA helicase RuvA YP_689325.1 1909857 R 373384 CDS YP_689326.1 110805806 4208665 1910742..1911344 1 NC_008258.1 hypothetical protein 1911344 yebB 4208665 yebB Shigella flexneri 5 str. 8401 hypothetical protein YP_689326.1 1910742 D 373384 CDS YP_689327.1 110805807 4208666 complement(1911346..1911867) 1 NC_008258.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1911867 ruvC 4208666 ruvC Shigella flexneri 5 str. 8401 Holliday junction resolvase YP_689327.1 1911346 R 373384 CDS YP_689328.1 110805808 4208667 complement(1911902..1912642) 1 NC_008258.1 Code: S; COG: COG0217; hypothetical protein 1912642 yebC 4208667 yebC Shigella flexneri 5 str. 8401 hypothetical protein YP_689328.1 1911902 R 373384 CDS YP_689329.1 110805809 4208668 complement(1912671..1913153) 1 NC_008258.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1913153 ntpA 4208668 ntpA Shigella flexneri 5 str. 8401 dATP pyrophosphohydrolase YP_689329.1 1912671 R 373384 CDS YP_689330.1 110805810 4208669 complement(1913241..1915013) 1 NC_008258.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1915013 aspS 4208669 aspS Shigella flexneri 5 str. 8401 aspartyl-tRNA synthetase YP_689330.1 1913241 R 373384 CDS YP_689331.1 110805811 4208671 1915769..1916965 1 NC_008258.1 Code: L; COG: COG3547; ISSfl2 ORF 1916965 4208671 SFV_1870 Shigella flexneri 5 str. 8401 ISSfl2 ORF YP_689331.1 1915769 D 373384 CDS YP_689332.1 110805812 4207005 1917694..1917942 1 NC_008258.1 hypothetical protein 1917942 4207005 SFV_1871 Shigella flexneri 5 str. 8401 hypothetical protein YP_689332.1 1917694 D 373384 CDS YP_689333.1 110805813 4207006 1918541..1920292 1 NC_008258.1 Code: S; COG: COG4886; invasion plasmid antigen 1920292 ipaH_3 4207006 ipaH_3 Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_689333.1 1918541 D 373384 CDS YP_689334.1 110805814 4207007 complement(1920472..1922460) 1 NC_008258.1 phage tail fiber protein 1922460 4207007 SFV_1873 Shigella flexneri 5 str. 8401 phage tail fiber protein YP_689334.1 1920472 R 373384 CDS YP_689335.1 110805815 4207008 complement(1922524..1923123) 1 NC_008258.1 Code: M; COG: COG3637; hypothetical protein 1923123 4207008 SFV_1874 Shigella flexneri 5 str. 8401 hypothetical protein YP_689335.1 1922524 R 373384 CDS YP_689336.1 110805816 4207009 complement(1923191..1926670) 1 NC_008258.1 Code: S; COG: COG4733; host specificity protein 1926670 4207009 SFV_1875 Shigella flexneri 5 str. 8401 host specificity protein YP_689336.1 1923191 R 373384 CDS YP_689337.1 110805817 4207010 complement(1926731..1927306) 1 NC_008258.1 Code: S; COG: COG4723; tail component of prophage 1927306 4207010 SFV_1876 Shigella flexneri 5 str. 8401 tail component of prophage YP_689337.1 1926731 R 373384 CDS YP_689338.1 110805818 4207011 complement(1927270..1928082) 1 NC_008258.1 tail assembly protein 1928082 4207011 SFV_1877 Shigella flexneri 5 str. 8401 tail assembly protein YP_689338.1 1927270 R 373384 CDS YP_689339.1 110805819 4207012 complement(1928018..1928959) 1 NC_008258.1 Code: S; COG: COG4672; minor tail protein 1928959 4207012 SFV_1878 Shigella flexneri 5 str. 8401 minor tail protein YP_689339.1 1928018 R 373384 CDS YP_689340.1 110805820 4207014 complement(1931973..1932302) 1 NC_008258.1 tail component of prophage 1932302 4207014 SFV_1880 Shigella flexneri 5 str. 8401 tail component of prophage YP_689340.1 1931973 R 373384 CDS YP_689341.1 110805821 4207015 complement(1932311..1932697) 1 NC_008258.1 tail component of prophage 1932697 4207015 SFV_1881 Shigella flexneri 5 str. 8401 tail component of prophage YP_689341.1 1932311 R 373384 CDS YP_689342.1 110805822 4207016 complement(1932756..1933496) 1 NC_008258.1 Code: N; COG: COG5492; tail component of prophage 1933496 4207016 SFV_1882 Shigella flexneri 5 str. 8401 tail component of prophage YP_689342.1 1932756 R 373384 CDS YP_689343.1 110805823 4207017 complement(1933507..1933908) 1 NC_008258.1 tail component of prophage 1933908 4207017 SFV_1883 Shigella flexneri 5 str. 8401 tail component of prophage YP_689343.1 1933507 R 373384 CDS YP_689344.1 110805824 4207018 complement(1933905..1934441) 1 NC_008258.1 tail component of prophage 1934441 4207018 SFV_1884 Shigella flexneri 5 str. 8401 tail component of prophage YP_689344.1 1933905 R 373384 CDS YP_689345.1 110805825 4207019 complement(1934479..1934850) 1 NC_008258.1 tail attachment protein 1934850 4207019 SFV_1885 Shigella flexneri 5 str. 8401 tail attachment protein YP_689345.1 1934479 R 373384 CDS YP_689346.1 110805826 4207020 complement(1934862..1935263) 1 NC_008258.1 DNA-packaging protein 1935263 4207020 SFV_1886 Shigella flexneri 5 str. 8401 DNA-packaging protein YP_689346.1 1934862 R 373384 CDS YP_689347.1 110805827 4207021 1935527..1936723 1 NC_008258.1 Code: L; COG: COG3547; ISSfl2 ORF 1936723 4207021 SFV_1887 Shigella flexneri 5 str. 8401 ISSfl2 ORF YP_689347.1 1935527 D 373384 CDS YP_689348.1 110805828 4207438 complement(1937908..1938492) 1 NC_008258.1 Q antiterminator encoded by prophage 1938492 4207438 SFV_1892 Shigella flexneri 5 str. 8401 Q antiterminator encoded by prophage YP_689348.1 1937908 R 373384 CDS YP_689349.1 110805829 4207439 complement(1938594..1938953) 1 NC_008258.1 Code: L; COG: COG4570; endonuclease encoded by cryptic prophage 1938953 4207439 SFV_1893 Shigella flexneri 5 str. 8401 endonuclease encoded by cryptic prophage YP_689349.1 1938594 R 373384 CDS YP_689350.1 110805830 4207440 complement(1938953..1939141) 1 NC_008258.1 bacteriophage protein 1939141 4207440 SFV_1894 Shigella flexneri 5 str. 8401 bacteriophage protein YP_689350.1 1938953 R 373384 CDS YP_689351.1 110805831 4207441 1939157..1939459 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 1939459 4207441 SFV_1895 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689351.1 1939157 D 373384 CDS YP_689352.1 110805832 4207442 1939600..1940313 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1940313 4207442 SFV_1896 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689352.1 1939600 D 373384 CDS YP_689353.1 110805833 4207443 complement(1940354..1941046) 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 1941046 4207443 SFV_1897 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_689353.1 1940354 R 373384 CDS YP_689354.1 110805834 4207444 complement(1941046..1941372) 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 1941372 4207444 SFV_1898 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_689354.1 1941046 R 373384 CDS YP_689355.1 110805835 4207445 complement(1941424..1942197) 1 NC_008258.1 hypothetical protein 1942197 4207445 SFV_1899 Shigella flexneri 5 str. 8401 hypothetical protein YP_689355.1 1941424 R 373384 CDS YP_689356.1 110805836 4207446 complement(1942294..1943988) 1 NC_008258.1 hypothetical protein 1943988 4207446 SFV_1900 Shigella flexneri 5 str. 8401 hypothetical protein YP_689356.1 1942294 R 373384 CDS YP_689357.1 110805837 4207447 complement(1945144..1945515) 1 NC_008258.1 hypothetical protein 1945515 4207447 SFV_1901 Shigella flexneri 5 str. 8401 hypothetical protein YP_689357.1 1945144 R 373384 CDS YP_689358.1 110805838 4207448 complement(1947315..1947869) 1 NC_008258.1 hypothetical protein 1947869 4207448 SFV_1902 Shigella flexneri 5 str. 8401 hypothetical protein YP_689358.1 1947315 R 373384 CDS YP_689359.1 110805839 4207449 complement(1950212..1951045) 1 NC_008258.1 hypothetical protein 1951045 4207449 SFV_1903 Shigella flexneri 5 str. 8401 hypothetical protein YP_689359.1 1950212 R 373384 CDS YP_689360.1 110805840 4207450 1951136..1951486 1 NC_008258.1 hypothetical protein 1951486 4207450 SFV_1904 Shigella flexneri 5 str. 8401 hypothetical protein YP_689360.1 1951136 D 373384 CDS YP_689361.1 110805841 4207451 1951539..1951934 1 NC_008258.1 Code: R; COG: COG3788; hypothetical protein 1951934 yecN 4207451 yecN Shigella flexneri 5 str. 8401 hypothetical protein YP_689361.1 1951539 D 373384 CDS YP_689362.1 110805842 4206951 1951975..1952718 1 NC_008258.1 Code: QR; COG: COG0500; hypothetical protein 1952718 yecO 4206951 yecO Shigella flexneri 5 str. 8401 hypothetical protein YP_689362.1 1951975 D 373384 CDS YP_689363.1 110805843 4206952 1952715..1953686 1 NC_008258.1 Code: QR; COG: COG0500; hypothetical protein 1953686 yecP 4206952 yecP Shigella flexneri 5 str. 8401 hypothetical protein YP_689363.1 1952715 D 373384 CDS YP_689364.1 110805844 4206953 1955058..1955423 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 1955423 4206953 SFV_1908 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689364.1 1955058 D 373384 CDS YP_689365.1 110805845 4206954 1955447..1956286 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 1956286 4206954 SFV_1909 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_689365.1 1955447 D 373384 CDS YP_689366.1 110805846 4206956 complement(1957641..1958741) 1 NC_008258.1 Code: C; COG: COG3005; cytochrome C-type protein 1958741 yecK 4206956 yecK Shigella flexneri 5 str. 8401 cytochrome C-type protein YP_689366.1 1957641 R 373384 CDS YP_689367.1 110805847 4206957 complement(1959129..1959875) 1 NC_008258.1 Code: P; COG: COG3142; copper homeostasis protein CutC 1959875 cutC 4206957 cutC Shigella flexneri 5 str. 8401 copper homeostasis protein CutC YP_689367.1 1959129 R 373384 CDS YP_689368.1 110805848 4206958 complement(1959889..1960455) 1 NC_008258.1 Code: S; COG: COG3102; hypothetical protein 1960455 yecM 4206958 yecM Shigella flexneri 5 str. 8401 hypothetical protein YP_689368.1 1959889 R 373384 CDS YP_689369.1 110805849 4206959 1960671..1962404 1 NC_008258.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1962404 argS 4206959 argS Shigella flexneri 5 str. 8401 arginyl-tRNA synthetase YP_689369.1 1960671 D 373384 CDS YP_689370.1 110805850 4206960 1962581..1963069 1 NC_008258.1 Code: S; COG: COG3755; hypothetical protein 1963069 yecT 4206960 yecT Shigella flexneri 5 str. 8401 hypothetical protein YP_689370.1 1962581 D 373384 CDS YP_689371.1 110805851 4206961 complement(1963289..1963723) 1 NC_008258.1 IS629 ORF2 1963723 4206961 SFV_1916 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_689371.1 1963289 R 373384 CDS YP_689372.1 110805852 4206962 complement(1963805..1964158) 1 NC_008258.1 IS629 ORF2 1964158 4206962 SFV_1917 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_689372.1 1963805 R 373384 CDS YP_689373.1 110805853 4206963 complement(1964158..1964484) 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 1964484 4206963 SFV_1918 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_689373.1 1964158 R 373384 CDS YP_689374.1 110805854 4206964 complement(1964536..1964874) 1 NC_008258.1 flagellar protein 1964874 flhE 4206964 flhE Shigella flexneri 5 str. 8401 flagellar protein YP_689374.1 1964536 R 373384 CDS YP_689375.2 162139338 4206966 complement(1966898..1968091) 1 NC_008258.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 1968091 flhB 4206966 flhB Shigella flexneri 5 str. 8401 flagellar biosynthesis protein FlhB YP_689375.2 1966898 R 373384 CDS YP_689376.1 110805856 4206967 complement(1968720..1969286) 1 NC_008258.1 IS911 ORF2 1969286 4206967 SFV_1922 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_689376.1 1968720 R 373384 CDS YP_689377.1 110805857 4206968 complement(1969587..1969925) 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 1969925 4206968 SFV_1923 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_689377.1 1969587 R 373384 CDS YP_689378.1 110805858 4206969 1970030..1970425 1 NC_008258.1 hypothetical protein 1970425 4206969 SFV_1924 Shigella flexneri 5 str. 8401 hypothetical protein YP_689378.1 1970030 D 373384 CDS YP_689379.1 110805859 4206970 1970654..1970779 1 NC_008258.1 IS600 ORF1 1970779 4206970 SFV_1925 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689379.1 1970654 D 373384 CDS YP_689380.1 110805860 4208875 1970920..1971633 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 1971633 4208875 SFV_1926 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689380.1 1970920 D 373384 CDS YP_689381.1 110805861 4208876 complement(1972137..1972781) 1 NC_008258.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 1972781 cheZ 4208876 cheZ Shigella flexneri 5 str. 8401 chemotaxis regulator CheZ YP_689381.1 1972137 R 373384 CDS YP_689382.1 110805862 4208877 complement(1972792..1973181) 1 NC_008258.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 1973181 cheY 4208877 cheY Shigella flexneri 5 str. 8401 chemotaxis regulatory protein CheY YP_689382.1 1972792 R 373384 CDS YP_689383.1 110805863 4208878 complement(1973196..1974245) 1 NC_008258.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 1974245 cheB 4208878 cheB Shigella flexneri 5 str. 8401 chemotaxis-specific methylesterase YP_689383.1 1973196 R 373384 CDS YP_689384.1 110805864 4208879 complement(1974248..1975108) 1 NC_008258.1 methylates the MCP; chemotaxis methyltransferase CheR 1975108 cheR 4208879 cheR Shigella flexneri 5 str. 8401 chemotaxis methyltransferase CheR YP_689384.1 1974248 R 373384 CDS YP_689385.1 110805865 4208880 complement(1975127..1976728) 1 NC_008258.1 mediates taxis toward dipeptides; methyl-accepting protein IV 1976728 tap 4208880 tap Shigella flexneri 5 str. 8401 methyl-accepting protein IV YP_689385.1 1975127 R 373384 CDS YP_689386.1 110805866 4208881 complement(1976774..1978435) 1 NC_008258.1 Code: NT; COG: COG0840; methyl-accepting chemotaxis protein II, aspartate sensor receptor 1978435 tar 4208881 tar Shigella flexneri 5 str. 8401 methyl-accepting chemotaxis protein II, aspartate sensor receptor YP_689386.1 1976774 R 373384 CDS YP_689387.1 110805867 4208882 complement(1978580..1979083) 1 NC_008258.1 Code: NT; COG: COG0835; purine-binding chemotaxis protein 1979083 cheW 4208882 cheW Shigella flexneri 5 str. 8401 purine-binding chemotaxis protein YP_689387.1 1978580 R 373384 CDS YP_689388.1 110805868 4208883 complement(1979104..1981068) 1 NC_008258.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 1981068 cheA 4208883 cheA Shigella flexneri 5 str. 8401 chemotaxis protein CheA YP_689388.1 1979104 R 373384 CDS YP_689389.1 110805869 4208884 complement(1981073..1981999) 1 NC_008258.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 1981999 motB 4208884 motB Shigella flexneri 5 str. 8401 flagellar motor protein MotB YP_689389.1 1981073 R 373384 CDS YP_689390.1 110805870 4208885 complement(1981996..1982883) 1 NC_008258.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 1982883 motA 4208885 motA Shigella flexneri 5 str. 8401 flagellar motor protein MotA YP_689390.1 1981996 R 373384 CDS YP_689391.1 110805871 4208886 complement(1983010..1983588) 1 NC_008258.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 1983588 flhC 4208886 flhC Shigella flexneri 5 str. 8401 transcriptional activator FlhC YP_689391.1 1983010 R 373384 CDS YP_689392.1 110805872 4208888 1984724..1985152 1 NC_008258.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 1985152 yecG 4208888 yecG Shigella flexneri 5 str. 8401 universal stress protein UspC YP_689392.1 1984724 D 373384 CDS YP_689393.1 110805873 4208890 complement(1986548..1987348) 1 NC_008258.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 1987348 otsB 4208890 otsB Shigella flexneri 5 str. 8401 trehalose-6-phosphate phosphatase YP_689393.1 1986548 R 373384 CDS YP_689394.1 110805874 4208891 complement(1987515..1988501) 1 NC_008258.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 1988501 araH 4208891 araH Shigella flexneri 5 str. 8401 L-arabinose transporter permease YP_689394.1 1987515 R 373384 CDS YP_689395.1 110805875 4208892 complement(1989144..1990025) 1 NC_008258.1 L-arabinose transport ATP-binding protein araG 1990025 araG 4208892 araG Shigella flexneri 5 str. 8401 L-arabinose transport ATP-binding protein araG YP_689395.1 1989144 R 373384 CDS YP_689396.1 110805876 4208893 complement(1990095..1991084) 1 NC_008258.1 Code: G; COG: COG1879; L-arabinose-binding periplasmic protein 1991084 araF 4208893 araF Shigella flexneri 5 str. 8401 L-arabinose-binding periplasmic protein YP_689396.1 1990095 R 373384 CDS YP_689397.1 110805877 4207452 1991881..1992384 1 NC_008258.1 Code: P; COG: COG1528; ferritin 1992384 yecI 4207452 yecI Shigella flexneri 5 str. 8401 ferritin YP_689397.1 1991881 D 373384 CDS YP_689399.1 110805879 4207454 complement(1992464..1992715) 1 NC_008258.1 hypothetical protein 1992715 4207454 SFV_1947 Shigella flexneri 5 str. 8401 hypothetical protein YP_689399.1 1992464 R 373384 CDS YP_689400.1 110805880 4207455 1993179..1993502 1 NC_008258.1 hypothetical protein 1993502 4207455 SFV_1948 Shigella flexneri 5 str. 8401 hypothetical protein YP_689400.1 1993179 D 373384 CDS YP_689401.1 110805881 4207456 1993673..1994170 1 NC_008258.1 cytoplasmic iron storage protein; ferritin 1994170 ftn 4207456 ftn Shigella flexneri 5 str. 8401 ferritin YP_689401.1 1993673 D 373384 CDS YP_689402.1 110805882 4207457 complement(1994207..1994446) 1 NC_008258.1 hypothetical protein 1994446 yecH 4207457 yecH Shigella flexneri 5 str. 8401 hypothetical protein YP_689402.1 1994207 R 373384 CDS YP_689403.1 110805883 4207458 1994636..1995847 1 NC_008258.1 Code: E; COG: COG0814; tyrosine transporter 1995847 tyrP 4207458 tyrP Shigella flexneri 5 str. 8401 tyrosine transporter YP_689403.1 1994636 D 373384 CDS YP_689404.1 110805884 4207459 complement(1995909..1996574) 1 NC_008258.1 Code: R; COG: COG3318; hypothetical protein 1996574 yecA 4207459 yecA Shigella flexneri 5 str. 8401 hypothetical protein YP_689404.1 1995909 R 373384 CDS YP_689405.1 110805885 4207463 complement(1997224..1997772) 1 NC_008258.1 Code: I; COG: COG0558; phosphatidylglycerophosphate synthetase 1997772 pgsA 4207463 pgsA Shigella flexneri 5 str. 8401 phosphatidylglycerophosphate synthetase YP_689405.1 1997224 R 373384 CDS YP_689406.1 110805886 4207464 complement(1997829..1999595) 1 NC_008258.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1999595 uvrC 4207464 uvrC Shigella flexneri 5 str. 8401 excinuclease ABC subunit C YP_689406.1 1997829 R 373384 CDS YP_689407.1 110805887 4207465 complement(1999658..2000278) 1 NC_008258.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 2000278 uvrY 4207465 uvrY Shigella flexneri 5 str. 8401 response regulator YP_689407.1 1999658 R 373384 CDS YP_689408.1 110805888 4207466 2000773..2000997 1 NC_008258.1 hypothetical protein 2000997 yecF 4207466 yecF Shigella flexneri 5 str. 8401 hypothetical protein YP_689408.1 2000773 D 373384 CDS YP_689409.1 110805889 4207467 complement(2001024..2001650) 1 NC_008258.1 Code: K; COG: COG2771; cell division protein FtsQ 2001650 sdiA 4207467 sdiA Shigella flexneri 5 str. 8401 cell division protein FtsQ YP_689409.1 2001024 R 373384 CDS YP_689410.1 110805890 4207488 complement(2001880..2002632) 1 NC_008258.1 Code: E; COG: COG1126; amino-acid ABC transporter ATP-binding protein YecC 2002632 yecC 4207488 yecC Shigella flexneri 5 str. 8401 amino-acid ABC transporter ATP-binding protein YecC YP_689410.1 2001880 R 373384 CDS YP_689411.1 110805891 4207489 complement(2002629..2003297) 1 NC_008258.1 Code: E; COG: COG0765; transport system permease 2003297 yecS 4207489 yecS Shigella flexneri 5 str. 8401 transport system permease YP_689411.1 2002629 R 373384 CDS YP_689412.1 110805892 4207490 complement(2003312..2004298) 1 NC_008258.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 2004298 yedO 4207490 yedO Shigella flexneri 5 str. 8401 D-cysteine desulfhydrase YP_689412.1 2003312 R 373384 CDS YP_689413.1 110805893 4207491 complement(2004403..2005203) 1 NC_008258.1 Code: ET; COG: COG0834; cystine transporter subunit 2005203 fliY 4207491 fliY Shigella flexneri 5 str. 8401 cystine transporter subunit YP_689413.1 2004403 R 373384 CDS YP_689414.1 110805894 4207492 complement(2005291..2005842) 1 NC_008258.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 2005842 fliZ 4207492 fliZ Shigella flexneri 5 str. 8401 flagella biosynthesis protein FliZ YP_689414.1 2005291 R 373384 CDS YP_689415.1 110805895 4207493 complement(2005888..2006577) 1 NC_008258.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 2006577 fliA 4207493 fliA Shigella flexneri 5 str. 8401 flagellar biosynthesis sigma factor YP_689415.1 2005888 R 373384 CDS YP_689416.1 110805896 4207494 complement(2006772..2008424) 1 NC_008258.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes; flagellin 2008424 fliC 4207494 fliC Shigella flexneri 5 str. 8401 flagellin YP_689416.1 2006772 R 373384 CDS YP_689417.1 110805897 4207495 2008690..2010096 1 NC_008258.1 involved in flagellin assembly; flagellar capping protein 2010096 fliD 4207495 fliD Shigella flexneri 5 str. 8401 flagellar capping protein YP_689417.1 2008690 D 373384 CDS YP_689418.1 110805898 4207496 2010121..2010531 1 NC_008258.1 flagellin specific chaperone; flagellar protein FliS 2010531 fliS 4207496 fliS Shigella flexneri 5 str. 8401 flagellar protein FliS YP_689418.1 2010121 D 373384 CDS YP_689419.1 110805899 4207497 2010531..2010896 1 NC_008258.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2010896 fliT 4207497 fliT Shigella flexneri 5 str. 8401 flagellar biosynthesis protein FliT YP_689419.1 2010531 D 373384 CDS YP_689420.1 110805900 4207498 2010974..2012461 1 NC_008258.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 2012461 amyA 4207498 amyA Shigella flexneri 5 str. 8401 cytoplasmic alpha-amylase YP_689420.1 2010974 D 373384 CDS YP_689421.1 110805901 4207499 complement(2012495..2012878) 1 NC_008258.1 hypothetical protein 2012878 yedD 4207499 yedD Shigella flexneri 5 str. 8401 hypothetical protein YP_689421.1 2012495 R 373384 CDS YP_689422.1 110805902 4207500 2013095..2014300 1 NC_008258.1 Code: R; COG: COG2391; inner membrane protein 2014300 yedE 4207500 yedE Shigella flexneri 5 str. 8401 inner membrane protein YP_689422.1 2013095 D 373384 CDS YP_689423.1 110805903 4207501 2014297..2014530 1 NC_008258.1 Code: O; COG: COG0425; hypothetical protein 2014530 yedF 4207501 yedF Shigella flexneri 5 str. 8401 hypothetical protein YP_689423.1 2014297 D 373384 CDS YP_689424.1 110805904 4207503 complement(2015347..2016153) 1 NC_008258.1 Code: L; COG: COG0675; virulence protein 2016153 4207503 SFV_1976 Shigella flexneri 5 str. 8401 virulence protein YP_689424.1 2015347 R 373384 CDS YP_689425.1 110805905 4207504 2017566..2018648 1 NC_008258.1 Code: M; COG: COG3203; porin 2018648 nmpC 4207504 nmpC Shigella flexneri 5 str. 8401 porin YP_689425.1 2017566 D 373384 CDS YP_689426.1 110805906 4207505 complement(2019137..2019934) 1 NC_008258.1 Code: K; COG: COG2207; regulator 2019934 ybcM 4207505 ybcM Shigella flexneri 5 str. 8401 regulator YP_689426.1 2019137 R 373384 CDS YP_689427.1 110805907 4207506 complement(2020664..2021161) 1 NC_008258.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 2021161 emrE 4207506 emrE Shigella flexneri 5 str. 8401 multidrug efflux protein YP_689427.1 2020664 R 373384 CDS YP_689428.1 110805908 4207507 complement(2021341..2021655) 1 NC_008258.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2021655 fliE 4207507 fliE Shigella flexneri 5 str. 8401 flagellar hook-basal body protein FliE YP_689428.1 2021341 R 373384 CDS YP_689429.1 110805909 4207118 2023592..2024515 1 NC_008258.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2024515 fliG 4207118 fliG Shigella flexneri 5 str. 8401 flagellar motor switch protein G YP_689429.1 2023592 D 373384 CDS YP_689430.1 110805910 4207119 2024508..2025194 1 NC_008258.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2025194 fliH 4207119 fliH Shigella flexneri 5 str. 8401 flagellar assembly protein H YP_689430.1 2024508 D 373384 CDS YP_689431.1 110805911 4207120 2025194..2026567 1 NC_008258.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2026567 fliI 4207120 fliI Shigella flexneri 5 str. 8401 flagellum-specific ATP synthase YP_689431.1 2025194 D 373384 CDS YP_689432.1 110805912 4207122 2026927..2028054 1 NC_008258.1 Code: N; COG: COG3144; flagellar hook-length control protein 2028054 fliK 4207122 fliK Shigella flexneri 5 str. 8401 flagellar hook-length control protein YP_689432.1 2026927 D 373384 CDS YP_689433.1 110805913 4207123 2028159..2028623 1 NC_008258.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body protein FliL 2028623 fliL 4207123 fliL Shigella flexneri 5 str. 8401 flagellar basal body protein FliL YP_689433.1 2028159 D 373384 CDS YP_689434.1 110805914 4207124 2028583..2029632 1 NC_008258.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2029632 fliM 4207124 fliM Shigella flexneri 5 str. 8401 flagellar motor switch protein FliM YP_689434.1 2028583 D 373384 CDS YP_689435.1 110805915 4207125 2029629..2030042 1 NC_008258.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2030042 fliN 4207125 fliN Shigella flexneri 5 str. 8401 flagellar motor switch protein FliN YP_689435.1 2029629 D 373384 CDS YP_689436.1 110805916 4207126 2030045..2030410 1 NC_008258.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2030410 fliO 4207126 fliO Shigella flexneri 5 str. 8401 flagellar biosynthesis protein FliO YP_689436.1 2030045 D 373384 CDS YP_689437.1 110805917 4207127 2030410..2031147 1 NC_008258.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2031147 fliP 4207127 fliP Shigella flexneri 5 str. 8401 flagellar biosynthesis protein FliP YP_689437.1 2030410 D 373384 CDS YP_689438.1 110805918 4207128 2031157..2031426 1 NC_008258.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2031426 fliQ 4207128 fliQ Shigella flexneri 5 str. 8401 flagellar biosynthesis protein FliQ YP_689438.1 2031157 D 373384 CDS YP_689439.1 110805919 4207129 2031435..2032220 1 NC_008258.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2032220 fliR 4207129 fliR Shigella flexneri 5 str. 8401 flagellar biosynthesis protein FliR YP_689439.1 2031435 D 373384 CDS YP_689440.1 110805920 4207130 2032505..2033128 1 NC_008258.1 Code: K; COG: COG2771; positive regulator for ctr capsule biosynthesis, positive transcription factor 2033128 rcsA 4207130 rcsA Shigella flexneri 5 str. 8401 positive regulator for ctr capsule biosynthesis, positive transcription factor YP_689440.1 2032505 D 373384 CDS YP_689441.1 110805921 4207131 complement(2033172..2033420) 1 NC_008258.1 hypothetical protein 2033420 dsrB 4207131 dsrB Shigella flexneri 5 str. 8401 hypothetical protein YP_689441.1 2033172 R 373384 CDS YP_689442.1 110805922 4207132 2033523..2033750 1 NC_008258.1 hypothetical protein 2033750 4207132 SFV_1996 Shigella flexneri 5 str. 8401 hypothetical protein YP_689442.1 2033523 D 373384 CDS YP_689443.1 110805923 4207134 complement(2034860..2036344) 1 NC_008258.1 hypothetical protein 2036344 4207134 SFV_1998 Shigella flexneri 5 str. 8401 hypothetical protein YP_689443.1 2034860 R 373384 CDS YP_689444.1 110805924 4207135 complement(2036986..2037903) 1 NC_008258.1 Code: S; COG: COG2354; hypothetical protein 2037903 yedI 4207135 yedI Shigella flexneri 5 str. 8401 hypothetical protein YP_689444.1 2036986 R 373384 CDS YP_689445.1 110805925 4206859 2038076..2038996 1 NC_008258.1 Code: GER; COG: COG0697; hypothetical protein 2038996 yedA 4206859 yedA Shigella flexneri 5 str. 8401 hypothetical protein YP_689445.1 2038076 D 373384 CDS YP_689446.1 110805926 4206860 complement(2038985..2039455) 1 NC_008258.1 Code: L; COG: COG3727; DNA mismatch endonuclease, patch repair protein 2039455 vsr 4206860 vsr Shigella flexneri 5 str. 8401 DNA mismatch endonuclease, patch repair protein YP_689446.1 2038985 R 373384 CDS YP_689447.1 110805927 4206861 complement(2039436..2040854) 1 NC_008258.1 Code: L; COG: COG0270; DNA cytosine methylase 2040854 dcm 4206861 dcm Shigella flexneri 5 str. 8401 DNA cytosine methylase YP_689447.1 2039436 R 373384 CDS YP_689448.1 110805928 4206862 complement(2040967..2041422) 1 NC_008258.1 Code: R; COG: COG1418; hypothetical protein 2041422 yedJ 4206862 yedJ Shigella flexneri 5 str. 8401 hypothetical protein YP_689448.1 2040967 R 373384 CDS YP_689449.1 110805929 4206863 complement(2041759..2042571) 1 NC_008258.1 Code: L; COG: COG2801; ISEhe3 orfB 2042571 4206863 SFV_2004 Shigella flexneri 5 str. 8401 ISEhe3 orfB YP_689449.1 2041759 R 373384 CDS YP_689450.1 110805930 4206864 complement(2042628..2042906) 1 NC_008258.1 Code: L; COG: COG2963; ISEhe3 orfA 2042906 4206864 SFV_2005 Shigella flexneri 5 str. 8401 ISEhe3 orfA YP_689450.1 2042628 R 373384 CDS YP_689451.1 110805931 4206865 2042933..2043820 1 NC_008258.1 Code: M; COG: COG3203; outer membrane pore protein 2043820 4206865 SFV_2006 Shigella flexneri 5 str. 8401 outer membrane pore protein YP_689451.1 2042933 D 373384 CDS YP_689452.2 162139337 4206866 complement(2043745..2044650) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2044650 4206866 SFV_2007 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_689452.2 2043745 R 373384 CDS YP_689453.1 110805933 4206867 complement(2044608..2044973) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2044973 4206867 SFV_2008 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689453.1 2044608 R 373384 CDS YP_689454.1 110805934 4206868 2045037..2045246 1 NC_008258.1 outer membrane protein 2045246 4206868 SFV_2009 Shigella flexneri 5 str. 8401 outer membrane protein YP_689454.1 2045037 D 373384 CDS YP_689455.1 110805935 4206869 complement(2045718..2045993) 1 NC_008258.1 IS1 encoded protein 2045993 4206869 SFV_2010 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689455.1 2045718 R 373384 CDS YP_689456.1 110805936 4206870 2046068..2046571 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2046571 insB 4206870 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689456.1 2046068 D 373384 CDS YP_689457.1 110805937 4206871 2046617..2047468 1 NC_008258.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2047468 yedU 4206871 yedU Shigella flexneri 5 str. 8401 chaperone protein HchA YP_689457.1 2046617 D 373384 CDS YP_689458.1 110805938 4206872 complement(2047576..2048934) 1 NC_008258.1 Code: T; COG: COG0642; 2-component sensor protein 2048934 yedV 4206872 yedV Shigella flexneri 5 str. 8401 2-component sensor protein YP_689458.1 2047576 R 373384 CDS YP_689459.1 110805939 4206873 complement(2048934..2049716) 1 NC_008258.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2049716 yedW 4206873 yedW Shigella flexneri 5 str. 8401 transcriptional regulatory protein YedW YP_689459.1 2048934 R 373384 CDS YP_689460.1 110805940 4206874 2049738..2050151 1 NC_008258.1 Code: R; COG: COG2351; hypothetical protein 2050151 4206874 SFV_2015 Shigella flexneri 5 str. 8401 hypothetical protein YP_689460.1 2049738 D 373384 CDS YP_689461.1 110805941 4206876 2051265..2051900 1 NC_008258.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2051900 4206876 SFV_2017 Shigella flexneri 5 str. 8401 sulfite oxidase subunit YedZ YP_689461.1 2051265 D 373384 CDS YP_689462.1 110805942 4206877 2052158..2052808 1 NC_008258.1 Code: R; COG: COG3443; hypothetical protein 2052808 4206877 SFV_2018 Shigella flexneri 5 str. 8401 hypothetical protein YP_689462.1 2052158 D 373384 CDS YP_689463.1 110805943 4206878 complement(2053886..2054155) 1 NC_008258.1 hypothetical protein 2054155 4206878 SFV_2019 Shigella flexneri 5 str. 8401 hypothetical protein YP_689463.1 2053886 R 373384 CDS YP_689464.1 110805944 4206990 2054224..2054880 1 NC_008258.1 Code: QR; COG: COG0500; prophage protein 2054880 4206990 SFV_2020 Shigella flexneri 5 str. 8401 prophage protein YP_689464.1 2054224 D 373384 CDS YP_689465.1 110805945 4206991 2055196..2056839 1 NC_008258.1 Code: S; COG: COG4886; invasion plasmid antigen 2056839 ipaH_4 4206991 ipaH_4 Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_689465.1 2055196 D 373384 CDS YP_689466.1 110805946 4206992 complement(2057019..2057396) 1 NC_008258.1 hypothetical protein 2057396 4206992 SFV_2022 Shigella flexneri 5 str. 8401 hypothetical protein YP_689466.1 2057019 R 373384 CDS YP_689467.1 110805947 4206993 complement(2057539..2058252) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2058252 4206993 SFV_2023 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689467.1 2057539 R 373384 CDS YP_689468.1 110805948 4206994 complement(2058393..2058695) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 2058695 4206994 SFV_2024 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689468.1 2058393 R 373384 CDS YP_689469.1 110805949 4206995 complement(2058752..2059120) 1 NC_008258.1 ISSfl4 ORF3 2059120 4206995 SFV_2025 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_689469.1 2058752 R 373384 CDS YP_689470.1 110805950 4206996 complement(2059298..2059573) 1 NC_008258.1 ISSfl4 ORF3 2059573 4206996 SFV_2026 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_689470.1 2059298 R 373384 CDS YP_689471.1 110805951 4206997 complement(2059570..2059920) 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 2059920 4206997 SFV_2027 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_689471.1 2059570 R 373384 CDS YP_689472.1 110805952 4206998 complement(2059917..2060591) 1 NC_008258.1 ISSfl4 ORF1 2060591 4206998 SFV_2028 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_689472.1 2059917 R 373384 CDS YP_689473.1 110805953 4206999 complement(2060690..2060905) 1 NC_008258.1 hypothetical protein 2060905 4206999 SFV_2029 Shigella flexneri 5 str. 8401 hypothetical protein YP_689473.1 2060690 R 373384 CDS YP_689474.1 110805954 4207419 complement(2062385..2062750) 1 NC_008258.1 Code: L; COG: COG4570; endonuclease encoded by cryptic prophage 2062750 4207419 SFV_2035 Shigella flexneri 5 str. 8401 endonuclease encoded by cryptic prophage YP_689474.1 2062385 R 373384 CDS YP_689475.1 110805955 4207420 complement(2062751..2063377) 1 NC_008258.1 hypothetical protein 2063377 4207420 SFV_2036 Shigella flexneri 5 str. 8401 hypothetical protein YP_689475.1 2062751 R 373384 CDS YP_689476.1 110805956 4207421 complement(2063393..2063809) 1 NC_008258.1 hypothetical protein 2063809 4207421 SFV_2037 Shigella flexneri 5 str. 8401 hypothetical protein YP_689476.1 2063393 R 373384 CDS YP_689477.1 110805957 4207422 complement(2065064..2065630) 1 NC_008258.1 hypothetical protein 2065630 4207422 SFV_2038 Shigella flexneri 5 str. 8401 hypothetical protein YP_689477.1 2065064 R 373384 CDS YP_689478.1 110805958 4207423 2065744..2066247 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2066247 insB 4207423 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689478.1 2065744 D 373384 CDS YP_689479.1 110805959 4207424 complement(2066379..2066684) 1 NC_008258.1 hypothetical protein 2066684 4207424 SFV_2040 Shigella flexneri 5 str. 8401 hypothetical protein YP_689479.1 2066379 R 373384 CDS YP_689480.1 110805960 4207425 complement(2066723..2067226) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2067226 insB 4207425 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689480.1 2066723 R 373384 CDS YP_689481.1 110805961 4207426 2067301..2067507 1 NC_008258.1 IS1 encoded protein 2067507 4207426 SFV_2042 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689481.1 2067301 D 373384 CDS YP_689482.1 110805962 4207427 2067629..2068666 1 NC_008258.1 Code: L; COG: COG0582; integrase for prophage CP-933U 2068666 4207427 SFV_2043 Shigella flexneri 5 str. 8401 integrase for prophage CP-933U YP_689482.1 2067629 D 373384 CDS YP_689483.1 110805963 4207429 2068877..2069674 1 NC_008258.1 Code: S; COG: COG3228; hypothetical protein 2069674 4207429 SFV_2045 Shigella flexneri 5 str. 8401 hypothetical protein YP_689483.1 2068877 D 373384 CDS YP_689484.1 110805964 4207431 2070525..2071274 1 NC_008258.1 integrase 2071274 4207431 SFV_2047 Shigella flexneri 5 str. 8401 integrase YP_689484.1 2070525 D 373384 CDS YP_689485.1 110805965 4207432 complement(2071381..2071947) 1 NC_008258.1 IS911 ORF2 2071947 4207432 SFV_2048 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_689485.1 2071381 R 373384 CDS YP_689486.1 110805966 4207433 complement(2072248..2072550) 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 2072550 4207433 SFV_2049 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_689486.1 2072248 R 373384 CDS YP_689487.1 110805967 4207435 2073177..2073479 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 2073479 4207435 SFV_2051 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689487.1 2073177 D 373384 CDS YP_689488.1 110805968 4207176 2073620..2074333 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2074333 4207176 SFV_2052 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689488.1 2073620 D 373384 CDS YP_689489.1 110805969 4207177 2074685..2076139 1 NC_008258.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2076139 amn 4207177 amn Shigella flexneri 5 str. 8401 AMP nucleosidase YP_689489.1 2074685 D 373384 CDS YP_689490.1 110805970 4207178 2076482..2077198 1 NC_008258.1 Code: S; COG: COG0217; hypothetical protein 2077198 4207178 SFV_2054 Shigella flexneri 5 str. 8401 hypothetical protein YP_689490.1 2076482 D 373384 CDS YP_689491.1 110805971 4207180 complement(2078139..2078636) 1 NC_008258.1 hypothetical protein 2078636 4207180 SFV_2056 Shigella flexneri 5 str. 8401 hypothetical protein YP_689491.1 2078139 R 373384 CDS YP_689492.1 110805972 4207181 complement(2078627..2079127) 1 NC_008258.1 hypothetical protein 2079127 4207181 SFV_2057 Shigella flexneri 5 str. 8401 hypothetical protein YP_689492.1 2078627 R 373384 CDS YP_689493.1 110805973 4207183 complement(2079575..2080525) 1 NC_008258.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2080525 cbl 4207183 cbl Shigella flexneri 5 str. 8401 transcriptional regulator Cbl YP_689493.1 2079575 R 373384 CDS YP_689494.1 110805974 4207184 complement(2080627..2081544) 1 NC_008258.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2081544 nac 4207184 nac Shigella flexneri 5 str. 8401 nitrogen assimilation transcriptional regulator YP_689494.1 2080627 R 373384 CDS YP_689495.1 110805975 4207186 complement(2082003..2082938) 1 NC_008258.1 Code: S; COG: COG1376; hypothetical protein 2082938 erfK 4207186 erfK Shigella flexneri 5 str. 8401 hypothetical protein YP_689495.1 2082003 R 373384 CDS YP_689496.1 110805976 4207187 complement(2083000..2084079) 1 NC_008258.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2084079 cobT 4207187 cobT Shigella flexneri 5 str. 8401 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_689496.1 2083000 R 373384 CDS YP_689497.1 110805977 4207188 complement(2084091..2084834) 1 NC_008258.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2084834 cobS 4207188 cobS Shigella flexneri 5 str. 8401 cobalamin synthase YP_689497.1 2084091 R 373384 CDS YP_689498.1 110805978 4207189 complement(2084831..2085376) 1 NC_008258.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2085376 cobU 4207189 cobU Shigella flexneri 5 str. 8401 adenosylcobinamide kinase YP_689498.1 2084831 R 373384 CDS YP_689499.1 110805979 4207190 complement(2086373..2087215) 1 NC_008258.1 hypothetical protein 2087215 4207190 SFV_2066 Shigella flexneri 5 str. 8401 hypothetical protein YP_689499.1 2086373 R 373384 CDS YP_689500.1 110805980 4207191 2087736..2087861 1 NC_008258.1 IS600 ORF1 2087861 4207191 SFV_2067 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689500.1 2087736 D 373384 CDS YP_689501.1 110805981 4207136 2088002..2088742 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2088742 4207136 SFV_2068 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689501.1 2088002 D 373384 CDS YP_689502.1 110805982 4207137 complement(2089218..2090057) 1 NC_008258.1 Code: L; COG: COG0582; integrase of prophage 2090057 4207137 SFV_2069 Shigella flexneri 5 str. 8401 integrase of prophage YP_689502.1 2089218 R 373384 CDS YP_689503.1 110805983 4207138 2090239..2091663 1 NC_008258.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2091663 sbcB 4207138 sbcB Shigella flexneri 5 str. 8401 exonuclease I YP_689503.1 2090239 D 373384 CDS YP_689504.1 110805984 4207139 complement(2091706..2091933) 1 NC_008258.1 Code: O; COG: COG0425; hypothetical protein 2091933 yeeD 4207139 yeeD Shigella flexneri 5 str. 8401 hypothetical protein YP_689504.1 2091706 R 373384 CDS YP_689505.1 110805985 4207140 complement(2091947..2092951) 1 NC_008258.1 Code: R; COG: COG2391; transport system permease 2092951 yeeE 4207140 yeeE Shigella flexneri 5 str. 8401 transport system permease YP_689505.1 2091947 R 373384 CDS YP_689506.1 110805986 4207141 complement(2093184..2094542) 1 NC_008258.1 Code: E; COG: COG0531; amino acid/amine transport protein 2094542 yeeF 4207141 yeeF Shigella flexneri 5 str. 8401 amino acid/amine transport protein YP_689506.1 2093184 R 373384 CDS YP_689507.1 110805987 4207142 complement(2094755..2095738) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2095738 yeeY 4207142 yeeY Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_689507.1 2094755 R 373384 CDS YP_689508.1 110805988 4207143 complement(2095784..2096608) 1 NC_008258.1 Code: MG; COG: COG0451; sugar metabolism protein 2096608 4207143 SFV_2075 Shigella flexneri 5 str. 8401 sugar metabolism protein YP_689508.1 2095784 R 373384 CDS YP_689509.1 110805989 4207144 complement(2096691..2096945) 1 NC_008258.1 Code: S; COG: COG4115; hypothetical protein 2096945 4207144 SFV_2076 Shigella flexneri 5 str. 8401 hypothetical protein YP_689509.1 2096691 R 373384 CDS YP_689510.1 110805990 4207145 complement(2096967..2097470) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2097470 insB 4207145 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689510.1 2096967 R 373384 CDS YP_689511.1 110805991 4207146 complement(2097698..2097970) 1 NC_008258.1 Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 2097970 yefM 4207146 yefM Shigella flexneri 5 str. 8401 antitoxin YefM YP_689511.1 2097698 R 373384 CDS YP_689512.1 110805992 4207147 2098440..2099339 1 NC_008258.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2099339 hisG 4207147 hisG Shigella flexneri 5 str. 8401 ATP phosphoribosyltransferase YP_689512.1 2098440 D 373384 CDS YP_689513.1 110805993 4207148 2099345..2100649 1 NC_008258.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2100649 hisD 4207148 hisD Shigella flexneri 5 str. 8401 histidinol dehydrogenase YP_689513.1 2099345 D 373384 CDS YP_689514.1 110805994 4207149 2100646..2101716 1 NC_008258.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2101716 hisC 4207149 hisC Shigella flexneri 5 str. 8401 histidinol-phosphate aminotransferase YP_689514.1 2100646 D 373384 CDS YP_689515.1 110805995 4207150 2101716..2102783 1 NC_008258.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2102783 hisB 4207150 hisB Shigella flexneri 5 str. 8401 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_689515.1 2101716 D 373384 CDS YP_689516.1 110805996 4207151 2102783..2103373 1 NC_008258.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2103373 hisH 4207151 hisH Shigella flexneri 5 str. 8401 imidazole glycerol phosphate synthase subunit HisH YP_689516.1 2102783 D 373384 CDS YP_689517.1 110805997 4207152 2103373..2104110 1 NC_008258.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2104110 hisA 4207152 hisA Shigella flexneri 5 str. 8401 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_689517.1 2103373 D 373384 CDS YP_689518.1 110805998 4207153 2104092..2104868 1 NC_008258.1 imidazole glycerol phosphate synthase subunit in heterodimer with HisH; catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2104868 hisF 4207153 hisF Shigella flexneri 5 str. 8401 imidazole glycerol phosphate synthase subunit HisF YP_689518.1 2104092 D 373384 CDS YP_689519.1 110805999 4207154 2104862..2105473 1 NC_008258.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2105473 hisI 4207154 hisI Shigella flexneri 5 str. 8401 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_689519.1 2104862 D 373384 CDS YP_689520.1 110806000 4207155 complement(2105659..2106672) 1 NC_008258.1 Code: M; COG: COG3765; regulator of length of O-antigen component of lipopolysaccharide chains 2106672 wzzB 4207155 wzzB Shigella flexneri 5 str. 8401 regulator of length of O-antigen component of lipopolysaccharide chains YP_689520.1 2105659 R 373384 CDS YP_689521.1 110806001 4207247 complement(2108152..2109558) 1 NC_008258.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2109558 gnd 4207247 gnd Shigella flexneri 5 str. 8401 6-phosphogluconate dehydrogenase YP_689521.1 2108152 R 373384 CDS YP_689522.1 110806002 4207248 complement(2110675..2111325) 1 NC_008258.1 hypothetical protein 2111325 4207248 SFV_2090 Shigella flexneri 5 str. 8401 hypothetical protein YP_689522.1 2110675 R 373384 CDS YP_689523.1 110806003 4207249 complement(2112825..2113973) 1 NC_008258.1 O-antigen polymerase 2113973 rfc 4207249 rfc Shigella flexneri 5 str. 8401 O-antigen polymerase YP_689523.1 2112825 R 373384 CDS YP_689524.1 110806004 4207250 complement(2113993..2114898) 1 NC_008258.1 dTDP-rhamnosyl transferase 2114898 rfbG 4207250 rfbG Shigella flexneri 5 str. 8401 dTDP-rhamnosyl transferase YP_689524.1 2113993 R 373384 CDS YP_689525.1 110806005 4207251 complement(2114891..2115652) 1 NC_008258.1 dTDP-rhamnosyl transferase 2115652 rfbF 4207251 rfbF Shigella flexneri 5 str. 8401 dTDP-rhamnosyl transferase YP_689525.1 2114891 R 373384 CDS YP_689526.1 110806006 4207252 complement(2115811..2117067) 1 NC_008258.1 polysaccharide biosynthesis protein 2117067 rfbE 4207252 rfbE Shigella flexneri 5 str. 8401 polysaccharide biosynthesis protein YP_689526.1 2115811 R 373384 CDS YP_689527.1 110806007 4207253 complement(2117083..2117628) 1 NC_008258.1 Code: M; COG: COG1898; dTDP-6-deoxy-L-mannose-dehydrogenase 2117628 rfbC 4207253 rfbC Shigella flexneri 5 str. 8401 dTDP-6-deoxy-L-mannose-dehydrogenase YP_689527.1 2117083 R 373384 CDS YP_689528.1 110806008 4207254 complement(2117633..2118511) 1 NC_008258.1 Code: M; COG: COG1209; glucose-1-phosphate thymidylyltransferase 2118511 rfbA 4207254 rfbA Shigella flexneri 5 str. 8401 glucose-1-phosphate thymidylyltransferase YP_689528.1 2117633 R 373384 CDS YP_689529.1 110806009 4207255 complement(2118570..2119469) 1 NC_008258.1 with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose; dTDP-4-dehydrorhamnose reductase 2119469 rfbD 4207255 rfbD Shigella flexneri 5 str. 8401 dTDP-4-dehydrorhamnose reductase YP_689529.1 2118570 R 373384 CDS YP_689530.1 110806010 4207256 complement(2119469..2120554) 1 NC_008258.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose; dTDP-glucose 4,6 dehydratase 2120554 rfbB 4207256 rfbB Shigella flexneri 5 str. 8401 dTDP-glucose 4,6 dehydratase YP_689530.1 2119469 R 373384 CDS YP_689531.1 110806011 4207257 complement(2120927..2121820) 1 NC_008258.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 2121820 galF 4207257 galF Shigella flexneri 5 str. 8401 UTP-glucose-1-phosphate uridylyltransferase YP_689531.1 2120927 R 373384 CDS YP_689532.1 110806012 4207259 complement(2123400..2124620) 1 NC_008258.1 Code: M; COG: COG0438; colanic acid biosynthesis glycosyl transferase 2124620 wcaL 4207259 wcaL Shigella flexneri 5 str. 8401 colanic acid biosynthesis glycosyl transferase YP_689532.1 2123400 R 373384 CDS YP_689533.1 110806013 4207260 complement(2124617..2125897) 1 NC_008258.1 Code: S; COG: COG2327; pyruvyl transferase 2125897 wcaK 4207260 wcaK Shigella flexneri 5 str. 8401 pyruvyl transferase YP_689533.1 2124617 R 373384 CDS YP_689534.1 110806014 4207261 complement(2126077..2127555) 1 NC_008258.1 Code: R; COG: COG2244; colanic acid exporter 2127555 wzxC 4207261 wzxC Shigella flexneri 5 str. 8401 colanic acid exporter YP_689534.1 2126077 R 373384 CDS YP_689535.1 110806015 4207262 complement(2127557..2128951) 1 NC_008258.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase 2128951 wcaJ 4207262 wcaJ Shigella flexneri 5 str. 8401 UDP-glucose lipid carrier transferase YP_689535.1 2127557 R 373384 CDS YP_689536.1 110806016 4207264 complement(2130570..2131889) 1 NC_008258.1 Code: M; COG: COG0836; mannose-1-phosphate guanylyltransferase 2131889 cpsB 4207264 cpsB Shigella flexneri 5 str. 8401 mannose-1-phosphate guanylyltransferase YP_689536.1 2130570 R 373384 CDS YP_689537.1 110806017 4206800 complement(2132009..2133232) 1 NC_008258.1 Code: M; COG: COG0438; glycosyl transferase 2133232 wcaI 4206800 wcaI Shigella flexneri 5 str. 8401 glycosyl transferase YP_689537.1 2132009 R 373384 CDS YP_689538.1 110806018 4206801 complement(2133229..2133708) 1 NC_008258.1 Code: LR; COG: COG0494; GDP-mannose mannosyl hydrolase 2133708 wcaH 4206801 wcaH Shigella flexneri 5 str. 8401 GDP-mannose mannosyl hydrolase YP_689538.1 2133229 R 373384 CDS YP_689539.1 110806019 4206802 complement(2133708..2134676) 1 NC_008258.1 Code: MG; COG: COG0451; nucleotide di-P-sugar epimerase or dehydratase 2134676 wcaG 4206802 wcaG Shigella flexneri 5 str. 8401 nucleotide di-P-sugar epimerase or dehydratase YP_689539.1 2133708 R 373384 CDS YP_689540.1 110806020 4206803 complement(2134679..2135800) 1 NC_008258.1 Code: M; COG: COG1089; GDP-D-mannose dehydratase 2135800 gmd 4206803 gmd Shigella flexneri 5 str. 8401 GDP-D-mannose dehydratase YP_689540.1 2134679 R 373384 CDS YP_689541.1 110806021 4206804 complement(2135826..2136374) 1 NC_008258.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF 2136374 wcaF 4206804 wcaF Shigella flexneri 5 str. 8401 colanic acid biosynthesis acetyltransferase WcaF YP_689541.1 2135826 R 373384 CDS YP_689542.1 110806022 4206805 complement(2136390..2136689) 1 NC_008258.1 IS1 encoded protein 2136689 4206805 SFV_2112 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689542.1 2136390 R 373384 CDS YP_689543.1 110806023 4206806 2136764..2137267 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2137267 insB 4206806 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689543.1 2136764 D 373384 CDS YP_689544.1 110806024 4206807 complement(2137278..2137910) 1 NC_008258.1 Code: M; COG: COG0463; colanic acid biosynthesis glycosyl transferase 2137910 wcaE 4206807 wcaE Shigella flexneri 5 str. 8401 colanic acid biosynthesis glycosyl transferase YP_689544.1 2137278 R 373384 CDS YP_689545.1 110806025 4206808 complement(2137924..2139141) 1 NC_008258.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein 2139141 wcaD 4206808 wcaD Shigella flexneri 5 str. 8401 colanic acid biosynthesis protein YP_689545.1 2137924 R 373384 CDS YP_689546.1 110806026 4206809 complement(2139116..2140333) 1 NC_008258.1 Code: M; COG: COG0438; glycosyl transferase 2140333 wcaC 4206809 wcaC Shigella flexneri 5 str. 8401 glycosyl transferase YP_689546.1 2139116 R 373384 CDS YP_689547.1 110806027 4206810 complement(2140330..2140818) 1 NC_008258.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB 2140818 wcaB 4206810 wcaB Shigella flexneri 5 str. 8401 colanic acid biosynthesis acetyltransferase WcaB YP_689547.1 2140330 R 373384 CDS YP_689548.1 110806028 4206811 complement(2140821..2141660) 1 NC_008258.1 Code: M; COG: COG0463; glycosyl transferase 2141660 wcaA 4206811 wcaA Shigella flexneri 5 str. 8401 glycosyl transferase YP_689548.1 2140821 R 373384 CDS YP_689549.1 110806029 4206812 complement(2141753..2143915) 1 NC_008258.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2143915 4206812 SFV_2119 Shigella flexneri 5 str. 8401 tyrosine kinase YP_689549.1 2141753 R 373384 CDS YP_689550.1 110806030 4206813 complement(2143918..2144361) 1 NC_008258.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2144361 wzb 4206813 wzb Shigella flexneri 5 str. 8401 tyrosine phosphatase YP_689550.1 2143918 R 373384 CDS YP_689551.1 110806031 4206814 complement(2144367..2145491) 1 NC_008258.1 Code: M; COG: COG1596; polysaccharide export protein 2145491 wza 4206814 wza Shigella flexneri 5 str. 8401 polysaccharide export protein YP_689551.1 2144367 R 373384 CDS YP_689552.1 110806032 4206815 2146099..2147748 1 NC_008258.1 transport protein 2147748 yegH 4206815 yegH Shigella flexneri 5 str. 8401 transport protein YP_689552.1 2146099 D 373384 CDS YP_689553.1 110806033 4206816 complement(2148200..2150053) 1 NC_008258.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein 2150053 asmA 4206816 asmA Shigella flexneri 5 str. 8401 assembly protein YP_689553.1 2148200 R 373384 CDS YP_689554.1 110806034 4206817 complement(2150075..2150656) 1 NC_008258.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2150656 dcd 4206817 dcd Shigella flexneri 5 str. 8401 deoxycytidine triphosphate deaminase YP_689554.1 2150075 R 373384 CDS YP_689555.1 110806035 4206818 complement(2150748..2151443) 1 NC_008258.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2151443 udk 4206818 udk Shigella flexneri 5 str. 8401 uridine kinase YP_689555.1 2150748 R 373384 CDS YP_689556.1 110806036 4206819 complement(2152151..2153347) 1 NC_008258.1 Code: L; COG: COG3547; ISSfl2 ORF 2153347 4206819 SFV_2126 Shigella flexneri 5 str. 8401 ISSfl2 ORF YP_689556.1 2152151 R 373384 CDS YP_689557.1 110806037 4206971 2153781..2154440 1 NC_008258.1 Code: R; COG: COG4245; hypothetical protein 2154440 4206971 SFV_2127 Shigella flexneri 5 str. 8401 hypothetical protein YP_689557.1 2153781 D 373384 CDS YP_689558.1 110806038 4206972 2154437..2155198 1 NC_008258.1 hypothetical protein 2155198 4206972 SFV_2128 Shigella flexneri 5 str. 8401 hypothetical protein YP_689558.1 2154437 D 373384 CDS YP_689559.1 110806039 4206973 2155195..2156718 1 NC_008258.1 Code: R; COG: COG4248; chaperonin 2156718 4206973 SFV_2129 Shigella flexneri 5 str. 8401 chaperonin YP_689559.1 2155195 D 373384 CDS YP_689560.1 110806040 4206974 complement(2157147..2158499) 1 NC_008258.1 Code: O; COG: COG0443; chaperone 2158499 yegD 4206974 yegD Shigella flexneri 5 str. 8401 chaperone YP_689560.1 2157147 R 373384 CDS YP_689561.1 110806041 4206975 2158633..2159481 1 NC_008258.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyl-adenine DNA glycosylase 2159481 alkA 4206975 alkA Shigella flexneri 5 str. 8401 3-methyl-adenine DNA glycosylase YP_689561.1 2158633 D 373384 CDS YP_689562.1 110806042 4206977 2162710..2163906 1 NC_008258.1 Code: L; COG: COG3547; ISSfl2 ORF 2163906 4206977 SFV_2133 Shigella flexneri 5 str. 8401 ISSfl2 ORF YP_689562.1 2162710 D 373384 CDS YP_689563.1 110806043 4206978 2163908..2164960 1 NC_008258.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2164960 4206978 SFV_2134 Shigella flexneri 5 str. 8401 multidrug efflux system subunit MdtA YP_689563.1 2163908 D 373384 CDS YP_689564.1 110806044 4206979 2164960..2167518 1 NC_008258.1 Code: V; COG: COG0841; hypothetical protein 2167518 yegN 4206979 yegN Shigella flexneri 5 str. 8401 hypothetical protein YP_689564.1 2164960 D 373384 CDS YP_689565.1 110806045 4206980 2167588..2168082 1 NC_008258.1 hypothetical protein 2168082 4206980 SFV_2136 Shigella flexneri 5 str. 8401 hypothetical protein YP_689565.1 2167588 D 373384 CDS YP_689566.1 110806046 4206981 2168083..2171148 1 NC_008258.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2171148 yegO 4206981 yegO Shigella flexneri 5 str. 8401 multidrug efflux system subunit MdtC YP_689566.1 2168083 D 373384 CDS YP_689567.2 162139336 4206982 2171255..2172565 1 NC_008258.1 Code: GEPR; COG: COG0477; multidrug ABC transporter 2172565 yegB 4206982 yegB Shigella flexneri 5 str. 8401 multidrug ABC transporter YP_689567.2 2171255 D 373384 CDS YP_689568.1 110806048 4206983 2172562..2173965 1 NC_008258.1 Code: T; COG: COG0642; signal transduction histidine-protein kinase BaeS 2173965 baeS 4206983 baeS Shigella flexneri 5 str. 8401 signal transduction histidine-protein kinase BaeS YP_689568.1 2172562 D 373384 CDS YP_689569.1 110806049 4206984 2173962..2174684 1 NC_008258.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2174684 baeR 4206984 baeR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator BaeR YP_689569.1 2173962 D 373384 CDS YP_689570.1 110806050 4206985 2174836..2175207 1 NC_008258.1 Code: S; COG: COG3422; hypothetical protein 2175207 4206985 SFV_2141 Shigella flexneri 5 str. 8401 hypothetical protein YP_689570.1 2174836 D 373384 CDS YP_689571.1 110806051 4206986 2175213..2176715 1 NC_008258.1 Code: O; COG: COG0826; hypothetical protein 2176715 yegQ 4206986 yegQ Shigella flexneri 5 str. 8401 hypothetical protein YP_689571.1 2175213 D 373384 CDS YP_689572.1 110806052 4206987 complement(2177057..2177434) 1 NC_008258.1 hypothetical protein 2177434 4206987 SFV_2143 Shigella flexneri 5 str. 8401 hypothetical protein YP_689572.1 2177057 R 373384 CDS YP_689573.1 110806053 4206988 2177782..2178681 1 NC_008258.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2178681 4206988 SFV_2144 Shigella flexneri 5 str. 8401 lipid kinase YP_689573.1 2177782 D 373384 CDS YP_689574.1 110806054 4206989 complement(2178763..2179536) 1 NC_008258.1 Code: KG; COG: COG1349; galactitol utilization operon repressor 2179536 gatR 4206989 gatR Shigella flexneri 5 str. 8401 galactitol utilization operon repressor YP_689574.1 2178763 R 373384 CDS YP_689575.1 110806055 4207157 complement(2180730..2182085) 1 NC_008258.1 Code: G; COG: COG3775; PTS system galactitol-specific enzyme IIC 2182085 gatC 4207157 gatC Shigella flexneri 5 str. 8401 PTS system galactitol-specific enzyme IIC YP_689575.1 2180730 R 373384 CDS YP_689576.1 110806056 4207158 complement(2182089..2182373) 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2182373 gatB 4207158 gatB Shigella flexneri 5 str. 8401 PTS system galactitol-specific transporter subunit IIB YP_689576.1 2182089 R 373384 CDS YP_689577.1 110806057 4207160 complement(2182866..2184128) 1 NC_008258.1 Code: G; COG: COG4573; tagatose 6-phosphate kinase 1 2184128 gatZ 4207160 gatZ Shigella flexneri 5 str. 8401 tagatose 6-phosphate kinase 1 YP_689577.1 2182866 R 373384 CDS YP_689578.2 162139335 4207161 complement(2184157..2185011) 1 NC_008258.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2185011 gatY 4207161 gatY Shigella flexneri 5 str. 8401 tagatose-bisphosphate aldolase YP_689578.2 2184157 R 373384 CDS YP_689579.1 110806059 4207162 complement(2185319..2186371) 1 NC_008258.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2186371 4207162 SFV_2152 Shigella flexneri 5 str. 8401 fructose-bisphosphate aldolase YP_689579.1 2185319 R 373384 CDS YP_689580.1 110806060 4207163 2186628..2187905 1 NC_008258.1 Code: GEPR; COG: COG0477; nucleoside permease 2187905 yegT 4207163 yegT Shigella flexneri 5 str. 8401 nucleoside permease YP_689580.1 2186628 D 373384 CDS YP_689581.1 110806061 4207165 2188902..2189867 1 NC_008258.1 Code: G; COG: COG0524; kinase 2189867 4207165 SFV_2155 Shigella flexneri 5 str. 8401 kinase YP_689581.1 2188902 D 373384 CDS YP_689582.1 110806062 4207166 complement(2189841..2190587) 1 NC_008258.1 transcriptional regulator 2190587 yegW 4207166 yegW Shigella flexneri 5 str. 8401 transcriptional regulator YP_689582.1 2189841 R 373384 CDS YP_689583.1 110806063 4207167 complement(2190635..2191456) 1 NC_008258.1 Code: M; COG: COG3757; hypothetical protein 2191456 yegX 4207167 yegX Shigella flexneri 5 str. 8401 hypothetical protein YP_689583.1 2190635 R 373384 CDS YP_689584.1 110806064 4207168 complement(2191521..2192321) 1 NC_008258.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2192321 thiD 4207168 thiD Shigella flexneri 5 str. 8401 phosphomethylpyrimidine kinase YP_689584.1 2191521 R 373384 CDS YP_689585.1 110806065 4207169 complement(2192318..2193106) 1 NC_008258.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2193106 thiM 4207169 thiM Shigella flexneri 5 str. 8401 hydroxyethylthiazole kinase YP_689585.1 2192318 R 373384 CDS YP_689586.1 110806066 4207170 complement(2193329..2193601) 1 NC_008258.1 Code: S; COG: COG1937; hypothetical protein 2193601 yohL 4207170 yohL Shigella flexneri 5 str. 8401 hypothetical protein YP_689586.1 2193329 R 373384 CDS YP_689587.1 110806067 4207171 2193723..2194571 1 NC_008258.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2194571 yohM 4207171 yohM Shigella flexneri 5 str. 8401 nickel/cobalt efflux protein RcnA YP_689587.1 2193723 D 373384 CDS YP_689588.1 110806068 4207172 2194790..2195128 1 NC_008258.1 Code: S; COG: COG5455; hypothetical protein 2195128 4207172 SFV_2162 Shigella flexneri 5 str. 8401 hypothetical protein YP_689588.1 2194790 D 373384 CDS YP_689589.1 110806069 4207173 complement(2195428..2196243) 1 NC_008258.1 type-1 fimbrial protein 2196243 yehA 4207173 yehA Shigella flexneri 5 str. 8401 type-1 fimbrial protein YP_689589.1 2195428 R 373384 CDS YP_689590.1 110806070 4207174 complement(2196259..2198739) 1 NC_008258.1 Code: NU; COG: COG3188; outer membrane protein 2198739 yehB 4207174 yehB Shigella flexneri 5 str. 8401 outer membrane protein YP_689590.1 2196259 R 373384 CDS YP_689591.1 110806071 4207175 complement(2198755..2199318) 1 NC_008258.1 Code: NU; COG: COG3121; chaperone 2199318 yehC 4207175 yehC Shigella flexneri 5 str. 8401 chaperone YP_689591.1 2198755 R 373384 CDS YP_689592.1 110806072 4208440 complement(2199377..2199880) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2199880 insB 4208440 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689592.1 2199377 R 373384 CDS YP_689593.1 110806073 4208441 2199955..2200188 1 NC_008258.1 IS1 encoded protein 2200188 4208441 SFV_2167 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689593.1 2199955 D 373384 CDS YP_689594.1 110806074 4208442 complement(2200287..2200829) 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 2200829 yehD 4208442 yehD Shigella flexneri 5 str. 8401 fimbrial-like protein YP_689594.1 2200287 R 373384 CDS YP_689595.1 110806075 4208443 complement(2201665..2202774) 1 NC_008258.1 Code: D; COG: COG0489; ATPase 2202774 mrp 4208443 mrp Shigella flexneri 5 str. 8401 ATPase YP_689595.1 2201665 R 373384 CDS YP_689596.1 110806076 4208444 2202906..2204939 1 NC_008258.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2204939 metG 4208444 metG Shigella flexneri 5 str. 8401 methionyl-tRNA synthetase YP_689596.1 2202906 D 373384 CDS YP_689597.1 110806077 4208446 2205512..2205637 1 NC_008258.1 IS600 ORF1 2205637 4208446 SFV_2172 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689597.1 2205512 D 373384 CDS YP_689598.1 110806078 4208447 2205778..2206491 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2206491 4208447 SFV_2173 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689598.1 2205778 D 373384 CDS YP_689599.1 110806079 4208449 2208295..2210139 1 NC_008258.1 molybdate metabolism regulator 2210139 4208449 SFV_2175 Shigella flexneri 5 str. 8401 molybdate metabolism regulator YP_689599.1 2208295 D 373384 CDS YP_689600.1 110806080 4208450 2210149..2211840 1 NC_008258.1 hypothetical protein 2211840 4208450 SFV_2176 Shigella flexneri 5 str. 8401 hypothetical protein YP_689600.1 2210149 D 373384 CDS YP_689601.1 110806081 4208451 complement(2211775..2212278) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2212278 insB 4208451 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689601.1 2211775 R 373384 CDS YP_689602.1 110806082 4208452 2212353..2212541 1 NC_008258.1 IS1 encoded protein 2212541 4208452 SFV_2178 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689602.1 2212353 D 373384 CDS YP_689603.1 110806083 4208453 2212563..2213024 1 NC_008258.1 Code: S; COG: COG4808; hypothetical protein 2213024 yehR 4208453 yehR Shigella flexneri 5 str. 8401 hypothetical protein YP_689603.1 2212563 D 373384 CDS YP_689604.1 110806084 4208454 complement(2213065..2213592) 1 NC_008258.1 Code: S; COG: COG4807; hypothetical protein 2213592 yehS 4208454 yehS Shigella flexneri 5 str. 8401 hypothetical protein YP_689604.1 2213065 R 373384 CDS YP_689605.1 110806085 4208455 complement(2213582..2214301) 1 NC_008258.1 unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT 2214301 yehT 4208455 yehT Shigella flexneri 5 str. 8401 two-component response-regulatory protein YehT YP_689605.1 2213582 R 373384 CDS YP_689606.1 110806086 4208456 complement(2214298..2215944) 1 NC_008258.1 Code: T; COG: COG3275; 2-component sensor protein 2215944 yehU 4208456 yehU Shigella flexneri 5 str. 8401 2-component sensor protein YP_689606.1 2214298 R 373384 CDS YP_689607.1 110806087 4208457 2216191..2217537 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 2217537 4208457 SFV_2183 Shigella flexneri 5 str. 8401 IS4 orf YP_689607.1 2216191 D 373384 CDS YP_689608.1 110806088 4208458 2217935..2218183 1 NC_008258.1 DNA damage-inducible protein 2218183 4208458 SFV_2184 Shigella flexneri 5 str. 8401 DNA damage-inducible protein YP_689608.1 2217935 D 373384 CDS YP_689609.1 110806089 4209327 complement(2218299..2218568) 1 NC_008258.1 hypothetical protein 2218568 4209327 SFV_2185 Shigella flexneri 5 str. 8401 hypothetical protein YP_689609.1 2218299 R 373384 CDS YP_689610.1 110806090 4209328 2218637..2219293 1 NC_008258.1 Code: QR; COG: COG0500; prophage protein 2219293 4209328 SFV_2186 Shigella flexneri 5 str. 8401 prophage protein YP_689610.1 2218637 D 373384 CDS YP_689611.1 110806091 4209329 2219609..2221252 1 NC_008258.1 Code: S; COG: COG4886; invasion plasmid antigen 2221252 ipaH_5 4209329 ipaH_5 Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_689611.1 2219609 D 373384 CDS YP_689612.1 110806092 4209330 complement(2221432..2222055) 1 NC_008258.1 hypothetical protein 2222055 4209330 SFV_2188 Shigella flexneri 5 str. 8401 hypothetical protein YP_689612.1 2221432 R 373384 CDS YP_689613.1 110806093 4209331 complement(2222006..2223421) 1 NC_008258.1 tail fiber protein 2223421 4209331 SFV_2189 Shigella flexneri 5 str. 8401 tail fiber protein YP_689613.1 2222006 R 373384 CDS YP_689614.1 110806094 4209332 complement(2223585..2223986) 1 NC_008258.1 tail fiber assembly protein 2223986 4209332 SFV_2190 Shigella flexneri 5 str. 8401 tail fiber assembly protein YP_689614.1 2223585 R 373384 CDS YP_689615.1 110806095 4209333 complement(2223989..2224402) 1 NC_008258.1 IS1 encoded protein 2224402 4209333 SFV_2191 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689615.1 2223989 R 373384 CDS YP_689616.1 110806096 4209334 2224638..2225141 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2225141 insB 4209334 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689616.1 2224638 D 373384 CDS YP_689617.1 110806097 4209335 2225379..2225849 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 2225849 4209335 SFV_2193 Shigella flexneri 5 str. 8401 fimbrial-like protein YP_689617.1 2225379 D 373384 CDS YP_689618.1 110806098 4209336 complement(2225843..2226346) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2226346 insB 4209336 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689618.1 2225843 R 373384 CDS YP_689619.1 110806100 4209338 complement(2226574..2227599) 1 NC_008258.1 bacteriophage protein 2227599 4209338 SFV_2196 Shigella flexneri 5 str. 8401 bacteriophage protein YP_689619.1 2226574 R 373384 CDS YP_689620.1 110806099 4209337 2227466..2227960 1 NC_008258.1 hypothetical protein 2227960 4209337 SFV_2195 Shigella flexneri 5 str. 8401 hypothetical protein YP_689620.1 2227466 D 373384 CDS YP_689621.1 110806101 4209339 complement(2227985..2228698) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2228698 4209339 SFV_2197 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689621.1 2227985 R 373384 CDS YP_689622.1 110806102 4209340 complement(2228839..2228964) 1 NC_008258.1 IS600 ORF1 2228964 4209340 SFV_2198 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689622.1 2228839 R 373384 CDS YP_689623.1 110806103 4209341 2229207..2230004 1 NC_008258.1 integrase 2230004 4209341 SFV_2199 Shigella flexneri 5 str. 8401 integrase YP_689623.1 2229207 D 373384 CDS YP_689624.1 110806104 4209343 2230332..2230658 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 2230658 4209343 SFV_2201 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_689624.1 2230332 D 373384 CDS YP_689625.1 110806105 4209344 2230658..2231545 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 2231545 4209344 SFV_2202 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_689625.1 2230658 D 373384 CDS YP_689626.1 110806106 4209345 2232103..2232210 1 NC_008258.1 hypothetical protein 2232210 4209345 SFV_2203 Shigella flexneri 5 str. 8401 hypothetical protein YP_689626.1 2232103 D 373384 CDS YP_689627.1 110806107 4209346 complement(2232191..2232922) 1 NC_008258.1 Code: E; COG: COG1174; transport system permease 2232922 yehW 4209346 yehW Shigella flexneri 5 str. 8401 transport system permease YP_689627.1 2232191 R 373384 CDS YP_689628.1 110806108 4209503 complement(2232927..2233853) 1 NC_008258.1 Code: E; COG: COG1125; ABC transporter ATP-binding protein 2233853 yehX 4209503 yehX Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_689628.1 2232927 R 373384 CDS YP_689629.1 110806109 4209504 complement(2233846..2235003) 1 NC_008258.1 Code: E; COG: COG1174; transport system permease 2235003 yehY 4209504 yehY Shigella flexneri 5 str. 8401 transport system permease YP_689629.1 2233846 R 373384 CDS YP_689630.1 110806110 4209505 complement(2235010..2235927) 1 NC_008258.1 Code: M; COG: COG1732; transport system permease 2235927 yehZ 4209505 yehZ Shigella flexneri 5 str. 8401 transport system permease YP_689630.1 2235010 R 373384 CDS YP_689631.1 110806111 4209506 complement(2236179..2238446) 1 NC_008258.1 Code: G; COG: COG1472; beta-D-glucoside glucohydrolase 2238446 bglX 4209506 bglX Shigella flexneri 5 str. 8401 beta-D-glucoside glucohydrolase YP_689631.1 2236179 R 373384 CDS YP_689632.1 110806112 4209507 2238672..2240387 1 NC_008258.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2240387 dld 4209507 dld Shigella flexneri 5 str. 8401 D-lactate dehydrogenase YP_689632.1 2238672 D 373384 CDS YP_689633.1 110806113 4209508 complement(2240425..2241357) 1 NC_008258.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2241357 pbpG 4209508 pbpG Shigella flexneri 5 str. 8401 D-alanyl-D-alanine endopeptidase YP_689633.1 2240425 R 373384 CDS YP_689634.1 110806114 4209509 complement(2241531..2242118) 1 NC_008258.1 hypothetical protein 2242118 yohC 4209509 yohC Shigella flexneri 5 str. 8401 hypothetical protein YP_689634.1 2241531 R 373384 CDS YP_689635.1 110806115 4209510 2242288..2242866 1 NC_008258.1 Code: S; COG: COG0586; hypothetical protein 2242866 yohD 4209510 yohD Shigella flexneri 5 str. 8401 hypothetical protein YP_689635.1 2242288 D 373384 CDS YP_689636.1 110806116 4209512 complement(2243803..2245329) 1 NC_008258.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2245329 yohG 4209512 yohG Shigella flexneri 5 str. 8401 multidrug resistance outer membrane protein MdtQ YP_689636.1 2243803 R 373384 CDS YP_689637.1 110806117 4209513 complement(2245917..2246864) 1 NC_008258.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase C 2246864 yohI 4209513 yohI Shigella flexneri 5 str. 8401 tRNA-dihydrouridine synthase C YP_689637.1 2245917 R 373384 CDS YP_689638.1 110806118 4209514 2247103..2247501 1 NC_008258.1 Code: R; COG: COG1380; hypothetical protein 2247501 yohJ 4209514 yohJ Shigella flexneri 5 str. 8401 hypothetical protein YP_689638.1 2247103 D 373384 CDS YP_689639.1 110806119 4209515 2247498..2248193 1 NC_008258.1 Code: M; COG: COG1346; hypothetical protein 2248193 yohK 4209515 yohK Shigella flexneri 5 str. 8401 hypothetical protein YP_689639.1 2247498 D 373384 CDS YP_689640.1 110806120 4209516 2248323..2249207 1 NC_008258.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2249207 cdd 4209516 cdd Shigella flexneri 5 str. 8401 cytidine deaminase YP_689640.1 2248323 D 373384 CDS YP_689641.1 110806121 4209517 2249357..2250076 1 NC_008258.1 Code: S; COG: COG2949; hypothetical protein 2250076 sanA 4209517 sanA Shigella flexneri 5 str. 8401 hypothetical protein YP_689641.1 2249357 D 373384 CDS YP_689642.1 110806122 4209518 2250079..2250318 1 NC_008258.1 hypothetical protein 2250318 4209518 SFV_2220 Shigella flexneri 5 str. 8401 hypothetical protein YP_689642.1 2250079 D 373384 CDS YP_689643.1 110806123 4209519 2250513..2251751 1 NC_008258.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2251751 4209519 SFV_2221 Shigella flexneri 5 str. 8401 oxidoreductase YP_689643.1 2250513 D 373384 CDS YP_689644.1 110806124 4209521 complement(2252994..2254004) 1 NC_008258.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane component 2254004 mglC 4209521 mglC Shigella flexneri 5 str. 8401 beta-methylgalactoside transporter inner membrane component YP_689644.1 2252994 R 373384 CDS YP_689645.1 110806125 4206744 complement(2254020..2255504) 1 NC_008258.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2255504 mglA 4206744 mglA Shigella flexneri 5 str. 8401 galactose/methyl galaxtoside transporter ATP-binding protein YP_689645.1 2254020 R 373384 CDS YP_689646.1 110806126 4206745 complement(2255601..2256599) 1 NC_008258.1 Code: G; COG: COG1879; galactose-binding transport protein; receptor for galactose taxis 2256599 mglB 4206745 mglB Shigella flexneri 5 str. 8401 galactose-binding transport protein; receptor for galactose taxis YP_689646.1 2255601 R 373384 CDS YP_689647.1 110806127 4206746 complement(2256879..2257919) 1 NC_008258.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2257919 galS 4206746 galS Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator GalS YP_689647.1 2256879 R 373384 CDS YP_689648.1 110806128 4206747 complement(2258061..2259137) 1 NC_008258.1 Code: S; COG: COG2311; hypothetical protein 2259137 yeiB 4206747 yeiB Shigella flexneri 5 str. 8401 hypothetical protein YP_689648.1 2258061 R 373384 CDS YP_689649.1 110806129 4206748 complement(2259154..2259822) 1 NC_008258.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2259822 folE 4206748 folE Shigella flexneri 5 str. 8401 GTP cyclohydrolase I YP_689649.1 2259154 R 373384 CDS YP_689650.1 110806130 4206749 2260080..2260916 1 NC_008258.1 Code: R; COG: COG0627; esterase 2260916 yeiG 4206749 yeiG Shigella flexneri 5 str. 8401 esterase YP_689650.1 2260080 D 373384 CDS YP_689651.1 110806131 4206750 complement(2260948..2262939) 1 NC_008258.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2262939 cirA 4206750 cirA Shigella flexneri 5 str. 8401 colicin I receptor YP_689651.1 2260948 R 373384 CDS YP_689652.1 110806132 4206751 complement(2263231..2264631) 1 NC_008258.1 Code: E; COG: COG0833; lysine transporter 2264631 lysP 4206751 lysP Shigella flexneri 5 str. 8401 lysine transporter YP_689652.1 2263231 R 373384 CDS YP_689653.1 110806133 4206752 complement(2264906..2265712) 1 NC_008258.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 2265712 yeiE 4206752 yeiE Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_689653.1 2264906 R 373384 CDS YP_689654.1 110806134 4206753 2265886..2266935 1 NC_008258.1 Code: S; COG: COG2855; hypothetical protein 2266935 yeiH 4206753 yeiH Shigella flexneri 5 str. 8401 hypothetical protein YP_689654.1 2265886 D 373384 CDS YP_689655.1 110806135 4206754 2267009..2267866 1 NC_008258.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2267866 nfo 4206754 nfo Shigella flexneri 5 str. 8401 endonuclease IV YP_689655.1 2267009 D 373384 CDS YP_689656.1 110806136 4206755 2267869..2268957 1 NC_008258.1 Code: G; COG: COG0524; hypothetical protein 2268957 yeiI 4206755 yeiI Shigella flexneri 5 str. 8401 hypothetical protein YP_689656.1 2267869 D 373384 CDS YP_689657.1 110806137 4206756 complement(2269013..2270263) 1 NC_008258.1 Code: F; COG: COG1972; transport system permease 2270263 yeiJ 4206756 yeiJ Shigella flexneri 5 str. 8401 transport system permease YP_689657.1 2269013 R 373384 CDS YP_689658.1 110806138 4206757 complement(2270363..2271304) 1 NC_008258.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2271304 rihB 4206757 rihB Shigella flexneri 5 str. 8401 ribonucleoside hydrolase 2 YP_689658.1 2270363 R 373384 CDS YP_689659.1 110806139 4206758 2271474..2272133 1 NC_008258.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2272133 yeiL 4206758 yeiL Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator YeiL YP_689659.1 2271474 D 373384 CDS YP_689660.1 110806140 4206759 complement(2272204..2273454) 1 NC_008258.1 Code: F; COG: COG1972; transport system permease 2273454 yeiM 4206759 yeiM Shigella flexneri 5 str. 8401 transport system permease YP_689660.1 2272204 R 373384 CDS YP_689661.1 110806141 4206760 complement(2273548..2274486) 1 NC_008258.1 Code: Q; COG: COG2313; hypothetical protein 2274486 yeiN 4206760 yeiN Shigella flexneri 5 str. 8401 hypothetical protein YP_689661.1 2273548 R 373384 CDS YP_689662.1 110806142 4206761 complement(2274474..2275415) 1 NC_008258.1 Code: G; COG: COG0524; hypothetical protein 2275415 yeiC 4206761 yeiC Shigella flexneri 5 str. 8401 hypothetical protein YP_689662.1 2274474 R 373384 CDS YP_689663.1 110806143 4206762 complement(2275839..2277530) 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunits IIBC 2277530 fruA 4206762 fruA Shigella flexneri 5 str. 8401 PTS system fructose-specific transporter subunits IIBC YP_689663.1 2275839 R 373384 CDS YP_689664.1 110806144 4206763 complement(2277547..2278485) 1 NC_008258.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2278485 fruK 4206763 fruK Shigella flexneri 5 str. 8401 1-phosphofructokinase YP_689664.1 2277547 R 373384 CDS YP_689665.1 110806145 4207566 complement(2278485..2279615) 1 NC_008258.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2279615 fruB 4207566 fruB Shigella flexneri 5 str. 8401 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_689665.1 2278485 R 373384 CDS YP_689666.1 110806146 4207567 2279983..2281161 1 NC_008258.1 Code: GEPR; COG: COG0477; transport 2281161 yeiO 4207567 yeiO Shigella flexneri 5 str. 8401 transport YP_689666.1 2279983 D 373384 CDS YP_689667.1 110806147 4207568 complement(2281155..2281550) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2281550 insB 4207568 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689667.1 2281155 R 373384 CDS YP_689668.1 110806149 4207570 complement(2281577..2281852) 1 NC_008258.1 Code: L; COG: COG3677; IS1 ORF1 2281852 insA 4207570 insA Shigella flexneri 5 str. 8401 IS1 ORF1 YP_689668.1 2281577 R 373384 CDS YP_689669.1 110806148 4207569 2281733..2281930 1 NC_008258.1 IS1 encoded protein 2281930 4207569 SFV_2247 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689669.1 2281733 D 373384 CDS YP_689670.1 110806150 4207571 2282091..2282918 1 NC_008258.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2282918 yeiP 4207571 yeiP Shigella flexneri 5 str. 8401 elongation factor P YP_689670.1 2282091 D 373384 CDS YP_689671.1 110806151 4207572 2283132..2284607 1 NC_008258.1 Code: G; COG: COG0246; oxidoreductase 2284607 yeiQ 4207572 yeiQ Shigella flexneri 5 str. 8401 oxidoreductase YP_689671.1 2283132 D 373384 CDS YP_689672.1 110806152 4207573 2284725..2285711 1 NC_008258.1 Code: R; COG: COG0523; hypothetical protein 2285711 yeiR 4207573 yeiR Shigella flexneri 5 str. 8401 hypothetical protein YP_689672.1 2284725 D 373384 CDS YP_689673.1 110806153 4207574 2285714..2286463 1 NC_008258.1 Code: I; COG: COG0671; hypothetical protein 2286463 4207574 SFV_2252 Shigella flexneri 5 str. 8401 hypothetical protein YP_689673.1 2285714 D 373384 CDS YP_689674.1 110806154 4207575 2286875..2287441 1 NC_008258.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2287441 spr 4207575 spr Shigella flexneri 5 str. 8401 outer membrane lipoprotein YP_689674.1 2286875 D 373384 CDS YP_689675.1 110806155 4207576 2287685..2289178 1 NC_008258.1 hypothetical protein 2289178 rtn 4207576 rtn Shigella flexneri 5 str. 8401 hypothetical protein YP_689675.1 2287685 D 373384 CDS YP_689676.1 110806156 4207577 2289260..2291074 1 NC_008258.1 Code: E; COG: COG4166; hypothetical protein 2291074 yejA 4207577 yejA Shigella flexneri 5 str. 8401 hypothetical protein YP_689676.1 2289260 D 373384 CDS YP_689677.1 110806157 4207578 2291075..2292169 1 NC_008258.1 Code: R; COG: COG4174; transport system permease 2292169 yejB 4207578 yejB Shigella flexneri 5 str. 8401 transport system permease YP_689677.1 2291075 D 373384 CDS YP_689678.1 110806158 4207579 2292169..2293194 1 NC_008258.1 Code: R; COG: COG4239; transport system permease 2293194 yejE 4207579 yejE Shigella flexneri 5 str. 8401 transport system permease YP_689678.1 2292169 D 373384 CDS YP_689679.1 110806159 4207580 2293196..2294785 1 NC_008258.1 Code: R; COG: COG4172; ABC transporter ATP-binding protein 2294785 yejF 4207580 yejF Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_689679.1 2293196 D 373384 CDS YP_689680.1 110806160 4207581 complement(2294789..2295133) 1 NC_008258.1 hypothetical protein 2295133 yejG 4207581 yejG Shigella flexneri 5 str. 8401 hypothetical protein YP_689680.1 2294789 R 373384 CDS YP_689681.1 110806161 4207582 complement(2295466..2296656) 1 NC_008258.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system 2296656 bcr 4207582 bcr Shigella flexneri 5 str. 8401 bicyclomycin/multidrug efflux system YP_689681.1 2295466 R 373384 CDS YP_689682.1 110806162 4207583 complement(2296684..2297475) 1 NC_008258.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2297475 rsuA 4207583 rsuA Shigella flexneri 5 str. 8401 16S rRNA pseudouridylate synthase A YP_689682.1 2296684 R 373384 CDS YP_689683.1 110806163 4207584 2297529..2299289 1 NC_008258.1 Code: KL; COG: COG1061; ATP-dependent helicase 2299289 yejH 4207584 yejH Shigella flexneri 5 str. 8401 ATP-dependent helicase YP_689683.1 2297529 D 373384 CDS YP_689684.2 229774940 4210973 2299414..2299698 1 NC_008258.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2299698 rplY 4210973 rplY Shigella flexneri 5 str. 8401 50S ribosomal protein L25 YP_689684.2 2299414 D 373384 CDS YP_689685.1 110806165 4210974 complement(2299837..2300844) 1 NC_008258.1 Code: R; COG: COG3081; nucleoid-associated protein NdpA 2300844 yejK 4210974 yejK Shigella flexneri 5 str. 8401 nucleoid-associated protein NdpA YP_689685.1 2299837 R 373384 CDS YP_689686.1 110806166 4210975 2301026..2301253 1 NC_008258.1 Code: S; COG: COG3082; hypothetical protein 2301253 yejL 4210975 yejL Shigella flexneri 5 str. 8401 hypothetical protein YP_689686.1 2301026 D 373384 CDS YP_689687.1 110806167 4210976 2301273..2303033 1 NC_008258.1 Code: R; COG: COG3083; sulfatase 2303033 yejM 4210976 yejM Shigella flexneri 5 str. 8401 sulfatase YP_689687.1 2301273 D 373384 CDS YP_689688.1 110806168 4210978 complement(2303287..2305878) 1 NC_008258.1 Code: MU; COG: COG3468; ABC transporter ATP-binding protein 2305878 yejO 4210978 yejO Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_689688.1 2303287 R 373384 CDS YP_689689.1 110806169 4210979 2306198..2306845 1 NC_008258.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2306845 narP 4210979 narP Shigella flexneri 5 str. 8401 transcriptional regulator NarP YP_689689.1 2306198 D 373384 CDS YP_689690.1 110806170 4210980 complement(2307056..2308108) 1 NC_008258.1 Code: O; COG: COG4235; subunit of heme lyase 2308108 ccmH 4210980 ccmH Shigella flexneri 5 str. 8401 subunit of heme lyase YP_689690.1 2307056 R 373384 CDS YP_689691.1 110806171 4210981 complement(2308105..2308662) 1 NC_008258.1 Code: OC; COG: COG0526; disulfide oxidoreductase 2308662 dsbE 4210981 dsbE Shigella flexneri 5 str. 8401 disulfide oxidoreductase YP_689691.1 2308105 R 373384 CDS YP_689692.1 110806172 4210982 complement(2308659..2310602) 1 NC_008258.1 Code: O; COG: COG1138; cytochrome c-type biogenesis protein 2310602 ccmF 4210982 ccmF Shigella flexneri 5 str. 8401 cytochrome c-type biogenesis protein YP_689692.1 2308659 R 373384 CDS YP_689693.1 110806173 4210983 complement(2310599..2311078) 1 NC_008258.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2311078 ccmE 4210983 ccmE Shigella flexneri 5 str. 8401 cytochrome c-type biogenesis protein CcmE YP_689693.1 2310599 R 373384 CDS YP_689694.1 110806174 4210984 complement(2311075..2311284) 1 NC_008258.1 Code: U; COG: COG3114; heme exporter protein C 2311284 ccmD 4210984 ccmD Shigella flexneri 5 str. 8401 heme exporter protein C YP_689694.1 2311075 R 373384 CDS YP_689695.1 110806175 4210985 complement(2311281..2312042) 1 NC_008258.1 Code: O; COG: COG0755; heme exporter protein C 2312042 ccmC 4210985 ccmC Shigella flexneri 5 str. 8401 heme exporter protein C YP_689695.1 2311281 R 373384 CDS YP_689696.1 110806176 4210986 complement(2312060..2312722) 1 NC_008258.1 Code: O; COG: COG2386; heme exporter protein B, cytochrome c-type biogenesis protein 2312722 ccmB 4210986 ccmB Shigella flexneri 5 str. 8401 heme exporter protein B, cytochrome c-type biogenesis protein YP_689696.1 2312060 R 373384 CDS YP_689697.1 110806177 4210987 complement(2312719..2313342) 1 NC_008258.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2313342 ccmA 4210987 ccmA Shigella flexneri 5 str. 8401 cytochrome c biogenesis protein CcmA YP_689697.1 2312719 R 373384 CDS YP_689698.1 110806178 4210988 complement(2313355..2313957) 1 NC_008258.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2313957 napC 4210988 napC Shigella flexneri 5 str. 8401 cytochrome c-type protein NapC YP_689698.1 2313355 R 373384 CDS YP_689699.1 110806179 4210989 complement(2313967..2314416) 1 NC_008258.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2314416 napB 4210989 napB Shigella flexneri 5 str. 8401 citrate reductase cytochrome c-type subunit YP_689699.1 2313967 R 373384 CDS YP_689700.1 110806180 4210990 complement(2314413..2315276) 1 NC_008258.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2315276 napH 4210990 napH Shigella flexneri 5 str. 8401 quinol dehydrogenase membrane component YP_689700.1 2314413 R 373384 CDS YP_689701.1 110806181 4210991 complement(2315263..2315958) 1 NC_008258.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2315958 napG 4210991 napG Shigella flexneri 5 str. 8401 quinol dehydrogenase periplasmic component YP_689701.1 2315263 R 373384 CDS YP_689702.1 110806182 4210767 complement(2315965..2318451) 1 NC_008258.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2318451 napA 4210767 napA Shigella flexneri 5 str. 8401 nitrate reductase catalytic subunit YP_689702.1 2315965 R 373384 CDS YP_689703.1 110806183 4210768 complement(2318448..2318711) 1 NC_008258.1 Code: P; COG: COG3062; assembly protein for periplasmic nitrate reductase 2318711 napD 4210768 napD Shigella flexneri 5 str. 8401 assembly protein for periplasmic nitrate reductase YP_689703.1 2318448 R 373384 CDS YP_689704.1 110806184 4210769 2319603..2320091 1 NC_008258.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2320091 eco 4210769 eco Shigella flexneri 5 str. 8401 ecotin YP_689704.1 2319603 D 373384 CDS YP_689705.1 110806185 4210771 complement(2322083..2323726) 1 NC_008258.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane component/ATP-binding protein 2323726 yojI 4210771 yojI Shigella flexneri 5 str. 8401 multidrug transporter membrane component/ATP-binding protein YP_689705.1 2322083 R 373384 CDS YP_689706.1 110806186 4210772 complement(2323802..2324452) 1 NC_008258.1 Code: L; COG: COG3145; alkylated DNA repair protein 2324452 alkB 4210772 alkB Shigella flexneri 5 str. 8401 alkylated DNA repair protein YP_689706.1 2323802 R 373384 CDS YP_689707.1 110806187 4210773 complement(2324452..2325516) 1 NC_008258.1 O6-methylguanine-DNA methyltransferase; transcription activator/repressor 2325516 ada 4210773 ada Shigella flexneri 5 str. 8401 O6-methylguanine-DNA methyltransferase; transcription activator/repressor YP_689707.1 2324452 R 373384 CDS YP_689708.1 110806188 4210774 complement(2325590..2326645) 1 NC_008258.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2326645 yojL 4210774 yojL Shigella flexneri 5 str. 8401 thiamine biosynthesis lipoprotein ApbE YP_689708.1 2325590 R 373384 CDS YP_689709.1 110806189 4210775 complement(2326757..2327878) 1 NC_008258.1 allows for ions and hydrophilic solutes to cross the outer membrane; porin 2327878 ompC 4210775 ompC Shigella flexneri 5 str. 8401 porin YP_689709.1 2326757 R 373384 CDS YP_689710.1 110806190 4210776 2328709..2331288 1 NC_008258.1 Code: T; COG: COG0642; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2331288 yojN 4210776 yojN Shigella flexneri 5 str. 8401 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_689710.1 2328709 D 373384 CDS YP_689711.1 110806191 4210777 2331305..2331955 1 NC_008258.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2331955 rcsB 4210777 rcsB Shigella flexneri 5 str. 8401 transcriptional regulator RcsB YP_689711.1 2331305 D 373384 CDS YP_689712.1 110806192 4210778 complement(2332155..2335004) 1 NC_008258.1 Code: T; COG: COG0642; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2335004 rcsC 4210778 rcsC Shigella flexneri 5 str. 8401 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_689712.1 2332155 R 373384 CDS YP_689713.1 110806193 4210779 complement(2335279..2336055) 1 NC_008258.1 Code: S; COG: COG4676; hypothetical protein 2336055 4210779 SFV_2294 Shigella flexneri 5 str. 8401 hypothetical protein YP_689713.1 2335279 R 373384 CDS YP_689714.1 110806194 4210780 complement(2336060..2337631) 1 NC_008258.1 Code: S; COG: COG5445; hypothetical protein 2337631 4210780 SFV_2295 Shigella flexneri 5 str. 8401 hypothetical protein YP_689714.1 2336060 R 373384 CDS YP_689715.1 110806195 4210781 complement(2339983..2340822) 1 NC_008258.1 Code: L; COG: COG2801; IS911 ORF2 2340822 4210781 SFV_2296 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_689715.1 2339983 R 373384 CDS YP_689716.1 110806196 4210782 complement(2340849..2341151) 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 2341151 4210782 SFV_2297 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_689716.1 2340849 R 373384 CDS YP_689717.1 110806197 4210784 complement(2343500..2344123) 1 NC_008258.1 Code: S; COG: COG3234; hypothetical protein 2344123 4210784 SFV_2299 Shigella flexneri 5 str. 8401 hypothetical protein YP_689717.1 2343500 R 373384 CDS YP_689718.1 110806198 4210785 complement(2344120..2345241) 1 NC_008258.1 Code: S; COG: COG4685; hypothetical protein 2345241 4210785 SFV_2300 Shigella flexneri 5 str. 8401 hypothetical protein YP_689718.1 2344120 R 373384 CDS YP_689719.1 110806199 4211102 complement(2345302..2345808) 1 NC_008258.1 hypothetical protein 2345808 4211102 SFV_2301 Shigella flexneri 5 str. 8401 hypothetical protein YP_689719.1 2345302 R 373384 CDS YP_689720.1 110806200 4211103 complement(2345957..2348584) 1 NC_008258.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2348584 gyrA 4211103 gyrA Shigella flexneri 5 str. 8401 DNA gyrase subunit A YP_689720.1 2345957 R 373384 CDS YP_689721.1 110806201 4211104 2348731..2349453 1 NC_008258.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2349453 ubiG 4211104 ubiG Shigella flexneri 5 str. 8401 3-demethylubiquinone-9 3-methyltransferase YP_689721.1 2348731 D 373384 CDS YP_689722.1 110806202 4211105 2353250..2353615 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2353615 4211105 SFV_2304 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689722.1 2353250 D 373384 CDS YP_689723.2 162139334 4211106 2353573..2354478 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2354478 4211106 SFV_2305 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_689723.2 2353573 D 373384 CDS YP_689724.1 110806204 4211108 2355365..2357650 1 NC_008258.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2357650 nrdA 4211108 nrdA Shigella flexneri 5 str. 8401 ribonucleotide-diphosphate reductase subunit alpha YP_689724.1 2355365 D 373384 CDS YP_689725.1 110806205 4211109 2357653..2359014 1 NC_008258.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2359014 nrdB 4211109 nrdB Shigella flexneri 5 str. 8401 ribonucleotide-diphosphate reductase subunit beta YP_689725.1 2357653 D 373384 CDS YP_689726.1 110806206 4211110 2359014..2359268 1 NC_008258.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2359268 yfaE 4211110 yfaE Shigella flexneri 5 str. 8401 2Fe-2S ferredoxin YP_689726.1 2359014 D 373384 CDS YP_689727.1 110806207 4211111 complement(2359322..2359972) 1 NC_008258.1 hypothetical protein 2359972 inaA 4211111 inaA Shigella flexneri 5 str. 8401 hypothetical protein YP_689727.1 2359322 R 373384 CDS YP_689728.1 110806208 4211112 complement(2360435..2361511) 1 NC_008258.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2361511 glpQ 4211112 glpQ Shigella flexneri 5 str. 8401 glycerophosphodiester phosphodiesterase YP_689728.1 2360435 R 373384 CDS YP_689729.1 110806209 4211113 complement(2361516..2362874) 1 NC_008258.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2362874 glpT 4211113 glpT Shigella flexneri 5 str. 8401 sn-glycerol-3-phosphate transporter YP_689729.1 2361516 R 373384 CDS YP_689730.1 110806210 4211114 2363147..2364775 1 NC_008258.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2364775 glpA 4211114 glpA Shigella flexneri 5 str. 8401 sn-glycerol-3-phosphate dehydrogenase subunit A YP_689730.1 2363147 D 373384 CDS YP_689731.1 110806211 4211115 2364765..2366024 1 NC_008258.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2366024 glpB 4211115 glpB Shigella flexneri 5 str. 8401 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_689731.1 2364765 D 373384 CDS YP_689732.1 110806212 4211116 2366021..2367211 1 NC_008258.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2367211 glpC 4211116 glpC Shigella flexneri 5 str. 8401 sn-glycerol-3-phosphate dehydrogenase subunit C YP_689732.1 2366021 D 373384 CDS YP_689733.1 110806213 4211117 2367404..2368354 1 NC_008258.1 Code: S; COG: COG5464; hypothetical protein 2368354 yfaD 4211117 yfaD Shigella flexneri 5 str. 8401 hypothetical protein YP_689733.1 2367404 D 373384 CDS YP_689734.1 110806214 4211118 complement(2368395..2368907) 1 NC_008258.1 hypothetical protein 2368907 4211118 SFV_2317 Shigella flexneri 5 str. 8401 hypothetical protein YP_689734.1 2368395 R 373384 CDS YP_689735.1 110806215 4211119 complement(2368920..2369249) 1 NC_008258.1 hypothetical protein 2369249 4211119 SFV_2318 Shigella flexneri 5 str. 8401 hypothetical protein YP_689735.1 2368920 R 373384 CDS YP_689736.1 110806216 4211120 complement(2369331..2370122) 1 NC_008258.1 Code: R; COG: COG1058; hypothetical protein 2370122 4211120 SFV_2319 Shigella flexneri 5 str. 8401 hypothetical protein YP_689736.1 2369331 R 373384 CDS YP_689737.1 110806217 4211121 complement(2370209..2370751) 1 NC_008258.1 hypothetical protein 2370751 4211121 SFV_2320 Shigella flexneri 5 str. 8401 hypothetical protein YP_689737.1 2370209 R 373384 CDS YP_689738.1 110806218 4210268 2370946..2371455 1 NC_008258.1 Code: LR; COG: COG0494; hypothetical protein 2371455 yfaO 4210268 yfaO Shigella flexneri 5 str. 8401 hypothetical protein YP_689738.1 2370946 D 373384 CDS YP_689739.1 110806219 4210269 complement(2371494..2372153) 1 NC_008258.1 protein induced by aluminum 2372153 ais 4210269 ais Shigella flexneri 5 str. 8401 protein induced by aluminum YP_689739.1 2371494 R 373384 CDS YP_689740.1 110806220 4210270 2372404..2373543 1 NC_008258.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2373543 4210270 SFV_2323 Shigella flexneri 5 str. 8401 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_689740.1 2372404 D 373384 CDS YP_689741.1 110806221 4210271 2373547..2374515 1 NC_008258.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2374515 4210271 SFV_2324 Shigella flexneri 5 str. 8401 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_689741.1 2373547 D 373384 CDS YP_689742.1 110806222 4210272 2374515..2376497 1 NC_008258.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2376497 4210272 SFV_2325 Shigella flexneri 5 str. 8401 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_689742.1 2374515 D 373384 CDS YP_689743.1 110806223 4210273 2376494..2377384 1 NC_008258.1 Code: G; COG: COG0726; hypothetical protein 2377384 4210273 SFV_2326 Shigella flexneri 5 str. 8401 hypothetical protein YP_689743.1 2376494 D 373384 CDS YP_689744.2 162139333 4210274 2377384..2379036 1 NC_008258.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2379036 arnT 4210274 arnT Shigella flexneri 5 str. 8401 4-amino-4-deoxy-L-arabinose transferase YP_689744.2 2377384 D 373384 CDS YP_689745.1 110806225 4210275 2379033..2379368 1 NC_008258.1 Code: GER; COG: COG0697; sucrose-6 phosphate hydrolase 2379368 4210275 SFV_2328 Shigella flexneri 5 str. 8401 sucrose-6 phosphate hydrolase YP_689745.1 2379033 D 373384 CDS YP_689746.1 110806226 4210276 2379368..2379754 1 NC_008258.1 hypothetical protein 2379754 4210276 SFV_2329 Shigella flexneri 5 str. 8401 hypothetical protein YP_689746.1 2379368 D 373384 CDS YP_689747.1 110806227 4210278 complement(2380125..2381480) 1 NC_008258.1 Code: IQ; COG: COG0318; O-succinylbenzoic acid--CoA ligase 2381480 menE 4210278 menE Shigella flexneri 5 str. 8401 O-succinylbenzoic acid--CoA ligase YP_689747.1 2380125 R 373384 CDS YP_689748.1 110806228 4210279 complement(2381477..2382403) 1 NC_008258.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2382403 menC 4210279 menC Shigella flexneri 5 str. 8401 O-succinylbenzoate synthase YP_689748.1 2381477 R 373384 CDS YP_689749.1 110806229 4210280 complement(2382439..2383296) 1 NC_008258.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2383296 menB 4210280 menB Shigella flexneri 5 str. 8401 naphthoate synthase YP_689749.1 2382439 R 373384 CDS YP_689750.1 110806230 4210281 complement(2383311..2384069) 1 NC_008258.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase 2384069 yfbB 4210281 yfbB Shigella flexneri 5 str. 8401 acyl-CoA thioester hydrolase YP_689750.1 2383311 R 373384 CDS YP_689751.1 110806231 4210282 complement(2384066..2385925) 1 NC_008258.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2385925 menD 4210282 menD Shigella flexneri 5 str. 8401 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_689751.1 2384066 R 373384 CDS YP_689752.1 110806232 4210283 complement(2385825..2387120) 1 NC_008258.1 Code: HQ; COG: COG1169; menaquinone-specific isochorismate synthase 2387120 menF 4210283 menF Shigella flexneri 5 str. 8401 menaquinone-specific isochorismate synthase YP_689752.1 2385825 R 373384 CDS YP_689753.1 110806233 4210284 complement(2387199..2387504) 1 NC_008258.1 Code: S; COG: COG4575; hypothetical protein 2387504 elaB 4210284 elaB Shigella flexneri 5 str. 8401 hypothetical protein YP_689753.1 2387199 R 373384 CDS YP_689754.1 110806234 4210285 complement(2387559..2388020) 1 NC_008258.1 Code: R; COG: COG2153; hypothetical protein 2388020 elaA 4210285 elaA Shigella flexneri 5 str. 8401 hypothetical protein YP_689754.1 2387559 R 373384 CDS YP_689755.1 110806235 4210286 2388067..2389002 1 NC_008258.1 member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2389002 elaC 4210286 elaC Shigella flexneri 5 str. 8401 ribonuclease Z YP_689755.1 2388067 D 373384 CDS YP_689756.1 110806236 4210933 complement(2389357..2389557) 1 NC_008258.1 IS1 encoded protein 2389557 4210933 SFV_2340 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_689756.1 2389357 R 373384 CDS YP_689757.1 110806237 4210934 2389632..2390135 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2390135 insB 4210934 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689757.1 2389632 D 373384 CDS YP_689758.1 110806238 4210935 2390219..2390647 1 NC_008258.1 hypothetical protein 2390647 yfbM 4210935 yfbM Shigella flexneri 5 str. 8401 hypothetical protein YP_689758.1 2390219 D 373384 CDS YP_689759.1 110806239 4210936 complement(2390714..2391991) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2391991 nuoN 4210936 nuoN Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit N YP_689759.1 2390714 R 373384 CDS YP_689760.1 110806240 4210937 complement(2392178..2393707) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2393707 nuoM 4210937 nuoM Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit M YP_689760.1 2392178 R 373384 CDS YP_689761.1 110806241 4210938 complement(2393871..2395712) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2395712 nuoL 4210938 nuoL Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit L YP_689761.1 2393871 R 373384 CDS YP_689762.1 110806242 4210939 complement(2395709..2396011) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2396011 nuoK 4210939 nuoK Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit K YP_689762.1 2395709 R 373384 CDS YP_689763.1 110806243 4210940 complement(2396008..2396562) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2396562 nuoJ 4210940 nuoJ Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit J YP_689763.1 2396008 R 373384 CDS YP_689764.1 110806244 4210941 complement(2396574..2397116) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2397116 nuoI 4210941 nuoI Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit I YP_689764.1 2396574 R 373384 CDS YP_689765.1 110806245 4210942 complement(2397131..2398108) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2398108 nuoH 4210942 nuoH Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit H YP_689765.1 2397131 R 373384 CDS YP_689766.1 110806246 4210943 complement(2398105..2400831) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2400831 nuoG 4210943 nuoG Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit G YP_689766.1 2398105 R 373384 CDS YP_689767.1 110806247 4210944 complement(2400884..2402221) 1 NC_008258.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2402221 nuoF 4210944 nuoF Shigella flexneri 5 str. 8401 NADH dehydrogenase I subunit F YP_689767.1 2400884 R 373384 CDS YP_689768.1 110806248 4210945 complement(2402218..2402718) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2402718 nuoE 4210945 nuoE Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit E YP_689768.1 2402218 R 373384 CDS YP_689769.1 110806249 4210946 complement(2402721..2404511) 1 NC_008258.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2404511 nuoC 4210946 nuoC Shigella flexneri 5 str. 8401 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_689769.1 2402721 R 373384 CDS YP_689770.1 110806250 4210947 complement(2404617..2405279) 1 NC_008258.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2405279 nuoB 4210947 nuoB Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit B YP_689770.1 2404617 R 373384 CDS YP_689771.1 110806251 4210948 complement(2405295..2405738) 1 NC_008258.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2405738 nuoA 4210948 nuoA Shigella flexneri 5 str. 8401 NADH dehydrogenase subunit A YP_689771.1 2405295 R 373384 CDS YP_689772.1 110806252 4210949 complement(2406370..2407308) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2407308 lrhA 4210949 lrhA Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_689772.1 2406370 R 373384 CDS YP_689773.1 110806253 4210950 2408233..2409450 1 NC_008258.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2409450 4210950 SFV_2357 Shigella flexneri 5 str. 8401 aminotransferase YP_689773.1 2408233 D 373384 CDS YP_689774.1 110806254 4210951 2409534..2410133 1 NC_008258.1 Code: R; COG: COG1896; hypothetical protein 2410133 4210951 SFV_2358 Shigella flexneri 5 str. 8401 hypothetical protein YP_689774.1 2409534 D 373384 CDS YP_689775.1 110806255 4210952 complement(2410192..2411949) 1 NC_008258.1 Code: P; COG: COG0471; transport protein 2411949 yfbS 4210952 yfbS Shigella flexneri 5 str. 8401 transport protein YP_689775.1 2410192 R 373384 CDS YP_689776.1 110806256 4207024 complement(2412111..2412761) 1 NC_008258.1 Code: R; COG: COG0637; phosphatase 2412761 yfbT 4207024 yfbT Shigella flexneri 5 str. 8401 phosphatase YP_689776.1 2412111 R 373384 CDS YP_689777.1 110806257 4207025 complement(2412772..2413266) 1 NC_008258.1 Code: S; COG: COG3013; hypothetical protein 2413266 4207025 SFV_2361 Shigella flexneri 5 str. 8401 hypothetical protein YP_689777.1 2412772 R 373384 CDS YP_689778.1 110806258 4207026 complement(2413349..2413804) 1 NC_008258.1 Code: S; COG: COG3092; hypothetical protein 2413804 4207026 SFV_2362 Shigella flexneri 5 str. 8401 hypothetical protein YP_689778.1 2413349 R 373384 CDS YP_689779.1 110806259 4207027 2414142..2415344 1 NC_008258.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2415344 ackA 4207027 ackA Shigella flexneri 5 str. 8401 acetate kinase YP_689779.1 2414142 D 373384 CDS YP_689780.1 110806260 4207028 2415419..2417563 1 NC_008258.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2417563 pta 4207028 pta Shigella flexneri 5 str. 8401 phosphate acetyltransferase YP_689780.1 2415419 D 373384 CDS YP_689781.1 110806261 4207029 2417795..2419273 1 NC_008258.1 Code: S; COG: COG1288; hypothetical protein 2419273 yfcC 4207029 yfcC Shigella flexneri 5 str. 8401 hypothetical protein YP_689781.1 2417795 D 373384 CDS YP_689782.1 110806262 4207030 complement(2419306..2419848) 1 NC_008258.1 Code: LR; COG: COG0494; regulator 2419848 4207030 SFV_2366 Shigella flexneri 5 str. 8401 regulator YP_689782.1 2419306 R 373384 CDS YP_689783.1 110806263 4207031 complement(2419906..2420457) 1 NC_008258.1 Code: R; COG: COG0622; phosphodiesterase 2420457 yfcE 4207031 yfcE Shigella flexneri 5 str. 8401 phosphodiesterase YP_689783.1 2419906 R 373384 CDS YP_689784.1 110806264 4207032 complement(2420513..2421157) 1 NC_008258.1 Code: O; COG: COG0625; hypothetical protein 2421157 yfcF 4207032 yfcF Shigella flexneri 5 str. 8401 hypothetical protein YP_689784.1 2420513 R 373384 CDS YP_689785.1 110806265 4207033 2421293..2421940 1 NC_008258.1 Code: O; COG: COG0625; glutathione S-transferase 2421940 yfcG 4207033 yfcG Shigella flexneri 5 str. 8401 glutathione S-transferase YP_689785.1 2421293 D 373384 CDS YP_689786.1 110806266 4207034 2421997..2422359 1 NC_008258.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2422359 folX 4207034 folX Shigella flexneri 5 str. 8401 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_689786.1 2421997 D 373384 CDS YP_689787.1 110806267 4207035 2422380..2423273 1 NC_008258.1 Code: R; COG: COG1090; sugar nucleotide epimerase 2423273 4207035 SFV_2371 Shigella flexneri 5 str. 8401 sugar nucleotide epimerase YP_689787.1 2422380 D 373384 CDS YP_689788.1 110806268 4207036 complement(2423321..2424211) 1 NC_008258.1 Code: S; COG: COG5464; hypothetical protein 2424211 yfcI 4207036 yfcI Shigella flexneri 5 str. 8401 hypothetical protein YP_689788.1 2423321 R 373384 CDS YP_689789.1 110806269 4207037 complement(2424408..2425181) 1 NC_008258.1 Code: E; COG: COG4598; histidine/lysine/arginine/ornithine transporter subunit 2425181 hisP 4207037 hisP Shigella flexneri 5 str. 8401 histidine/lysine/arginine/ornithine transporter subunit YP_689789.1 2424408 R 373384 CDS YP_689790.1 110806270 4207038 complement(2425189..2425905) 1 NC_008258.1 Code: E; COG: COG4160; histidine transport, membrane protein M 2425905 hisM 4207038 hisM Shigella flexneri 5 str. 8401 histidine transport, membrane protein M YP_689790.1 2425189 R 373384 CDS YP_689791.1 110806271 4207039 complement(2425902..2426588) 1 NC_008258.1 Code: E; COG: COG4215; histidine transport system permease 2426588 hisQ 4207039 hisQ Shigella flexneri 5 str. 8401 histidine transport system permease YP_689791.1 2425902 R 373384 CDS YP_689792.1 110806272 4207040 complement(2426678..2427460) 1 NC_008258.1 Code: ET; COG: COG0834; histidine-binding periplasmic protein of high-affinity histidine transport system 2427460 hisJ 4207040 hisJ Shigella flexneri 5 str. 8401 histidine-binding periplasmic protein of high-affinity histidine transport system YP_689792.1 2426678 R 373384 CDS YP_689793.1 110806273 4207041 complement(2427681..2428382) 1 NC_008258.1 Code: ET; COG: COG0834; lysine-, arginine-, ornithine-binding periplasmic protein 2428382 argT 4207041 argT Shigella flexneri 5 str. 8401 lysine-, arginine-, ornithine-binding periplasmic protein YP_689793.1 2427681 R 373384 CDS YP_689794.2 162139332 4207042 complement(2428367..2429272) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2429272 4207042 SFV_2378 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_689794.2 2428367 R 373384 CDS YP_689795.1 110806275 4206879 complement(2429230..2429640) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2429640 4206879 SFV_2379 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689795.1 2429230 R 373384 CDS YP_689796.1 110806276 4206880 complement(2430065..2430634) 1 NC_008258.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2430634 ubiX 4206880 ubiX Shigella flexneri 5 str. 8401 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_689796.1 2430065 R 373384 CDS YP_689797.1 110806277 4206881 complement(2430730..2432247) 1 NC_008258.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2432247 purF 4206881 purF Shigella flexneri 5 str. 8401 amidophosphoribosyltransferase YP_689797.1 2430730 R 373384 CDS YP_689798.1 110806278 4206882 complement(2432284..2432772) 1 NC_008258.1 membrane protein required for colicin V production; colicin V production protein 2432772 cvpA 4206882 cvpA Shigella flexneri 5 str. 8401 colicin V production protein YP_689798.1 2432284 R 373384 CDS YP_689799.1 110806279 4206883 complement(2433031..2433693) 1 NC_008258.1 Code: S; COG: COG3147; hypothetical protein 2433693 dedD 4206883 dedD Shigella flexneri 5 str. 8401 hypothetical protein YP_689799.1 2433031 R 373384 CDS YP_689800.1 110806280 4206884 complement(2433683..2434951) 1 NC_008258.1 Code: H; COG: COG0285; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2434951 folC 4206884 folC Shigella flexneri 5 str. 8401 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_689800.1 2433683 R 373384 CDS YP_689801.1 110806281 4206885 complement(2435021..2435935) 1 NC_008258.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2435935 accD 4206885 accD Shigella flexneri 5 str. 8401 acetyl-CoA carboxylase subunit beta YP_689801.1 2435021 R 373384 CDS YP_689802.1 110806282 4206886 complement(2436091..2436750) 1 NC_008258.1 Code: S; COG: COG0586; hypothetical protein 2436750 dedA 4206886 dedA Shigella flexneri 5 str. 8401 hypothetical protein YP_689802.1 2436091 R 373384 CDS YP_689803.1 110806283 4206887 complement(2436833..2437645) 1 NC_008258.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2437645 truA 4206887 truA Shigella flexneri 5 str. 8401 tRNA pseudouridine synthase A YP_689803.1 2436833 R 373384 CDS YP_689804.1 110806284 4206888 complement(2437645..2438658) 1 NC_008258.1 Code: E; COG: COG0136; semialdehyde dehydrogenase 2438658 usg 4206888 usg Shigella flexneri 5 str. 8401 semialdehyde dehydrogenase YP_689804.1 2437645 R 373384 CDS YP_689805.1 110806285 4206889 complement(2438724..2439860) 1 NC_008258.1 Code: HE; COG: COG0111; erythronate-4-phosphate dehydrogenase 2439860 pdxB 4206889 pdxB Shigella flexneri 5 str. 8401 erythronate-4-phosphate dehydrogenase YP_689805.1 2438724 R 373384 CDS YP_689806.1 110806286 4206890 2439959..2440954 1 NC_008258.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2440954 flk 4206890 flk Shigella flexneri 5 str. 8401 flagella biosynthesis regulator YP_689806.1 2439959 D 373384 CDS YP_689807.1 110806287 4206891 complement(2440951..2442129) 1 NC_008258.1 Code: GEPR; COG: COG0477; hypothetical protein 2442129 4206891 SFV_2391 Shigella flexneri 5 str. 8401 hypothetical protein YP_689807.1 2440951 R 373384 CDS YP_689808.1 110806288 4206892 complement(2442384..2443496) 1 NC_008258.1 Code: IQ; COG: COG0304; 3-oxoacyl-ACP synthase 2443496 fabB 4206892 fabB Shigella flexneri 5 str. 8401 3-oxoacyl-ACP synthase YP_689808.1 2442384 R 373384 CDS YP_689809.1 110806289 4206893 2443784..2445790 1 NC_008258.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2445790 mnmC 4206893 mnmC Shigella flexneri 5 str. 8401 5-methylaminomethyl-2-thiouridine methyltransferase YP_689809.1 2443784 D 373384 CDS YP_689810.1 110806290 4206894 complement(2445911..2446189) 1 NC_008258.1 hypothetical protein 2446189 4206894 SFV_2394 Shigella flexneri 5 str. 8401 hypothetical protein YP_689810.1 2445911 R 373384 CDS YP_689811.1 110806291 4206895 complement(2446223..2446771) 1 NC_008258.1 Code: S; COG: COG3101; transporting ATPase 2446771 4206895 SFV_2395 Shigella flexneri 5 str. 8401 transporting ATPase YP_689811.1 2446223 R 373384 CDS YP_689812.1 110806292 4206896 complement(2446771..2447514) 1 NC_008258.1 Code: R; COG: COG0730; hypothetical protein 2447514 yfcA 4206896 yfcA Shigella flexneri 5 str. 8401 hypothetical protein YP_689812.1 2446771 R 373384 CDS YP_689813.1 110806293 4206897 complement(2447580..2448404) 1 NC_008258.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2448404 mepA 4206897 mepA Shigella flexneri 5 str. 8401 penicillin-insensitive murein endopeptidase YP_689813.1 2447580 R 373384 CDS YP_689814.1 110806294 4206898 complement(2448408..2449493) 1 NC_008258.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2449493 aroC 4206898 aroC Shigella flexneri 5 str. 8401 chorismate synthase YP_689814.1 2448408 R 373384 CDS YP_689815.1 110806296 4207229 complement(2449528..2450793) 1 NC_008258.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2450793 yfcB 4207229 yfcB Shigella flexneri 5 str. 8401 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_689815.1 2449528 R 373384 CDS YP_689816.1 110806295 4207228 2450626..2451177 1 NC_008258.1 Code: S; COG: COG2840; hypothetical protein 2451177 4207228 SFV_2399 Shigella flexneri 5 str. 8401 hypothetical protein YP_689816.1 2450626 D 373384 CDS YP_689817.1 110806297 4207230 complement(2451281..2452066) 1 NC_008258.1 hypothetical protein 2452066 yfcO 4207230 yfcO Shigella flexneri 5 str. 8401 hypothetical protein YP_689817.1 2451281 R 373384 CDS YP_689818.1 110806298 4207231 complement(2452158..2452682) 1 NC_008258.1 Code: NU; COG: COG3539; minor fimbrial subunit 2452682 4207231 SFV_2402 Shigella flexneri 5 str. 8401 minor fimbrial subunit YP_689818.1 2452158 R 373384 CDS YP_689819.1 110806299 4207232 complement(2452679..2453149) 1 NC_008258.1 Code: NU; COG: COG3539; minor fimbrial subunit 2453149 4207232 SFV_2403 Shigella flexneri 5 str. 8401 minor fimbrial subunit YP_689819.1 2452679 R 373384 CDS YP_689820.1 110806300 4207233 complement(2453146..2453652) 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial protein 2453652 4207233 SFV_2404 Shigella flexneri 5 str. 8401 fimbrial protein YP_689820.1 2453146 R 373384 CDS YP_689821.1 110806301 4207234 complement(2453699..2454421) 1 NC_008258.1 Code: NU; COG: COG3121; chaperone 2454421 yfcS 4207234 yfcS Shigella flexneri 5 str. 8401 chaperone YP_689821.1 2453699 R 373384 CDS YP_689822.1 110806302 4207236 complement(2457164..2457727) 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial-like protein 2457727 4207236 SFV_2407 Shigella flexneri 5 str. 8401 fimbrial-like protein YP_689822.1 2457164 R 373384 CDS YP_689823.1 110806303 4207237 complement(2458411..2458896) 1 NC_008258.1 Code: T; COG: COG2062; phosphohistidine phosphatase 2458896 4207237 SFV_2408 Shigella flexneri 5 str. 8401 phosphohistidine phosphatase YP_689823.1 2458411 R 373384 CDS YP_689824.1 110806304 4207238 complement(2459099..2461243) 1 NC_008258.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2461243 fadJ 4207238 fadJ Shigella flexneri 5 str. 8401 multifunctional fatty acid oxidation complex subunit alpha YP_689824.1 2459099 R 373384 CDS YP_689825.1 110806305 4207239 complement(2461243..2462553) 1 NC_008258.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2462553 fadI 4207239 fadI Shigella flexneri 5 str. 8401 3-ketoacyl-CoA thiolase YP_689825.1 2461243 R 373384 CDS YP_689826.1 110806306 4207240 complement(2462733..2463017) 1 NC_008258.1 Code: S; COG: COG3691; hypothetical protein 2463017 4207240 SFV_2411 Shigella flexneri 5 str. 8401 hypothetical protein YP_689826.1 2462733 R 373384 CDS YP_689827.1 110806307 4207241 2463383..2464729 1 NC_008258.1 Code: I; COG: COG2067; long-chain fatty acid outer membrane transporter 2464729 fadL 4207241 fadL Shigella flexneri 5 str. 8401 long-chain fatty acid outer membrane transporter YP_689827.1 2463383 D 373384 CDS YP_689828.1 110806308 4207242 2465095..2466153 1 NC_008258.1 hypothetical protein 2466153 4207242 SFV_2413 Shigella flexneri 5 str. 8401 hypothetical protein YP_689828.1 2465095 D 373384 CDS YP_689829.1 110806309 4207243 complement(2466335..2467090) 1 NC_008258.1 Code: M; COG: COG2853; lipoprotein 2467090 vacJ 4207243 vacJ Shigella flexneri 5 str. 8401 lipoprotein YP_689829.1 2466335 R 373384 CDS YP_689830.1 110806310 4207244 2467384..2468316 1 NC_008258.1 Code: P; COG: COG2116; transport protein 2468316 yfdC 4207244 yfdC Shigella flexneri 5 str. 8401 transport protein YP_689830.1 2467384 D 373384 CDS YP_689831.1 110806311 4209541 2468626..2469120 1 NC_008258.1 integrase 2469120 4209541 SFV_2417 Shigella flexneri 5 str. 8401 integrase YP_689831.1 2468626 D 373384 CDS YP_689832.1 110806312 4209542 complement(2469095..2469661) 1 NC_008258.1 IS911 ORF2 2469661 4209542 SFV_2418 Shigella flexneri 5 str. 8401 IS911 ORF2 YP_689832.1 2469095 R 373384 CDS YP_689833.1 110806313 4209543 complement(2469962..2470264) 1 NC_008258.1 Code: L; COG: COG2963; IS911 ORF1 2470264 4209543 SFV_2419 Shigella flexneri 5 str. 8401 IS911 ORF1 YP_689833.1 2469962 R 373384 CDS YP_689834.1 110806314 4209544 complement(2470534..2471403) 1 NC_008258.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 2471403 4209544 SFV_2420 Shigella flexneri 5 str. 8401 aminoimidazole riboside kinase YP_689834.1 2470534 R 373384 CDS YP_689835.1 110806315 4209545 complement(2471454..2472803) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 2472803 4209545 SFV_2421 Shigella flexneri 5 str. 8401 IS4 orf YP_689835.1 2471454 R 373384 CDS YP_689836.1 110806316 4209546 2473101..2474534 1 NC_008258.1 Code: G; COG: COG1621; hypothetical protein 2474534 4209546 SFV_2422 Shigella flexneri 5 str. 8401 hypothetical protein YP_689836.1 2473101 D 373384 CDS YP_689837.1 110806317 4209547 complement(2474542..2475495) 1 NC_008258.1 Code: K; COG: COG1609; sucrose specific repressor 2475495 4209547 SFV_2423 Shigella flexneri 5 str. 8401 sucrose specific repressor YP_689837.1 2474542 R 373384 CDS YP_689838.1 110806318 4209548 2475768..2475986 1 NC_008258.1 D-serine permease 2475986 4209548 SFV_2424 Shigella flexneri 5 str. 8401 D-serine permease YP_689838.1 2475768 D 373384 CDS YP_689839.1 110806319 4209549 2476004..2477332 1 NC_008258.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2477332 dsdA 4209549 dsdA Shigella flexneri 5 str. 8401 D-serine dehydratase YP_689839.1 2476004 D 373384 CDS YP_689840.1 110806320 4209550 complement(2477440..2478978) 1 NC_008258.1 Code: GEPR; COG: COG0477; multidrug resistance protein Y 2478978 emrY 4209550 emrY Shigella flexneri 5 str. 8401 multidrug resistance protein Y YP_689840.1 2477440 R 373384 CDS YP_689841.1 110806321 4209551 complement(2478978..2480141) 1 NC_008258.1 Code: V; COG: COG1566; multidrug resistance protein K 2480141 emrK 4209551 emrK Shigella flexneri 5 str. 8401 multidrug resistance protein K YP_689841.1 2478978 R 373384 CDS YP_689842.1 110806322 4209552 2480558..2481172 1 NC_008258.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2481172 evgA 4209552 evgA Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator EvgA YP_689842.1 2480558 D 373384 CDS YP_689843.1 110806323 4209553 2481177..2484770 1 NC_008258.1 hybrid sensory histidine kinase in two-component regulatory system with EvgA 2484770 evgS 4209553 evgS Shigella flexneri 5 str. 8401 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_689843.1 2481177 D 373384 CDS YP_689844.1 110806324 4209554 complement(2484826..2486010) 1 NC_008258.1 Code: C; COG: COG1804; hypothetical protein 2486010 yfdE 4209554 yfdE Shigella flexneri 5 str. 8401 hypothetical protein YP_689844.1 2484826 R 373384 CDS YP_689845.1 110806325 4209555 complement(2486045..2486989) 1 NC_008258.1 member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV 2486989 4209555 SFV_2431 Shigella flexneri 5 str. 8401 transporter YfdV YP_689845.1 2486045 R 373384 CDS YP_689846.1 110806326 4209556 complement(2487059..2488753) 1 NC_008258.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 2488753 4209556 SFV_2432 Shigella flexneri 5 str. 8401 oxalyl-CoA decarboxylase YP_689846.1 2487059 R 373384 CDS YP_689847.1 110806327 4209557 complement(2488807..2490057) 1 NC_008258.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2490057 4209557 SFV_2433 Shigella flexneri 5 str. 8401 formyl-coenzyme A transferase YP_689847.1 2488807 R 373384 CDS YP_689848.1 110806328 4209558 complement(2490570..2491193) 1 NC_008258.1 hypothetical protein 2491193 4209558 SFV_2434 Shigella flexneri 5 str. 8401 hypothetical protein YP_689848.1 2490570 R 373384 CDS YP_689849.1 110806329 4209559 complement(2491842..2492084) 1 NC_008258.1 hypothetical protein 2492084 4209559 SFV_2435 Shigella flexneri 5 str. 8401 hypothetical protein YP_689849.1 2491842 R 373384 CDS YP_689850.1 110806330 4209560 2492437..2493357 1 NC_008258.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2493357 ddg 4209560 ddg Shigella flexneri 5 str. 8401 lipid A biosynthesis palmitoleoyl acyltransferase YP_689850.1 2492437 D 373384 CDS YP_689851.1 110806331 4208635 complement(2493848..2495002) 1 NC_008258.1 Code: E; COG: COG0436; aminotransferase 2495002 4208635 SFV_2437 Shigella flexneri 5 str. 8401 aminotransferase YP_689851.1 2493848 R 373384 CDS YP_689852.1 110806332 4208636 2495828..2496949 1 NC_008258.1 Code: T; COG: COG3275; sensor protein 2496949 4208636 SFV_2438 Shigella flexneri 5 str. 8401 sensor protein YP_689852.1 2495828 D 373384 CDS YP_689853.1 110806333 4208637 2496964..2497698 1 NC_008258.1 Code: KT; COG: COG3279; 2-component transcriptional regulator 2497698 4208637 SFV_2439 Shigella flexneri 5 str. 8401 2-component transcriptional regulator YP_689853.1 2496964 D 373384 CDS YP_689854.1 110806334 4208638 2497711..2498568 1 NC_008258.1 Code: K; COG: COG2207; AraC family transcriptional regulator 2498568 4208638 SFV_2440 Shigella flexneri 5 str. 8401 AraC family transcriptional regulator YP_689854.1 2497711 D 373384 CDS YP_689855.1 110806335 4208639 complement(2498571..2501066) 1 NC_008258.1 Code: G; COG: COG1080; PTS system enzyme IIA component, enzyme I 2501066 4208639 SFV_2441 Shigella flexneri 5 str. 8401 PTS system enzyme IIA component, enzyme I YP_689855.1 2498571 R 373384 CDS YP_689856.1 110806336 4208640 complement(2501091..2502128) 1 NC_008258.1 metalloprotein; exoaminopeptidase 2502128 4208640 SFV_2442 Shigella flexneri 5 str. 8401 exoaminopeptidase YP_689856.1 2501091 R 373384 CDS YP_689857.1 110806337 4208642 complement(2503226..2504473) 1 NC_008258.1 Code: G; COG: COG1299; transport protein 2504473 4208642 SFV_2444 Shigella flexneri 5 str. 8401 transport protein YP_689857.1 2503226 R 373384 CDS YP_689858.1 110806338 4208643 complement(2504495..2504821) 1 NC_008258.1 Code: G; COG: COG1445; PTS system enzyme IIB component 2504821 4208643 SFV_2445 Shigella flexneri 5 str. 8401 PTS system enzyme IIB component YP_689858.1 2504495 R 373384 CDS YP_689859.1 110806339 4208644 complement(2505040..2506005) 1 NC_008258.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2506005 glk 4208644 glk Shigella flexneri 5 str. 8401 glucokinase YP_689859.1 2505040 R 373384 CDS YP_689860.1 110806340 4208645 2506209..2507465 1 NC_008258.1 Code: P; COG: COG0038; hypothetical protein 2507465 4208645 SFV_2447 Shigella flexneri 5 str. 8401 hypothetical protein YP_689860.1 2506209 D 373384 CDS YP_689861.1 110806341 4208646 2507580..2507906 1 NC_008258.1 hypothetical protein 2507906 4208646 SFV_2448 Shigella flexneri 5 str. 8401 hypothetical protein YP_689861.1 2507580 D 373384 CDS YP_689862.1 110806342 4208647 complement(2508047..2509285) 1 NC_008258.1 Code: P; COG: COG1914; manganese transport protein MntH 2509285 4208647 SFV_2449 Shigella flexneri 5 str. 8401 manganese transport protein MntH YP_689862.1 2508047 R 373384 CDS YP_689863.1 110806343 4208648 2509621..2510823 1 NC_008258.1 Code: F; COG: COG1972; nucleoside transporter permease 2510823 nupC 4208648 nupC Shigella flexneri 5 str. 8401 nucleoside transporter permease YP_689863.1 2509621 D 373384 CDS YP_689864.1 110806344 4208649 complement(2510873..2513062) 1 NC_008258.1 hypothetical protein 2513062 yfeA 4208649 yfeA Shigella flexneri 5 str. 8401 hypothetical protein YP_689864.1 2510873 R 373384 CDS YP_689865.1 110806345 4208651 2513581..2513925 1 NC_008258.1 hypothetical protein 2513925 yfeC 4208651 yfeC Shigella flexneri 5 str. 8401 hypothetical protein YP_689865.1 2513581 D 373384 CDS YP_689866.1 110806346 4208652 2513927..2514325 1 NC_008258.1 hypothetical protein 2514325 yfeD 4208652 yfeD Shigella flexneri 5 str. 8401 hypothetical protein YP_689866.1 2513927 D 373384 CDS YP_689867.1 110806347 4208801 complement(2514377..2515792) 1 NC_008258.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2515792 gltX 4208801 gltX Shigella flexneri 5 str. 8401 glutamyl-tRNA synthetase YP_689867.1 2514377 R 373384 CDS YP_689868.1 110806348 4208805 2516601..2516942 1 NC_008258.1 hypothetical protein 2516942 flxA 4208805 flxA Shigella flexneri 5 str. 8401 hypothetical protein YP_689868.1 2516601 D 373384 CDS YP_689869.1 110806349 4208806 complement(2516933..2517859) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2517859 yfeR 4208806 yfeR Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_689869.1 2516933 R 373384 CDS YP_689870.1 110806350 4208807 2517949..2518947 1 NC_008258.1 Code: R; COG: COG0385; cytochrome oxidase 2518947 yfeH 4208807 yfeH Shigella flexneri 5 str. 8401 cytochrome oxidase YP_689870.1 2517949 D 373384 CDS YP_689871.1 110806351 4208808 complement(2518944..2519162) 1 NC_008258.1 Code: S; COG: COG3530; cytoplasmic protein 2519162 ypeB 4208808 ypeB Shigella flexneri 5 str. 8401 cytoplasmic protein YP_689871.1 2518944 R 373384 CDS YP_689872.1 110806352 4208809 complement(2519164..2521179) 1 NC_008258.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2521179 ligA 4208809 ligA Shigella flexneri 5 str. 8401 NAD-dependent DNA ligase LigA YP_689872.1 2519164 R 373384 CDS YP_689873.1 110806353 4208810 complement(2521250..2522275) 1 NC_008258.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2522275 zipA 4208810 zipA Shigella flexneri 5 str. 8401 cell division protein ZipA YP_689873.1 2521250 R 373384 CDS YP_689874.1 110806354 4208811 2522466..2523227 1 NC_008258.1 role in sulfur assimilation; sulfate transport protein CysZ 2523227 cysZ 4208811 cysZ Shigella flexneri 5 str. 8401 sulfate transport protein CysZ YP_689874.1 2522466 D 373384 CDS YP_689875.1 110806355 4208812 2523412..2524383 1 NC_008258.1 O-acetylserine sulfhydrolase A; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2524383 cysK 4208812 cysK Shigella flexneri 5 str. 8401 cysteine synthase A YP_689875.1 2523412 D 373384 CDS YP_689876.1 110806356 4208813 2524767..2525024 1 NC_008258.1 Code: G; COG: COG1925; PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr 2525024 ptsH 4208813 ptsH Shigella flexneri 5 str. 8401 PTS system phosphohistidinoprotein-hexose phosphotransferase subunit Hpr YP_689876.1 2524767 D 373384 CDS YP_689877.1 110806357 4208814 2525069..2526796 1 NC_008258.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2526796 ptsI 4208814 ptsI Shigella flexneri 5 str. 8401 phosphoenolpyruvate-protein phosphotransferase YP_689877.1 2525069 D 373384 CDS YP_689878.1 110806358 4208815 2526837..2527346 1 NC_008258.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter subunit 2527346 crr 4208815 crr Shigella flexneri 5 str. 8401 PTS system glucose-specific transporter subunit YP_689878.1 2526837 D 373384 CDS YP_689879.1 110806359 4208816 complement(2527388..2528239) 1 NC_008258.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2528239 pdxK 4208816 pdxK Shigella flexneri 5 str. 8401 pyridoxal kinase YP_689879.1 2527388 R 373384 CDS YP_689880.1 110806360 4208672 2528344..2528718 1 NC_008258.1 hypothetical protein 2528718 yfeK 4208672 yfeK Shigella flexneri 5 str. 8401 hypothetical protein YP_689880.1 2528344 D 373384 CDS YP_689881.1 110806361 4208673 2528751..2529158 1 NC_008258.1 hypothetical protein 2529158 4208673 SFV_2472 Shigella flexneri 5 str. 8401 hypothetical protein YP_689881.1 2528751 D 373384 CDS YP_689882.1 110806362 4208674 2529127..2529474 1 NC_008258.1 Code: S; COG: COG4884; hypothetical protein 2529474 4208674 SFV_2473 Shigella flexneri 5 str. 8401 hypothetical protein YP_689882.1 2529127 D 373384 CDS YP_689883.1 110806363 4208675 complement(2529678..2530667) 1 NC_008258.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2530667 cysM 4208675 cysM Shigella flexneri 5 str. 8401 cysteine synthase B YP_689883.1 2529678 R 373384 CDS YP_689884.1 110806364 4208676 complement(2530723..2531820) 1 NC_008258.1 Code: P; COG: COG1118; sulfate/thiosulfate transporter subunit 2531820 cysA 4208676 cysA Shigella flexneri 5 str. 8401 sulfate/thiosulfate transporter subunit YP_689884.1 2530723 R 373384 CDS YP_689885.1 110806365 4208677 complement(2531810..2532685) 1 NC_008258.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2532685 cysW 4208677 cysW Shigella flexneri 5 str. 8401 sulfate/thiosulfate transporter permease subunit YP_689885.1 2531810 R 373384 CDS YP_689886.1 110806366 4208678 complement(2532685..2533518) 1 NC_008258.1 Code: O; COG: COG0555; sulfate/thiosulfate transporter subunit 2533518 cysU 4208678 cysU Shigella flexneri 5 str. 8401 sulfate/thiosulfate transporter subunit YP_689886.1 2532685 R 373384 CDS YP_689887.1 110806367 4208679 complement(2533518..2534534) 1 NC_008258.1 Code: P; COG: COG4150; thiosulfate transporter subunit 2534534 cysP 4208679 cysP Shigella flexneri 5 str. 8401 thiosulfate transporter subunit YP_689887.1 2533518 R 373384 CDS YP_689888.1 110806368 4208680 complement(2534838..2535629) 1 NC_008258.1 Code: IQR; COG: COG1028; short chain dehydrogenase 2535629 ucpA 4208680 ucpA Shigella flexneri 5 str. 8401 short chain dehydrogenase YP_689888.1 2534838 R 373384 CDS YP_689889.1 110806369 4208681 complement(2535816..2536616) 1 NC_008258.1 Code: K; COG: COG1737; hypothetical protein 2536616 yfeT 4208681 yfeT Shigella flexneri 5 str. 8401 hypothetical protein YP_689889.1 2535816 R 373384 CDS YP_689890.1 110806370 4208682 2536780..2537676 1 NC_008258.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 2537676 murQ 4208682 murQ Shigella flexneri 5 str. 8401 N-acetylmuramic acid-6-phosphate etherase YP_689890.1 2536780 D 373384 CDS YP_689891.1 110806371 4208683 2537680..2539104 1 NC_008258.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunits EIIBC 2539104 murP 4208683 murP Shigella flexneri 5 str. 8401 PTS system N-acetylmuramic acid transporter subunits EIIBC YP_689891.1 2537680 D 373384 CDS YP_689892.1 110806372 4208684 complement(2539284..2540183) 1 NC_008258.1 Code: P; COG: COG2837; hypothetical protein 2540183 4208684 SFV_2483 Shigella flexneri 5 str. 8401 hypothetical protein YP_689892.1 2539284 R 373384 CDS YP_689893.1 110806373 4208685 complement(2540279..2540854) 1 NC_008258.1 hypothetical protein 2540854 4208685 SFV_2484 Shigella flexneri 5 str. 8401 hypothetical protein YP_689893.1 2540279 R 373384 CDS YP_689894.1 110806374 4208686 complement(2540915..2541370) 1 NC_008258.1 hypothetical protein 2541370 4208686 SFV_2485 Shigella flexneri 5 str. 8401 hypothetical protein YP_689894.1 2540915 R 373384 CDS YP_689895.1 110806375 4208687 complement(2541351..2541887) 1 NC_008258.1 Code: R; COG: COG0456; acetyltransferase 2541887 4208687 SFV_2486 Shigella flexneri 5 str. 8401 acetyltransferase YP_689895.1 2541351 R 373384 CDS YP_689896.1 110806376 4208688 2541990..2542859 1 NC_008258.1 Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase 2542859 amiA 4208688 amiA Shigella flexneri 5 str. 8401 N-acetylmuramoyl-L-alanine amidase YP_689896.1 2541990 D 373384 CDS YP_689897.1 110806377 4208689 2542863..2543762 1 NC_008258.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2543762 hemF 4208689 hemF Shigella flexneri 5 str. 8401 coproporphyrinogen III oxidase YP_689897.1 2542863 D 373384 CDS YP_689898.1 110806378 4208690 complement(2543768..2544820) 1 NC_008258.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2544820 yfeG 4208690 yfeG Shigella flexneri 5 str. 8401 transcriptional regulator EutR YP_689898.1 2543768 R 373384 CDS YP_689899.1 110806379 4208691 complement(2544866..2545366) 1 NC_008258.1 Code: QC; COG: COG4577; hypothetical protein 2545366 4208691 SFV_2490 Shigella flexneri 5 str. 8401 hypothetical protein YP_689899.1 2544866 R 373384 CDS YP_689900.1 110806380 4209616 complement(2545379..2546038) 1 NC_008258.1 Code: E; COG: COG4816; hypothetical protein 2546038 4209616 SFV_2491 Shigella flexneri 5 str. 8401 hypothetical protein YP_689900.1 2545379 R 373384 CDS YP_689901.1 110806381 4209617 2547220..2547963 1 NC_008258.1 hypothetical protein 2547963 4209617 SFV_2492 Shigella flexneri 5 str. 8401 hypothetical protein YP_689901.1 2547220 D 373384 CDS YP_689902.1 110806382 4209618 2548191..2548673 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2548673 insB 4209618 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_689902.1 2548191 D 373384 CDS YP_689903.1 110806383 4209619 2549507..2549761 1 NC_008258.1 hypothetical protein 2549761 4209619 SFV_2494 Shigella flexneri 5 str. 8401 hypothetical protein YP_689903.1 2549507 D 373384 CDS YP_689904.1 110806384 4209620 2549919..2550182 1 NC_008258.1 hypothetical protein 2550182 4209620 SFV_2495 Shigella flexneri 5 str. 8401 hypothetical protein YP_689904.1 2549919 D 373384 CDS YP_689905.1 110806385 4209621 2550205..2550747 1 NC_008258.1 hypothetical protein 2550747 4209621 SFV_2496 Shigella flexneri 5 str. 8401 hypothetical protein YP_689905.1 2550205 D 373384 CDS YP_689906.1 110806386 4209622 2551212..2551418 1 NC_008258.1 hypothetical protein 2551418 4209622 SFV_2497 Shigella flexneri 5 str. 8401 hypothetical protein YP_689906.1 2551212 D 373384 CDS YP_689907.1 110806387 4209623 2551730..2552215 1 NC_008258.1 hypothetical protein 2552215 4209623 SFV_2498 Shigella flexneri 5 str. 8401 hypothetical protein YP_689907.1 2551730 D 373384 CDS YP_689908.1 110806388 4209624 2552467..2553927 1 NC_008258.1 Code: E; COG: COG0531; amino acid antiporter 2553927 4209624 SFV_2499 Shigella flexneri 5 str. 8401 amino acid antiporter YP_689908.1 2552467 D 373384 CDS YP_689909.1 110806389 4209625 2554078..2554770 1 NC_008258.1 Code: M; COG: COG0796; hypothetical protein 2554770 4209625 SFV_2500 Shigella flexneri 5 str. 8401 hypothetical protein YP_689909.1 2554078 D 373384 CDS YP_689910.1 110806390 4209626 complement(2554889..2555284) 1 NC_008258.1 Code: L; COG: COG1662; iso-IS1 ORF2 2555284 4209626 SFV_2501 Shigella flexneri 5 str. 8401 iso-IS1 ORF2 YP_689910.1 2554889 R 373384 CDS YP_689911.2 162139331 4209627 complement(2555618..2556523) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 2556523 4209627 SFV_2502 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_689911.2 2555618 R 373384 CDS YP_689912.1 110806392 4209628 complement(2556481..2556846) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2556846 4209628 SFV_2503 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_689912.1 2556481 R 373384 CDS YP_689913.1 110806393 4209629 complement(2557439..2558812) 1 NC_008258.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2558812 eutA 4209629 eutA Shigella flexneri 5 str. 8401 reactivating factor for ethanolamine ammonia lyase YP_689913.1 2557439 R 373384 CDS YP_689914.1 110806394 4209630 complement(2558787..2559266) 1 NC_008258.1 Code: E; COG: COG4917; hypothetical protein 2559266 4209630 SFV_2505 Shigella flexneri 5 str. 8401 hypothetical protein YP_689914.1 2558787 R 373384 CDS YP_689915.1 110806395 4209631 complement(2559279..2559686) 1 NC_008258.1 Code: E; COG: COG4810; hypothetical protein 2559686 4209631 SFV_2506 Shigella flexneri 5 str. 8401 hypothetical protein YP_689915.1 2559279 R 373384 CDS YP_689916.1 110806396 4209632 complement(2559907..2562186) 1 NC_008258.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2562186 4209632 SFV_2507 Shigella flexneri 5 str. 8401 malic enzyme YP_689916.1 2559907 R 373384 CDS YP_689917.1 110806397 4209633 2562475..2563425 1 NC_008258.1 Code: G; COG: COG0176; transaldolase A 2563425 talA 4209633 talA Shigella flexneri 5 str. 8401 transaldolase A YP_689917.1 2562475 D 373384 CDS YP_689918.1 110806398 4209634 2563445..2565448 1 NC_008258.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2565448 tktB 4209634 tktB Shigella flexneri 5 str. 8401 transketolase YP_689918.1 2563445 D 373384 CDS YP_689919.1 110806399 4208536 complement(2565551..2566594) 1 NC_008258.1 hypothetical protein 2566594 4208536 SFV_2510 Shigella flexneri 5 str. 8401 hypothetical protein YP_689919.1 2565551 R 373384 CDS YP_689920.1 110806400 4208537 complement(2566720..2567295) 1 NC_008258.1 Code: LR; COG: COG0494; hypothetical protein 2567295 yffH 4208537 yffH Shigella flexneri 5 str. 8401 hypothetical protein YP_689920.1 2566720 R 373384 CDS YP_689921.1 110806401 4208538 complement(2567363..2569342) 1 NC_008258.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 2569342 yffG 4208538 yffG Shigella flexneri 5 str. 8401 oxidoreductase Fe-S binding subunit YP_689921.1 2567363 R 373384 CDS YP_689922.1 110806402 4208540 2571467..2574580 1 NC_008258.1 Code: V; COG: COG0841; aminoglycoside/multidrug efflux system 2574580 acrD 4208540 acrD Shigella flexneri 5 str. 8401 aminoglycoside/multidrug efflux system YP_689922.1 2571467 D 373384 CDS YP_689923.1 110806403 4208541 2575119..2575475 1 NC_008258.1 Code: P; COG: COG1393; hypothetical protein 2575475 yffB 4208541 yffB Shigella flexneri 5 str. 8401 hypothetical protein YP_689923.1 2575119 D 373384 CDS YP_689924.1 110806404 4208542 2575479..2576606 1 NC_008258.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2576606 dapE 4208542 dapE Shigella flexneri 5 str. 8401 succinyl-diaminopimelate desuccinylase YP_689924.1 2575479 D 373384 CDS YP_689925.2 229774939 4208543 2576634..2576834 1 NC_008258.1 hypothetical protein 2576834 4208543 SFV_2517 Shigella flexneri 5 str. 8401 hypothetical protein YP_689925.2 2576634 D 373384 CDS YP_689926.1 110806406 4208544 complement(2576944..2577642) 1 NC_008258.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 2577642 ypfH 4208544 ypfH Shigella flexneri 5 str. 8401 esterase YP_689926.1 2576944 R 373384 CDS YP_689927.1 110806407 4208545 complement(2577716..2579731) 1 NC_008258.1 Code: R; COG: COG1444; hypothetical protein 2579731 ypfI 4208545 ypfI Shigella flexneri 5 str. 8401 hypothetical protein YP_689927.1 2577716 R 373384 CDS YP_689928.1 110806408 4208546 complement(2579746..2580609) 1 NC_008258.1 Code: R; COG: COG2321; hypothetical protein 2580609 4208546 SFV_2520 Shigella flexneri 5 str. 8401 hypothetical protein YP_689928.1 2579746 R 373384 CDS YP_689929.1 110806409 4208547 complement(2580777..2581490) 1 NC_008258.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2581490 purC 4208547 purC Shigella flexneri 5 str. 8401 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_689929.1 2580777 R 373384 CDS YP_689930.1 110806410 4208548 complement(2581703..2582737) 1 NC_008258.1 Code: M; COG: COG3317; lipoprotein 2582737 nlpB 4208548 nlpB Shigella flexneri 5 str. 8401 lipoprotein YP_689930.1 2581703 R 373384 CDS YP_689931.1 110806411 4208549 complement(2582754..2583632) 1 NC_008258.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2583632 dapA 4208549 dapA Shigella flexneri 5 str. 8401 dihydrodipicolinate synthase YP_689931.1 2582754 R 373384 CDS YP_689932.1 110806412 4208550 2583778..2584350 1 NC_008258.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2584350 gcvR 4208550 gcvR Shigella flexneri 5 str. 8401 glycine cleavage system transcriptional repressor YP_689932.1 2583778 D 373384 CDS YP_689933.1 110806413 4208551 2584350..2584820 1 NC_008258.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2584820 bcp 4208551 bcp Shigella flexneri 5 str. 8401 thioredoxin-dependent thiol peroxidase YP_689933.1 2584350 D 373384 CDS YP_689934.1 110806414 4208552 2585073..2585690 1 NC_008258.1 Code: C; COG: COG1142; hydrogenase 4 Fe-S subunit 2585690 hyfA 4208552 hyfA Shigella flexneri 5 str. 8401 hydrogenase 4 Fe-S subunit YP_689934.1 2585073 D 373384 CDS YP_689935.1 110806415 4208554 2587718..2588665 1 NC_008258.1 Code: C; COG: COG0650; hydrogenase 4 membrane subunit 2588665 hyfC 4208554 hyfC Shigella flexneri 5 str. 8401 hydrogenase 4 membrane subunit YP_689935.1 2587718 D 373384 CDS YP_689936.1 110806416 4208555 2588709..2590121 1 NC_008258.1 Code: CP; COG: COG1009; hydrogenase 4 subunit D 2590121 hyfD 4208555 hyfD Shigella flexneri 5 str. 8401 hydrogenase 4 subunit D YP_689936.1 2588709 D 373384 CDS YP_689937.1 110806417 4208459 2590133..2590783 1 NC_008258.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2590783 hyfE 4208459 hyfE Shigella flexneri 5 str. 8401 hydrogenase 4 membrane subunit YP_689937.1 2590133 D 373384 CDS YP_689938.1 110806418 4208460 2590788..2592380 1 NC_008258.1 Code: CP; COG: COG0651; hydrogenase 4 subunit F 2592380 hyfF 4208460 hyfF Shigella flexneri 5 str. 8401 hydrogenase 4 subunit F YP_689938.1 2590788 D 373384 CDS YP_689939.1 110806419 4208462 2594094..2594639 1 NC_008258.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2594639 hyfH 4208462 hyfH Shigella flexneri 5 str. 8401 hydrogenase 4 subunit H YP_689939.1 2594094 D 373384 CDS YP_689940.1 110806420 4208463 2594636..2595394 1 NC_008258.1 Code: C; COG: COG3260; hydrogenase 4 Fe-S subunit 2595394 hyfI 4208463 hyfI Shigella flexneri 5 str. 8401 hydrogenase 4 Fe-S subunit YP_689940.1 2594636 D 373384 CDS YP_689941.1 110806421 4208464 2595324..2595800 1 NC_008258.1 protein processing element 2595800 4208464 SFV_2535 Shigella flexneri 5 str. 8401 protein processing element YP_689941.1 2595324 D 373384 CDS YP_689942.1 110806422 4208465 2595896..2597842 1 NC_008258.1 Code: KT; COG: COG3604; 2-component regulator, interaction with sigma 54 2597842 hyfR 4208465 hyfR Shigella flexneri 5 str. 8401 2-component regulator, interaction with sigma 54 YP_689942.1 2595896 D 373384 CDS YP_689943.1 110806423 4208467 complement(2598750..2599811) 1 NC_008258.1 Code: R; COG: COG0628; permease 2599811 perM 4208467 perM Shigella flexneri 5 str. 8401 permease YP_689943.1 2598750 R 373384 CDS YP_689944.1 110806424 4208468 2600024..2601487 1 NC_008258.1 Code: R; COG: COG4783; hypothetical protein 2601487 4208468 SFV_2539 Shigella flexneri 5 str. 8401 hypothetical protein YP_689944.1 2600024 D 373384 CDS YP_689945.1 110806425 4208469 2601508..2601867 1 NC_008258.1 Code: P; COG: COG1393; oxidoreductase 2601867 4208469 SFV_2540 Shigella flexneri 5 str. 8401 oxidoreductase YP_689945.1 2601508 D 373384 CDS YP_689946.1 110806426 4208470 complement(2602000..2602746) 1 NC_008258.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2602746 4208470 SFV_2541 Shigella flexneri 5 str. 8401 DNA replication initiation factor YP_689946.1 2602000 R 373384 CDS YP_689947.1 110806427 4208471 complement(2602796..2604022) 1 NC_008258.1 Code: F; COG: COG2233; uracil transporter 2604022 uraA 4208471 uraA Shigella flexneri 5 str. 8401 uracil transporter YP_689947.1 2602796 R 373384 CDS YP_689948.1 110806428 4208472 complement(2604171..2604797) 1 NC_008258.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2604797 upp 4208472 upp Shigella flexneri 5 str. 8401 uracil phosphoribosyltransferase YP_689948.1 2604171 R 373384 CDS YP_689949.1 110806429 4208473 2605121..2606158 1 NC_008258.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2606158 purM 4208473 purM Shigella flexneri 5 str. 8401 phosphoribosylaminoimidazole synthetase YP_689949.1 2605121 D 373384 CDS YP_689950.1 110806430 4208474 2606158..2606796 1 NC_008258.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2606796 purN 4208474 purN Shigella flexneri 5 str. 8401 phosphoribosylglycinamide formyltransferase YP_689950.1 2606158 D 373384 CDS YP_689951.1 110806431 4208475 2606968..2609034 1 NC_008258.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2609034 ppk 4208475 ppk Shigella flexneri 5 str. 8401 polyphosphate kinase YP_689951.1 2606968 D 373384 CDS YP_689952.1 110806432 4208476 2609111..2610580 1 NC_008258.1 Code: FP; COG: COG0248; exopolyphosphatase 2610580 ppx 4208476 ppx Shigella flexneri 5 str. 8401 exopolyphosphatase YP_689952.1 2609111 D 373384 CDS YP_689953.1 110806433 4208477 2611794..2612096 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 2612096 4208477 SFV_2548 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_689953.1 2611794 D 373384 CDS YP_689954.1 110806434 4207508 2612237..2612950 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2612950 4207508 SFV_2549 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_689954.1 2612237 D 373384 CDS YP_689955.1 110806435 4207510 2614480..2614671 1 NC_008258.1 hypothetical protein 2614671 4207510 SFV_2551 Shigella flexneri 5 str. 8401 hypothetical protein YP_689955.1 2614480 D 373384 CDS YP_689956.1 110806436 4207511 2614988..2615503 1 NC_008258.1 outer membrane lipoprotein 2615503 4207511 SFV_2552 Shigella flexneri 5 str. 8401 outer membrane lipoprotein YP_689956.1 2614988 D 373384 CDS YP_689957.1 110806437 4207512 2615519..2616058 1 NC_008258.1 hypothetical protein 2616058 4207512 SFV_2553 Shigella flexneri 5 str. 8401 hypothetical protein YP_689957.1 2615519 D 373384 CDS YP_689958.1 110806438 4207513 complement(2616153..2617730) 1 NC_008258.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2617730 guaA 4207513 guaA Shigella flexneri 5 str. 8401 GMP synthase YP_689958.1 2616153 R 373384 CDS YP_689959.1 110806439 4207514 complement(2617799..2619271) 1 NC_008258.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2619271 guaB 4207514 guaB Shigella flexneri 5 str. 8401 inosine 5'-monophosphate dehydrogenase YP_689959.1 2617799 R 373384 CDS YP_689960.1 110806440 4207515 2619427..2620797 1 NC_008258.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2620797 xseA 4207515 xseA Shigella flexneri 5 str. 8401 exodeoxyribonuclease VII large subunit YP_689960.1 2619427 D 373384 CDS YP_689961.1 110806441 4207516 complement(2620794..2621045) 1 NC_008258.1 hypothetical protein 2621045 4207516 SFV_2557 Shigella flexneri 5 str. 8401 hypothetical protein YP_689961.1 2620794 R 373384 CDS YP_689962.1 110806442 4207517 complement(2621079..2622551) 1 NC_008258.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2622551 engA 4207517 engA Shigella flexneri 5 str. 8401 GTP-binding protein EngA YP_689962.1 2621079 R 373384 CDS YP_689963.1 110806443 4207518 complement(2622669..2623847) 1 NC_008258.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2623847 4207518 SFV_2559 Shigella flexneri 5 str. 8401 outer membrane protein assembly complex subunit YfgL YP_689963.1 2622669 R 373384 CDS YP_689964.1 110806444 4207519 complement(2623858..2624478) 1 NC_008258.1 Code: S; COG: COG2976; hypothetical protein 2624478 4207519 SFV_2560 Shigella flexneri 5 str. 8401 hypothetical protein YP_689964.1 2623858 R 373384 CDS YP_689965.1 110806445 4207520 complement(2624496..2625740) 1 NC_008258.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2625740 hisS 4207520 hisS Shigella flexneri 5 str. 8401 histidyl-tRNA synthetase YP_689965.1 2624496 R 373384 CDS YP_689966.1 110806446 4207521 complement(2625873..2627000) 1 NC_008258.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2627000 ispG 4207521 ispG Shigella flexneri 5 str. 8401 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_689966.1 2625873 R 373384 CDS YP_689967.1 110806447 4207522 complement(2627027..2628040) 1 NC_008258.1 Code: S; COG: COG1426; cytoskeletal protein RodZ 2628040 yfgA 4207522 yfgA Shigella flexneri 5 str. 8401 cytoskeletal protein RodZ YP_689967.1 2627027 R 373384 CDS YP_689968.1 110806448 4207523 complement(2628325..2629479) 1 NC_008258.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2629479 yfgB 4207523 yfgB Shigella flexneri 5 str. 8401 ribosomal RNA large subunit methyltransferase N YP_689968.1 2628325 R 373384 CDS YP_689969.1 110806449 4207524 complement(2629629..2630060) 1 NC_008258.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2630060 ndk 4207524 ndk Shigella flexneri 5 str. 8401 nucleoside diphosphate kinase YP_689969.1 2629629 R 373384 CDS YP_689970.1 110806450 4207525 complement(2630210..2632258) 1 NC_008258.1 Code: M; COG: COG4953; peptidoglycan protein 2632258 pbpC 4207525 pbpC Shigella flexneri 5 str. 8401 peptidoglycan protein YP_689970.1 2630210 R 373384 CDS YP_689971.1 110806451 4207526 complement(2632260..2632676) 1 NC_008258.1 ISSfl2 ORF 2632676 4207526 SFV_2567 Shigella flexneri 5 str. 8401 ISSfl2 ORF YP_689971.1 2632260 R 373384 CDS YP_689972.1 110806452 4207527 complement(2632855..2633457) 1 NC_008258.1 ISSfl2 ORF 2633457 4207527 SFV_2568 Shigella flexneri 5 str. 8401 ISSfl2 ORF YP_689972.1 2632855 R 373384 CDS YP_689973.1 110806453 4207305 complement(2634988..2635773) 1 NC_008258.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2635773 sseB 4207305 sseB Shigella flexneri 5 str. 8401 enhanced serine sensitivity protein SseB YP_689973.1 2634988 R 373384 CDS YP_689974.1 110806454 4207306 complement(2635906..2637189) 1 NC_008258.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase 2637189 pepB 4207306 pepB Shigella flexneri 5 str. 8401 aminopeptidase YP_689974.1 2635906 R 373384 CDS YP_689975.1 110806455 4207307 complement(2637248..2637448) 1 NC_008258.1 Code: S; COG: COG2975; hypothetical protein 2637448 yfhJ 4207307 yfhJ Shigella flexneri 5 str. 8401 hypothetical protein YP_689975.1 2637248 R 373384 CDS YP_689976.1 110806456 4207308 complement(2637460..2637795) 1 NC_008258.1 Code: C; COG: COG0633; [2FE-2S] ferredoxin, electron carrer protein 2637795 fdx 4207308 fdx Shigella flexneri 5 str. 8401 [2FE-2S] ferredoxin, electron carrer protein YP_689976.1 2637460 R 373384 CDS YP_689977.1 110806457 4207309 complement(2637797..2639647) 1 NC_008258.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2639647 hscA 4207309 hscA Shigella flexneri 5 str. 8401 chaperone protein HscA YP_689977.1 2637797 R 373384 CDS YP_689978.1 110806458 4207310 complement(2639664..2640179) 1 NC_008258.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2640179 hscB 4207310 hscB Shigella flexneri 5 str. 8401 co-chaperone HscB YP_689978.1 2639664 R 373384 CDS YP_689979.1 110806459 4207311 complement(2640275..2640604) 1 NC_008258.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2640604 iscA 4207311 iscA Shigella flexneri 5 str. 8401 iron-sulfur cluster assembly protein YP_689979.1 2640275 R 373384 CDS YP_689980.1 110806460 4207312 complement(2640615..2641001) 1 NC_008258.1 Code: C; COG: COG0822; scaffold protein 2641001 4207312 SFV_2577 Shigella flexneri 5 str. 8401 scaffold protein YP_689980.1 2640615 R 373384 CDS YP_689981.1 110806461 4207313 complement(2641029..2642243) 1 NC_008258.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2642243 yfhO 4207313 yfhO Shigella flexneri 5 str. 8401 cysteine desulfurase YP_689981.1 2641029 R 373384 CDS YP_689982.1 110806462 4207314 complement(2642355..2642843) 1 NC_008258.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2642843 4207314 SFV_2579 Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator IscR YP_689982.1 2642355 R 373384 CDS YP_689983.1 110806463 4207315 complement(2643113..2643853) 1 NC_008258.1 Code: J; COG: COG0565; ATP synthase subunit beta 2643853 4207315 SFV_2580 Shigella flexneri 5 str. 8401 ATP synthase subunit beta YP_689983.1 2643113 R 373384 CDS YP_689984.1 110806464 4207316 2643972..2644775 1 NC_008258.1 Code: G; COG: COG0483; inositol monophosphatase 2644775 suhB 4207316 suhB Shigella flexneri 5 str. 8401 inositol monophosphatase YP_689984.1 2643972 D 373384 CDS YP_689985.1 110806465 4207317 2644920..2645774 1 NC_008258.1 Code: R; COG: COG1073; hypothetical protein 2645774 4207317 SFV_2582 Shigella flexneri 5 str. 8401 hypothetical protein YP_689985.1 2644920 D 373384 CDS YP_689986.1 110806466 4207318 2645965..2647245 1 NC_008258.1 Code: K; COG: COG3711; stationary phase inducible protein CsiE 2647245 csiE 4207318 csiE Shigella flexneri 5 str. 8401 stationary phase inducible protein CsiE YP_689986.1 2645965 D 373384 CDS YP_689987.1 110806467 4207319 complement(2647237..2648376) 1 NC_008258.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 2648376 hcaT 4207319 hcaT Shigella flexneri 5 str. 8401 3-phenylpropionic acid transporter YP_689987.1 2647237 R 373384 CDS YP_689988.1 110806468 4207320 complement(2648536..2649426) 1 NC_008258.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 2649426 hcaR 4207320 hcaR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator HcaR YP_689988.1 2648536 R 373384 CDS YP_689989.1 110806469 4207321 2649562..2650923 1 NC_008258.1 Code: PR; COG: COG4638; large terminal subunit of phenylpropionate dioxygenase 2650923 hcaA1 4207321 hcaA1 Shigella flexneri 5 str. 8401 large terminal subunit of phenylpropionate dioxygenase YP_689989.1 2649562 D 373384 CDS YP_689990.1 110806470 4207322 2650920..2651438 1 NC_008258.1 Code: Q; COG: COG5517; 3-phenylpropionate dioxygenase subunit beta 2651438 hcaA2 4207322 hcaA2 Shigella flexneri 5 str. 8401 3-phenylpropionate dioxygenase subunit beta YP_689990.1 2650920 D 373384 CDS YP_689991.1 110806471 4210036 2651438..2651758 1 NC_008258.1 Code: PR; COG: COG2146; 3-phenylpropionate dioxygenase ferredoxin subunit 2651758 hcaC 4210036 hcaC Shigella flexneri 5 str. 8401 3-phenylpropionate dioxygenase ferredoxin subunit YP_689991.1 2651438 D 373384 CDS YP_689992.1 110806472 4210037 2651755..2652567 1 NC_008258.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2652567 hcaB 4210037 hcaB Shigella flexneri 5 str. 8401 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_689992.1 2651755 D 373384 CDS YP_689993.1 110806473 4210038 2652577..2653809 1 NC_008258.1 Code: R; COG: COG0446; phenylpropionate dioxygenase ferredoxin reductase subunit 2653809 hcaD 4210038 hcaD Shigella flexneri 5 str. 8401 phenylpropionate dioxygenase ferredoxin reductase subunit YP_689993.1 2652577 D 373384 CDS YP_689994.1 110806474 4210039 2653834..2654238 1 NC_008258.1 Code: S; COG: COG2259; hypothetical protein 2654238 yphA 4210039 yphA Shigella flexneri 5 str. 8401 hypothetical protein YP_689994.1 2653834 D 373384 CDS YP_689995.1 110806475 4210040 complement(2654375..2655247) 1 NC_008258.1 Code: G; COG: COG2017; hypothetical protein 2655247 yphB 4210040 yphB Shigella flexneri 5 str. 8401 hypothetical protein YP_689995.1 2654375 R 373384 CDS YP_689996.1 110806476 4210041 complement(2655259..2656320) 1 NC_008258.1 Code: ER; COG: COG1063; oxidoreductase 2656320 yphC 4210041 yphC Shigella flexneri 5 str. 8401 oxidoreductase YP_689996.1 2655259 R 373384 CDS YP_689997.1 110806477 4210042 complement(2656386..2657384) 1 NC_008258.1 Code: G; COG: COG1172; transport system permease 2657384 yphD 4210042 yphD Shigella flexneri 5 str. 8401 transport system permease YP_689997.1 2656386 R 373384 CDS YP_689998.1 110806478 4210043 complement(2657409..2658920) 1 NC_008258.1 Code: G; COG: COG1129; ABC transporter ATP-binding protein 2658920 yphE 4210043 yphE Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_689998.1 2657409 R 373384 CDS YP_689999.1 110806479 4210044 complement(2658943..2659926) 1 NC_008258.1 Code: G; COG: COG1879; LACI-type transcriptional regulator 2659926 yphF 4210044 yphF Shigella flexneri 5 str. 8401 LACI-type transcriptional regulator YP_689999.1 2658943 R 373384 CDS YP_690000.1 110806480 4210046 2663416..2664615 1 NC_008258.1 Code: KG; COG: COG1940; NAGC-like transcriptional regulator 2664615 yphH 4210046 yphH Shigella flexneri 5 str. 8401 NAGC-like transcriptional regulator YP_690000.1 2663416 D 373384 CDS YP_690001.1 110806481 4210047 complement(2664813..2666066) 1 NC_008258.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2666066 glyA 4210047 glyA Shigella flexneri 5 str. 8401 serine hydroxymethyltransferase YP_690001.1 2664813 R 373384 CDS YP_690002.1 110806482 4210048 2666393..2667583 1 NC_008258.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2667583 hmpA 4210048 hmpA Shigella flexneri 5 str. 8401 nitric oxide dioxygenase YP_690002.1 2666393 D 373384 CDS YP_690003.1 110806483 4210049 complement(2667628..2667966) 1 NC_008258.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2667966 glnB 4210049 glnB Shigella flexneri 5 str. 8401 nitrogen regulatory protein P-II 1 YP_690003.1 2667628 R 373384 CDS YP_690004.1 110806484 4210050 complement(2668027..2669361) 1 NC_008258.1 Code: T; COG: COG2204; 2-component transcriptional regulator 2669361 yfhA 4210050 yfhA Shigella flexneri 5 str. 8401 2-component transcriptional regulator YP_690004.1 2668027 R 373384 CDS YP_690005.1 110806485 4210051 complement(2669351..2670070) 1 NC_008258.1 hypothetical protein 2670070 yfhG 4210051 yfhG Shigella flexneri 5 str. 8401 hypothetical protein YP_690005.1 2669351 R 373384 CDS YP_690006.1 110806486 4210052 complement(2670229..2671656) 1 NC_008258.1 Code: T; COG: COG0642; 2-component sensor protein 2671656 yfhK 4210052 yfhK Shigella flexneri 5 str. 8401 2-component sensor protein YP_690006.1 2670229 R 373384 CDS YP_690007.1 110806487 4210053 complement(2672232..2676275) 1 NC_008258.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2676275 purL 4210053 purL Shigella flexneri 5 str. 8401 phosphoribosylformylglycinamidine synthase YP_690007.1 2672232 R 373384 CDS YP_690008.1 110806488 4210054 2676516..2677934 1 NC_008258.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2677934 yfhD 4210054 yfhD Shigella flexneri 5 str. 8401 transglycosylase YP_690008.1 2676516 D 373384 CDS YP_690009.1 110806489 4210055 complement(2677931..2678434) 1 NC_008258.1 Code: FJ; COG: COG0590; tRNA-specific adenosine deaminase 2678434 yfhC 4210055 yfhC Shigella flexneri 5 str. 8401 tRNA-specific adenosine deaminase YP_690009.1 2677931 R 373384 CDS YP_690010.1 110806490 4207701 complement(2678492..2679103) 1 NC_008258.1 Code: E; COG: COG0560; hypothetical protein 2679103 yfhB 4207701 yfhB Shigella flexneri 5 str. 8401 hypothetical protein YP_690010.1 2678492 R 373384 CDS YP_690011.1 110806491 4207702 2679264..2680184 1 NC_008258.1 Code: K; COG: COG1737; DNA-binding transcriptional regulator 2680184 yfhH 4207702 yfhH Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_690011.1 2679264 D 373384 CDS YP_690012.1 110806492 4207703 complement(2680637..2681077) 1 NC_008258.1 Code: L; COG: COG1961; DNA-invertase 2681077 pin 4207703 pin Shigella flexneri 5 str. 8401 DNA-invertase YP_690012.1 2680637 R 373384 CDS YP_690013.1 110806493 4207704 2681569..2683395 1 NC_008258.1 Code: S; COG: COG4886; invasion plasmid antigen 2683395 ipaH_6 4207704 ipaH_6 Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_690013.1 2681569 D 373384 CDS YP_690014.1 110806494 4207705 complement(2683575..2684198) 1 NC_008258.1 hypothetical protein 2684198 4207705 SFV_2612 Shigella flexneri 5 str. 8401 hypothetical protein YP_690014.1 2683575 R 373384 CDS YP_690015.1 110806495 4207706 complement(2684149..2685417) 1 NC_008258.1 tail fiber protein 2685417 4207706 SFV_2613 Shigella flexneri 5 str. 8401 tail fiber protein YP_690015.1 2684149 R 373384 CDS YP_690016.1 110806496 4207707 complement(2685441..2685986) 1 NC_008258.1 tail fiber assembly protein 2685986 4207707 SFV_2614 Shigella flexneri 5 str. 8401 tail fiber assembly protein YP_690016.1 2685441 R 373384 CDS YP_690017.1 110806497 4207708 complement(2686010..2686462) 1 NC_008258.1 IS1 encoded protein 2686462 4207708 SFV_2615 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690017.1 2686010 R 373384 CDS YP_690018.1 110806498 4207709 2686571..2686936 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 2686936 4207709 SFV_2616 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_690018.1 2686571 D 373384 CDS YP_690019.1 110806499 4207710 2686960..2687799 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 2687799 4207710 SFV_2617 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_690019.1 2686960 D 373384 CDS YP_690020.1 110806500 4207711 complement(2687724..2688710) 1 NC_008258.1 tail fiber protein 2688710 4207711 SFV_2618 Shigella flexneri 5 str. 8401 tail fiber protein YP_690020.1 2687724 R 373384 CDS YP_690021.1 110806501 4207712 complement(2688697..2689302) 1 NC_008258.1 hypothetical protein 2689302 4207712 SFV_2619 Shigella flexneri 5 str. 8401 hypothetical protein YP_690021.1 2688697 R 373384 CDS YP_690022.1 110806502 4207713 complement(2689313..2689990) 1 NC_008258.1 bacteriophage protein 2689990 4207713 SFV_2620 Shigella flexneri 5 str. 8401 bacteriophage protein YP_690022.1 2689313 R 373384 CDS YP_690023.1 110806503 4207714 2690070..2690372 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 2690372 4207714 SFV_2621 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690023.1 2690070 D 373384 CDS YP_690024.1 110806504 4207715 2690513..2691226 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2691226 4207715 SFV_2622 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_690024.1 2690513 D 373384 CDS YP_690025.1 110806505 4207716 complement(2691267..2692367) 1 NC_008258.1 hypothetical protein 2692367 4207716 SFV_2623 Shigella flexneri 5 str. 8401 hypothetical protein YP_690025.1 2691267 R 373384 CDS YP_690026.1 110806506 4207717 complement(2692905..2693408) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2693408 insB 4207717 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690026.1 2692905 R 373384 CDS YP_690027.1 110806507 4207718 2693483..2693668 1 NC_008258.1 IS1 encoded protein 2693668 4207718 SFV_2625 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690027.1 2693483 D 373384 CDS YP_690028.1 110806508 4207719 complement(2694313..2694693) 1 NC_008258.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2694693 acpS 4207719 acpS Shigella flexneri 5 str. 8401 4'-phosphopantetheinyl transferase YP_690028.1 2694313 R 373384 CDS YP_690029.1 110806509 4207284 complement(2694693..2695424) 1 NC_008258.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2695424 pdxJ 4207284 pdxJ Shigella flexneri 5 str. 8401 pyridoxine 5'-phosphate synthase YP_690029.1 2694693 R 373384 CDS YP_690030.1 110806510 4207285 complement(2695436..2696164) 1 NC_008258.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2696164 recO 4207285 recO Shigella flexneri 5 str. 8401 DNA repair protein RecO YP_690030.1 2695436 R 373384 CDS YP_690031.1 110806511 4207286 complement(2696176..2697081) 1 NC_008258.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2697081 era 4207286 era Shigella flexneri 5 str. 8401 GTP-binding protein Era YP_690031.1 2696176 R 373384 CDS YP_690032.1 110806512 4207287 complement(2697078..2697758) 1 NC_008258.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2697758 rnc 4207287 rnc Shigella flexneri 5 str. 8401 ribonuclease III YP_690032.1 2697078 R 373384 CDS YP_690033.1 110806513 4207288 complement(2698030..2699004) 1 NC_008258.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2699004 lepB 4207288 lepB Shigella flexneri 5 str. 8401 signal peptidase I YP_690033.1 2698030 R 373384 CDS YP_690034.1 110806514 4207289 complement(2699020..2700819) 1 NC_008258.1 may be inner membrane protein; binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2700819 lepA 4207289 lepA Shigella flexneri 5 str. 8401 GTP-binding protein LepA YP_690034.1 2699020 R 373384 CDS YP_690035.1 110806515 4207290 complement(2701017..2701496) 1 NC_008258.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2701496 rseC 4207290 rseC Shigella flexneri 5 str. 8401 SoxR reducing system protein RseC YP_690035.1 2701017 R 373384 CDS YP_690036.1 110806516 4207291 complement(2701493..2702449) 1 NC_008258.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2702449 rseB 4207291 rseB Shigella flexneri 5 str. 8401 periplasmic negative regulator of sigmaE YP_690036.1 2701493 R 373384 CDS YP_690037.1 110806517 4207292 complement(2702449..2703099) 1 NC_008258.1 Code: T; COG: COG3073; anti-RNA polymerase sigma factor SigE 2703099 rseA 4207292 rseA Shigella flexneri 5 str. 8401 anti-RNA polymerase sigma factor SigE YP_690037.1 2702449 R 373384 CDS YP_690038.1 110806518 4207293 complement(2703132..2703707) 1 NC_008258.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2703707 rpoE 4207293 rpoE Shigella flexneri 5 str. 8401 RNA polymerase sigma factor RpoE YP_690038.1 2703132 R 373384 CDS YP_690039.1 110806519 4207295 complement(2705722..2706579) 1 NC_008258.1 Code: R; COG: COG4123; hypothetical protein 2706579 yfiC 4207295 yfiC Shigella flexneri 5 str. 8401 hypothetical protein YP_690039.1 2705722 R 373384 CDS YP_690040.1 110806520 4207296 2706591..2707925 1 NC_008258.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2707925 srmB 4207296 srmB Shigella flexneri 5 str. 8401 ATP-dependent RNA helicase SrmB YP_690040.1 2706591 D 373384 CDS YP_690041.1 110806521 4207297 complement(2707960..2708886) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 2708886 yfiE 4207297 yfiE Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_690041.1 2707960 R 373384 CDS YP_690042.1 110806522 4207298 2708944..2709531 1 NC_008258.1 Code: E; COG: COG1280; neutral amino-acid efflux protein 2709531 yfiK 4207298 yfiK Shigella flexneri 5 str. 8401 neutral amino-acid efflux protein YP_690042.1 2708944 D 373384 CDS YP_690043.1 110806523 4207299 complement(2709587..2709970) 1 NC_008258.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2709970 yfiD 4207299 yfiD Shigella flexneri 5 str. 8401 autonomous glycyl radical cofactor GrcA YP_690043.1 2709587 R 373384 CDS YP_690044.1 110806524 4207300 2710275..2710964 1 NC_008258.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2710964 ung 4207300 ung Shigella flexneri 5 str. 8401 uracil-DNA glycosylase YP_690044.1 2710275 D 373384 CDS YP_690045.1 110806525 4207301 complement(2711012..2712049) 1 NC_008258.1 Code: J; COG: COG0566; methyltransferase 2712049 yfiF 4207301 yfiF Shigella flexneri 5 str. 8401 methyltransferase YP_690045.1 2711012 R 373384 CDS YP_690046.1 110806526 4207302 2712256..2712675 1 NC_008258.1 Code: OC; COG: COG0526; thioredoxin 2712675 trxC 4207302 trxC Shigella flexneri 5 str. 8401 thioredoxin YP_690046.1 2712256 D 373384 CDS YP_690047.1 110806527 4207303 2712693..2713442 1 NC_008258.1 Code: S; COG: COG3148; hypothetical protein 2713442 yfiP 4207303 yfiP Shigella flexneri 5 str. 8401 hypothetical protein YP_690047.1 2712693 D 373384 CDS YP_690048.1 110806528 4208692 2713474..2716134 1 NC_008258.1 Code: C; COG: COG1042; hypothetical protein 2716134 yfiQ 4208692 yfiQ Shigella flexneri 5 str. 8401 hypothetical protein YP_690048.1 2713474 D 373384 CDS YP_690049.1 110806529 4208693 2716248..2717603 1 NC_008258.1 phospholipid synthesis; catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2717603 pssA 4208693 pssA Shigella flexneri 5 str. 8401 phosphatidylserine synthase YP_690049.1 2716248 D 373384 CDS YP_690050.1 110806530 4208694 2717649..2717972 1 NC_008258.1 Code: R; COG: COG5544; hypothetical protein 2717972 yfiM 4208694 yfiM Shigella flexneri 5 str. 8401 hypothetical protein YP_690050.1 2717649 D 373384 CDS YP_690051.1 110806531 4208695 complement(2717969..2719267) 1 NC_008258.1 Code: GEPR; COG: COG0477; alpha-ketoglutarate transporter 2719267 kgtP 4208695 kgtP Shigella flexneri 5 str. 8401 alpha-ketoglutarate transporter YP_690051.1 2717969 R 373384 CDS YP_690052.1 110806532 4208700 2725101..2725841 1 NC_008258.1 IS4 orf 2725841 4208700 SFV_2655 Shigella flexneri 5 str. 8401 IS4 orf YP_690052.1 2725101 D 373384 CDS YP_690053.1 110806533 4208701 2725810..2726448 1 NC_008258.1 IS4 orf 2726448 4208701 SFV_2656 Shigella flexneri 5 str. 8401 IS4 orf YP_690053.1 2725810 D 373384 CDS YP_690054.1 110806534 4208702 complement(2726499..2727236) 1 NC_008258.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2727236 4208702 SFV_2657 Shigella flexneri 5 str. 8401 outer membrane protein assembly complex subunit YfiO YP_690054.1 2726499 R 373384 CDS YP_690055.1 110806535 4208703 2727371..2728351 1 NC_008258.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2728351 rluD 4208703 rluD Shigella flexneri 5 str. 8401 23S rRNA pseudouridine synthase D YP_690055.1 2727371 D 373384 CDS YP_690056.1 110806536 4208704 2728348..2729079 1 NC_008258.1 Code: S; COG: COG1496; hypothetical protein 2729079 yfiH 4208704 yfiH Shigella flexneri 5 str. 8401 hypothetical protein YP_690056.1 2728348 D 373384 CDS YP_690057.1 110806537 4208705 2729209..2731782 1 NC_008258.1 Code: O; COG: COG0542; protein disaggregation chaperone 2731782 clpB 4208705 clpB Shigella flexneri 5 str. 8401 protein disaggregation chaperone YP_690057.1 2729209 D 373384 CDS YP_690058.1 110806538 4208706 complement(2731819..2733165) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 2733165 4208706 SFV_2661 Shigella flexneri 5 str. 8401 IS4 orf YP_690058.1 2731819 R 373384 CDS YP_690059.1 110806539 4209213 complement(2733249..2734577) 1 NC_008258.1 Code: R; COG: COG1611; hypothetical protein 2734577 ygdH 4209213 ygdH Shigella flexneri 5 str. 8401 hypothetical protein YP_690059.1 2733249 R 373384 CDS YP_690060.1 110806540 4209214 complement(2734725..2735573) 1 NC_008258.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 2735573 queF 4209214 queF Shigella flexneri 5 str. 8401 7-cyano-7-deazaguanine reductase YP_690060.1 2734725 R 373384 CDS YP_690061.1 110806541 4209215 2735641..2736186 1 NC_008258.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 2736186 syd 4209215 syd Shigella flexneri 5 str. 8401 SecY interacting protein Syd YP_690061.1 2735641 D 373384 CDS YP_690062.1 110806542 4209216 2736808..2737137 1 NC_008258.1 Code: S; COG: COG3098; hypothetical protein 2737137 4209216 SFV_2665 Shigella flexneri 5 str. 8401 hypothetical protein YP_690062.1 2736808 D 373384 CDS YP_690063.1 110806543 4209217 2737137..2737919 1 NC_008258.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 2737919 yqcB 4209217 yqcB Shigella flexneri 5 str. 8401 tRNA pseudouridine synthase C YP_690063.1 2737137 D 373384 CDS YP_690064.1 110806544 4209218 2737937..2738386 1 NC_008258.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 2738386 4209218 SFV_2667 Shigella flexneri 5 str. 8401 flavodoxin YP_690064.1 2737937 D 373384 CDS YP_690065.1 110806545 4209219 2738820..2740172 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 2740172 4209219 SFV_2668 Shigella flexneri 5 str. 8401 transport protein YP_690065.1 2738820 D 373384 CDS YP_690066.1 110806546 4209220 2740174..2741514 1 NC_008258.1 Code: MR; COG: COG4948; glucarate dehydratase 2741514 ygcY 4209220 ygcY Shigella flexneri 5 str. 8401 glucarate dehydratase YP_690066.1 2740174 D 373384 CDS YP_690067.1 110806547 4209221 2741535..2742875 1 NC_008258.1 Code: MR; COG: COG4948; glucarate dehydratase 2742875 ygcX 4209221 ygcX Shigella flexneri 5 str. 8401 glucarate dehydratase YP_690067.1 2741535 D 373384 CDS YP_690068.1 110806548 4209222 complement(2743107..2745863) 1 NC_008258.1 activates OmpR by phophorylation; part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system; hybrid sensory histidine kinase BarA 2745863 barA 4209222 barA Shigella flexneri 5 str. 8401 hybrid sensory histidine kinase BarA YP_690068.1 2743107 R 373384 CDS YP_690069.1 110806549 4209223 2745920..2747221 1 NC_008258.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 2747221 rumA 4209223 rumA Shigella flexneri 5 str. 8401 23S rRNA 5-methyluridine methyltransferase YP_690069.1 2745920 D 373384 CDS YP_690070.1 110806550 4209224 2747269..2749503 1 NC_008258.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 2749503 relA 4209224 relA Shigella flexneri 5 str. 8401 GDP/GTP pyrophosphokinase YP_690070.1 2747269 D 373384 CDS YP_690071.1 110806551 4209225 2749599..2750390 1 NC_008258.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 2750390 mazG 4209225 mazG Shigella flexneri 5 str. 8401 nucleoside triphosphate pyrophosphohydrolase YP_690071.1 2749599 D 373384 CDS YP_690072.1 110806552 4209226 2750618..2752255 1 NC_008258.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 2752255 pyrG 4209226 pyrG Shigella flexneri 5 str. 8401 CTP synthetase YP_690072.1 2750618 D 373384 CDS YP_690073.1 110806553 4209227 2752343..2753638 1 NC_008258.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 2753638 eno 4209227 eno Shigella flexneri 5 str. 8401 phosphopyruvate hydratase YP_690073.1 2752343 D 373384 CDS YP_690074.1 110806554 4209228 complement(2753698..2754570) 1 NC_008258.1 Code: R; COG: COG1512; hypothetical protein 2754570 ygcG 4209228 ygcG Shigella flexneri 5 str. 8401 hypothetical protein YP_690074.1 2753698 R 373384 CDS YP_690075.1 110806555 4209229 2754863..2755534 1 NC_008258.1 Code: O; COG: COG0602; hypothetical protein 2755534 ygcF 4209229 ygcF Shigella flexneri 5 str. 8401 hypothetical protein YP_690075.1 2754863 D 373384 CDS YP_690076.1 110806556 4209230 complement(2755573..2755866) 1 NC_008258.1 IS1 ORF2 2755866 insB 4209230 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690076.1 2755573 R 373384 CDS YP_690077.1 110806557 4209231 complement(2755903..2756076) 1 NC_008258.1 IS1 ORF2 2756076 insB 4209231 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690077.1 2755903 R 373384 CDS YP_690078.1 110806558 4209232 2756190..2757179 1 NC_008258.1 hypothetical protein 2757179 4209232 SFV_2681 Shigella flexneri 5 str. 8401 hypothetical protein YP_690078.1 2756190 D 373384 CDS YP_690079.1 110806559 4208971 2757273..2758610 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 2758610 ygcS 4208971 ygcS Shigella flexneri 5 str. 8401 transport protein YP_690079.1 2757273 D 373384 CDS YP_690080.1 110806560 4208972 2758588..2759367 1 NC_008258.1 Code: C; COG: COG2086; transport protein 2759367 ygcR 4208972 ygcR Shigella flexneri 5 str. 8401 transport protein YP_690080.1 2758588 D 373384 CDS YP_690081.1 110806561 4208973 2759364..2760224 1 NC_008258.1 Code: C; COG: COG2025; flavoprotein 2760224 ygcQ 4208973 ygcQ Shigella flexneri 5 str. 8401 flavoprotein YP_690081.1 2759364 D 373384 CDS YP_690082.1 110806562 4208975 complement(2761161..2762120) 1 NC_008258.1 Code: L; COG: COG0582; integrase 2762120 4208975 SFV_2686 Shigella flexneri 5 str. 8401 integrase YP_690082.1 2761161 R 373384 CDS YP_690083.1 110806563 4208976 complement(2762026..2762739) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2762739 4208976 SFV_2687 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_690083.1 2762026 R 373384 CDS YP_690084.1 110806564 4208977 complement(2762880..2763182) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 2763182 4208977 SFV_2688 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690084.1 2762880 R 373384 CDS YP_690085.1 110806565 4208978 2763458..2766364 1 NC_008258.1 bacteriophage protein 2766364 4208978 SFV_2689 Shigella flexneri 5 str. 8401 bacteriophage protein YP_690085.1 2763458 D 373384 CDS YP_690086.1 110806566 4208979 2766527..2766715 1 NC_008258.1 bacteriophage protein 2766715 4208979 SFV_2690 Shigella flexneri 5 str. 8401 bacteriophage protein YP_690086.1 2766527 D 373384 CDS YP_690087.1 110806567 4208980 2766712..2767122 1 NC_008258.1 recombination protein 2767122 ninB 4208980 ninB Shigella flexneri 5 str. 8401 recombination protein YP_690087.1 2766712 D 373384 CDS YP_690088.1 110806569 4208982 complement(2767337..2767645) 1 NC_008258.1 hypothetical protein 2767645 4208982 SFV_2693 Shigella flexneri 5 str. 8401 hypothetical protein YP_690088.1 2767337 R 373384 CDS YP_690089.1 110806568 4208981 2767506..2768336 1 NC_008258.1 bacteriophage protein 2768336 4208981 SFV_2692 Shigella flexneri 5 str. 8401 bacteriophage protein YP_690089.1 2767506 D 373384 CDS YP_690090.1 110806570 4208983 2768463..2768846 1 NC_008258.1 hypothetical protein 2768846 4208983 SFV_2694 Shigella flexneri 5 str. 8401 hypothetical protein YP_690090.1 2768463 D 373384 CDS YP_690091.1 110806571 4208984 2769063..2769971 1 NC_008258.1 hypothetical protein 2769971 4208984 SFV_2695 Shigella flexneri 5 str. 8401 hypothetical protein YP_690091.1 2769063 D 373384 CDS YP_690092.1 110806572 4208985 2769982..2770860 1 NC_008258.1 Code: L; COG: COG1484; replication protein DnaC 2770860 4208985 SFV_2696 Shigella flexneri 5 str. 8401 replication protein DnaC YP_690092.1 2769982 D 373384 CDS YP_690093.1 110806573 4208986 2770857..2772248 1 NC_008258.1 Code: L; COG: COG0305; helicase 2772248 4208986 SFV_2697 Shigella flexneri 5 str. 8401 helicase YP_690093.1 2770857 D 373384 CDS YP_690094.1 110806574 4208987 2772245..2772502 1 NC_008258.1 bacteriophage protein 2772502 4208987 SFV_2698 Shigella flexneri 5 str. 8401 bacteriophage protein YP_690094.1 2772245 D 373384 CDS YP_690095.1 110806575 4208988 2772595..2772795 1 NC_008258.1 bacteriophage protein 2772795 4208988 SFV_2699 Shigella flexneri 5 str. 8401 bacteriophage protein YP_690095.1 2772595 D 373384 CDS YP_690096.1 110806576 4207947 2773971..2774186 1 NC_008258.1 hypothetical protein 2774186 4207947 SFV_2704 Shigella flexneri 5 str. 8401 hypothetical protein YP_690096.1 2773971 D 373384 CDS YP_690097.1 110806577 4207948 2774260..2774820 1 NC_008258.1 hypothetical protein 2774820 4207948 SFV_2705 Shigella flexneri 5 str. 8401 hypothetical protein YP_690097.1 2774260 D 373384 CDS YP_690098.1 110806578 4207949 2774886..2775419 1 NC_008258.1 Code: R; COG: COG3772; lysozyme 2775419 4207949 SFV_2706 Shigella flexneri 5 str. 8401 lysozyme YP_690098.1 2774886 D 373384 CDS YP_690099.1 110806579 4207950 2775416..2775883 1 NC_008258.1 endopeptidase 2775883 4207950 SFV_2707 Shigella flexneri 5 str. 8401 endopeptidase YP_690099.1 2775416 D 373384 CDS YP_690100.1 110806580 4207951 complement(2776309..2777022) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2777022 4207951 SFV_2708 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_690100.1 2776309 R 373384 CDS YP_690101.1 110806581 4207952 complement(2777163..2777465) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 2777465 4207952 SFV_2709 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690101.1 2777163 R 373384 CDS YP_690102.1 110806582 4207953 2779099..2779257 1 NC_008258.1 IS600 ORF1 2779257 4207953 SFV_2710 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690102.1 2779099 D 373384 CDS YP_690103.1 110806583 4207954 complement(2779260..2780147) 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 2780147 4207954 SFV_2711 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_690103.1 2779260 R 373384 CDS YP_690104.1 110806584 4207955 complement(2780147..2780473) 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 2780473 4207955 SFV_2712 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_690104.1 2780147 R 373384 CDS YP_690105.1 110806585 4207956 2780589..2780714 1 NC_008258.1 IS600 ORF1 2780714 4207956 SFV_2713 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690105.1 2780589 D 373384 CDS YP_690106.1 110806586 4207957 2780855..2781568 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2781568 4207957 SFV_2714 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_690106.1 2780855 D 373384 CDS YP_690107.1 110806587 4207958 2781596..2781919 1 NC_008258.1 Code: L; COG: COG4220; terminase small subunit 2781919 4207958 SFV_2715 Shigella flexneri 5 str. 8401 terminase small subunit YP_690107.1 2781596 D 373384 CDS YP_690108.1 110806588 4209766 2781891..2783819 1 NC_008258.1 terminase large subunit; Code: R; COG: COG5525; DNA packaging protein of prophage 2783819 4209766 SFV_2716 Shigella flexneri 5 str. 8401 DNA packaging protein of prophage YP_690108.1 2781891 D 373384 CDS YP_690109.1 110806589 4209767 2784003..2785058 1 NC_008258.1 Code: R; COG: COG5511; head-tail preconnector gp5 2785058 4209767 SFV_2717 Shigella flexneri 5 str. 8401 head-tail preconnector gp5 YP_690109.1 2784003 D 373384 CDS YP_690110.1 110806590 4209768 2785111..2785596 1 NC_008258.1 head-tail preconnector gp5 2785596 4209768 SFV_2718 Shigella flexneri 5 str. 8401 head-tail preconnector gp5 YP_690110.1 2785111 D 373384 CDS YP_690111.1 110806591 4209769 2785586..2787091 1 NC_008258.1 Code: OU; COG: COG0616; head-tail preconnector gp5 2787091 4209769 SFV_2719 Shigella flexneri 5 str. 8401 head-tail preconnector gp5 YP_690111.1 2785586 D 373384 CDS YP_690112.1 110806592 4209770 2787128..2787475 1 NC_008258.1 capsid protein small subunit 2787475 4209770 SFV_2720 Shigella flexneri 5 str. 8401 capsid protein small subunit YP_690112.1 2787128 D 373384 CDS YP_690113.1 110806593 4209771 2787533..2788561 1 NC_008258.1 major capsid protein 2788561 4209771 SFV_2721 Shigella flexneri 5 str. 8401 major capsid protein YP_690113.1 2787533 D 373384 CDS YP_690114.1 110806594 4209772 2788613..2788999 1 NC_008258.1 DNA-packaging protein 2788999 4209772 SFV_2722 Shigella flexneri 5 str. 8401 DNA-packaging protein YP_690114.1 2788613 D 373384 CDS YP_690115.1 110806595 4209773 2789011..2789364 1 NC_008258.1 tail attachment protein 2789364 4209773 SFV_2723 Shigella flexneri 5 str. 8401 tail attachment protein YP_690115.1 2789011 D 373384 CDS YP_690116.1 110806596 4209774 2789374..2789955 1 NC_008258.1 tail component of prophage 2789955 4209774 SFV_2724 Shigella flexneri 5 str. 8401 tail component of prophage YP_690116.1 2789374 D 373384 CDS YP_690117.1 110806597 4209775 2789952..2790353 1 NC_008258.1 tail component of prophage 2790353 4209775 SFV_2725 Shigella flexneri 5 str. 8401 tail component of prophage YP_690117.1 2789952 D 373384 CDS YP_690118.1 110806598 4209776 2790364..2791104 1 NC_008258.1 Code: N; COG: COG5492; tail component of prophage 2791104 4209776 SFV_2726 Shigella flexneri 5 str. 8401 tail component of prophage YP_690118.1 2790364 D 373384 CDS YP_690119.1 110806599 4209777 2791163..2791549 1 NC_008258.1 tail component of prophage 2791549 4209777 SFV_2727 Shigella flexneri 5 str. 8401 tail component of prophage YP_690119.1 2791163 D 373384 CDS YP_690120.1 110806600 4209778 2791558..2791887 1 NC_008258.1 tail component of prophage 2791887 4209778 SFV_2728 Shigella flexneri 5 str. 8401 tail component of prophage YP_690120.1 2791558 D 373384 CDS YP_690121.1 110806601 4209780 2794901..2795842 1 NC_008258.1 Code: S; COG: COG4672; minor tail protein 2795842 4209780 SFV_2730 Shigella flexneri 5 str. 8401 minor tail protein YP_690121.1 2794901 D 373384 CDS YP_690122.1 110806602 4209781 2795778..2796590 1 NC_008258.1 tail assembly protein 2796590 4209781 SFV_2731 Shigella flexneri 5 str. 8401 tail assembly protein YP_690122.1 2795778 D 373384 CDS YP_690123.1 110806603 4209782 2796554..2797129 1 NC_008258.1 Code: S; COG: COG4723; tail component of prophage 2797129 4209782 SFV_2732 Shigella flexneri 5 str. 8401 tail component of prophage YP_690123.1 2796554 D 373384 CDS YP_690124.1 110806604 4209783 2797190..2800669 1 NC_008258.1 Code: S; COG: COG4733; host specificity protein 2800669 4209783 SFV_2733 Shigella flexneri 5 str. 8401 host specificity protein YP_690124.1 2797190 D 373384 CDS YP_690125.1 110806605 4209784 2800737..2801336 1 NC_008258.1 Code: M; COG: COG3637; hypothetical protein 2801336 4209784 SFV_2734 Shigella flexneri 5 str. 8401 hypothetical protein YP_690125.1 2800737 D 373384 CDS YP_690126.1 110806606 4209785 2801400..2802815 1 NC_008258.1 phage tail fiber protein 2802815 4209785 SFV_2735 Shigella flexneri 5 str. 8401 phage tail fiber protein YP_690126.1 2801400 D 373384 CDS YP_690127.1 110806607 4210386 2802766..2803389 1 NC_008258.1 hypothetical protein 2803389 4210386 SFV_2736 Shigella flexneri 5 str. 8401 hypothetical protein YP_690127.1 2802766 D 373384 CDS YP_690128.1 110806608 4210387 complement(2803569..2805332) 1 NC_008258.1 Code: S; COG: COG4886; invasion plasmid antigen 2805332 ipaH_7 4210387 ipaH_7 Shigella flexneri 5 str. 8401 invasion plasmid antigen YP_690128.1 2803569 R 373384 CDS YP_690129.1 110806609 4210388 complement(2805816..2806112) 1 NC_008258.1 Code: C; COG: COG2440; hypothetical protein 2806112 ygcO 4210388 ygcO Shigella flexneri 5 str. 8401 hypothetical protein YP_690129.1 2805816 R 373384 CDS YP_690130.1 110806610 4210389 complement(2806067..2807338) 1 NC_008258.1 Code: C; COG: COG0644; hypothetical protein 2807338 ygcN 4210389 ygcN Shigella flexneri 5 str. 8401 hypothetical protein YP_690130.1 2806067 R 373384 CDS YP_690131.1 110806611 4210390 complement(2807416..2807865) 1 NC_008258.1 Code: H; COG: COG0720; 6-pyruvoyl tetrahydrobiopterin synthase 2807865 ygcM 4210390 ygcM Shigella flexneri 5 str. 8401 6-pyruvoyl tetrahydrobiopterin synthase YP_690131.1 2807416 R 373384 CDS YP_690132.1 110806612 4210391 2808097..2809896 1 NC_008258.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 2809896 cysJ 4210391 cysJ Shigella flexneri 5 str. 8401 sulfite reductase subunit alpha YP_690132.1 2808097 D 373384 CDS YP_690133.1 110806613 4210392 2809896..2811608 1 NC_008258.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2811608 cysI 4210392 cysI Shigella flexneri 5 str. 8401 sulfite reductase subunit beta YP_690133.1 2809896 D 373384 CDS YP_690134.1 110806614 4210393 2811682..2812416 1 NC_008258.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2812416 cysH 4210393 cysH Shigella flexneri 5 str. 8401 phosphoadenosine phosphosulfate reductase YP_690134.1 2811682 D 373384 CDS YP_690135.1 110806615 4210394 2813068..2814177 1 NC_008258.1 hypothetical protein 2814177 4210394 SFV_2744 Shigella flexneri 5 str. 8401 hypothetical protein YP_690135.1 2813068 D 373384 CDS YP_690136.1 110806616 4210395 complement(2814263..2815300) 1 NC_008258.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 2815300 iap 4210395 iap Shigella flexneri 5 str. 8401 alkaline phosphatase YP_690136.1 2814263 R 373384 CDS YP_690137.1 110806617 4210396 2815552..2816460 1 NC_008258.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2816460 cysD 4210396 cysD Shigella flexneri 5 str. 8401 sulfate adenylyltransferase subunit 2 YP_690137.1 2815552 D 373384 CDS YP_690138.1 110806618 4210397 2816462..2817889 1 NC_008258.1 probably a GTPase; may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 2817889 cysN 4210397 cysN Shigella flexneri 5 str. 8401 sulfate adenylyltransferase subunit 1 YP_690138.1 2816462 D 373384 CDS YP_690139.1 110806619 4210398 2817889..2818494 1 NC_008258.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 2818494 cysC 4210398 cysC Shigella flexneri 5 str. 8401 adenylylsulfate kinase YP_690139.1 2817889 D 373384 CDS YP_690140.1 110806620 4210399 2818544..2818867 1 NC_008258.1 hypothetical protein 2818867 ygbE 4210399 ygbE Shigella flexneri 5 str. 8401 hypothetical protein YP_690140.1 2818544 D 373384 CDS YP_690141.1 110806621 4210400 2819061..2819372 1 NC_008258.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 2819372 ftsB 4210400 ftsB Shigella flexneri 5 str. 8401 cell division protein FtsB YP_690141.1 2819061 D 373384 CDS YP_690142.1 110806622 4210401 2819391..2820101 1 NC_008258.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2820101 ispD 4210401 ispD Shigella flexneri 5 str. 8401 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_690142.1 2819391 D 373384 CDS YP_690143.1 110806623 4210402 2820101..2820580 1 NC_008258.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2820580 ispF 4210402 ispF Shigella flexneri 5 str. 8401 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_690143.1 2820101 D 373384 CDS YP_690144.1 110806624 4210403 2820577..2821626 1 NC_008258.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2821626 truD 4210403 truD Shigella flexneri 5 str. 8401 tRNA pseudouridine synthase D YP_690144.1 2820577 D 373384 CDS YP_690145.1 110806625 4210404 2821562..2822368 1 NC_008258.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2822368 surE 4210404 surE Shigella flexneri 5 str. 8401 stationary phase survival protein SurE YP_690145.1 2821562 D 373384 CDS YP_690146.1 110806626 4210346 2822362..2822988 1 NC_008258.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 2822988 pcm 4210346 pcm Shigella flexneri 5 str. 8401 protein-L-isoaspartate O-methyltransferase YP_690146.1 2822362 D 373384 CDS YP_690147.1 110806627 4210347 2823128..2824267 1 NC_008258.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 2824267 nlpD 4210347 nlpD Shigella flexneri 5 str. 8401 lipoprotein NlpD YP_690147.1 2823128 D 373384 CDS YP_690148.1 110806628 4210348 2824330..2825322 1 NC_008258.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 2825322 rpoS 4210348 rpoS Shigella flexneri 5 str. 8401 RNA polymerase sigma factor RpoS YP_690148.1 2824330 D 373384 CDS YP_690149.1 110806629 4210349 complement(2825442..2825849) 1 NC_008258.1 Code: K; COG: COG1846; transcriptional regulator 2825849 4210349 SFV_2758 Shigella flexneri 5 str. 8401 transcriptional regulator YP_690149.1 2825442 R 373384 CDS YP_690150.1 110806630 4210350 2825996..2826589 1 NC_008258.1 Code: H; COG: COG0163; phenylacrylic acid decarboxylase-like protein 2826589 4210350 SFV_2759 Shigella flexneri 5 str. 8401 phenylacrylic acid decarboxylase-like protein YP_690150.1 2825996 D 373384 CDS YP_690151.1 110806631 4210351 2826589..2827539 1 NC_008258.1 Code: H; COG: COG0043; 4-hydroxybenzoate decarboxylase 2827539 yclC 4210351 yclC Shigella flexneri 5 str. 8401 4-hydroxybenzoate decarboxylase YP_690151.1 2826589 D 373384 CDS YP_690152.1 110806632 4210352 complement(2827809..2828372) 1 NC_008258.1 regulatory protein 2828372 4210352 SFV_2761 Shigella flexneri 5 str. 8401 regulatory protein YP_690152.1 2827809 R 373384 CDS YP_690153.1 110806633 4210353 2828790..2830811 1 NC_008258.1 Code: L; COG: COG2801; phage transposase 2830811 4210353 SFV_2762 Shigella flexneri 5 str. 8401 phage transposase YP_690153.1 2828790 D 373384 CDS YP_690154.1 110806634 4210354 complement(2830951..2831664) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 2831664 4210354 SFV_2763 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_690154.1 2830951 R 373384 CDS YP_690155.1 110806635 4210355 complement(2831819..2832031) 1 NC_008258.1 IS1 encoded protein 2832031 4210355 SFV_2764 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690155.1 2831819 R 373384 CDS YP_690156.1 110806636 4210356 2832106..2832609 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2832609 insB 4210356 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690156.1 2832106 D 373384 CDS YP_690157.1 110806637 4210357 complement(2832603..2832884) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 2832884 4210357 SFV_2766 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690157.1 2832603 R 373384 CDS YP_690158.1 110806638 4210358 complement(2833166..2834074) 1 NC_008258.1 Code: I; COG: COG2084; dehydrogenase 2834074 4210358 SFV_2767 Shigella flexneri 5 str. 8401 dehydrogenase YP_690158.1 2833166 R 373384 CDS YP_690159.1 110806639 4210359 2834306..2835037 1 NC_008258.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 2835037 ygbI 4210359 ygbI Shigella flexneri 5 str. 8401 DeoR-type transcriptional regulator YP_690159.1 2834306 D 373384 CDS YP_690160.1 110806640 4210361 complement(2835846..2838407) 1 NC_008258.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2838407 mutS 4210361 mutS Shigella flexneri 5 str. 8401 DNA mismatch repair protein MutS YP_690160.1 2835846 R 373384 CDS YP_690161.1 110806641 4210362 2838694..2839047 1 NC_008258.1 hypothetical protein 2839047 ygbA 4210362 ygbA Shigella flexneri 5 str. 8401 hypothetical protein YP_690161.1 2838694 D 373384 CDS YP_690162.1 110806642 4210363 complement(2839084..2841162) 1 NC_008258.1 Code: KT; COG: COG3604; formate hydrogen-lyase transcriptional activator 2841162 fhlA 4210363 fhlA Shigella flexneri 5 str. 8401 formate hydrogen-lyase transcriptional activator YP_690162.1 2839084 R 373384 CDS YP_690163.1 110806643 4210364 complement(2841236..2842204) 1 NC_008258.1 plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309; hypothetical protein 2842204 hypE 4210364 hypE Shigella flexneri 5 str. 8401 hypothetical protein YP_690163.1 2841236 R 373384 CDS YP_690164.1 110806644 4210365 complement(2842243..2843364) 1 NC_008258.1 pleiotrophic effects on 3 hydrogenase isozymes; Code: O; COG: COG0409; hydrogenase isoenzyme HypD 2843364 hypD 4210365 hypD Shigella flexneri 5 str. 8401 hydrogenase isoenzyme HypD YP_690164.1 2842243 R 373384 CDS YP_690165.1 110806645 4209080 complement(2843364..2843636) 1 NC_008258.1 pleiotrophic effects on 3 hydrogenase isozymes; HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 2843636 hypC 4209080 hypC Shigella flexneri 5 str. 8401 hydrogenase assembly chaperone YP_690165.1 2843364 R 373384 CDS YP_690166.1 110806646 4209081 complement(2843627..2844499) 1 NC_008258.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 2844499 hypB 4209081 hypB Shigella flexneri 5 str. 8401 hydrogenase nickel incorporation protein HypB YP_690166.1 2843627 R 373384 CDS YP_690167.1 110806647 4209082 complement(2844503..2844853) 1 NC_008258.1 pleiotrophic effects on 3 hydrogenase isozymes; plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 2844853 hypA 4209082 hypA Shigella flexneri 5 str. 8401 hydrogenase nickel incorporation protein YP_690167.1 2844503 R 373384 CDS YP_690168.1 110806648 4209083 2845065..2845526 1 NC_008258.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 2845526 hycA 4209083 hycA Shigella flexneri 5 str. 8401 formate hydrogenlyase regulatory protein HycA YP_690168.1 2845065 D 373384 CDS YP_690169.1 110806649 4209084 2845651..2846262 1 NC_008258.1 Code: C; COG: COG1142; small subunit of hydrogenase-3, iron-sulfur protein 2846262 hycB 4209084 hycB Shigella flexneri 5 str. 8401 small subunit of hydrogenase-3, iron-sulfur protein YP_690169.1 2845651 D 373384 CDS YP_690170.1 110806650 4209085 2846431..2847969 1 NC_008258.1 Code: CP; COG: COG0651; formate hydrogenlyase subunit 3 2847969 hycC 4209085 hycC Shigella flexneri 5 str. 8401 formate hydrogenlyase subunit 3 YP_690170.1 2846431 D 373384 CDS YP_690171.1 110806651 4209086 2847972..2848895 1 NC_008258.1 Code: C; COG: COG0650; hydrogenase 3 membrane-spanning protein 2848895 hycD 4209086 hycD Shigella flexneri 5 str. 8401 hydrogenase 3 membrane-spanning protein YP_690171.1 2847972 D 373384 CDS YP_690172.1 110806652 4209087 2848913..2850622 1 NC_008258.1 Code: C; COG: COG3261; large subunit of hydrogenase 3 (part of FHL complex) 2850622 hycE 4209087 hycE Shigella flexneri 5 str. 8401 large subunit of hydrogenase 3 (part of FHL complex) YP_690172.1 2848913 D 373384 CDS YP_690173.1 110806653 4209088 2850632..2851174 1 NC_008258.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 2851174 hycF 4209088 hycF Shigella flexneri 5 str. 8401 formate hydrogenlyase complex iron-sulfur subunit YP_690173.1 2850632 D 373384 CDS YP_690174.1 110806654 4209089 2851174..2851941 1 NC_008258.1 Code: C; COG: COG3260; hydrogenase activity 2851941 hycG 4209089 hycG Shigella flexneri 5 str. 8401 hydrogenase activity YP_690174.1 2851174 D 373384 CDS YP_690175.1 110806655 4209090 2851938..2852348 1 NC_008258.1 hydrogenase 3 large subunit processing protein 2852348 hycH 4209090 hycH Shigella flexneri 5 str. 8401 hydrogenase 3 large subunit processing protein YP_690175.1 2851938 D 373384 CDS YP_690176.1 110806656 4209091 2852374..2852811 1 NC_008258.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 2852811 hycI 4209091 hycI Shigella flexneri 5 str. 8401 hydrogenase 3 maturation protease YP_690176.1 2852374 D 373384 CDS YP_690177.1 110806657 4209092 2852836..2853597 1 NC_008258.1 periplasmic or exported protein 2853597 4209092 SFV_2787 Shigella flexneri 5 str. 8401 periplasmic or exported protein YP_690177.1 2852836 D 373384 CDS YP_690178.1 110806658 4209093 2854077..2854496 1 NC_008258.1 Code: K; COG: COG5499; hypothetical protein 2854496 4209093 SFV_2788 Shigella flexneri 5 str. 8401 hypothetical protein YP_690178.1 2854077 D 373384 CDS YP_690179.1 110806659 4209094 complement(2854611..2856035) 1 NC_008258.1 Code: G; COG: COG2723; cryptic 6-phospho-beta-glucosidase 2856035 ascB 4209094 ascB Shigella flexneri 5 str. 8401 cryptic 6-phospho-beta-glucosidase YP_690179.1 2854611 R 373384 CDS YP_690180.1 110806660 4209095 complement(2856044..2857501) 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC 2857501 ascF 4209095 ascF Shigella flexneri 5 str. 8401 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC YP_690180.1 2856044 R 373384 CDS YP_690181.1 110806661 4209096 2857758..2858771 1 NC_008258.1 Code: K; COG: COG1609; ascBF operon repressor 2858771 ascG 4209096 ascG Shigella flexneri 5 str. 8401 ascBF operon repressor YP_690181.1 2857758 D 373384 CDS YP_690182.1 110806662 4209097 2858920..2859447 1 NC_008258.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 2859447 hydN 4209097 hydN Shigella flexneri 5 str. 8401 electron transport protein HydN YP_690182.1 2858920 D 373384 CDS YP_690183.1 110806663 4209098 2859600..2861852 1 NC_008258.1 Code: O; COG: COG0068; transcriptional regulatory protein 2861852 hypF 4209098 hypF Shigella flexneri 5 str. 8401 transcriptional regulatory protein YP_690183.1 2859600 D 373384 CDS YP_690184.1 110806664 4207926 complement(2861980..2863113) 1 NC_008258.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 2863113 ygbD 4207926 ygbD Shigella flexneri 5 str. 8401 nitric oxide reductase YP_690184.1 2861980 R 373384 CDS YP_690185.1 110806665 4207927 complement(2863110..2864549) 1 NC_008258.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 2864549 4207927 SFV_2795 Shigella flexneri 5 str. 8401 anaerobic nitric oxide reductase flavorubredoxin YP_690185.1 2863110 R 373384 CDS YP_690186.1 110806666 4207928 2864736..2866250 1 NC_008258.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcription regulator 2866250 ygaA 4207928 ygaA Shigella flexneri 5 str. 8401 anaerobic nitric oxide reductase transcription regulator YP_690186.1 2864736 D 373384 CDS YP_690187.1 110806667 4207929 complement(2866247..2867212) 1 NC_008258.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 2867212 gutQ 4207929 gutQ Shigella flexneri 5 str. 8401 D-arabinose 5-phosphate isomerase YP_690187.1 2866247 R 373384 CDS YP_690188.1 110806668 4207930 complement(2867205..2867978) 1 NC_008258.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 2867978 srlR 4207930 srlR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor SrlR YP_690188.1 2867205 R 373384 CDS YP_690189.1 110806669 4207931 complement(2868045..2868404) 1 NC_008258.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 2868404 gutM 4207931 gutM Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator GutM YP_690189.1 2868045 R 373384 CDS YP_690190.1 110806670 4207932 complement(2868509..2869288) 1 NC_008258.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 2869288 srlD 4207932 srlD Shigella flexneri 5 str. 8401 sorbitol-6-phosphate dehydrogenase YP_690190.1 2868509 R 373384 CDS YP_690191.1 110806671 4207933 complement(2869292..2869663) 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 2869663 srlB 4207933 srlB Shigella flexneri 5 str. 8401 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_690191.1 2869292 R 373384 CDS YP_690192.1 110806672 4207935 complement(2870629..2871192) 1 NC_008258.1 Code: G; COG: COG3730; PTS system glucitol/sorbitol-specific transporter subunit IIC 2871192 srlA 4207935 srlA Shigella flexneri 5 str. 8401 PTS system glucitol/sorbitol-specific transporter subunit IIC YP_690192.1 2870629 R 373384 CDS YP_690193.1 110806673 4207936 2871388..2872533 1 NC_008258.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 2872533 mltB 4207936 mltB Shigella flexneri 5 str. 8401 murein hydrolase B YP_690193.1 2871388 D 373384 CDS YP_690194.1 110806674 4207937 2872678..2873175 1 NC_008258.1 Code: R; COG: COG1546; competence damage-inducible protein A 2873175 ygaD 4207937 ygaD Shigella flexneri 5 str. 8401 competence damage-inducible protein A YP_690194.1 2872678 D 373384 CDS YP_690195.1 110806675 4207938 2873255..2874316 1 NC_008258.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 2874316 recA 4207938 recA Shigella flexneri 5 str. 8401 recombinase A YP_690195.1 2873255 D 373384 CDS YP_690196.1 110806676 4207939 2874559..2875059 1 NC_008258.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2875059 recX 4207939 recX Shigella flexneri 5 str. 8401 recombination regulator RecX YP_690196.1 2874559 D 373384 CDS YP_690197.1 110806677 4207940 2875187..2877817 1 NC_008258.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2877817 alaS 4207940 alaS Shigella flexneri 5 str. 8401 alanyl-tRNA synthetase YP_690197.1 2875187 D 373384 CDS YP_690198.1 110806678 4207941 2878052..2878237 1 NC_008258.1 controls glycogen synthesis, gluconeogenesis, cell size and surface properties; affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 2878237 csrA 4207941 csrA Shigella flexneri 5 str. 8401 carbon storage regulator YP_690198.1 2878052 D 373384 CDS YP_690199.1 110806679 4207065 2879155..2879721 1 NC_008258.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 2879721 yqaB 4207065 yqaB Shigella flexneri 5 str. 8401 fructose-1-phosphatase YP_690199.1 2879155 D 373384 CDS YP_690200.1 110806680 4207066 2879718..2880146 1 NC_008258.1 Code: S; COG: COG1238; hypothetical protein 2880146 4207066 SFV_2815 Shigella flexneri 5 str. 8401 hypothetical protein YP_690200.1 2879718 D 373384 CDS YP_690201.1 110806681 4207067 2880219..2881775 1 NC_008258.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 2881775 gshA 4207067 gshA Shigella flexneri 5 str. 8401 glutamate--cysteine ligase YP_690201.1 2880219 D 373384 CDS YP_690202.1 110806682 4207068 2881925..2882440 1 NC_008258.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 2882440 ygaG 4207068 ygaG Shigella flexneri 5 str. 8401 S-ribosylhomocysteinase YP_690202.1 2881925 D 373384 CDS YP_690203.1 110806683 4207069 complement(2882504..2884042) 1 NC_008258.1 Code: GEPR; COG: COG0477; multidrug resistant protein emrB 2884042 emrB 4207069 emrB Shigella flexneri 5 str. 8401 multidrug resistant protein emrB YP_690203.1 2882504 R 373384 CDS YP_690204.1 110806684 4207071 complement(2885358..2885888) 1 NC_008258.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 2885888 emrR 4207071 emrR Shigella flexneri 5 str. 8401 transcriptional repressor MprA YP_690204.1 2885358 R 373384 CDS YP_690205.1 110806685 4207072 complement(2885979..2886314) 1 NC_008258.1 hypothetical protein 2886314 ygaH 4207072 ygaH Shigella flexneri 5 str. 8401 hypothetical protein YP_690205.1 2885979 R 373384 CDS YP_690206.1 110806686 4207073 complement(2886304..2887041) 1 NC_008258.1 Code: E; COG: COG1296; hypothetical protein 2887041 4207073 SFV_2822 Shigella flexneri 5 str. 8401 hypothetical protein YP_690206.1 2886304 R 373384 CDS YP_690207.1 110806687 4207074 complement(2887385..2888305) 1 NC_008258.1 Code: GEPR; COG: COG0477; major facilitator superfamily permease 2888305 4207074 SFV_2823 Shigella flexneri 5 str. 8401 major facilitator superfamily permease YP_690207.1 2887385 R 373384 CDS YP_690208.1 110806688 4207075 complement(2888536..2889528) 1 NC_008258.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 2889528 proX 4207075 proX Shigella flexneri 5 str. 8401 glycine betaine transporter periplasmic subunit YP_690208.1 2888536 R 373384 CDS YP_690209.1 110806689 4207076 complement(2889586..2890650) 1 NC_008258.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 2890650 proW 4207076 proW Shigella flexneri 5 str. 8401 glycine betaine transporter membrane protein YP_690209.1 2889586 R 373384 CDS YP_690210.1 110806690 4207077 complement(2890643..2892046) 1 NC_008258.1 for glycine, betaine and proline; with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 2892046 proV 4207077 proV Shigella flexneri 5 str. 8401 glycine betaine transporter ATP-binding subunit YP_690210.1 2890643 R 373384 CDS YP_690211.1 110806691 4207078 complement(2892200..2893159) 1 NC_008258.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 2893159 nrdF 4207078 nrdF Shigella flexneri 5 str. 8401 ribonucleotide-diphosphate reductase subunit beta YP_690211.1 2892200 R 373384 CDS YP_690212.1 110806692 4207079 complement(2893169..2895313) 1 NC_008258.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2895313 nrdE 4207079 nrdE Shigella flexneri 5 str. 8401 ribonucleotide-diphosphate reductase subunit alpha YP_690212.1 2893169 R 373384 CDS YP_690213.1 110806693 4208421 complement(2895286..2895696) 1 NC_008258.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 2895696 nrdI 4208421 nrdI Shigella flexneri 5 str. 8401 ribonucleotide reductase stimulatory protein YP_690213.1 2895286 R 373384 CDS YP_690214.1 110806694 4208422 complement(2895693..2895947) 1 NC_008258.1 Code: O; COG: COG0695; glutaredoxin-like protein 2895947 nrdH 4208422 nrdH Shigella flexneri 5 str. 8401 glutaredoxin-like protein YP_690214.1 2895693 R 373384 CDS YP_690215.1 110806695 4208423 complement(2896187..2896516) 1 NC_008258.1 Code: S; COG: COG4575; hypothetical protein 2896516 ygaM 4208423 ygaM Shigella flexneri 5 str. 8401 hypothetical protein YP_690215.1 2896187 R 373384 CDS YP_690216.1 110806696 4208424 2896668..2897012 1 NC_008258.1 hypothetical protein 2897012 ygaC 4208424 ygaC Shigella flexneri 5 str. 8401 hypothetical protein YP_690216.1 2896668 D 373384 CDS YP_690217.1 110806697 4208425 complement(2897049..2897498) 1 NC_008258.1 hypothetical protein 2897498 4208425 SFV_2833 Shigella flexneri 5 str. 8401 hypothetical protein YP_690217.1 2897049 R 373384 CDS YP_690218.1 110806698 4208426 2898168..2898572 1 NC_008258.1 Code: R; COG: COG2916; DNA binding protein, nucleoid-associated 2898572 stpA 4208426 stpA Shigella flexneri 5 str. 8401 DNA binding protein, nucleoid-associated YP_690218.1 2898168 D 373384 CDS YP_690219.1 110806699 4208427 complement(2898619..2899143) 1 NC_008258.1 Code: P; COG: COG0607; hypothetical protein 2899143 ygaP 4208427 ygaP Shigella flexneri 5 str. 8401 hypothetical protein YP_690219.1 2898619 R 373384 CDS YP_690220.1 110806700 4208428 complement(2899153..2899452) 1 NC_008258.1 Code: K; COG: COG0640; hypothetical protein 2899452 4208428 SFV_2836 Shigella flexneri 5 str. 8401 hypothetical protein YP_690220.1 2899153 R 373384 CDS YP_690221.1 110806701 4208429 2899635..2899793 1 NC_008258.1 Code: S; COG: COG0401; hypothetical protein 2899793 4208429 SFV_2837 Shigella flexneri 5 str. 8401 hypothetical protein YP_690221.1 2899635 D 373384 CDS YP_690222.1 110806702 4208430 2899877..2900326 1 NC_008258.1 Code: S; COG: COG1652; LysM domain/BON superfamily protein 2900326 ygaU 4208430 ygaU Shigella flexneri 5 str. 8401 LysM domain/BON superfamily protein YP_690222.1 2899877 D 373384 CDS YP_690223.1 110806703 4208431 complement(2900327..2900989) 1 NC_008258.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 2900989 ygaE 4208431 ygaE Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator CsiR YP_690223.1 2900327 R 373384 CDS YP_690224.1 110806704 4208432 complement(2901010..2902410) 1 NC_008258.1 Code: E; COG: COG1113; gamma-aminobutyrate transporter 2902410 gabP 4208432 gabP Shigella flexneri 5 str. 8401 gamma-aminobutyrate transporter YP_690224.1 2901010 R 373384 CDS YP_690225.1 110806705 4208433 complement(2902648..2903907) 1 NC_008258.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2903907 gabT 4208433 gabT Shigella flexneri 5 str. 8401 4-aminobutyrate aminotransferase YP_690225.1 2902648 R 373384 CDS YP_690226.1 110806706 4208435 complement(2905413..2906681) 1 NC_008258.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 2906681 ygaF 4208435 ygaF Shigella flexneri 5 str. 8401 hydroxyglutarate oxidase YP_690226.1 2905413 R 373384 CDS YP_690227.1 110806707 4208436 complement(2906701..2907783) 1 NC_008258.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2907783 4208436 SFV_2844 Shigella flexneri 5 str. 8401 hypothetical protein YP_690227.1 2906701 R 373384 CDS YP_690228.1 110806708 4208437 complement(2908014..2910266) 1 NC_008258.1 hypothetical protein 2910266 4208437 SFV_2845 Shigella flexneri 5 str. 8401 hypothetical protein YP_690228.1 2908014 R 373384 CDS YP_690229.1 110806709 4208439 complement(2911148..2912014) 1 NC_008258.1 Code: L; COG: COG2801; IS3 ORF2 2912014 4208439 SFV_2847 Shigella flexneri 5 str. 8401 IS3 ORF2 YP_690229.1 2911148 R 373384 CDS YP_690230.1 110806710 4208498 complement(2912011..2912310) 1 NC_008258.1 Code: L; COG: COG2963; IS3 ORF1 2912310 4208498 SFV_2848 Shigella flexneri 5 str. 8401 IS3 ORF1 YP_690230.1 2912011 R 373384 CDS YP_690231.1 110806711 4208499 complement(2912429..2912932) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2912932 insB 4208499 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690231.1 2912429 R 373384 CDS YP_690232.1 110806712 4208500 2913007..2913213 1 NC_008258.1 IS1 encoded protein 2913213 4208500 SFV_2850 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690232.1 2913007 D 373384 CDS YP_690233.1 110806713 4208501 complement(2913326..2914549) 1 NC_008258.1 CP4-57 prophage; integrase; integrase 2914549 intA 4208501 intA Shigella flexneri 5 str. 8401 integrase YP_690233.1 2913326 R 373384 CDS YP_690234.1 110806714 4208502 complement(2915331..2915813) 1 NC_008258.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2915813 smpB 4208502 smpB Shigella flexneri 5 str. 8401 SsrA-binding protein YP_690234.1 2915331 R 373384 CDS YP_690235.1 110806715 4208503 2916327..2916701 1 NC_008258.1 Code: S; COG: COG2914; hypothetical protein 2916701 4208503 SFV_2853 Shigella flexneri 5 str. 8401 hypothetical protein YP_690235.1 2916327 D 373384 CDS YP_690236.2 229774938 4208504 complement(2916763..2917104) 1 NC_008258.1 Code: J; COG: COG2913; hypothetical protein 2917104 smpA 4208504 smpA Shigella flexneri 5 str. 8401 hypothetical protein YP_690236.2 2916763 R 373384 CDS YP_690237.1 110806717 4208505 complement(2917253..2918914) 1 NC_008258.1 Code: L; COG: COG0497; recombination and repair protein 2918914 recN 4208505 recN Shigella flexneri 5 str. 8401 recombination and repair protein YP_690237.1 2917253 R 373384 CDS YP_690238.1 110806718 4208506 complement(2919000..2919878) 1 NC_008258.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2919878 ppnK 4208506 ppnK Shigella flexneri 5 str. 8401 inorganic polyphosphate/ATP-NAD kinase YP_690238.1 2919000 R 373384 CDS YP_690239.1 110806719 4208507 2920001..2920594 1 NC_008258.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2920594 grpE 4208507 grpE Shigella flexneri 5 str. 8401 heat shock protein GrpE YP_690239.1 2920001 D 373384 CDS YP_690240.1 110806720 4208508 complement(2920649..2921911) 1 NC_008258.1 Code: P; COG: COG4536; hypothetical protein 2921911 yfjD 4208508 yfjD Shigella flexneri 5 str. 8401 hypothetical protein YP_690240.1 2920649 R 373384 CDS YP_690241.1 110806721 4208509 complement(2921956..2922822) 1 NC_008258.1 Code: R; COG: COG4137; hypothetical protein 2922822 4208509 SFV_2859 Shigella flexneri 5 str. 8401 hypothetical protein YP_690241.1 2921956 R 373384 CDS YP_690242.1 110806722 4208510 2922914..2924275 1 NC_008258.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2924275 ffh 4208510 ffh Shigella flexneri 5 str. 8401 signal recognition particle protein YP_690242.1 2922914 D 373384 CDS YP_690243.1 110806723 4208511 2924352..2924660 1 NC_008258.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2924660 rpsP 4208511 rpsP Shigella flexneri 5 str. 8401 30S ribosomal protein S16 YP_690243.1 2924352 D 373384 CDS YP_690244.1 110806724 4208512 2924679..2925227 1 NC_008258.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2925227 rimM 4208512 rimM Shigella flexneri 5 str. 8401 16S rRNA-processing protein RimM YP_690244.1 2924679 D 373384 CDS YP_690245.1 110806725 4208513 2925258..2926025 1 NC_008258.1 tRNA (guanine-7-)-methyltransferase; methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2926025 trmD 4208513 trmD Shigella flexneri 5 str. 8401 tRNA (guanine-N(1)-)-methyltransferase YP_690245.1 2925258 D 373384 CDS YP_690246.1 110806726 4208514 2926067..2926414 1 NC_008258.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2926414 rplS 4208514 rplS Shigella flexneri 5 str. 8401 50S ribosomal protein L19 YP_690246.1 2926067 D 373384 CDS YP_690247.1 110806727 4208515 complement(2926491..2926973) 1 NC_008258.1 Code: M; COG: COG2885; outer membrane lipoprotein 2926973 yfiB 4208515 yfiB Shigella flexneri 5 str. 8401 outer membrane lipoprotein YP_690247.1 2926491 R 373384 CDS YP_690248.1 110806728 4208516 complement(2926989..2927675) 1 NC_008258.1 Code: T; COG: COG2199; hypothetical protein 2927675 yfiN 4208516 yfiN Shigella flexneri 5 str. 8401 hypothetical protein YP_690248.1 2926989 R 373384 CDS YP_690249.1 110806729 4210287 complement(2927855..2928211) 1 NC_008258.1 hypothetical protein 2928211 4210287 SFV_2867 Shigella flexneri 5 str. 8401 hypothetical protein YP_690249.1 2927855 R 373384 CDS YP_690250.1 110806730 4210288 complement(2928204..2928722) 1 NC_008258.1 hypothetical protein 2928722 4210288 SFV_2868 Shigella flexneri 5 str. 8401 hypothetical protein YP_690250.1 2928204 R 373384 CDS YP_690251.1 110806731 4210289 complement(2928872..2929237) 1 NC_008258.1 hypothetical protein 2929237 yfiL 4210289 yfiL Shigella flexneri 5 str. 8401 hypothetical protein YP_690251.1 2928872 R 373384 CDS YP_690252.1 110806732 4210290 2929447..2930517 1 NC_008258.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2930517 aroF 4210290 aroF Shigella flexneri 5 str. 8401 phospho-2-dehydro-3-deoxyheptonate aldolase YP_690252.1 2929447 D 373384 CDS YP_690253.1 110806733 4210291 2930528..2931649 1 NC_008258.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2931649 tyrA 4210291 tyrA Shigella flexneri 5 str. 8401 bifunctional chorismate mutase/prephenate dehydrogenase YP_690253.1 2930528 D 373384 CDS YP_690254.1 110806734 4210292 complement(2931692..2932852) 1 NC_008258.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2932852 pheA 4210292 pheA Shigella flexneri 5 str. 8401 bifunctional chorismate mutase/prephenate dehydratase YP_690254.1 2931692 R 373384 CDS YP_690255.1 110806735 4210293 complement(2933102..2933443) 1 NC_008258.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2933443 yfiA 4210293 yfiA Shigella flexneri 5 str. 8401 translation inhibitor protein RaiA YP_690255.1 2933102 R 373384 CDS YP_690256.1 110806736 4210294 2933757..2935103 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 2935103 4210294 SFV_2874 Shigella flexneri 5 str. 8401 IS4 orf YP_690256.1 2933757 D 373384 CDS YP_690257.1 110806737 4210295 2935667..2936956 1 NC_008258.1 Code: E; COG: COG0814; serine transporter 2936956 sdaC 4210295 sdaC Shigella flexneri 5 str. 8401 serine transporter YP_690257.1 2935667 D 373384 CDS YP_690258.1 110806738 4210296 2937014..2938381 1 NC_008258.1 Code: E; COG: COG1760; L-serine dehydratase 2938381 sdaB 4210296 sdaB Shigella flexneri 5 str. 8401 L-serine dehydratase YP_690258.1 2937014 D 373384 CDS YP_690259.1 110806739 4210297 2938402..2939247 1 NC_008258.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 2939247 xni 4210297 xni Shigella flexneri 5 str. 8401 exonuclease IX YP_690259.1 2938402 D 373384 CDS YP_690260.1 110806740 4210298 complement(2939300..2940448) 1 NC_008258.1 Code: C; COG: COG1454; L-1,2-propanediol oxidoreductase 2940448 fucO 4210298 fucO Shigella flexneri 5 str. 8401 L-1,2-propanediol oxidoreductase YP_690260.1 2939300 R 373384 CDS YP_690261.1 110806741 4210299 complement(2940476..2941123) 1 NC_008258.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 2941123 fucA 4210299 fucA Shigella flexneri 5 str. 8401 L-fuculose phosphate aldolase YP_690261.1 2940476 R 373384 CDS YP_690262.1 110806742 4210300 2941670..2942986 1 NC_008258.1 Code: G; COG: COG0738; L-fucose transporter 2942986 fucP 4210300 fucP Shigella flexneri 5 str. 8401 L-fucose transporter YP_690262.1 2941670 D 373384 CDS YP_690263.1 110806743 4210301 2943019..2944794 1 NC_008258.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2944794 fucI 4210301 fucI Shigella flexneri 5 str. 8401 L-fucose isomerase YP_690263.1 2943019 D 373384 CDS YP_690264.1 110806744 4210303 2946324..2946746 1 NC_008258.1 Code: G; COG: COG4154; protein of fucose operon 2946746 fucU 4210303 fucU Shigella flexneri 5 str. 8401 protein of fucose operon YP_690264.1 2946324 D 373384 CDS YP_690265.1 110806745 4210304 2946804..2947535 1 NC_008258.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 2947535 fucR 4210304 fucR Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator FucR YP_690265.1 2946804 D 373384 CDS YP_690266.1 110806746 4210305 complement(2947579..2948679) 1 NC_008258.1 Code: R; COG: COG2933; RNA 2'-O-ribose methyltransferase 2948679 ygdE 4210305 ygdE Shigella flexneri 5 str. 8401 RNA 2'-O-ribose methyltransferase YP_690266.1 2947579 R 373384 CDS YP_690267.1 110806747 4210306 complement(2948672..2949067) 1 NC_008258.1 Code: S; COG: COG2363; hypothetical protein 2949067 ygdD 4210306 ygdD Shigella flexneri 5 str. 8401 hypothetical protein YP_690267.1 2948672 R 373384 CDS YP_690268.1 110806748 4209252 complement(2949086..2950003) 1 NC_008258.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 2950003 gcvA 4209252 gcvA Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator GcvA YP_690268.1 2949086 R 373384 CDS YP_690269.1 110806749 4209253 complement(2950354..2950581) 1 NC_008258.1 hypothetical protein 2950581 4209253 SFV_2888 Shigella flexneri 5 str. 8401 hypothetical protein YP_690269.1 2950354 R 373384 CDS YP_690270.1 110806750 4209254 2950773..2951978 1 NC_008258.1 Code: E; COG: COG0520; cysteine sulfinate desulfinase 2951978 4209254 SFV_2889 Shigella flexneri 5 str. 8401 cysteine sulfinate desulfinase YP_690270.1 2950773 D 373384 CDS YP_690271.1 110806751 4209255 2951978..2952421 1 NC_008258.1 Code: R; COG: COG2166; hypothetical protein 2952421 ygdK 4209255 ygdK Shigella flexneri 5 str. 8401 hypothetical protein YP_690271.1 2951978 D 373384 CDS YP_690272.1 110806752 4209256 complement(2952472..2953278) 1 NC_008258.1 Code: H; COG: COG1179; hypothetical protein 2953278 ygdL 4209256 ygdL Shigella flexneri 5 str. 8401 hypothetical protein YP_690272.1 2952472 R 373384 CDS YP_690273.1 110806753 4209257 complement(2953517..2954614) 1 NC_008258.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 2954614 mltA 4209257 mltA Shigella flexneri 5 str. 8401 murein transglycosylase A YP_690273.1 2953517 R 373384 CDS YP_690274.1 110806754 4209260 complement(2955084..2956337) 1 NC_008258.1 Code: M; COG: COG0860; amidase 2956337 4209260 SFV_2895 Shigella flexneri 5 str. 8401 amidase YP_690274.1 2955084 R 373384 CDS YP_690275.1 110806755 4209261 2956569..2957900 1 NC_008258.1 amino acid acetyltransferase; catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 2957900 argA 4209261 argA Shigella flexneri 5 str. 8401 N-acetylglutamate synthase YP_690275.1 2956569 D 373384 CDS YP_690276.1 110806756 4209262 complement(2957962..2959788) 1 NC_008258.1 DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 2959788 recD 4209262 recD Shigella flexneri 5 str. 8401 exonuclease V subunit alpha YP_690276.1 2957962 R 373384 CDS YP_690277.1 110806757 4209263 complement(2959788..2963330) 1 NC_008258.1 DNA helicase; , ssDNA endonuclease; helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 2963330 recB 4209263 recB Shigella flexneri 5 str. 8401 exonuclease V subunit beta YP_690277.1 2959788 R 373384 CDS YP_690278.1 110806758 4209264 complement(2963323..2966211) 1 NC_008258.1 Code: O; COG: COG1025; protease III 2966211 ptr 4209264 ptr Shigella flexneri 5 str. 8401 protease III YP_690278.1 2963323 R 373384 CDS YP_690279.1 110806759 4209265 complement(2966387..2969755) 1 NC_008258.1 DNA helicase; ssDNA endonuclease; catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 2969755 recC 4209265 recC Shigella flexneri 5 str. 8401 exonuclease V subunit gamma YP_690279.1 2966387 R 373384 CDS YP_690280.1 110806760 4209266 complement(2969768..2970091) 1 NC_008258.1 Code: NU; COG: COG4967; hypothetical protein 2970091 ppdC 4209266 ppdC Shigella flexneri 5 str. 8401 hypothetical protein YP_690280.1 2969768 R 373384 CDS YP_690281.1 110806761 4209267 complement(2970076..2970483) 1 NC_008258.1 hypothetical protein 2970483 ygdB 4209267 ygdB Shigella flexneri 5 str. 8401 hypothetical protein YP_690281.1 2970076 R 373384 CDS YP_690282.1 110806762 4209268 complement(2970480..2971043) 1 NC_008258.1 Code: U; COG: COG4795; hypothetical protein 2971043 ppdB 4209268 ppdB Shigella flexneri 5 str. 8401 hypothetical protein YP_690282.1 2970480 R 373384 CDS YP_690283.1 110806763 4207209 complement(2971688..2972482) 1 NC_008258.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 2972482 thyA 4207209 thyA Shigella flexneri 5 str. 8401 thymidylate synthase YP_690283.1 2971688 R 373384 CDS YP_690284.1 110806764 4207210 complement(2972489..2973304) 1 NC_008258.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 2973304 lgt 4207210 lgt Shigella flexneri 5 str. 8401 prolipoprotein diacylglyceryl transferase YP_690284.1 2972489 R 373384 CDS YP_690285.1 110806765 4207211 complement(2973515..2975761) 1 NC_008258.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 2975761 ptsP 4207211 ptsP Shigella flexneri 5 str. 8401 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_690285.1 2973515 R 373384 CDS YP_690286.1 110806766 4207212 complement(2975774..2976304) 1 NC_008258.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 2976304 ygdP 4207212 ygdP Shigella flexneri 5 str. 8401 dinucleoside polyphosphate hydrolase YP_690286.1 2975774 R 373384 CDS YP_690287.1 110806767 4207213 2976989..2977678 1 NC_008258.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 2977678 mutH 4207213 mutH Shigella flexneri 5 str. 8401 DNA mismatch repair protein YP_690287.1 2976989 D 373384 CDS YP_690288.1 110806768 4207214 2977747..2978460 1 NC_008258.1 Code: P; COG: COG0861; transport protein 2978460 4207214 SFV_2910 Shigella flexneri 5 str. 8401 transport protein YP_690288.1 2977747 D 373384 CDS YP_690289.1 110806769 4207215 2978598..2978816 1 NC_008258.1 hypothetical protein 2978816 4207215 SFV_2911 Shigella flexneri 5 str. 8401 hypothetical protein YP_690289.1 2978598 D 373384 CDS YP_690290.1 110806770 4207216 2978924..2979964 1 NC_008258.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 2979964 tas 4207216 tas Shigella flexneri 5 str. 8401 aldo-keto reductase YP_690290.1 2978924 D 373384 CDS YP_690291.1 110806771 4207217 complement(2979997..2981142) 1 NC_008258.1 Code: GEPR; COG: COG0477; lysophospholipid transporter LplT 2981142 ygeD 4207217 ygeD Shigella flexneri 5 str. 8401 lysophospholipid transporter LplT YP_690291.1 2979997 R 373384 CDS YP_690292.1 110806772 4207218 complement(2981180..2983339) 1 NC_008258.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 2983339 aas 4207218 aas Shigella flexneri 5 str. 8401 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_690292.1 2981180 R 373384 CDS YP_690293.1 110806773 4207219 2983925..2984956 1 NC_008258.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 2984956 galR 4207219 galR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator GalR YP_690293.1 2983925 D 373384 CDS YP_690294.1 110806774 4207220 complement(2984963..2986225) 1 NC_008258.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 2986225 lysA 4207220 lysA Shigella flexneri 5 str. 8401 diaminopimelate decarboxylase YP_690294.1 2984963 R 373384 CDS YP_690295.1 110806775 4207221 2986347..2987282 1 NC_008258.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; LysR family transcriptional regulator 2987282 lysR 4207221 lysR Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_690295.1 2986347 D 373384 CDS YP_690296.1 110806776 4207222 complement(2987269..2988282) 1 NC_008258.1 Code: M; COG: COG1794; resistance proteins 2988282 ygeA 4207222 ygeA Shigella flexneri 5 str. 8401 resistance proteins YP_690296.1 2987269 R 373384 CDS YP_690297.1 110806777 4207223 complement(2988292..2989635) 1 NC_008258.1 Code: GEPR; COG: COG0477; low-affinity L-arabinose transport system proton symport protein 2989635 araE 4207223 araE Shigella flexneri 5 str. 8401 low-affinity L-arabinose transport system proton symport protein YP_690297.1 2988292 R 373384 CDS YP_690298.1 110806778 4207224 complement(2989821..2990582) 1 NC_008258.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 2990582 kduD 4207224 kduD Shigella flexneri 5 str. 8401 2-deoxy-D-gluconate 3-dehydrogenase YP_690298.1 2989821 R 373384 CDS YP_690299.1 110806779 4207225 complement(2990612..2991448) 1 NC_008258.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 2991448 kduI 4207225 kduI Shigella flexneri 5 str. 8401 5-keto-4-deoxyuronate isomerase YP_690299.1 2990612 R 373384 CDS YP_690300.1 110806780 4207226 complement(2991735..2992916) 1 NC_008258.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 2992916 yqeF 4207226 yqeF Shigella flexneri 5 str. 8401 acetyl-CoA acetyltransferase YP_690300.1 2991735 R 373384 CDS YP_690301.1 110806781 4209155 2995030..2995329 1 NC_008258.1 Code: L; COG: COG2963; IS3 ORF1 2995329 4209155 SFV_2924 Shigella flexneri 5 str. 8401 IS3 ORF1 YP_690301.1 2995030 D 373384 CDS YP_690302.1 110806782 4209156 2995326..2996192 1 NC_008258.1 Code: L; COG: COG2801; IS3 ORF2 2996192 4209156 SFV_2925 Shigella flexneri 5 str. 8401 IS3 ORF2 YP_690302.1 2995326 D 373384 CDS YP_690303.1 110806783 4209157 complement(2996206..2996799) 1 NC_008258.1 hypothetical protein 2996799 4209157 SFV_2926 Shigella flexneri 5 str. 8401 hypothetical protein YP_690303.1 2996206 R 373384 CDS YP_690304.1 110806784 4209159 complement(2997143..2997898) 1 NC_008258.1 Code: M; COG: COG0739; lipoprotein 2997898 4209159 SFV_2928 Shigella flexneri 5 str. 8401 lipoprotein YP_690304.1 2997143 R 373384 CDS YP_690305.1 110806785 4209160 complement(2997932..2998189) 1 NC_008258.1 IS1 encoded protein 2998189 4209160 SFV_2929 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690305.1 2997932 R 373384 CDS YP_690306.1 110806786 4209161 2998264..2998767 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 2998767 insB 4209161 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690306.1 2998264 D 373384 CDS YP_690307.1 110806787 4209162 2999090..3001387 1 NC_008258.1 molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3001387 4209162 SFV_2931 Shigella flexneri 5 str. 8401 xanthine dehydrogenase subunit XdhA YP_690307.1 2999090 D 373384 CDS YP_690308.1 110806788 4209163 3001398..3002276 1 NC_008258.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3002276 ygeT 4209163 ygeT Shigella flexneri 5 str. 8401 xanthine dehydrogenase subunit XdhB YP_690308.1 3001398 D 373384 CDS YP_690309.1 110806789 4209164 3002273..3002752 1 NC_008258.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3002752 4209164 SFV_2933 Shigella flexneri 5 str. 8401 xanthine dehydrogenase subunit XdhC YP_690309.1 3002273 D 373384 CDS YP_690310.1 110806790 4209165 complement(3002772..3002984) 1 NC_008258.1 IS1 encoded protein 3002984 4209165 SFV_2934 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690310.1 3002772 R 373384 CDS YP_690311.1 110806791 4209166 3003059..3003562 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3003562 insB 4209166 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690311.1 3003059 D 373384 CDS YP_690312.1 110806792 4209167 3003887..3005335 1 NC_008258.1 Code: F; COG: COG2233; permease 3005335 ygfU 4209167 ygfU Shigella flexneri 5 str. 8401 permease YP_690312.1 3003887 D 373384 CDS YP_690313.1 110806793 4209168 3005585..3006133 1 NC_008258.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3006133 4209168 SFV_2937 Shigella flexneri 5 str. 8401 isopentenyl-diphosphate delta-isomerase YP_690313.1 3005585 D 373384 CDS YP_690314.1 110806794 4209169 complement(3006176..3007693) 1 NC_008258.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3007693 lysS 4209169 lysS Shigella flexneri 5 str. 8401 lysyl-tRNA synthetase YP_690314.1 3006176 R 373384 CDS YP_690315.1 110806795 4209171 complement(3008892..3010484) 1 NC_008258.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3010484 recJ 4209171 recJ Shigella flexneri 5 str. 8401 ssDNA exonuclease RecJ YP_690315.1 3008892 R 373384 CDS YP_690316.1 110806796 4209172 complement(3010631..3011341) 1 NC_008258.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3011341 dsbC 4209172 dsbC Shigella flexneri 5 str. 8401 thiol:disulfide interchange protein DsbC YP_690316.1 3010631 R 373384 CDS YP_690317.1 110806797 4208707 complement(3011366..3012262) 1 NC_008258.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3012262 xerD 4208707 xerD Shigella flexneri 5 str. 8401 site-specific tyrosine recombinase XerD YP_690317.1 3011366 R 373384 CDS YP_690318.1 110806798 4208708 3012374..3012895 1 NC_008258.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3012895 fldB 4208708 fldB Shigella flexneri 5 str. 8401 flavodoxin FldB YP_690318.1 3012374 D 373384 CDS YP_690319.1 110806799 4208709 complement(3012935..3013342) 1 NC_008258.1 hypothetical protein 3013342 4208709 SFV_2944 Shigella flexneri 5 str. 8401 hypothetical protein YP_690319.1 3012935 R 373384 CDS YP_690320.1 110806800 4208710 complement(3013323..3013589) 1 NC_008258.1 Code: S; COG: COG2938; hypothetical protein 3013589 ygfY 4208710 ygfY Shigella flexneri 5 str. 8401 hypothetical protein YP_690320.1 3013323 R 373384 CDS YP_690321.1 110806801 4208711 3013832..3014812 1 NC_008258.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3014812 ygfZ 4208711 ygfZ Shigella flexneri 5 str. 8401 global regulator YP_690321.1 3013832 D 373384 CDS YP_690322.1 110806802 4208712 complement(3015008..3015667) 1 NC_008258.1 Code: R; COG: COG1272; oxidoreductase 3015667 4208712 SFV_2947 Shigella flexneri 5 str. 8401 oxidoreductase YP_690322.1 3015008 R 373384 CDS YP_690323.1 110806803 4208713 complement(3015831..3016031) 1 NC_008258.1 Code: S; COG: COG3097; hypothetical protein 3016031 4208713 SFV_2948 Shigella flexneri 5 str. 8401 hypothetical protein YP_690323.1 3015831 R 373384 CDS YP_690324.1 110806804 4208714 3016180..3017520 1 NC_008258.1 Code: G; COG: COG2723; 6-phospho-beta-glucosidase 3017520 bglA 4208714 bglA Shigella flexneri 5 str. 8401 6-phospho-beta-glucosidase YP_690324.1 3016180 D 373384 CDS YP_690325.1 110806805 4208716 complement(3018685..3021558) 1 NC_008258.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3021558 gcvP 4208716 gcvP Shigella flexneri 5 str. 8401 glycine dehydrogenase YP_690325.1 3018685 R 373384 CDS YP_690326.1 110806806 4208717 complement(3021677..3022066) 1 NC_008258.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3022066 gcvH 4208717 gcvH Shigella flexneri 5 str. 8401 glycine cleavage system protein H YP_690326.1 3021677 R 373384 CDS YP_690327.1 110806807 4208718 complement(3022090..3023184) 1 NC_008258.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3023184 gcvT 4208718 gcvT Shigella flexneri 5 str. 8401 glycine cleavage system aminomethyltransferase T YP_690327.1 3022090 R 373384 CDS YP_690328.1 110806808 4208719 complement(3023632..3024834) 1 NC_008258.1 Code: HC; COG: COG0654; hypothetical protein 3024834 visC 4208719 visC Shigella flexneri 5 str. 8401 hypothetical protein YP_690328.1 3023632 R 373384 CDS YP_690329.1 110806809 4208720 complement(3024857..3026035) 1 NC_008258.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3026035 ubiH 4208720 ubiH Shigella flexneri 5 str. 8401 2-octaprenyl-6-methoxyphenyl hydroxylase YP_690329.1 3024857 R 373384 CDS YP_690330.1 110806810 4208721 complement(3026032..3027357) 1 NC_008258.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3027357 pepP 4208721 pepP Shigella flexneri 5 str. 8401 proline aminopeptidase P II YP_690330.1 3026032 R 373384 CDS YP_690331.1 110806811 4208722 complement(3027383..3027967) 1 NC_008258.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3027967 ygfB 4208722 ygfB Shigella flexneri 5 str. 8401 hypothetical protein YP_690331.1 3027383 R 373384 CDS YP_690332.1 110806812 4208723 3028129..3028458 1 NC_008258.1 Code: S; COG: COG3027; Z-ring-associated protein 3028458 ygfE 4208723 ygfE Shigella flexneri 5 str. 8401 Z-ring-associated protein YP_690332.1 3028129 D 373384 CDS YP_690333.2 229774937 4208724 3028758..3029306 1 NC_008258.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3029306 ygfA 4208724 ygfA Shigella flexneri 5 str. 8401 ligase YP_690333.2 3028758 D 373384 CDS YP_690334.1 110806814 4208725 complement(3030087..3031319) 1 NC_008258.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3031319 serA 4208725 serA Shigella flexneri 5 str. 8401 D-3-phosphoglycerate dehydrogenase YP_690334.1 3030087 R 373384 CDS YP_690335.1 110806815 4208726 complement(3031575..3032234) 1 NC_008258.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3032234 rpiA 4208726 rpiA Shigella flexneri 5 str. 8401 ribose-5-phosphate isomerase A YP_690335.1 3031575 R 373384 CDS YP_690336.1 110806816 4209288 3032617..3033510 1 NC_008258.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3033510 iciA 4209288 iciA Shigella flexneri 5 str. 8401 chromosome replication initiation inhibitor protein YP_690336.1 3032617 D 373384 CDS YP_690337.1 110806817 4209289 3033714..3035858 1 NC_008258.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 3035858 sbm 4209289 sbm Shigella flexneri 5 str. 8401 methylmalonyl-CoA mutase YP_690337.1 3033714 D 373384 CDS YP_690338.1 110806818 4209290 3035851..3036846 1 NC_008258.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3036846 ygfD 4209290 ygfD Shigella flexneri 5 str. 8401 arginine/ornithine transport system ATPase YP_690338.1 3035851 D 373384 CDS YP_690339.1 110806819 4209291 3036857..3037642 1 NC_008258.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3037642 ygfG 4209291 ygfG Shigella flexneri 5 str. 8401 methylmalonyl-CoA decarboxylase YP_690339.1 3036857 D 373384 CDS YP_690340.1 110806820 4209292 3037666..3039144 1 NC_008258.1 Code: C; COG: COG0427; coenzyme A transferase 3039144 ygfH 4209292 ygfH Shigella flexneri 5 str. 8401 coenzyme A transferase YP_690340.1 3037666 D 373384 CDS YP_690341.1 110806821 4209293 complement(3039614..3040036) 1 NC_008258.1 LysR family transcriptional regulator 3040036 4209293 SFV_2967 Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_690341.1 3039614 R 373384 CDS YP_690342.1 110806822 4209294 complement(3040203..3040910) 1 NC_008258.1 Code: S; COG: COG2968; hypothetical protein 3040910 yggE 4209294 yggE Shigella flexneri 5 str. 8401 hypothetical protein YP_690342.1 3040203 R 373384 CDS YP_690343.1 110806823 4209295 complement(3041036..3041629) 1 NC_008258.1 Involved in the export of arginine; arginine exporter protein 3041629 yggA 4209295 yggA Shigella flexneri 5 str. 8401 arginine exporter protein YP_690343.1 3041036 R 373384 CDS YP_690344.1 110806824 4209296 complement(3041810..3042670) 1 NC_008258.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive ion channel MscS 3042670 yggB 4209296 yggB Shigella flexneri 5 str. 8401 mechanosensitive ion channel MscS YP_690344.1 3041810 R 373384 CDS YP_690345.2 229774936 4209297 complement(3042861..3043940) 1 NC_008258.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3043940 fba 4209297 fba Shigella flexneri 5 str. 8401 fructose-bisphosphate aldolase YP_690345.2 3042861 R 373384 CDS YP_690346.1 110806826 4209298 complement(3044155..3045318) 1 NC_008258.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3045318 pgk 4209298 pgk Shigella flexneri 5 str. 8401 phosphoglycerate kinase YP_690346.1 3044155 R 373384 CDS YP_690347.1 110806827 4209299 complement(3045368..3046387) 1 NC_008258.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3046387 epd 4209299 epd Shigella flexneri 5 str. 8401 erythrose 4-phosphate dehydrogenase YP_690347.1 3045368 R 373384 CDS YP_690348.1 110806828 4209300 3046759..3047190 1 NC_008258.1 Code: R; COG: COG1661; hypothetical protein 3047190 4209300 SFV_2974 Shigella flexneri 5 str. 8401 hypothetical protein YP_690348.1 3046759 D 373384 CDS YP_690349.1 110806829 4209301 3047213..3047791 1 NC_008258.1 inner membrane protein 3047791 4209301 SFV_2975 Shigella flexneri 5 str. 8401 inner membrane protein YP_690349.1 3047213 D 373384 CDS YP_690350.1 110806830 4209302 3047792..3048100 1 NC_008258.1 lipoprotein 3048100 4209302 SFV_2976 Shigella flexneri 5 str. 8401 lipoprotein YP_690350.1 3047792 D 373384 CDS YP_690351.1 110806831 4209303 3048101..3048499 1 NC_008258.1 lipoprotein 3048499 4209303 SFV_2977 Shigella flexneri 5 str. 8401 lipoprotein YP_690351.1 3048101 D 373384 CDS YP_690352.1 110806832 4209304 3048487..3049164 1 NC_008258.1 Code: P; COG: COG1122; ABC transporter ATP-binding protein 3049164 4209304 SFV_2978 Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_690352.1 3048487 D 373384 CDS YP_690353.1 110806833 4209305 3049302..3049835 1 NC_008258.1 Code: P; COG: COG1118; ABC transporter ATP-binding protein 3049835 4209305 SFV_2979 Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_690353.1 3049302 D 373384 CDS YP_690354.1 110806834 4209306 complement(3049807..3050520) 1 NC_008258.1 Code: H; COG: COG1072; fructose transport system kinase 3050520 frcK 4209306 frcK Shigella flexneri 5 str. 8401 fructose transport system kinase YP_690354.1 3049807 R 373384 CDS YP_690355.1 110806835 4210113 complement(3050517..3051026) 1 NC_008258.1 Code: K; COG: COG3722; DNA-binding transcriptional regulator 3051026 yggD 4210113 yggD Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_690355.1 3050517 R 373384 CDS YP_690356.1 110806836 4210114 complement(3051048..3052013) 1 NC_008258.1 Code: G; COG: COG1494; fructose-1,6-bisphosphatase II-like protein 3052013 yggF 4210114 yggF Shigella flexneri 5 str. 8401 fructose-1,6-bisphosphatase II-like protein YP_690356.1 3051048 R 373384 CDS YP_690357.1 110806837 4210115 complement(3052010..3053251) 1 NC_008258.1 Code: ER; COG: COG1063; oxidoreductase 3053251 4210115 SFV_2983 Shigella flexneri 5 str. 8401 oxidoreductase YP_690357.1 3052010 R 373384 CDS YP_690358.1 110806838 4210116 complement(3053253..3053756) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3053756 insB 4210116 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690358.1 3053253 R 373384 CDS YP_690359.1 110806839 4210117 3053831..3054049 1 NC_008258.1 IS1 encoded protein 3054049 4210117 SFV_2985 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690359.1 3053831 D 373384 CDS YP_690360.1 110806840 4210118 3054313..3055221 1 NC_008258.1 Code: O; COG: COG0330; serine protease 3055221 4210118 SFV_2986 Shigella flexneri 5 str. 8401 serine protease YP_690360.1 3054313 D 373384 CDS YP_690361.1 110806841 4210119 complement(3055267..3057258) 1 NC_008258.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3057258 tktA 4210119 tktA Shigella flexneri 5 str. 8401 transketolase YP_690361.1 3055267 R 373384 CDS YP_690362.1 110806842 4210120 3057317..3058294 1 NC_008258.1 Code: O; COG: COG0501; hypothetical protein 3058294 yggG 4210120 yggG Shigella flexneri 5 str. 8401 hypothetical protein YP_690362.1 3057317 D 373384 CDS YP_690363.1 110806843 4210121 complement(3058495..3059415) 1 NC_008258.1 catalyzes the formation of putrescine from agmatine; agmatinase 3059415 speB 4210121 speB Shigella flexneri 5 str. 8401 agmatinase YP_690363.1 3058495 R 373384 CDS YP_690364.1 110806844 4210122 complement(3059551..3059925) 1 NC_008258.1 lipoprotein 3059925 4210122 SFV_2990 Shigella flexneri 5 str. 8401 lipoprotein YP_690364.1 3059551 R 373384 CDS YP_690365.1 110806845 4210123 complement(3059951..3060454) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3060454 insB 4210123 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690365.1 3059951 R 373384 CDS YP_690366.1 110806846 4210124 3060529..3060717 1 NC_008258.1 IS1 encoded protein 3060717 4210124 SFV_2992 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690366.1 3060529 D 373384 CDS YP_690367.1 110806847 4210125 complement(3060795..3062693) 1 NC_008258.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3062693 speA 4210125 speA Shigella flexneri 5 str. 8401 arginine decarboxylase YP_690367.1 3060795 R 373384 CDS YP_690368.1 110806848 4210126 complement(3062780..3062926) 1 NC_008258.1 hypothetical protein 3062926 yqgB 4210126 yqgB Shigella flexneri 5 str. 8401 hypothetical protein YP_690368.1 3062780 R 373384 CDS YP_690369.1 110806849 4210127 complement(3063259..3063510) 1 NC_008258.1 hypothetical protein 3063510 yqgD 4210127 yqgD Shigella flexneri 5 str. 8401 hypothetical protein YP_690369.1 3063259 R 373384 CDS YP_690370.1 110806850 4210128 3063566..3064720 1 NC_008258.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3064720 metK 4210128 metK Shigella flexneri 5 str. 8401 S-adenosylmethionine synthetase YP_690370.1 3063566 D 373384 CDS YP_690371.1 110806851 4210129 3065155..3066549 1 NC_008258.1 Code: GEPR; COG: COG0477; galactose:proton symporter, MFS family 3066549 galP 4210129 galP Shigella flexneri 5 str. 8401 galactose:proton symporter, MFS family YP_690371.1 3065155 D 373384 CDS YP_690372.1 110806852 4210130 3066626..3067123 1 NC_008258.1 Code: S; COG: COG3091; hypothetical protein 3067123 sprT 4210130 sprT Shigella flexneri 5 str. 8401 hypothetical protein YP_690372.1 3066626 D 373384 CDS YP_690373.1 110806853 4210131 3067218..3067925 1 NC_008258.1 Code: L; COG: COG2356; DNA-specific endonuclease I 3067925 endA 4210131 endA Shigella flexneri 5 str. 8401 DNA-specific endonuclease I YP_690373.1 3067218 D 373384 CDS YP_690374.1 110806854 4210132 3068005..3068736 1 NC_008258.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3068736 yggJ 4210132 yggJ Shigella flexneri 5 str. 8401 16S ribosomal RNA methyltransferase RsmE YP_690374.1 3068005 D 373384 CDS YP_690375.1 110806855 4210748 3068749..3069699 1 NC_008258.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3069699 gshB 4210748 gshB Shigella flexneri 5 str. 8401 glutathione synthetase YP_690375.1 3068749 D 373384 CDS YP_690376.1 110806856 4210749 3069736..3070371 1 NC_008258.1 Code: K; COG: COG1678; hypothetical protein 3070371 yqgE 4210749 yqgE Shigella flexneri 5 str. 8401 hypothetical protein YP_690376.1 3069736 D 373384 CDS YP_690377.1 110806857 4210750 3070371..3070787 1 NC_008258.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3070787 yqgF 4210750 yqgF Shigella flexneri 5 str. 8401 Holliday junction resolvase-like protein YP_690377.1 3070371 D 373384 CDS YP_690378.1 110806858 4210751 complement(3070963..3071943) 1 NC_008258.1 Code: NU; COG: COG2805; transport protein 3071943 yggR 4210751 yggR Shigella flexneri 5 str. 8401 transport protein YP_690378.1 3070963 R 373384 CDS YP_690379.1 110806859 4210752 3071961..3072665 1 NC_008258.1 Code: R; COG: COG0325; hypothetical protein 3072665 yggS 4210752 yggS Shigella flexneri 5 str. 8401 hypothetical protein YP_690379.1 3071961 D 373384 CDS YP_690380.1 110806860 4210753 3072683..3073249 1 NC_008258.1 Code: S; COG: COG0762; resistance protein 3073249 yggT 4210753 yggT Shigella flexneri 5 str. 8401 resistance protein YP_690380.1 3072683 D 373384 CDS YP_690381.1 110806861 4210754 3073234..3073536 1 NC_008258.1 Code: S; COG: COG1872; hypothetical protein 3073536 yggU 4210754 yggU Shigella flexneri 5 str. 8401 hypothetical protein YP_690381.1 3073234 D 373384 CDS YP_690382.1 110806862 4210755 3073544..3074137 1 NC_008258.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3074137 yggV 4210755 yggV Shigella flexneri 5 str. 8401 deoxyribonucleotide triphosphate pyrophosphatase YP_690382.1 3073544 D 373384 CDS YP_690383.1 110806863 4210756 3074130..3075266 1 NC_008258.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3075266 yggW 4210756 yggW Shigella flexneri 5 str. 8401 coproporphyrinogen III oxidase YP_690383.1 3074130 D 373384 CDS YP_690384.1 110806864 4210757 3075580..3075933 1 NC_008258.1 hypothetical protein 3075933 4210757 SFV_3010 Shigella flexneri 5 str. 8401 hypothetical protein YP_690384.1 3075580 D 373384 CDS YP_690385.1 110806865 4210758 3075950..3076543 1 NC_008258.1 hypothetical protein 3076543 4210758 SFV_3011 Shigella flexneri 5 str. 8401 hypothetical protein YP_690385.1 3075950 D 373384 CDS YP_690386.1 110806866 4210759 3076588..3077091 1 NC_008258.1 Code: G; COG: COG3090; hypothetical protein 3077091 4210759 SFV_3012 Shigella flexneri 5 str. 8401 hypothetical protein YP_690386.1 3076588 D 373384 CDS YP_690387.1 110806867 4210760 3077091..3078392 1 NC_008258.1 Code: G; COG: COG1593; hypothetical protein 3078392 4210760 SFV_3013 Shigella flexneri 5 str. 8401 hypothetical protein YP_690387.1 3077091 D 373384 CDS YP_690388.1 110806868 4210761 complement(3078448..3079419) 1 NC_008258.1 alpha helix chain 3079419 yggM 4210761 yggM Shigella flexneri 5 str. 8401 alpha helix chain YP_690388.1 3078448 R 373384 CDS YP_690389.1 110806869 4210762 complement(3079572..3080618) 1 NC_008258.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3080618 ansB 4210762 ansB Shigella flexneri 5 str. 8401 L-asparaginase II YP_690389.1 3079572 R 373384 CDS YP_690390.1 110806870 4210763 complement(3080794..3081510) 1 NC_008258.1 hypothetical protein 3081510 yggN 4210763 yggN Shigella flexneri 5 str. 8401 hypothetical protein YP_690390.1 3080794 R 373384 CDS YP_690391.1 110806871 4210764 complement(3081697..3082023) 1 NC_008258.1 Code: S; COG: COG3171; hypothetical protein 3082023 yggL 4210764 yggL Shigella flexneri 5 str. 8401 hypothetical protein YP_690391.1 3081697 R 373384 CDS YP_690392.1 110806872 4210765 complement(3082023..3082742) 1 NC_008258.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3082742 trmB 4210765 trmB Shigella flexneri 5 str. 8401 tRNA (guanine-N(7)-)-methyltransferase YP_690392.1 3082023 R 373384 CDS YP_690393.1 110806873 4210766 3082873..3083955 1 NC_008258.1 Code: L; COG: COG1194; adenine DNA glycosylase 3083955 mutY 4210766 mutY Shigella flexneri 5 str. 8401 adenine DNA glycosylase YP_690393.1 3082873 D 373384 CDS YP_690394.1 110806875 4210861 complement(3083932..3084225) 1 NC_008258.1 hypothetical protein 3084225 4210861 SFV_3021 Shigella flexneri 5 str. 8401 hypothetical protein YP_690394.1 3083932 R 373384 CDS YP_690395.1 110806874 4210860 3083983..3084258 1 NC_008258.1 Code: CO; COG: COG2924; hypothetical protein 3084258 yggX 4210860 yggX Shigella flexneri 5 str. 8401 hypothetical protein YP_690395.1 3083983 D 373384 CDS YP_690396.1 110806876 4210862 3084320..3085402 1 NC_008258.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3085402 mltC 4210862 mltC Shigella flexneri 5 str. 8401 murein transglycosylase C YP_690396.1 3084320 D 373384 CDS YP_690397.1 110806877 4210863 3085604..3086860 1 NC_008258.1 Code: GEPR; COG: COG0477; nucleoside transporter permease 3086860 nupG 4210863 nupG Shigella flexneri 5 str. 8401 nucleoside transporter permease YP_690397.1 3085604 D 373384 CDS YP_690398.1 110806878 4210864 complement(3086909..3089104) 1 NC_008258.1 Code: E; COG: COG1982; ornithine decarboxylase 3089104 speC 4210864 speC Shigella flexneri 5 str. 8401 ornithine decarboxylase YP_690398.1 3086909 R 373384 CDS YP_690399.1 110806879 4210865 3089442..3090149 1 NC_008258.1 Code: R; COG: COG1811; transport protein 3090149 yqgA 4210865 yqgA Shigella flexneri 5 str. 8401 transport protein YP_690399.1 3089442 D 373384 CDS YP_690400.1 110806880 4210867 3090930..3091220 1 NC_008258.1 hypothetical protein 3091220 4210867 SFV_3027 Shigella flexneri 5 str. 8401 hypothetical protein YP_690400.1 3090930 D 373384 CDS YP_690401.1 110806881 4210868 complement(3091359..3091862) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3091862 insB 4210868 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690401.1 3091359 R 373384 CDS YP_690402.1 110806882 4210869 3091937..3092239 1 NC_008258.1 IS1 encoded protein 3092239 4210869 SFV_3029 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690402.1 3091937 D 373384 CDS YP_690403.1 110806883 4210870 complement(3093450..3095045) 1 NC_008258.1 Code: C; COG: COG1620; permease 3095045 yghK 4210870 yghK Shigella flexneri 5 str. 8401 permease YP_690403.1 3093450 R 373384 CDS YP_690404.1 110806884 4210871 complement(3095400..3097571) 1 NC_008258.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3097571 glcB 4210871 glcB Shigella flexneri 5 str. 8401 malate synthase G YP_690404.1 3095400 R 373384 CDS YP_690405.1 110806885 4210872 complement(3097593..3097997) 1 NC_008258.1 Code: R; COG: COG3193; hypothetical protein 3097997 glcG 4210872 glcG Shigella flexneri 5 str. 8401 hypothetical protein YP_690405.1 3097593 R 373384 CDS YP_690406.1 110806886 4210875 3102034..3102876 1 NC_008258.1 Code: K; COG: COG2186; DNA-binding transcriptional regulator GlcC 3102876 glcC 4210875 glcC Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator GlcC YP_690406.1 3102034 D 373384 CDS YP_690407.1 110806887 4210876 complement(3102935..3103264) 1 NC_008258.1 hypothetical protein 3103264 4210876 SFV_3036 Shigella flexneri 5 str. 8401 hypothetical protein YP_690407.1 3102935 R 373384 CDS YP_690408.1 110806888 4210877 complement(3103231..3104076) 1 NC_008258.1 hypothetical protein 3104076 4210877 SFV_3037 Shigella flexneri 5 str. 8401 hypothetical protein YP_690408.1 3103231 R 373384 CDS YP_690409.1 110806889 4210878 complement(3104285..3104536) 1 NC_008258.1 IS1 encoded protein 3104536 4210878 SFV_3038 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690409.1 3104285 R 373384 CDS YP_690410.1 110806890 4210805 3104611..3105114 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3105114 insB 4210805 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690410.1 3104611 D 373384 CDS YP_690411.1 110806891 4210807 complement(3105688..3107550) 1 NC_008258.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3107550 gsp 4210807 gsp Shigella flexneri 5 str. 8401 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_690411.1 3105688 R 373384 CDS YP_690412.1 110806892 4210808 3107752..3108618 1 NC_008258.1 YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase YghU 3108618 4210808 SFV_3042 Shigella flexneri 5 str. 8401 glutathione S-transferase YghU YP_690412.1 3107752 D 373384 CDS YP_690413.1 110806893 4210809 complement(3108741..3108989) 1 NC_008258.1 Code: O; COG: COG0298; hydrogenase 2 accessory protein HypG 3108989 hybG 4210809 hybG Shigella flexneri 5 str. 8401 hydrogenase 2 accessory protein HypG YP_690413.1 3108741 R 373384 CDS YP_690414.1 110806894 4210810 complement(3109123..3109464) 1 NC_008258.1 may modulate levels of hydrogenease-2; plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3109464 hybF 4210810 hybF Shigella flexneri 5 str. 8401 hydrogenase nickel incorporation protein HybF YP_690414.1 3109123 R 373384 CDS YP_690415.1 110806895 4210811 complement(3109457..3109945) 1 NC_008258.1 hydrogenase 2-specific chaperone 3109945 hybE 4210811 hybE Shigella flexneri 5 str. 8401 hydrogenase 2-specific chaperone YP_690415.1 3109457 R 373384 CDS YP_690416.1 110806896 4210812 complement(3109938..3110432) 1 NC_008258.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3110432 hybD 4210812 hybD Shigella flexneri 5 str. 8401 hydrogenase 2 maturation endopeptidase YP_690416.1 3109938 R 373384 CDS YP_690417.1 110806897 4210813 complement(3110432..3112135) 1 NC_008258.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3112135 hybC 4210813 hybC Shigella flexneri 5 str. 8401 hydrogenase 2 large subunit YP_690417.1 3110432 R 373384 CDS YP_690418.1 110806898 4210814 complement(3112132..3113310) 1 NC_008258.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 3113310 hybB 4210814 hybB Shigella flexneri 5 str. 8401 hydrogenase 2 b cytochrome subunit YP_690418.1 3112132 R 373384 CDS YP_690419.1 110806899 4210815 complement(3113300..3114286) 1 NC_008258.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3114286 hybA 4210815 hybA Shigella flexneri 5 str. 8401 hydrogenase 2 protein HybA YP_690419.1 3113300 R 373384 CDS YP_690420.1 110806900 4210816 complement(3114289..3115353) 1 NC_008258.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3115353 4210816 SFV_3050 Shigella flexneri 5 str. 8401 hydrogenase 2 small subunit YP_690420.1 3114289 R 373384 CDS YP_690421.1 110806901 4210817 complement(3115596..3115883) 1 NC_008258.1 hypothetical protein 3115883 4210817 SFV_3051 Shigella flexneri 5 str. 8401 hypothetical protein YP_690421.1 3115596 R 373384 CDS YP_690422.1 110806902 4210818 complement(3116002..3116889) 1 NC_008258.1 Code: Q; COG: COG0412; hydrolase 3116889 yghYX 4210818 yghYX Shigella flexneri 5 str. 8401 hydrolase YP_690422.1 3116002 R 373384 CDS YP_690423.1 110806903 4210819 3117046..3118086 1 NC_008258.1 Code: C; COG: COG0667; aldo/keto reductase 3118086 4210819 SFV_3053 Shigella flexneri 5 str. 8401 aldo/keto reductase YP_690423.1 3117046 D 373384 CDS YP_690424.1 110806904 4210820 complement(3118126..3118650) 1 NC_008258.1 Code: S; COG: COG2862; hypothetical protein 3118650 yqhA 4210820 yqhA Shigella flexneri 5 str. 8401 hypothetical protein YP_690424.1 3118126 R 373384 CDS YP_690425.1 110806905 4210821 3118811..3119695 1 NC_008258.1 Code: IQR; COG: COG1028; oxidoreductase 3119695 yghA 4210821 yghA Shigella flexneri 5 str. 8401 oxidoreductase YP_690425.1 3118811 D 373384 CDS YP_690426.1 110806906 4210822 complement(3119967..3120392) 1 NC_008258.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3120392 exbD 4210822 exbD Shigella flexneri 5 str. 8401 biopolymer transport protein ExbD YP_690426.1 3119967 R 373384 CDS YP_690427.1 110806907 4210823 complement(3120399..3121118) 1 NC_008258.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3121118 exbB 4210823 exbB Shigella flexneri 5 str. 8401 biopolymer transport protein ExbB YP_690427.1 3120399 R 373384 CDS YP_690428.1 110806908 4208781 3121250..3122572 1 NC_008258.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3122572 metC 4208781 metC Shigella flexneri 5 str. 8401 cystathionine beta-lyase YP_690428.1 3121250 D 373384 CDS YP_690429.1 110806909 4208782 3122712..3123371 1 NC_008258.1 Code: S; COG: COG0586; hypothetical protein 3123371 yghB 4208782 yghB Shigella flexneri 5 str. 8401 hypothetical protein YP_690429.1 3122712 D 373384 CDS YP_690430.1 110806910 4208783 3124503..3125666 1 NC_008258.1 Code: C; COG: COG1979; oxidoreductase 3125666 yqhD 4208783 yqhD Shigella flexneri 5 str. 8401 oxidoreductase YP_690430.1 3124503 D 373384 CDS YP_690431.1 110806911 4208785 3125771..3126598 1 NC_008258.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3126598 dkgA 4208785 dkgA Shigella flexneri 5 str. 8401 2,5-diketo-D-gluconate reductase A YP_690431.1 3125771 D 373384 CDS YP_690432.1 110806912 4208786 3126798..3127724 1 NC_008258.1 hypothetical protein 3127724 yqhG 4208786 yqhG Shigella flexneri 5 str. 8401 hypothetical protein YP_690432.1 3126798 D 373384 CDS YP_690433.1 110806913 4208787 3127775..3128032 1 NC_008258.1 Code: M; COG: COG4238; outer membrane lipoprotein 3128032 yqhH 4208787 yqhH Shigella flexneri 5 str. 8401 outer membrane lipoprotein YP_690433.1 3127775 D 373384 CDS YP_690434.1 110806914 4208789 complement(3130365..3131777) 1 NC_008258.1 Code: Q; COG: COG2132; repressor protein for FtsI 3131777 sufI 4208789 sufI Shigella flexneri 5 str. 8401 repressor protein for FtsI YP_690434.1 3130365 R 373384 CDS YP_690435.1 110806915 4208790 complement(3131852..3132589) 1 NC_008258.1 Code: I; COG: COG0204; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3132589 plsC 4208790 plsC Shigella flexneri 5 str. 8401 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_690435.1 3131852 R 373384 CDS YP_690436.1 110806916 4208791 complement(3132823..3135081) 1 NC_008258.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3135081 parC 4208791 parC Shigella flexneri 5 str. 8401 DNA topoisomerase IV subunit A YP_690436.1 3132823 R 373384 CDS YP_690437.1 110806917 4208792 complement(3135627..3136109) 1 NC_008258.1 Code: L; COG: COG3449; hypothetical protein 3136109 4208792 SFV_3069 Shigella flexneri 5 str. 8401 hypothetical protein YP_690437.1 3135627 R 373384 CDS YP_690438.1 110806918 4208793 complement(3136162..3136554) 1 NC_008258.1 Code: S; COG: COG3111; hypothetical protein 3136554 ygiW 4208793 ygiW Shigella flexneri 5 str. 8401 hypothetical protein YP_690438.1 3136162 R 373384 CDS YP_690439.1 110806919 4208794 3136733..3137365 1 NC_008258.1 quorum sensing Escherichia coli regulator B; response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3137365 qseB 4208794 qseB Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator QseB YP_690439.1 3136733 D 373384 CDS YP_690440.1 110806920 4208795 3137362..3138711 1 NC_008258.1 quorum sensing Escherichia coli regulator C; Code: T; COG: COG0642; sensor protein QseC 3138711 qseC 4208795 qseC Shigella flexneri 5 str. 8401 sensor protein QseC YP_690440.1 3137362 D 373384 CDS YP_690441.1 110806921 4208796 3139408..3139989 1 NC_008258.1 Code: R; COG: COG2249; modulator of drug activity B 3139989 mdaB 4208796 mdaB Shigella flexneri 5 str. 8401 modulator of drug activity B YP_690441.1 3139408 D 373384 CDS YP_690442.1 110806922 4208797 3140020..3140334 1 NC_008258.1 Code: S; COG: COG1359; hypothetical protein 3140334 ygiN 4208797 ygiN Shigella flexneri 5 str. 8401 hypothetical protein YP_690442.1 3140020 D 373384 CDS YP_690443.1 110806923 4208798 complement(3140382..3142274) 1 NC_008258.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3142274 parE 4208798 parE Shigella flexneri 5 str. 8401 DNA topoisomerase IV subunit B YP_690443.1 3140382 R 373384 CDS YP_690444.1 110806924 4208799 complement(3142303..3142884) 1 NC_008258.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase 3142884 yqiA 4208799 yqiA Shigella flexneri 5 str. 8401 esterase YP_690444.1 3142303 R 373384 CDS YP_690445.1 110806925 4208800 complement(3142884..3143711) 1 NC_008258.1 Code: R; COG: COG1409; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3143711 icc 4208800 icc Shigella flexneri 5 str. 8401 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_690445.1 3142884 R 373384 CDS YP_690446.1 110806926 4210710 complement(3143736..3144158) 1 NC_008258.1 Code: S; COG: COG3151; hypothetical protein 3144158 yqiB 4210710 yqiB Shigella flexneri 5 str. 8401 hypothetical protein YP_690446.1 3143736 R 373384 CDS YP_690447.1 110806927 4210711 complement(3144159..3144788) 1 NC_008258.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 3144788 nudF 4210711 nudF Shigella flexneri 5 str. 8401 ADP-ribose pyrophosphatase YP_690447.1 3144159 R 373384 CDS YP_690448.1 110806928 4210712 3144993..3146474 1 NC_008258.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3146474 tolC 4210712 tolC Shigella flexneri 5 str. 8401 outer membrane channel protein YP_690448.1 3144993 D 373384 CDS YP_690449.1 110806929 4210713 3146622..3147293 1 NC_008258.1 Code: S; COG: COG5463; hypothetical protein 3147293 ygiB 4210713 ygiB Shigella flexneri 5 str. 8401 hypothetical protein YP_690449.1 3146622 D 373384 CDS YP_690450.1 110806930 4210714 3147299..3148459 1 NC_008258.1 Code: E; COG: COG0754; synthetase/amidase 3148459 ygiC 4210714 ygiC Shigella flexneri 5 str. 8401 synthetase/amidase YP_690450.1 3147299 D 373384 CDS YP_690451.1 110806931 4210715 complement(3148497..3149312) 1 NC_008258.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3149312 ygiD 4210715 ygiD Shigella flexneri 5 str. 8401 hypothetical protein YP_690451.1 3148497 R 373384 CDS YP_690452.1 110806932 4210716 3149428..3150201 1 NC_008258.1 Code: P; COG: COG0428; zinc transporter ZupT 3150201 ygiE 4210716 ygiE Shigella flexneri 5 str. 8401 zinc transporter ZupT YP_690452.1 3149428 D 373384 CDS YP_690453.1 110806933 4210717 complement(3150690..3151343) 1 NC_008258.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3151343 ribB 4210717 ribB Shigella flexneri 5 str. 8401 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_690453.1 3150690 R 373384 CDS YP_690454.1 110806934 4210718 3151657..3152007 1 NC_008258.1 Code: S; COG: COG2960; hypothetical protein 3152007 4210718 SFV_3086 Shigella flexneri 5 str. 8401 hypothetical protein YP_690454.1 3151657 D 373384 CDS YP_690455.1 110806935 4210719 3152263..3152628 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3152628 4210719 SFV_3087 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_690455.1 3152263 D 373384 CDS YP_690456.2 162139330 4210720 3152586..3153437 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3153437 4210720 SFV_3088 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_690456.2 3152586 D 373384 CDS YP_690457.1 110806937 4210721 complement(3153416..3153607) 1 NC_008258.1 IS1 encoded protein 3153607 4210721 SFV_3089 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690457.1 3153416 R 373384 CDS YP_690458.1 110806938 4210722 3153682..3154185 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3154185 insB 4210722 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690458.1 3153682 D 373384 CDS YP_690459.1 110806939 4210724 complement(3156296..3157729) 1 NC_008258.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3157729 4210724 SFV_3092 Shigella flexneri 5 str. 8401 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_690459.1 3156296 R 373384 CDS YP_690460.1 110806940 4210725 complement(3157777..3160704) 1 NC_008258.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3160704 glnE 4210725 glnE Shigella flexneri 5 str. 8401 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_690460.1 3157777 R 373384 CDS YP_690461.1 110806941 4210726 complement(3160640..3161842) 1 NC_008258.1 Code: S; COG: COG3025; hypothetical protein 3161842 ygiF 4210726 ygiF Shigella flexneri 5 str. 8401 hypothetical protein YP_690461.1 3160640 R 373384 CDS YP_690462.1 110806942 4210727 3162183..3162803 1 NC_008258.1 Code: T; COG: COG3103; signal transduction protein 3162803 ygiM 4210727 ygiM Shigella flexneri 5 str. 8401 signal transduction protein YP_690462.1 3162183 D 373384 CDS YP_690463.1 110806943 4210728 3162867..3164105 1 NC_008258.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3164105 cca 4210728 cca Shigella flexneri 5 str. 8401 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_690463.1 3162867 D 373384 CDS YP_690464.1 110806944 4207080 complement(3164268..3165089) 1 NC_008258.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3165089 bacA 4207080 bacA Shigella flexneri 5 str. 8401 undecaprenyl pyrophosphate phosphatase YP_690464.1 3164268 R 373384 CDS YP_690465.1 110806945 4207081 complement(3165180..3165548) 1 NC_008258.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3165548 folB 4207081 folB Shigella flexneri 5 str. 8401 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_690465.1 3165180 R 373384 CDS YP_690466.1 110806946 4207082 3165653..3166270 1 NC_008258.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3166270 ygiH 4207082 ygiH Shigella flexneri 5 str. 8401 glycerol-3-phosphate acyltransferase PlsY YP_690466.1 3165653 D 373384 CDS YP_690467.1 110806947 4207083 complement(3166213..3167214) 1 NC_008258.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3167214 ygiP 4207083 ygiP Shigella flexneri 5 str. 8401 transcriptional activator TtdR YP_690467.1 3166213 R 373384 CDS YP_690468.1 110806948 4207084 3167421..3168233 1 NC_008258.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3168233 ttdA 4207084 ttdA Shigella flexneri 5 str. 8401 tartrate dehydratase subunit alpha YP_690468.1 3167421 D 373384 CDS YP_690469.1 110806949 4207085 3168261..3168866 1 NC_008258.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3168866 ttdB 4207085 ttdB Shigella flexneri 5 str. 8401 L(+)-tartrate dehydratase subunit beta YP_690469.1 3168261 D 373384 CDS YP_690470.1 110806950 4207086 3168914..3170377 1 NC_008258.1 Code: P; COG: COG0471; hypothetical protein 3170377 ygjE 4207086 ygjE Shigella flexneri 5 str. 8401 hypothetical protein YP_690470.1 3168914 D 373384 CDS YP_690471.1 110806951 4207087 complement(3170420..3171433) 1 NC_008258.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3171433 ygjD 4207087 ygjD Shigella flexneri 5 str. 8401 DNA-binding/iron metalloprotein/AP endonuclease YP_690471.1 3170420 R 373384 CDS YP_690472.1 110806952 4207088 3171671..3171886 1 NC_008258.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3171886 rpsU 4207088 rpsU Shigella flexneri 5 str. 8401 30S ribosomal protein S21 YP_690472.1 3171671 D 373384 CDS YP_690473.1 110806953 4207089 3171997..3173742 1 NC_008258.1 DNA biosynthesis; synthesizes RNA primers at the replication forks; DNA primase 3173742 dnaG 4207089 dnaG Shigella flexneri 5 str. 8401 DNA primase YP_690473.1 3171997 D 373384 CDS YP_690474.1 110806954 4207090 3173937..3175778 1 NC_008258.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3175778 rpoD 4207090 rpoD Shigella flexneri 5 str. 8401 RNA polymerase sigma factor RpoD YP_690474.1 3173937 D 373384 CDS YP_690475.1 110806955 4207091 3175916..3177262 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 3177262 4207091 SFV_3108 Shigella flexneri 5 str. 8401 IS4 orf YP_690475.1 3175916 D 373384 CDS YP_690476.1 110806956 4207092 complement(3177294..3177800) 1 NC_008258.1 Code: L; COG: COG3663; G/U mismatch-specific DNA glycosylase 3177800 ygjF 4207092 ygjF Shigella flexneri 5 str. 8401 G/U mismatch-specific DNA glycosylase YP_690476.1 3177294 R 373384 CDS YP_690477.1 110806957 4207095 3179076..3179699 1 NC_008258.1 Code: K; COG: COG1695; hypothetical protein 3179699 yqjI 4207095 yqjI Shigella flexneri 5 str. 8401 hypothetical protein YP_690477.1 3179076 D 373384 CDS YP_690478.1 110806958 4207097 3181791..3183170 1 NC_008258.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3183170 ygjG 4207097 ygjG Shigella flexneri 5 str. 8401 putrescine--2-oxoglutarate aminotransferase YP_690478.1 3181791 D 373384 CDS YP_690479.1 110806959 4207547 3183763..3184746 1 NC_008258.1 Code: K; COG: COG1609; DNA-binding transcriptional repressor EbgR 3184746 ebgR 4207547 ebgR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor EbgR YP_690479.1 3183763 D 373384 CDS YP_690480.1 110806960 4207548 3184930..3188016 1 NC_008258.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3188016 ebgA 4207548 ebgA Shigella flexneri 5 str. 8401 cryptic beta-D-galactosidase subunit alpha YP_690480.1 3184930 D 373384 CDS YP_690481.1 110806961 4207549 3188013..3188462 1 NC_008258.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3188462 ebgC 4207549 ebgC Shigella flexneri 5 str. 8401 cryptic beta-D-galactosidase subunit beta YP_690481.1 3188013 D 373384 CDS YP_690482.1 110806962 4207550 3188525..3189958 1 NC_008258.1 Code: E; COG: COG0531; oxidoreductase 3189958 ygjI 4207550 ygjI Shigella flexneri 5 str. 8401 oxidoreductase YP_690482.1 3188525 D 373384 CDS YP_690483.1 110806963 4207553 3193757..3195775 1 NC_008258.1 NADPH dehydrogenase 3195775 ygjL 4207553 ygjL Shigella flexneri 5 str. 8401 NADPH dehydrogenase YP_690483.1 3193757 D 373384 CDS YP_690484.1 110806964 4207554 complement(3195820..3196236) 1 NC_008258.1 Code: K; COG: COG5499; hypothetical protein 3196236 ygjM 4207554 ygjM Shigella flexneri 5 str. 8401 hypothetical protein YP_690484.1 3195820 R 373384 CDS YP_690485.1 110806965 4207555 complement(3196233..3196547) 1 NC_008258.1 Code: S; COG: COG4680; hypothetical protein 3196547 ygjN 4207555 ygjN Shigella flexneri 5 str. 8401 hypothetical protein YP_690485.1 3196233 R 373384 CDS YP_690486.1 110806967 4207557 complement(3196832..3198277) 1 NC_008258.1 Code: J; COG: COG2813; hypothetical protein 3198277 ygjO 4207557 ygjO Shigella flexneri 5 str. 8401 hypothetical protein YP_690486.1 3196832 R 373384 CDS YP_690487.1 110806966 4207556 3198257..3198556 1 NC_008258.1 hypothetical protein 3198556 4207556 SFV_3125 Shigella flexneri 5 str. 8401 hypothetical protein YP_690487.1 3198257 D 373384 CDS YP_690488.1 110806968 4207558 3198633..3199325 1 NC_008258.1 Code: S; COG: COG2949; hypothetical protein 3199325 ygjQ 4207558 ygjQ Shigella flexneri 5 str. 8401 hypothetical protein YP_690488.1 3198633 D 373384 CDS YP_690489.1 110806969 4207559 3199404..3200402 1 NC_008258.1 Code: R; COG: COG0673; hypothetical protein 3200402 ygjR 4207559 ygjR Shigella flexneri 5 str. 8401 hypothetical protein YP_690489.1 3199404 D 373384 CDS YP_690490.1 110806970 4207560 3200673..3201638 1 NC_008258.1 Code: P; COG: COG0861; transport protein 3201638 ygjT 4207560 ygjT Shigella flexneri 5 str. 8401 transport protein YP_690490.1 3200673 D 373384 CDS YP_690491.1 110806971 4207561 3202234..3203478 1 NC_008258.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3203478 ygjU 4207561 ygjU Shigella flexneri 5 str. 8401 serine/threonine transporter SstT YP_690491.1 3202234 D 373384 CDS YP_690492.1 110806972 4207562 complement(3203483..3204034) 1 NC_008258.1 hypothetical protein 3204034 ygjV 4207562 ygjV Shigella flexneri 5 str. 8401 hypothetical protein YP_690492.1 3203483 R 373384 CDS YP_690493.1 110806973 4207563 complement(3204117..3205604) 1 NC_008258.1 Code: G; COG: COG2721; altronate hydrolase 3205604 uxaA 4207563 uxaA Shigella flexneri 5 str. 8401 altronate hydrolase YP_690493.1 3204117 R 373384 CDS YP_690494.1 110806974 4207564 complement(3205619..3207031) 1 NC_008258.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3207031 uxaC 4207564 uxaC Shigella flexneri 5 str. 8401 glucuronate isomerase YP_690494.1 3205619 R 373384 CDS YP_690495.1 110806975 4207565 3207347..3208813 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein of hexuronates 3208813 exuT 4207565 exuT Shigella flexneri 5 str. 8401 transport protein of hexuronates YP_690495.1 3207347 D 373384 CDS YP_690496.1 110806976 4208914 complement(3208901..3209989) 1 NC_008258.1 hypothetical protein 3209989 4208914 SFV_3135 Shigella flexneri 5 str. 8401 hypothetical protein YP_690496.1 3208901 R 373384 CDS YP_690497.1 110806977 4208915 complement(3209986..3212835) 1 NC_008258.1 outer membrane fimbrial user protein 3212835 tsaC 4208915 tsaC Shigella flexneri 5 str. 8401 outer membrane fimbrial user protein YP_690497.1 3209986 R 373384 CDS YP_690498.1 110806978 4208916 3212949..3213452 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3213452 insB 4208916 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690498.1 3212949 D 373384 CDS YP_690499.1 110806979 4208917 3213560..3214336 1 NC_008258.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3214336 exuR 4208917 exuR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor ExuR YP_690499.1 3213560 D 373384 CDS YP_690500.1 110806980 4208918 3214681..3215343 1 NC_008258.1 Code: S; COG: COG0586; hypothetical protein 3215343 yqjA 4208918 yqjA Shigella flexneri 5 str. 8401 hypothetical protein YP_690500.1 3214681 D 373384 CDS YP_690501.1 110806981 4208919 3215347..3215730 1 NC_008258.1 hypothetical protein 3215730 yqjB 4208919 yqjB Shigella flexneri 5 str. 8401 hypothetical protein YP_690501.1 3215347 D 373384 CDS YP_690502.1 110806982 4208920 3215877..3216311 1 NC_008258.1 hypothetical protein 3216311 yqjC 4208920 yqjC Shigella flexneri 5 str. 8401 hypothetical protein YP_690502.1 3215877 D 373384 CDS YP_690503.1 110806983 4208921 3216269..3216574 1 NC_008258.1 Code: S; COG: COG4575; hypothetical protein 3216574 yqjD 4208921 yqjD Shigella flexneri 5 str. 8401 hypothetical protein YP_690503.1 3216269 D 373384 CDS YP_690504.1 110806984 4208922 3216577..3216981 1 NC_008258.1 Code: S; COG: COG5393; hypothetical protein 3216981 yqjE 4208922 yqjE Shigella flexneri 5 str. 8401 hypothetical protein YP_690504.1 3216577 D 373384 CDS YP_690505.1 110806985 4208923 3216971..3217270 1 NC_008258.1 hypothetical protein 3217270 4208923 SFV_3144 Shigella flexneri 5 str. 8401 hypothetical protein YP_690505.1 3216971 D 373384 CDS YP_690506.1 110806986 4208924 3217366..3217752 1 NC_008258.1 Code: S; COG: COG2259; hypothetical protein 3217752 yqjF 4208924 yqjF Shigella flexneri 5 str. 8401 hypothetical protein YP_690506.1 3217366 D 373384 CDS YP_690507.1 110806987 4208925 3217822..3218808 1 NC_008258.1 Code: O; COG: COG0435; transferase 3218808 yqjG 4208925 yqjG Shigella flexneri 5 str. 8401 transferase YP_690507.1 3217822 D 373384 CDS YP_690508.1 110806988 4208926 3219080..3219469 1 NC_008258.1 Code: S; COG: COG3152; cytochrome 3219469 yhaH 4208926 yhaH Shigella flexneri 5 str. 8401 cytochrome YP_690508.1 3219080 D 373384 CDS YP_690509.1 110806989 4208927 complement(3219676..3220572) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 3220572 yhaJ 4208927 yhaJ Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_690509.1 3219676 R 373384 CDS YP_690510.1 110806990 4208928 3220677..3221378 1 NC_008258.1 Code: R; COG: COG1741; hypothetical protein 3221378 yhaK 4208928 yhaK Shigella flexneri 5 str. 8401 hypothetical protein YP_690510.1 3220677 D 373384 CDS YP_690511.1 110806991 4208929 3221401..3221565 1 NC_008258.1 hypothetical protein 3221565 yhaL 4208929 yhaL Shigella flexneri 5 str. 8401 hypothetical protein YP_690511.1 3221401 D 373384 CDS YP_690512.1 110806992 4208930 complement(3221777..3223087) 1 NC_008258.1 Code: S; COG: COG3681; hypothetical protein 3223087 yhaNM 4208930 yhaNM Shigella flexneri 5 str. 8401 hypothetical protein YP_690512.1 3221777 R 373384 CDS YP_690513.1 110806993 4208931 complement(3223115..3224383) 1 NC_008258.1 Code: E; COG: COG0814; transport system permease 3224383 yhaO 4208931 yhaO Shigella flexneri 5 str. 8401 transport system permease YP_690513.1 3223115 R 373384 CDS YP_690514.1 110806994 4208932 complement(3224721..3226085) 1 NC_008258.1 Code: E; COG: COG1760; L-serine deaminase 3226085 yhaP 4208932 yhaP Shigella flexneri 5 str. 8401 L-serine deaminase YP_690514.1 3224721 R 373384 CDS YP_690515.1 110806995 4208933 complement(3226157..3226609) 1 NC_008258.1 Code: J; COG: COG0251; hypothetical protein 3226609 yhaR 4208933 yhaR Shigella flexneri 5 str. 8401 hypothetical protein YP_690515.1 3226157 R 373384 CDS YP_690516.1 110806996 4207342 complement(3226560..3228854) 1 NC_008258.1 Code: C; COG: COG1882; formate acetyltransferase 3 3228854 tdcE 4207342 tdcE Shigella flexneri 5 str. 8401 formate acetyltransferase 3 YP_690516.1 3226560 R 373384 CDS YP_690517.2 162139329 4207343 complement(3228888..3230108) 1 NC_008258.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3230108 tdcD 4207343 tdcD Shigella flexneri 5 str. 8401 propionate/acetate kinase YP_690517.2 3228888 R 373384 CDS YP_690518.1 110806998 4207344 complement(3230122..3231453) 1 NC_008258.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3231453 tdcC 4207344 tdcC Shigella flexneri 5 str. 8401 threonine/serine transporter TdcC YP_690518.1 3230122 R 373384 CDS YP_690519.1 110806999 4207345 complement(3231475..3232464) 1 NC_008258.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3232464 tdcB 4207345 tdcB Shigella flexneri 5 str. 8401 threonine dehydratase YP_690519.1 3231475 R 373384 CDS YP_690520.1 110807000 4207346 complement(3232563..3233501) 1 NC_008258.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3233501 tdcA 4207346 tdcA Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator TdcA YP_690520.1 3232563 R 373384 CDS YP_690521.1 110807001 4207347 3233691..3234035 1 NC_008258.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3234035 tdcR 4207347 tdcR Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator TdcR YP_690521.1 3233691 D 373384 CDS YP_690522.1 110807002 4207348 3234291..3234830 1 NC_008258.1 hypothetical protein 3234830 yhaB 4207348 yhaB Shigella flexneri 5 str. 8401 hypothetical protein YP_690522.1 3234291 D 373384 CDS YP_690523.1 110807003 4207349 3234852..3235568 1 NC_008258.1 hypothetical protein 3235568 yhaC 4207349 yhaC Shigella flexneri 5 str. 8401 hypothetical protein YP_690523.1 3234852 D 373384 CDS YP_690524.1 110807004 4207350 3236641..3237030 1 NC_008258.1 hypothetical protein 3237030 4207350 SFV_3163 Shigella flexneri 5 str. 8401 hypothetical protein YP_690524.1 3236641 D 373384 CDS YP_690525.1 110807005 4207351 complement(3237049..3238275) 1 NC_008258.1 Code: G; COG: COG1929; glycerate kinase I 3238275 yhaD 4207351 yhaD Shigella flexneri 5 str. 8401 glycerate kinase I YP_690525.1 3237049 R 373384 CDS YP_690526.1 110807006 4207352 complement(3238291..3239175) 1 NC_008258.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3239175 garR 4207352 garR Shigella flexneri 5 str. 8401 tartronate semialdehyde reductase YP_690526.1 3238291 R 373384 CDS YP_690527.1 110807007 4207353 complement(3239211..3239756) 1 NC_008258.1 Code: G; COG: COG3836; hypothetical protein 3239756 yhaF 4207353 yhaF Shigella flexneri 5 str. 8401 hypothetical protein YP_690527.1 3239211 R 373384 CDS YP_690528.1 110807008 4207354 complement(3239997..3241283) 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 3241283 yhaU 4207354 yhaU Shigella flexneri 5 str. 8401 transport protein YP_690528.1 3239997 R 373384 CDS YP_690529.1 110807009 4207355 complement(3241285..3241788) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3241788 insB 4207355 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690529.1 3241285 R 373384 CDS YP_690530.1 110807010 4207356 3241863..3242042 1 NC_008258.1 IS1 encoded protein 3242042 4207356 SFV_3169 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690530.1 3241863 D 373384 CDS YP_690531.1 110807011 4207358 3242618..3243313 1 NC_008258.1 Code: NU; COG: COG3121; chaperone 3243313 yraI 4207358 yraI Shigella flexneri 5 str. 8401 chaperone YP_690531.1 3242618 D 373384 CDS YP_690532.1 110807012 4207360 complement(3245078..3245917) 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 3245917 4207360 SFV_3173 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_690532.1 3245078 R 373384 CDS YP_690533.1 110807013 4209727 complement(3245941..3246306) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3246306 4209727 SFV_3174 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_690533.1 3245941 R 373384 CDS YP_690534.1 110807014 4209728 3247205..3248296 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial protein 3248296 yraK 4209728 yraK Shigella flexneri 5 str. 8401 fimbrial protein YP_690534.1 3247205 D 373384 CDS YP_690535.1 110807015 4209729 complement(3248339..3249199) 1 NC_008258.1 Code: R; COG: COG0313; hypothetical protein 3249199 yraL 4209729 yraL Shigella flexneri 5 str. 8401 hypothetical protein YP_690535.1 3248339 R 373384 CDS YP_690536.1 110807016 4209730 3249234..3251300 1 NC_008258.1 Code: R; COG: COG3107; glycosylase 3251300 yraM 4209730 yraM Shigella flexneri 5 str. 8401 glycosylase YP_690536.1 3249234 D 373384 CDS YP_690537.1 110807017 4209731 3251258..3251653 1 NC_008258.1 Code: L; COG: COG0792; hypothetical protein 3251653 yraN 4209731 yraN Shigella flexneri 5 str. 8401 hypothetical protein YP_690537.1 3251258 D 373384 CDS YP_690538.1 110807018 4209732 3251673..3252263 1 NC_008258.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; chromosome replication initiator DnaA 3252263 yraO 4209732 yraO Shigella flexneri 5 str. 8401 chromosome replication initiator DnaA YP_690538.1 3251673 D 373384 CDS YP_690539.1 110807019 4209733 3252273..3252848 1 NC_008258.1 Code: R; COG: COG2823; hypothetical protein 3252848 yraP 4209733 yraP Shigella flexneri 5 str. 8401 hypothetical protein YP_690539.1 3252273 D 373384 CDS YP_690540.1 110807020 4209734 complement(3252962..3254002) 1 NC_008258.1 Code: R; COG: COG0701; hypothetical protein 3254002 yraQ 4209734 yraQ Shigella flexneri 5 str. 8401 hypothetical protein YP_690540.1 3252962 R 373384 CDS YP_690541.1 110807021 4209735 complement(3254075..3254710) 1 NC_008258.1 Code: MG; COG: COG0702; hypothetical protein 3254710 yraR 4209735 yraR Shigella flexneri 5 str. 8401 hypothetical protein YP_690541.1 3254075 R 373384 CDS YP_690542.1 110807022 4209736 3254838..3255356 1 NC_008258.1 Code: R; COG: COG0693; hypothetical protein 3255356 yhbO 4209736 yhbO Shigella flexneri 5 str. 8401 hypothetical protein YP_690542.1 3254838 D 373384 CDS YP_690543.1 110807023 4209737 complement(3255336..3255779) 1 NC_008258.1 Code: S; COG: COG3787; hypothetical protein 3255779 yhbP 4209737 yhbP Shigella flexneri 5 str. 8401 hypothetical protein YP_690543.1 3255336 R 373384 CDS YP_690544.1 110807024 4209738 3255821..3256132 1 NC_008258.1 Code: L; COG: COG2827; GIY-YIG nuclease superfamily protein 3256132 yhbQ 4209738 yhbQ Shigella flexneri 5 str. 8401 GIY-YIG nuclease superfamily protein YP_690544.1 3255821 D 373384 CDS YP_690545.1 110807025 4209739 complement(3256119..3256622) 1 NC_008258.1 Code: R; COG: COG3153; hypothetical protein 3256622 yhbS 4209739 yhbS Shigella flexneri 5 str. 8401 hypothetical protein YP_690545.1 3256119 R 373384 CDS YP_690546.1 110807026 4209740 complement(3256616..3257140) 1 NC_008258.1 Code: I; COG: COG3154; hypothetical protein 3257140 yhbT 4209740 yhbT Shigella flexneri 5 str. 8401 hypothetical protein YP_690546.1 3256616 R 373384 CDS YP_690547.1 110807027 4209741 3257349..3258344 1 NC_008258.1 Code: O; COG: COG0826; collagenase 3258344 yhbU 4209741 yhbU Shigella flexneri 5 str. 8401 collagenase YP_690547.1 3257349 D 373384 CDS YP_690548.1 110807028 4209742 3258353..3259198 1 NC_008258.1 Code: O; COG: COG0826; hypothetical protein 3259198 yhbV 4209742 yhbV Shigella flexneri 5 str. 8401 hypothetical protein YP_690548.1 3258353 D 373384 CDS YP_690549.1 110807029 4209743 3259312..3260319 1 NC_008258.1 Code: C; COG: COG2141; hypothetical protein 3260319 yhbW 4209743 yhbW Shigella flexneri 5 str. 8401 hypothetical protein YP_690549.1 3259312 D 373384 CDS YP_690550.1 110807030 4209744 complement(3260437..3261681) 1 NC_008258.1 tryptophan transporter of high affinity; tryptophan permease 3261681 mtr 4209744 mtr Shigella flexneri 5 str. 8401 tryptophan permease YP_690550.1 3260437 R 373384 CDS YP_690551.1 110807031 4209745 complement(3261835..3263790) 1 NC_008258.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3263790 deaD 4209745 deaD Shigella flexneri 5 str. 8401 ATP-dependent RNA helicase DeaD YP_690551.1 3261835 R 373384 CDS YP_690552.1 110807032 4209746 complement(3263904..3264788) 1 NC_008258.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3264788 yhbM 4209746 yhbM Shigella flexneri 5 str. 8401 lipoprotein NlpI YP_690552.1 3263904 R 373384 CDS YP_690553.1 110807033 4207684 complement(3264897..3267032) 1 NC_008258.1 Code: J; COG: COG1185; polynucleotide phosphorylase 3267032 pnp 4207684 pnp Shigella flexneri 5 str. 8401 polynucleotide phosphorylase YP_690553.1 3264897 R 373384 CDS YP_690554.1 110807034 4207685 complement(3267279..3267548) 1 NC_008258.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3267548 rpsO 4207685 rpsO Shigella flexneri 5 str. 8401 30S ribosomal protein S15 YP_690554.1 3267279 R 373384 CDS YP_690555.1 110807035 4207686 complement(3267697..3268641) 1 NC_008258.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3268641 truB 4207686 truB Shigella flexneri 5 str. 8401 tRNA pseudouridine synthase B YP_690555.1 3267697 R 373384 CDS YP_690556.1 110807036 4207687 complement(3268641..3269042) 1 NC_008258.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3269042 rbfA 4207687 rbfA Shigella flexneri 5 str. 8401 ribosome-binding factor A YP_690556.1 3268641 R 373384 CDS YP_690557.1 110807037 4207688 complement(3269206..3271854) 1 NC_008258.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3271854 infB 4207688 infB Shigella flexneri 5 str. 8401 translation initiation factor IF-2 YP_690557.1 3269206 R 373384 CDS YP_690558.1 110807038 4207689 complement(3271879..3273366) 1 NC_008258.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3273366 nusA 4207689 nusA Shigella flexneri 5 str. 8401 transcription elongation factor NusA YP_690558.1 3271879 R 373384 CDS YP_690559.1 110807039 4207690 complement(3273394..3273846) 1 NC_008258.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3273846 yhbC 4207690 yhbC Shigella flexneri 5 str. 8401 hypothetical protein YP_690559.1 3273394 R 373384 CDS YP_690560.1 110807040 4207692 3274477..3275820 1 NC_008258.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3275820 argG 4207692 argG Shigella flexneri 5 str. 8401 argininosuccinate synthase YP_690560.1 3274477 D 373384 CDS YP_690561.2 162139328 4207695 complement(3278014..3278346) 1 NC_008258.1 Code: U; COG: COG1314; preprotein translocase subunit SecG 3278346 secG 4207695 secG Shigella flexneri 5 str. 8401 preprotein translocase subunit SecG YP_690561.2 3278014 R 373384 CDS YP_690562.1 110807042 4207696 complement(3278573..3279910) 1 NC_008258.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3279910 glmM 4207696 glmM Shigella flexneri 5 str. 8401 phosphoglucosamine mutase YP_690562.1 3278573 R 373384 CDS YP_690563.1 110807043 4207697 complement(3279903..3280751) 1 NC_008258.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3280751 folP 4207697 folP Shigella flexneri 5 str. 8401 dihydropteroate synthase YP_690563.1 3279903 R 373384 CDS YP_690564.1 110807044 4207698 complement(3280841..3282775) 1 NC_008258.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3282775 hflB 4207698 hflB Shigella flexneri 5 str. 8401 ATP-dependent metalloprotease YP_690564.1 3280841 R 373384 CDS YP_690565.1 110807045 4207699 complement(3282875..3283504) 1 NC_008258.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase 3283504 rrmJ 4207699 rrmJ Shigella flexneri 5 str. 8401 23S rRNA methyltransferase YP_690565.1 3282875 R 373384 CDS YP_690566.1 110807046 4207700 3283630..3283923 1 NC_008258.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3283923 yhbY 4207700 yhbY Shigella flexneri 5 str. 8401 RNA-binding protein YhbY YP_690566.1 3283630 D 373384 CDS YP_690567.1 110807047 4208342 complement(3284079..3284555) 1 NC_008258.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3284555 greA 4208342 greA Shigella flexneri 5 str. 8401 transcription elongation factor GreA YP_690567.1 3284079 R 373384 CDS YP_690568.1 110807048 4208343 3284803..3286236 1 NC_008258.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase/endopeptidase 3286236 dacB 4208343 dacB Shigella flexneri 5 str. 8401 D-alanyl-D-alanine carboxypeptidase/endopeptidase YP_690568.1 3284803 D 373384 CDS YP_690569.1 110807049 4208344 complement(3286422..3287594) 1 NC_008258.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3287594 obgE 4208344 obgE Shigella flexneri 5 str. 8401 GTPase ObgE YP_690569.1 3286422 R 373384 CDS YP_690570.1 110807050 4208345 complement(3287610..3288575) 1 NC_008258.1 Code: GER; COG: COG0697; hypothetical protein 3288575 yhbE 4208345 yhbE Shigella flexneri 5 str. 8401 hypothetical protein YP_690570.1 3287610 R 373384 CDS YP_690571.1 110807051 4208346 complement(3288702..3288959) 1 NC_008258.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3288959 rpmA 4208346 rpmA Shigella flexneri 5 str. 8401 50S ribosomal protein L27 YP_690571.1 3288702 R 373384 CDS YP_690572.1 110807052 4208347 complement(3288980..3289291) 1 NC_008258.1 50S ribosomal protein L21 3289291 rplU 4208347 rplU Shigella flexneri 5 str. 8401 50S ribosomal protein L21 YP_690572.1 3288980 R 373384 CDS YP_690573.1 110807053 4208348 3289549..3290520 1 NC_008258.1 Code: H; COG: COG0142; octaprenyl diphosphate synthase 3290520 ispB 4208348 ispB Shigella flexneri 5 str. 8401 octaprenyl diphosphate synthase YP_690573.1 3289549 D 373384 CDS YP_690574.1 110807054 4208349 3290747..3291025 1 NC_008258.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3291025 nlp 4208349 nlp Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator Nlp YP_690574.1 3290747 D 373384 CDS YP_690575.1 110807055 4208350 complement(3291073..3292332) 1 NC_008258.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3292332 murA 4208350 murA Shigella flexneri 5 str. 8401 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_690575.1 3291073 R 373384 CDS YP_690576.1 110807056 4208351 complement(3292387..3292656) 1 NC_008258.1 Code: K; COG: COG5007; hypothetical protein 3292656 yrbA 4208351 yrbA Shigella flexneri 5 str. 8401 hypothetical protein YP_690576.1 3292387 R 373384 CDS YP_690577.1 110807057 4208352 complement(3292801..3293190) 1 NC_008258.1 Code: R; COG: COG3113; hypothetical protein 3293190 yrbB 4208352 yrbB Shigella flexneri 5 str. 8401 hypothetical protein YP_690577.1 3292801 R 373384 CDS YP_690578.1 110807058 4208353 complement(3293094..3293729) 1 NC_008258.1 Code: Q; COG: COG2854; hypothetical protein 3293729 yrbC 4208353 yrbC Shigella flexneri 5 str. 8401 hypothetical protein YP_690578.1 3293094 R 373384 CDS YP_690579.1 110807059 4208354 complement(3293748..3294299) 1 NC_008258.1 Code: Q; COG: COG1463; cytoplasmic membrane protein 3294299 yrbD 4208354 yrbD Shigella flexneri 5 str. 8401 cytoplasmic membrane protein YP_690579.1 3293748 R 373384 CDS YP_690580.1 110807060 4208355 complement(3294304..3295086) 1 NC_008258.1 Code: Q; COG: COG0767; hypothetical protein 3295086 yrbE 4208355 yrbE Shigella flexneri 5 str. 8401 hypothetical protein YP_690580.1 3294304 R 373384 CDS YP_690581.1 110807061 4208356 complement(3295094..3295903) 1 NC_008258.1 ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein YrbF 3295903 yrbF 4208356 yrbF Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YrbF YP_690581.1 3295094 R 373384 CDS YP_690582.1 110807062 4208357 3296113..3297078 1 NC_008258.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3297078 yrbG 4208357 yrbG Shigella flexneri 5 str. 8401 calcium/sodium:proton antiporter YP_690582.1 3296113 D 373384 CDS YP_690583.1 110807063 4208358 3297071..3298078 1 NC_008258.1 Code: M; COG: COG0794; D-arabinose 5-phosphate isomerase 3298078 yrbH 4208358 yrbH Shigella flexneri 5 str. 8401 D-arabinose 5-phosphate isomerase YP_690583.1 3297071 D 373384 CDS YP_690584.1 110807064 4208359 3298099..3298665 1 NC_008258.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3298665 yrbI 4208359 yrbI Shigella flexneri 5 str. 8401 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_690584.1 3298099 D 373384 CDS YP_690585.1 110807065 4208360 3298662..3299237 1 NC_008258.1 Code: S; COG: COG3117; hypothetical protein 3299237 yrbK 4208360 yrbK Shigella flexneri 5 str. 8401 hypothetical protein YP_690585.1 3298662 D 373384 CDS YP_690586.1 110807066 4208361 3299185..3299763 1 NC_008258.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3299763 yhbN 4208361 yhbN Shigella flexneri 5 str. 8401 lipopolysaccharide transport periplasmic protein LptA YP_690586.1 3299185 D 373384 CDS YP_690587.1 110807067 4209269 3299770..3300495 1 NC_008258.1 Code: R; COG: COG1137; ABC transporter ATP-binding protein YhbG 3300495 yhbG 4209269 yhbG Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YhbG YP_690587.1 3299770 D 373384 CDS YP_690588.1 110807068 4209270 3300543..3301976 1 NC_008258.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3301976 rpoN 4209270 rpoN Shigella flexneri 5 str. 8401 RNA polymerase factor sigma-54 YP_690588.1 3300543 D 373384 CDS YP_690589.1 110807069 4209271 3301999..3302286 1 NC_008258.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3302286 yhbH 4209271 yhbH Shigella flexneri 5 str. 8401 sigma(54) modulation protein YP_690589.1 3301999 D 373384 CDS YP_690590.1 110807070 4209272 3302404..3302895 1 NC_008258.1 Code: GT; COG: COG1762; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3302895 ptsN 4209272 ptsN Shigella flexneri 5 str. 8401 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_690590.1 3302404 D 373384 CDS YP_690591.1 110807071 4209273 3302941..3303795 1 NC_008258.1 Code: R; COG: COG1660; hypothetical protein 3303795 yhbJ 4209273 yhbJ Shigella flexneri 5 str. 8401 hypothetical protein YP_690591.1 3302941 D 373384 CDS YP_690592.1 110807072 4209274 3303792..3304064 1 NC_008258.1 Code: G; COG: COG1925; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3304064 ptsO 4209274 ptsO Shigella flexneri 5 str. 8401 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_690592.1 3303792 D 373384 CDS YP_690593.1 110807073 4209275 3304277..3304771 1 NC_008258.1 hypothetical protein 3304771 yrbL 4209275 yrbL Shigella flexneri 5 str. 8401 hypothetical protein YP_690593.1 3304277 D 373384 CDS YP_690594.1 110807074 4209277 complement(3305630..3306283) 1 NC_008258.1 Code: Q; COG: COG3155; isoprenoid biosynthesis protein with amidotransferase-like domain 3306283 yhbL 4209277 yhbL Shigella flexneri 5 str. 8401 isoprenoid biosynthesis protein with amidotransferase-like domain YP_690594.1 3305630 R 373384 CDS YP_690595.1 110807075 4209278 complement(3306513..3308849) 1 NC_008258.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3308849 arcB 4209278 arcB Shigella flexneri 5 str. 8401 aerobic respiration control sensor protein ArcB YP_690595.1 3306513 R 373384 CDS YP_690596.1 110807076 4209279 complement(3308945..3309850) 1 NC_008258.1 Code: R; COG: COG1242; hypothetical protein 3309850 yhcC 4209279 yhcC Shigella flexneri 5 str. 8401 hypothetical protein YP_690596.1 3308945 R 373384 CDS YP_690597.1 110807077 4209280 3310549..3315009 1 NC_008258.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3315009 gltB 4209280 gltB Shigella flexneri 5 str. 8401 glutamate synthase subunit alpha YP_690597.1 3310549 D 373384 CDS YP_690598.1 110807078 4209281 3315022..3316440 1 NC_008258.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3316440 gltD 4209281 gltD Shigella flexneri 5 str. 8401 glutamate synthase subunit beta YP_690598.1 3315022 D 373384 CDS YP_690599.1 110807079 4209282 3317177..3317479 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 3317479 4209282 SFV_3244 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690599.1 3317177 D 373384 CDS YP_690600.1 110807080 4209283 3317620..3318333 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 3318333 4209283 SFV_3245 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_690600.1 3317620 D 373384 CDS YP_690601.1 110807081 4209284 complement(3318767..3319231) 1 NC_008258.1 Code: G; COG: COG2731; hypothetical protein 3319231 yhcH 4209284 yhcH Shigella flexneri 5 str. 8401 hypothetical protein YP_690601.1 3318767 R 373384 CDS YP_690602.1 110807082 4209285 complement(3319228..3320103) 1 NC_008258.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3320103 yhcI 4209285 yhcI Shigella flexneri 5 str. 8401 N-acetylmannosamine kinase YP_690602.1 3319228 R 373384 CDS YP_690603.1 110807083 4209286 complement(3320100..3320789) 1 NC_008258.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3320789 yhcJ 4209286 yhcJ Shigella flexneri 5 str. 8401 N-acetylmannosamine-6-phosphate 2-epimerase YP_690603.1 3320100 R 373384 CDS YP_690604.1 110807084 4209287 complement(3320837..3322327) 1 NC_008258.1 Code: GEPR; COG: COG0477; sialic acid transporter 3322327 nanT 4209287 nanT Shigella flexneri 5 str. 8401 sialic acid transporter YP_690604.1 3320837 R 373384 CDS YP_690605.1 110807085 4207664 complement(3322437..3323330) 1 NC_008258.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3323330 nanA 4207664 nanA Shigella flexneri 5 str. 8401 N-acetylneuraminate lyase YP_690605.1 3322437 R 373384 CDS YP_690606.1 110807086 4207665 complement(3323452..3324234) 1 NC_008258.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3324234 yhcK 4207665 yhcK Shigella flexneri 5 str. 8401 transcriptional regulator NanR YP_690606.1 3323452 R 373384 CDS YP_690607.1 110807087 4207666 complement(3324513..3324800) 1 NC_008258.1 IS1 encoded protein 3324800 4207666 SFV_3252 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690607.1 3324513 R 373384 CDS YP_690608.1 110807088 4207667 3324875..3325378 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3325378 insB 4207667 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690608.1 3324875 D 373384 CDS YP_690609.1 110807089 4207668 3325504..3326766 1 NC_008258.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 3326766 yhcL 4207668 yhcL Shigella flexneri 5 str. 8401 cryptic C4-dicarboxylate transporter DcuD YP_690609.1 3325504 D 373384 CDS YP_690610.1 110807090 4207669 complement(3326809..3327306) 1 NC_008258.1 Code: R; COG: COG2969; ClpXP protease specificity-enhancing factor 3327306 sspB 4207669 sspB Shigella flexneri 5 str. 8401 ClpXP protease specificity-enhancing factor YP_690610.1 3326809 R 373384 CDS YP_690611.1 110807091 4207670 complement(3327312..3327950) 1 NC_008258.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3327950 sspA 4207670 sspA Shigella flexneri 5 str. 8401 stringent starvation protein A YP_690611.1 3327312 R 373384 CDS YP_690612.1 110807092 4207671 complement(3328345..3328737) 1 NC_008258.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3328737 rpsI 4207671 rpsI Shigella flexneri 5 str. 8401 30S ribosomal protein S9 YP_690612.1 3328345 R 373384 CDS YP_690613.2 162139327 4207672 complement(3328753..3329181) 1 NC_008258.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3329181 rplM 4207672 rplM Shigella flexneri 5 str. 8401 50S ribosomal protein L13 YP_690613.2 3328753 R 373384 CDS YP_690614.1 110807094 4207673 complement(3329400..3330527) 1 NC_008258.1 Code: R; COG: COG1485; hypothetical protein 3330527 yhcM 4207673 yhcM Shigella flexneri 5 str. 8401 hypothetical protein YP_690614.1 3329400 R 373384 CDS YP_690615.1 110807095 4207674 3330721..3331119 1 NC_008258.1 Code: S; COG: COG3105; cytochrome d ubiquinol oxidase subunit III 3331119 yhcB 4207674 yhcB Shigella flexneri 5 str. 8401 cytochrome d ubiquinol oxidase subunit III YP_690615.1 3330721 D 373384 CDS YP_690616.1 110807096 4207675 3331273..3332640 1 NC_008258.1 Code: O; COG: COG0265; serine endoprotease 3332640 degQ 4207675 degQ Shigella flexneri 5 str. 8401 serine endoprotease YP_690616.1 3331273 D 373384 CDS YP_690617.1 110807097 4207676 3332730..3333797 1 NC_008258.1 Code: O; COG: COG0265; serine endoprotease 3333797 degS 4207676 degS Shigella flexneri 5 str. 8401 serine endoprotease YP_690617.1 3332730 D 373384 CDS YP_690618.1 110807098 4207677 complement(3333859..3334797) 1 NC_008258.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3334797 mdh 4207677 mdh Shigella flexneri 5 str. 8401 malate dehydrogenase YP_690618.1 3333859 R 373384 CDS YP_690619.1 110807099 4207678 3335232..3335702 1 NC_008258.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3335702 argR 4207678 argR Shigella flexneri 5 str. 8401 arginine repressor ArgR YP_690619.1 3335232 D 373384 CDS YP_690620.1 110807100 4207679 3336016..3336330 1 NC_008258.1 hypothetical protein 3336330 yhcN 4207679 yhcN Shigella flexneri 5 str. 8401 hypothetical protein YP_690620.1 3336016 D 373384 CDS YP_690621.1 110807101 4207680 complement(3336386..3336658) 1 NC_008258.1 Code: K; COG: COG2732; hypothetical protein 3336658 yhcO 4207680 yhcO Shigella flexneri 5 str. 8401 hypothetical protein YP_690621.1 3336386 R 373384 CDS YP_690622.1 110807102 4207681 complement(3336750..3338717) 1 NC_008258.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3338717 yhcP 4207681 yhcP Shigella flexneri 5 str. 8401 p-hydroxybenzoic acid efflux subunit AaeB YP_690622.1 3336750 R 373384 CDS YP_690623.1 110807103 4207682 complement(3338723..3339655) 1 NC_008258.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3339655 yhcQ 4207682 yhcQ Shigella flexneri 5 str. 8401 p-hydroxybenzoic acid efflux subunit AaeA YP_690623.1 3338723 R 373384 CDS YP_690624.2 229774935 4207683 complement(3339663..3339866) 1 NC_008258.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3339866 yhcR 4207683 yhcR Shigella flexneri 5 str. 8401 hypothetical protein YP_690624.2 3339663 R 373384 CDS YP_690625.1 110807105 4210538 3340049..3340978 1 NC_008258.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 3340978 qseA 4210538 qseA Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_690625.1 3340049 D 373384 CDS YP_690626.1 110807106 4210539 complement(3341106..3342551) 1 NC_008258.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3342551 tldD 4210539 tldD Shigella flexneri 5 str. 8401 protease TldD YP_690626.1 3341106 R 373384 CDS YP_690627.1 110807107 4210540 complement(3342707..3346507) 1 NC_008258.1 Code: S; COG: COG3164; hypothetical protein 3346507 yhdRP 4210540 yhdRP Shigella flexneri 5 str. 8401 hypothetical protein YP_690627.1 3342707 R 373384 CDS YP_690628.1 110807108 4210541 complement(3346575..3348044) 1 NC_008258.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3348044 cafA 4210541 cafA Shigella flexneri 5 str. 8401 ribonuclease G YP_690628.1 3346575 R 373384 CDS YP_690629.1 110807109 4210542 complement(3348034..3348627) 1 NC_008258.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3348627 yhdE 4210542 yhdE Shigella flexneri 5 str. 8401 Maf-like protein YP_690629.1 3348034 R 373384 CDS YP_690630.1 110807110 4210543 complement(3348636..3349124) 1 NC_008258.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3349124 mreD 4210543 mreD Shigella flexneri 5 str. 8401 rod shape-determining protein MreD YP_690630.1 3348636 R 373384 CDS YP_690631.1 110807111 4210544 complement(3349124..3350209) 1 NC_008258.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3350209 mreC 4210544 mreC Shigella flexneri 5 str. 8401 rod shape-determining protein MreC YP_690631.1 3349124 R 373384 CDS YP_690632.2 229774934 4210545 complement(3350275..3351318) 1 NC_008258.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3351318 mreB 4210545 mreB Shigella flexneri 5 str. 8401 rod shape-determining protein MreB YP_690632.2 3350275 R 373384 CDS YP_690633.1 110807113 4210546 complement(3351623..3353563) 1 NC_008258.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3353563 yhdA 4210546 yhdA Shigella flexneri 5 str. 8401 regulatory protein CsrD YP_690633.1 3351623 R 373384 CDS YP_690634.1 110807114 4210547 3353715..3354689 1 NC_008258.1 Code: CR; COG: COG0604; dehydrogenase 3354689 yhdH 4210547 yhdH Shigella flexneri 5 str. 8401 dehydrogenase YP_690634.1 3353715 D 373384 CDS YP_690635.1 110807115 4210548 3355667..3356137 1 NC_008258.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3356137 accB 4210548 accB Shigella flexneri 5 str. 8401 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_690635.1 3355667 D 373384 CDS YP_690636.1 110807116 4210549 3356148..3357497 1 NC_008258.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3357497 accC 4210549 accC Shigella flexneri 5 str. 8401 acetyl-CoA carboxylase biotin carboxylase subunit YP_690636.1 3356148 D 373384 CDS YP_690637.1 110807117 4210550 3357606..3357848 1 NC_008258.1 Code: S; COG: COG3924; hypothetical protein 3357848 yhdT 4210550 yhdT Shigella flexneri 5 str. 8401 hypothetical protein YP_690637.1 3357606 D 373384 CDS YP_690638.1 110807118 4210551 3357838..3359289 1 NC_008258.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3359289 panF 4210551 panF Shigella flexneri 5 str. 8401 sodium/panthothenate symporter YP_690638.1 3357838 D 373384 CDS YP_690639.1 110807119 4210552 3359301..3360182 1 NC_008258.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 3360182 prmA 4210552 prmA Shigella flexneri 5 str. 8401 ribosomal protein L11 methyltransferase YP_690639.1 3359301 D 373384 CDS YP_690640.1 110807120 4210553 3360511..3361476 1 NC_008258.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase B 3361476 yhdG 4210553 yhdG Shigella flexneri 5 str. 8401 tRNA-dihydrouridine synthase B YP_690640.1 3360511 D 373384 CDS YP_690641.1 110807121 4210554 3361502..3361798 1 NC_008258.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; Fis family transcriptional regulator 3361798 fis 4210554 fis Shigella flexneri 5 str. 8401 Fis family transcriptional regulator YP_690641.1 3361502 D 373384 CDS YP_690642.1 110807122 4210555 3361884..3362768 1 NC_008258.1 Code: L; COG: COG0863; methyltransferase 3362768 yhdJ 4210555 yhdJ Shigella flexneri 5 str. 8401 methyltransferase YP_690642.1 3361884 D 373384 CDS YP_690643.1 110807123 4210556 complement(3363046..3363549) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3363549 insB 4210556 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690643.1 3363046 R 373384 CDS YP_690644.1 110807124 4211068 3363642..3363950 1 NC_008258.1 IS1 encoded protein 3363950 4211068 SFV_3289 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690644.1 3363642 D 373384 CDS YP_690645.1 110807125 4211069 3363979..3365004 1 NC_008258.1 Code: ET; COG: COG0834; periplasmic binding transport protein 3365004 yhdW 4211069 yhdW Shigella flexneri 5 str. 8401 periplasmic binding transport protein YP_690645.1 3363979 D 373384 CDS YP_690646.1 110807126 4211071 3366252..3367355 1 NC_008258.1 Code: E; COG: COG0765; transport system permease 3367355 yhdY 4211071 yhdY Shigella flexneri 5 str. 8401 transport system permease YP_690646.1 3366252 D 373384 CDS YP_690647.1 110807127 4211072 3367363..3368121 1 NC_008258.1 Code: E; COG: COG1126; ABC transporter ATP-binding protein 3368121 yhdZ 4211072 yhdZ Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_690647.1 3367363 D 373384 CDS YP_690648.1 110807128 4211079 3373615..3374463 1 NC_008258.1 Code: R; COG: COG0663; transferase 3374463 yrdA 4211079 yrdA Shigella flexneri 5 str. 8401 transferase YP_690648.1 3373615 D 373384 CDS YP_690649.1 110807129 4211080 complement(3374439..3374696) 1 NC_008258.1 hypothetical protein 3374696 yrdB 4211080 yrdB Shigella flexneri 5 str. 8401 hypothetical protein YP_690649.1 3374439 R 373384 CDS YP_690650.1 110807130 4211081 complement(3374693..3375511) 1 NC_008258.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3375511 aroE 4211081 aroE Shigella flexneri 5 str. 8401 shikimate 5-dehydrogenase YP_690650.1 3374693 R 373384 CDS YP_690651.1 110807131 4211011 complement(3375516..3376133) 1 NC_008258.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 3376133 yrdC 4211011 yrdC Shigella flexneri 5 str. 8401 ribosome maturation factor YP_690651.1 3375516 R 373384 CDS YP_690652.1 110807132 4211012 complement(3376664..3377137) 1 NC_008258.1 Code: S; COG: COG2922; hypothetical protein 3377137 smg 4211012 smg Shigella flexneri 5 str. 8401 hypothetical protein YP_690652.1 3376664 R 373384 CDS YP_690653.1 110807133 4211013 complement(3377109..3378233) 1 NC_008258.1 Code: LU; COG: COG0758; DNA protecting protein DprA 3378233 smf 4211013 smf Shigella flexneri 5 str. 8401 DNA protecting protein DprA YP_690653.1 3377109 R 373384 CDS YP_690654.1 110807134 4211014 3378398..3378907 1 NC_008258.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3378907 def 4211014 def Shigella flexneri 5 str. 8401 peptide deformylase YP_690654.1 3378398 D 373384 CDS YP_690655.1 110807135 4211015 3378922..3379869 1 NC_008258.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3379869 fmt 4211015 fmt Shigella flexneri 5 str. 8401 methionyl-tRNA formyltransferase YP_690655.1 3378922 D 373384 CDS YP_690656.1 110807136 4211016 3379894..3381204 1 NC_008258.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3381204 sun 4211016 sun Shigella flexneri 5 str. 8401 16S rRNA methyltransferase GidB YP_690656.1 3379894 D 373384 CDS YP_690657.1 110807137 4211017 3381226..3382602 1 NC_008258.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 3382602 trkA 4211017 trkA Shigella flexneri 5 str. 8401 potassium transporter peripheral membrane component YP_690657.1 3381226 D 373384 CDS YP_690658.1 110807138 4211018 3382783..3383457 1 NC_008258.1 ISSfl4 ORF1 3383457 4211018 SFV_3310 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_690658.1 3382783 D 373384 CDS YP_690659.1 110807139 4211019 3383454..3383801 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 3383801 4211019 SFV_3311 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_690659.1 3383454 D 373384 CDS YP_690660.1 110807140 4211020 3383821..3385422 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF3 3385422 4211020 SFV_3312 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_690660.1 3383821 D 373384 CDS YP_690661.1 110807141 4211021 complement(3385426..3385713) 1 NC_008258.1 Code: L; COG: COG4584; ISSfl4 ORF1 3385713 4211021 SFV_3313 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_690661.1 3385426 R 373384 CDS YP_690662.1 110807142 4211022 complement(3385883..3386266) 1 NC_008258.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3386266 rplQ 4211022 rplQ Shigella flexneri 5 str. 8401 50S ribosomal protein L17 YP_690662.1 3385883 R 373384 CDS YP_690663.1 110807143 4211023 complement(3386307..3387296) 1 NC_008258.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3387296 rpoA 4211023 rpoA Shigella flexneri 5 str. 8401 DNA-directed RNA polymerase subunit alpha YP_690663.1 3386307 R 373384 CDS YP_690664.1 110807144 4211024 complement(3387322..3387942) 1 NC_008258.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3387942 rpsD 4211024 rpsD Shigella flexneri 5 str. 8401 30S ribosomal protein S4 YP_690664.1 3387322 R 373384 CDS YP_690665.1 110807145 4211025 complement(3387976..3388365) 1 NC_008258.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3388365 rpsK 4211025 rpsK Shigella flexneri 5 str. 8401 30S ribosomal protein S11 YP_690665.1 3387976 R 373384 CDS YP_690666.1 110807146 4211026 complement(3388382..3388738) 1 NC_008258.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3388738 rpsM 4211026 rpsM Shigella flexneri 5 str. 8401 30S ribosomal protein S13 YP_690666.1 3388382 R 373384 CDS YP_690667.1 110807147 4211027 complement(3388885..3389001) 1 NC_008258.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3389001 rpmJ 4211027 rpmJ Shigella flexneri 5 str. 8401 50S ribosomal protein L36 YP_690667.1 3388885 R 373384 CDS YP_690668.1 110807148 4211028 complement(3389033..3390364) 1 NC_008258.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3390364 secY 4211028 secY Shigella flexneri 5 str. 8401 preprotein translocase subunit SecY YP_690668.1 3389033 R 373384 CDS YP_690669.1 110807149 4211029 complement(3390372..3390806) 1 NC_008258.1 late assembly protein; 50S ribosomal protein L15 3390806 rplO 4211029 rplO Shigella flexneri 5 str. 8401 50S ribosomal protein L15 YP_690669.1 3390372 R 373384 CDS YP_690670.1 110807150 4210557 complement(3390810..3390989) 1 NC_008258.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3390989 rpmD 4210557 rpmD Shigella flexneri 5 str. 8401 50S ribosomal protein L30 YP_690670.1 3390810 R 373384 CDS YP_690671.1 110807151 4210558 complement(3390993..3391496) 1 NC_008258.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3391496 rpsE 4210558 rpsE Shigella flexneri 5 str. 8401 30S ribosomal protein S5 YP_690671.1 3390993 R 373384 CDS YP_690672.1 110807152 4210559 complement(3391511..3391864) 1 NC_008258.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3391864 rplR 4210559 rplR Shigella flexneri 5 str. 8401 50S ribosomal protein L18 YP_690672.1 3391511 R 373384 CDS YP_690673.1 110807153 4210560 complement(3391874..3392407) 1 NC_008258.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3392407 rplF 4210560 rplF Shigella flexneri 5 str. 8401 50S ribosomal protein L6 YP_690673.1 3391874 R 373384 CDS YP_690674.1 110807154 4210561 complement(3392420..3392812) 1 NC_008258.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3392812 rpsH 4210561 rpsH Shigella flexneri 5 str. 8401 30S ribosomal protein S8 YP_690674.1 3392420 R 373384 CDS YP_690675.1 110807155 4210562 complement(3392846..3393151) 1 NC_008258.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3393151 rpsN 4210562 rpsN Shigella flexneri 5 str. 8401 30S ribosomal protein S14 YP_690675.1 3392846 R 373384 CDS YP_690676.1 110807156 4210563 complement(3393166..3393705) 1 NC_008258.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3393705 rplE 4210563 rplE Shigella flexneri 5 str. 8401 50S ribosomal protein L5 YP_690676.1 3393166 R 373384 CDS YP_690677.1 110807157 4210564 complement(3393720..3394034) 1 NC_008258.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3394034 rplX 4210564 rplX Shigella flexneri 5 str. 8401 50S ribosomal protein L24 YP_690677.1 3393720 R 373384 CDS YP_690678.1 110807158 4210565 complement(3394045..3394416) 1 NC_008258.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3394416 rplN 4210565 rplN Shigella flexneri 5 str. 8401 50S ribosomal protein L14 YP_690678.1 3394045 R 373384 CDS YP_690679.1 110807159 4210566 complement(3394581..3394835) 1 NC_008258.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3394835 rpsQ 4210566 rpsQ Shigella flexneri 5 str. 8401 30S ribosomal protein S17 YP_690679.1 3394581 R 373384 CDS YP_690680.1 110807160 4210567 complement(3394835..3395026) 1 NC_008258.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3395026 rpmC 4210567 rpmC Shigella flexneri 5 str. 8401 50S ribosomal protein L29 YP_690680.1 3394835 R 373384 CDS YP_690681.1 110807161 4210568 complement(3395026..3395436) 1 NC_008258.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3395436 rplP 4210568 rplP Shigella flexneri 5 str. 8401 50S ribosomal protein L16 YP_690681.1 3395026 R 373384 CDS YP_690682.1 110807162 4210569 complement(3395449..3396150) 1 NC_008258.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3396150 rpsC 4210569 rpsC Shigella flexneri 5 str. 8401 30S ribosomal protein S3 YP_690682.1 3395449 R 373384 CDS YP_690683.1 110807163 4210570 complement(3396168..3396500) 1 NC_008258.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3396500 rplV 4210570 rplV Shigella flexneri 5 str. 8401 50S ribosomal protein L22 YP_690683.1 3396168 R 373384 CDS YP_690684.1 110807164 4210571 complement(3396810..3397631) 1 NC_008258.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3397631 rplB 4210571 rplB Shigella flexneri 5 str. 8401 50S ribosomal protein L2 YP_690684.1 3396810 R 373384 CDS YP_690685.1 110807165 4210572 complement(3397649..3397951) 1 NC_008258.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3397951 rplW 4210572 rplW Shigella flexneri 5 str. 8401 50S ribosomal protein L23 YP_690685.1 3397649 R 373384 CDS YP_690686.1 110807166 4210573 complement(3397948..3398553) 1 NC_008258.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3398553 rplD 4210573 rplD Shigella flexneri 5 str. 8401 50S ribosomal protein L4 YP_690686.1 3397948 R 373384 CDS YP_690687.1 110807167 4210574 complement(3398564..3399193) 1 NC_008258.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3399193 rplC 4210574 rplC Shigella flexneri 5 str. 8401 50S ribosomal protein L3 YP_690687.1 3398564 R 373384 CDS YP_690688.1 110807168 4210575 complement(3399226..3399537) 1 NC_008258.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3399537 rpsJ 4210575 rpsJ Shigella flexneri 5 str. 8401 30S ribosomal protein S10 YP_690688.1 3399226 R 373384 CDS YP_690689.1 110807169 4210576 3399916..3400383 1 NC_008258.1 Code: NOU; COG: COG1989; leader peptidase 3400383 hopD 4210576 hopD Shigella flexneri 5 str. 8401 leader peptidase YP_690689.1 3399916 D 373384 CDS YP_690690.1 110807170 4211049 complement(3400380..3400856) 1 NC_008258.1 iron storage protein; bacterioferritin 3400856 bfr 4211049 bfr Shigella flexneri 5 str. 8401 bacterioferritin YP_690690.1 3400380 R 373384 CDS YP_690691.1 110807171 4211050 complement(3400929..3401123) 1 NC_008258.1 Code: P; COG: COG2906; bacterioferritin-associated ferredoxin 3401123 yheA 4211050 yheA Shigella flexneri 5 str. 8401 bacterioferritin-associated ferredoxin YP_690691.1 3400929 R 373384 CDS YP_690692.1 110807172 4211051 complement(3401306..3402490) 1 NC_008258.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3402490 tufA 4211051 tufA Shigella flexneri 5 str. 8401 elongation factor Tu YP_690692.1 3401306 R 373384 CDS YP_690693.1 110807173 4211052 complement(3402561..3404675) 1 NC_008258.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3404675 fusA 4211052 fusA Shigella flexneri 5 str. 8401 elongation factor G YP_690693.1 3402561 R 373384 CDS YP_690694.1 110807174 4211053 complement(3404703..3405242) 1 NC_008258.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3405242 rpsG 4211053 rpsG Shigella flexneri 5 str. 8401 30S ribosomal protein S7 YP_690694.1 3404703 R 373384 CDS YP_690695.1 110807175 4211054 complement(3405339..3405713) 1 NC_008258.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3405713 rpsL 4211054 rpsL Shigella flexneri 5 str. 8401 30S ribosomal protein S12 YP_690695.1 3405339 R 373384 CDS YP_690696.1 110807176 4211055 complement(3405839..3406126) 1 NC_008258.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3406126 yheL 4211055 yheL Shigella flexneri 5 str. 8401 sulfur transfer complex subunit TusB YP_690696.1 3405839 R 373384 CDS YP_690697.1 110807177 4211056 complement(3406134..3406493) 1 NC_008258.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3406493 yheM 4211056 yheM Shigella flexneri 5 str. 8401 sulfur relay protein TusC YP_690697.1 3406134 R 373384 CDS YP_690698.1 110807178 4211057 complement(3406493..3406879) 1 NC_008258.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3406879 yheN 4211057 yheN Shigella flexneri 5 str. 8401 sulfur transfer complex subunit TusD YP_690698.1 3406493 R 373384 CDS YP_690699.1 110807179 4211058 complement(3406879..3407601) 1 NC_008258.1 Code: S; COG: COG2964; hypothetical protein 3407601 yheO 4211058 yheO Shigella flexneri 5 str. 8401 hypothetical protein YP_690699.1 3406879 R 373384 CDS YP_690700.1 110807180 4211059 complement(3407768..3408580) 1 NC_008258.1 rotamase; FKBP-type peptidylprolyl isomerase 3408580 fkpA 4211059 fkpA Shigella flexneri 5 str. 8401 FKBP-type peptidylprolyl isomerase YP_690700.1 3407768 R 373384 CDS YP_690701.1 110807181 4211060 3408801..3409019 1 NC_008258.1 Code: S; COG: COG2900; hypothetical protein 3409019 slyX 4211060 slyX Shigella flexneri 5 str. 8401 hypothetical protein YP_690701.1 3408801 D 373384 CDS YP_690702.1 110807182 4211061 complement(3409068..3409658) 1 NC_008258.1 rotamase; FKBP-type peptidylprolyl isomerase 3409658 slyD 4211061 slyD Shigella flexneri 5 str. 8401 FKBP-type peptidylprolyl isomerase YP_690702.1 3409068 R 373384 CDS YP_690703.1 110807183 4211062 complement(3409753..3409953) 1 NC_008258.1 Code: R; COG: COG3529; hypothetical protein 3409953 4211062 SFV_3355 Shigella flexneri 5 str. 8401 hypothetical protein YP_690703.1 3409753 R 373384 CDS YP_690704.1 110807184 4211063 complement(3409963..3411675) 1 NC_008258.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3411675 kefB 4211063 kefB Shigella flexneri 5 str. 8401 glutathione-regulated potassium-efflux system protein KefB YP_690704.1 3409963 R 373384 CDS YP_690705.1 110807185 4211064 complement(3411739..3412290) 1 NC_008258.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3412290 yheR 4211064 yheR Shigella flexneri 5 str. 8401 glutathione-regulated potassium-efflux system ancillary protein KefG YP_690705.1 3411739 R 373384 CDS YP_690706.1 110807186 4211065 3412421..3414334 1 NC_008258.1 Code: R; COG: COG0488; ABC transporter ATP-binding protein 3414334 yheS 4211065 yheS Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_690706.1 3412421 D 373384 CDS YP_690707.1 110807187 4211066 3414334..3415383 1 NC_008258.1 Code: R; COG: COG0429; hydrolase 3415383 yheT 4211066 yheT Shigella flexneri 5 str. 8401 hydrolase YP_690707.1 3414334 D 373384 CDS YP_690708.1 110807188 4211067 3415350..3415568 1 NC_008258.1 Code: S; COG: COG3089; hypothetical protein 3415568 yheU 4211067 yheU Shigella flexneri 5 str. 8401 hypothetical protein YP_690708.1 3415350 D 373384 CDS YP_690709.1 110807189 4206780 3415622..3416491 1 NC_008258.1 Code: C; COG: COG3954; phosphoribulokinase 3416491 prkB 4206780 prkB Shigella flexneri 5 str. 8401 phosphoribulokinase YP_690709.1 3415622 D 373384 CDS YP_690710.1 110807190 4206781 complement(3416546..3416950) 1 NC_008258.1 Code: O; COG: COG1765; hypothetical protein 3416950 yhfA 4206781 yhfA Shigella flexneri 5 str. 8401 hypothetical protein YP_690710.1 3416546 R 373384 CDS YP_690711.1 110807191 4206782 3417252..3417884 1 NC_008258.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3417884 crp 4206782 crp Shigella flexneri 5 str. 8401 cAMP-regulatory protein YP_690711.1 3417252 D 373384 CDS YP_690712.1 110807192 4206783 3417935..3420025 1 NC_008258.1 Code: S; COG: COG1289; hypothetical protein 3420025 yhfK 4206783 yhfK Shigella flexneri 5 str. 8401 hypothetical protein YP_690712.1 3417935 D 373384 CDS YP_690713.1 110807193 4206784 complement(3420092..3421312) 1 NC_008258.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase 3421312 argD 4206784 argD Shigella flexneri 5 str. 8401 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase YP_690713.1 3420092 R 373384 CDS YP_690714.1 110807194 4206785 complement(3421398..3421961) 1 NC_008258.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3421961 pabA 4206785 pabA Shigella flexneri 5 str. 8401 para-aminobenzoate synthase component II YP_690714.1 3421398 R 373384 CDS YP_690715.1 110807195 4206786 complement(3421993..3422595) 1 NC_008258.1 Code: D; COG: COG2184; cell filamentation protein Fic 3422595 fic 4206786 fic Shigella flexneri 5 str. 8401 cell filamentation protein Fic YP_690715.1 3421993 R 373384 CDS YP_690716.1 110807196 4206787 complement(3422585..3422752) 1 NC_008258.1 hypothetical protein 3422752 yhfG 4206787 yhfG Shigella flexneri 5 str. 8401 hypothetical protein YP_690716.1 3422585 R 373384 CDS YP_690717.1 110807197 4206788 complement(3422857..3423438) 1 NC_008258.1 Code: O; COG: COG0652; peptidyl-prolyl cis-trans isomerase A 3423438 ppiA 4206788 ppiA Shigella flexneri 5 str. 8401 peptidyl-prolyl cis-trans isomerase A YP_690717.1 3422857 R 373384 CDS YP_690718.1 110807198 4206789 3423709..3424890 1 NC_008258.1 Code: GEPR; COG: COG0477; hypothetical protein 3424890 yhfC 4206789 yhfC Shigella flexneri 5 str. 8401 hypothetical protein YP_690718.1 3423709 D 373384 CDS YP_690719.1 110807199 4206790 3425152..3427695 1 NC_008258.1 Code: C; COG: COG1251; nitrite reductase (NAD(P)H) subunit 3427695 nirB 4206790 nirB Shigella flexneri 5 str. 8401 nitrite reductase (NAD(P)H) subunit YP_690719.1 3425152 D 373384 CDS YP_690720.1 110807200 4206791 3427692..3428018 1 NC_008258.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3428018 nirD 4206791 nirD Shigella flexneri 5 str. 8401 nitrite reductase small subunit YP_690720.1 3427692 D 373384 CDS YP_690721.1 110807201 4206792 3428144..3428950 1 NC_008258.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3428950 nirC 4206792 nirC Shigella flexneri 5 str. 8401 nitrite transporter NirC YP_690721.1 3428144 D 373384 CDS YP_690722.1 110807202 4206793 3428969..3430342 1 NC_008258.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3430342 cysG 4206793 cysG Shigella flexneri 5 str. 8401 siroheme synthase YP_690722.1 3428969 D 373384 CDS YP_690723.1 110807203 4206794 3430589..3430756 1 NC_008258.1 hypothetical protein 3430756 yhfL 4206794 yhfL Shigella flexneri 5 str. 8401 hypothetical protein YP_690723.1 3430589 D 373384 CDS YP_690724.1 110807204 4206796 3432388..3433431 1 NC_008258.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3433431 frlB 4206796 frlB Shigella flexneri 5 str. 8401 fructoselysine-6-P-deglycase YP_690724.1 3432388 D 373384 CDS YP_690725.1 110807205 4206797 3433481..3434311 1 NC_008258.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 3434311 yhfP 4206797 yhfP Shigella flexneri 5 str. 8401 fructoselysine 3-epimerase YP_690725.1 3433481 D 373384 CDS YP_690726.1 110807206 4206798 3434308..3435093 1 NC_008258.1 Code: G; COG: COG0524; fructoselysine 6-kinase 3435093 yhfQ 4206798 yhfQ Shigella flexneri 5 str. 8401 fructoselysine 6-kinase YP_690726.1 3434308 D 373384 CDS YP_690727.1 110807207 4206799 3435127..3435924 1 NC_008258.1 may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3435924 yhfR 4206799 yhfR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator FrlR YP_690727.1 3435127 D 373384 CDS YP_690728.1 110807208 4208186 complement(3436084..3437169) 1 NC_008258.1 hypothetical protein 3437169 yhfS 4208186 yhfS Shigella flexneri 5 str. 8401 hypothetical protein YP_690728.1 3436084 R 373384 CDS YP_690729.1 110807209 4208187 complement(3437181..3438485) 1 NC_008258.1 transport system permease 3438485 yhfT 4208187 yhfT Shigella flexneri 5 str. 8401 transport system permease YP_690729.1 3437181 R 373384 CDS YP_690730.1 110807210 4208188 complement(3438497..3438889) 1 NC_008258.1 hypothetical protein 3438889 yhfU 4208188 yhfU Shigella flexneri 5 str. 8401 hypothetical protein YP_690730.1 3438497 R 373384 CDS YP_690731.1 110807211 4208189 complement(3438861..3439739) 1 NC_008258.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 3439739 yhfV 4208189 yhfV Shigella flexneri 5 str. 8401 hydrolase YP_690731.1 3438861 R 373384 CDS YP_690732.1 110807212 4208190 complement(3439736..3440962) 1 NC_008258.1 Code: G; COG: COG1015; mutase 3440962 yhfW 4208190 yhfW Shigella flexneri 5 str. 8401 mutase YP_690732.1 3439736 R 373384 CDS YP_690733.1 110807213 4208191 complement(3440963..3442126) 1 NC_008258.1 Code: E; COG: COG3457; hypothetical protein 3442126 yhfX 4208191 yhfX Shigella flexneri 5 str. 8401 hypothetical protein YP_690733.1 3440963 R 373384 CDS YP_690734.1 110807214 4208192 complement(3442210..3442614) 1 NC_008258.1 hypothetical protein 3442614 yhfY 4208192 yhfY Shigella flexneri 5 str. 8401 hypothetical protein YP_690734.1 3442210 R 373384 CDS YP_690735.1 110807215 4208193 complement(3442589..3443437) 1 NC_008258.1 hypothetical protein 3443437 yhfZ 4208193 yhfZ Shigella flexneri 5 str. 8401 hypothetical protein YP_690735.1 3442589 R 373384 CDS YP_690736.1 110807216 4208194 complement(3443764..3444768) 1 NC_008258.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3444768 trpS 4208194 trpS Shigella flexneri 5 str. 8401 tryptophanyl-tRNA synthetase YP_690736.1 3443764 R 373384 CDS YP_690737.1 110807217 4208195 complement(3444761..3445519) 1 NC_008258.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3445519 gph 4208195 gph Shigella flexneri 5 str. 8401 phosphoglycolate phosphatase YP_690737.1 3444761 R 373384 CDS YP_690738.1 110807218 4208196 complement(3445512..3446189) 1 NC_008258.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3446189 rpe 4208196 rpe Shigella flexneri 5 str. 8401 ribulose-phosphate 3-epimerase YP_690738.1 3445512 R 373384 CDS YP_690739.1 110807219 4208197 complement(3446207..3447043) 1 NC_008258.1 Code: L; COG: COG0338; DNA adenine methylase 3447043 dam 4208197 dam Shigella flexneri 5 str. 8401 DNA adenine methylase YP_690739.1 3446207 R 373384 CDS YP_690740.1 110807220 4208198 complement(3447150..3448436) 1 NC_008258.1 Code: S; COG: COG3266; hypothetical protein 3448436 damX 4208198 damX Shigella flexneri 5 str. 8401 hypothetical protein YP_690740.1 3447150 R 373384 CDS YP_690741.1 110807221 4208199 complement(3448528..3449616) 1 NC_008258.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3449616 aroB 4208199 aroB Shigella flexneri 5 str. 8401 3-dehydroquinate synthase YP_690741.1 3448528 R 373384 CDS YP_690742.2 229774933 4208200 complement(3449673..3450194) 1 NC_008258.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3450194 aroK 4208200 aroK Shigella flexneri 5 str. 8401 shikimate kinase I YP_690742.2 3449673 R 373384 CDS YP_690743.2 229774932 4208201 complement(3450595..3451833) 1 NC_008258.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; porin 3451833 hofQ 4208201 hofQ Shigella flexneri 5 str. 8401 porin YP_690743.2 3450595 R 373384 CDS YP_690744.1 110807224 4208202 complement(3451745..3452149) 1 NC_008258.1 hypothetical protein 3452149 yrfA 4208202 yrfA Shigella flexneri 5 str. 8401 hypothetical protein YP_690744.1 3451745 R 373384 CDS YP_690745.1 110807225 4208203 complement(3452139..3452579) 1 NC_008258.1 hypothetical protein 3452579 yrfB 4208203 yrfB Shigella flexneri 5 str. 8401 hypothetical protein YP_690745.1 3452139 R 373384 CDS YP_690746.1 110807226 4208204 complement(3452563..3453102) 1 NC_008258.1 Code: NU; COG: COG3166; hypothetical protein 3453102 yrfC 4208204 yrfC Shigella flexneri 5 str. 8401 hypothetical protein YP_690746.1 3452563 R 373384 CDS YP_690747.1 110807227 4207720 complement(3453102..3453881) 1 NC_008258.1 hypothetical protein 3453881 yrfD 4207720 yrfD Shigella flexneri 5 str. 8401 hypothetical protein YP_690747.1 3453102 R 373384 CDS YP_690748.1 110807228 4207721 3454001..3456553 1 NC_008258.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3456553 mrcA 4207721 mrcA Shigella flexneri 5 str. 8401 peptidoglycan synthetase YP_690748.1 3454001 D 373384 CDS YP_690749.1 110807229 4207722 complement(3456718..3457278) 1 NC_008258.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3457278 nudE 4207722 nudE Shigella flexneri 5 str. 8401 ADP-ribose diphosphatase NudE YP_690749.1 3456718 R 373384 CDS YP_690750.1 110807230 4207723 3457598..3459733 1 NC_008258.1 dehydrogenase 3459733 yrfF 4207723 yrfF Shigella flexneri 5 str. 8401 dehydrogenase YP_690750.1 3457598 D 373384 CDS YP_690751.1 110807231 4207724 3459798..3460499 1 NC_008258.1 Code: R; COG: COG1011; phosphatase 3460499 yrfG 4207724 yrfG Shigella flexneri 5 str. 8401 phosphatase YP_690751.1 3459798 D 373384 CDS YP_690752.1 110807232 4207725 3460477..3460878 1 NC_008258.1 Code: J; COG: COG1188; ribosome-associated heat shock protein Hsp15 3460878 yrfH 4207725 yrfH Shigella flexneri 5 str. 8401 ribosome-associated heat shock protein Hsp15 YP_690752.1 3460477 D 373384 CDS YP_690753.1 110807233 4207726 3460903..3461772 1 NC_008258.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; heat shock protein 33 3461772 hslO 4207726 hslO Shigella flexneri 5 str. 8401 heat shock protein 33 YP_690753.1 3460903 D 373384 CDS YP_690754.1 110807234 4207727 complement(3461916..3463601) 1 NC_008258.1 transport protein 3463601 yhgE 4207727 yhgE Shigella flexneri 5 str. 8401 transport protein YP_690754.1 3461916 R 373384 CDS YP_690755.1 110807235 4207728 3464019..3465641 1 NC_008258.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3465641 pckA 4207728 pckA Shigella flexneri 5 str. 8401 phosphoenolpyruvate carboxykinase YP_690755.1 3464019 D 373384 CDS YP_690756.1 110807236 4207729 complement(3465717..3467069) 1 NC_008258.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3467069 envZ 4207729 envZ Shigella flexneri 5 str. 8401 osmolarity sensor protein YP_690756.1 3465717 R 373384 CDS YP_690757.1 110807237 4207730 complement(3467066..3467785) 1 NC_008258.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3467785 ompR 4207730 ompR Shigella flexneri 5 str. 8401 osmolarity response regulator YP_690757.1 3467066 R 373384 CDS YP_690758.1 110807238 4207731 3468013..3468489 1 NC_008258.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3468489 greB 4207731 greB Shigella flexneri 5 str. 8401 transcription elongation factor GreB YP_690758.1 3468013 D 373384 CDS YP_690759.1 110807239 4207732 3468586..3470907 1 NC_008258.1 Code: K; COG: COG2183; hypothetical protein 3470907 yhgF 4207732 yhgF Shigella flexneri 5 str. 8401 hypothetical protein YP_690759.1 3468586 D 373384 CDS YP_690760.1 110807240 4207733 3471345..3471572 1 NC_008258.1 Code: P; COG: COG1918; ferrous iron transport protein A 3471572 feoA 4207733 feoA Shigella flexneri 5 str. 8401 ferrous iron transport protein A YP_690760.1 3471345 D 373384 CDS YP_690761.1 110807241 4207734 3471589..3473910 1 NC_008258.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3473910 feoB 4207734 feoB Shigella flexneri 5 str. 8401 ferrous iron transport protein B YP_690761.1 3471589 D 373384 CDS YP_690762.1 110807242 4207735 3473901..3474146 1 NC_008258.1 hypothetical protein 3474146 yhgG 4207735 yhgG Shigella flexneri 5 str. 8401 hypothetical protein YP_690762.1 3473901 D 373384 CDS YP_690763.1 110807243 4207736 3474349..3475236 1 NC_008258.1 Code: S; COG: COG5464; hypothetical protein 3475236 yhgA 4207736 yhgA Shigella flexneri 5 str. 8401 hypothetical protein YP_690763.1 3474349 D 373384 CDS YP_690764.1 110807244 4207737 3475312..3475677 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3475677 4207737 SFV_3417 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_690764.1 3475312 D 373384 CDS YP_690765.1 110807245 4207738 3475701..3476540 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 3476540 4207738 SFV_3418 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_690765.1 3475701 D 373384 CDS YP_690766.1 110807246 4207739 3476899..3477264 1 NC_008258.1 Code: T; COG: COG2337; growth inhibitor, PemK-like, autoregulated 3477264 4207739 SFV_3419 Shigella flexneri 5 str. 8401 growth inhibitor, PemK-like, autoregulated YP_690766.1 3476899 D 373384 CDS YP_690767.1 110807247 4210482 complement(3477265..3477972) 1 NC_008258.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3477972 bioH 4210482 bioH Shigella flexneri 5 str. 8401 carboxylesterase BioH YP_690767.1 3477265 R 373384 CDS YP_690768.1 110807248 4210483 3478043..3478774 1 NC_008258.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3478774 yhgH 4210483 yhgH Shigella flexneri 5 str. 8401 gluconate periplasmic binding protein YP_690768.1 3478043 D 373384 CDS YP_690769.1 110807249 4210484 3478833..3479408 1 NC_008258.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 3479408 yhgI 4210484 yhgI Shigella flexneri 5 str. 8401 DNA uptake protein YP_690769.1 3478833 D 373384 CDS YP_690770.1 110807250 4210485 3479769..3481085 1 NC_008258.1 Code: GE; COG: COG2610; high-affinity transport permease for gluconate 3481085 gntT 4210485 gntT Shigella flexneri 5 str. 8401 high-affinity transport permease for gluconate YP_690770.1 3479769 D 373384 CDS YP_690771.1 110807251 4210486 complement(3481130..3483214) 1 NC_008258.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3483214 malQ 4210486 malQ Shigella flexneri 5 str. 8401 4-alpha-glucanotransferase YP_690771.1 3481130 R 373384 CDS YP_690772.1 110807252 4210487 complement(3483224..3485617) 1 NC_008258.1 Code: G; COG: COG0058; maltodextrin phosphorylase 3485617 malP 4210487 malP Shigella flexneri 5 str. 8401 maltodextrin phosphorylase YP_690772.1 3483224 R 373384 CDS YP_690773.1 110807253 4210488 3486229..3488934 1 NC_008258.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3488934 malT 4210488 malT Shigella flexneri 5 str. 8401 transcriptional regulator MalT YP_690773.1 3486229 D 373384 CDS YP_690774.1 110807254 4210489 complement(3488977..3489879) 1 NC_008258.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3489879 yhgKJ 4210489 yhgKJ Shigella flexneri 5 str. 8401 RNA 3'-terminal-phosphate cyclase YP_690774.1 3488977 R 373384 CDS YP_690775.1 110807255 4210490 complement(3489883..3491109) 1 NC_008258.1 Code: S; COG: COG1690; hypothetical protein 3491109 rtcB 4210490 rtcB Shigella flexneri 5 str. 8401 hypothetical protein YP_690775.1 3489883 R 373384 CDS YP_690776.1 110807256 4210491 3491298..3492896 1 NC_008258.1 Code: KT; COG: COG4650; 2-component regulator 3492896 rtcR 4210491 rtcR Shigella flexneri 5 str. 8401 2-component regulator YP_690776.1 3491298 D 373384 CDS YP_690777.1 110807257 4210492 complement(3492878..3493636) 1 NC_008258.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3493636 glpR 4210492 glpR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor GlpR YP_690777.1 3492878 R 373384 CDS YP_690778.1 110807258 4210493 complement(3493653..3494426) 1 NC_008258.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3494426 glpG 4210493 glpG Shigella flexneri 5 str. 8401 intramembrane serine protease GlpG YP_690778.1 3493653 R 373384 CDS YP_690779.1 110807259 4210494 complement(3494528..3494854) 1 NC_008258.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3494854 glpE 4210494 glpE Shigella flexneri 5 str. 8401 thiosulfate sulfurtransferase YP_690779.1 3494528 R 373384 CDS YP_690780.1 110807260 4210495 3495044..3496549 1 NC_008258.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3496549 glpD 4210495 glpD Shigella flexneri 5 str. 8401 glycerol-3-phosphate dehydrogenase YP_690780.1 3495044 D 373384 CDS YP_690781.1 110807261 4210496 complement(3496755..3497036) 1 NC_008258.1 hypothetical protein 3497036 yzgL 4210496 yzgL Shigella flexneri 5 str. 8401 hypothetical protein YP_690781.1 3496755 R 373384 CDS YP_690782.1 110807262 4210497 complement(3497156..3498166) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 3498166 4210497 SFV_3435 Shigella flexneri 5 str. 8401 IS4 orf YP_690782.1 3497156 R 373384 CDS YP_690783.1 110807263 4210498 complement(3498180..3498503) 1 NC_008258.1 IS4 orf 3498503 4210498 SFV_3436 Shigella flexneri 5 str. 8401 IS4 orf YP_690783.1 3498180 R 373384 CDS YP_690784.1 110807264 4210499 complement(3498603..3501050) 1 NC_008258.1 Code: G; COG: COG0058; glycogen phosphorylase 3501050 glgP 4210499 glgP Shigella flexneri 5 str. 8401 glycogen phosphorylase YP_690784.1 3498603 R 373384 CDS YP_690785.1 110807265 4210500 complement(3501069..3502502) 1 NC_008258.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 3502502 glgA 4210500 glgA Shigella flexneri 5 str. 8401 glycogen synthase YP_690785.1 3501069 R 373384 CDS YP_690786.1 110807266 4207644 complement(3502502..3503797) 1 NC_008258.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3503797 glgC 4207644 glgC Shigella flexneri 5 str. 8401 glucose-1-phosphate adenylyltransferase YP_690786.1 3502502 R 373384 CDS YP_690787.1 110807267 4207645 complement(3503815..3505788) 1 NC_008258.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching enzyme 3505788 glgX 4207645 glgX Shigella flexneri 5 str. 8401 glycogen debranching enzyme YP_690787.1 3503815 R 373384 CDS YP_690788.1 110807268 4207646 complement(3505785..3507971) 1 NC_008258.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 3507971 glgB 4207646 glgB Shigella flexneri 5 str. 8401 glycogen branching enzyme YP_690788.1 3505785 R 373384 CDS YP_690789.1 110807269 4207647 complement(3508244..3509347) 1 NC_008258.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3509347 asd 4207647 asd Shigella flexneri 5 str. 8401 aspartate-semialdehyde dehydrogenase YP_690789.1 3508244 R 373384 CDS YP_690790.1 110807270 4207648 3509581..3510132 1 NC_008258.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 3510132 yhgN 4207648 yhgN Shigella flexneri 5 str. 8401 dITP- and XTP- hydrolase YP_690790.1 3509581 D 373384 CDS YP_690791.1 110807271 4207650 complement(3511532..3512059) 1 NC_008258.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 1 3512059 gntK 4207650 gntK Shigella flexneri 5 str. 8401 gluconate kinase 1 YP_690791.1 3511532 R 373384 CDS YP_690792.1 110807272 4207651 complement(3512198..3513136) 1 NC_008258.1 Code: K; COG: COG1609; regulator of gluconate (gnt) operon 3513136 gntR 4207651 gntR Shigella flexneri 5 str. 8401 regulator of gluconate (gnt) operon YP_690792.1 3512198 R 373384 CDS YP_690793.1 110807273 4207652 complement(3513417..3514112) 1 NC_008258.1 Code: R; COG: COG1741; hypothetical protein 3514112 yhhW 4207652 yhhW Shigella flexneri 5 str. 8401 hypothetical protein YP_690793.1 3513417 R 373384 CDS YP_690794.1 110807274 4207653 complement(3514235..3515272) 1 NC_008258.1 Code: R; COG: COG0673; dehydrogenase 3515272 yhhX 4207653 yhhX Shigella flexneri 5 str. 8401 dehydrogenase YP_690794.1 3514235 R 373384 CDS YP_690795.1 110807275 4207654 3515527..3516093 1 NC_008258.1 YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 3516093 yhhY 4207654 yhhY Shigella flexneri 5 str. 8401 acetyltransferase YhhY YP_690795.1 3515527 D 373384 CDS YP_690796.1 110807276 4207655 complement(3516152..3517894) 1 NC_008258.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 3517894 ggt 4207655 ggt Shigella flexneri 5 str. 8401 gamma-glutamyltranspeptidase YP_690796.1 3516152 R 373384 CDS YP_690797.1 110807277 4207656 3518014..3518454 1 NC_008258.1 hypothetical protein 3518454 yhhA 4207656 yhhA Shigella flexneri 5 str. 8401 hypothetical protein YP_690797.1 3518014 D 373384 CDS YP_690798.1 110807278 4207657 complement(3518441..3519184) 1 NC_008258.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; cytoplasmic glycerophosphodiester phosphodiesterase 3519184 ugpQ 4207657 ugpQ Shigella flexneri 5 str. 8401 cytoplasmic glycerophosphodiester phosphodiesterase YP_690798.1 3518441 R 373384 CDS YP_690799.1 110807279 4207659 complement(3520173..3521018) 1 NC_008258.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 3521018 ugpE 4207659 ugpE Shigella flexneri 5 str. 8401 glycerol-3-phosphate transporter membrane protein YP_690799.1 3520173 R 373384 CDS YP_690800.1 110807280 4207660 complement(3521015..3521902) 1 NC_008258.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 3521902 ugpA 4207660 ugpA Shigella flexneri 5 str. 8401 glycerol-3-phosphate transporter permease YP_690800.1 3521015 R 373384 CDS YP_690801.1 110807281 4207661 complement(3522000..3523316) 1 NC_008258.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 3523316 ugpB 4207661 ugpB Shigella flexneri 5 str. 8401 glycerol-3-phosphate transporter periplasmic binding protein YP_690801.1 3522000 R 373384 CDS YP_690802.1 110807282 4207662 complement(3523713..3524426) 1 NC_008258.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3524426 livF 4207662 livF Shigella flexneri 5 str. 8401 leucine/isoleucine/valine transporter ATP-binding subunit YP_690802.1 3523713 R 373384 CDS YP_690803.1 110807283 4207663 complement(3524428..3525195) 1 NC_008258.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3525195 livG 4207663 livG Shigella flexneri 5 str. 8401 leucine/isoleucine/valine transporter ATP-binding subunit YP_690803.1 3524428 R 373384 CDS YP_690804.1 110807284 4209026 complement(3525192..3526400) 1 NC_008258.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 3526400 livM 4209026 livM Shigella flexneri 5 str. 8401 leucine/isoleucine/valine transporter permease subunit YP_690804.1 3525192 R 373384 CDS YP_690805.1 110807285 4209027 complement(3526466..3527359) 1 NC_008258.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 3527359 livH 4209027 livH Shigella flexneri 5 str. 8401 branched-chain amino acid transporter permease subunit LivH YP_690805.1 3526466 R 373384 CDS YP_690806.1 110807286 4209028 complement(3527440..3528555) 1 NC_008258.1 Code: E; COG: COG0683; leucine-specific binding protein 3528555 livK 4209028 livK Shigella flexneri 5 str. 8401 leucine-specific binding protein YP_690806.1 3527440 R 373384 CDS YP_690807.1 110807287 4209029 3528973..3529356 1 NC_008258.1 hypothetical protein 3529356 yhhK 4209029 yhhK Shigella flexneri 5 str. 8401 hypothetical protein YP_690807.1 3528973 D 373384 CDS YP_690808.1 110807288 4209030 complement(3529555..3530658) 1 NC_008258.1 Code: E; COG: COG0683; Leu/Ile/Val-binding protein 3530658 livJ 4209030 livJ Shigella flexneri 5 str. 8401 Leu/Ile/Val-binding protein YP_690808.1 3529555 R 373384 CDS YP_690809.1 110807289 4209031 complement(3530929..3531783) 1 NC_008258.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3531783 rpoH 4209031 rpoH Shigella flexneri 5 str. 8401 RNA polymerase factor sigma-32 YP_690809.1 3530929 R 373384 CDS YP_690810.1 110807290 4209032 complement(3532029..3533087) 1 NC_008258.1 ABC transporter, membrane protein; cell division protein FtsX 3533087 ftsX 4209032 ftsX Shigella flexneri 5 str. 8401 cell division protein FtsX YP_690810.1 3532029 R 373384 CDS YP_690811.1 110807291 4209033 complement(3533080..3533748) 1 NC_008258.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 3533748 ftsE 4209033 ftsE Shigella flexneri 5 str. 8401 cell division protein FtsE YP_690811.1 3533080 R 373384 CDS YP_690812.1 110807292 4209035 3535326..3535922 1 NC_008258.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3535922 rsmD 4209035 rsmD Shigella flexneri 5 str. 8401 16S rRNA m(2)G966-methyltransferase YP_690812.1 3535326 D 373384 CDS YP_690813.1 110807293 4209036 3535912..3536181 1 NC_008258.1 Code: S; COG: COG3776; hypothetical protein 3536181 yhhL 4209036 yhhL Shigella flexneri 5 str. 8401 hypothetical protein YP_690813.1 3535912 D 373384 CDS YP_690814.1 110807294 4209037 complement(3536184..3536543) 1 NC_008258.1 receptor 3536543 yhhM 4209037 yhhM Shigella flexneri 5 str. 8401 receptor YP_690814.1 3536184 R 373384 CDS YP_690815.1 110807295 4209038 3536684..3537310 1 NC_008258.1 Code: S; COG: COG3714; hypothetical protein 3537310 yhhN 4209038 yhhN Shigella flexneri 5 str. 8401 hypothetical protein YP_690815.1 3536684 D 373384 CDS YP_690816.1 110807296 4209039 3537384..3539582 1 NC_008258.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3539582 zntA 4209039 zntA Shigella flexneri 5 str. 8401 zinc/cadmium/mercury/lead-transporting ATPase YP_690816.1 3537384 D 373384 CDS YP_690817.1 110807297 4209040 complement(3539684..3539929) 1 NC_008258.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3539929 yhhP 4209040 yhhP Shigella flexneri 5 str. 8401 sulfur transfer protein SirA YP_690817.1 3539684 R 373384 CDS YP_690818.1 110807298 4209041 3540186..3540815 1 NC_008258.1 Code: S; COG: COG1738; hypothetical protein 3540815 yhhQ 4209041 yhhQ Shigella flexneri 5 str. 8401 hypothetical protein YP_690818.1 3540186 D 373384 CDS YP_690819.1 110807299 4209042 3540888..3541445 1 NC_008258.1 hypothetical protein 3541445 4209042 SFV_3475 Shigella flexneri 5 str. 8401 hypothetical protein YP_690819.1 3540888 D 373384 CDS YP_690820.2 162139326 4209043 complement(3541449..3542666) 1 NC_008258.1 Code: GEPR; COG: COG0477; major facilitator superfamily transporter 3542666 yhhS 4209043 yhhS Shigella flexneri 5 str. 8401 major facilitator superfamily transporter YP_690820.2 3541449 R 373384 CDS YP_690821.1 110807301 4209044 3542800..3543849 1 NC_008258.1 Code: R; COG: COG0628; hypothetical protein 3543849 yhhT 4209044 yhhT Shigella flexneri 5 str. 8401 hypothetical protein YP_690821.1 3542800 D 373384 CDS YP_690822.1 110807302 4210674 3543904..3544491 1 NC_008258.1 Code: H; COG: COG2091; holo-(acyl carrier protein) synthase 2 3544491 yhhU 4210674 yhhU Shigella flexneri 5 str. 8401 holo-(acyl carrier protein) synthase 2 YP_690822.1 3543904 D 373384 CDS YP_690823.1 110807303 4210675 3544602..3546176 1 NC_008258.1 Code: E; COG: COG0747; periplasmic binding protein for nickel 3546176 nikA 4210675 nikA Shigella flexneri 5 str. 8401 periplasmic binding protein for nickel YP_690823.1 3544602 D 373384 CDS YP_690824.1 110807304 4210676 3546176..3547120 1 NC_008258.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3547120 nikB 4210676 nikB Shigella flexneri 5 str. 8401 nickel transporter permease NikB YP_690824.1 3546176 D 373384 CDS YP_690825.1 110807305 4210677 3547117..3547950 1 NC_008258.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3547950 nikC 4210677 nikC Shigella flexneri 5 str. 8401 nickel transporter permease NikC YP_690825.1 3547117 D 373384 CDS YP_690826.1 110807306 4210678 3547950..3548714 1 NC_008258.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3548714 nikD 4210678 nikD Shigella flexneri 5 str. 8401 nickel transporter ATP-binding protein NikD YP_690826.1 3547950 D 373384 CDS YP_690827.1 110807307 4210679 3548711..3549517 1 NC_008258.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3549517 nikE 4210679 nikE Shigella flexneri 5 str. 8401 nickel transporter ATP-binding protein NikE YP_690827.1 3548711 D 373384 CDS YP_690828.1 110807308 4210680 3549523..3549924 1 NC_008258.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3549924 yhhG 4210680 yhhG Shigella flexneri 5 str. 8401 nickel responsive regulator YP_690828.1 3549523 D 373384 CDS YP_690829.1 110807309 4210681 complement(3550044..3550403) 1 NC_008258.1 Code: S; COG: COG4226; hypothetical protein 3550403 hicB 4210681 hicB Shigella flexneri 5 str. 8401 hypothetical protein YP_690829.1 3550044 R 373384 CDS YP_690830.1 110807310 4210682 complement(3550734..3551858) 1 NC_008258.1 Code: V; COG: COG0842; transporter 3551858 yhhJ 4210682 yhhJ Shigella flexneri 5 str. 8401 transporter YP_690830.1 3550734 R 373384 CDS YP_690831.1 110807311 4210683 complement(3551858..3554593) 1 NC_008258.1 ABC transporter ATP-binding protein 3554593 yhiH 4210683 yhiH Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_690831.1 3551858 R 373384 CDS YP_690832.1 110807312 4210684 complement(3554590..3555657) 1 NC_008258.1 Code: M; COG: COG0845; hypothetical protein 3555657 yhiI 4210684 yhiI Shigella flexneri 5 str. 8401 hypothetical protein YP_690832.1 3554590 R 373384 CDS YP_690833.1 110807313 4210685 complement(3556023..3557645) 1 NC_008258.1 hypothetical protein 3557645 yhiJ 4210685 yhiJ Shigella flexneri 5 str. 8401 hypothetical protein YP_690833.1 3556023 R 373384 CDS YP_690834.1 110807314 4210686 complement(3557907..3559682) 1 NC_008258.1 hypothetical protein 3559682 yhiL 4210686 yhiL Shigella flexneri 5 str. 8401 hypothetical protein YP_690834.1 3557907 R 373384 CDS YP_690835.1 110807315 4210687 3559957..3560445 1 NC_008258.1 hypothetical protein 3560445 4210687 SFV_3491 Shigella flexneri 5 str. 8401 hypothetical protein YP_690835.1 3559957 D 373384 CDS YP_690836.1 110807316 4210688 complement(3561468..3562232) 1 NC_008258.1 hypothetical protein 3562232 4210688 SFV_3492 Shigella flexneri 5 str. 8401 hypothetical protein YP_690836.1 3561468 R 373384 CDS YP_690837.1 110807317 4210689 3562511..3563239 1 NC_008258.1 hypothetical protein 3563239 4210689 SFV_3493 Shigella flexneri 5 str. 8401 hypothetical protein YP_690837.1 3562511 D 373384 CDS YP_690838.1 110807318 4210690 complement(3563346..3563858) 1 NC_008258.1 hypothetical protein 3563858 4210690 SFV_3494 Shigella flexneri 5 str. 8401 hypothetical protein YP_690838.1 3563346 R 373384 CDS YP_690839.1 110807319 4210691 complement(3563997..3565145) 1 NC_008258.1 fimbriae usher 3565145 4210691 SFV_3495 Shigella flexneri 5 str. 8401 fimbriae usher YP_690839.1 3563997 R 373384 CDS YP_690840.1 110807320 4210692 3565237..3565602 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3565602 4210692 SFV_3496 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_690840.1 3565237 D 373384 CDS YP_690841.2 162139325 4210693 3565560..3566465 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3566465 4210693 SFV_3497 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_690841.2 3565560 D 373384 CDS YP_690842.1 110807322 4206918 complement(3566720..3567712) 1 NC_008258.1 fimbrial protein remnant 3567712 4206918 SFV_3498 Shigella flexneri 5 str. 8401 fimbrial protein remnant YP_690842.1 3566720 R 373384 CDS YP_690843.1 110807323 4206919 complement(3567843..3568646) 1 NC_008258.1 Code: NU; COG: COG3121; periplasmic fimbrial chaperone protein 3568646 4206919 SFV_3499 Shigella flexneri 5 str. 8401 periplasmic fimbrial chaperone protein YP_690843.1 3567843 R 373384 CDS YP_690844.1 110807324 4206920 complement(3569806..3571080) 1 NC_008258.1 hypothetical protein 3571080 4206920 SFV_3500 Shigella flexneri 5 str. 8401 hypothetical protein YP_690844.1 3569806 R 373384 CDS YP_690845.1 110807325 4206921 3571096..3571395 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 3571395 4206921 SFV_3501 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_690845.1 3571096 D 373384 CDS YP_690846.1 110807326 4206922 complement(3571406..3571801) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3571801 insB 4206922 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690846.1 3571406 R 373384 CDS YP_690847.1 110807327 4206923 3571984..3572226 1 NC_008258.1 IS1 encoded protein 3572226 4206923 SFV_3503 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690847.1 3571984 D 373384 CDS YP_690848.1 110807328 4206924 complement(3572632..3573786) 1 NC_008258.1 Code: R; COG: COG2081; hypothetical protein 3573786 yhiN 4206924 yhiN Shigella flexneri 5 str. 8401 hypothetical protein YP_690848.1 3572632 R 373384 CDS YP_690849.1 110807329 4206925 3574063..3575562 1 NC_008258.1 Code: P; COG: COG0306; inorganic phosphate transporter 3575562 pitA 4206925 pitA Shigella flexneri 5 str. 8401 inorganic phosphate transporter YP_690849.1 3574063 D 373384 CDS YP_690850.1 110807330 4206926 complement(3575633..3575968) 1 NC_008258.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 3575968 yhiO 4206926 yhiO Shigella flexneri 5 str. 8401 universal stress protein UspB YP_690850.1 3575633 R 373384 CDS YP_690851.1 110807331 4206927 3576359..3576793 1 NC_008258.1 Code: T; COG: COG0589; universal stress protein 3576793 uspA 4206927 uspA Shigella flexneri 5 str. 8401 universal stress protein YP_690851.1 3576359 D 373384 CDS YP_690852.1 110807332 4206929 complement(3578629..3579381) 1 NC_008258.1 predicted SAM-dependent methyltransferase; methyltransferase 3579381 yhiQ 4206929 yhiQ Shigella flexneri 5 str. 8401 methyltransferase YP_690852.1 3578629 R 373384 CDS YP_690853.1 110807333 4206930 complement(3579389..3581431) 1 NC_008258.1 Code: E; COG: COG0339; oligopeptidase A 3581431 prlC 4206930 prlC Shigella flexneri 5 str. 8401 oligopeptidase A YP_690853.1 3579389 R 373384 CDS YP_690854.1 110807334 4206931 3581583..3582476 1 NC_008258.1 Code: R; COG: COG2961; hypothetical protein 3582476 yhiR 4206931 yhiR Shigella flexneri 5 str. 8401 hypothetical protein YP_690854.1 3581583 D 373384 CDS YP_690855.1 110807335 4206932 3582548..3583900 1 NC_008258.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 3583900 gor 4206932 gor Shigella flexneri 5 str. 8401 glutathione reductase YP_690855.1 3582548 D 373384 CDS YP_690856.1 110807336 4206933 3584780..3585133 1 NC_008258.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 3585133 arsR 4206933 arsR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor ArsR YP_690856.1 3584780 D 373384 CDS YP_690857.1 110807337 4206934 3585187..3586476 1 NC_008258.1 Code: P; COG: COG1055; arsenical pump membrane protein 3586476 arsB 4206934 arsB Shigella flexneri 5 str. 8401 arsenical pump membrane protein YP_690857.1 3585187 D 373384 CDS YP_690858.1 110807338 4206935 3586489..3586914 1 NC_008258.1 Code: P; COG: COG1393; arsenate reductase 3586914 arsC 4206935 arsC Shigella flexneri 5 str. 8401 arsenate reductase YP_690858.1 3586489 D 373384 CDS YP_690859.1 110807339 4206936 complement(3587413..3587664) 1 NC_008258.1 IS1 encoded protein 3587664 4206936 SFV_3516 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690859.1 3587413 R 373384 CDS YP_690860.1 110807340 4208302 3587739..3588242 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3588242 insB 4208302 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690860.1 3587739 D 373384 CDS YP_690861.1 110807341 4208303 3588267..3589229 1 NC_008258.1 Code: R; COG: COG0701; hypothetical protein 3589229 4208303 SFV_3518 Shigella flexneri 5 str. 8401 hypothetical protein YP_690861.1 3588267 D 373384 CDS YP_690862.1 110807342 4208304 3589810..3591033 1 NC_008258.1 hypothetical protein 3591033 4208304 SFV_3519 Shigella flexneri 5 str. 8401 hypothetical protein YP_690862.1 3589810 D 373384 CDS YP_690863.1 110807343 4208305 3591115..3591846 1 NC_008258.1 Code: M; COG: COG3065; outer membrane protein induced after carbon starvation 3591846 slp 4208305 slp Shigella flexneri 5 str. 8401 outer membrane protein induced after carbon starvation YP_690863.1 3591115 D 373384 CDS YP_690864.1 110807344 4208306 3592002..3592532 1 NC_008258.1 Code: K; COG: COG2771; hypothetical protein 3592532 yhiF 4208306 yhiF Shigella flexneri 5 str. 8401 hypothetical protein YP_690864.1 3592002 D 373384 CDS YP_690865.1 110807345 4208308 complement(3593284..3593610) 1 NC_008258.1 acid-resistance protein 3593610 hdeB 4208308 hdeB Shigella flexneri 5 str. 8401 acid-resistance protein YP_690865.1 3593284 R 373384 CDS YP_690866.1 110807346 4208309 complement(3593726..3594058) 1 NC_008258.1 inactive form; acid-resistance protein 3594058 hdeA 4208309 hdeA Shigella flexneri 5 str. 8401 acid-resistance protein YP_690866.1 3593726 R 373384 CDS YP_690867.1 110807347 4208310 3594313..3594885 1 NC_008258.1 Code: S; COG: COG3247; acid-resistance membrane protein 3594885 hdeD 4208310 hdeD Shigella flexneri 5 str. 8401 acid-resistance membrane protein YP_690867.1 3594313 D 373384 CDS YP_690868.1 110807348 4208311 3595684..3596211 1 NC_008258.1 Code: K; COG: COG2771; hypothetical protein 3596211 yhiE 4208311 yhiE Shigella flexneri 5 str. 8401 hypothetical protein YP_690868.1 3595684 D 373384 CDS YP_690869.1 110807349 4208313 complement(3597608..3598111) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3598111 insB 4208313 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690869.1 3597608 R 373384 CDS YP_690870.1 110807350 4208314 3598225..3598854 1 NC_008258.1 Code: L; COG: COG2963; IS150 ORF1(ORF A) 3598854 4208314 SFV_3529 Shigella flexneri 5 str. 8401 IS150 ORF1(ORF A) YP_690870.1 3598225 D 373384 CDS YP_690871.1 110807351 4208315 3598851..3599702 1 NC_008258.1 Code: L; COG: COG2801; IS150 ORF2 3599702 4208315 SFV_3530 Shigella flexneri 5 str. 8401 IS150 ORF2 YP_690871.1 3598851 D 373384 CDS YP_690872.1 110807352 4208316 complement(3600143..3600355) 1 NC_008258.1 Code: K; COG: COG1278; cold-shock protein 3600355 cspA 4208316 cspA Shigella flexneri 5 str. 8401 cold-shock protein YP_690872.1 3600143 R 373384 CDS YP_690873.1 110807353 4208317 complement(3600636..3600926) 1 NC_008258.1 Code: K; COG: COG2944; transcriptional regulator 3600926 yiaG 4208317 yiaG Shigella flexneri 5 str. 8401 transcriptional regulator YP_690873.1 3600636 R 373384 CDS YP_690874.1 110807354 4208318 3601240..3602070 1 NC_008258.1 hypothetical protein 3602070 yiaF 4208318 yiaF Shigella flexneri 5 str. 8401 hypothetical protein YP_690874.1 3601240 D 373384 CDS YP_690875.1 110807355 4208319 complement(3602120..3603094) 1 NC_008258.1 Code: CHR; COG: COG1052; 2-hydroxyacid dehydrogenase 3603094 yiaE 4208319 yiaE Shigella flexneri 5 str. 8401 2-hydroxyacid dehydrogenase YP_690875.1 3602120 R 373384 CDS YP_690876.1 110807356 4208320 complement(3603198..3603848) 1 NC_008258.1 Code: M; COG: COG2885; outer membrane lipoprotein 3603848 yiaD 4208320 yiaD Shigella flexneri 5 str. 8401 outer membrane lipoprotein YP_690876.1 3603198 R 373384 CDS YP_690877.1 110807357 4208321 3604065..3606344 1 NC_008258.1 Code: C; COG: COG0243; biotin sulfoxide reductase 3606344 bisC 4208321 bisC Shigella flexneri 5 str. 8401 biotin sulfoxide reductase YP_690877.1 3604065 D 373384 CDS YP_690878.1 110807358 4208168 complement(3606313..3606753) 1 NC_008258.1 Code: KR; COG: COG0454; hypothetical protein 3606753 yiaC 4208168 yiaC Shigella flexneri 5 str. 8401 hypothetical protein YP_690878.1 3606313 R 373384 CDS YP_690879.2 162139324 4208170 complement(3606750..3607313) 1 NC_008258.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyl-adenine DNA glycosylase I 3607313 tag 4208170 tag Shigella flexneri 5 str. 8401 3-methyl-adenine DNA glycosylase I YP_690879.2 3606750 R 373384 CDS YP_690880.1 110807359 4208169 3607471..3608169 1 NC_008258.1 Code: N; COG: COG5571; lipase 3608169 yhjY 4208169 yhjY Shigella flexneri 5 str. 8401 lipase YP_690880.1 3607471 D 373384 CDS YP_690881.1 110807361 4208171 3608398..3609606 1 NC_008258.1 Code: GEPR; COG: COG0477; resistance protein 3609606 yhjX 4208171 yhjX Shigella flexneri 5 str. 8401 resistance protein YP_690881.1 3608398 D 373384 CDS YP_690882.1 110807362 4208172 3609930..3611621 1 NC_008258.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 3611621 yhjW 4208172 yhjW Shigella flexneri 5 str. 8401 phosphoethanolamine transferase YP_690882.1 3609930 D 373384 CDS YP_690883.1 110807363 4208174 3612534..3614141 1 NC_008258.1 Code: E; COG: COG0747; dipeptide transport protein 3614141 dppA 4208174 dppA Shigella flexneri 5 str. 8401 dipeptide transport protein YP_690883.1 3612534 D 373384 CDS YP_690884.1 110807364 4208175 3614449..3615468 1 NC_008258.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 3615468 dppB 4208175 dppB Shigella flexneri 5 str. 8401 dipeptide transporter permease DppB YP_690884.1 3614449 D 373384 CDS YP_690885.1 110807365 4208177 3616392..3617375 1 NC_008258.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 3617375 dppD 4208177 dppD Shigella flexneri 5 str. 8401 dipeptide transporter ATP-binding subunit YP_690885.1 3616392 D 373384 CDS YP_690886.1 110807366 4208178 3617372..3618376 1 NC_008258.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 3618376 dppF 4208178 dppF Shigella flexneri 5 str. 8401 dipeptide transporter ATP-binding subunit YP_690886.1 3617372 D 373384 CDS YP_690887.1 110807367 4208179 complement(3618406..3619740) 1 NC_008258.1 Code: E; COG: COG0814; transporter protein 3619740 yhjV 4208179 yhjV Shigella flexneri 5 str. 8401 transporter protein YP_690887.1 3618406 R 373384 CDS YP_690888.1 110807368 4208180 complement(3621313..3622992) 1 NC_008258.1 hypothetical protein 3622992 yhjU 4208180 yhjU Shigella flexneri 5 str. 8401 hypothetical protein YP_690888.1 3621313 R 373384 CDS YP_690889.1 110807369 4208181 complement(3622989..3623180) 1 NC_008258.1 hypothetical protein 3623180 yhjT 4208181 yhjT Shigella flexneri 5 str. 8401 hypothetical protein YP_690889.1 3622989 R 373384 CDS YP_690890.1 110807370 4208182 3624510..3625013 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3625013 insB 4208182 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690890.1 3624510 D 373384 CDS YP_690891.1 110807371 4208184 3625798..3625986 1 NC_008258.1 hypothetical protein 3625986 yhjR 4208184 yhjR Shigella flexneri 5 str. 8401 hypothetical protein YP_690891.1 3625798 D 373384 CDS YP_690892.1 110807372 4208185 3625998..3626750 1 NC_008258.1 Code: D; COG: COG1192; cell division protein 3626750 yhjQ 4208185 yhjQ Shigella flexneri 5 str. 8401 cell division protein YP_690892.1 3625998 D 373384 CDS YP_690893.1 110807373 4207813 3629288..3631714 1 NC_008258.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 3631714 yhjN 4207813 yhjN Shigella flexneri 5 str. 8401 cellulose synthase regulator protein YP_690893.1 3629288 D 373384 CDS YP_690894.1 110807374 4207814 3631721..3632827 1 NC_008258.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 3632827 yhjM 4207814 yhjM Shigella flexneri 5 str. 8401 endo-1,4-D-glucanase YP_690894.1 3631721 D 373384 CDS YP_690895.2 229774931 4207816 3635253..3637208 1 NC_008258.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli; phosphodiesterase 3637208 yhjK 4207816 yhjK Shigella flexneri 5 str. 8401 phosphodiesterase YP_690895.2 3635253 D 373384 CDS YP_690896.1 110807376 4207817 3637393..3638679 1 NC_008258.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 3638679 dctA 4207817 dctA Shigella flexneri 5 str. 8401 C4-dicarboxylate transporter DctA YP_690896.1 3637393 D 373384 CDS YP_690897.1 110807377 4207818 3638900..3640396 1 NC_008258.1 Code: R; COG: COG0612; hypothetical protein 3640396 yhjJ 4207818 yhjJ Shigella flexneri 5 str. 8401 hypothetical protein YP_690897.1 3638900 D 373384 CDS YP_690898.1 110807378 4207819 complement(3640492..3641640) 1 NC_008258.1 Code: G; COG: COG0524; ketodeoxygluconokinase 3641640 kdgK 4207819 kdgK Shigella flexneri 5 str. 8401 ketodeoxygluconokinase YP_690898.1 3640492 R 373384 CDS YP_690899.1 110807379 4207820 3641653..3642420 1 NC_008258.1 in Escherichia coli this protein is involved in flagellar function; diguanylate phosphodiesterase 3642420 yhjH 4207820 yhjH Shigella flexneri 5 str. 8401 diguanylate phosphodiesterase YP_690899.1 3641653 D 373384 CDS YP_690900.1 110807380 4207821 3642490..3644550 1 NC_008258.1 Code: M; COG: COG2982; hypothetical protein 3644550 yhjG 4207821 yhjG Shigella flexneri 5 str. 8401 hypothetical protein YP_690900.1 3642490 D 373384 CDS YP_690901.1 110807381 4207822 complement(3644732..3646054) 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 3646054 yhjE 4207822 yhjE Shigella flexneri 5 str. 8401 transport protein YP_690901.1 3644732 R 373384 CDS YP_690902.1 110807382 4207823 complement(3646465..3647478) 1 NC_008258.1 Code: S; COG: COG1295; hypothetical protein 3647478 yhjD 4207823 yhjD Shigella flexneri 5 str. 8401 hypothetical protein YP_690902.1 3646465 R 373384 CDS YP_690903.1 110807383 4207824 complement(3647527..3648498) 1 NC_008258.1 Code: K; COG: COG0583; LysR family transcriptional regulator 3648498 yhjC 4207824 yhjC Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_690903.1 3647527 R 373384 CDS YP_690904.1 110807384 4207825 3648946..3649548 1 NC_008258.1 Code: TK; COG: COG2197; regulator 3649548 yhjB 4207825 yhjB Shigella flexneri 5 str. 8401 regulator YP_690904.1 3648946 D 373384 CDS YP_690905.1 110807385 4207826 complement(3649564..3650910) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 3650910 4207826 SFV_3569 Shigella flexneri 5 str. 8401 IS4 orf YP_690905.1 3649564 R 373384 CDS YP_690906.1 110807386 4207827 complement(3651037..3652686) 1 NC_008258.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 3652686 treF 4207827 treF Shigella flexneri 5 str. 8401 trehalase YP_690906.1 3651037 R 373384 CDS YP_690907.1 110807387 4207828 complement(3652897..3653076) 1 NC_008258.1 IS1 encoded protein 3653076 4207828 SFV_3571 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690907.1 3652897 R 373384 CDS YP_690908.1 110807388 4207829 3653151..3653654 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3653654 insB 4207829 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690908.1 3653151 D 373384 CDS YP_690909.1 110807389 4207830 complement(3653808..3654077) 1 NC_008258.1 Code: S; COG: COG3152; hypothetical protein 3654077 4207830 SFV_3573 Shigella flexneri 5 str. 8401 hypothetical protein YP_690909.1 3653808 R 373384 CDS YP_690910.1 110807390 4207831 3654178..3654777 1 NC_008258.1 hypothetical protein 3654777 yiiQ 4207831 yiiQ Shigella flexneri 5 str. 8401 hypothetical protein YP_690910.1 3654178 D 373384 CDS YP_690911.1 110807391 4207528 3654885..3655652 1 NC_008258.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 3655652 tpiA 4207528 tpiA Shigella flexneri 5 str. 8401 triosephosphate isomerase YP_690911.1 3654885 D 373384 CDS YP_690912.1 110807392 4207529 complement(3655707..3656654) 1 NC_008258.1 Code: I; COG: COG2134; CDP-diacylglycerol pyrophosphatase 3656654 cdh 4207529 cdh Shigella flexneri 5 str. 8401 CDP-diacylglycerol pyrophosphatase YP_690912.1 3655707 R 373384 CDS YP_690913.1 110807393 4207530 complement(3656569..3657558) 1 NC_008258.1 Code: P; COG: COG1613; sulfate transporter subunit 3657558 sbp 4207530 sbp Shigella flexneri 5 str. 8401 sulfate transporter subunit YP_690913.1 3656569 R 373384 CDS YP_690914.1 110807394 4207531 complement(3657878..3658900) 1 NC_008258.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 3658900 pfkA 4207531 pfkA Shigella flexneri 5 str. 8401 6-phosphofructokinase YP_690914.1 3657878 R 373384 CDS YP_690915.1 110807395 4207532 complement(3659021..3659923) 1 NC_008258.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 3659923 fieF 4207532 fieF Shigella flexneri 5 str. 8401 ferrous iron efflux protein F YP_690915.1 3659021 R 373384 CDS YP_690916.1 110807396 4207533 complement(3660071..3660571) 1 NC_008258.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; periplasmic repressor CpxP 3660571 cpxP 4207533 cpxP Shigella flexneri 5 str. 8401 periplasmic repressor CpxP YP_690916.1 3660071 R 373384 CDS YP_690917.1 110807397 4207534 3660787..3661419 1 NC_008258.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 3661419 cpxR 4207534 cpxR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator CpxR YP_690917.1 3660787 D 373384 CDS YP_690918.1 110807398 4207535 3661416..3662789 1 NC_008258.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 3662789 cpxA 4207535 cpxA Shigella flexneri 5 str. 8401 two-component sensor protein YP_690918.1 3661416 D 373384 CDS YP_690919.1 110807399 4207536 complement(3662895..3663569) 1 NC_008258.1 Code: S; COG: COG2258; hypothetical protein 3663569 yiiM 4207536 yiiM Shigella flexneri 5 str. 8401 hypothetical protein YP_690919.1 3662895 R 373384 CDS YP_690920.1 110807400 4207537 3663796..3664161 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3664161 4207537 SFV_3584 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_690920.1 3663796 D 373384 CDS YP_690921.1 110807401 4207538 3664185..3665024 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 3665024 4207538 SFV_3585 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_690921.1 3664185 D 373384 CDS YP_690922.2 162139323 4207539 complement(3665054..3666037) 1 NC_008258.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 3666037 kdgT 4207539 kdgT Shigella flexneri 5 str. 8401 2-keto-3-deoxygluconate permease YP_690922.2 3665054 R 373384 CDS YP_690923.1 110807403 4207540 complement(3666296..3666916) 1 NC_008258.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 3666916 sodA 4207540 sodA Shigella flexneri 5 str. 8401 superoxide dismutase YP_690923.1 3666296 R 373384 CDS YP_690924.1 110807404 4207542 complement(3668400..3669191) 1 NC_008258.1 Code: K; COG: COG2207; positive regulator for rhaRS operon 3669191 rhaR 4207542 rhaR Shigella flexneri 5 str. 8401 positive regulator for rhaRS operon YP_690924.1 3668400 R 373384 CDS YP_690925.1 110807405 4207543 complement(3669154..3669990) 1 NC_008258.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 3669990 rhaS 4207543 rhaS Shigella flexneri 5 str. 8401 transcriptional activator RhaS YP_690925.1 3669154 R 373384 CDS YP_690926.1 110807406 4207544 3670278..3671747 1 NC_008258.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 3671747 rhaB 4207544 rhaB Shigella flexneri 5 str. 8401 rhamnulokinase YP_690926.1 3670278 D 373384 CDS YP_690927.1 110807407 4207545 3671744..3673003 1 NC_008258.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 3673003 rhaA 4207545 rhaA Shigella flexneri 5 str. 8401 L-rhamnose isomerase YP_690927.1 3671744 D 373384 CDS YP_690928.1 110807408 4207546 3673428..3674069 1 NC_008258.1 Code: G; COG: COG0235; rhamnulose-1-phosphate aldolase 3674069 rhaD 4207546 rhaD Shigella flexneri 5 str. 8401 rhamnulose-1-phosphate aldolase YP_690928.1 3673428 D 373384 CDS YP_690929.1 110807409 4208362 3674079..3674393 1 NC_008258.1 Code: S; COG: COG3254; hypothetical protein 3674393 yiiL 4208362 yiiL Shigella flexneri 5 str. 8401 hypothetical protein YP_690929.1 3674079 D 373384 CDS YP_690930.1 110807410 4208363 3674694..3675140 1 NC_008258.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 3675140 frvA 4208363 frvA Shigella flexneri 5 str. 8401 fructose-like phosphotransferase system subunit EIIA YP_690930.1 3674694 D 373384 CDS YP_690931.1 110807411 4208364 3675151..3676602 1 NC_008258.1 Code: G; COG: COG1299; PTS system transporter subunits IIBC 3676602 frvB 4208364 frvB Shigella flexneri 5 str. 8401 PTS system transporter subunits IIBC YP_690931.1 3675151 D 373384 CDS YP_690932.1 110807412 4208365 3676592..3677662 1 NC_008258.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 3677662 frvX 4208365 frvX Shigella flexneri 5 str. 8401 fructose-specific phosphotransferase system protein FrvX YP_690932.1 3676592 D 373384 CDS YP_690933.1 110807413 4208366 3677662..3678312 1 NC_008258.1 frv operon regulatory protein 3678312 frvR 4208366 frvR Shigella flexneri 5 str. 8401 frv operon regulatory protein YP_690933.1 3677662 D 373384 CDS YP_690934.1 110807414 4208367 3678540..3679043 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3679043 insB 4208367 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690934.1 3678540 D 373384 CDS YP_690935.1 110807415 4208368 complement(3679115..3679948) 1 NC_008258.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 3679948 fdhD 4208368 fdhD Shigella flexneri 5 str. 8401 formate dehydrogenase accessory protein YP_690935.1 3679115 R 373384 CDS YP_690936.1 110807416 4208369 3680142..3683192 1 NC_008258.1 Code: C; COG: COG0243; formate dehydrogenase-O, major subunit 3683192 fdoG 4208369 fdoG Shigella flexneri 5 str. 8401 formate dehydrogenase-O, major subunit YP_690936.1 3680142 D 373384 CDS YP_690937.1 110807417 4208370 3683205..3684107 1 NC_008258.1 Code: C; COG: COG0437; formate dehydrogenase-O, iron-sulfur subunit 3684107 fdoH 4208370 fdoH Shigella flexneri 5 str. 8401 formate dehydrogenase-O, iron-sulfur subunit YP_690937.1 3683205 D 373384 CDS YP_690938.1 110807418 4208371 3684104..3684739 1 NC_008258.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 3684739 fdoI 4208371 fdoI Shigella flexneri 5 str. 8401 formate dehydrogenase-O subunit gamma YP_690938.1 3684104 D 373384 CDS YP_690939.1 110807419 4208372 3684736..3685665 1 NC_008258.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 3685665 fdhE 4208372 fdhE Shigella flexneri 5 str. 8401 formate dehydrogenase accessory protein FdhE YP_690939.1 3684736 D 373384 CDS YP_690940.1 110807420 4208373 complement(3685995..3686237) 1 NC_008258.1 hypothetical protein 3686237 yiiF 4208373 yiiF Shigella flexneri 5 str. 8401 hypothetical protein YP_690940.1 3685995 R 373384 CDS YP_690941.1 110807421 4208374 complement(3686455..3686817) 1 NC_008258.1 hypothetical protein 3686817 yiiE 4208374 yiiE Shigella flexneri 5 str. 8401 hypothetical protein YP_690941.1 3686455 R 373384 CDS YP_690942.1 110807422 4208375 complement(3687352..3688674) 1 NC_008258.1 hypothetical protein 3688674 4208375 SFV_3607 Shigella flexneri 5 str. 8401 hypothetical protein YP_690942.1 3687352 R 373384 CDS YP_690943.1 110807423 4208376 complement(3688655..3688993) 1 NC_008258.1 hypothetical protein 3688993 4208376 SFV_3608 Shigella flexneri 5 str. 8401 hypothetical protein YP_690943.1 3688655 R 373384 CDS YP_690944.1 110807424 4208377 complement(3688983..3689171) 1 NC_008258.1 IS1 encoded protein 3689171 4208377 SFV_3609 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_690944.1 3688983 R 373384 CDS YP_690945.1 110807425 4208378 3689246..3689749 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3689749 insB 4208378 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690945.1 3689246 D 373384 CDS YP_690946.1 110807426 4208379 complement(3690360..3691301) 1 NC_008258.1 Code: KR; COG: COG0454; acetyltransferase 3691301 yiiD 4208379 yiiD Shigella flexneri 5 str. 8401 acetyltransferase YP_690946.1 3690360 R 373384 CDS YP_690947.1 110807427 4208380 complement(3691346..3691783) 1 NC_008258.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 3691783 yihZ 4208380 yihZ Shigella flexneri 5 str. 8401 D-tyrosyl-tRNA(Tyr) deacylase YP_690947.1 3691346 R 373384 CDS YP_690948.1 110807428 4208381 complement(3691780..3692652) 1 NC_008258.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 3692652 rbn 4208381 rbn Shigella flexneri 5 str. 8401 ribonuclease BN YP_690948.1 3691780 R 373384 CDS YP_690949.1 110807429 4208616 complement(3692646..3693245) 1 NC_008258.1 Code: R; COG: COG1011; phosphatase 3693245 yihX 4208616 yihX Shigella flexneri 5 str. 8401 phosphatase YP_690949.1 3692646 R 373384 CDS YP_690950.1 110807430 4208617 complement(3693344..3694129) 1 NC_008258.1 Code: KG; COG: COG1349; DeoR-type transcriptional regulator 3694129 yihW 4208617 yihW Shigella flexneri 5 str. 8401 DeoR-type transcriptional regulator YP_690950.1 3693344 R 373384 CDS YP_690951.1 110807431 4208618 complement(3694163..3695059) 1 NC_008258.1 Code: G; COG: COG0524; kinase 3695059 yihV 4208618 yihV Shigella flexneri 5 str. 8401 kinase YP_690951.1 3694163 R 373384 CDS YP_690952.1 110807432 4208619 3695227..3696123 1 NC_008258.1 Code: I; COG: COG2084; dehydrogenase 3696123 yihU 4208619 yihU Shigella flexneri 5 str. 8401 dehydrogenase YP_690952.1 3695227 D 373384 CDS YP_690953.1 110807433 4208620 3696147..3697025 1 NC_008258.1 Code: G; COG: COG3684; aldolase 3697025 yihT 4208620 yihT Shigella flexneri 5 str. 8401 aldolase YP_690953.1 3696147 D 373384 CDS YP_690954.1 110807434 4208621 3697042..3698283 1 NC_008258.1 Code: G; COG: COG2942; hypothetical protein 3698283 yihS 4208621 yihS Shigella flexneri 5 str. 8401 hypothetical protein YP_690954.1 3697042 D 373384 CDS YP_690955.1 110807435 4208622 3698397..3699323 1 NC_008258.1 Code: G; COG: COG2017; aldose-1-epimerase 3699323 yihR 4208622 yihR Shigella flexneri 5 str. 8401 aldose-1-epimerase YP_690955.1 3698397 D 373384 CDS YP_690956.1 110807436 4208623 3699522..3701558 1 NC_008258.1 Code: G; COG: COG1501; alpha-glucosidase 3701558 yihQ 4208623 yihQ Shigella flexneri 5 str. 8401 alpha-glucosidase YP_690956.1 3699522 D 373384 CDS YP_690957.1 110807437 4208624 3701604..3702989 1 NC_008258.1 Code: G; COG: COG2211; permease 3702989 yihP 4208624 yihP Shigella flexneri 5 str. 8401 permease YP_690957.1 3701604 D 373384 CDS YP_690958.1 110807438 4208625 3703032..3704489 1 NC_008258.1 Code: G; COG: COG2211; permease 3704489 yihO 4208625 yihO Shigella flexneri 5 str. 8401 permease YP_690958.1 3703032 D 373384 CDS YP_690959.1 110807439 4208626 3704468..3704854 1 NC_008258.1 hypothetical protein 3704854 4208626 SFV_3624 Shigella flexneri 5 str. 8401 hypothetical protein YP_690959.1 3704468 D 373384 CDS YP_690960.1 110807440 4208627 complement(3704848..3705351) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3705351 insB 4208627 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690960.1 3704848 R 373384 CDS YP_690961.1 110807441 4208628 complement(3705574..3706632) 1 NC_008258.1 Code: GEPR; COG: COG0477; resistance protein 3706632 yihN 4208628 yihN Shigella flexneri 5 str. 8401 resistance protein YP_690961.1 3705574 R 373384 CDS YP_690962.1 110807442 4208629 complement(3706734..3707714) 1 NC_008258.1 hypothetical protein 3707714 yihM 4208629 yihM Shigella flexneri 5 str. 8401 hypothetical protein YP_690962.1 3706734 R 373384 CDS YP_690963.1 110807443 4208630 complement(3707722..3708432) 1 NC_008258.1 Code: K; COG: COG2188; transcriptional regulator 3708432 yihL 4208630 yihL Shigella flexneri 5 str. 8401 transcriptional regulator YP_690963.1 3707722 R 373384 CDS YP_690964.1 110807444 4208631 3708689..3710035 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 3710035 4208631 SFV_3629 Shigella flexneri 5 str. 8401 IS4 orf YP_690964.1 3708689 D 373384 CDS YP_690965.1 110807445 4208632 complement(3710087..3711784) 1 NC_008258.1 Code: T; COG: COG1217; GTP-binding factor 3711784 yihK 4208632 yihK Shigella flexneri 5 str. 8401 GTP-binding factor YP_690965.1 3710087 R 373384 CDS YP_690966.1 110807446 4208633 3712283..3713692 1 NC_008258.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 3713692 glnA 4208633 glnA Shigella flexneri 5 str. 8401 glutamine synthetase YP_690966.1 3712283 D 373384 CDS YP_690967.1 110807447 4208634 3713865..3714914 1 NC_008258.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 3714914 glnL 4208634 glnL Shigella flexneri 5 str. 8401 nitrogen regulation protein NR(II) YP_690967.1 3713865 D 373384 CDS YP_690968.1 110807448 4208990 3714926..3716335 1 NC_008258.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 3716335 glnG 4208990 glnG Shigella flexneri 5 str. 8401 nitrogen regulation protein NR(I) YP_690968.1 3714926 D 373384 CDS YP_690969.1 110807449 4208991 complement(3716785..3718158) 1 NC_008258.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3718158 hemN 4208991 hemN Shigella flexneri 5 str. 8401 coproporphyrinogen III oxidase YP_690969.1 3716785 R 373384 CDS YP_690970.1 110807450 4208992 complement(3718347..3718919) 1 NC_008258.1 Code: S; COG: COG3078; hypothetical protein 3718919 yihI 4208992 yihI Shigella flexneri 5 str. 8401 hypothetical protein YP_690970.1 3718347 R 373384 CDS YP_690971.1 110807451 4208993 3719474..3720070 1 NC_008258.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 3720070 engB 4208993 engB Shigella flexneri 5 str. 8401 ribosome biogenesis GTP-binding protein YsxC YP_690971.1 3719474 D 373384 CDS YP_690972.1 110807452 4208994 complement(3720452..3723238) 1 NC_008258.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 3723238 polA 4208994 polA Shigella flexneri 5 str. 8401 DNA polymerase I YP_690972.1 3720452 R 373384 CDS YP_690973.2 229774930 4208995 3723602..3724534 1 NC_008258.1 Code: I; COG: COG0204; acyltransferase 3724534 yihG 4208995 yihG Shigella flexneri 5 str. 8401 acyltransferase YP_690973.2 3723602 D 373384 CDS YP_690974.1 110807454 4208996 complement(3725335..3725838) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3725838 insB 4208996 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_690974.1 3725335 R 373384 CDS YP_690975.1 110807455 4208998 complement(3726936..3727562) 1 NC_008258.1 Code: OC; COG: COG0526; periplasmic protein disulfide isomerase I 3727562 dsbA 4208998 dsbA Shigella flexneri 5 str. 8401 periplasmic protein disulfide isomerase I YP_690975.1 3726936 R 373384 CDS YP_690976.1 110807456 4208999 complement(3727579..3728487) 1 NC_008258.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 3728487 yihE 4208999 yihE Shigella flexneri 5 str. 8401 serine/threonine protein kinase YP_690976.1 3727579 R 373384 CDS YP_690977.1 110807457 4209000 complement(3728642..3728911) 1 NC_008258.1 Code: S; COG: COG3084; hypothetical protein 3728911 yihD 4209000 yihD Shigella flexneri 5 str. 8401 hypothetical protein YP_690977.1 3728642 R 373384 CDS YP_690978.1 110807458 4209001 3728990..3729565 1 NC_008258.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 3729565 mobA 4209001 mobA Shigella flexneri 5 str. 8401 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_690978.1 3728990 D 373384 CDS YP_690979.1 110807459 4209002 3729547..3730074 1 NC_008258.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 3730074 mobB 4209002 mobB Shigella flexneri 5 str. 8401 molybdopterin-guanine dinucleotide biosynthesis protein B YP_690979.1 3729547 D 373384 CDS YP_690980.1 110807460 4207978 complement(3735564..3736109) 1 NC_008258.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 3736109 hemG 4207978 hemG Shigella flexneri 5 str. 8401 protoporphyrinogen oxidase YP_690980.1 3735564 R 373384 CDS YP_690981.1 110807461 4207979 complement(3736121..3737572) 1 NC_008258.1 Code: P; COG: COG0168; potassium transporter 3737572 trkH 4207979 trkH Shigella flexneri 5 str. 8401 potassium transporter YP_690981.1 3736121 R 373384 CDS YP_690982.1 110807462 4207980 complement(3737611..3738228) 1 NC_008258.1 Code: S; COG: COG1739; hypothetical protein 3738228 yigZ 4207980 yigZ Shigella flexneri 5 str. 8401 hypothetical protein YP_690982.1 3737611 R 373384 CDS YP_690983.1 110807463 4207981 complement(3738225..3739556) 1 NC_008258.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 3739556 pepQ 4207981 pepQ Shigella flexneri 5 str. 8401 proline dipeptidase YP_690983.1 3738225 R 373384 CDS YP_690984.1 110807464 4207982 3739746..3741935 1 NC_008258.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 3741935 fadB 4207982 fadB Shigella flexneri 5 str. 8401 multifunctional fatty acid oxidation complex subunit alpha YP_690984.1 3739746 D 373384 CDS YP_690985.1 110807465 4207983 3741945..3743108 1 NC_008258.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 3743108 fadA 4207983 fadA Shigella flexneri 5 str. 8401 3-ketoacyl-CoA thiolase YP_690985.1 3741945 D 373384 CDS YP_690986.1 110807466 4207984 complement(3743300..3744034) 1 NC_008258.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 3744034 fre 4207984 fre Shigella flexneri 5 str. 8401 FMN reductase YP_690986.1 3743300 R 373384 CDS YP_690987.1 110807467 4207985 complement(3744047..3745540) 1 NC_008258.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 3745540 yigC 4207985 yigC Shigella flexneri 5 str. 8401 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_690987.1 3744047 R 373384 CDS YP_690988.1 110807468 4207986 3745707..3746195 1 NC_008258.1 Code: K; COG: COG0250; transcriptional activator RfaH 3746195 rfaH 4207986 rfaH Shigella flexneri 5 str. 8401 transcriptional activator RfaH YP_690988.1 3745707 D 373384 CDS YP_690989.1 110807469 4207987 complement(3746192..3746974) 1 NC_008258.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 3746974 tatD 4207987 tatD Shigella flexneri 5 str. 8401 DNase TatD YP_690989.1 3746192 R 373384 CDS YP_690990.1 110807470 4207988 complement(3747016..3747792) 1 NC_008258.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 3747792 yigU 4207988 yigU Shigella flexneri 5 str. 8401 twin-arginine protein translocation system subunit TatC YP_690990.1 3747016 R 373384 CDS YP_690991.1 110807471 4207989 complement(3747795..3748310) 1 NC_008258.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 3748310 4207989 SFV_3661 Shigella flexneri 5 str. 8401 sec-independent translocase YP_690991.1 3747795 R 373384 CDS YP_690992.1 110807472 4207990 complement(3748314..3748625) 1 NC_008258.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin-arginine translocation protein TatA 3748625 tatA 4207990 tatA Shigella flexneri 5 str. 8401 twin-arginine translocation protein TatA YP_690992.1 3748314 R 373384 CDS YP_690993.1 110807473 4207991 complement(3748662..3750302) 1 NC_008258.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 3750302 ubiB 4207991 ubiB Shigella flexneri 5 str. 8401 ubiquinone biosynthesis protein UbiB YP_690993.1 3748662 R 373384 CDS YP_690994.1 110807474 4207992 complement(3750299..3750904) 1 NC_008258.1 Code: S; COG: COG3165; hypothetical protein 3750904 yigP 4207992 yigP Shigella flexneri 5 str. 8401 hypothetical protein YP_690994.1 3750299 R 373384 CDS YP_690995.1 110807475 4207993 complement(3750918..3751673) 1 NC_008258.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 3751673 ubiE 4207993 ubiE Shigella flexneri 5 str. 8401 ubiquinone/menaquinone biosynthesis methyltransferase YP_690995.1 3750918 R 373384 CDS YP_690996.1 110807476 4207994 complement(3751768..3753195) 1 NC_008258.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 3753195 yigN 4207994 yigN Shigella flexneri 5 str. 8401 DNA recombination protein RmuC YP_690996.1 3751768 R 373384 CDS YP_690997.1 110807477 4207995 complement(3753336..3754097) 1 NC_008258.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 3754097 udp 4207995 udp Shigella flexneri 5 str. 8401 uridine phosphorylase YP_690997.1 3753336 R 373384 CDS YP_690998.1 110807478 4207996 3754482..3755174 1 NC_008258.1 Code: Q; COG: COG0412; hydrolase 3755174 ysgA 4207996 ysgA Shigella flexneri 5 str. 8401 hydrolase YP_690998.1 3754482 D 373384 CDS YP_690999.1 110807479 4207907 complement(3755213..3757474) 1 NC_008258.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 3757474 metE 4207907 metE Shigella flexneri 5 str. 8401 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_690999.1 3755213 R 373384 CDS YP_691000.1 110807480 4207908 3757710..3758663 1 NC_008258.1 Code: K; COG: COG0583; regulator for metE and metH 3758663 metR 4207908 metR Shigella flexneri 5 str. 8401 regulator for metE and metH YP_691000.1 3757710 D 373384 CDS YP_691001.1 110807481 4207909 complement(3758551..3759450) 1 NC_008258.1 Code: GER; COG: COG0697; hypothetical protein 3759450 yigM 4207909 yigM Shigella flexneri 5 str. 8401 hypothetical protein YP_691001.1 3758551 R 373384 CDS YP_691002.1 110807482 4207910 complement(3759526..3760389) 1 NC_008258.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 3760389 yigL 4207910 yigL Shigella flexneri 5 str. 8401 sugar phosphatase YP_691002.1 3759526 R 373384 CDS YP_691003.1 110807483 4207911 complement(3760334..3761299) 1 NC_008258.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 3761299 pldB 4207911 pldB Shigella flexneri 5 str. 8401 lysophospholipase L2 YP_691003.1 3760334 R 373384 CDS YP_691004.1 110807484 4207912 3761467..3762087 1 NC_008258.1 Code: E; COG: COG1280; homoserine/homoserine lactone efflux protein 3762087 rhtB 4207912 rhtB Shigella flexneri 5 str. 8401 homoserine/homoserine lactone efflux protein YP_691004.1 3761467 D 373384 CDS YP_691005.1 110807485 4207913 complement(3762149..3762769) 1 NC_008258.1 Code: E; COG: COG1280; threonine efflux system 3762769 yigJ 4207913 yigJ Shigella flexneri 5 str. 8401 threonine efflux system YP_691005.1 3762149 R 373384 CDS YP_691006.1 110807486 4207914 complement(3762833..3764662) 1 NC_008258.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 3764662 recQ 4207914 recQ Shigella flexneri 5 str. 8401 ATP-dependent DNA helicase RecQ YP_691006.1 3762833 R 373384 CDS YP_691007.1 110807487 4207915 complement(3764795..3765664) 1 NC_008258.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 3765664 pldA 4207915 pldA Shigella flexneri 5 str. 8401 phospholipase A YP_691007.1 3764795 R 373384 CDS YP_691008.1 110807488 4207916 3765811..3766296 1 NC_008258.1 Code: Q; COG: COG2050; hypothetical protein 3766296 yigI 4207916 yigI Shigella flexneri 5 str. 8401 hypothetical protein YP_691008.1 3765811 D 373384 CDS YP_691009.1 110807489 4207917 3766348..3767238 1 NC_008258.1 Code: R; COG: COG2962; hypothetical protein 3767238 rarD 4207917 rarD Shigella flexneri 5 str. 8401 hypothetical protein YP_691009.1 3766348 D 373384 CDS YP_691010.1 110807490 4207918 3767297..3767707 1 NC_008258.1 hypothetical protein 3767707 yigG 4207918 yigG Shigella flexneri 5 str. 8401 hypothetical protein YP_691010.1 3767297 D 373384 CDS YP_691011.1 110807491 4207919 3767721..3768101 1 NC_008258.1 hypothetical protein 3768101 yigF 4207919 yigF Shigella flexneri 5 str. 8401 hypothetical protein YP_691011.1 3767721 D 373384 CDS YP_691012.1 110807492 4207920 complement(3768142..3769092) 1 NC_008258.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 3769092 corA 4207920 corA Shigella flexneri 5 str. 8401 magnesium/nickel/cobalt transporter CorA YP_691012.1 3768142 R 373384 CDS YP_691013.1 110807493 4207921 3769462..3769800 1 NC_008258.1 hypothetical protein 3769800 yigE 4207921 yigE Shigella flexneri 5 str. 8401 hypothetical protein YP_691013.1 3769462 D 373384 CDS YP_691014.1 110807494 4207922 complement(3769811..3771157) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 3771157 4207922 SFV_3684 Shigella flexneri 5 str. 8401 IS4 orf YP_691014.1 3769811 R 373384 CDS YP_691015.1 110807495 4207923 3771233..3771664 1 NC_008258.1 hypothetical protein 3771664 4207923 SFV_3685 Shigella flexneri 5 str. 8401 hypothetical protein YP_691015.1 3771233 D 373384 CDS YP_691016.1 110807496 4207924 complement(3771812..3773974) 1 NC_008258.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 3773974 uvrD 4207924 uvrD Shigella flexneri 5 str. 8401 DNA-dependent helicase II YP_691016.1 3771812 R 373384 CDS YP_691017.1 110807497 4207925 complement(3774058..3774774) 1 NC_008258.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 3774774 yigB 4207925 yigB Shigella flexneri 5 str. 8401 flavin mononucleotide phosphatase YP_691017.1 3774058 R 373384 CDS YP_691018.1 110807498 4210230 complement(3774774..3775670) 1 NC_008258.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 3775670 xerC 4210230 xerC Shigella flexneri 5 str. 8401 site-specific tyrosine recombinase XerC YP_691018.1 3774774 R 373384 CDS YP_691019.1 110807499 4210231 complement(3775667..3776374) 1 NC_008258.1 Code: S; COG: COG3159; hypothetical protein 3776374 yigA 4210231 yigA Shigella flexneri 5 str. 8401 hypothetical protein YP_691019.1 3775667 R 373384 CDS YP_691020.1 110807500 4210232 complement(3776371..3777195) 1 NC_008258.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3777195 dapF 4210232 dapF Shigella flexneri 5 str. 8401 diaminopimelate epimerase YP_691020.1 3776371 R 373384 CDS YP_691021.1 110807501 4210233 complement(3777232..3777435) 1 NC_008258.1 Code: N; COG: COG5567; outer membrane lipoprotein 3777435 yifL 4210233 yifL Shigella flexneri 5 str. 8401 outer membrane lipoprotein YP_691021.1 3777232 R 373384 CDS YP_691022.1 110807502 4210234 3777624..3778775 1 NC_008258.1 hypothetical protein 3778775 4210234 SFV_3692 Shigella flexneri 5 str. 8401 hypothetical protein YP_691022.1 3777624 D 373384 CDS YP_691023.1 110807503 4210235 3778797..3779102 1 NC_008258.1 hypothetical protein 3779102 4210235 SFV_3693 Shigella flexneri 5 str. 8401 hypothetical protein YP_691023.1 3778797 D 373384 CDS YP_691024.1 110807504 4210236 3779446..3780408 1 NC_008258.1 hypothetical protein 3780408 4210236 SFV_3694 Shigella flexneri 5 str. 8401 hypothetical protein YP_691024.1 3779446 D 373384 CDS YP_691025.1 110807505 4210237 3780456..3780776 1 NC_008258.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 3780776 cyaY 4210237 cyaY Shigella flexneri 5 str. 8401 frataxin-like protein YP_691025.1 3780456 D 373384 CDS YP_691026.1 110807506 4210238 complement(3780816..3783362) 1 NC_008258.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 3783362 cyaA 4210238 cyaA Shigella flexneri 5 str. 8401 adenylate cyclase YP_691026.1 3780816 R 373384 CDS YP_691027.1 110807507 4210239 3783728..3784690 1 NC_008258.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 3784690 hemC 4210239 hemC Shigella flexneri 5 str. 8401 porphobilinogen deaminase YP_691027.1 3783728 D 373384 CDS YP_691028.1 110807508 4210240 3784687..3785427 1 NC_008258.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 3785427 hemD 4210240 hemD Shigella flexneri 5 str. 8401 uroporphyrinogen-III synthase YP_691028.1 3784687 D 373384 CDS YP_691029.1 110807509 4210241 3785449..3786666 1 NC_008258.1 Code: H; COG: COG2959; uroporphyrinogen III C-methyltransferase 3786666 hemX 4210241 hemX Shigella flexneri 5 str. 8401 uroporphyrinogen III C-methyltransferase YP_691029.1 3785449 D 373384 CDS YP_691030.1 110807510 4210242 3786669..3787865 1 NC_008258.1 Code: H; COG: COG3071; protoheme IX biogenesis protein 3787865 hemY 4210242 hemY Shigella flexneri 5 str. 8401 protoheme IX biogenesis protein YP_691030.1 3786669 D 373384 CDS YP_691031.1 110807511 4210243 3788727..3789092 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3789092 4210243 SFV_3701 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_691031.1 3788727 D 373384 CDS YP_691032.1 110807512 4210244 3789116..3789955 1 NC_008258.1 Code: L; COG: COG2801; IS2 ORF2 3789955 4210244 SFV_3702 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_691032.1 3789116 D 373384 CDS YP_691033.1 110807513 4210245 complement(3790125..3791360) 1 NC_008258.1 Code: R; COG: COG0641; arylsulfatase regulator 3791360 aslB 4210245 aslB Shigella flexneri 5 str. 8401 arylsulfatase regulator YP_691033.1 3790125 R 373384 CDS YP_691034.1 110807514 4209121 complement(3792046..3793431) 1 NC_008258.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transport protein YifK 3793431 yifK 4209121 yifK Shigella flexneri 5 str. 8401 transport protein YifK YP_691034.1 3792046 R 373384 CDS YP_691035.1 110807515 4209122 complement(3793622..3794362) 1 NC_008258.1 Code: M; COG: COG1922; UDP-N-acetyl-D-mannosaminuronic acid transferase 3794362 wecG 4209122 wecG Shigella flexneri 5 str. 8401 UDP-N-acetyl-D-mannosaminuronic acid transferase YP_691035.1 3793622 R 373384 CDS YP_691036.1 110807516 4209123 complement(3794365..3795717) 1 NC_008258.1 enterobacterial common antigen polymerase; common antigen polymerase 3795717 wecF 4209123 wecF Shigella flexneri 5 str. 8401 common antigen polymerase YP_691036.1 3794365 R 373384 CDS YP_691037.1 110807517 4209124 complement(3795714..3796793) 1 NC_008258.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 3796793 yifM 4209124 yifM Shigella flexneri 5 str. 8401 4-alpha-L-fucosyltransferase YP_691037.1 3795714 R 373384 CDS YP_691038.1 110807518 4209125 complement(3796790..3798040) 1 NC_008258.1 Code: R; COG: COG2244; cytochrome 3798040 wzxE 4209125 wzxE Shigella flexneri 5 str. 8401 cytochrome YP_691038.1 3796790 R 373384 CDS YP_691039.1 110807519 4209126 complement(3798042..3799172) 1 NC_008258.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 3799172 wecE 4209126 wecE Shigella flexneri 5 str. 8401 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_691039.1 3798042 R 373384 CDS YP_691040.1 110807520 4209127 complement(3799177..3799851) 1 NC_008258.1 Code: KR; COG: COG0454; TDP-fucosamine acetyltransferase 3799851 wecD 4209127 wecD Shigella flexneri 5 str. 8401 TDP-fucosamine acetyltransferase YP_691040.1 3799177 R 373384 CDS YP_691041.1 110807521 4209128 complement(3799829..3800710) 1 NC_008258.1 Code: M; COG: COG1209; glucose-1-phosphate thymidylyltransferase 3800710 rffH 4209128 rffH Shigella flexneri 5 str. 8401 glucose-1-phosphate thymidylyltransferase YP_691041.1 3799829 R 373384 CDS YP_691042.1 110807522 4209129 complement(3800729..3801796) 1 NC_008258.1 Code: M; COG: COG1088; dTDP-glucose 4,6-dehydratase 3801796 rffG 4209129 rffG Shigella flexneri 5 str. 8401 dTDP-glucose 4,6-dehydratase YP_691042.1 3800729 R 373384 CDS YP_691043.1 110807523 4209130 complement(3801796..3803058) 1 NC_008258.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 3803058 wecC 4209130 wecC Shigella flexneri 5 str. 8401 UDP-N-acetyl-D-mannosamine dehydrogenase YP_691043.1 3801796 R 373384 CDS YP_691044.1 110807524 4209131 complement(3803055..3804185) 1 NC_008258.1 Code: M; COG: COG0381; UDP-N-acetyl glucosamine-2-epimerase 3804185 wecB 4209131 wecB Shigella flexneri 5 str. 8401 UDP-N-acetyl glucosamine-2-epimerase YP_691044.1 3803055 R 373384 CDS YP_691045.1 110807525 4209132 complement(3804241..3805287) 1 NC_008258.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 3805287 wzzE 4209132 wzzE Shigella flexneri 5 str. 8401 lipopolysaccharide biosynthesis protein WzzE YP_691045.1 3804241 R 373384 CDS YP_691046.1 110807526 4209133 complement(3805299..3806402) 1 NC_008258.1 Code: M; COG: COG0472; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 3806402 rfe 4209133 rfe Shigella flexneri 5 str. 8401 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_691046.1 3805299 R 373384 CDS YP_691047.1 110807527 4209134 complement(3806414..3806632) 1 NC_008258.1 hypothetical protein 3806632 4209134 SFV_3721 Shigella flexneri 5 str. 8401 hypothetical protein YP_691047.1 3806414 R 373384 CDS YP_691048.1 110807528 4209135 complement(3806642..3807973) 1 NC_008258.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 3807973 rho 4209135 rho Shigella flexneri 5 str. 8401 transcription termination factor Rho YP_691048.1 3806642 R 373384 CDS YP_691049.1 110807529 4211122 complement(3808228..3808662) 1 NC_008258.1 Code: OC; COG: COG0526; thioredoxin 3808662 trxA 4211122 trxA Shigella flexneri 5 str. 8401 thioredoxin YP_691049.1 3808228 R 373384 CDS YP_691050.1 110807530 4211123 3808688..3809953 1 NC_008258.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 3809953 rhlB 4211123 rhlB Shigella flexneri 5 str. 8401 ATP-dependent RNA helicase RhlB YP_691050.1 3808688 D 373384 CDS YP_691051.1 110807531 4211124 3810087..3811571 1 NC_008258.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 3811571 gppA 4211124 gppA Shigella flexneri 5 str. 8401 guanosine pentaphosphate phosphohydrolase YP_691051.1 3810087 D 373384 CDS YP_691052.1 110807532 4211125 complement(3811618..3813654) 1 NC_008258.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 3813654 rep 4211125 rep Shigella flexneri 5 str. 8401 ATP-dependent DNA helicase Rep YP_691052.1 3811618 R 373384 CDS YP_691053.1 110807533 4211126 3813726..3814007 1 NC_008258.1 Code: O; COG: COG0760; peptidyl-prolyl cis-trans isomerase C 3814007 ppiC 4211126 ppiC Shigella flexneri 5 str. 8401 peptidyl-prolyl cis-trans isomerase C YP_691053.1 3813726 D 373384 CDS YP_691054.1 110807535 4211128 complement(3814053..3815663) 1 NC_008258.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3815663 ilvC 4211128 ilvC Shigella flexneri 5 str. 8401 ketol-acid reductoisomerase YP_691054.1 3814053 R 373384 CDS YP_691055.1 110807534 4211127 3815609..3816568 1 NC_008258.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 3816568 ilvY 4211127 ilvY Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator IlvY YP_691055.1 3815609 D 373384 CDS YP_691056.1 110807536 4211129 complement(3816565..3818109) 1 NC_008258.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 3818109 ilvA 4211129 ilvA Shigella flexneri 5 str. 8401 threonine dehydratase YP_691056.1 3816565 R 373384 CDS YP_691057.1 110807537 4211130 complement(3818112..3819962) 1 NC_008258.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 3819962 ilvD 4211130 ilvD Shigella flexneri 5 str. 8401 dihydroxy-acid dehydratase YP_691057.1 3818112 R 373384 CDS YP_691058.2 229774929 4211131 complement(3820027..3820956) 1 NC_008258.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3820956 ilvE 4211131 ilvE Shigella flexneri 5 str. 8401 branched-chain amino acid aminotransferase YP_691058.2 3820027 R 373384 CDS YP_691059.1 110807539 4211132 complement(3820976..3821239) 1 NC_008258.1 Code: S; COG: COG3978; acetolactate synthase 2 regulatory subunit 3821239 ilvM 4211132 ilvM Shigella flexneri 5 str. 8401 acetolactate synthase 2 regulatory subunit YP_691059.1 3820976 R 373384 CDS YP_691060.1 110807540 4211133 complement(3821236..3822882) 1 NC_008258.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 3822882 ilvG 4211133 ilvG Shigella flexneri 5 str. 8401 acetolactate synthase 2 catalytic subunit YP_691060.1 3821236 R 373384 CDS YP_691061.1 110807541 4211134 3823471..3824991 1 NC_008258.1 among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease 3824991 yifB 4211134 yifB Shigella flexneri 5 str. 8401 ATP-dependent protease YP_691061.1 3823471 D 373384 CDS YP_691062.1 110807542 4211135 complement(3825016..3825354) 1 NC_008258.1 Code: S; COG: COG3085; hypothetical protein 3825354 yifE 4211135 yifE Shigella flexneri 5 str. 8401 hypothetical protein YP_691062.1 3825016 R 373384 CDS YP_691063.1 110807543 4211136 3825473..3826312 1 NC_008258.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 3826312 yifDA 4211136 yifDA Shigella flexneri 5 str. 8401 transcriptional regulator HdfR YP_691063.1 3825473 D 373384 CDS YP_691064.1 110807544 4206768 3832116..3832808 1 NC_008258.1 Code: K; COG: COG2186; hypothetical protein 3832808 yieP 4206768 yieP Shigella flexneri 5 str. 8401 hypothetical protein YP_691064.1 3832116 D 373384 CDS YP_691065.1 110807545 4206769 3832855..3834258 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 3834258 yieO 4206769 yieO Shigella flexneri 5 str. 8401 transport protein YP_691065.1 3832855 D 373384 CDS YP_691066.1 110807546 4206770 complement(3834224..3835207) 1 NC_008258.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 3835207 rbsR 4206770 rbsR Shigella flexneri 5 str. 8401 transcriptional repressor RbsR YP_691066.1 3834224 R 373384 CDS YP_691067.1 110807547 4206771 complement(3835220..3836164) 1 NC_008258.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 3836164 rbsK 4206771 rbsK Shigella flexneri 5 str. 8401 ribokinase YP_691067.1 3835220 R 373384 CDS YP_691068.1 110807548 4206773 complement(3837186..3838151) 1 NC_008258.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 3838151 rbsC 4206773 rbsC Shigella flexneri 5 str. 8401 ribose ABC transporter permease YP_691068.1 3837186 R 373384 CDS YP_691069.1 110807549 4206774 complement(3839333..3839836) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3839836 insB 4206774 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691069.1 3839333 R 373384 CDS YP_691070.1 110807550 4206776 complement(3840445..3840864) 1 NC_008258.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 3840864 rbsD 4206776 rbsD Shigella flexneri 5 str. 8401 D-ribose pyranase YP_691070.1 3840445 R 373384 CDS YP_691071.1 110807551 4206777 complement(3841031..3842899) 1 NC_008258.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 3842899 trkD 4206777 trkD Shigella flexneri 5 str. 8401 potassium transport protein Kup YP_691071.1 3841031 R 373384 CDS YP_691072.1 110807552 4206778 complement(3843057..3844403) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 3844403 4206778 SFV_3754 Shigella flexneri 5 str. 8401 IS4 orf YP_691072.1 3843057 R 373384 CDS YP_691073.1 110807553 4206779 complement(3844506..3846335) 1 NC_008258.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 3846335 glmS 4206779 glmS Shigella flexneri 5 str. 8401 glucosamine--fructose-6-phosphate aminotransferase YP_691073.1 3844506 R 373384 CDS YP_691074.1 110807554 4207760 complement(3846497..3847867) 1 NC_008258.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 3847867 glmU 4207760 glmU Shigella flexneri 5 str. 8401 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_691074.1 3846497 R 373384 CDS YP_691075.1 110807555 4207761 complement(3848219..3848638) 1 NC_008258.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 3848638 atpC 4207761 atpC Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit epsilon YP_691075.1 3848219 R 373384 CDS YP_691076.1 110807556 4207762 complement(3848659..3850041) 1 NC_008258.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 3850041 atpD 4207762 atpD Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit beta YP_691076.1 3848659 R 373384 CDS YP_691077.1 110807557 4207763 complement(3850068..3850931) 1 NC_008258.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 3850931 atpG 4207763 atpG Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit gamma YP_691077.1 3850068 R 373384 CDS YP_691078.1 110807558 4207764 complement(3850982..3852523) 1 NC_008258.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 3852523 atpA 4207764 atpA Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit alpha YP_691078.1 3850982 R 373384 CDS YP_691079.1 110807559 4207765 complement(3852536..3853069) 1 NC_008258.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 3853069 atpH 4207765 atpH Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit delta YP_691079.1 3852536 R 373384 CDS YP_691080.1 110807560 4207766 complement(3853084..3853554) 1 NC_008258.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 3853554 atpF 4207766 atpF Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit B YP_691080.1 3853084 R 373384 CDS YP_691081.1 110807561 4207767 complement(3853616..3853855) 1 NC_008258.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 3853855 atpE 4207767 atpE Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit C YP_691081.1 3853616 R 373384 CDS YP_691082.1 110807562 4207768 complement(3853902..3854717) 1 NC_008258.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 3854717 atpB 4207768 atpB Shigella flexneri 5 str. 8401 ATP synthase F0F1 subunit A YP_691082.1 3853902 R 373384 CDS YP_691083.1 110807563 4207769 complement(3854726..3855106) 1 NC_008258.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 3855106 atpI 4207769 atpI Shigella flexneri 5 str. 8401 F0F1 ATP synthase subunit I YP_691083.1 3854726 R 373384 CDS YP_691084.1 110807564 4207770 complement(3855723..3856346) 1 NC_008258.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 3856346 gidB 4207770 gidB Shigella flexneri 5 str. 8401 16S rRNA methyltransferase GidB YP_691084.1 3855723 R 373384 CDS YP_691085.1 110807565 4207771 complement(3856410..3858218) 1 NC_008258.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 3858218 gidA 4207771 gidA Shigella flexneri 5 str. 8401 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_691085.1 3856410 R 373384 CDS YP_691086.1 110807566 4207772 complement(3858678..3859121) 1 NC_008258.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3859121 mioC 4207772 mioC Shigella flexneri 5 str. 8401 flavodoxin YP_691086.1 3858678 R 373384 CDS YP_691087.1 110807567 4207773 complement(3859211..3859669) 1 NC_008258.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 3859669 asnC 4207773 asnC Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator AsnC YP_691087.1 3859211 R 373384 CDS YP_691088.1 110807568 4207774 3859821..3860813 1 NC_008258.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 3860813 asnA 4207774 asnA Shigella flexneri 5 str. 8401 asparagine synthetase AsnA YP_691088.1 3859821 D 373384 CDS YP_691089.1 110807569 4207775 complement(3860818..3862269) 1 NC_008258.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 3862269 yieM 4207775 yieM Shigella flexneri 5 str. 8401 hypothetical protein YP_691089.1 3860818 R 373384 CDS YP_691090.2 229774928 4207776 complement(3862263..3863759) 1 NC_008258.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 3863759 yieN 4207776 yieN Shigella flexneri 5 str. 8401 regulatory ATPase RavA YP_691090.2 3862263 R 373384 CDS YP_691091.1 110807571 4207777 3863914..3865260 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 3865260 4207777 SFV_3773 Shigella flexneri 5 str. 8401 IS4 orf YP_691091.1 3863914 D 373384 CDS YP_691092.1 110807572 4207778 3865552..3866124 1 NC_008258.1 Code: NU; COG: COG3539; major fimbrial subunit 3866124 lpfA 4207778 lpfA Shigella flexneri 5 str. 8401 major fimbrial subunit YP_691092.1 3865552 D 373384 CDS YP_691093.2 162139322 4207779 complement(3866890..3867795) 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3867795 4207779 SFV_3775 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_691093.2 3866890 R 373384 CDS YP_691094.1 110807574 4210463 complement(3867753..3868118) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3868118 4210463 SFV_3776 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_691094.1 3867753 R 373384 CDS YP_691095.1 110807575 4210464 3868267..3870786 1 NC_008258.1 Code: NU; COG: COG3188; long polar fimbriae 3870786 lpfC 4210464 lpfC Shigella flexneri 5 str. 8401 long polar fimbriae YP_691095.1 3868267 D 373384 CDS YP_691096.1 110807576 4210465 3870797..3871870 1 NC_008258.1 Code: NU; COG: COG3539; fimbrial protein 3871870 4210465 SFV_3778 Shigella flexneri 5 str. 8401 fimbrial protein YP_691096.1 3870797 D 373384 CDS YP_691097.1 110807577 4210466 3872118..3873158 1 NC_008258.1 Code: P; COG: COG0226; phosphate ABC transporter periplasmic substrate-binding protein PstS 3873158 pstS 4210466 pstS Shigella flexneri 5 str. 8401 phosphate ABC transporter periplasmic substrate-binding protein PstS YP_691097.1 3872118 D 373384 CDS YP_691098.1 110807578 4210467 3873245..3874204 1 NC_008258.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 3874204 pstC 4210467 pstC Shigella flexneri 5 str. 8401 phosphate transporter permease subunit PstC YP_691098.1 3873245 D 373384 CDS YP_691099.1 110807579 4210468 3874204..3875094 1 NC_008258.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 3875094 pstA 4210468 pstA Shigella flexneri 5 str. 8401 phosphate transporter permease subunit PtsA YP_691099.1 3874204 D 373384 CDS YP_691100.1 110807580 4210469 3875186..3875959 1 NC_008258.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 3875959 pstB 4210469 pstB Shigella flexneri 5 str. 8401 phosphate transporter ATP-binding protein YP_691100.1 3875186 D 373384 CDS YP_691101.1 110807581 4210470 3875974..3876699 1 NC_008258.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 3876699 phoU 4210470 phoU Shigella flexneri 5 str. 8401 transcriptional regulator PhoU YP_691101.1 3875974 D 373384 CDS YP_691102.1 110807582 4210471 3876986..3877822 1 NC_008258.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator; transcriptional antiterminator BglG 3877822 bglG 4210471 bglG Shigella flexneri 5 str. 8401 transcriptional antiterminator BglG YP_691102.1 3876986 D 373384 CDS YP_691103.1 110807583 4210472 3878019..3879833 1 NC_008258.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunits IIABC 3879833 bglF 4210472 bglF Shigella flexneri 5 str. 8401 PTS system beta-glucoside-specific transporter subunits IIABC YP_691103.1 3878019 D 373384 CDS YP_691104.1 110807584 4210473 3879852..3881246 1 NC_008258.1 Code: G; COG: COG2723; phospho-beta-glucosidase B; cryptic 3881246 bglB 4210473 bglB Shigella flexneri 5 str. 8401 phospho-beta-glucosidase B; cryptic YP_691104.1 3879852 D 373384 CDS YP_691105.1 110807585 4210474 3881332..3882948 1 NC_008258.1 Code: G; COG: COG4580; receptor protein 3882948 yieC 4210474 yieC Shigella flexneri 5 str. 8401 receptor protein YP_691105.1 3881332 D 373384 CDS YP_691106.1 110807586 4210475 3883050..3884150 1 NC_008258.1 Code: P; COG: COG2382; xylanase 3884150 yieL 4210475 yieL Shigella flexneri 5 str. 8401 xylanase YP_691106.1 3883050 D 373384 CDS YP_691107.1 110807587 4210476 3884152..3884874 1 NC_008258.1 Code: G; COG: COG0363; 6-phosphogluconolactonase 3884874 yieK 4210476 yieK Shigella flexneri 5 str. 8401 6-phosphogluconolactonase YP_691107.1 3884152 D 373384 CDS YP_691108.1 110807588 4210477 complement(3884936..3885352) 1 NC_008258.1 Code: S; COG: COG3196; hypothetical protein 3885352 yieJ 4210477 yieJ Shigella flexneri 5 str. 8401 hypothetical protein YP_691108.1 3884936 R 373384 CDS YP_691109.1 110807589 4210478 complement(3885527..3886333) 1 NC_008258.1 ISSfl4 ORF3 3886333 4210478 SFV_3791 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_691109.1 3885527 R 373384 CDS YP_691110.1 110807590 4210479 complement(3886309..3886443) 1 NC_008258.1 ISSfl4 ORF3 3886443 4210479 SFV_3792 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_691110.1 3886309 R 373384 CDS YP_691111.1 110807591 4210480 complement(3886463..3886810) 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 3886810 4210480 SFV_3793 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_691111.1 3886463 R 373384 CDS YP_691112.1 110807592 4210481 complement(3886807..3887481) 1 NC_008258.1 ISSfl4 ORF1 3887481 4210481 SFV_3794 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_691112.1 3886807 R 373384 CDS YP_691113.1 110807593 4209692 complement(3887649..3888122) 1 NC_008258.1 might be involved in hypersensitivity to nitrofurzone; inner membrane protein 3888122 yieI 4209692 yieI Shigella flexneri 5 str. 8401 inner membrane protein YP_691113.1 3887649 R 373384 CDS YP_691114.1 110807594 4209693 complement(3888189..3888845) 1 NC_008258.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 3888845 yieH 4209693 yieH Shigella flexneri 5 str. 8401 6-phosphogluconate phosphatase YP_691114.1 3888189 R 373384 CDS YP_691115.1 110807595 4209694 3889010..3890347 1 NC_008258.1 Code: R; COG: COG2252; membrane / transport protein 3890347 yieG 4209694 yieG Shigella flexneri 5 str. 8401 membrane / transport protein YP_691115.1 3889010 D 373384 CDS YP_691116.1 110807596 4209695 complement(3890401..3890967) 1 NC_008258.1 Code: R; COG: COG0431; hypothetical protein 3890967 yieF 4209695 yieF Shigella flexneri 5 str. 8401 hypothetical protein YP_691116.1 3890401 R 373384 CDS YP_691117.1 110807597 4209696 complement(3890989..3891738) 1 NC_008258.1 Code: H; COG: COG2091; hypothetical protein 3891738 yieE 4209696 yieE Shigella flexneri 5 str. 8401 hypothetical protein YP_691117.1 3890989 R 373384 CDS YP_691118.1 110807598 4209697 3892273..3892575 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 3892575 4209697 SFV_3800 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_691118.1 3892273 D 373384 CDS YP_691119.1 110807599 4209698 3892716..3893429 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 3893429 4209698 SFV_3801 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_691119.1 3892716 D 373384 CDS YP_691120.1 110807600 4209699 complement(3893426..3894028) 1 NC_008258.1 LysR family transcriptional regulator 3894028 4209699 SFV_3802 Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_691120.1 3893426 R 373384 CDS YP_691121.1 110807601 4209700 complement(3894096..3895271) 1 NC_008258.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 3895271 yidY 4209700 yidY Shigella flexneri 5 str. 8401 multidrug efflux system protein MdtL YP_691121.1 3894096 R 373384 CDS YP_691122.1 110807602 4209701 complement(3895403..3896650) 1 NC_008258.1 tryptophan transporter of low affinity; tryptophan permease 3896650 tnaB 4209701 tnaB Shigella flexneri 5 str. 8401 tryptophan permease YP_691122.1 3895403 R 373384 CDS YP_691123.1 110807603 4209702 complement(3896741..3898156) 1 NC_008258.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 3898156 tnaA 4209702 tnaA Shigella flexneri 5 str. 8401 tryptophanase YP_691123.1 3896741 R 373384 CDS YP_691124.1 110807604 4209703 complement(3898693..3900057) 1 NC_008258.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 3900057 trmE 4209703 trmE Shigella flexneri 5 str. 8401 tRNA modification GTPase TrmE YP_691124.1 3898693 R 373384 CDS YP_691125.1 110807605 4209704 complement(3900163..3901758) 1 NC_008258.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 3901758 yidC 4209704 yidC Shigella flexneri 5 str. 8401 inner membrane protein translocase component YidC YP_691125.1 3900163 R 373384 CDS YP_691126.1 110807606 4209705 complement(3902033..3902359) 1 NC_008258.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 3902359 rnpA 4209705 rnpA Shigella flexneri 5 str. 8401 ribonuclease P YP_691126.1 3902033 R 373384 CDS YP_691127.1 110807607 4209706 complement(3902409..3902549) 1 NC_008258.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 3902549 rpmH 4209706 rpmH Shigella flexneri 5 str. 8401 50S ribosomal protein L34 YP_691127.1 3902409 R 373384 CDS YP_691128.1 110807608 4209707 3903225..3904556 1 NC_008258.1 Code: L; COG: COG0593; chromosome replication initiator DnaA 3904556 dnaA 4209707 dnaA Shigella flexneri 5 str. 8401 chromosome replication initiator DnaA YP_691128.1 3903225 D 373384 CDS YP_691129.1 110807609 4209708 3904561..3905661 1 NC_008258.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3905661 dnaN 4209708 dnaN Shigella flexneri 5 str. 8401 DNA polymerase III subunit beta YP_691129.1 3904561 D 373384 CDS YP_691130.1 110807610 4209709 3905661..3906734 1 NC_008258.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3906734 recF 4209709 recF Shigella flexneri 5 str. 8401 recombination protein F YP_691130.1 3905661 D 373384 CDS YP_691131.1 110807611 4209710 3906763..3909177 1 NC_008258.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 3909177 gyrB 4209710 gyrB Shigella flexneri 5 str. 8401 DNA gyrase subunit B YP_691131.1 3906763 D 373384 CDS YP_691132.1 110807612 4209711 3909417..3909815 1 NC_008258.1 Code: S; COG: COG3753; hypothetical protein 3909815 yidB 4209711 yidB Shigella flexneri 5 str. 8401 hypothetical protein YP_691132.1 3909417 D 373384 CDS YP_691133.1 110807613 4210327 3909929..3910741 1 NC_008258.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 3910741 yidA 4210327 yidA Shigella flexneri 5 str. 8401 sugar phosphatase YP_691133.1 3909929 D 373384 CDS YP_691134.2 229774927 4210328 complement(3910787..3911443) 1 NC_008258.1 hypothetical protein 3911443 4210328 SFV_3816 Shigella flexneri 5 str. 8401 hypothetical protein YP_691134.2 3910787 R 373384 CDS YP_691135.1 110807615 4210330 3912407..3913285 1 NC_008258.1 Code: G; COG: COG3734; 2-oxo-3-deoxygalactonate kinase 3913285 dgoK 4210330 dgoK Shigella flexneri 5 str. 8401 2-oxo-3-deoxygalactonate kinase YP_691135.1 3912407 D 373384 CDS YP_691136.1 110807616 4210332 3915124..3916443 1 NC_008258.1 Code: GEPR; COG: COG0477; D-galactonate transport protein 3916443 dgoT 4210332 dgoT Shigella flexneri 5 str. 8401 D-galactonate transport protein YP_691136.1 3915124 D 373384 CDS YP_691137.1 110807617 4210333 complement(3916404..3917504) 1 NC_008258.1 FAD/NAD(P)-binding domain; oxidoreductase 3917504 yidS 4210333 yidS Shigella flexneri 5 str. 8401 oxidoreductase YP_691137.1 3916404 R 373384 CDS YP_691138.1 110807618 4210334 3917605..3918825 1 NC_008258.1 hypothetical protein 3918825 yidR 4210334 yidR Shigella flexneri 5 str. 8401 hypothetical protein YP_691138.1 3917605 D 373384 CDS YP_691139.1 110807619 4210335 complement(3918827..3919234) 1 NC_008258.1 Code: R; COG: COG5645; hypothetical protein 3919234 yidQ 4210335 yidQ Shigella flexneri 5 str. 8401 hypothetical protein YP_691139.1 3918827 R 373384 CDS YP_691140.1 110807620 4210336 3919464..3919877 1 NC_008258.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 3919877 ibpA 4210336 ibpA Shigella flexneri 5 str. 8401 heat shock protein IbpA YP_691140.1 3919464 D 373384 CDS YP_691141.1 110807621 4210337 3919989..3920417 1 NC_008258.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 3920417 ibpB 4210337 ibpB Shigella flexneri 5 str. 8401 heat shock chaperone IbpB YP_691141.1 3919989 D 373384 CDS YP_691142.1 110807622 4210338 3920613..3922274 1 NC_008258.1 Code: R; COG: COG2985; hypothetical protein 3922274 yidE 4210338 yidE Shigella flexneri 5 str. 8401 hypothetical protein YP_691142.1 3920613 D 373384 CDS YP_691143.1 110807623 4210339 complement(3922313..3922987) 1 NC_008258.1 Code: K; COG: COG2188; transcriptional regulator 3922987 yidP 4210339 yidP Shigella flexneri 5 str. 8401 transcriptional regulator YP_691143.1 3922313 R 373384 CDS YP_691144.1 110807624 4210340 3923075..3924895 1 NC_008258.1 Code: G; COG: COG1263; phosphotransferase system IIBC component 3924895 glvC 4210340 glvC Shigella flexneri 5 str. 8401 phosphotransferase system IIBC component YP_691144.1 3923075 D 373384 CDS YP_691145.1 110807625 4210342 complement(3925706..3926599) 1 NC_008258.1 Code: K; COG: COG2207; AraC family transcriptional regulator 3926599 yidL 4210342 yidL Shigella flexneri 5 str. 8401 AraC family transcriptional regulator YP_691145.1 3925706 R 373384 CDS YP_691146.1 110807626 4210343 3926766..3928481 1 NC_008258.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK 3928481 yidK 4210343 yidK Shigella flexneri 5 str. 8401 symporter YidK YP_691146.1 3926766 D 373384 CDS YP_691147.1 110807627 4210344 3928516..3929958 1 NC_008258.1 Code: P; COG: COG3119; sulfatase 3929958 yidJ 4210344 yidJ Shigella flexneri 5 str. 8401 sulfatase YP_691147.1 3928516 D 373384 CDS YP_691148.1 110807628 4210345 complement(3930005..3930418) 1 NC_008258.1 hypothetical protein 3930418 yidI 4210345 yidI Shigella flexneri 5 str. 8401 hypothetical protein YP_691148.1 3930005 R 373384 CDS YP_691149.1 110807629 4210307 3930527..3930874 1 NC_008258.1 Code: S; COG: COG2149; hypothetical protein 3930874 yidH 4210307 yidH Shigella flexneri 5 str. 8401 hypothetical protein YP_691149.1 3930527 D 373384 CDS YP_691150.1 110807630 4210308 3930864..3931226 1 NC_008258.1 hypothetical protein 3931226 yidG 4210308 yidG Shigella flexneri 5 str. 8401 hypothetical protein YP_691150.1 3930864 D 373384 CDS YP_691151.1 110807631 4210309 3931223..3931720 1 NC_008258.1 Code: R; COG: COG0641; transcriptional regulator 3931720 yidF 4210309 yidF Shigella flexneri 5 str. 8401 transcriptional regulator YP_691151.1 3931223 D 373384 CDS YP_691152.1 110807632 4210310 complement(3931728..3932918) 1 NC_008258.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 3932918 emrD 4210310 emrD Shigella flexneri 5 str. 8401 multidrug resistance protein D YP_691152.1 3931728 R 373384 CDS YP_691153.1 110807633 4210311 3934050..3935738 1 NC_008258.1 Code: EH; COG: COG0028; acetolactate synthase catalytic subunit 3935738 ilvB 4210311 ilvB Shigella flexneri 5 str. 8401 acetolactate synthase catalytic subunit YP_691153.1 3934050 D 373384 CDS YP_691154.1 110807634 4210312 3935742..3936032 1 NC_008258.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 3936032 ilvN 4210312 ilvN Shigella flexneri 5 str. 8401 acetolactate synthase 1 regulatory subunit YP_691154.1 3935742 D 373384 CDS YP_691155.1 110807635 4210313 3936107..3936697 1 NC_008258.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 3936697 uhpA 4210313 uhpA Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator UhpA YP_691155.1 3936107 D 373384 CDS YP_691156.1 110807636 4210314 3936694..3938199 1 NC_008258.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 3938199 uhpB 4210314 uhpB Shigella flexneri 5 str. 8401 sensory histidine kinase UhpB YP_691156.1 3936694 D 373384 CDS YP_691157.1 110807637 4210315 3938206..3939528 1 NC_008258.1 membrane protein regulates uhpT expression; regulatory protein UhpC 3939528 uhpC 4210315 uhpC Shigella flexneri 5 str. 8401 regulatory protein UhpC YP_691157.1 3938206 D 373384 CDS YP_691158.1 110807638 4210316 3939666..3941057 1 NC_008258.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 3941057 uhpT 4210316 uhpT Shigella flexneri 5 str. 8401 sugar phosphate antiporter YP_691158.1 3939666 D 373384 CDS YP_691159.1 110807639 4210317 complement(3941103..3942869) 1 NC_008258.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 3942869 yicP 4210317 yicP Shigella flexneri 5 str. 8401 cryptic adenine deaminase YP_691159.1 3941103 R 373384 CDS YP_691160.1 110807640 4210318 3942966..3944378 1 NC_008258.1 Code: R; COG: COG2252; hypothetical protein 3944378 yicO 4210318 yicO Shigella flexneri 5 str. 8401 hypothetical protein YP_691160.1 3942966 D 373384 CDS YP_691161.1 110807641 4210319 3944431..3944883 1 NC_008258.1 hypothetical protein 3944883 yicN 4210319 yicN Shigella flexneri 5 str. 8401 hypothetical protein YP_691161.1 3944431 D 373384 CDS YP_691162.2 162139321 4210320 3945094..3946284 1 NC_008258.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 3946284 nepI 4210320 nepI Shigella flexneri 5 str. 8401 ribonucleoside transporter YP_691162.2 3945094 D 373384 CDS YP_691163.1 110807643 4210321 3946873..3947175 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 3947175 4210321 SFV_3848 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_691163.1 3946873 D 373384 CDS YP_691164.1 110807644 4210322 3947316..3948029 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 3948029 4210322 SFV_3849 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_691164.1 3947316 D 373384 CDS YP_691165.1 110807645 4210323 complement(3948286..3950484) 1 NC_008258.1 Code: P; COG: COG1629; ferric siderophore receptor 3950484 iutA 4210323 iutA Shigella flexneri 5 str. 8401 ferric siderophore receptor YP_691165.1 3948286 R 373384 CDS YP_691166.1 110807646 4210324 complement(3950487..3951824) 1 NC_008258.1 Code: Q; COG: COG3486; lysine:N6-hydroxylase 3951824 iucD 4210324 iucD Shigella flexneri 5 str. 8401 lysine:N6-hydroxylase YP_691166.1 3950487 R 373384 CDS YP_691167.1 110807647 4210325 complement(3951821..3953563) 1 NC_008258.1 Code: Q; COG: COG4264; siderophore biosynthesis protein 3953563 iucC 4210325 iucC Shigella flexneri 5 str. 8401 siderophore biosynthesis protein YP_691167.1 3951821 R 373384 CDS YP_691168.1 110807648 4210326 complement(3953563..3954510) 1 NC_008258.1 Code: J; COG: COG1670; siderophore biosynthesis protein 3954510 iucB 4210326 iucB Shigella flexneri 5 str. 8401 siderophore biosynthesis protein YP_691168.1 3953563 R 373384 CDS YP_691169.1 110807649 4207099 complement(3954511..3956235) 1 NC_008258.1 siderophore biosynthesis protein 3956235 iucA 4207099 iucA Shigella flexneri 5 str. 8401 siderophore biosynthesis protein YP_691169.1 3954511 R 373384 CDS YP_691170.1 110807650 4207100 3956371..3957564 1 NC_008258.1 Code: GEPR; COG: COG0477; membrane transport protein 3957564 imm 4207100 imm Shigella flexneri 5 str. 8401 membrane transport protein YP_691170.1 3956371 D 373384 CDS YP_691171.1 110807651 4207101 complement(3957937..3958446) 1 NC_008258.1 hypothetical protein 3958446 shiE 4207101 shiE Shigella flexneri 5 str. 8401 hypothetical protein YP_691171.1 3957937 R 373384 CDS YP_691172.1 110807652 4207102 3958560..3959063 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 3959063 insB 4207102 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691172.1 3958560 D 373384 CDS YP_691173.1 110807653 4207103 3961535..3961900 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3961900 4207103 SFV_3858 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_691173.1 3961535 D 373384 CDS YP_691174.2 162139320 4207104 3961858..3962763 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3962763 4207104 SFV_3859 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_691174.2 3961858 D 373384 CDS YP_691175.1 110807655 4207105 3962738..3963193 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 3963193 4207105 SFV_3860 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_691175.1 3962738 D 373384 CDS YP_691176.2 162139319 4207106 3963151..3964056 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 3964056 4207106 SFV_3861 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_691176.2 3963151 D 373384 CDS YP_691177.1 110807657 4207107 3964826..3965152 1 NC_008258.1 Code: L; COG: COG2963; IS629 ORF1 3965152 4207107 SFV_3862 Shigella flexneri 5 str. 8401 IS629 ORF1 YP_691177.1 3964826 D 373384 CDS YP_691178.1 110807658 4207108 3965388..3966035 1 NC_008258.1 Code: L; COG: COG2801; IS629 ORF2 3966035 4207108 SFV_3863 Shigella flexneri 5 str. 8401 IS629 ORF2 YP_691178.1 3965388 D 373384 CDS YP_691179.1 110807659 4207109 complement(3966106..3966363) 1 NC_008258.1 hypothetical protein 3966363 4207109 SFV_3864 Shigella flexneri 5 str. 8401 hypothetical protein YP_691179.1 3966106 R 373384 CDS YP_691180.1 110807660 4207110 3966825..3967124 1 NC_008258.1 Code: L; COG: COG2963; IS3 ORF1 3967124 4207110 SFV_3865 Shigella flexneri 5 str. 8401 IS3 ORF1 YP_691180.1 3966825 D 373384 CDS YP_691181.1 110807661 4207111 3967121..3967513 1 NC_008258.1 IS3 ORF2 3967513 4207111 SFV_3866 Shigella flexneri 5 str. 8401 IS3 ORF2 YP_691181.1 3967121 D 373384 CDS YP_691182.1 110807662 4207112 3967485..3967976 1 NC_008258.1 IS3 ORF2 3967976 4207112 SFV_3867 Shigella flexneri 5 str. 8401 IS3 ORF2 YP_691182.1 3967485 D 373384 CDS YP_691183.1 110807663 4207113 complement(3967973..3968434) 1 NC_008258.1 hypothetical protein 3968434 shiB 4207113 shiB Shigella flexneri 5 str. 8401 hypothetical protein YP_691183.1 3967973 R 373384 CDS YP_691184.1 110807664 4207114 complement(3968949..3969992) 1 NC_008258.1 hypothetical protein 3969992 shiA 4207114 shiA Shigella flexneri 5 str. 8401 hypothetical protein YP_691184.1 3968949 R 373384 CDS YP_691185.1 110807665 4207115 complement(3970404..3971588) 1 NC_008258.1 Code: L; COG: COG0582; integrase 3971588 intC 4207115 intC Shigella flexneri 5 str. 8401 integrase YP_691185.1 3970404 R 373384 CDS YP_691186.1 110807666 4210249 3973761..3975986 1 NC_008258.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase YicI 3975986 yicI 4210249 yicI Shigella flexneri 5 str. 8401 alpha-xylosidase YicI YP_691186.1 3973761 D 373384 CDS YP_691187.1 110807667 4210250 complement(3976039..3977748) 1 NC_008258.1 hypothetical protein 3977748 yicH 4210250 yicH Shigella flexneri 5 str. 8401 hypothetical protein YP_691187.1 3976039 R 373384 CDS YP_691188.1 110807668 4210251 complement(3977869..3979260) 1 NC_008258.1 Code: F; COG: COG2233; transport protein 3979260 yicE 4210251 yicE Shigella flexneri 5 str. 8401 transport protein YP_691188.1 3977869 R 373384 CDS YP_691189.1 110807669 4210252 3979540..3980745 1 NC_008258.1 Code: E; COG: COG0786; glutamate transport protein 3980745 gltS 4210252 gltS Shigella flexneri 5 str. 8401 glutamate transport protein YP_691189.1 3979540 D 373384 CDS YP_691190.1 110807670 4210253 complement(3980779..3982860) 1 NC_008258.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3982860 recG 4210253 recG Shigella flexneri 5 str. 8401 ATP-dependent DNA helicase RecG YP_691190.1 3980779 R 373384 CDS YP_691191.1 110807671 4210254 complement(3982866..3983555) 1 NC_008258.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 3983555 spoU 4210254 spoU Shigella flexneri 5 str. 8401 tRNA guanosine-2'-O-methyltransferase YP_691191.1 3982866 R 373384 CDS YP_691192.1 110807672 4210255 complement(3983562..3985670) 1 NC_008258.1 Code: TK; COG: COG0317; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 3985670 spoT 4210255 spoT Shigella flexneri 5 str. 8401 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_691192.1 3983562 R 373384 CDS YP_691193.1 110807673 4210256 complement(3985689..3985964) 1 NC_008258.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 3985964 rpoZ 4210256 rpoZ Shigella flexneri 5 str. 8401 DNA-directed RNA polymerase subunit omega YP_691193.1 3985689 R 373384 CDS YP_691194.1 110807674 4210257 complement(3986019..3986699) 1 NC_008258.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 3986699 gmk 4210257 gmk Shigella flexneri 5 str. 8401 guanylate kinase YP_691194.1 3986019 R 373384 CDS YP_691195.1 110807675 4210258 3986776..3987039 1 NC_008258.1 hypothetical protein 3987039 4210258 SFV_3882 Shigella flexneri 5 str. 8401 hypothetical protein YP_691195.1 3986776 D 373384 CDS YP_691196.1 110807676 4210259 3986894..3988582 1 NC_008258.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 3988582 ligB 4210259 ligB Shigella flexneri 5 str. 8401 NAD-dependent DNA ligase LigB YP_691196.1 3986894 D 373384 CDS YP_691197.1 110807677 4210260 complement(3988579..3989196) 1 NC_008258.1 Code: S; COG: COG2860; hypothetical protein 3989196 yicG 4210260 yicG Shigella flexneri 5 str. 8401 hypothetical protein YP_691197.1 3988579 R 373384 CDS YP_691198.1 110807678 4210261 complement(3989487..3990323) 1 NC_008258.1 DNA-damage-inducible protein D 3990323 dinD 4210261 dinD Shigella flexneri 5 str. 8401 DNA-damage-inducible protein D YP_691198.1 3989487 R 373384 CDS YP_691199.1 110807679 4210262 complement(3990533..3991396) 1 NC_008258.1 Code: S; COG: COG1561; hypothetical protein 3991396 yicC 4210262 yicC Shigella flexneri 5 str. 8401 hypothetical protein YP_691199.1 3990533 R 373384 CDS YP_691200.1 110807680 4210263 3991523..3992239 1 NC_008258.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 3992239 rph 4210263 rph Shigella flexneri 5 str. 8401 ribonuclease PH YP_691200.1 3991523 D 373384 CDS YP_691201.1 110807681 4210264 3992305..3992946 1 NC_008258.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 3992946 pyrE 4210264 pyrE Shigella flexneri 5 str. 8401 orotate phosphoribosyltransferase YP_691201.1 3992305 D 373384 CDS YP_691202.1 110807682 4210265 complement(3992983..3993579) 1 NC_008258.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 3993579 slmA 4210265 slmA Shigella flexneri 5 str. 8401 nucleoid occlusion protein YP_691202.1 3992983 R 373384 CDS YP_691203.1 110807683 4210266 complement(3993686..3994141) 1 NC_008258.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 3994141 dut 4210266 dut Shigella flexneri 5 str. 8401 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_691203.1 3993686 R 373384 CDS YP_691204.1 110807684 4210267 complement(3994122..3995342) 1 NC_008258.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 3995342 dfp 4210267 dfp Shigella flexneri 5 str. 8401 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_691204.1 3994122 R 373384 CDS YP_691205.1 110807685 4210597 3995553..3996182 1 NC_008258.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 3996182 radC 4210597 radC Shigella flexneri 5 str. 8401 DNA repair protein RadC YP_691205.1 3995553 D 373384 CDS YP_691206.1 110807686 4210598 3996656..3996823 1 NC_008258.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 3996823 rpmG 4210598 rpmG Shigella flexneri 5 str. 8401 50S ribosomal protein L33 YP_691206.1 3996656 D 373384 CDS YP_691207.1 110807687 4210599 3996921..3997730 1 NC_008258.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3997730 mutM 4210599 mutM Shigella flexneri 5 str. 8401 formamidopyrimidine-DNA glycosylase YP_691207.1 3996921 D 373384 CDS YP_691208.1 110807688 4210600 complement(3997769..3998248) 1 NC_008258.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3998248 coaD 4210600 coaD Shigella flexneri 5 str. 8401 phosphopantetheine adenylyltransferase YP_691208.1 3997769 R 373384 CDS YP_691209.1 110807689 4210601 complement(3998256..3999533) 1 NC_008258.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 3999533 kdtA 4210601 kdtA Shigella flexneri 5 str. 8401 3-deoxy-D-manno-octulosonic-acid transferase YP_691209.1 3998256 R 373384 CDS YP_691210.1 110807690 4210602 complement(3999568..3999786) 1 NC_008258.1 IS1 encoded protein 3999786 4210602 SFV_3897 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691210.1 3999568 R 373384 CDS YP_691211.1 110807691 4210603 3999861..4000364 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4000364 insB 4210603 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691211.1 3999861 D 373384 CDS YP_691212.1 110807692 4210604 4000758..4001780 1 NC_008258.1 Code: M; COG: COG0859; lipopolysaccharide core biosynthesis protein 4001780 waaQ 4210604 waaQ Shigella flexneri 5 str. 8401 lipopolysaccharide core biosynthesis protein YP_691212.1 4000758 D 373384 CDS YP_691213.1 110807693 4210605 4001777..4002901 1 NC_008258.1 Code: M; COG: COG0438; LPS alpha1,3-glucosyltransferase 4002901 waaG 4210605 waaG Shigella flexneri 5 str. 8401 LPS alpha1,3-glucosyltransferase YP_691213.1 4001777 D 373384 CDS YP_691214.1 110807694 4210606 4002894..4003691 1 NC_008258.1 lipopolysaccharide core biosynthesis protein 4003691 waaP 4210606 waaP Shigella flexneri 5 str. 8401 lipopolysaccharide core biosynthesis protein YP_691214.1 4002894 D 373384 CDS YP_691215.1 110807695 4210607 4003734..4004741 1 NC_008258.1 Code: M; COG: COG1442; Lipid A-core, surface polymer ligase 4004741 waaL 4210607 waaL Shigella flexneri 5 str. 8401 Lipid A-core, surface polymer ligase YP_691215.1 4003734 D 373384 CDS YP_691216.1 110807696 4210608 4004767..4005474 1 NC_008258.1 lipopolysaccharide core biosynthesis protein 4005474 waaY 4210608 waaY Shigella flexneri 5 str. 8401 lipopolysaccharide core biosynthesis protein YP_691216.1 4004767 D 373384 CDS YP_691217.1 110807697 4210609 4005499..4006512 1 NC_008258.1 Code: M; COG: COG1442; lipopolysaccharide 1,2-glucosyltransferase 4006512 waaJ 4210609 waaJ Shigella flexneri 5 str. 8401 lipopolysaccharide 1,2-glucosyltransferase YP_691217.1 4005499 D 373384 CDS YP_691218.1 110807698 4210610 4006521..4007663 1 NC_008258.1 Code: M; COG: COG0438; lipopolysaccharide 1,2-N- acetylglucosaminetransferase 4007663 waaD 4210610 waaD Shigella flexneri 5 str. 8401 lipopolysaccharide 1,2-N- acetylglucosaminetransferase YP_691218.1 4006521 D 373384 CDS YP_691219.1 110807699 4210611 complement(4007699..4008907) 1 NC_008258.1 Code: M; COG: COG3307; lipid A-core, surface polymer ligase 4008907 waaI 4210611 waaI Shigella flexneri 5 str. 8401 lipid A-core, surface polymer ligase YP_691219.1 4007699 R 373384 CDS YP_691220.1 110807700 4210612 complement(4008904..4009896) 1 NC_008258.1 Code: M; COG: COG0859; ADP-heptose:LPS heptosyl transferase I 4009896 waaC 4210612 waaC Shigella flexneri 5 str. 8401 ADP-heptose:LPS heptosyl transferase I YP_691220.1 4008904 R 373384 CDS YP_691221.1 110807701 4210613 complement(4009900..4010946) 1 NC_008258.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose:LPS heptosyltransferase II 4010946 waaF 4210613 waaF Shigella flexneri 5 str. 8401 ADP-heptose:LPS heptosyltransferase II YP_691221.1 4009900 R 373384 CDS YP_691222.1 110807702 4210614 complement(4010956..4011888) 1 NC_008258.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4011888 rfaD 4210614 rfaD Shigella flexneri 5 str. 8401 ADP-L-glycero-D-manno-heptose-6-epimerase YP_691222.1 4010956 R 373384 CDS YP_691223.1 110807703 4210615 4012177..4013049 1 NC_008258.1 involved in lipopolysaccharide biosynthesis; hypothetical protein 4013049 htrL 4210615 htrL Shigella flexneri 5 str. 8401 hypothetical protein YP_691223.1 4012177 D 373384 CDS YP_691224.1 110807704 4210577 4013324..4014520 1 NC_008258.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 4014520 kbl 4210577 kbl Shigella flexneri 5 str. 8401 2-amino-3-ketobutyrate CoA ligase YP_691224.1 4013324 D 373384 CDS YP_691225.1 110807705 4210578 4014530..4015555 1 NC_008258.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4015555 tdh 4210578 tdh Shigella flexneri 5 str. 8401 L-threonine 3-dehydrogenase YP_691225.1 4014530 D 373384 CDS YP_691226.1 110807706 4210579 4015797..4016636 1 NC_008258.1 Code: M; COG: COG0463; regulator 4016636 yibD 4210579 yibD Shigella flexneri 5 str. 8401 regulator YP_691226.1 4015797 D 373384 CDS YP_691227.1 110807707 4210580 4016881..4017384 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4017384 insB 4210580 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691227.1 4016881 D 373384 CDS YP_691228.1 110807708 4210581 complement(4017592..4018416) 1 NC_008258.1 Code: S; COG: COG2861; hypothetical protein 4018416 yibQ 4210581 yibQ Shigella flexneri 5 str. 8401 hypothetical protein YP_691228.1 4017592 R 373384 CDS YP_691229.2 229774926 4210582 complement(4018555..4019838) 1 NC_008258.1 Code: D; COG: COG4942; hypothetical protein 4019838 yibP 4210582 yibP Shigella flexneri 5 str. 8401 hypothetical protein YP_691229.2 4018555 R 373384 CDS YP_691230.2 162139318 4210583 complement(4019848..4021392) 1 NC_008258.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4021392 yibO 4210583 yibO Shigella flexneri 5 str. 8401 phosphoglyceromutase YP_691230.2 4019848 R 373384 CDS YP_691231.1 110807711 4210584 complement(4021526..4022029) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4022029 insB 4210584 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691231.1 4021526 R 373384 CDS YP_691232.1 110807712 4210585 4022104..4022385 1 NC_008258.1 IS1 encoded protein 4022385 4210585 SFV_3919 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691232.1 4022104 D 373384 CDS YP_691233.1 110807713 4210586 4022413..4022844 1 NC_008258.1 Code: P; COG: COG0607; hypothetical protein 4022844 yibN 4210586 yibN Shigella flexneri 5 str. 8401 hypothetical protein YP_691233.1 4022413 D 373384 CDS YP_691234.1 110807714 4210587 4022986..4023237 1 NC_008258.1 Code: O; COG: COG0695; glutaredoxin 3 4023237 grxC 4210587 grxC Shigella flexneri 5 str. 8401 glutaredoxin 3 YP_691234.1 4022986 D 373384 CDS YP_691235.1 110807715 4210588 4023300..4023767 1 NC_008258.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 4023767 secB 4210588 secB Shigella flexneri 5 str. 8401 preprotein translocase subunit SecB YP_691235.1 4023300 D 373384 CDS YP_691236.1 110807716 4210589 4023767..4024786 1 NC_008258.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4024786 gpsA 4210589 gpsA Shigella flexneri 5 str. 8401 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_691236.1 4023767 D 373384 CDS YP_691237.1 110807717 4210590 4024866..4025687 1 NC_008258.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4025687 cysE 4210590 cysE Shigella flexneri 5 str. 8401 serine acetyltransferase YP_691237.1 4024866 D 373384 CDS YP_691238.1 110807718 4210591 complement(4025740..4026213) 1 NC_008258.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4026213 yibK 4210591 yibK Shigella flexneri 5 str. 8401 tRNA/rRNA methyltransferase YibK YP_691238.1 4025740 R 373384 CDS YP_691239.1 110807719 4210592 complement(4026409..4027599) 1 NC_008258.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4027599 lldD 4210592 lldD Shigella flexneri 5 str. 8401 L-lactate dehydrogenase YP_691239.1 4026409 R 373384 CDS YP_691240.1 110807720 4210593 complement(4027596..4028387) 1 NC_008258.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4028387 lldR 4210593 lldR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor LldR YP_691240.1 4027596 R 373384 CDS YP_691241.1 110807721 4210594 complement(4028372..4030027) 1 NC_008258.1 Code: C; COG: COG1620; L-lactate permease 4030027 lldP 4210594 lldP Shigella flexneri 5 str. 8401 L-lactate permease YP_691241.1 4028372 R 373384 CDS YP_691242.1 110807722 4210595 complement(4030395..4033088) 1 NC_008258.1 Code: UW; COG: COG5295; hypothetical protein 4033088 4210595 SFV_3929 Shigella flexneri 5 str. 8401 hypothetical protein YP_691242.1 4030395 R 373384 CDS YP_691243.1 110807723 4210596 complement(4033546..4034694) 1 NC_008258.1 adhesin 4034694 4210596 SFV_3930 Shigella flexneri 5 str. 8401 adhesin YP_691243.1 4033546 R 373384 CDS YP_691244.1 110807724 4209959 complement(4034738..4035421) 1 NC_008258.1 inner membrane lipoprotein 4035421 4209959 SFV_3931 Shigella flexneri 5 str. 8401 inner membrane lipoprotein YP_691244.1 4034738 R 373384 CDS YP_691245.1 110807725 4209960 complement(4035812..4036315) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4036315 insB 4209960 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691245.1 4035812 R 373384 CDS YP_691246.1 110807726 4209961 4036390..4036656 1 NC_008258.1 IS1 encoded protein 4036656 4209961 SFV_3933 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691246.1 4036390 D 373384 CDS YP_691247.1 110807727 4209962 complement(4036742..4037104) 1 NC_008258.1 hypothetical protein 4037104 yibL 4209962 yibL Shigella flexneri 5 str. 8401 hypothetical protein YP_691247.1 4036742 R 373384 CDS YP_691248.1 110807728 4209963 4037388..4037597 1 NC_008258.1 cytoplasmic protein 4037597 4209963 SFV_3935 Shigella flexneri 5 str. 8401 cytoplasmic protein YP_691248.1 4037388 D 373384 CDS YP_691249.1 110807729 4209964 complement(4037609..4038196) 1 NC_008258.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4038196 mtlR 4209964 mtlR Shigella flexneri 5 str. 8401 mannitol repressor protein YP_691249.1 4037609 R 373384 CDS YP_691250.1 110807730 4209965 complement(4038196..4039518) 1 NC_008258.1 Code: G; COG: COG0246; mannitol-1-phosphate 5-dehydrogenase 4039518 mtlD 4209965 mtlD Shigella flexneri 5 str. 8401 mannitol-1-phosphate 5-dehydrogenase YP_691250.1 4038196 R 373384 CDS YP_691251.1 110807731 4209966 complement(4039439..4041352) 1 NC_008258.1 Code: G; COG: COG2213; PTS system mannitol-specific transporter subunit IIABC 4041352 mtlA 4209966 mtlA Shigella flexneri 5 str. 8401 PTS system mannitol-specific transporter subunit IIABC YP_691251.1 4039439 R 373384 CDS YP_691252.1 110807732 4209967 4041889..4042251 1 NC_008258.1 hypothetical protein 4042251 yibI 4209967 yibI Shigella flexneri 5 str. 8401 hypothetical protein YP_691252.1 4041889 D 373384 CDS YP_691253.1 110807733 4209968 4042254..4043339 1 NC_008258.1 Code: V; COG: COG1566; hypothetical protein 4043339 yibH 4209968 yibH Shigella flexneri 5 str. 8401 hypothetical protein YP_691253.1 4042254 D 373384 CDS YP_691254.1 110807734 4209969 4043410..4044018 1 NC_008258.1 Code: O; COG: COG0625; glutathione S-transferase 4044018 yibF 4209969 yibF Shigella flexneri 5 str. 8401 glutathione S-transferase YP_691254.1 4043410 D 373384 CDS YP_691255.1 110807735 4209970 4044116..4045507 1 NC_008258.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4045507 selA 4209970 selA Shigella flexneri 5 str. 8401 selenocysteine synthase YP_691255.1 4044116 D 373384 CDS YP_691256.1 110807736 4209971 4045504..4047348 1 NC_008258.1 Code: J; COG: COG3276; selenocysteinyl-tRNA-specific translation factor 4047348 selB 4209971 selB Shigella flexneri 5 str. 8401 selenocysteinyl-tRNA-specific translation factor YP_691256.1 4045504 D 373384 CDS YP_691257.1 110807737 4209972 4047538..4048689 1 NC_008258.1 Code: C; COG: COG1454; alcohol dehydrogenase 4048689 yiaY 4209972 yiaY Shigella flexneri 5 str. 8401 alcohol dehydrogenase YP_691257.1 4047538 D 373384 CDS YP_691258.1 110807738 4209973 4048854..4050392 1 NC_008258.1 Code: C; COG: COG1012; lactaldehyde dehydrogenase 4050392 aldB 4209973 aldB Shigella flexneri 5 str. 8401 lactaldehyde dehydrogenase YP_691258.1 4048854 D 373384 CDS YP_691259.1 110807739 4209974 complement(4050611..4050823) 1 NC_008258.1 hypothetical protein 4050823 4209974 SFV_3946 Shigella flexneri 5 str. 8401 hypothetical protein YP_691259.1 4050611 R 373384 CDS YP_691260.1 110807740 4209975 4050907..4051260 1 NC_008258.1 hypothetical protein 4051260 yiaW 4209975 yiaW Shigella flexneri 5 str. 8401 hypothetical protein YP_691260.1 4050907 D 373384 CDS YP_691261.1 110807741 4209976 4051266..4052402 1 NC_008258.1 Code: V; COG: COG1566; hypothetical protein 4052402 yiaV 4209976 yiaV Shigella flexneri 5 str. 8401 hypothetical protein YP_691261.1 4051266 D 373384 CDS YP_691262.1 110807742 4209977 complement(4052399..4052713) 1 NC_008258.1 LysR family transcriptional regulator 4052713 4209977 SFV_3949 Shigella flexneri 5 str. 8401 LysR family transcriptional regulator YP_691262.1 4052399 R 373384 CDS YP_691263.1 110807743 4210879 complement(4052920..4053156) 1 NC_008258.1 IS1 encoded protein 4053156 4210879 SFV_3950 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691263.1 4052920 R 373384 CDS YP_691264.1 110807744 4210880 4053231..4053734 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4053734 insB 4210880 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691264.1 4053231 D 373384 CDS YP_691265.1 110807745 4210881 4054272..4055012 1 NC_008258.1 Code: M; COG: COG3713; outer membrane protein 4055012 yiaT 4210881 yiaT Shigella flexneri 5 str. 8401 outer membrane protein YP_691265.1 4054272 D 373384 CDS YP_691266.1 110807746 4210882 complement(4055133..4057112) 1 NC_008258.1 Code: S; COG: COG3533; hypothetical protein 4057112 4210882 SFV_3953 Shigella flexneri 5 str. 8401 hypothetical protein YP_691266.1 4055133 R 373384 CDS YP_691267.1 110807747 4210883 complement(4057123..4058523) 1 NC_008258.1 Code: G; COG: COG2211; permease 4058523 4210883 SFV_3954 Shigella flexneri 5 str. 8401 permease YP_691267.1 4057123 R 373384 CDS YP_691268.1 110807748 4210884 4058749..4059564 1 NC_008258.1 Code: K; COG: COG2207; transcriptional regulator 4059564 4210884 SFV_3955 Shigella flexneri 5 str. 8401 transcriptional regulator YP_691268.1 4058749 D 373384 CDS YP_691269.1 110807749 4210885 complement(4059596..4060291) 1 NC_008258.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4060291 sgbE 4210885 sgbE Shigella flexneri 5 str. 8401 L-ribulose-5-phosphate 4-epimerase YP_691269.1 4059596 R 373384 CDS YP_691270.1 110807750 4210886 complement(4060285..4061178) 1 NC_008258.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 4061178 sgbU 4210886 sgbU Shigella flexneri 5 str. 8401 L-xylulose 5-phosphate 3-epimerase YP_691270.1 4060285 R 373384 CDS YP_691271.1 110807751 4210887 complement(4061138..4061800) 1 NC_008258.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4061800 sgbH 4210887 sgbH Shigella flexneri 5 str. 8401 3-keto-L-gulonate-6-phosphate decarboxylase YP_691271.1 4061138 R 373384 CDS YP_691272.1 110807752 4210888 complement(4061797..4063293) 1 NC_008258.1 Code: G; COG: COG1070; L-xylulose kinase, cryptic 4063293 lyxK 4210888 lyxK Shigella flexneri 5 str. 8401 L-xylulose kinase, cryptic YP_691272.1 4061797 R 373384 CDS YP_691273.1 110807753 4210889 complement(4063297..4064283) 1 NC_008258.1 Code: G; COG: COG1638; solute-binding transport protein 4064283 yiaO 4210889 yiaO Shigella flexneri 5 str. 8401 solute-binding transport protein YP_691273.1 4063297 R 373384 CDS YP_691274.1 110807754 4210890 complement(4064296..4065573) 1 NC_008258.1 Code: G; COG: COG1593; hypothetical protein 4065573 yiaN 4210890 yiaN Shigella flexneri 5 str. 8401 hypothetical protein YP_691274.1 4064296 R 373384 CDS YP_691275.1 110807755 4210891 complement(4065576..4065878) 1 NC_008258.1 Code: G; COG: COG3090; hypothetical protein 4065878 yiaM 4210891 yiaM Shigella flexneri 5 str. 8401 hypothetical protein YP_691275.1 4065576 R 373384 CDS YP_691276.1 110807756 4210892 complement(4065908..4066411) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4066411 insB 4210892 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691276.1 4065908 R 373384 CDS YP_691277.1 110807757 4210893 4066486..4066674 1 NC_008258.1 IS1 encoded protein 4066674 4210893 SFV_3964 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691277.1 4066486 D 373384 CDS YP_691278.1 110807758 4210894 complement(4066820..4067812) 1 NC_008258.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4067812 yiaK 4210894 yiaK Shigella flexneri 5 str. 8401 2,3-diketo-L-gulonate reductase YP_691278.1 4066820 R 373384 CDS YP_691279.1 110807759 4210895 4068049..4068861 1 NC_008258.1 Code: K; COG: COG1414; regulator 4068861 yiaJ 4210895 yiaJ Shigella flexneri 5 str. 8401 regulator YP_691279.1 4068049 D 373384 CDS YP_691280.1 110807760 4210896 4068963..4069436 1 NC_008258.1 Code: C; COG: COG1142; hypothetical protein 4069436 yiaI 4210896 yiaI Shigella flexneri 5 str. 8401 hypothetical protein YP_691280.1 4068963 D 373384 CDS YP_691281.1 110807761 4210897 complement(4069587..4070945) 1 NC_008258.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4070945 avtA 4210897 avtA Shigella flexneri 5 str. 8401 valine--pyruvate transaminase YP_691281.1 4069587 R 373384 CDS YP_691282.1 110807762 4210898 complement(4071018..4073048) 1 NC_008258.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4073048 malS 4210898 malS Shigella flexneri 5 str. 8401 periplasmic alpha-amylase YP_691282.1 4071018 R 373384 CDS YP_691283.1 110807763 4208517 4073368..4074192 1 NC_008258.1 Code: R; COG: COG2992; hypothetical protein 4074192 bax 4208517 bax Shigella flexneri 5 str. 8401 hypothetical protein YP_691283.1 4073368 D 373384 CDS YP_691284.1 110807764 4208520 complement(4076715..4078256) 1 NC_008258.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4078256 xylG 4208520 xylG Shigella flexneri 5 str. 8401 xylose transporter ATP-binding subunit YP_691284.1 4076715 R 373384 CDS YP_691285.1 110807765 4208521 complement(4078334..4079404) 1 NC_008258.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4079404 xylF 4208521 xylF Shigella flexneri 5 str. 8401 D-xylose transporter subunit XylF YP_691285.1 4078334 R 373384 CDS YP_691286.1 110807766 4208523 4081049..4082503 1 NC_008258.1 Code: G; COG: COG1070; xylulokinase 4082503 xylB 4208523 xylB Shigella flexneri 5 str. 8401 xylulokinase YP_691286.1 4081049 D 373384 CDS YP_691287.1 110807767 4208524 4082672..4083013 1 NC_008258.1 Code: S; COG: COG4682; hypothetical protein 4083013 yiaB 4208524 yiaB Shigella flexneri 5 str. 8401 hypothetical protein YP_691287.1 4082672 D 373384 CDS YP_691288.1 110807768 4208525 4083059..4083496 1 NC_008258.1 Code: S; COG: COG4682; hypothetical protein 4083496 yiaA 4208525 yiaA Shigella flexneri 5 str. 8401 hypothetical protein YP_691288.1 4083059 D 373384 CDS YP_691289.1 110807769 4208526 complement(4083538..4084533) 1 NC_008258.1 Code: S; COG: COG3274; hypothetical protein 4084533 yiaH 4208526 yiaH Shigella flexneri 5 str. 8401 hypothetical protein YP_691289.1 4083538 R 373384 CDS YP_691290.1 110807770 4208527 4084707..4085006 1 NC_008258.1 lipoprotein 4085006 4208527 SFV_3980 Shigella flexneri 5 str. 8401 lipoprotein YP_691290.1 4084707 D 373384 CDS YP_691291.1 110807771 4208528 4085101..4086012 1 NC_008258.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4086012 glyQ 4208528 glyQ Shigella flexneri 5 str. 8401 glycyl-tRNA synthetase subunit alpha YP_691291.1 4085101 D 373384 CDS YP_691292.1 110807772 4208529 4086022..4088091 1 NC_008258.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4088091 glyS 4208529 glyS Shigella flexneri 5 str. 8401 glycyl-tRNA synthetase subunit beta YP_691292.1 4086022 D 373384 CDS YP_691293.1 110807773 4208530 complement(4088149..4088652) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4088652 insB 4208530 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691293.1 4088149 R 373384 CDS YP_691294.1 110807774 4208531 4088727..4088927 1 NC_008258.1 IS1 encoded protein 4088927 4208531 SFV_3984 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691294.1 4088727 D 373384 CDS YP_691295.1 110807775 4208532 4089067..4089363 1 NC_008258.1 hypothetical protein 4089363 4208532 SFV_3985 Shigella flexneri 5 str. 8401 hypothetical protein YP_691295.1 4089067 D 373384 CDS YP_691296.1 110807776 4208533 4089388..4092501 1 NC_008258.1 Code: V; COG: COG0841; transport system permease 4092501 yhiV 4208533 yhiV Shigella flexneri 5 str. 8401 transport system permease YP_691296.1 4089388 D 373384 CDS YP_691297.1 110807777 4208534 complement(4092864..4093592) 1 NC_008258.1 Code: K; COG: COG2207; AraC family transcriptional regulator 4093592 yhiW 4208534 yhiW Shigella flexneri 5 str. 8401 AraC family transcriptional regulator YP_691297.1 4092864 R 373384 CDS YP_691298.1 110807778 4208535 complement(4093960..4094784) 1 NC_008258.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 4094784 yhiX 4208535 yhiX Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator GadX YP_691298.1 4093960 R 373384 CDS YP_691299.1 110807779 4210501 complement(4095154..4096554) 1 NC_008258.1 Code: E; COG: COG0076; glutamate decarboxylase isozyme 4096554 gadA 4210501 gadA Shigella flexneri 5 str. 8401 glutamate decarboxylase isozyme YP_691299.1 4095154 R 373384 CDS YP_691300.1 110807780 4210502 complement(4096765..4098162) 1 NC_008258.1 Code: P; COG: COG1858; cytochrome C peroxidase 4098162 yhjA 4210502 yhjA Shigella flexneri 5 str. 8401 cytochrome C peroxidase YP_691300.1 4096765 R 373384 CDS YP_691301.1 110807781 4210503 complement(4098221..4098724) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4098724 insB 4210503 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691301.1 4098221 R 373384 CDS YP_691302.1 110807782 4210504 4098799..4098990 1 NC_008258.1 IS1 encoded protein 4098990 4210504 SFV_3992 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691302.1 4098799 D 373384 CDS YP_691303.1 110807783 4210505 4099227..4099526 1 NC_008258.1 Code: S; COG: COG3691; hypothetical protein 4099526 yiiS 4210505 yiiS Shigella flexneri 5 str. 8401 hypothetical protein YP_691303.1 4099227 D 373384 CDS YP_691304.1 110807784 4210506 4099553..4099981 1 NC_008258.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4099981 yiiT 4210506 yiiT Shigella flexneri 5 str. 8401 universal stress protein UspD YP_691304.1 4099553 D 373384 CDS YP_691305.1 110807785 4210507 complement(4099986..4100732) 1 NC_008258.1 Code: C; COG: COG1018; ferredoxin-NADP reductase 4100732 fpr 4210507 fpr Shigella flexneri 5 str. 8401 ferredoxin-NADP reductase YP_691305.1 4099986 R 373384 CDS YP_691306.1 110807786 4210508 complement(4100829..4101839) 1 NC_008258.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4101839 glpX 4210508 glpX Shigella flexneri 5 str. 8401 fructose 1,6-bisphosphatase II YP_691306.1 4100829 R 373384 CDS YP_691307.1 110807787 4210509 complement(4102069..4103514) 1 NC_008258.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4103514 glpK 4210509 glpK Shigella flexneri 5 str. 8401 glycerol kinase YP_691307.1 4102069 R 373384 CDS YP_691308.1 110807788 4210510 complement(4103800..4104444) 1 NC_008258.1 Code: G; COG: COG0580; glycerol diffusion facilitator protein 4104444 glpF 4210510 glpF Shigella flexneri 5 str. 8401 glycerol diffusion facilitator protein YP_691308.1 4103800 R 373384 CDS YP_691309.1 110807789 4210511 4104876..4105115 1 NC_008258.1 Code: S; COG: COG3074; hypothetical protein 4105115 yiiU 4210511 yiiU Shigella flexneri 5 str. 8401 hypothetical protein YP_691309.1 4104876 D 373384 CDS YP_691310.1 110807790 4210512 complement(4105200..4105685) 1 NC_008258.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4105685 menG 4210512 menG Shigella flexneri 5 str. 8401 ribonuclease activity regulator protein RraA YP_691310.1 4105200 R 373384 CDS YP_691311.1 110807791 4210513 complement(4105778..4106704) 1 NC_008258.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4106704 menA 4210513 menA Shigella flexneri 5 str. 8401 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_691311.1 4105778 R 373384 CDS YP_691312.1 110807792 4210514 complement(4106771..4108102) 1 NC_008258.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4108102 hslU 4210514 hslU Shigella flexneri 5 str. 8401 ATP-dependent protease ATP-binding subunit HslU YP_691312.1 4106771 R 373384 CDS YP_691313.1 110807793 4210515 complement(4108112..4108642) 1 NC_008258.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4108642 hslV 4210515 hslV Shigella flexneri 5 str. 8401 ATP-dependent protease peptidase subunit YP_691313.1 4108112 R 373384 CDS YP_691314.1 110807794 4210516 complement(4108735..4109694) 1 NC_008258.1 Code: D; COG: COG3087; essential cell division protein FtsN 4109694 ftsN 4210516 ftsN Shigella flexneri 5 str. 8401 essential cell division protein FtsN YP_691314.1 4108735 R 373384 CDS YP_691315.1 110807795 4210517 complement(4109786..4110748) 1 NC_008258.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4110748 cytR 4210517 cytR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator CytR YP_691315.1 4109786 R 373384 CDS YP_691316.1 110807796 4210518 complement(4110864..4113062) 1 NC_008258.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4113062 priA 4210518 priA Shigella flexneri 5 str. 8401 primosome assembly protein PriA YP_691316.1 4110864 R 373384 CDS YP_691317.1 110807797 4210519 complement(4113538..4114146) 1 NC_008258.1 member of the NlpC/P60 superfamily of peptidases; peptidoglycan peptidase 4114146 yiiX 4210519 yiiX Shigella flexneri 5 str. 8401 peptidoglycan peptidase YP_691317.1 4113538 R 373384 CDS YP_691318.1 110807798 4210520 complement(4114330..4114692) 1 NC_008258.1 repressor of all met genes but metF; when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4114692 metJ 4210520 metJ Shigella flexneri 5 str. 8401 transcriptional repressor protein MetJ YP_691318.1 4114330 R 373384 CDS YP_691319.1 110807799 4210424 4114780..4116084 1 NC_008258.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4116084 metB 4210424 metB Shigella flexneri 5 str. 8401 cystathionine gamma-synthase YP_691319.1 4114780 D 373384 CDS YP_691320.1 110807800 4210425 4116087..4118519 1 NC_008258.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4118519 metL 4210425 metL Shigella flexneri 5 str. 8401 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_691320.1 4116087 D 373384 CDS YP_691321.1 110807801 4210426 4118868..4119758 1 NC_008258.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4119758 metF 4210426 metF Shigella flexneri 5 str. 8401 5,10-methylenetetrahydrofolate reductase YP_691321.1 4118868 D 373384 CDS YP_691322.1 110807802 4210427 4120087..4122267 1 NC_008258.1 Code: P; COG: COG0376; catalase; hydroperoxidase HPI(I) 4122267 katG 4210427 katG Shigella flexneri 5 str. 8401 catalase; hydroperoxidase HPI(I) YP_691322.1 4120087 D 373384 CDS YP_691323.1 110807803 4210428 4122328..4123266 1 NC_008258.1 Code: GER; COG: COG0697; hypothetical protein 4123266 yijE 4210428 yijE Shigella flexneri 5 str. 8401 hypothetical protein YP_691323.1 4122328 D 373384 CDS YP_691324.1 110807804 4210429 complement(4123293..4123910) 1 NC_008258.1 Code: S; COG: COG3738; hypothetical protein 4123910 yijF 4210429 yijF Shigella flexneri 5 str. 8401 hypothetical protein YP_691324.1 4123293 R 373384 CDS YP_691325.1 110807805 4210433 4128781..4129860 1 NC_008258.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 4129860 frwC 4210433 frwC Shigella flexneri 5 str. 8401 fructose-like permease EIIC subunit 2 YP_691325.1 4128781 D 373384 CDS YP_691326.1 110807806 4210434 4129875..4130195 1 NC_008258.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 4130195 frwB 4210434 frwB Shigella flexneri 5 str. 8401 PTS system fructose-like transporter subunit EIIB YP_691326.1 4129875 D 373384 CDS YP_691327.1 110807807 4210435 4130246..4132543 1 NC_008258.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 4132543 pflD 4210435 pflD Shigella flexneri 5 str. 8401 formate acetyltransferase 2 YP_691327.1 4130246 D 373384 CDS YP_691328.1 110807808 4210436 4132509..4133387 1 NC_008258.1 Code: O; COG: COG1180; pyruvate formate lyase II activase 4133387 pflC 4210436 pflC Shigella flexneri 5 str. 8401 pyruvate formate lyase II activase YP_691328.1 4132509 D 373384 CDS YP_691329.1 110807809 4210437 4133389..4133730 1 NC_008258.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4133730 frwD 4210437 frwD Shigella flexneri 5 str. 8401 fructose-like phosphotransferase EIIB subunit 3 YP_691329.1 4133389 D 373384 CDS YP_691330.1 110807810 4210438 complement(4133717..4134568) 1 NC_008258.1 Code: K; COG: COG2207; AraC family transcriptional regulator 4134568 yijO 4210438 yijO Shigella flexneri 5 str. 8401 AraC family transcriptional regulator YP_691330.1 4133717 R 373384 CDS YP_691331.1 110807811 4210439 complement(4134717..4136450) 1 NC_008258.1 Code: R; COG: COG2194; hypothetical protein 4136450 yijP 4210439 yijP Shigella flexneri 5 str. 8401 hypothetical protein YP_691331.1 4134717 R 373384 CDS YP_691332.1 110807812 4210440 complement(4136633..4139284) 1 NC_008258.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4139284 ppc 4210440 ppc Shigella flexneri 5 str. 8401 phosphoenolpyruvate carboxylase YP_691332.1 4136633 R 373384 CDS YP_691333.1 110807813 4210441 complement(4139636..4140787) 1 NC_008258.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4140787 argE 4210441 argE Shigella flexneri 5 str. 8401 acetylornithine deacetylase YP_691333.1 4139636 R 373384 CDS YP_691334.1 110807814 4210442 4140941..4141945 1 NC_008258.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4141945 argC 4210442 argC Shigella flexneri 5 str. 8401 N-acetyl-gamma-glutamyl-phosphate reductase YP_691334.1 4140941 D 373384 CDS YP_691335.1 110807815 4210521 4141920..4142729 1 NC_008258.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4142729 argB 4210521 argB Shigella flexneri 5 str. 8401 acetylglutamate kinase YP_691335.1 4141920 D 373384 CDS YP_691336.1 110807816 4210522 4142790..4144163 1 NC_008258.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4144163 argH 4210522 argH Shigella flexneri 5 str. 8401 argininosuccinate lyase YP_691336.1 4142790 D 373384 CDS YP_691337.1 110807817 4210523 4144347..4145693 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 4145693 4210523 SFV_4030 Shigella flexneri 5 str. 8401 IS4 orf YP_691337.1 4144347 D 373384 CDS YP_691338.1 110807818 4210524 4146101..4147315 1 NC_008258.1 Code: MR; COG: COG4948; starvation-sensing protein 4147315 4210524 SFV_4031 Shigella flexneri 5 str. 8401 starvation-sensing protein YP_691338.1 4146101 D 373384 CDS YP_691339.1 110807819 4210526 4147997..4148500 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4148500 insB 4210526 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691339.1 4147997 D 373384 CDS YP_691340.1 110807820 4210527 4149696..4150613 1 NC_008258.1 activator, hydrogen peroxide-inducible genes; Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4150613 oxyR 4210527 oxyR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator OxyR YP_691340.1 4149696 D 373384 CDS YP_691341.1 110807821 4210528 complement(4150596..4151930) 1 NC_008258.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4151930 udhA 4210528 udhA Shigella flexneri 5 str. 8401 soluble pyridine nucleotide transhydrogenase YP_691341.1 4150596 R 373384 CDS YP_691342.1 110807822 4210529 4152104..4152967 1 NC_008258.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4152967 yijC 4210529 yijC Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor FabR YP_691342.1 4152104 D 373384 CDS YP_691343.1 110807823 4210530 4152967..4153326 1 NC_008258.1 hypothetical protein 4153326 yijD 4210530 yijD Shigella flexneri 5 str. 8401 hypothetical protein YP_691343.1 4152967 D 373384 CDS YP_691344.1 110807824 4210531 complement(4153366..4154466) 1 NC_008258.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4154466 trmA 4210531 trmA Shigella flexneri 5 str. 8401 tRNA (uracil-5-)-methyltransferase YP_691344.1 4153366 R 373384 CDS YP_691345.2 229774925 4210532 4154835..4156679 1 NC_008258.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4156679 btuB 4210532 btuB Shigella flexneri 5 str. 8401 vitamin B12/cobalamin outer membrane transporter YP_691345.2 4154835 D 373384 CDS YP_691346.1 110807826 4210533 4156624..4157481 1 NC_008258.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4157481 murI 4210533 murI Shigella flexneri 5 str. 8401 glutamate racemase YP_691346.1 4156624 D 373384 CDS YP_691347.1 110807827 4206937 4162994..4164022 1 NC_008258.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4164022 murB 4206937 murB Shigella flexneri 5 str. 8401 UDP-N-acetylenolpyruvoylglucosamine reductase YP_691347.1 4162994 D 373384 CDS YP_691348.1 110807828 4206938 4164019..4164984 1 NC_008258.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4164984 birA 4206938 birA Shigella flexneri 5 str. 8401 biotin--protein ligase YP_691348.1 4164019 D 373384 CDS YP_691349.1 110807829 4206939 complement(4165013..4166119) 1 NC_008258.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4166119 coaA 4206939 coaA Shigella flexneri 5 str. 8401 pantothenate kinase YP_691349.1 4165013 R 373384 CDS YP_691350.1 110807830 4206944 4166881..4168065 1 NC_008258.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4168065 tufB 4206944 tufB Shigella flexneri 5 str. 8401 elongation factor Tu YP_691350.1 4166881 D 373384 CDS YP_691351.1 110807831 4206945 4168295..4168678 1 NC_008258.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4168678 secE 4206945 secE Shigella flexneri 5 str. 8401 preprotein translocase subunit SecE YP_691351.1 4168295 D 373384 CDS YP_691352.1 110807832 4206946 4168680..4169225 1 NC_008258.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4169225 nusG 4206946 nusG Shigella flexneri 5 str. 8401 transcription antitermination protein NusG YP_691352.1 4168680 D 373384 CDS YP_691353.1 110807833 4206947 4169384..4169812 1 NC_008258.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4169812 rplK 4206947 rplK Shigella flexneri 5 str. 8401 50S ribosomal protein L11 YP_691353.1 4169384 D 373384 CDS YP_691354.1 110807834 4206948 4169816..4170520 1 NC_008258.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4170520 rplA 4206948 rplA Shigella flexneri 5 str. 8401 50S ribosomal protein L1 YP_691354.1 4169816 D 373384 CDS YP_691355.1 110807835 4206949 4170933..4171430 1 NC_008258.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4171430 rplJ 4206949 rplJ Shigella flexneri 5 str. 8401 50S ribosomal protein L10 YP_691355.1 4170933 D 373384 CDS YP_691356.1 110807836 4206950 4171497..4171862 1 NC_008258.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4171862 rplL 4206950 rplL Shigella flexneri 5 str. 8401 50S ribosomal protein L7/L12 YP_691356.1 4171497 D 373384 CDS YP_691357.1 110807837 4209193 4172182..4176210 1 NC_008258.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4176210 rpoB 4209193 rpoB Shigella flexneri 5 str. 8401 DNA-directed RNA polymerase subunit beta YP_691357.1 4172182 D 373384 CDS YP_691358.1 110807838 4209194 4176287..4180510 1 NC_008258.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4180510 rpoC 4209194 rpoC Shigella flexneri 5 str. 8401 DNA-directed RNA polymerase subunit beta' YP_691358.1 4176287 D 373384 CDS YP_691359.1 110807839 4209195 complement(4180752..4181885) 1 NC_008258.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4181885 thiH 4209195 thiH Shigella flexneri 5 str. 8401 thiamine biosynthesis protein ThiH YP_691359.1 4180752 R 373384 CDS YP_691360.2 162139317 4209197 complement(4181882..4182652) 1 NC_008258.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4182652 thiG 4209197 thiG Shigella flexneri 5 str. 8401 thiazole synthase YP_691360.2 4181882 R 373384 CDS YP_691361.1 110807840 4209196 complement(4182654..4182854) 1 NC_008258.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4182854 thiS 4209196 thiS Shigella flexneri 5 str. 8401 sulfur carrier protein ThiS YP_691361.1 4182654 R 373384 CDS YP_691362.1 110807842 4209198 complement(4182838..4183593) 1 NC_008258.1 Code: H; COG: COG0476; thiamine biosynthesis protein ThiF 4183593 thiF 4209198 thiF Shigella flexneri 5 str. 8401 thiamine biosynthesis protein ThiF YP_691362.1 4182838 R 373384 CDS YP_691363.1 110807843 4209199 complement(4183586..4184221) 1 NC_008258.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4184221 thiE 4209199 thiE Shigella flexneri 5 str. 8401 thiamine-phosphate pyrophosphorylase YP_691363.1 4183586 R 373384 CDS YP_691364.1 110807844 4209200 complement(4184221..4186116) 1 NC_008258.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4186116 thiC 4209200 thiC Shigella flexneri 5 str. 8401 thiamine biosynthesis protein ThiC YP_691364.1 4184221 R 373384 CDS YP_691365.1 110807845 4209201 complement(4186350..4186826) 1 NC_008258.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4186826 yjaE 4209201 yjaE Shigella flexneri 5 str. 8401 anti-RNA polymerase sigma 70 factor YP_691365.1 4186350 R 373384 CDS YP_691366.1 110807846 4209202 4186921..4187694 1 NC_008258.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4187694 nudC 4209202 nudC Shigella flexneri 5 str. 8401 NADH pyrophosphatase YP_691366.1 4186921 D 373384 CDS YP_691367.1 110807847 4209203 4187734..4188798 1 NC_008258.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4188798 hemE 4209203 hemE Shigella flexneri 5 str. 8401 uroporphyrinogen decarboxylase YP_691367.1 4187734 D 373384 CDS YP_691368.1 110807848 4209204 4188955..4189626 1 NC_008258.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4189626 nfi 4209204 nfi Shigella flexneri 5 str. 8401 endonuclease V YP_691368.1 4188955 D 373384 CDS YP_691369.1 110807849 4209205 4189669..4190259 1 NC_008258.1 Code: S; COG: COG3068; hypothetical protein 4190259 yjaG 4209205 yjaG Shigella flexneri 5 str. 8401 hypothetical protein YP_691369.1 4189669 D 373384 CDS YP_691370.1 110807850 4209206 4190446..4190718 1 NC_008258.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4190718 hupA 4209206 hupA Shigella flexneri 5 str. 8401 transcriptional regulator HU subunit alpha YP_691370.1 4190446 D 373384 CDS YP_691371.1 110807851 4209207 4190791..4191426 1 NC_008258.1 hypothetical protein 4191426 yjaH 4209207 yjaH Shigella flexneri 5 str. 8401 hypothetical protein YP_691371.1 4190791 D 373384 CDS YP_691372.1 110807852 4209208 complement(4191428..4191994) 1 NC_008258.1 Code: UNTP; COG: COG3678; zinc resistance protein 4191994 zraP 4209208 zraP Shigella flexneri 5 str. 8401 zinc resistance protein YP_691372.1 4191428 R 373384 CDS YP_691373.1 110807853 4209209 4192100..4193467 1 NC_008258.1 Code: T; COG: COG0642; sensor protein ZraS 4193467 hydH 4209209 hydH Shigella flexneri 5 str. 8401 sensor protein ZraS YP_691373.1 4192100 D 373384 CDS YP_691374.1 110807854 4209210 4193464..4194789 1 NC_008258.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4194789 hydG 4209210 hydG Shigella flexneri 5 str. 8401 transcriptional regulatory protein ZraR YP_691374.1 4193464 D 373384 CDS YP_691375.1 110807855 4209211 complement(4194786..4196075) 1 NC_008258.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4196075 purD 4209211 purD Shigella flexneri 5 str. 8401 phosphoribosylamine--glycine ligase YP_691375.1 4194786 R 373384 CDS YP_691376.1 110807856 4209212 complement(4196087..4197676) 1 NC_008258.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4197676 purH 4209212 purH Shigella flexneri 5 str. 8401 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_691376.1 4196087 R 373384 CDS YP_691377.1 110807857 4210922 complement(4203419..4203862) 1 NC_008258.1 Code: KR; COG: COG0454; hypothetical protein 4203862 yjaB 4210922 yjaB Shigella flexneri 5 str. 8401 hypothetical protein YP_691377.1 4203419 R 373384 CDS YP_691378.1 110807858 4210923 4204019..4204948 1 NC_008258.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4204948 metA 4210923 metA Shigella flexneri 5 str. 8401 homoserine O-succinyltransferase YP_691378.1 4204019 D 373384 CDS YP_691379.1 110807859 4210925 4206845..4208149 1 NC_008258.1 Code: C; COG: COG2224; isocitrate lyase 4208149 aceA 4210925 aceA Shigella flexneri 5 str. 8401 isocitrate lyase YP_691379.1 4206845 D 373384 CDS YP_691380.1 110807860 4210928 complement(4212540..4213364) 1 NC_008258.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; transcriptional repressor IclR 4213364 iclR 4210928 iclR Shigella flexneri 5 str. 8401 transcriptional repressor IclR YP_691380.1 4212540 R 373384 CDS YP_691381.1 110807861 4210929 4213564..4217247 1 NC_008258.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4217247 metH 4210929 metH Shigella flexneri 5 str. 8401 B12-dependent methionine synthase YP_691381.1 4213564 D 373384 CDS YP_691382.1 110807862 4210930 4217467..4219098 1 NC_008258.1 Code: P; COG: COG1283; alpha helix protein 4219098 yjbB 4210930 yjbB Shigella flexneri 5 str. 8401 alpha helix protein YP_691382.1 4217467 D 373384 CDS YP_691383.1 110807863 4210931 complement(4219189..4219878) 1 NC_008258.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4219878 pepE 4210931 pepE Shigella flexneri 5 str. 8401 peptidase E YP_691383.1 4219189 R 373384 CDS YP_691384.1 110807864 4210932 complement(4220260..4221489) 1 NC_008258.1 Code: ER; COG: COG1063; L-sorbose-1-P-reductase 4221489 sorE 4210932 sorE Shigella flexneri 5 str. 8401 L-sorbose-1-P-reductase YP_691384.1 4220260 R 373384 CDS YP_691385.1 110807865 4210953 complement(4221541..4222329) 1 NC_008258.1 Code: G; COG: COG3716; sorbose-permease PTS system IID component 4222329 sorM 4210953 sorM Shigella flexneri 5 str. 8401 sorbose-permease PTS system IID component YP_691385.1 4221541 R 373384 CDS YP_691386.1 110807866 4210954 complement(4222340..4223137) 1 NC_008258.1 Code: G; COG: COG3715; sorbose-permease PTS system IIC component 4223137 sorA 4210954 sorA Shigella flexneri 5 str. 8401 sorbose-permease PTS system IIC component YP_691386.1 4222340 R 373384 CDS YP_691387.1 110807867 4210955 complement(4223203..4223697) 1 NC_008258.1 Code: G; COG: COG3444; sorbose-permease PTS system IIB component 4223697 sorB 4210955 sorB Shigella flexneri 5 str. 8401 sorbose-permease PTS system IIB component YP_691387.1 4223203 R 373384 CDS YP_691388.1 110807868 4210956 complement(4223697..4224104) 1 NC_008258.1 Code: G; COG: COG2893; sorbose-permease PTS system IIA component 4224104 sorF 4210956 sorF Shigella flexneri 5 str. 8401 sorbose-permease PTS system IIA component YP_691388.1 4223697 R 373384 CDS YP_691389.1 110807869 4210957 complement(4224114..4224920) 1 NC_008258.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate; sorbitol-6-phosphate 2-dehydrogenase 4224920 sorD 4210957 sorD Shigella flexneri 5 str. 8401 sorbitol-6-phosphate 2-dehydrogenase YP_691389.1 4224114 R 373384 CDS YP_691390.1 110807870 4210958 complement(4224990..4225937) 1 NC_008258.1 Code: K; COG: COG2390; sor-operon regulator 4225937 4210958 SFV_4099 Shigella flexneri 5 str. 8401 sor-operon regulator YP_691390.1 4224990 R 373384 CDS YP_691391.1 110807871 4210959 4226285..4227157 1 NC_008258.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4227157 yjbC 4210959 yjbC Shigella flexneri 5 str. 8401 23S rRNA pseudouridine synthase F YP_691391.1 4226285 D 373384 CDS YP_691392.1 110807872 4210960 complement(4227290..4227508) 1 NC_008258.1 hypothetical protein 4227508 yjbD 4210960 yjbD Shigella flexneri 5 str. 8401 hypothetical protein YP_691392.1 4227290 R 373384 CDS YP_691393.1 110807873 4210961 complement(4227483..4227749) 1 NC_008258.1 IS2 ORF2 4227749 4210961 SFV_4102 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_691393.1 4227483 R 373384 CDS YP_691394.1 110807874 4210962 complement(4227804..4228322) 1 NC_008258.1 IS2 ORF2 4228322 4210962 SFV_4103 Shigella flexneri 5 str. 8401 IS2 ORF2 YP_691394.1 4227804 R 373384 CDS YP_691395.1 110807875 4210963 complement(4228346..4228711) 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4228711 4210963 SFV_4104 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_691395.1 4228346 R 373384 CDS YP_691396.1 110807876 4210964 4229126..4230757 1 NC_008258.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4230757 yjdH 4210964 yjdH Shigella flexneri 5 str. 8401 sensory histidine kinase DcuS YP_691396.1 4229126 D 373384 CDS YP_691397.1 110807877 4210965 4230754..4231473 1 NC_008258.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4231473 yjdG 4210965 yjdG Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator DcuR YP_691397.1 4230754 D 373384 CDS YP_691398.1 110807878 4210966 4232045..4233385 1 NC_008258.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4233385 dcuB 4210966 dcuB Shigella flexneri 5 str. 8401 anaerobic C4-dicarboxylate transporter YP_691398.1 4232045 D 373384 CDS YP_691399.1 110807879 4210967 4233463..4235109 1 NC_008258.1 Code: C; COG: COG1951; fumarate hydratase class I, anaerobic 4235109 fumB 4210967 fumB Shigella flexneri 5 str. 8401 fumarate hydratase class I, anaerobic YP_691399.1 4233463 D 373384 CDS YP_691400.1 110807880 4210968 4235232..4235861 1 NC_008258.1 Code: S; COG: COG3647; hypothetical protein 4235861 yjdF 4210968 yjdF Shigella flexneri 5 str. 8401 hypothetical protein YP_691400.1 4235232 D 373384 CDS YP_691401.1 110807881 4210969 complement(4236000..4237409) 1 NC_008258.1 Code: G; COG: COG2211; melibiose:sodium symporter 4237409 melB 4210969 melB Shigella flexneri 5 str. 8401 melibiose:sodium symporter YP_691401.1 4236000 R 373384 CDS YP_691402.1 110807882 4210970 complement(4237524..4238879) 1 NC_008258.1 Code: G; COG: COG1486; alpha-galactosidase 4238879 melA 4210970 melA Shigella flexneri 5 str. 8401 alpha-galactosidase YP_691402.1 4237524 R 373384 CDS YP_691403.1 110807883 4210971 4239162..4240070 1 NC_008258.1 Code: K; COG: COG2207; DNA-binding transcriptional regulator MelR 4240070 melR 4210971 melR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator MelR YP_691403.1 4239162 D 373384 CDS YP_691404.1 110807884 4210972 4240269..4242536 1 NC_008258.1 Code: E; COG: COG1982; biodegradative arginine decarboxylase 4242536 adiA 4210972 adiA Shigella flexneri 5 str. 8401 biodegradative arginine decarboxylase YP_691404.1 4240269 D 373384 CDS YP_691405.1 110807885 4209978 4242861..4243622 1 NC_008258.1 Code: K; COG: COG2207; AraC family transcriptional regulator 4243622 adiY 4209978 adiY Shigella flexneri 5 str. 8401 AraC family transcriptional regulator YP_691405.1 4242861 D 373384 CDS YP_691406.1 110807886 4209979 4243759..4245096 1 NC_008258.1 Code: E; COG: COG0531; arginine:agmatin antiporter 4245096 yjdE 4209979 yjdE Shigella flexneri 5 str. 8401 arginine:agmatin antiporter YP_691406.1 4243759 D 373384 CDS YP_691407.1 110807887 4209980 4245251..4246843 1 NC_008258.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 4246843 yjdB 4209980 yjdB Shigella flexneri 5 str. 8401 cell division protein YP_691407.1 4245251 D 373384 CDS YP_691408.1 110807888 4209981 4246840..4247508 1 NC_008258.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4247508 basR 4209981 basR Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator BasR YP_691408.1 4246840 D 373384 CDS YP_691409.1 110807889 4209982 4247518..4248609 1 NC_008258.1 Code: T; COG: COG0642; sensor protein BasS/PmrB 4248609 basS 4209982 basS Shigella flexneri 5 str. 8401 sensor protein BasS/PmrB YP_691409.1 4247518 D 373384 CDS YP_691410.1 110807890 4209983 complement(4248786..4250288) 1 NC_008258.1 Code: GEPR; COG: COG0477; proline/glycine betaine transporter 4250288 proP 4209983 proP Shigella flexneri 5 str. 8401 proline/glycine betaine transporter YP_691410.1 4248786 R 373384 CDS YP_691411.1 110807891 4209984 complement(4250552..4251430) 1 NC_008258.1 hypothetical protein 4251430 yjcZ 4209984 yjcZ Shigella flexneri 5 str. 8401 hypothetical protein YP_691411.1 4250552 R 373384 CDS YP_691412.1 110807892 4209985 complement(4251427..4253655) 1 NC_008258.1 hypothetical protein 4253655 yjdA 4209985 yjdA Shigella flexneri 5 str. 8401 hypothetical protein YP_691412.1 4251427 R 373384 CDS YP_691413.1 110807893 4209986 4253910..4254392 1 NC_008258.1 Code: P; COG: COG2824; hypothetical protein 4254392 phnA 4209986 phnA Shigella flexneri 5 str. 8401 hypothetical protein YP_691413.1 4253910 D 373384 CDS YP_691414.1 110807894 4209987 4254550..4254993 1 NC_008258.1 Code: S; COG: COG2764; hypothetical protein 4254993 phnB 4209987 phnB Shigella flexneri 5 str. 8401 hypothetical protein YP_691414.1 4254550 D 373384 CDS YP_691415.1 110807895 4209988 4255126..4255914 1 NC_008258.1 Code: P; COG: COG3638; phosphonate/organophosphate ester transporter subunit 4255914 phnC 4209988 phnC Shigella flexneri 5 str. 8401 phosphonate/organophosphate ester transporter subunit YP_691415.1 4255126 D 373384 CDS YP_691416.1 110807896 4209989 4255939..4256955 1 NC_008258.1 Code: P; COG: COG3221; periplasmic binding protein component of phosphonate transporter 4256955 phnD 4209989 phnD Shigella flexneri 5 str. 8401 periplasmic binding protein component of phosphonate transporter YP_691416.1 4255939 D 373384 CDS YP_691417.1 110807897 4209990 4257007..4257234 1 NC_008258.1 membrane channel protein component of phosphonate transporter 4257234 phnE 4209990 phnE Shigella flexneri 5 str. 8401 membrane channel protein component of phosphonate transporter YP_691417.1 4257007 D 373384 CDS YP_691418.1 110807898 4209991 complement(4257228..4257731) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4257731 insB 4209991 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691418.1 4257228 R 373384 CDS YP_691419.1 110807899 4209992 4257824..4258126 1 NC_008258.1 IS1 encoded protein 4258126 4209992 SFV_4128 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691419.1 4257824 D 373384 CDS YP_691420.1 110807900 4209993 4258152..4259123 1 NC_008258.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4259123 yjcR 4209993 yjcR Shigella flexneri 5 str. 8401 multidrug resistance protein MdtN YP_691420.1 4258152 D 373384 CDS YP_691421.1 110807901 4209994 4259123..4261165 1 NC_008258.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4261165 yjcQ 4209994 yjcQ Shigella flexneri 5 str. 8401 multidrug efflux system protein MdtO YP_691421.1 4259123 D 373384 CDS YP_691422.1 110807902 4209995 4261162..4262628 1 NC_008258.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP 4262628 yjcP 4209995 yjcP Shigella flexneri 5 str. 8401 outer membrane efflux protein MdtP YP_691422.1 4261162 D 373384 CDS YP_691423.1 110807903 4208282 4265067..4265756 1 NC_008258.1 Code: R; COG: COG0790; hypothetical protein 4265756 yjcO 4208282 yjcO Shigella flexneri 5 str. 8401 hypothetical protein YP_691423.1 4265067 D 373384 CDS YP_691424.1 110807904 4208283 complement(4265834..4267147) 1 NC_008258.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4267147 gltP 4208283 gltP Shigella flexneri 5 str. 8401 glutamate/aspartate:proton symporter YP_691424.1 4265834 R 373384 CDS YP_691425.1 110807905 4208284 complement(4267489..4268085) 1 NC_008258.1 Code: O; COG: COG4235; formate-dependent nitrite reductase complex subunit NrfG 4268085 nrfG 4208284 nrfG Shigella flexneri 5 str. 8401 formate-dependent nitrite reductase complex subunit NrfG YP_691425.1 4267489 R 373384 CDS YP_691426.1 110807906 4208285 complement(4268082..4268465) 1 NC_008258.1 Code: O; COG: COG3088; formate-dependent nitrite reductase complex subunit NrfF 4268465 nrfF 4208285 nrfF Shigella flexneri 5 str. 8401 formate-dependent nitrite reductase complex subunit NrfF YP_691426.1 4268082 R 373384 CDS YP_691427.1 110807907 4208286 complement(4268458..4270062) 1 NC_008258.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4270062 nrfE 4208286 nrfE Shigella flexneri 5 str. 8401 heme lyase subunit NrfE YP_691427.1 4268458 R 373384 CDS YP_691428.1 110807908 4208287 complement(4270196..4271152) 1 NC_008258.1 Code: P; COG: COG3301; formate-dependent nitrate reductase, transmembrane protein 4271152 nrfD 4208287 nrfD Shigella flexneri 5 str. 8401 formate-dependent nitrate reductase, transmembrane protein YP_691428.1 4270196 R 373384 CDS YP_691429.1 110807909 4208288 complement(4271149..4271820) 1 NC_008258.1 Code: C; COG: COG0437; formate-dependent nitrite reductase 4271820 nrfC 4208288 nrfC Shigella flexneri 5 str. 8401 formate-dependent nitrite reductase YP_691429.1 4271149 R 373384 CDS YP_691430.1 110807910 4208289 complement(4271817..4272383) 1 NC_008258.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4272383 nrfB 4208289 nrfB Shigella flexneri 5 str. 8401 cytochrome c nitrite reductase pentaheme subunit YP_691430.1 4271817 R 373384 CDS YP_691431.1 110807911 4208290 complement(4272428..4273897) 1 NC_008258.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4273897 nrfA 4208290 nrfA Shigella flexneri 5 str. 8401 cytochrome c552 YP_691431.1 4272428 R 373384 CDS YP_691432.1 110807912 4208291 4274257..4276215 1 NC_008258.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4276215 acs 4208291 acs Shigella flexneri 5 str. 8401 acetyl-CoA synthetase YP_691432.1 4274257 D 373384 CDS YP_691433.1 110807913 4208292 4276415..4276729 1 NC_008258.1 Code: S; COG: COG3162; hypothetical protein 4276729 yjcH 4208292 yjcH Shigella flexneri 5 str. 8401 hypothetical protein YP_691433.1 4276415 D 373384 CDS YP_691434.1 110807914 4208293 4276837..4278375 1 NC_008258.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4278375 actP 4208293 actP Shigella flexneri 5 str. 8401 acetate permease YP_691434.1 4276837 D 373384 CDS YP_691435.1 110807915 4208294 complement(4278642..4279145) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4279145 insB 4208294 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691435.1 4278642 R 373384 CDS YP_691436.1 110807916 4208295 4279220..4279429 1 NC_008258.1 IS1 encoded protein 4279429 4208295 SFV_4146 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691436.1 4279220 D 373384 CDS YP_691437.1 110807917 4208296 complement(4279702..4281351) 1 NC_008258.1 Code: P; COG: COG0025; hypothetical protein 4281351 yjcE 4208296 yjcE Shigella flexneri 5 str. 8401 hypothetical protein YP_691437.1 4279702 R 373384 CDS YP_691438.1 110807918 4208297 complement(4281502..4282851) 1 NC_008258.1 Code: R; COG: COG2252; hypothetical protein 4282851 yjcD 4208297 yjcD Shigella flexneri 5 str. 8401 hypothetical protein YP_691438.1 4281502 R 373384 CDS YP_691439.1 110807919 4208298 complement(4283557..4284021) 1 NC_008258.1 Code: K; COG: COG0789; redox-sensing activator of soxS 4284021 soxR 4208298 soxR Shigella flexneri 5 str. 8401 redox-sensing activator of soxS YP_691439.1 4283557 R 373384 CDS YP_691440.1 110807920 4208299 4284107..4284430 1 NC_008258.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4284430 soxS 4208299 soxS Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator SoxS YP_691440.1 4284107 D 373384 CDS YP_691441.1 110807921 4208300 complement(4284433..4286019) 1 NC_008258.1 Code: T; COG: COG4943; hypothetical protein 4286019 yjcC 4208300 yjcC Shigella flexneri 5 str. 8401 hypothetical protein YP_691441.1 4284433 R 373384 CDS YP_691442.1 110807922 4208301 4286379..4286729 1 NC_008258.1 hypothetical protein 4286729 yjcB 4208301 yjcB Shigella flexneri 5 str. 8401 hypothetical protein YP_691442.1 4286379 D 373384 CDS YP_691443.1 110807923 4209673 4286993..4287496 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4287496 insB 4209673 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691443.1 4286993 D 373384 CDS YP_691444.1 110807924 4209674 complement(4287604..4288140) 1 NC_008258.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4288140 ssb 4209674 ssb Shigella flexneri 5 str. 8401 single-stranded DNA-binding protein YP_691444.1 4287604 R 373384 CDS YP_691445.1 110807925 4209675 4288394..4291216 1 NC_008258.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4291216 uvrA 4209675 uvrA Shigella flexneri 5 str. 8401 excinuclease ABC subunit A YP_691445.1 4288394 D 373384 CDS YP_691446.1 110807926 4209676 complement(4291251..4291607) 1 NC_008258.1 Code: S; COG: COG2315; hypothetical protein 4291607 yjbR 4209676 yjbR Shigella flexneri 5 str. 8401 hypothetical protein YP_691446.1 4291251 R 373384 CDS YP_691447.1 110807927 4209677 complement(4291611..4292027) 1 NC_008258.1 Code: S; COG: COG0432; hypothetical protein 4292027 yjbQ 4209677 yjbQ Shigella flexneri 5 str. 8401 hypothetical protein YP_691447.1 4291611 R 373384 CDS YP_691448.1 110807928 4209678 complement(4292138..4293091) 1 NC_008258.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4293091 aphA 4209678 aphA Shigella flexneri 5 str. 8401 acid phosphatase/phosphotransferase YP_691448.1 4292138 R 373384 CDS YP_691449.1 110807929 4209679 complement(4293960..4295153) 1 NC_008258.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4295153 tyrB 4209679 tyrB Shigella flexneri 5 str. 8401 aromatic amino acid aminotransferase YP_691449.1 4293960 R 373384 CDS YP_691450.1 110807930 4209680 complement(4295406..4296485) 1 NC_008258.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4296485 alr 4209680 alr Shigella flexneri 5 str. 8401 alanine racemase YP_691450.1 4295406 R 373384 CDS YP_691451.1 110807931 4209681 complement(4296538..4297845) 1 NC_008258.1 Code: L; COG: COG0305; replicative DNA helicase 4297845 dnaB 4209681 dnaB Shigella flexneri 5 str. 8401 replicative DNA helicase YP_691451.1 4296538 R 373384 CDS YP_691452.1 110807932 4209682 4298036..4299019 1 NC_008258.1 Code: CR; COG: COG0604; quinone oxidoreductase, NADPH-dependent 4299019 qor 4209682 qor Shigella flexneri 5 str. 8401 quinone oxidoreductase, NADPH-dependent YP_691452.1 4298036 D 373384 CDS YP_691453.1 110807933 4209683 complement(4299185..4299637) 1 NC_008258.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4299637 pspG 4209683 pspG Shigella flexneri 5 str. 8401 phage shock protein G YP_691453.1 4299185 R 373384 CDS YP_691454.1 110807934 4209684 complement(4299561..4300604) 1 NC_008258.1 Code: J; COG: COG0042; tRNA-dihydrouridine synthase A 4300604 yjbN 4209684 yjbN Shigella flexneri 5 str. 8401 tRNA-dihydrouridine synthase A YP_691454.1 4299561 R 373384 CDS YP_691455.1 110807935 4209685 complement(4300961..4301701) 1 NC_008258.1 hypothetical protein 4301701 yjbM 4209685 yjbM Shigella flexneri 5 str. 8401 hypothetical protein YP_691455.1 4300961 R 373384 CDS YP_691456.1 110807936 4209686 complement(4301692..4301946) 1 NC_008258.1 hypothetical protein 4301946 yjbL 4209686 yjbL Shigella flexneri 5 str. 8401 hypothetical protein YP_691456.1 4301692 R 373384 CDS YP_691457.1 110807937 4209687 4302204..4302779 1 NC_008258.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4302779 yjbK 4209687 yjbK Shigella flexneri 5 str. 8401 zinc uptake transcriptional repressor YP_691457.1 4302204 D 373384 CDS YP_691458.1 110807938 4209688 complement(4302821..4303030) 1 NC_008258.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 4303030 yjbJ 4209688 yjbJ Shigella flexneri 5 str. 8401 stress-response protein YP_691458.1 4302821 R 373384 CDS YP_691459.1 110807939 4209689 complement(4303146..4304525) 1 NC_008258.1 Code: V; COG: COG0534; DNA-damage-inducible SOS response protein 4304525 dinF 4209689 dinF Shigella flexneri 5 str. 8401 DNA-damage-inducible SOS response protein YP_691459.1 4303146 R 373384 CDS YP_691460.1 110807940 4209690 complement(4304544..4305152) 1 NC_008258.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4305152 lexA 4209690 lexA Shigella flexneri 5 str. 8401 LexA repressor YP_691460.1 4304544 R 373384 CDS YP_691461.1 110807941 4209691 complement(4305262..4305630) 1 NC_008258.1 Code: M; COG: COG0818; diacylglycerol kinase 4305630 dgkA 4209691 dgkA Shigella flexneri 5 str. 8401 diacylglycerol kinase YP_691461.1 4305262 R 373384 CDS YP_691462.2 162139316 4208071 4305801..4308224 1 NC_008258.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4308224 plsB 4208071 plsB Shigella flexneri 5 str. 8401 glycerol-3-phosphate acyltransferase YP_691462.2 4305801 D 373384 CDS YP_691463.1 110807943 4208072 complement(4308379..4309251) 1 NC_008258.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4309251 ubiA 4208072 ubiA Shigella flexneri 5 str. 8401 4-hydroxybenzoate octaprenyltransferase YP_691463.1 4308379 R 373384 CDS YP_691464.1 110807944 4208073 complement(4309264..4309872) 1 NC_008258.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4309872 ubiC 4208073 ubiC Shigella flexneri 5 str. 8401 chorismate pyruvate lyase YP_691464.1 4309264 R 373384 CDS YP_691465.1 110807945 4208074 complement(4309919..4310422) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4310422 insB 4208074 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691465.1 4309919 R 373384 CDS YP_691466.1 110807946 4208075 4310497..4310691 1 NC_008258.1 IS1 encoded protein 4310691 4208075 SFV_4176 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691466.1 4310497 D 373384 CDS YP_691467.1 110807947 4208076 complement(4310805..4311725) 1 NC_008258.1 maltose regulon periplasmic protein 4311725 malM 4208076 malM Shigella flexneri 5 str. 8401 maltose regulon periplasmic protein YP_691467.1 4310805 R 373384 CDS YP_691468.1 110807948 4208077 complement(4311877..4313217) 1 NC_008258.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4313217 lamB 4208077 lamB Shigella flexneri 5 str. 8401 maltoporin YP_691468.1 4311877 R 373384 CDS YP_691469.1 110807949 4208078 complement(4313289..4314404) 1 NC_008258.1 with malEFG is involved in import of maltose/maltodextrin; maltose ABC transporter ATP-binding protein 4314404 malK 4208078 malK Shigella flexneri 5 str. 8401 maltose ABC transporter ATP-binding protein YP_691469.1 4313289 R 373384 CDS YP_691470.1 110807950 4208079 4314769..4315959 1 NC_008258.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter substrate-binding protein 4315959 malE 4208079 malE Shigella flexneri 5 str. 8401 maltose ABC transporter substrate-binding protein YP_691470.1 4314769 D 373384 CDS YP_691471.1 110807951 4208080 4316021..4317565 1 NC_008258.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4317565 malF 4208080 malF Shigella flexneri 5 str. 8401 maltose transporter membrane protein YP_691471.1 4316021 D 373384 CDS YP_691472.1 110807952 4208081 4317580..4318470 1 NC_008258.1 with MalKFE is involved in the transport of maltose into the cell; maltose ABC transporter permease 4318470 malG 4208081 malG Shigella flexneri 5 str. 8401 maltose ABC transporter permease YP_691472.1 4317580 D 373384 CDS YP_691473.1 110807953 4208083 complement(4320362..4320772) 1 NC_008258.1 Code: S; COG: COG3223; phosphate-starvation-inducible protein PsiE 4320772 yjbA 4208083 yjbA Shigella flexneri 5 str. 8401 phosphate-starvation-inducible protein PsiE YP_691473.1 4320362 R 373384 CDS YP_691474.1 110807954 4208084 complement(4321367..4323463) 1 NC_008258.1 hypothetical protein 4323463 yjbH 4208084 yjbH Shigella flexneri 5 str. 8401 hypothetical protein YP_691474.1 4321367 R 373384 CDS YP_691475.1 110807955 4208085 complement(4323579..4324220) 1 NC_008258.1 hypothetical protein 4324220 yjbG 4208085 yjbG Shigella flexneri 5 str. 8401 hypothetical protein YP_691475.1 4323579 R 373384 CDS YP_691476.1 110807956 4208086 complement(4324217..4324855) 1 NC_008258.1 hypothetical protein 4324855 yjbF 4208086 yjbF Shigella flexneri 5 str. 8401 hypothetical protein YP_691476.1 4324217 R 373384 CDS YP_691477.1 110807957 4208087 complement(4325673..4327322) 1 NC_008258.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4327322 pgi 4208087 pgi Shigella flexneri 5 str. 8401 glucose-6-phosphate isomerase YP_691477.1 4325673 R 373384 CDS YP_691478.1 110807958 4208088 4327847..4329196 1 NC_008258.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 4329196 lysC 4208088 lysC Shigella flexneri 5 str. 8401 aspartate kinase YP_691478.1 4327847 D 373384 CDS YP_691479.1 110807959 4208089 complement(4329362..4330963) 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF3 4330963 4208089 SFV_4190 Shigella flexneri 5 str. 8401 ISSfl4 ORF3 YP_691479.1 4329362 R 373384 CDS YP_691480.1 110807960 4208090 complement(4330983..4331330) 1 NC_008258.1 Code: L; COG: COG3436; ISSfl4 ORF2 4331330 4208090 SFV_4191 Shigella flexneri 5 str. 8401 ISSfl4 ORF2 YP_691480.1 4330983 R 373384 CDS YP_691481.1 110807961 4208836 complement(4331327..4332001) 1 NC_008258.1 ISSfl4 ORF1 4332001 4208836 SFV_4192 Shigella flexneri 5 str. 8401 ISSfl4 ORF1 YP_691481.1 4331327 R 373384 CDS YP_691482.1 110807962 4208837 4332161..4332526 1 NC_008258.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats; insertion sequence 2 OrfA protein 4332526 4208837 SFV_4193 Shigella flexneri 5 str. 8401 insertion sequence 2 OrfA protein YP_691482.1 4332161 D 373384 CDS YP_691483.2 162139315 4208838 4332484..4333389 1 NC_008258.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats; insertion element IS2 transposase InsD 4333389 4208838 SFV_4194 Shigella flexneri 5 str. 8401 insertion element IS2 transposase InsD YP_691483.2 4332484 D 373384 CDS YP_691484.1 110807964 4208839 complement(4333588..4334223) 1 NC_008258.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 4334223 yjiI 4208839 yjiI Shigella flexneri 5 str. 8401 RNA 2'-phosphotransferase-like protein YP_691484.1 4333588 R 373384 CDS YP_691485.1 110807965 4208840 4334422..4335105 1 NC_008258.1 Code: S; COG: COG3314; hypothetical protein 4335105 yjiH 4208840 yjiH Shigella flexneri 5 str. 8401 hypothetical protein YP_691485.1 4334422 D 373384 CDS YP_691486.1 110807966 4208841 4335102..4335563 1 NC_008258.1 Code: S; COG: COG0700; hypothetical protein 4335563 yjiG 4208841 yjiG Shigella flexneri 5 str. 8401 hypothetical protein YP_691486.1 4335102 D 373384 CDS YP_691487.1 110807967 4208842 4335576..4336748 1 NC_008258.1 isoaspartyl dipeptidase 4336748 iadA 4208842 iadA Shigella flexneri 5 str. 8401 isoaspartyl dipeptidase YP_691487.1 4335576 D 373384 CDS YP_691488.1 110807968 4208843 4336813..4337724 1 NC_008258.1 Code: K; COG: COG0583; DNA-binding transcriptional regulator 4337724 yjiE 4208843 yjiE Shigella flexneri 5 str. 8401 DNA-binding transcriptional regulator YP_691488.1 4336813 D 373384 CDS YP_691489.1 110807969 4208844 complement(4337717..4338106) 1 NC_008258.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 4338106 iraD 4208844 iraD Shigella flexneri 5 str. 8401 DNA replication/recombination/repair protein YP_691489.1 4337717 R 373384 CDS YP_691490.1 110807970 4208845 4338782..4339612 1 NC_008258.1 hypothetical protein 4339612 yjiC 4208845 yjiC Shigella flexneri 5 str. 8401 hypothetical protein YP_691490.1 4338782 D 373384 CDS YP_691491.1 110807971 4208846 complement(4339753..4340478) 1 NC_008258.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 4340478 uxuR 4208846 uxuR Shigella flexneri 5 str. 8401 DNA-binding transcriptional repressor UxuR YP_691491.1 4339753 R 373384 CDS YP_691492.1 110807972 4208847 complement(4340741..4342201) 1 NC_008258.1 Code: G; COG: COG0246; D-mannonate oxidoreductase 4342201 uxuB 4208847 uxuB Shigella flexneri 5 str. 8401 D-mannonate oxidoreductase YP_691492.1 4340741 R 373384 CDS YP_691493.1 110807973 4208848 complement(4342282..4343466) 1 NC_008258.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 4343466 uxuA 4208848 uxuA Shigella flexneri 5 str. 8401 mannonate dehydratase YP_691493.1 4342282 R 373384 CDS YP_691494.1 110807974 4208849 4343806..4345149 1 NC_008258.1 Code: GE; COG: COG2610; fructuronate transporter 4345149 gntP 4208849 gntP Shigella flexneri 5 str. 8401 fructuronate transporter YP_691494.1 4343806 D 373384 CDS YP_691495.1 110807975 4208850 complement(4345400..4346302) 1 NC_008258.1 FimH protein 4346302 fimH 4208850 fimH Shigella flexneri 5 str. 8401 FimH protein YP_691495.1 4345400 R 373384 CDS YP_691496.1 110807976 4208851 complement(4346322..4346825) 1 NC_008258.1 Code: NU; COG: COG3539; minor fimbrial subunit 4346825 fimG 4208851 fimG Shigella flexneri 5 str. 8401 minor fimbrial subunit YP_691496.1 4346322 R 373384 CDS YP_691497.1 110807977 4208852 complement(4346838..4347368) 1 NC_008258.1 Code: NU; COG: COG3539; minor fimbrial subunit 4347368 fimF 4208852 fimF Shigella flexneri 5 str. 8401 minor fimbrial subunit YP_691497.1 4346838 R 373384 CDS YP_691498.1 110807978 4208853 complement(4347378..4350014) 1 NC_008258.1 Code: NU; COG: COG3188; Outer membrane usher protein fimD 4350014 fimD 4208853 fimD Shigella flexneri 5 str. 8401 Outer membrane usher protein fimD YP_691498.1 4347378 R 373384 CDS YP_691499.1 110807979 4208854 complement(4350081..4350737) 1 NC_008258.1 Code: NU; COG: COG3121; periplasmic chaperone 4350737 fimC 4208854 fimC Shigella flexneri 5 str. 8401 periplasmic chaperone YP_691499.1 4350081 R 373384 CDS YP_691500.1 110807980 4210899 4351653..4352156 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4352156 insB 4210899 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691500.1 4351653 D 373384 CDS YP_691501.1 110807981 4210901 complement(4352224..4352772) 1 NC_008258.1 Code: NU; COG: COG3539; major type 1 subunit fimbrin (pilin) 4352772 fimA 4210901 fimA Shigella flexneri 5 str. 8401 major type 1 subunit fimbrin (pilin) YP_691501.1 4352224 R 373384 CDS YP_691502.1 110807982 4210902 complement(4353253..4353807) 1 NC_008258.1 inversion of on/off regulator of fimA; tyrosine recombinase 4353807 fimE 4210902 fimE Shigella flexneri 5 str. 8401 tyrosine recombinase YP_691502.1 4353253 R 373384 CDS YP_691503.1 110807983 4210903 complement(4354444..4354929) 1 NC_008258.1 Code: L; COG: COG0582; recombinase; regulator for fimA 4354929 fimB 4210903 fimB Shigella flexneri 5 str. 8401 recombinase; regulator for fimA YP_691503.1 4354444 R 373384 CDS YP_691504.1 110807984 4210904 4356383..4357099 1 NC_008258.1 hypothetical protein 4357099 yjhA 4210904 yjhA Shigella flexneri 5 str. 8401 hypothetical protein YP_691504.1 4356383 D 373384 CDS YP_691505.1 110807985 4210905 4357011..4358225 1 NC_008258.1 Code: S; COG: COG3055; N-acetylneuraminic acid mutarotase 4358225 yjhT 4210905 yjhT Shigella flexneri 5 str. 8401 N-acetylneuraminic acid mutarotase YP_691505.1 4357011 D 373384 CDS YP_691506.1 110807986 4210906 4358290..4359270 1 NC_008258.1 Code: L; COG: COG2801; hypothetical protein 4359270 yjhS 4210906 yjhS Shigella flexneri 5 str. 8401 hypothetical protein YP_691506.1 4358290 D 373384 CDS YP_691507.1 110807987 4210907 complement(4359739..4360242) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4360242 insB 4210907 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691507.1 4359739 R 373384 CDS YP_691508.1 110807988 4210908 4360317..4360583 1 NC_008258.1 IS1 encoded protein 4360583 4210908 SFV_4220 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691508.1 4360317 D 373384 CDS YP_691509.1 110807989 4210909 4360621..4361226 1 NC_008258.1 Code: KG; COG: COG1349; DeoR family transcriptional regulator 4361226 4210909 SFV_4221 Shigella flexneri 5 str. 8401 DeoR family transcriptional regulator YP_691509.1 4360621 D 373384 CDS YP_691510.1 110807990 4210910 complement(4361327..4361443) 1 NC_008258.1 hypothetical protein 4361443 4210910 SFV_4222 Shigella flexneri 5 str. 8401 hypothetical protein YP_691510.1 4361327 R 373384 CDS YP_691511.1 110807991 4210911 4361702..4361980 1 NC_008258.1 Code: L; COG: COG2963; ISEhe3 orfA 4361980 4210911 SFV_4223 Shigella flexneri 5 str. 8401 ISEhe3 orfA YP_691511.1 4361702 D 373384 CDS YP_691512.1 110807992 4210912 4362049..4362249 1 NC_008258.1 IS600 ORF1 4362249 4210912 SFV_4224 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_691512.1 4362049 D 373384 CDS YP_691513.1 110807993 4210913 complement(4362117..4362419) 1 NC_008258.1 IS1 encoded protein 4362419 4210913 SFV_4225 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691513.1 4362117 R 373384 CDS YP_691514.1 110807994 4210914 4362494..4362997 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4362997 insB 4210914 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691514.1 4362494 D 373384 CDS YP_691515.1 110807995 4210915 complement(4363338..4364531) 1 NC_008258.1 Code: L; COG: COG0582; P4-type integrase 4364531 4210915 SFV_4227 Shigella flexneri 5 str. 8401 P4-type integrase YP_691515.1 4363338 R 373384 CDS YP_691516.1 110807996 4210917 4365010..4366029 1 NC_008258.1 Code: R; COG: COG1064; oxidoreductase 4366029 yjgB 4210917 yjgB Shigella flexneri 5 str. 8401 oxidoreductase YP_691516.1 4365010 D 373384 CDS YP_691517.1 110807997 4206899 4366158..4367660 1 NC_008258.1 Code: R; COG: COG0433; hypothetical protein 4367660 yjgR 4206899 yjgR Shigella flexneri 5 str. 8401 hypothetical protein YP_691517.1 4366158 D 373384 CDS YP_691518.1 110807998 4206900 complement(4367779..4368861) 1 NC_008258.1 Code: R; COG: COG0795; hypothetical protein 4368861 yjgQ 4206900 yjgQ Shigella flexneri 5 str. 8401 hypothetical protein YP_691518.1 4367779 R 373384 CDS YP_691519.1 110807999 4206901 complement(4368861..4369898) 1 NC_008258.1 Code: R; COG: COG0795; hypothetical protein 4369898 yjgP 4206901 yjgP Shigella flexneri 5 str. 8401 hypothetical protein YP_691519.1 4368861 R 373384 CDS YP_691520.1 110808000 4206902 4370228..4371739 1 NC_008258.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4371739 pepA 4206902 pepA Shigella flexneri 5 str. 8401 leucyl aminopeptidase YP_691520.1 4370228 D 373384 CDS YP_691521.1 110808001 4206903 4371873..4372316 1 NC_008258.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4372316 holC 4206903 holC Shigella flexneri 5 str. 8401 DNA polymerase III subunit chi YP_691521.1 4371873 D 373384 CDS YP_691522.1 110808002 4206904 4372316..4375171 1 NC_008258.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4375171 valS 4206904 valS Shigella flexneri 5 str. 8401 valyl-tRNA synthetase YP_691522.1 4372316 D 373384 CDS YP_691523.1 110808003 4206905 complement(4375225..4376421) 1 NC_008258.1 Code: S; COG: COG4269; hypothetical protein 4376421 yjgN 4206905 yjgN Shigella flexneri 5 str. 8401 hypothetical protein YP_691523.1 4375225 R 373384 CDS YP_691524.1 110808004 4206906 4376614..4377117 1 NC_008258.1 Code: KR; COG: COG0454; hypothetical protein 4377117 4206906 SFV_4237 Shigella flexneri 5 str. 8401 hypothetical protein YP_691524.1 4376614 D 373384 CDS YP_691525.1 110808005 4206907 complement(4377163..4377579) 1 NC_008258.1 Code: S; COG: COG3076; hypothetical protein 4377579 yjgD 4206907 yjgD Shigella flexneri 5 str. 8401 hypothetical protein YP_691525.1 4377163 R 373384 CDS YP_691526.1 110808006 4206908 4377741..4378754 1 NC_008258.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4378754 argI 4206908 argI Shigella flexneri 5 str. 8401 ornithine carbamoyltransferase subunit I YP_691526.1 4377741 D 373384 CDS YP_691527.1 110808007 4206909 complement(4378760..4378945) 1 NC_008258.1 IS1 encoded protein 4378945 4206909 SFV_4240 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691527.1 4378760 R 373384 CDS YP_691528.1 110808008 4206910 4379020..4379523 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4379523 insB 4206910 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691528.1 4379020 D 373384 CDS YP_691529.1 110808009 4206911 complement(4379534..4380262) 1 NC_008258.1 hypothetical protein 4380262 4206911 SFV_4242 Shigella flexneri 5 str. 8401 hypothetical protein YP_691529.1 4379534 R 373384 CDS YP_691530.1 110808010 4206912 complement(4380385..4380837) 1 NC_008258.1 Code: G; COG: COG2731; hypothetical protein 4380837 yjgK 4206912 yjgK Shigella flexneri 5 str. 8401 hypothetical protein YP_691530.1 4380385 R 373384 CDS YP_691531.1 110808011 4206913 complement(4380982..4381575) 1 NC_008258.1 Code: K; COG: COG1309; hypothetical protein 4381575 yjgJ 4206913 yjgJ Shigella flexneri 5 str. 8401 hypothetical protein YP_691531.1 4380982 R 373384 CDS YP_691532.1 110808012 4206914 4381646..4382359 1 NC_008258.1 Code: IQR; COG: COG1028; oxidoreductase 4382359 yjgI 4206914 yjgI Shigella flexneri 5 str. 8401 oxidoreductase YP_691532.1 4381646 D 373384 CDS YP_691533.1 110808013 4206915 4382407..4382886 1 NC_008258.1 Code: J; COG: COG0251; hypothetical protein 4382886 yjgH 4206915 yjgH Shigella flexneri 5 str. 8401 hypothetical protein YP_691533.1 4382407 D 373384 CDS YP_691534.1 110808014 4206916 4383305..4384240 1 NC_008258.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 4384240 pyrB 4206916 pyrB Shigella flexneri 5 str. 8401 aspartate carbamoyltransferase YP_691534.1 4383305 D 373384 CDS YP_691535.1 110808015 4206917 4384253..4384714 1 NC_008258.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 4384714 pyrI 4206917 pyrI Shigella flexneri 5 str. 8401 aspartate carbamoyltransferase YP_691535.1 4384253 D 373384 CDS YP_691536.1 110808016 4210443 4384787..4385173 1 NC_008258.1 Code: J; COG: COG0251; hypothetical protein 4385173 yjgF 4210443 yjgF Shigella flexneri 5 str. 8401 hypothetical protein YP_691536.1 4384787 D 373384 CDS YP_691537.1 110808017 4210444 complement(4385379..4388075) 1 NC_008258.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4388075 mgtA 4210444 mgtA Shigella flexneri 5 str. 8401 magnesium-transporting ATPase MgtA YP_691537.1 4385379 R 373384 CDS YP_691538.1 110808018 4210445 4388454..4389401 1 NC_008258.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4389401 treR 4210445 treR Shigella flexneri 5 str. 8401 trehalose repressor YP_691538.1 4388454 D 373384 CDS YP_691539.1 110808019 4210446 4390844..4392646 1 NC_008258.1 Code: G; COG: COG0366; trehalose-6-phosphate hydrolase 4392646 treC 4210446 treC Shigella flexneri 5 str. 8401 trehalose-6-phosphate hydrolase YP_691539.1 4390844 D 373384 CDS YP_691540.1 110808020 4210447 4393040..4395178 1 NC_008258.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4395178 nrdD 4210447 nrdD Shigella flexneri 5 str. 8401 anaerobic ribonucleoside triphosphate reductase YP_691540.1 4393040 D 373384 CDS YP_691541.1 110808021 4210448 4395336..4395800 1 NC_008258.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4395800 nrdG 4210448 nrdG Shigella flexneri 5 str. 8401 anaerobic ribonucleotide reductase-activating protein YP_691541.1 4395336 D 373384 CDS YP_691542.1 110808022 4210449 complement(4395845..4396231) 1 NC_008258.1 Code: C; COG: COG3783; cytochrome b(562) 4396231 cybC 4210449 cybC Shigella flexneri 5 str. 8401 cytochrome b(562) YP_691542.1 4395845 R 373384 CDS YP_691543.1 110808023 4210450 complement(4396414..4397685) 1 NC_008258.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4397685 pmbA 4210450 pmbA Shigella flexneri 5 str. 8401 peptidase PmbA YP_691543.1 4396414 R 373384 CDS YP_691544.1 110808024 4210451 4397860..4398411 1 NC_008258.1 Code: S; COG: COG3028; hypothetical protein 4398411 yjgA 4210451 yjgA Shigella flexneri 5 str. 8401 hypothetical protein YP_691544.1 4397860 D 373384 CDS YP_691545.1 110808025 4210452 complement(4398494..4399816) 1 NC_008258.1 Code: M; COG: COG0773; ligase 4399816 yjfG 4210452 yjfG Shigella flexneri 5 str. 8401 ligase YP_691545.1 4398494 R 373384 CDS YP_691546.1 110808026 4210453 4400043..4401041 1 NC_008258.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4401041 fbp 4210453 fbp Shigella flexneri 5 str. 8401 fructose-1,6-bisphosphatase YP_691546.1 4400043 D 373384 CDS YP_691547.1 110808027 4210454 complement(4401079..4402425) 1 NC_008258.1 Code: L; COG: COG3385; IS4 orf 4402425 4210454 SFV_4260 Shigella flexneri 5 str. 8401 IS4 orf YP_691547.1 4401079 R 373384 CDS YP_691548.1 110808028 4210455 complement(4402635..4403507) 1 NC_008258.1 membrane component of a sugar ABC transporter system; ABC transporter permease 4403507 yjfF 4210455 yjfF Shigella flexneri 5 str. 8401 ABC transporter permease YP_691548.1 4402635 R 373384 CDS YP_691549.1 110808029 4210456 complement(4403494..4404516) 1 NC_008258.1 Code: G; COG: COG1172; transport system permease 4404516 ytfT 4210456 ytfT Shigella flexneri 5 str. 8401 transport system permease YP_691549.1 4403494 R 373384 CDS YP_691550.1 110808030 4210457 complement(4404530..4406032) 1 NC_008258.1 Code: G; COG: COG1129; ABC transporter ATP-binding protein 4406032 ytfR 4210457 ytfR Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_691550.1 4404530 R 373384 CDS YP_691551.1 110808031 4210459 4407438..4407968 1 NC_008258.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4407968 ppa 4210459 ppa Shigella flexneri 5 str. 8401 inorganic pyrophosphatase YP_691551.1 4407438 D 373384 CDS YP_691552.1 110808032 4210460 complement(4408347..4408688) 1 NC_008258.1 Code: S; COG: COG2105; hypothetical protein 4408688 ytfP 4210460 ytfP Shigella flexneri 5 str. 8401 hypothetical protein YP_691552.1 4408347 R 373384 CDS YP_691553.1 110808033 4210461 complement(4408691..4412470) 1 NC_008258.1 Code: S; COG: COG2911; hypothetical protein 4412470 ytfN 4210461 ytfN Shigella flexneri 5 str. 8401 hypothetical protein YP_691553.1 4408691 R 373384 CDS YP_691554.1 110808034 4210462 complement(4412467..4414200) 1 NC_008258.1 Code: M; COG: COG0729; hypothetical protein 4414200 ytfM 4210462 ytfM Shigella flexneri 5 str. 8401 hypothetical protein YP_691554.1 4412467 R 373384 CDS YP_691555.1 110808035 4210992 4414406..4415044 1 NC_008258.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4415044 msrA 4210992 msrA Shigella flexneri 5 str. 8401 methionine sulfoxide reductase A YP_691555.1 4414406 D 373384 CDS YP_691556.1 110808036 4210993 4415367..4416710 1 NC_008258.1 Code: R; COG: COG1253; transport protein 4416710 ytfL 4210993 ytfL Shigella flexneri 5 str. 8401 transport protein YP_691556.1 4415367 D 373384 CDS YP_691557.1 110808037 4210994 4417303..4417857 1 NC_008258.1 Code: R; COG: COG3054; hypothetical protein 4417857 ytfJ 4210994 ytfJ Shigella flexneri 5 str. 8401 hypothetical protein YP_691557.1 4417303 D 373384 CDS YP_691558.1 110808038 4210995 complement(4417920..4418858) 1 NC_008258.1 hypothetical protein 4418858 ytfI 4210995 ytfI Shigella flexneri 5 str. 8401 hypothetical protein YP_691558.1 4417920 R 373384 CDS YP_691559.1 110808039 4210996 complement(4419070..4419762) 1 NC_008258.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4419762 cysQ 4210996 cysQ Shigella flexneri 5 str. 8401 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_691559.1 4419070 R 373384 CDS YP_691560.1 110808040 4210997 4420000..4421943 1 NC_008258.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4421943 cpdB 4210997 cpdB Shigella flexneri 5 str. 8401 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_691560.1 4420000 D 373384 CDS YP_691561.1 110808042 4210999 complement(4422069..4422560) 1 NC_008258.1 Code: K; COG: COG1733; hypothetical protein 4422560 ytfH 4210999 ytfH Shigella flexneri 5 str. 8401 hypothetical protein YP_691561.1 4422069 R 373384 CDS YP_691562.1 110808041 4210998 4422538..4423398 1 NC_008258.1 Code: MG; COG: COG0702; oxidoreductase 4423398 ytfG 4210998 ytfG Shigella flexneri 5 str. 8401 oxidoreductase YP_691562.1 4422538 D 373384 CDS YP_691563.1 110808043 4211000 4423498..4424472 1 NC_008258.1 Code: GER; COG: COG0697; transmembrane subunit 4424472 ytfF 4211000 ytfF Shigella flexneri 5 str. 8401 transmembrane subunit YP_691563.1 4423498 D 373384 CDS YP_691564.1 110808044 4211001 4424580..4425242 1 NC_008258.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4425242 ytfE 4211001 ytfE Shigella flexneri 5 str. 8401 iron-sulfur cluster repair di-iron protein YP_691564.1 4424580 D 373384 CDS YP_691565.1 110808045 4211002 complement(4425287..4426699) 1 NC_008258.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4426699 cycA 4211002 cycA Shigella flexneri 5 str. 8401 D-alanine/D-serine/glycine permease YP_691565.1 4425287 R 373384 CDS YP_691566.1 110808046 4211003 complement(4427008..4427628) 1 NC_008258.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4427628 fklB 4211003 fklB Shigella flexneri 5 str. 8401 peptidyl-prolyl cis-trans isomerase YP_691566.1 4427008 R 373384 CDS YP_691567.1 110808047 4211004 4427847..4428392 1 NC_008258.1 Code: M; COG: COG3061; hypothetical protein 4428392 ytfB 4211004 ytfB Shigella flexneri 5 str. 8401 hypothetical protein YP_691567.1 4427847 D 373384 CDS YP_691568.1 110808048 4211005 complement(4428376..4429023) 1 NC_008258.1 hypothetical protein 4429023 ytfA 4211005 ytfA Shigella flexneri 5 str. 8401 hypothetical protein YP_691568.1 4428376 R 373384 CDS YP_691569.2 162139314 4211006 4429235..4430026 1 NC_008258.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 4430026 4211006 SFV_4283 Shigella flexneri 5 str. 8401 3-ketoacyl-ACP reductase YP_691569.2 4429235 D 373384 CDS YP_691570.1 110808050 4211007 4430171..4430920 1 NC_008258.1 Code: G; COG: COG1082; hypothetical protein 4430920 4211007 SFV_4284 Shigella flexneri 5 str. 8401 hypothetical protein YP_691570.1 4430171 D 373384 CDS YP_691571.1 110808051 4211008 complement(4430855..4431358) 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4431358 insB 4211008 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691571.1 4430855 R 373384 CDS YP_691572.1 110808052 4211009 4431472..4432428 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 4432428 4211009 SFV_4286 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_691572.1 4431472 D 373384 CDS YP_691573.1 110808053 4211010 complement(4432469..4433521) 1 NC_008258.1 Code: E; COG: COG0531; transport of lysine/cadaverine 4433521 cadB 4211010 cadB Shigella flexneri 5 str. 8401 transport of lysine/cadaverine YP_691573.1 4432469 R 373384 CDS YP_691574.1 110808054 4207585 complement(4433561..4433815) 1 NC_008258.1 IS1 encoded protein 4433815 4207585 SFV_4288 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691574.1 4433561 R 373384 CDS YP_691575.1 110808055 4207586 4433890..4434393 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4434393 insB 4207586 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691575.1 4433890 D 373384 CDS YP_691576.1 110808056 4207588 complement(4434938..4435513) 1 NC_008258.1 Code: K; COG: COG1309; transcriptional regulator 4435513 yjdC 4207588 yjdC Shigella flexneri 5 str. 8401 transcriptional regulator YP_691576.1 4434938 R 373384 CDS YP_691577.1 110808057 4207589 complement(4435550..4437247) 1 NC_008258.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4437247 dipZ 4207589 dipZ Shigella flexneri 5 str. 8401 thiol:disulfide interchange protein YP_691577.1 4435550 R 373384 CDS YP_691578.1 110808058 4207590 complement(4437223..4437561) 1 NC_008258.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4437561 cutA 4207590 cutA Shigella flexneri 5 str. 8401 divalent-cation tolerance protein CutA YP_691578.1 4437223 R 373384 CDS YP_691579.1 110808059 4207591 complement(4437677..4438978) 1 NC_008258.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4438978 dcuA 4207591 dcuA Shigella flexneri 5 str. 8401 anaerobic C4-dicarboxylate transporter YP_691579.1 4437677 R 373384 CDS YP_691580.1 110808060 4207592 complement(4439096..4440532) 1 NC_008258.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4440532 aspA 4207592 aspA Shigella flexneri 5 str. 8401 aspartate ammonia-lyase YP_691580.1 4439096 R 373384 CDS YP_691581.1 110808061 4207593 4440869..4441345 1 NC_008258.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 4441345 fxsA 4207593 fxsA Shigella flexneri 5 str. 8401 FxsA YP_691581.1 4440869 D 373384 CDS YP_691582.1 110808062 4207594 complement(4441361..4442617) 1 NC_008258.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein 4442617 yjeH 4207594 yjeH Shigella flexneri 5 str. 8401 hypothetical protein YP_691582.1 4441361 R 373384 CDS YP_691583.1 110808063 4207595 4442893..4443186 1 NC_008258.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4443186 groES 4207595 groES Shigella flexneri 5 str. 8401 co-chaperonin GroES YP_691583.1 4442893 D 373384 CDS YP_691584.1 110808064 4207596 4443230..4444876 1 NC_008258.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 4444876 groEL 4207596 groEL Shigella flexneri 5 str. 8401 molecular chaperone GroEL YP_691584.1 4443230 D 373384 CDS YP_691585.1 110808065 4207597 4445014..4445367 1 NC_008258.1 hypothetical protein 4445367 yjeI 4207597 yjeI Shigella flexneri 5 str. 8401 hypothetical protein YP_691585.1 4445014 D 373384 CDS YP_691586.1 110808066 4207598 complement(4445570..4446439) 1 NC_008258.1 hypothetical protein 4446439 yjeJ 4207598 yjeJ Shigella flexneri 5 str. 8401 hypothetical protein YP_691586.1 4445570 R 373384 CDS YP_691587.1 110808067 4207599 complement(4446466..4446744) 1 NC_008258.1 IS1 encoded protein 4446744 4207599 SFV_4302 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691587.1 4446466 R 373384 CDS YP_691588.1 110808068 4207600 4446819..4447322 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4447322 insB 4207600 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691588.1 4446819 D 373384 CDS YP_691589.1 110808069 4207601 complement(4447610..4448638) 1 NC_008258.1 Code: E; COG: COG1509; hypothetical protein 4448638 yjeK 4207601 yjeK Shigella flexneri 5 str. 8401 hypothetical protein YP_691589.1 4447610 R 373384 CDS YP_691590.1 110808070 4207602 4448680..4449246 1 NC_008258.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4449246 efp 4207602 efp Shigella flexneri 5 str. 8401 elongation factor P YP_691590.1 4448680 D 373384 CDS YP_691591.1 110808071 4207603 4449534..4449680 1 NC_008258.1 Code: S; COG: COG5510; entericidin B 4449680 4207603 SFV_4306 Shigella flexneri 5 str. 8401 entericidin B YP_691591.1 4449534 D 373384 CDS YP_691592.1 110808072 4209064 4449706..4450173 1 NC_008258.1 Code: P; COG: COG2076; suppresser of groEL 4450173 sugE 4209064 sugE Shigella flexneri 5 str. 8401 suppresser of groEL YP_691592.1 4449706 D 373384 CDS YP_691593.1 110808073 4209065 complement(4450170..4450703) 1 NC_008258.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4450703 blc 4209065 blc Shigella flexneri 5 str. 8401 outer membrane lipoprotein Blc YP_691593.1 4450170 R 373384 CDS YP_691594.1 110808074 4209066 complement(4450792..4451958) 1 NC_008258.1 Code: V; COG: COG1680; beta-lactamase 4451958 ampC 4209066 ampC Shigella flexneri 5 str. 8401 beta-lactamase YP_691594.1 4450792 R 373384 CDS YP_691595.1 110808075 4209067 complement(4451988..4452347) 1 NC_008258.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4452347 frdD 4209067 frdD Shigella flexneri 5 str. 8401 fumarate reductase subunit D YP_691595.1 4451988 R 373384 CDS YP_691596.1 110808076 4209068 complement(4452358..4452753) 1 NC_008258.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4452753 frdC 4209068 frdC Shigella flexneri 5 str. 8401 fumarate reductase subunit C YP_691596.1 4452358 R 373384 CDS YP_691597.1 110808077 4209069 complement(4452764..4453498) 1 NC_008258.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4453498 frdB 4209069 frdB Shigella flexneri 5 str. 8401 fumarate reductase iron-sulfur subunit YP_691597.1 4452764 R 373384 CDS YP_691598.1 110808078 4209070 complement(4453491..4455299) 1 NC_008258.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4455299 frdA 4209070 frdA Shigella flexneri 5 str. 8401 fumarate reductase flavoprotein subunit YP_691598.1 4453491 R 373384 CDS YP_691599.1 110808079 4209071 4455624..4456601 1 NC_008258.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4456601 yjeA 4209071 yjeA Shigella flexneri 5 str. 8401 lysyl-tRNA synthetase YP_691599.1 4455624 D 373384 CDS YP_691600.1 110808080 4209073 complement(4458463..4461774) 1 NC_008258.1 Code: M; COG: COG3264; hypothetical protein 4461774 yjeP 4209073 yjeP Shigella flexneri 5 str. 8401 hypothetical protein YP_691600.1 4458463 R 373384 CDS YP_691601.1 110808081 4209074 complement(4461796..4462764) 1 NC_008258.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4462764 psd 4209074 psd Shigella flexneri 5 str. 8401 phosphatidylserine decarboxylase YP_691601.1 4461796 R 373384 CDS YP_691602.1 110808082 4209075 complement(4462861..4463874) 1 NC_008258.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4463874 yjeQ 4209075 yjeQ Shigella flexneri 5 str. 8401 ribosome-associated GTPase YP_691602.1 4462861 R 373384 CDS YP_691603.2 229774924 4209076 4464008..4464553 1 NC_008258.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4464553 yjeR 4209076 yjeR Shigella flexneri 5 str. 8401 oligoribonuclease YP_691603.2 4464008 D 373384 CDS YP_691604.1 110808085 4208266 complement(4465564..4466748) 1 NC_008258.1 Code: C; COG: COG1600; hypothetical protein 4466748 yjeS 4208266 yjeS Shigella flexneri 5 str. 8401 hypothetical protein YP_691604.1 4465564 R 373384 CDS YP_691605.1 110808084 4208265 4466702..4468249 1 NC_008258.1 hypothetical protein 4468249 yjeF 4208265 yjeF Shigella flexneri 5 str. 8401 hypothetical protein YP_691605.1 4466702 D 373384 CDS YP_691606.1 110808086 4208267 4468221..4468682 1 NC_008258.1 possibly involved in cell wall synthesis; ATPase 4468682 yjeE 4208267 yjeE Shigella flexneri 5 str. 8401 ATPase YP_691606.1 4468221 D 373384 CDS YP_691607.1 110808087 4208268 4468701..4470038 1 NC_008258.1 Code: M; COG: COG0860; N-acetylmuramoyl-L-alanine amidase 4470038 amiB 4208268 amiB Shigella flexneri 5 str. 8401 N-acetylmuramoyl-L-alanine amidase YP_691607.1 4468701 D 373384 CDS YP_691608.1 110808088 4208269 4470048..4471931 1 NC_008258.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4471931 mutL 4208269 mutL Shigella flexneri 5 str. 8401 DNA mismatch repair protein YP_691608.1 4470048 D 373384 CDS YP_691609.1 110808089 4208270 4471969..4472874 1 NC_008258.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4472874 miaA 4208270 miaA Shigella flexneri 5 str. 8401 tRNA delta(2)-isopentenylpyrophosphate transferase YP_691609.1 4471969 D 373384 CDS YP_691610.1 110808090 4208271 4472960..4473268 1 NC_008258.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4473268 hfq 4208271 hfq Shigella flexneri 5 str. 8401 RNA-binding protein Hfq YP_691610.1 4472960 D 373384 CDS YP_691611.1 110808091 4208272 4473413..4474624 1 NC_008258.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4474624 hflX 4208272 hflX Shigella flexneri 5 str. 8401 GTPase HflX YP_691611.1 4473413 D 373384 CDS YP_691612.1 110808092 4208273 4474710..4475969 1 NC_008258.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4475969 hflK 4208273 hflK Shigella flexneri 5 str. 8401 FtsH protease regulator HflK YP_691612.1 4474710 D 373384 CDS YP_691613.1 110808093 4208274 4475972..4476976 1 NC_008258.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4476976 hflC 4208274 hflC Shigella flexneri 5 str. 8401 FtsH protease regulator HflC YP_691613.1 4475972 D 373384 CDS YP_691614.1 110808094 4208275 4477058..4477255 1 NC_008258.1 Code: S; COG: COG3242; hypothetical protein 4477255 yjeT 4208275 yjeT Shigella flexneri 5 str. 8401 hypothetical protein YP_691614.1 4477058 D 373384 CDS YP_691615.1 110808095 4208276 4477359..4478657 1 NC_008258.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4478657 purA 4208276 purA Shigella flexneri 5 str. 8401 adenylosuccinate synthetase YP_691615.1 4477359 D 373384 CDS YP_691616.1 110808096 4208277 4478862..4479287 1 NC_008258.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4479287 yjeB 4208277 yjeB Shigella flexneri 5 str. 8401 transcriptional repressor NsrR YP_691616.1 4478862 D 373384 CDS YP_691617.1 110808097 4208278 4479326..4481767 1 NC_008258.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4481767 vacB 4208278 vacB Shigella flexneri 5 str. 8401 exoribonuclease R YP_691617.1 4479326 D 373384 CDS YP_691618.1 110808098 4208279 4481947..4482678 1 NC_008258.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4482678 yjfH 4208279 yjfH Shigella flexneri 5 str. 8401 23S rRNA (guanosine-2'-O-)-methyltransferase YP_691618.1 4481947 D 373384 CDS YP_691619.1 110808099 4208280 complement(4482689..4482898) 1 NC_008258.1 IS1 encoded protein 4482898 4208280 SFV_4339 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691619.1 4482689 R 373384 CDS YP_691620.1 110808100 4208281 4482973..4483476 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4483476 insB 4208281 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691620.1 4482973 D 373384 CDS YP_691621.1 110808101 4208596 4483742..4484380 1 NC_008258.1 Code: S; COG: COG5463; hypothetical protein 4484380 yjfM 4208596 yjfM Shigella flexneri 5 str. 8401 hypothetical protein YP_691621.1 4483742 D 373384 CDS YP_691622.1 110808102 4208598 4485630..4487255 1 NC_008258.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4487255 aidB 4208598 aidB Shigella flexneri 5 str. 8401 isovaleryl CoA dehydrogenase YP_691622.1 4485630 D 373384 CDS YP_691623.1 110808103 4208599 complement(4487372..4487647) 1 NC_008258.1 hypothetical protein 4487647 yjfN 4208599 yjfN Shigella flexneri 5 str. 8401 hypothetical protein YP_691623.1 4487372 R 373384 CDS YP_691624.1 110808104 4208600 complement(4487796..4488224) 1 NC_008258.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A 4488224 yjfO 4208600 yjfO Shigella flexneri 5 str. 8401 biofilm stress and motility protein A YP_691624.1 4487796 R 373384 CDS YP_691625.1 110808105 4208601 4488307..4489056 1 NC_008258.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4489056 yjfP 4208601 yjfP Shigella flexneri 5 str. 8401 esterase YP_691625.1 4488307 D 373384 CDS YP_691626.1 110808106 4208602 complement(4489053..4489808) 1 NC_008258.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4489808 yjfQ 4208602 yjfQ Shigella flexneri 5 str. 8401 transcriptional repressor UlaR YP_691626.1 4489053 R 373384 CDS YP_691627.1 110808107 4208603 complement(4489916..4490971) 1 NC_008258.1 Code: R; COG: COG2220; L-ascorbate 6-phosphate lactonase 4490971 yjfR 4208603 yjfR Shigella flexneri 5 str. 8401 L-ascorbate 6-phosphate lactonase YP_691627.1 4489916 R 373384 CDS YP_691628.1 110808108 4208604 4491335..4492573 1 NC_008258.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4492573 ulaA 4208604 ulaA Shigella flexneri 5 str. 8401 PTS system ascorbate-specific transporter subunit IIC YP_691628.1 4491335 D 373384 CDS YP_691629.1 110808109 4208605 4492748..4493053 1 NC_008258.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4493053 sgaB 4208605 sgaB Shigella flexneri 5 str. 8401 PTS system L-ascorbate-specific transporter subunit IIB YP_691629.1 4492748 D 373384 CDS YP_691630.1 110808110 4208606 4493063..4493527 1 NC_008258.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4493527 ptxA 4208606 ptxA Shigella flexneri 5 str. 8401 PTS system L-ascorbate-specific transporter subunit IIA YP_691630.1 4493063 D 373384 CDS YP_691631.1 110808111 4208607 4493541..4494191 1 NC_008258.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4494191 ulaD 4208607 ulaD Shigella flexneri 5 str. 8401 3-keto-L-gulonate-6-phosphate decarboxylase YP_691631.1 4493541 D 373384 CDS YP_691632.1 110808112 4208608 4494201..4495055 1 NC_008258.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4495055 sgaU 4208608 sgaU Shigella flexneri 5 str. 8401 L-xylulose 5-phosphate 3-epimerase YP_691632.1 4494201 D 373384 CDS YP_691633.1 110808113 4208609 4495055..4495741 1 NC_008258.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4495741 sgaE 4208609 sgaE Shigella flexneri 5 str. 8401 L-ribulose-5-phosphate 4-epimerase YP_691633.1 4495055 D 373384 CDS YP_691634.1 110808114 4208610 complement(4495870..4496145) 1 NC_008258.1 hypothetical protein 4496145 yjfY 4208610 yjfY Shigella flexneri 5 str. 8401 hypothetical protein YP_691634.1 4495870 R 373384 CDS YP_691635.1 110808115 4208611 4496472..4496867 1 NC_008258.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4496867 rpsF 4208611 rpsF Shigella flexneri 5 str. 8401 30S ribosomal protein S6 YP_691635.1 4496472 D 373384 CDS YP_691636.1 110808116 4208612 4497193..4497420 1 NC_008258.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4497420 rpsR 4208612 rpsR Shigella flexneri 5 str. 8401 30S ribosomal protein S18 YP_691636.1 4497193 D 373384 CDS YP_691637.1 110808117 4208613 4497462..4497911 1 NC_008258.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4497911 rplI 4208613 rplI Shigella flexneri 5 str. 8401 50S ribosomal protein L9 YP_691637.1 4497462 D 373384 CDS YP_691638.1 110808118 4208614 4498609..4498887 1 NC_008258.1 Code: L; COG: COG2963; ISEhe3 orfA 4498887 4208614 SFV_4359 Shigella flexneri 5 str. 8401 ISEhe3 orfA YP_691638.1 4498609 D 373384 CDS YP_691639.1 110808119 4208615 4498944..4499525 1 NC_008258.1 Code: L; COG: COG2801; ISEhe3 orfB 4499525 4208615 SFV_4360 Shigella flexneri 5 str. 8401 ISEhe3 orfB YP_691639.1 4498944 D 373384 CDS YP_691640.1 110808120 4208130 complement(4499566..4500279) 1 NC_008258.1 Code: L; COG: COG2801; IS600 ORF2 4500279 4208130 SFV_4361 Shigella flexneri 5 str. 8401 IS600 ORF2 YP_691640.1 4499566 R 373384 CDS YP_691641.1 110808121 4208131 complement(4500420..4500722) 1 NC_008258.1 Code: L; COG: COG2963; IS600 ORF1 4500722 4208131 SFV_4362 Shigella flexneri 5 str. 8401 IS600 ORF1 YP_691641.1 4500420 R 373384 CDS YP_691642.1 110808122 4208132 4500787..4501107 1 NC_008258.1 Code: S; COG: COG3586; hypothetical protein 4501107 4208132 SFV_4363 Shigella flexneri 5 str. 8401 hypothetical protein YP_691642.1 4500787 D 373384 CDS YP_691643.1 110808123 4208133 complement(4501154..4501495) 1 NC_008258.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 4501495 yjiW 4208133 yjiW Shigella flexneri 5 str. 8401 endoribonuclease SymE YP_691643.1 4501154 R 373384 CDS YP_691644.1 110808124 4208134 complement(4501716..4503377) 1 NC_008258.1 Code: V; COG: COG0732; hypothetical protein 4503377 4208134 SFV_4365 Shigella flexneri 5 str. 8401 hypothetical protein YP_691644.1 4501716 R 373384 CDS YP_691645.1 110808125 4208135 complement(4503377..4504867) 1 NC_008258.1 Code: V; COG: COG0286; restriction modification enzyme M subunit 4504867 4208135 SFV_4366 Shigella flexneri 5 str. 8401 restriction modification enzyme M subunit YP_691645.1 4503377 R 373384 CDS YP_691646.1 110808126 4208136 complement(4504913..4507345) 1 NC_008258.1 Code: V; COG: COG4096; restriction modification enzyme R subunit 4507345 4208136 SFV_4367 Shigella flexneri 5 str. 8401 restriction modification enzyme R subunit YP_691646.1 4504913 R 373384 CDS YP_691647.1 110808127 4208137 complement(4507480..4507761) 1 NC_008258.1 IS1 encoded protein 4507761 4208137 SFV_4368 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691647.1 4507480 R 373384 CDS YP_691648.1 110808128 4208138 4507836..4508339 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4508339 insB 4208138 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691648.1 4507836 D 373384 CDS YP_691649.1 110808129 4208139 4508478..4509116 1 NC_008258.1 hypothetical protein 4509116 4208139 SFV_4370 Shigella flexneri 5 str. 8401 hypothetical protein YP_691649.1 4508478 D 373384 CDS YP_691650.1 110808130 4208140 complement(4509185..4510141) 1 NC_008258.1 Code: R; COG: COG0523; GTP-binding protein YjiA 4510141 yjiA 4208140 yjiA Shigella flexneri 5 str. 8401 GTP-binding protein YjiA YP_691650.1 4509185 R 373384 CDS YP_691651.1 110808131 4208141 complement(4510152..4510355) 1 NC_008258.1 Code: S; COG: COG2879; hypothetical protein 4510355 yjiX 4208141 yjiX Shigella flexneri 5 str. 8401 hypothetical protein YP_691651.1 4510152 R 373384 CDS YP_691652.1 110808132 4208142 complement(4510405..4512570) 1 NC_008258.1 Code: T; COG: COG1966; carbon starvation protein 4512570 yjiY 4208142 yjiY Shigella flexneri 5 str. 8401 carbon starvation protein YP_691652.1 4510405 R 373384 CDS YP_691653.1 110808133 4208143 complement(4512948..4513460) 1 NC_008258.1 Code: R; COG: COG1853; component C of the 4HPA-hydroxylase 4513460 hpaC 4208143 hpaC Shigella flexneri 5 str. 8401 component C of the 4HPA-hydroxylase YP_691653.1 4512948 R 373384 CDS YP_691654.1 110808134 4208145 complement(4515289..4516119) 1 NC_008258.1 Code: R; COG: COG1234; hypothetical protein 4516119 4208145 SFV_4376 Shigella flexneri 5 str. 8401 hypothetical protein YP_691654.1 4515289 R 373384 CDS YP_691655.1 110808135 4208146 complement(4516227..4517117) 1 NC_008258.1 Code: K; COG: COG2207; 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein 4517117 hpaA 4208146 hpaA Shigella flexneri 5 str. 8401 4-hydroxyphenylacetate 3-monooxygenase operon regulatory protein YP_691655.1 4516227 R 373384 CDS YP_691656.1 110808136 4208147 complement(4517127..4518482) 1 NC_008258.1 Code: GEPR; COG: COG0477; 4-hydroxyphenylacetate permease 4518482 hpaX 4208147 hpaX Shigella flexneri 5 str. 8401 4-hydroxyphenylacetate permease YP_691656.1 4517127 R 373384 CDS YP_691657.1 110808137 4208148 complement(4518504..4519079) 1 NC_008258.1 Code: G; COG: COG3836; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase 4519079 hpaI 4208148 hpaI Shigella flexneri 5 str. 8401 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase YP_691657.1 4518504 R 373384 CDS YP_691658.1 110808138 4206724 complement(4519314..4520117) 1 NC_008258.1 Code: Q; COG: COG3971; 2-oxo-hept-3-ene-1, 7-dioate hydratase 4520117 hpaH 4206724 hpaH Shigella flexneri 5 str. 8401 2-oxo-hept-3-ene-1, 7-dioate hydratase YP_691658.1 4519314 R 373384 CDS YP_691659.1 110808139 4206725 complement(4520185..4520565) 1 NC_008258.1 Code: E; COG: COG3232; 5-carboxymethyl-2-hydroxymuconate delta-isomerase 4520565 hpaF 4206725 hpaF Shigella flexneri 5 str. 8401 5-carboxymethyl-2-hydroxymuconate delta-isomerase YP_691659.1 4520185 R 373384 CDS YP_691660.1 110808140 4206726 complement(4520575..4521429) 1 NC_008258.1 Code: S; COG: COG3384; homoprotocatechuate dyoxygenase 4521429 hpaD 4206726 hpaD Shigella flexneri 5 str. 8401 homoprotocatechuate dyoxygenase YP_691660.1 4520575 R 373384 CDS YP_691661.1 110808141 4206727 complement(4521431..4522897) 1 NC_008258.1 Code: C; COG: COG1012; 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase 4522897 hpaE 4206727 hpaE Shigella flexneri 5 str. 8401 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase YP_691661.1 4521431 R 373384 CDS YP_691662.1 110808142 4206728 complement(4522894..4524183) 1 NC_008258.1 Code: Q; COG: COG0179; 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxylase/isomerase 4524183 hpaG 4206728 hpaG Shigella flexneri 5 str. 8401 5-oxo-1,2,5-tricarboxilic-3-penten acid decarboxylase/isomerase YP_691662.1 4522894 R 373384 CDS YP_691663.1 110808143 4206729 4524455..4524901 1 NC_008258.1 Code: K; COG: COG1846; regulator of the 4HPA-hydroxylase operon 4524901 hpcR 4206729 hpcR Shigella flexneri 5 str. 8401 regulator of the 4HPA-hydroxylase operon YP_691663.1 4524455 D 373384 CDS YP_691664.1 110808144 4206730 4525020..4526684 1 NC_008258.1 Code: NT; COG: COG0840; methyl-accepting chemotaxis protein I, serine sensor receptor 4526684 tsr 4206730 tsr Shigella flexneri 5 str. 8401 methyl-accepting chemotaxis protein I, serine sensor receptor YP_691664.1 4525020 D 373384 CDS YP_691665.1 110808145 4206731 complement(4526733..4528094) 1 NC_008258.1 Code: GEPR; COG: COG0477; transport protein 4528094 yjiZ 4206731 yjiZ Shigella flexneri 5 str. 8401 transport protein YP_691665.1 4526733 R 373384 CDS YP_691666.1 110808146 4206732 complement(4528528..4529223) 1 NC_008258.1 Code: K; COG: COG1802; hypothetical protein 4529223 yjjM 4206732 yjjM Shigella flexneri 5 str. 8401 hypothetical protein YP_691666.1 4528528 R 373384 CDS YP_691667.1 110808147 4206733 4529617..4530384 1 NC_008258.1 Code: ER; COG: COG1063; oxidoreductase 4530384 yjjN 4206733 yjjN Shigella flexneri 5 str. 8401 oxidoreductase YP_691667.1 4529617 D 373384 CDS YP_691668.2 162139313 4206734 complement(4530522..4532735) 1 NC_008258.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 4532735 mdoB 4206734 mdoB Shigella flexneri 5 str. 8401 phosphoglycerol transferase I YP_691668.2 4530522 R 373384 CDS YP_691669.1 110808149 4206735 complement(4533066..4533563) 1 NC_008258.1 hypothetical protein 4533563 yjjA 4206735 yjjA Shigella flexneri 5 str. 8401 hypothetical protein YP_691669.1 4533066 R 373384 CDS YP_691670.1 110808150 4206736 complement(4533609..4534346) 1 NC_008258.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 4534346 dnaC 4206736 dnaC Shigella flexneri 5 str. 8401 DNA replication protein DnaC YP_691670.1 4533609 R 373384 CDS YP_691671.1 110808151 4206737 complement(4534349..4534900) 1 NC_008258.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 4534900 dnaT 4206737 dnaT Shigella flexneri 5 str. 8401 primosomal protein DnaI YP_691671.1 4534349 R 373384 CDS YP_691672.1 110808152 4206738 complement(4534995..4535468) 1 NC_008258.1 Code: S; COG: COG3610; hypothetical protein 4535468 yjjB 4206738 yjjB Shigella flexneri 5 str. 8401 hypothetical protein YP_691672.1 4534995 R 373384 CDS YP_691673.1 110808153 4206739 complement(4535459..4536229) 1 NC_008258.1 Code: S; COG: COG2966; structural protein 4536229 yjjP 4206739 yjjP Shigella flexneri 5 str. 8401 structural protein YP_691673.1 4535459 R 373384 CDS YP_691674.1 110808154 4206740 complement(4536754..4536972) 1 NC_008258.1 IS1 encoded protein 4536972 4206740 SFV_4396 Shigella flexneri 5 str. 8401 IS1 encoded protein YP_691674.1 4536754 R 373384 CDS YP_691675.1 110808155 4206741 4537047..4537550 1 NC_008258.1 Code: L; COG: COG1662; IS1 ORF2 4537550 insB 4206741 insB Shigella flexneri 5 str. 8401 IS1 ORF2 YP_691675.1 4537047 D 373384 CDS YP_691676.1 110808156 4206742 4537552..4538136 1 NC_008258.1 Code: TK; COG: COG2197; regulator 4538136 yjjQ 4206742 yjjQ Shigella flexneri 5 str. 8401 regulator YP_691676.1 4537552 D 373384 CDS YP_691677.1 110808157 4206743 4538094..4538771 1 NC_008258.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 4538771 bglJ 4206743 bglJ Shigella flexneri 5 str. 8401 DNA-binding transcriptional activator BglJ YP_691677.1 4538094 D 373384 CDS YP_691678.1 110808158 4208765 complement(4538809..4539597) 1 NC_008258.1 Code: R; COG: COG4114; ferric hydroximate transport ferric iron reductase 4539597 fhuF 4208765 fhuF Shigella flexneri 5 str. 8401 ferric hydroximate transport ferric iron reductase YP_691678.1 4538809 R 373384 CDS YP_691679.1 110808159 4208766 4539627..4539974 1 NC_008258.1 inner membrane protein 4539974 4208766 SFV_4401 Shigella flexneri 5 str. 8401 inner membrane protein YP_691679.1 4539627 D 373384 CDS YP_691680.1 110808160 4208770 complement(4540612..4541643) 1 NC_008258.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 4541643 rsmC 4208770 rsmC Shigella flexneri 5 str. 8401 16S ribosomal RNA m2G1207 methyltransferase YP_691680.1 4540612 R 373384 CDS YP_691681.1 110808161 4208771 4541746..4542159 1 NC_008258.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 4542159 holD 4208771 holD Shigella flexneri 5 str. 8401 DNA polymerase III subunit psi YP_691681.1 4541746 D 373384 CDS YP_691682.1 110808162 4208772 4542128..4542574 1 NC_008258.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 4542574 rimI 4208772 rimI Shigella flexneri 5 str. 8401 ribosomal-protein-alanine N-acetyltransferase YP_691682.1 4542128 D 373384 CDS YP_691683.1 110808163 4208773 4542589..4543266 1 NC_008258.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 4543266 yjjG 4208773 yjjG Shigella flexneri 5 str. 8401 nucleotidase YP_691683.1 4542589 D 373384 CDS YP_691684.1 110808164 4208774 4543357..4544946 1 NC_008258.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 4544946 prfC 4208774 prfC Shigella flexneri 5 str. 8401 peptide chain release factor 3 YP_691684.1 4543357 D 373384 CDS YP_691685.1 110808165 4208775 4545339..4545944 1 NC_008258.1 Code: R; COG: COG2823; periplasmic protein 4545944 osmY 4208775 osmY Shigella flexneri 5 str. 8401 periplasmic protein YP_691685.1 4545339 D 373384 CDS YP_691686.1 110808166 4208776 4546354..4547427 1 NC_008258.1 Code: R; COG: COG4667; hypothetical protein 4547427 yjjU 4208776 yjjU Shigella flexneri 5 str. 8401 hypothetical protein YP_691686.1 4546354 D 373384 CDS YP_691687.1 110808167 4208777 4547424..4548206 1 NC_008258.1 Code: L; COG: COG0084; deoxyribonuclease YjjV 4548206 yjjV 4208777 yjjV Shigella flexneri 5 str. 8401 deoxyribonuclease YjjV YP_691687.1 4547424 D 373384 CDS YP_691688.1 110808168 4208778 complement(4548420..4549283) 1 NC_008258.1 Code: O; COG: COG1180; activating enzyme 4549283 yjjW 4208778 yjjW Shigella flexneri 5 str. 8401 activating enzyme YP_691688.1 4548420 R 373384 CDS YP_691689.1 110808169 4208779 complement(4549255..4550796) 1 NC_008258.1 hypothetical protein 4550796 yjjI 4208779 yjjI Shigella flexneri 5 str. 8401 hypothetical protein YP_691689.1 4549255 R 373384 CDS YP_691690.1 110808170 4208780 4551054..4551833 1 NC_008258.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 4551833 deoC 4208780 deoC Shigella flexneri 5 str. 8401 deoxyribose-phosphate aldolase YP_691690.1 4551054 D 373384 CDS YP_691691.1 110808171 4208244 4551960..4553282 1 NC_008258.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4553282 deoA 4208244 deoA Shigella flexneri 5 str. 8401 thymidine phosphorylase YP_691691.1 4551960 D 373384 CDS YP_691692.1 110808172 4208245 4553334..4554557 1 NC_008258.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 4554557 deoB 4208245 deoB Shigella flexneri 5 str. 8401 phosphopentomutase YP_691692.1 4553334 D 373384 CDS YP_691693.1 110808173 4208246 4554614..4555333 1 NC_008258.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 4555333 deoD 4208246 deoD Shigella flexneri 5 str. 8401 purine nucleoside phosphorylase YP_691693.1 4554614 D 373384 CDS YP_691694.1 110808174 4208247 complement(4555494..4555757) 1 NC_008258.1 Code: K; COG: COG1396; hypothetical protein 4555757 4208247 SFV_4419 Shigella flexneri 5 str. 8401 hypothetical protein YP_691694.1 4555494 R 373384 CDS YP_691695.1 110808175 4208249 complement(4556832..4557476) 1 NC_008258.1 Code: R; COG: COG3726; hypothetical protein 4557476 smp 4208249 smp Shigella flexneri 5 str. 8401 hypothetical protein YP_691695.1 4556832 R 373384 CDS YP_691696.1 110808176 4208250 4557582..4558550 1 NC_008258.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 4558550 serB 4208250 serB Shigella flexneri 5 str. 8401 phosphoserine phosphatase YP_691696.1 4557582 D 373384 CDS YP_691697.1 110808177 4208251 4558599..4559981 1 NC_008258.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4559981 sms 4208251 sms Shigella flexneri 5 str. 8401 DNA repair protein RadA YP_691697.1 4558599 D 373384 CDS YP_691698.1 110808178 4208252 4560002..4561234 1 NC_008258.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 4561234 nadR 4208252 nadR Shigella flexneri 5 str. 8401 nicotinamide-nucleotide adenylyltransferase YP_691698.1 4560002 D 373384 CDS YP_691699.1 110808179 4208253 complement(4561542..4563188) 1 NC_008258.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 4563188 yjjK 4208253 yjjK Shigella flexneri 5 str. 8401 ABC transporter ATP-binding protein YP_691699.1 4561542 R 373384 CDS YP_691700.1 110808180 4208254 4563420..4565357 1 NC_008258.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 4565357 slt 4208254 slt Shigella flexneri 5 str. 8401 lytic murein transglycosylase YP_691700.1 4563420 D 373384 CDS YP_691701.1 110808181 4208255 4565447..4565773 1 NC_008258.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 4565773 trpR 4208255 trpR Shigella flexneri 5 str. 8401 Trp operon repressor YP_691701.1 4565447 D 373384 CDS YP_691702.1 110808182 4208256 complement(4565905..4566387) 1 NC_008258.1 Code: S; COG: COG1986; hypothetical protein 4566387 yjjX 4208256 yjjX Shigella flexneri 5 str. 8401 hypothetical protein YP_691702.1 4565905 R 373384 CDS YP_691703.1 110808183 4208257 4566430..4567077 1 NC_008258.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 4567077 gpmB 4208257 gpmB Shigella flexneri 5 str. 8401 phosphoglycerate mutase YP_691703.1 4566430 D 373384 CDS YP_691704.1 110808184 4208258 complement(4567074..4567943) 1 NC_008258.1 Code: K; COG: COG2207; right origin-binding protein 4567943 rob 4208258 rob Shigella flexneri 5 str. 8401 right origin-binding protein YP_691704.1 4567074 R 373384 CDS YP_691705.1 110808185 4208259 4568154..4568627 1 NC_008258.1 Code: S; COG: COG3045; hypothetical protein 4568627 creA 4208259 creA Shigella flexneri 5 str. 8401 hypothetical protein YP_691705.1 4568154 D 373384 CDS YP_691706.1 110808186 4208260 4568640..4569329 1 NC_008258.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 4569329 creB 4208260 creB Shigella flexneri 5 str. 8401 DNA-binding response regulator CreB YP_691706.1 4568640 D 373384 CDS YP_691707.1 110808187 4208261 4569329..4570753 1 NC_008258.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 4570753 creC 4208261 creC Shigella flexneri 5 str. 8401 sensory histidine kinase CreC YP_691707.1 4569329 D 373384 CDS YP_691708.1 110808188 4208262 4570811..4572163 1 NC_008258.1 Code: V; COG: COG4452; hypothetical protein 4572163 creD 4208262 creD Shigella flexneri 5 str. 8401 hypothetical protein YP_691708.1 4570811 D 373384 CDS YP_691709.1 110808189 4208263 complement(4572222..4572938) 1 NC_008258.1 Code: TK; COG: COG0745; two-component response regulator 4572938 arcA 4208263 arcA Shigella flexneri 5 str. 8401 two-component response regulator YP_691709.1 4572222 R 373384 CDS YP_691710.1 110808190 4208817 4573574..4574260 1 NC_008258.1 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 4574260 lasT 4208817 lasT Shigella flexneri 5 str. 8401 RNA methyltransferase YP_691710.1 4573574 D 373384 CDS