-- dump date   	20140620_065414
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_687595.1	multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_687596.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_687597.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_687599.1	Code: S; COG: COG3022
YP_687600.2	Code: G; COG: COG0176
YP_687601.1	forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_687602.1	Code: S; COG: COG1584
YP_687603.1	Code: S; COG: COG4735
YP_687605.1	DNA biosynthesis; heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_687606.1	heat shock protein; chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_687607.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_687608.1	Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC
YP_687609.1	Code: L; COG: COG1662
YP_687611.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_687612.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_687613.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme
YP_687614.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_687615.1	a rotamase; Code: O; COG: COG1047
YP_687616.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_687617.1	catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides
YP_687618.2	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_687619.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_687620.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_687621.1	regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons
YP_687622.1	involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities
YP_687623.1	catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
YP_687624.1	Code: IQ; COG: COG0318
YP_687625.1	catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine
YP_687626.1	catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA
YP_687627.1	catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism
YP_687628.1	required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase
YP_687629.1	electron transport; FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction
YP_687630.1	Code: C; COG: COG2440
YP_687631.1	Code: GEPR; COG: COG0477
YP_687632.1	Required for full activity of KefC, a potassium-proton antiporter
YP_687633.1	transport system that facilitates potassium-efflux
YP_687634.1	catalyzes the reduction of dihydrofolate to tetrahydrofolate
YP_687635.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_687636.1	protein associated with Co2+ and Mg2+ efflux
YP_687637.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_687638.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_687639.1	Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB
YP_687640.1	determines N-hexane tolerance and is involved in outer membrane permeability
YP_687641.1	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_687642.1	catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs
YP_687643.1	transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
YP_687644.1	Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C
YP_687645.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_687646.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_687647.1	catalyzes the phosphorylation of ribulose to ribulose 5-phosphate
YP_687648.1	positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose
YP_687649.1	Code: S; COG: COG0586
YP_687650.1	with TbpA and ThiP is part of the thiamine and TPP transport system
YP_687651.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_687652.1	part of the thiamine and TPP transport system tbpA-thiPQ
YP_687653.1	activates sgrS under glucose-phosphate stress conditions
YP_687654.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_687655.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_687656.2	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_687657.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_687658.1	activator for leuABCD operon; member of LysR family of transcriptional activators
YP_687659.2	catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive
YP_687660.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_687662.1	binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism
YP_687664.1	Code: L; COG: COG1662
YP_687665.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_687666.1	Code: M; COG: COG0275
YP_687667.1	membrane bound cell division protein at septum containing leucine zipper motif
YP_687668.1	Code: M; COG: COG0768
YP_687669.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_687670.1	Code: M; COG: COG0770
YP_687671.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_687672.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_687673.1	integral membrane protein involved in stabilizing FstZ ring during cell division
YP_687674.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_687675.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_687676.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_687677.1	involved in septum formation
YP_687678.1	ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane
YP_687679.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_687680.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_687681.1	secM translational pause allows for the initiation of secA translation
YP_687682.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_687683.1	Code: LR; COG: COG0494
YP_687684.1	Code: S; COG: COG3024
YP_687685.1	Code: S; COG: COG4582
YP_687686.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_687687.1	catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate
YP_687688.1	Code: NU; COG: COG1459
YP_687689.1	Code: NU; COG: COG4969
YP_687690.1	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_687691.1	Code: V; COG: COG3023
YP_687692.1	involved in regulation of beta-lactamase; signaling protein
YP_687693.1	Code: E; COG: COG1113
YP_687694.1	activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex
YP_687695.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_687696.1	E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains
YP_687697.1	E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_687699.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_687700.1	Code: S; COG: COG3112
YP_687701.1	S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_687702.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_687704.1	laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification
YP_687705.1	Code: G; COG: COG4993
YP_687706.1	Code: F; COG: COG0634
YP_687707.1	catalyzes the interconversion of bicarbonate and carbon dioxide
YP_687708.1	Code: V; COG: COG1131
YP_687709.1	Code: V; COG: COG0842
YP_687710.1	Code: G; COG: COG0726
YP_687711.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_687712.1	Code: S; COG: COG5464
YP_687713.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_687714.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_687716.1	Code: L; COG: COG1662
YP_687717.1	catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP
YP_687718.1	Polymerase that creates the 3' poly(A) tail found in some mRNA's
YP_687719.2	this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu
YP_687720.1	Code: T; COG: COG1734
YP_687721.1	Regulatory factor involved in maltose metabolism
YP_687722.1	Code: J; COG: COG1514
YP_687723.1	similar in sequence to the ATP-dependent RNA helicase HrpA
YP_687724.1	bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell
YP_687725.1	involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein
YP_687726.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter
YP_687727.1	Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores
YP_687728.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome
YP_687729.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_687730.1	Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation
YP_687731.1	essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors
YP_687732.1	Code: S; COG: COG2860
YP_687733.1	solute binding component of the vitamin B12 transport system BtuCDF
YP_687734.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_687735.1	forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate
YP_687736.1	heat shock protein HtrA; protease Do; required at high temperature; degrades damaged proteins
YP_687738.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_687739.1	catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein
YP_687740.2	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_687741.2	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_687742.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_687743.1	Catalyzes the phosphorylation of UMP to UDP
YP_687744.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_687745.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_687746.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_687747.1	catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate
YP_687748.1	catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response
YP_687749.1	part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins
YP_687750.1	Code: M; COG: COG2825
YP_687751.1	adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_687752.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_687753.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_687754.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_687755.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_687756.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_687757.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_687758.1	Code: E; COG: COG1982
YP_687759.1	Code: E; COG: COG0346
YP_687760.1	Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination
YP_687762.1	Code: S; COG: COG4681
YP_687763.1	Code: J; COG: COG1186
YP_687764.1	Code: MP; COG: COG3015
YP_687766.2	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_687767.1	Code: S; COG: COG1720
YP_687769.1	Code: P; COG: COG1464
YP_687770.1	part of the MetNIQ methionine uptake system
YP_687771.1	part of the metNIQ transport system for methionine
YP_687772.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_687773.1	catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid
YP_687774.1	Code: L; COG: COG3385
YP_687775.1	Code: K; COG: COG0583
YP_687776.1	Code: S; COG: COG3021
YP_687777.1	Code: QR; COG: COG0500
YP_687778.1	catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall
YP_687779.1	catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione
YP_687780.1	Code: QR; COG: COG0500
YP_687781.1	degrades RNA of DNA-RNA hybrids, participates in DNA replication; An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_687782.1	3'-5' exonuclease of DNA polymerase III
YP_687783.1	Code: S; COG: COG3515
YP_687786.1	Code: S; COG: COG3518
YP_687787.1	Code: R; COG: COG4455
YP_687789.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_687790.1	Code: L; COG: COG2801
YP_687793.1	Code: R; COG: COG3772
YP_687798.1	Code: L; COG: COG2963
YP_687800.1	Code: R; COG: COG5565
YP_687812.1	Code: L; COG: COG2963
YP_687813.1	Code: L; COG: COG2801
YP_687815.1	Code: L; COG: COG2963
YP_687819.1	Code: R; COG: COG3740
YP_687820.1	Code: R; COG: COG4653
YP_687826.1	Code: R; COG: COG4386
YP_687831.1	Code: R; COG: COG4379
YP_687833.1	Code: S; COG: COG4381
YP_687834.1	Code: S; COG: COG3299
YP_687835.1	Code: S; COG: COG3778
YP_687838.1	Code: M; COG: COG0463
YP_687840.1	Code: L; COG: COG0582
YP_687849.1	Code: L; COG: COG1662
YP_687851.1	Code: KT; COG: COG1974
YP_687852.1	Code: L; COG: COG3385
YP_687854.1	Code: L; COG: COG0305
YP_687857.1	Code: L; COG: COG4570
YP_687860.1	Code: G; COG: COG4678
YP_687863.1	Code: L; COG: COG2963
YP_687864.1	Code: L; COG: COG2801
YP_687865.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_687866.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_687867.1	Code: L; COG: COG1662
YP_687869.1	Code: M; COG: COG3203
YP_687870.1	involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS
YP_687871.1	forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation
YP_687872.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_687873.1	Code: E; COG: COG2195
YP_687874.1	mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY
YP_687875.1	Code: KR; COG: COG0454
YP_687876.1	YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function
YP_687877.1	Code: D; COG: COG2161
YP_687878.1	tRNA synthetase; involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_687879.1	Code: N; COG: COG1360
YP_687880.1	Code: NU; COG: COG1298
YP_687881.1	Code: L; COG: COG1943
YP_687882.1	Code: M; COG: COG0791
YP_687883.1	Code: S; COG: COG3034
YP_687884.1	Code: R; COG: COG0121
YP_687885.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_687886.1	functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA
YP_687887.1	inactivates vertebrate C-type lysozyme
YP_687888.1	Code: R; COG: COG0388
YP_687892.1	Code: S; COG: COG5435
YP_687893.1	Code: S; COG: COG3501
YP_687894.1	Code: L; COG: COG1662
YP_687896.1	Code: C; COG: COG0247
YP_687897.1	Code: C; COG: COG1139
YP_687898.1	Code: S; COG: COG1556
YP_687901.1	a flavoprotein; catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine
YP_687902.1	catalyzes the formation of betaine from betaine aldehyde
YP_687903.1	HTH-type; bet1; Repressor involved in choline regulation of the bet genes
YP_687904.1	proton-motive-force-driven choline transporter
YP_687906.1	Code: L; COG: COG1662
YP_687907.1	Code: L; COG: COG2801
YP_687908.1	Code: P; COG: COG4521
YP_687909.1	Part of the ABC transporter complex tauABC involved in taurine import
YP_687910.1	Code: P; COG: COG0600
YP_687911.1	catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers
YP_687912.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_687913.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_687914.1	Code: L; COG: COG2801
YP_687915.1	Code: L; COG: COG2801
YP_687917.1	this protein has no known enzymatic function
YP_687918.1	in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope
YP_687922.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_687924.1	Code: P; COG: COG1785
YP_687926.1	Code: L; COG: COG2801
YP_687927.1	Code: L; COG: COG2963
YP_687928.1	catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis
YP_687929.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_687930.1	Code: S; COG: COG1671
YP_687931.1	type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_687934.1	Code: S; COG: COG3123
YP_687937.2	Required for efficient pilin antigenic variation
YP_687938.1	catalyzes phosphorylation of fructose; cytosolic enzyme
YP_687939.1	member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers
YP_687940.1	with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity
YP_687941.1	with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity
YP_687942.1	two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB
YP_687943.1	membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB
YP_687944.1	Code: E; COG: COG1114
YP_687945.1	cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation
YP_687946.1	Code: G; COG: COG0366
YP_687947.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_687948.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_687949.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_687950.2	protein secretion; membrane protein, part of the channel; part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_687951.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_687953.1	nucleoside channel; receptor of phage T6 and colicin K; Code: M; COG: COG3248
YP_687955.1	Code: K; COG: COG1327
YP_687956.1	riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil
YP_687957.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_687958.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_687959.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_687960.1	hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate
YP_687961.1	Code: C; COG: COG0667
YP_687962.2	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_687963.1	Code: H; COG: COG0142
YP_687964.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_687965.1	Required for the synthesis of the thiazole moiety
YP_687966.1	Code: R; COG: COG0693
YP_687967.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_687968.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_687970.1	Code: S; COG: COG2849
YP_687971.1	Code: GEPR; COG: COG0477
YP_687972.1	Code: R; COG: COG0790
YP_687974.1	Code: KR; COG: COG0454
YP_687975.1	Code: S; COG: COG4453
YP_687976.1	Code: C; COG: COG3125
YP_687977.1	Code: C; COG: COG1845
YP_687980.1	Code: L; COG: COG3436
YP_687982.1	in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein
YP_687983.1	Code: M; COG: COG3056
YP_687984.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_687985.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_687986.1	binds and unfolds substrates as part of the ClpXP protease
YP_687987.1	heat shock K-protein; Code: O; COG: COG0466
YP_687988.1	histone-like DNA-binding protein
YP_687989.1	Code: O; COG: COG0760
YP_687990.1	Code: L; COG: COG1555
YP_687991.1	Code: R; COG: COG0824
YP_687992.1	YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His
YP_687993.1	Code: R; COG: COG4533
YP_687994.1	Code: R; COG: COG0561
YP_687995.1	Code: K; COG: COG1522
YP_687996.1	Code: V; COG: COG1132
YP_687997.1	Code: V; COG: COG1132
YP_687998.1	Code: E; COG: COG0347
YP_687999.1	Code: P; COG: COG0004
YP_688000.1	Code: I; COG: COG1946
YP_688001.1	Code: S; COG: COG3126
YP_688002.1	Code: L; COG: COG3385
YP_688003.1	Code: L; COG: COG3695
YP_688004.1	Code: S; COG: COG5507
YP_688005.1	Code: T; COG: COG4943
YP_688007.1	Code: R; COG: COG0110
YP_688009.1	Code: V; COG: COG0841
YP_688010.1	Code: M; COG: COG0845
YP_688011.1	regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine
YP_688012.1	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_688014.1	PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks
YP_688015.1	Code: S; COG: COG2832
YP_688016.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_688017.1	DNA elongation factor III; catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_688018.1	Code: S; COG: COG0718
YP_688019.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_688020.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_688021.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_688022.1	Code: I; COG: COG0657
YP_688024.1	YbaL; member of the CPA-2 family of antiporters; uncharacterized protein
YP_688025.1	Code: GEPR; COG: COG0477
YP_688026.1	Code: S; COG: COG2606
YP_688027.1	Code: S; COG: COG3735
YP_688028.1	Code: R; COG: COG3093
YP_688029.1	Code: P; COG: COG2217
YP_688030.1	catalyzes the formation of glutamate from glutamine
YP_688031.1	Code: E; COG: COG0531
YP_688032.1	activator of copper-responsive regulon genes
YP_688033.1	Code: OU; COG: COG1585
YP_688034.1	Code: O; COG: COG0330
YP_688035.1	Code: R; COG: COG4619
YP_688036.1	Code: R; COG: COG0390
YP_688037.1	Code: O; COG: COG3118
YP_688038.1	Code: IQR; COG: COG1028
YP_688039.1	Code: Q; COG: COG4181
YP_688040.1	Code: Q; COG: COG3127
YP_688041.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_688042.1	activator of the allDC-ylbA operon involved in allantoin utilization
YP_688043.1	catalyzes the formation of glyoxylate from (S)-ureidoglycolate
YP_688044.1	regulates operons involved in the utilization of allantoin
YP_688045.1	catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate
YP_688046.1	Code: L; COG: COG1662
YP_688047.1	Code: R; COG: COG3257
YP_688048.1	allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide
YP_688050.1	Code: E; COG: COG0549
YP_688051.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_688052.1	Code: F; COG: COG0041
YP_688053.1	catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine
YP_688054.1	Code: O; COG: COG0652
YP_688055.2	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_688056.1	Code: R; COG: COG1988
YP_688057.1	Code: S; COG: COG2501
YP_688058.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_688059.1	Code: NU; COG: COG3539
YP_688060.1	Code: L; COG: COG1662
YP_688062.1	Code: NU; COG: COG3539
YP_688063.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_688064.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688065.1	activates the production of the major fimbrae protein FimA
YP_688066.1	thermoregulation of porin biosynthesis; Code: K; COG: COG2207
YP_688069.1	Code: T; COG: COG0642
YP_688070.1	response regulator in two-component regulatory system with CusS; regulates the copper efflux system
YP_688071.1	Code: S; COG: COG5569
YP_688072.1	Code: L; COG: COG2801
YP_688073.1	Code: L; COG: COG2963
YP_688075.1	Code: L; COG: COG2801
YP_688076.1	Code: L; COG: COG2963
YP_688077.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_688078.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688079.1	Code: P; COG: COG3696
YP_688080.1	Code: E; COG: COG1113
YP_688081.1	Code: M; COG: COG0668
YP_688082.1	catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive
YP_688083.1	Code: S; COG: COG2315
YP_688085.1	ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity
YP_688086.1	Code: L; COG: COG2963
YP_688087.1	Code: L; COG: COG2801
YP_688088.1	Code: L; COG: COG2801
YP_688089.1	Code: L; COG: COG2963
YP_688090.1	Code: L; COG: COG2963
YP_688091.1	Code: L; COG: COG2801
YP_688092.1	Code: Q; COG: COG2977
YP_688093.1	Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_688094.1	Code: P; COG: COG2382
YP_688095.1	Code: S; COG: COG3251
YP_688096.1	with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin
YP_688098.1	Code: L; COG: COG1662
YP_688099.1	with FepBDE is involved in the transport of ferric enterobactin
YP_688100.1	with FepBCD is involved in the transport of ferric enterobactin
YP_688101.1	with FepBCG is involved in the transport of ferric enterobactin
YP_688102.1	protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters
YP_688103.1	with FepCDG is involved in the transport of ferric enterobactin
YP_688104.1	bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate
YP_688105.1	Code: Q; COG: COG1535
YP_688106.1	catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin
YP_688107.1	Code: Q; COG: COG2050
YP_688108.1	Code: T; COG: COG1966
YP_688109.1	Code: S; COG: COG2879
YP_688110.1	member of the iron-containing alcohol dehydrogenase; unknown function
YP_688111.1	catalyzes the transfer of an amino moiety
YP_688112.1	Code: K; COG: COG1475
YP_688113.1	Code: L; COG: COG2801
YP_688114.1	Code: L; COG: COG2963
YP_688117.1	Code: L; COG: COG2963
YP_688118.1	Code: L; COG: COG2801
YP_688119.1	Code: K; COG: COG0583
YP_688120.1	Involved in disulfide bond formation
YP_688121.1	detoxification of hydroperoxides; with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate
YP_688122.1	Code: O; COG: COG3634
YP_688123.1	Code: T; COG: COG0589
YP_688124.1	Code: ER; COG: COG1063
YP_688125.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_688126.1	cleaves phosphodiester bond between any two nucleotides; Code: J; COG: COG3719
YP_688127.1	Code: P; COG: COG0471
YP_688128.1	catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA
YP_688129.1	2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate
YP_688130.1	Code: C; COG: COG3051
YP_688131.1	Code: G; COG: COG2301
YP_688132.1	acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate
YP_688133.1	Code: L; COG: COG1662
YP_688134.1	Code: L; COG: COG0582
YP_688135.1	YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily
YP_688136.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_688137.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_688138.1	with ModCB is involved in the high-affinity transport of molybdate
YP_688140.1	represses the modABCD operon and activates the moaABCD and napFDAGHBC operons
YP_688141.1	contains 2 ATP-binding cassettes; involved in the transport of molybdenum
YP_688142.1	Code: M; COG: COG1087
YP_688143.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_688144.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_688145.1	catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose
YP_688146.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_688147.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_688149.1	involved in zinc efflux across the cytoplasmic membrane
YP_688150.1	Code: H; COG: COG3201
YP_688151.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_688152.1	periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity
YP_688153.1	Code: M; COG: COG2885
YP_688154.1	forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_688155.1	inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins
YP_688156.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_688157.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_688158.1	catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components
YP_688159.1	Code: S; COG: COG3790
YP_688160.1	Code: C; COG: COG1294
YP_688161.1	Code: C; COG: COG1271
YP_688162.1	Code: G; COG: COG0383
YP_688163.1	regulates the succiny-lCoA synthetase operon
YP_688164.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_688165.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_688166.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_688167.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_688168.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_688169.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_688170.1	Code: C; COG: COG2142
YP_688171.1	Code: C; COG: COG2009
YP_688172.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_688173.1	Code: NU; COG: COG3539
YP_688174.1	Code: NU; COG: COG3188
YP_688175.1	Code: NU; COG: COG3121
YP_688177.1	5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity
YP_688178.1	Code: R; COG: COG1540
YP_688179.1	Code: E; COG: COG2049
YP_688180.1	Code: S; COG: COG0327
YP_688181.1	Code: E; COG: COG3104
YP_688182.1	UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent
YP_688183.1	Code: S; COG: COG3272
YP_688185.1	Code: M; COG: COG3209
YP_688187.1	Code: L; COG: COG1662
YP_688190.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_688191.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
YP_688192.1	response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport
YP_688194.1	catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system
YP_688195.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_688196.1	negative modulator of the initiation of chromosome replication
YP_688197.1	Code: R; COG: COG0596
YP_688199.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_688200.1	negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer
YP_688203.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_688204.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_688205.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_688206.1	catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate
YP_688207.1	Code: KG; COG: COG1940
YP_688208.1	Code: G; COG: COG0647
YP_688209.1	functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP
YP_688210.1	catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q
YP_688211.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_688212.1	Code: T; COG: COG1702
YP_688213.1	Code: R; COG: COG0319
YP_688214.1	Code: P; COG: COG4535
YP_688215.1	Transfers the fatty acyl group on membrane lipoproteins
YP_688216.1	Code: ET; COG: COG0834
YP_688217.1	Code: E; COG: COG0765
YP_688218.1	Code: E; COG: COG0765
YP_688219.1	Code: E; COG: COG1126
YP_688220.1	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific
YP_688221.1	Code: O; COG: COG0443
YP_688224.1	Code: R; COG: COG0790
YP_688227.1	Code: R; COG: COG0790
YP_688229.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_688230.1	a minor lipoprotein; rare lipoprotein B; involved in the assembly of LPS in the outer membrane
YP_688231.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_688232.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_688233.1	a phosphohistidine protein; Code: G; COG: COG0406
YP_688234.1	Code: S; COG: COG0799
YP_688235.1	SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_688236.1	Code: M; COG: COG0768
YP_688237.1	Code: D; COG: COG0772
YP_688238.1	a minor lipoprotein; Code: M; COG: COG0797
YP_688239.1	penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
YP_688240.1	Code: S; COG: COG2921
YP_688241.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_688242.1	Code: K; COG: COG0583
YP_688243.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_688244.1	TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_688245.1	Code: R; COG: COG0388
YP_688246.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_688247.1	member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator
YP_688248.1	catalyzes the transfer of palmitate to lipid A
YP_688249.1	responsible for the transport of C4-dicarboxylates during anaerobic growth
YP_688251.1	Code: L; COG: COG2801
YP_688252.1	Code: L; COG: COG2963
YP_688253.1	Code: L; COG: COG2801
YP_688259.1	Code: L; COG: COG2801
YP_688260.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688263.1	Code: L; COG: COG2963
YP_688267.1	Code: L; COG: COG3436
YP_688268.1	Code: L; COG: COG3436
YP_688270.1	Code: R; COG: COG3772
YP_688271.1	Code: L; COG: COG2963
YP_688272.1	Code: L; COG: COG2801
YP_688276.1	Code: S; COG: COG1636
YP_688282.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_688283.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688285.1	Code: L; COG: COG2801
YP_688286.1	Code: L; COG: COG2963
YP_688288.1	Code: S; COG: COG4886
YP_688289.1	catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
YP_688290.1	Code: S; COG: COG2828
YP_688291.1	Code: P; COG: COG0471
YP_688292.1	Code: C; COG: COG1048
YP_688293.1	outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase
YP_688294.1	YbhB; similar to rat and human kinase inhibitory proteins
YP_688295.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_688296.1	Code: H; COG: COG0502
YP_688297.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_688298.1	methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth
YP_688299.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_688300.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_688301.1	Code: S; COG: COG0391
YP_688302.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_688303.1	Code: H; COG: COG0521
YP_688304.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_688305.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_688306.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_688307.1	Code: R; COG: COG0670
YP_688308.1	Code: R; COG: COG0670
YP_688309.1	Code: S; COG: COG0392
YP_688310.1	Code: I; COG: COG1502
YP_688311.1	Code: R; COG: COG3568
YP_688313.1	Code: V; COG: COG0842
YP_688314.1	Code: V; COG: COG1131
YP_688315.1	Code: M; COG: COG0845
YP_688316.1	Code: K; COG: COG1309
YP_688317.1	this helicase is not essential cell growth
YP_688318.1	Code: S; COG: COG3236
YP_688319.1	helicase involved in DNA repair and perhaps also replication
YP_688320.1	Code: E; COG: COG0547
YP_688321.1	Code: C; COG: COG2055
YP_688323.1	Code: T; COG: COG1734
YP_688324.1	Code: S; COG: COG3128
YP_688325.1	Code: L; COG: COG3385
YP_688327.1	Code: R; COG: COG3129
YP_688329.1	similar to ATP-binding component of ABC transporters
YP_688330.1	similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine
YP_688331.1	similar to periplasmic-binding component of ABC transporters
YP_688332.1	binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage
YP_688333.1	Code: R; COG: COG5006
YP_688334.1	OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains
YP_688335.1	Code: R; COG: COG2194
YP_688336.1	Transcriptional regulator that represses the manganese transporter MntH when manganese is present
YP_688337.1	Code: P; COG: COG0471
YP_688338.1	Code: S; COG: COG1376
YP_688339.1	Code: R; COG: COG0488
YP_688341.1	Code: R; COG: COG0561
YP_688342.1	Code: C; COG: COG1882
YP_688343.1	Code: O; COG: COG1180
YP_688344.2	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_688345.1	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase
YP_688346.1	is involved in the formation of active molybdenum cofactor and the chelation of molybdenum
YP_688347.1	Code: E; COG: COG1446
YP_688348.1	with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains
YP_688349.1	Code: E; COG: COG0747
YP_688350.1	Code: EP; COG: COG0601
YP_688353.1	catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit
YP_688354.1	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_688355.1	Code: O; COG: COG0625
YP_688356.1	Code: L; COG: COG2963
YP_688357.1	Code: L; COG: COG2801
YP_688358.1	Code: KG; COG: COG1349
YP_688359.1	Code: I; COG: COG0671
YP_688360.1	Code: GEPR; COG: COG0477
YP_688362.1	Code: R; COG: COG0561
YP_688363.1	Code: GEPR; COG: COG0477
YP_688364.1	Code: S; COG: COG3226
YP_688365.1	Code: R; COG: COG2985
YP_688367.1	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_688368.1	YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function
YP_688369.1	NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds
YP_688370.1	responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6
YP_688372.1	Code: E; COG: COG0687
YP_688373.1	Code: E; COG: COG1176
YP_688374.1	Code: E; COG: COG1177
YP_688376.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_688377.1	Code: ET; COG: COG0834
YP_688378.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_688379.1	with ArtPMJI transports arginine across the inner membrane
YP_688380.1	Code: ET; COG: COG0834
YP_688381.1	With ArtMQJI transports arginine across the inner membrane
YP_688382.1	induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS
YP_688384.1	Code: L; COG: COG1662
YP_688386.1	Code: S; COG: COG0393
YP_688387.1	Code: V; COG: COG3023
YP_688388.1	Code: MG; COG: COG0451
YP_688389.1	Code: MG; COG: COG0702
YP_688390.1	low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine
YP_688391.1	catalyzes the formation of acetate from pyruvate
YP_688392.1	Code: C; COG: COG1018
YP_688393.1	catalyzes the reduction of hydroxylamine to ammonia and water
YP_688394.1	Code: S; COG: COG2431
YP_688395.1	porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure
YP_688396.1	Code: L; COG: COG1662
YP_688398.1	Code: L; COG: COG3593
YP_688399.1	Code: S; COG: COG2990
YP_688401.1	confers macrolide resistance via active drug efflux
YP_688402.1	inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible
YP_688403.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_688404.1	ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates
YP_688405.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_688406.1	leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys
YP_688407.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_688408.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_688409.1	catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding
YP_688410.1	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_688411.1	DNA-binding membrane protein required for chromosome resolution and partitioning
YP_688412.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_688413.1	Code: L; COG: COG2256
YP_688414.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_688415.1	Code: C; COG: COG0437
YP_688416.1	Code: R; COG: COG3302
YP_688417.1	Code: Q; COG: COG1335
YP_688418.1	Code: GEPR; COG: COG0477
YP_688420.1	Code: L; COG: COG3436
YP_688422.1	Code: L; COG: COG2963
YP_688423.1	Code: L; COG: COG2801
YP_688426.1	Code: L; COG: COG1662
YP_688427.1	Code: K; COG: COG0583
YP_688428.1	Code: L; COG: COG2963
YP_688429.1	Code: L; COG: COG2801
YP_688430.1	activates pyruvate formate-lyase 1 under anaerobic conditions
YP_688431.1	Code: C; COG: COG1882
YP_688432.1	Code: P; COG: COG2116
YP_688433.1	Code: S; COG: COG1944
YP_688434.2	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_688435.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_688436.1	Code: L; COG: COG3385
YP_688437.1	Code: O; COG: COG0501
YP_688438.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_688439.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_688440.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_688441.1	Code: R; COG: COG0658
YP_688442.1	multicopy suppressor of htrB; involved in the transport of lipid A across the inner membrane
YP_688443.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_688444.1	Code: S; COG: COG3214
YP_688445.1	Code: S; COG: COG2835
YP_688446.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_688448.1	Code: S; COG: COG1434
YP_688449.1	involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA
YP_688450.1	acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_688451.1	acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_688452.1	SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects
YP_688453.1	Code: L; COG: COG3385
YP_688454.1	Code: S; COG: COG2989
YP_688455.1	Code: S; COG: COG3108
YP_688456.1	Code: R; COG: COG0491
YP_688457.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_688458.1	outer membrane porin F; 1a; Ia; b
YP_688459.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_688460.1	catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate
YP_688461.1	Code: E; COG: COG0308
YP_688462.1	part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease
YP_688463.1	Code: P; COG: COG0600
YP_688464.1	Code: L; COG: COG2801
YP_688465.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688466.1	catalyzes the release of sulfite from alkanesulfonates
YP_688467.1	part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease
YP_688468.1	Code: R; COG: COG0431
YP_688470.1	Code: L; COG: COG1662
YP_688471.1	Code: NU; COG: COG3539
YP_688475.1	Code: NU; COG: COG3121
YP_688476.1	Code: NU; COG: COG3188
YP_688477.1	Code: NU; COG: COG3539
YP_688478.1	Code: NU; COG: COG3539
YP_688479.1	Code: NU; COG: COG3539
YP_688480.1	Code: NU; COG: COG3121
YP_688481.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_688483.1	Code: R; COG: COG3217
YP_688484.1	catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_688485.1	Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
YP_688486.1	Code: S; COG: COG2995
YP_688487.1	Code: R; COG: COG3008
YP_688488.1	Code: S; COG: COG3009
YP_688489.2	catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP
YP_688490.1	Code: O; COG: COG1067
YP_688491.1	Code: S; COG: COG3120
YP_688492.1	OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d
YP_688493.1	Code: D; COG: COG5404
YP_688494.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688495.1	Code: L; COG: COG2801
YP_688496.1	Code: S; COG: COG1289
YP_688497.1	Code: S; COG: COG3304
YP_688498.1	catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand
YP_688499.1	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_688500.1	Code: S; COG: COG3110
YP_688501.1	Code: R; COG: COG1832
YP_688502.1	Code: S; COG: COG3785
YP_688503.1	Code: R; COG: COG1092
YP_688504.1	transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs
YP_688505.1	Code: R; COG: COG0670
YP_688506.1	Code: C; COG: COG1740
YP_688507.1	involved in hydrogen cycling during fermentative growth
YP_688508.1	Code: C; COG: COG1969
YP_688509.1	HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1)
YP_688510.1	involved in processing hydrogenases HyaA and HyaB
YP_688512.1	Code: C; COG: COG1271
YP_688513.1	Code: C; COG: COG1294
YP_688515.1	Code: M; COG: COG3206
YP_688516.1	Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk
YP_688517.1	Code: M; COG: COG1596
YP_688522.1	Code: K; COG: COG1278
YP_688524.1	Code: L; COG: COG1662
YP_688525.1	Code: K; COG: COG1278
YP_688527.1	Code: C; COG: COG0348
YP_688529.1	periplasmic sensory protein associated with the TorRS two-component regulatory system
YP_688530.1	response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes
YP_688531.1	Code: C; COG: COG3005
YP_688532.1	Code: C; COG: COG0243
YP_688533.1	Code: L; COG: COG1662
YP_688535.1	with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA
YP_688536.1	functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock
YP_688540.1	stationary phase that binds TrpR repressor
YP_688542.1	Code: F; COG: COG2233
YP_688543.1	Code: R; COG: COG1853
YP_688544.1	Code: C; COG: COG0778
YP_688545.1	Code: R; COG: COG0596
YP_688546.1	Code: J; COG: COG0251
YP_688547.1	Code: Q; COG: COG1335
YP_688548.1	Code: C; COG: COG2141
YP_688549.1	Code: K; COG: COG1309
YP_688552.1	Code: P; COG: COG0672
YP_688553.1	Code: P; COG: COG2822
YP_688554.1	Code: P; COG: COG2837
YP_688555.1	in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export
YP_688556.1	predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein
YP_688557.1	Code: L; COG: COG1662
YP_688560.1	Code: L; COG: COG2801
YP_688561.1	Code: L; COG: COG2963
YP_688564.1	Code: ER; COG: COG1387
YP_688565.1	Code: R; COG: COG3381
YP_688567.1	nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_688568.1	chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_688569.1	activates the csgBA and csgDEFG operons involved in biofilm formation
YP_688570.1	CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface
YP_688571.1	Code: L; COG: COG2963
YP_688572.1	Code: L; COG: COG2801
YP_688574.1	Code: R; COG: COG2110
YP_688575.1	required for the transfer of succinyl residues to the glucan backbone
YP_688576.1	involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan
YP_688577.1	necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space
YP_688581.1	Code: L; COG: COG2801
YP_688582.1	Code: L; COG: COG2963
YP_688583.1	Code: L; COG: COG2963
YP_688585.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688586.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_688587.1	Code: L; COG: COG2963
YP_688590.1	Code: L; COG: COG2963
YP_688591.1	Code: L; COG: COG2801
YP_688592.1	Code: L; COG: COG1961
YP_688593.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_688594.1	Code: R; COG: COG1054
YP_688595.1	Code: S; COG: COG2353
YP_688596.1	Code: C; COG: COG3038
YP_688598.1	catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids
YP_688600.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_688602.1	cofactor involved in the reduction of disulfides
YP_688603.1	Confers resistance to norfloxacin and enoxacin
YP_688604.1	Code: J; COG: COG1670
YP_688605.1	Code: S; COG: COG3132
YP_688606.1	Code: R; COG: COG0673
YP_688607.1	Code: R; COG: COG0728
YP_688608.1	Code: NUO; COG: COG3418
YP_688609.1	regulates the flagellar specific sigma28 transcription factor
YP_688610.1	required for the assembly of the flagellar basal body P-ring
YP_688611.1	with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella
YP_688612.1	acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production
YP_688613.1	the hook connects flagellar basal body to the flagellar filament
YP_688614.1	FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod
YP_688615.1	makes up the distal portion of the flagellar basal body rod
YP_688616.1	part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod
YP_688617.1	part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum
YP_688618.2	Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
YP_688619.1	with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes
YP_688620.1	membrane attachment, mRNA turnover, maturation 5S RNA; bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase
YP_688621.1	catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA
YP_688622.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_688623.1	Code: R; COG: COG1399
YP_688624.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_688625.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_688626.1	Code: I; COG: COG0331
YP_688627.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_688628.1	carries the fatty acid chain in fatty acid biosynthesis
YP_688629.2	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_688630.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_688631.1	Code: R; COG: COG1559
YP_688632.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_688633.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_688634.1	Code: L; COG: COG0084
YP_688635.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_688636.1	Code: P; COG: COG4773
YP_688637.1	Code: FGR; COG: COG0537
YP_688638.1	Code: R; COG: COG5633
YP_688639.1	Code: R; COG: COG3417
YP_688640.1	catalyzes the phosphorylation of thiamine to thiamine phosphate
YP_688641.1	hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_688642.1	Code: R; COG: COG3150
YP_688643.1	Code: C; COG: COG1252
YP_688644.1	Code: S; COG: COG3134
YP_688645.1	Code: K; COG: COG1309
YP_688647.1	Code: S; COG: COG1376
YP_688648.1	Code: LK; COG: COG1197
YP_688649.1	Code: S; COG: COG4763
YP_688650.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_688651.1	outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone
YP_688652.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_688653.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_688654.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_688655.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate
YP_688656.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_688657.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_688658.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_688659.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_688660.1	Code: S; COG: COG2850
YP_688661.1	Code: L; COG: COG0582
YP_688664.1	Code: R; COG: COG3378
YP_688668.1	Code: L; COG: COG1662
YP_688670.1	Code: R; COG: COG3740
YP_688671.1	Code: S; COG: COG4695
YP_688673.1	Code: L; COG: COG3747
YP_688674.1	Code: R; COG: COG4626
YP_688677.1	Code: T; COG: COG0642
YP_688678.1	response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress
YP_688679.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_688680.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_688681.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_688682.1	Code: LR; COG: COG0494
YP_688683.1	catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA
YP_688684.1	Converts isocitrate to alpha ketoglutarate
YP_688685.1	Code: L; COG: COG1662
YP_688691.1	works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_688692.1	ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums
YP_688693.2	blocks the formation of polar Z-ring septums
YP_688694.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_688695.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688697.1	Code: L; COG: COG2963
YP_688698.1	Code: L; COG: COG2801
YP_688699.1	Code: S; COG: COG3100
YP_688700.1	Code: Q; COG: COG0179
YP_688701.2	Code: S; COG: COG2983
YP_688702.1	binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_688703.1	binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_688704.1	disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein
YP_688705.1	involved in regulation of intracellular pH under alkaline conditions
YP_688706.1	Multifunctional regulator of fatty acid metabolism
YP_688707.1	Code: S; COG: COG2719
YP_688708.1	catalyzes the oxidative deamination of D-amino acids
YP_688709.1	catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA
YP_688710.1	possible fragment
YP_688711.1	the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
YP_688712.1	catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine
YP_688713.1	Code: M; COG: COG0741
YP_688714.1	Code: M; COG: COG5581
YP_688715.1	Code: S; COG: COG2261
YP_688716.1	involved in molybdenum transport
YP_688717.1	Code: QR; COG: COG0500
YP_688718.1	Code: PH; COG: COG1120
YP_688719.1	Code: P; COG: COG0609
YP_688720.1	Code: P; COG: COG0614
YP_688722.1	periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell
YP_688723.1	phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL
YP_688724.1	with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone
YP_688725.1	with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase
YP_688726.1	Positively regulates the dhaKLM operon from a sigma-70 promoter
YP_688728.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_688729.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_688730.1	YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function
YP_688731.1	role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport
YP_688732.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_688733.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_688734.1	an enzyme in main pathway of synthesis of 5-aminolevulinate; Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_688735.1	enzyme in alternate path of synthesis of 5-aminolevulinate; catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_688736.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_688737.1	HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB
YP_688738.1	Code: S; COG: COG3094
YP_688739.1	Code: S; COG: COG2912
YP_688740.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_688741.1	Code: L; COG: COG3385
YP_688743.1	Code: P; COG: COG0387
YP_688744.1	in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions
YP_688745.1	Code: P; COG: COG3703
YP_688746.1	Code: P; COG: COG1553
YP_688748.1	two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase
YP_688749.1	acts on NarL regulator; Code: T; COG: COG3850
YP_688750.1	Code: P; COG: COG2223
YP_688751.1	Code: C; COG: COG5013
YP_688752.1	Code: C; COG: COG1140
YP_688753.1	Code: C; COG: COG2180
YP_688754.1	Code: C; COG: COG2181
YP_688755.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_688756.1	Code: S; COG: COG3012
YP_688757.1	Code: R; COG: COG1752
YP_688759.1	together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_688760.1	Code: R; COG: COG2916
YP_688761.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_688762.1	Code: L; COG: COG3385
YP_688763.1	Code: C; COG: COG1012
YP_688764.1	Code: U; COG: COG2095
YP_688765.1	Code: E; COG: COG4166
YP_688766.1	Code: EP; COG: COG0601
YP_688767.1	Code: EP; COG: COG1173
YP_688768.1	Code: EP; COG: COG0444
YP_688769.1	Code: E; COG: COG4608
YP_688770.1	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_688771.1	catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol)
YP_688772.1	Code: P; COG: COG1226
YP_688773.1	Code: L; COG: COG2963
YP_688774.1	Code: L; COG: COG2801
YP_688775.2	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_688776.1	membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins
YP_688777.1	YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase of proteins
YP_688778.1	Involved in cell division; probably involved in intracellular septation
YP_688780.1	receptor for colicin S4
YP_688781.1	Code: S; COG: COG3685
YP_688782.1	Code: S; COG: COG3685
YP_688783.1	Code: R; COG: COG3729
YP_688784.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_688785.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_688786.1	monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_688787.1	bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis
YP_688788.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_688789.1	Code: R; COG: COG0613
YP_688790.1	Code: J; COG: COG0009
YP_688791.1	catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA
YP_688792.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_688793.1	Code: IQR; COG: COG1028
YP_688794.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_688795.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_688796.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_688799.1	Catalyzes the conversion of citrate to isocitrate
YP_688800.1	catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate
YP_688801.1	Code: I; COG: COG0671
YP_688802.1	Code: S; COG: COG3771
YP_688803.1	Code: G; COG: COG2956
YP_688804.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_688805.1	involved in start site selection during the initiation of translation
YP_688807.1	Code: KG; COG: COG1349
YP_688809.1	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YP_688811.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_688812.1	Code: S; COG: COG2852
YP_688813.1	Code: V; COG: COG4167
YP_688814.1	Code: V; COG: COG4170
YP_688815.1	Code: V; COG: COG4171
YP_688816.1	Code: V; COG: COG4168
YP_688817.1	Code: E; COG: COG4166
YP_688819.1	Code: E; COG: COG0531
YP_688820.1	Code: E; COG: COG0174
YP_688821.1	Code: R; COG: COG2071
YP_688822.1	regulates genes involved in putrescine degradation
YP_688823.1	catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation
YP_688824.1	Code: E; COG: COG0665
YP_688825.1	putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate
YP_688826.1	transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor
YP_688827.1	involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF
YP_688828.1	acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding
YP_688829.1	with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock
YP_688831.1	rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide
YP_688832.1	Code: L; COG: COG1662
YP_688833.1	Code: G; COG: COG1175
YP_688834.1	Code: G; COG: COG0395
YP_688835.1	Code: ER; COG: COG1063
YP_688836.1	Code: G; COG: COG1554
YP_688837.1	Code: R; COG: COG0637
YP_688838.1	Code: G; COG: COG3839
YP_688839.1	Code: K; COG: COG1609
YP_688840.1	Code: R; COG: COG3106
YP_688841.1	Code: S; COG: COG3768
YP_688842.1	regulates genes involved in the biosynthesis and transport of aromatic amino acids
YP_688843.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_688844.1	Code: MR; COG: COG4948
YP_688845.1	Code: E; COG: COG2866
YP_688846.1	Code: MG; COG: COG0702
YP_688847.1	Code: R; COG: COG1073
YP_688848.1	Code: L; COG: COG3547
YP_688849.1	Code: R; COG: COG1073
YP_688850.1	Code: R; COG: COG1073
YP_688851.1	Code: L; COG: COG2801
YP_688852.1	Code: L; COG: COG2963
YP_688853.1	Code: L; COG: COG2963
YP_688855.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_688856.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_688858.1	Code: L; COG: COG1484
YP_688863.1	Code: L; COG: COG1662
YP_688869.1	Code: L; COG: COG1662
YP_688870.1	Code: L; COG: COG2801
YP_688875.1	Code: P; COG: COG1108
YP_688876.1	Code: P; COG: COG1108
YP_688877.1	Code: P; COG: COG1121
YP_688878.1	Code: P; COG: COG0803
YP_688881.1	Code: L; COG: COG1662
YP_688883.1	Code: L; COG: COG3436
YP_688884.1	Code: L; COG: COG3436
YP_688886.1	Code: S; COG: COG4886
YP_688887.1	Code: L; COG: COG2963
YP_688888.1	Code: L; COG: COG2801
YP_688891.1	in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA
YP_688892.1	Code: R; COG: COG3008
YP_688894.1	Code: S; COG: COG2995
YP_688895.1	Code: T; COG: COG1956
YP_688896.1	affects solute and DNA transport through an unknown mechanism
YP_688897.1	Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_688898.1	metalloprotease
YP_688899.1	Code: GEPR; COG: COG0477
YP_688900.1	Code: K; COG: COG1414
YP_688903.1	Code: K; COG: COG1278
YP_688904.1	methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth
YP_688905.1	Code: S; COG: COG1971
YP_688906.1	Code: L; COG: COG1662
YP_688907.1	Code: S; COG: COG4811
YP_688908.1	hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel
YP_688909.1	Code: G; COG: COG3715
YP_688913.1	Code: E; COG: COG1760
YP_688914.1	Code: LR; COG: COG0494
YP_688915.1	Code: EH; COG: COG0147
YP_688916.1	Code: S; COG: COG3140
YP_688918.1	Code: J; COG: COG0251
YP_688919.1	Code: KL; COG: COG1199
YP_688920.1	Code: O; COG: COG1214
YP_688921.1	Code: M; COG: COG3065
YP_688922.1	Activates fatty acids by binding to coenzyme A
YP_688923.1	Code: J; COG: COG0349
YP_688924.1	Code: C; COG: COG1018
YP_688926.1	Code: L; COG: COG2963
YP_688927.1	Code: L; COG: COG2801
YP_688930.1	Code: L; COG: COG1662
YP_688931.1	Code: M; COG: COG3713
YP_688932.1	Code: R; COG: COG0656
YP_688933.1	Code: G; COG: COG0676
YP_688934.1	Code: G; COG: COG0057
YP_688935.1	this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress
YP_688936.1	Code: S; COG: COG3139
YP_688937.1	Code: ER; COG: COG1063
YP_688938.1	Code: GEPR; COG: COG0477
YP_688939.1	Code: G; COG: COG0191
YP_688940.1	Code: G; COG: COG0524
YP_688941.1	Code: C; COG: COG0667
YP_688942.1	Code: KG; COG: COG1349
YP_688944.1	Code: L; COG: COG1662
YP_688945.1	catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide
YP_688946.1	converts asparagine to aspartate and ammonia
YP_688947.1	SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane
YP_688948.1	Code: C; COG: COG0778
YP_688949.1	catalyzes the formation of selenophosphate from selenide and ATP
YP_688950.1	decatenates replicating daughter chromosomes
YP_688952.1	Code: L; COG: COG1662
YP_688953.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_688955.1	Code: LR; COG: COG0494
YP_688956.1	Code: I; COG: COG0558
YP_688957.1	Code: R; COG: COG4136
YP_688959.1	Code: L; COG: COG3385
YP_688961.1	Code: S; COG: COG2128
YP_688962.1	Code: S; COG: COG0398
YP_688964.1	Code: S; COG: COG0398
YP_688965.1	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_688966.1	Code: E; COG: COG3138
YP_688967.1	a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH
YP_688968.1	catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism
YP_688969.1	related to spheroblast formation; periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP
YP_688970.1	Code: S; COG: COG3758
YP_688971.1	3' incision activity; acts with UvrC
YP_688972.1	prefers NH3 over glutamine; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_688973.1	osmotically-inducible lipoprotein E; activator of ntr-like gene protein
YP_688974.1	for cellobiose, arbutin, and salicin; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_688975.1	for cellobiose, arbutin, and salicin; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_688976.1	for cellobiose, arbutin, and salicin; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_688977.1	Code: G; COG: COG1486
YP_688978.1	Code: S; COG: COG3394
YP_688979.1	hydroperoxidase HPII(III); Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide
YP_688981.1	Code: R; COG: COG1988
YP_688982.1	YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate
YP_688984.1	Code: G; COG: COG3001
YP_688986.1	Code: G; COG: COG1105
YP_688987.1	Code: M; COG: COG3137
YP_688989.1	Code: L; COG: COG1662
YP_688991.1	catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_688992.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_688993.1	Code: J; COG: COG0291
YP_688994.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_688996.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_688997.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_688998.1	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
YP_688999.1	with BtuD and BtuF transports vitamin B12 into the cell
YP_689000.1	similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane
YP_689001.1	ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell
YP_689002.1	Code: M; COG: COG0791
YP_689003.1	Code: L; COG: COG3385
YP_689004.1	Code: T; COG: COG2200
YP_689005.1	Code: S; COG: COG0397
YP_689006.1	Code: P; COG: COG4256
YP_689007.1	tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate
YP_689008.1	Code: S; COG: COG1806
YP_689009.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_689010.1	acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids
YP_689011.1	Code: C; COG: COG2440
YP_689012.1	Code: C; COG: COG0644
YP_689013.1	May play a role in a redox process
YP_689014.1	YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_689017.1	Code: L; COG: COG1662
YP_689018.1	regulates the cellular response to acid resistance
YP_689019.1	in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase
YP_689022.1	Code: L; COG: COG1662
YP_689023.1	Code: L; COG: COG2801
YP_689028.1	Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor
YP_689029.1	Code: L; COG: COG2801
YP_689030.1	Code: L; COG: COG2963
YP_689031.1	Code: GEPR; COG: COG0477
YP_689032.1	Code: G; COG: COG0246
YP_689034.1	Code: K; COG: COG1802
YP_689035.1	NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine
YP_689036.1	Code: E; COG: COG0339
YP_689037.1	Code: R; COG: COG1546
YP_689040.1	Code: L; COG: COG2801
YP_689045.1	Code: S; COG: COG1742
YP_689046.1	Code: MR; COG: COG4948
YP_689047.1	Code: L; COG: COG2963
YP_689048.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_689050.1	Code: K; COG: COG2390
YP_689051.1	Code: G; COG: COG1129
YP_689052.1	Code: G; COG: COG1172
YP_689053.1	Code: G; COG: COG1172
YP_689054.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689055.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_689056.1	Code: G; COG: COG1830
YP_689057.1	Code: S; COG: COG1359
YP_689058.1	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate
YP_689059.1	Code: S; COG: COG3781
YP_689062.1	catalyzes the formation of D-tagaturonate from D-altronate
YP_689065.1	Code: E; COG: COG2066
YP_689067.1	Code: L; COG: COG1662
YP_689069.1	Code: G; COG: COG2814
YP_689070.1	protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function
YP_689071.1	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
YP_689072.2	transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF
YP_689074.1	Code: GER; COG: COG0697
YP_689075.1	Code: GEPR; COG: COG0477
YP_689076.1	Code: L; COG: COG2801
YP_689080.1	Code: L; COG: COG2963
YP_689081.1	Code: L; COG: COG2801
YP_689084.1	Code: C; COG: COG0437
YP_689085.1	Code: R; COG: COG3302
YP_689086.1	Code: P; COG: COG0038
YP_689087.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_689088.1	Code: KG; COG: COG1940
YP_689089.1	Code: K; COG: COG0583
YP_689090.1	required for growth and survival under moderately acid conditions
YP_689091.1	Code: E; COG: COG3591
YP_689092.1	with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS
YP_689093.1	with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS
YP_689094.1	transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes
YP_689095.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_689096.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_689098.1	Code: E; COG: COG0531
YP_689099.1	Code: IQR; COG: COG1028
YP_689100.1	Code: R; COG: COG3136
YP_689101.1	response regulator in two-component regulatory system with RstB
YP_689102.1	Code: R; COG: COG1823
YP_689103.1	Code: T; COG: COG0642
YP_689104.1	binds to DNA replication terminator sequences to prevent passage of replication forks
YP_689105.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_689106.1	Code: C; COG: COG1951
YP_689107.1	Code: G; COG: COG1482
YP_689108.1	Code: S; COG: COG5339
YP_689110.1	Code: G; COG: COG3250
YP_689111.1	Code: K; COG: COG1309
YP_689112.1	Code: L; COG: COG1662
YP_689113.1	regulates malXY which are involved in maltose-glucose transport
YP_689114.1	phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site
YP_689115.1	Code: E; COG: COG1168
YP_689116.1	catalyzes the formation of inosine from adenosine
YP_689117.1	Code: R; COG: COG0673
YP_689118.1	YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes
YP_689120.1	Code: C; COG: COG4657
YP_689121.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_689122.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_689123.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_689124.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_689125.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_689126.1	DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines
YP_689127.1	mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation
YP_689128.1	Code: O; COG: COG0625
YP_689129.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_689130.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_689131.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_689132.1	Code: R; COG: COG3895
YP_689133.1	Code: L; COG: COG2801
YP_689134.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689135.1	catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_689136.1	Code: M; COG: COG3133
YP_689137.1	Transcription regulator that can both activate or repress expression
YP_689139.1	Code: V; COG: COG1566
YP_689141.1	Code: S; COG: COG1289
YP_689142.1	SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water
YP_689143.1	Code: R; COG: COG4989
YP_689145.1	Code: K; COG: COG1309
YP_689146.1	FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide
YP_689147.1	Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione
YP_689148.1	degrades tRNA; Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_689149.1	Code: R; COG: COG1201
YP_689151.1	Code: L; COG: COG0675
YP_689152.1	Code: O; COG: COG0278
YP_689153.1	Code: M; COG: COG0791
YP_689154.1	SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals
YP_689155.1	Code: G; COG: COG2814
YP_689156.1	binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers
YP_689157.1	Code: K; COG: COG0583
YP_689158.1	uncharacterized member of the major facilitator superfamily (MFS)
YP_689159.1	catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
YP_689160.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_689161.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_689162.1	Code: MU; COG: COG3468
YP_689164.1	Code: S; COG: COG4529
YP_689166.1	Code: C; COG: COG4117
YP_689167.1	Code: C; COG: COG0437
YP_689169.1	Code: C; COG: COG2414
YP_689170.1	Code: C; COG: COG0437
YP_689172.1	Code: L; COG: COG1662
YP_689173.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_689174.1	Code: M; COG: COG4238
YP_689175.1	Code: S; COG: COG1376
YP_689176.1	Acts with SufS to catalyze the formation of L-alanine from L-cysteine
YP_689177.1	catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine
YP_689178.1	with SufBC activates cysteine desulfurase SufS
YP_689179.1	part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE
YP_689180.1	with SufCD activates cysteine desulfurase SufS
YP_689181.1	functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein
YP_689183.1	Code: Q; COG: COG2050
YP_689185.1	YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function
YP_689187.1	Code: L; COG: COG1662
YP_689188.1	Code: GEPR; COG: COG0477
YP_689190.1	Code: L; COG: COG1662
YP_689191.1	Code: E; COG: COG0169
YP_689192.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_689193.1	Code: L; COG: COG1662
YP_689195.1	Code: P; COG: COG3119
YP_689196.1	Code: R; COG: COG0641
YP_689198.1	Code: L; COG: COG1662
YP_689200.1	Code: L; COG: COG1662
YP_689201.1	Code: E; COG: COG0076
YP_689202.1	Code: E; COG: COG0531
YP_689203.1	Code: S; COG: COG1649
YP_689205.1	Code: T; COG: COG2200
YP_689207.1	Code: EP; COG: COG1173
YP_689208.1	Code: EP; COG: COG0444
YP_689209.1	Code: EP; COG: COG1124
YP_689210.1	Code: O; COG: COG1764
YP_689211.1	Code: L; COG: COG1662
YP_689213.1	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_689214.1	Code: R; COG: COG3093
YP_689215.1	nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase
YP_689216.1	Code: C; COG: COG0437
YP_689217.1	Code: C; COG: COG0243
YP_689218.1	Code: GER; COG: COG0697
YP_689219.1	Code: L; COG: COG1662
YP_689221.1	Code: M; COG: COG3203
YP_689222.1	Code: S; COG: COG4886
YP_689223.1	Code: S; COG: COG4886
YP_689225.1	Code: L; COG: COG1662
YP_689226.1	Code: P; COG: COG2223
YP_689227.1	Code: C; COG: COG5013
YP_689231.1	Code: K; COG: COG1802
YP_689232.1	Code: R; COG: COG2130
YP_689233.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_689234.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689235.1	Code: S; COG: COG3238
YP_689239.1	catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation
YP_689240.1	Code: E; COG: COG1177
YP_689242.1	Code: L; COG: COG0675
YP_689244.1	with TehA confers resistance to tellurite
YP_689245.1	Code: P; COG: COG1275
YP_689247.1	Code: J; COG: COG1670
YP_689248.1	Code: S; COG: COG2841
YP_689249.1	involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans
YP_689250.1	Code: S; COG: COG5383
YP_689251.1	Code: K; COG: COG0583
YP_689252.1	ribose sensor receptor; Code: NT; COG: COG0840
YP_689253.1	Code: L; COG: COG2963
YP_689254.1	Code: L; COG: COG2801
YP_689255.1	Code: L; COG: COG2963
YP_689257.2	B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm
YP_689258.1	Code: G; COG: COG0057
YP_689259.1	NAD-linked
YP_689261.1	Code: L; COG: COG2801
YP_689262.1	involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
YP_689263.1	FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds
YP_689264.1	Code: L; COG: COG2963
YP_689265.1	Code: L; COG: COG2801
YP_689267.1	Code: R; COG: COG4589
YP_689268.1	Code: I; COG: COG0558
YP_689270.1	Code: L; COG: COG1662
YP_689271.1	Code: O; COG: COG3187
YP_689272.1	Code: CHR; COG: COG1052
YP_689276.1	Code: L; COG: COG1662
YP_689278.1	Code: T; COG: COG0589
YP_689279.1	TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs
YP_689280.1	exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA
YP_689281.1	Code: P; COG: COG0598
YP_689283.1	Code: S; COG: COG2840
YP_689288.1	Code: K; COG: COG2207
YP_689289.1	Code: L; COG: COG0350
YP_689290.1	Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_689291.1	with UspC and UspD is involved in resistance to UV irradiation
YP_689294.1	Code: L; COG: COG2963
YP_689295.1	Code: M; COG: COG0668
YP_689296.1	Code: E; COG: COG4166
YP_689297.1	Code: L; COG: COG2963
YP_689298.1	Code: L; COG: COG2801
YP_689301.1	Code: L; COG: COG2963
YP_689302.1	Code: L; COG: COG2801
YP_689303.1	Code: L; COG: COG0582
YP_689305.1	Code: P; COG: COG1276
YP_689306.1	Code: R; COG: COG2372
YP_689308.1	Code: R; COG: COG0388
YP_689309.1	3'-5' exonuclease activity on single or double-strand DNA
YP_689310.1	PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues
YP_689311.1	Code: S; COG: COG2979
YP_689312.1	secreted protein; unknown function
YP_689313.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_689314.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_689315.1	catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate
YP_689316.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_689317.1	Represses the expression of the zwf, eda, glp and gap
YP_689318.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_689319.1	Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_689320.1	Code: M; COG: COG0739
YP_689321.1	involved in transport of zinc(II) with ZnuA and C
YP_689322.1	involved in transport of zinc(II) with ZnuA and C
YP_689323.1	involved in transport of zinc(II) with ZnuA and C
YP_689324.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_689325.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_689327.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_689328.1	Code: S; COG: COG0217
YP_689329.1	converts dATP to dAMP and pyrophosphate
YP_689330.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_689331.1	Code: L; COG: COG3547
YP_689333.1	Code: S; COG: COG4886
YP_689335.1	Code: M; COG: COG3637
YP_689336.1	Code: S; COG: COG4733
YP_689337.1	Code: S; COG: COG4723
YP_689339.1	Code: S; COG: COG4672
YP_689342.1	Code: N; COG: COG5492
YP_689347.1	Code: L; COG: COG3547
YP_689349.1	Code: L; COG: COG4570
YP_689351.1	Code: L; COG: COG2963
YP_689352.1	Code: L; COG: COG2801
YP_689353.1	Code: L; COG: COG2801
YP_689354.1	Code: L; COG: COG2963
YP_689361.1	Code: R; COG: COG3788
YP_689362.1	Code: QR; COG: COG0500
YP_689363.1	Code: QR; COG: COG0500
YP_689364.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689365.1	Code: L; COG: COG2801
YP_689366.1	Code: C; COG: COG3005
YP_689367.1	Code: P; COG: COG3142
YP_689368.1	Code: S; COG: COG3102
YP_689369.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_689370.1	Code: S; COG: COG3755
YP_689373.1	Code: L; COG: COG2963
YP_689375.2	membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export
YP_689377.1	Code: L; COG: COG2963
YP_689380.1	Code: L; COG: COG2801
YP_689381.1	cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation
YP_689382.1	chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
YP_689383.1	regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins
YP_689384.1	methylates the MCP
YP_689385.1	mediates taxis toward dipeptides
YP_689386.1	Code: NT; COG: COG0840
YP_689387.1	Code: NT; COG: COG0835
YP_689388.1	chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component
YP_689389.1	with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_689390.1	With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_689391.1	With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems
YP_689392.1	ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_689393.1	biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature
YP_689394.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_689396.1	Code: G; COG: COG1879
YP_689397.1	Code: P; COG: COG1528
YP_689401.1	cytoplasmic iron storage protein
YP_689403.1	Code: E; COG: COG0814
YP_689404.1	Code: R; COG: COG3318
YP_689405.1	Code: I; COG: COG0558
YP_689406.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_689407.1	in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system
YP_689409.1	Code: K; COG: COG2771
YP_689410.1	Code: E; COG: COG1126
YP_689411.1	Code: E; COG: COG0765
YP_689412.1	catalyzes the formation of pyruvate from D-cysteine
YP_689413.1	Code: ET; COG: COG0834
YP_689414.1	expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence
YP_689415.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes
YP_689416.1	structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes
YP_689417.1	involved in flagellin assembly
YP_689418.1	flagellin specific chaperone
YP_689419.1	binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family
YP_689420.1	converts 1,4-alpha-D-glucans to maltodextrin
YP_689422.1	Code: R; COG: COG2391
YP_689423.1	Code: O; COG: COG0425
YP_689424.1	Code: L; COG: COG0675
YP_689425.1	Code: M; COG: COG3203
YP_689426.1	Code: K; COG: COG2207
YP_689427.1	member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation
YP_689428.1	forms a junction between the M-ring and FlgB during flagella biosynthesis
YP_689429.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_689430.1	binds to and inhibits the function of flagella specific ATPase FliI
YP_689431.1	involved in type III protein export during flagellum assembly
YP_689432.1	Code: N; COG: COG3144
YP_689433.1	interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring
YP_689434.1	with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation
YP_689435.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_689436.1	with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus
YP_689437.1	FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus
YP_689438.1	with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus
YP_689439.1	FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus
YP_689440.1	Code: K; COG: COG2771
YP_689444.1	Code: S; COG: COG2354
YP_689445.1	Code: GER; COG: COG0697
YP_689446.1	Code: L; COG: COG3727
YP_689447.1	Code: L; COG: COG0270
YP_689448.1	Code: R; COG: COG1418
YP_689449.1	Code: L; COG: COG2801
YP_689450.1	Code: L; COG: COG2963
YP_689451.1	Code: M; COG: COG3203
YP_689452.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_689453.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689456.1	Code: L; COG: COG1662
YP_689457.1	Hsp31 stabilizes early unfolding protein intermediates under severe heat stress
YP_689458.1	Code: T; COG: COG0642
YP_689459.1	induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced
YP_689460.1	Code: R; COG: COG2351
YP_689461.1	in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme
YP_689462.1	Code: R; COG: COG3443
YP_689464.1	Code: QR; COG: COG0500
YP_689465.1	Code: S; COG: COG4886
YP_689467.1	Code: L; COG: COG2801
YP_689468.1	Code: L; COG: COG2963
YP_689471.1	Code: L; COG: COG3436
YP_689474.1	Code: L; COG: COG4570
YP_689478.1	Code: L; COG: COG1662
YP_689480.1	Code: L; COG: COG1662
YP_689482.1	Code: L; COG: COG0582
YP_689483.1	Code: S; COG: COG3228
YP_689486.1	Code: L; COG: COG2963
YP_689487.1	Code: L; COG: COG2963
YP_689488.1	Code: L; COG: COG2801
YP_689489.1	Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile
YP_689490.1	Code: S; COG: COG0217
YP_689493.1	LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB
YP_689494.1	Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation
YP_689495.1	Code: S; COG: COG1376
YP_689496.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_689497.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_689498.1	catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP
YP_689501.1	Code: L; COG: COG2801
YP_689502.1	Code: L; COG: COG0582
YP_689503.1	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
YP_689504.1	Code: O; COG: COG0425
YP_689505.1	Code: R; COG: COG2391
YP_689506.1	Code: E; COG: COG0531
YP_689507.1	Code: K; COG: COG0583
YP_689508.1	Code: MG; COG: COG0451
YP_689509.1	Code: S; COG: COG4115
YP_689510.1	Code: L; COG: COG1662
YP_689511.1	Antitoxin that counteracts the effect of the YoeB toxin
YP_689512.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_689513.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_689514.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_689515.1	catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate
YP_689516.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_689517.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_689518.1	imidazole glycerol phosphate synthase subunit in heterodimer with HisH; catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_689519.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_689520.1	Code: M; COG: COG3765
YP_689521.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_689527.1	Code: M; COG: COG1898
YP_689528.1	Code: M; COG: COG1209
YP_689529.1	with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose
YP_689530.1	NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose
YP_689531.1	together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_689532.1	Code: M; COG: COG0438
YP_689533.1	Code: S; COG: COG2327
YP_689534.1	Code: R; COG: COG2244
YP_689535.1	WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid
YP_689536.1	Code: M; COG: COG0836
YP_689537.1	Code: M; COG: COG0438
YP_689538.1	Code: LR; COG: COG0494
YP_689539.1	Code: MG; COG: COG0451
YP_689540.1	Code: M; COG: COG1089
YP_689541.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit)
YP_689543.1	Code: L; COG: COG1662
YP_689544.1	Code: M; COG: COG0463
YP_689545.1	essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance
YP_689546.1	Code: M; COG: COG0438
YP_689547.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium
YP_689548.1	Code: M; COG: COG0463
YP_689549.1	Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide)
YP_689550.1	Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis
YP_689551.1	Code: M; COG: COG1596
YP_689553.1	YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs
YP_689554.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_689555.1	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_689556.1	Code: L; COG: COG3547
YP_689557.1	Code: R; COG: COG4245
YP_689559.1	Code: R; COG: COG4248
YP_689560.1	Code: O; COG: COG0443
YP_689561.1	inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine
YP_689562.1	Code: L; COG: COG3547
YP_689563.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_689564.1	Code: V; COG: COG0841
YP_689566.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate
YP_689567.2	Code: GEPR; COG: COG0477
YP_689568.1	Code: T; COG: COG0642
YP_689569.1	response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport
YP_689570.1	Code: S; COG: COG3422
YP_689571.1	Code: O; COG: COG0826
YP_689573.1	cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role
YP_689574.1	Code: KG; COG: COG1349
YP_689575.1	Code: G; COG: COG3775
YP_689576.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_689577.1	Code: G; COG: COG4573
YP_689578.2	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_689579.1	catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate
YP_689580.1	Code: GEPR; COG: COG0477
YP_689581.1	Code: G; COG: COG0524
YP_689583.1	Code: M; COG: COG3757
YP_689584.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_689585.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_689586.1	Code: S; COG: COG1937
YP_689587.1	membrane protein conferring nickel and cobalt resistance
YP_689588.1	Code: S; COG: COG5455
YP_689590.1	Code: NU; COG: COG3188
YP_689591.1	Code: NU; COG: COG3121
YP_689592.1	Code: L; COG: COG1662
YP_689594.1	Code: NU; COG: COG3539
YP_689595.1	Code: D; COG: COG0489
YP_689596.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_689598.1	Code: L; COG: COG2801
YP_689601.1	Code: L; COG: COG1662
YP_689603.1	Code: S; COG: COG4808
YP_689604.1	Code: S; COG: COG4807
YP_689605.1	unknown function; when overproduced it confers drug-resistance
YP_689606.1	Code: T; COG: COG3275
YP_689607.1	Code: L; COG: COG3385
YP_689610.1	Code: QR; COG: COG0500
YP_689611.1	Code: S; COG: COG4886
YP_689616.1	Code: L; COG: COG1662
YP_689617.1	Code: NU; COG: COG3539
YP_689618.1	Code: L; COG: COG1662
YP_689621.1	Code: L; COG: COG2801
YP_689624.1	Code: L; COG: COG2963
YP_689625.1	Code: L; COG: COG2801
YP_689627.1	Code: E; COG: COG1174
YP_689628.1	Code: E; COG: COG1125
YP_689629.1	Code: E; COG: COG1174
YP_689630.1	Code: M; COG: COG1732
YP_689631.1	Code: G; COG: COG1472
YP_689632.1	component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_689633.1	specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7
YP_689635.1	Code: S; COG: COG0586
YP_689636.1	may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_689637.1	Code: J; COG: COG0042
YP_689638.1	Code: R; COG: COG1380
YP_689639.1	Code: M; COG: COG1346
YP_689640.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_689641.1	Code: S; COG: COG2949
YP_689643.1	function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain
YP_689644.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_689645.1	with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains
YP_689646.1	Code: G; COG: COG1879
YP_689647.1	negative regulator of the mglBAC operon for galactose utilization
YP_689648.1	Code: S; COG: COG2311
YP_689649.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_689650.1	Code: R; COG: COG0627
YP_689651.1	Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein
YP_689652.1	Code: E; COG: COG0833
YP_689653.1	Code: K; COG: COG0583
YP_689654.1	Code: S; COG: COG2855
YP_689655.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_689656.1	Code: G; COG: COG0524
YP_689657.1	Code: F; COG: COG1972
YP_689658.1	Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively
YP_689659.1	activator of nucleoside metabolism
YP_689660.1	Code: F; COG: COG1972
YP_689661.1	Code: Q; COG: COG2313
YP_689662.1	Code: G; COG: COG0524
YP_689663.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_689664.1	converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers
YP_689665.1	phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr
YP_689666.1	Code: GEPR; COG: COG0477
YP_689667.1	Code: L; COG: COG1662
YP_689668.1	Code: L; COG: COG3677
YP_689670.1	Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein
YP_689671.1	Code: G; COG: COG0246
YP_689672.1	Code: R; COG: COG0523
YP_689673.1	Code: I; COG: COG0671
YP_689674.1	by similarity, Spr seems to have peptidase activity; involved in thermoresistance
YP_689676.1	Code: E; COG: COG4166
YP_689677.1	Code: R; COG: COG4174
YP_689678.1	Code: R; COG: COG4239
YP_689679.1	Code: R; COG: COG4172
YP_689681.1	Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance
YP_689682.1	catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA
YP_689683.1	Code: KL; COG: COG1061
YP_689684.2	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_689685.1	Code: R; COG: COG3081
YP_689686.1	Code: S; COG: COG3082
YP_689687.1	Code: R; COG: COG3083
YP_689688.1	Code: MU; COG: COG3468
YP_689689.1	nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes
YP_689690.1	Code: O; COG: COG4235
YP_689691.1	Code: OC; COG: COG0526
YP_689692.1	Code: O; COG: COG1138
YP_689693.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_689694.1	Code: U; COG: COG3114
YP_689695.1	Code: O; COG: COG0755
YP_689696.1	Code: O; COG: COG2386
YP_689697.1	ATP-binding protein; required for proper cytochrome c maturation
YP_689698.1	with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone
YP_689699.1	small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA
YP_689700.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_689701.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_689702.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_689703.1	Code: P; COG: COG3062
YP_689704.1	serine protease inhibitor, inhibits trypsin and other proteases
YP_689705.1	efflux pump for the antibacterial peptide microcin J25
YP_689706.1	Code: L; COG: COG3145
YP_689708.1	catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway
YP_689709.1	allows for ions and hydrophilic solutes to cross the outer membrane
YP_689710.1	Code: T; COG: COG0642
YP_689711.1	two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF
YP_689712.1	Code: T; COG: COG0642
YP_689713.1	Code: S; COG: COG4676
YP_689714.1	Code: S; COG: COG5445
YP_689715.1	Code: L; COG: COG2801
YP_689716.1	Code: L; COG: COG2963
YP_689717.1	Code: S; COG: COG3234
YP_689718.1	Code: S; COG: COG4685
YP_689720.1	negatively supercoils closed circular double-stranded DNA
YP_689721.1	Involved in ubiquinone biosynthesis
YP_689722.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689723.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_689724.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_689725.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_689726.1	plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases
YP_689728.1	hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic
YP_689729.1	catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell
YP_689730.1	anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor
YP_689731.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_689732.1	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_689733.1	Code: S; COG: COG5464
YP_689736.1	Code: R; COG: COG1058
YP_689738.1	Code: LR; COG: COG0494
YP_689740.1	catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose
YP_689741.1	catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate
YP_689742.1	Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains
YP_689743.1	Code: G; COG: COG0726
YP_689744.2	catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A
YP_689745.1	Code: GER; COG: COG0697
YP_689747.1	Code: IQ; COG: COG0318
YP_689748.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_689749.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_689750.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_689751.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_689752.1	Code: HQ; COG: COG1169
YP_689753.1	Code: S; COG: COG4575
YP_689754.1	Code: R; COG: COG2153
YP_689755.1	member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_689757.1	Code: L; COG: COG1662
YP_689759.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689760.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689761.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_689762.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689763.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689764.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689765.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689766.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689767.1	shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase
YP_689768.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689769.1	NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms
YP_689770.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_689771.1	Catalyzes the transfer of electrons from NADH to quinone
YP_689772.1	Code: K; COG: COG0583
YP_689773.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_689774.1	Code: R; COG: COG1896
YP_689775.1	Code: P; COG: COG0471
YP_689776.1	Code: R; COG: COG0637
YP_689777.1	Code: S; COG: COG3013
YP_689778.1	Code: S; COG: COG3092
YP_689779.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_689780.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_689781.1	Code: S; COG: COG1288
YP_689782.1	Code: LR; COG: COG0494
YP_689783.1	Code: R; COG: COG0622
YP_689784.1	Code: O; COG: COG0625
YP_689785.1	Code: O; COG: COG0625
YP_689786.1	catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate
YP_689787.1	Code: R; COG: COG1090
YP_689788.1	Code: S; COG: COG5464
YP_689789.1	Code: E; COG: COG4598
YP_689790.1	Code: E; COG: COG4160
YP_689791.1	Code: E; COG: COG4215
YP_689792.1	Code: ET; COG: COG0834
YP_689793.1	Code: ET; COG: COG0834
YP_689794.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_689795.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689796.1	catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate
YP_689797.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_689798.1	membrane protein required for colicin V production
YP_689799.1	Code: S; COG: COG3147
YP_689800.1	Code: H; COG: COG0285
YP_689801.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_689802.1	Code: S; COG: COG0586
YP_689803.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_689804.1	Code: E; COG: COG0136
YP_689805.1	Code: HE; COG: COG0111
YP_689806.1	in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein
YP_689807.1	Code: GEPR; COG: COG0477
YP_689808.1	Code: IQ; COG: COG0304
YP_689809.1	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_689811.1	Code: S; COG: COG3101
YP_689812.1	Code: R; COG: COG0730
YP_689813.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_689814.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_689815.1	involved in methylation of ribosomal protein L3
YP_689816.1	Code: S; COG: COG2840
YP_689818.1	Code: NU; COG: COG3539
YP_689819.1	Code: NU; COG: COG3539
YP_689820.1	Code: NU; COG: COG3539
YP_689821.1	Code: NU; COG: COG3121
YP_689822.1	Code: NU; COG: COG3539
YP_689823.1	Code: T; COG: COG2062
YP_689824.1	multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate
YP_689825.1	FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth
YP_689826.1	Code: S; COG: COG3691
YP_689827.1	Code: I; COG: COG2067
YP_689829.1	Code: M; COG: COG2853
YP_689830.1	Code: P; COG: COG2116
YP_689833.1	Code: L; COG: COG2963
YP_689834.1	phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least
YP_689835.1	Code: L; COG: COG3385
YP_689836.1	Code: G; COG: COG1621
YP_689837.1	Code: K; COG: COG1609
YP_689839.1	catalyzes the formation of pyruvate from serine
YP_689840.1	Code: GEPR; COG: COG0477
YP_689841.1	Code: V; COG: COG1566
YP_689842.1	response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance
YP_689844.1	Code: C; COG: COG1804
YP_689845.1	member of the AEC family of auxin efflux transporters; unknown function
YP_689846.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_689847.1	catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA
YP_689850.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock
YP_689851.1	Code: E; COG: COG0436
YP_689852.1	Code: T; COG: COG3275
YP_689853.1	Code: KT; COG: COG3279
YP_689854.1	Code: K; COG: COG2207
YP_689855.1	Code: G; COG: COG1080
YP_689856.1	metalloprotein
YP_689857.1	Code: G; COG: COG1299
YP_689858.1	Code: G; COG: COG1445
YP_689859.1	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate
YP_689860.1	Code: P; COG: COG0038
YP_689862.1	Code: P; COG: COG1914
YP_689863.1	Code: F; COG: COG1972
YP_689867.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_689869.1	Code: K; COG: COG0583
YP_689870.1	Code: R; COG: COG0385
YP_689871.1	Code: S; COG: COG3530
YP_689872.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_689873.1	interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_689874.1	role in sulfur assimilation
YP_689875.1	O-acetylserine sulfhydrolase A; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis
YP_689876.1	Code: G; COG: COG1925
YP_689877.1	Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system
YP_689878.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_689879.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_689882.1	Code: S; COG: COG4884
YP_689883.1	catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide
YP_689884.1	Code: P; COG: COG1118
YP_689885.1	Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import
YP_689886.1	Code: O; COG: COG0555
YP_689887.1	Code: P; COG: COG4150
YP_689888.1	Code: IQR; COG: COG1028
YP_689889.1	Code: K; COG: COG1737
YP_689890.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_689891.1	belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component
YP_689892.1	Code: P; COG: COG2837
YP_689895.1	Code: R; COG: COG0456
YP_689896.1	Code: M; COG: COG0860
YP_689897.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_689898.1	activates the transcription of the ethanolamine utilization operon
YP_689899.1	Code: QC; COG: COG4577
YP_689900.1	Code: E; COG: COG4816
YP_689902.1	Code: L; COG: COG1662
YP_689908.1	Code: E; COG: COG0531
YP_689909.1	Code: M; COG: COG0796
YP_689910.1	Code: L; COG: COG1662
YP_689911.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_689912.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_689913.1	ethanolamine utilization protein EutA
YP_689914.1	Code: E; COG: COG4917
YP_689915.1	Code: E; COG: COG4810
YP_689916.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_689917.1	Code: G; COG: COG0176
YP_689918.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_689920.1	Code: LR; COG: COG0494
YP_689921.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_689922.1	Code: V; COG: COG0841
YP_689923.1	Code: P; COG: COG1393
YP_689924.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_689926.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_689927.1	Code: R; COG: COG1444
YP_689928.1	Code: R; COG: COG2321
YP_689929.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_689930.1	Code: M; COG: COG3317
YP_689931.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_689932.1	negative transcriptional regulator of the gcvTHP operon
YP_689933.1	bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine
YP_689934.1	Code: C; COG: COG1142
YP_689935.1	Code: C; COG: COG0650
YP_689936.1	Code: CP; COG: COG1009
YP_689937.1	interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide
YP_689938.1	Code: CP; COG: COG0651
YP_689939.1	probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far
YP_689940.1	Code: C; COG: COG3260
YP_689942.1	Code: KT; COG: COG3604
YP_689943.1	Code: R; COG: COG0628
YP_689944.1	Code: R; COG: COG4783
YP_689945.1	Code: P; COG: COG1393
YP_689946.1	controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP
YP_689947.1	Code: F; COG: COG2233
YP_689948.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_689949.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_689950.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_689951.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_689952.1	Code: FP; COG: COG0248
YP_689953.1	Code: L; COG: COG2963
YP_689954.1	Code: L; COG: COG2801
YP_689958.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_689959.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_689960.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_689962.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_689963.1	with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis
YP_689964.1	Code: S; COG: COG2976
YP_689965.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_689966.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_689967.1	Code: S; COG: COG1426
YP_689968.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_689969.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_689970.1	Code: M; COG: COG4953
YP_689973.1	enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I
YP_689974.1	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_689975.1	Code: S; COG: COG2975
YP_689976.1	Code: C; COG: COG0633
YP_689977.1	involved in the maturation of iron-sulfur cluster-containing proteins
YP_689978.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_689979.1	forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein
YP_689980.1	Code: C; COG: COG0822
YP_689981.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_689982.1	regulates the expression of the iscRSUA operon
YP_689983.1	Code: J; COG: COG0565
YP_689984.1	Code: G; COG: COG0483
YP_689985.1	Code: R; COG: COG1073
YP_689986.1	Code: K; COG: COG3711
YP_689987.1	transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_689988.1	activator of 3-phenylpropionic acid catabolism
YP_689989.1	Code: PR; COG: COG4638
YP_689990.1	Code: Q; COG: COG5517
YP_689991.1	Code: PR; COG: COG2146
YP_689992.1	Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate
YP_689993.1	Code: R; COG: COG0446
YP_689994.1	Code: S; COG: COG2259
YP_689995.1	Code: G; COG: COG2017
YP_689996.1	Code: ER; COG: COG1063
YP_689997.1	Code: G; COG: COG1172
YP_689998.1	Code: G; COG: COG1129
YP_689999.1	Code: G; COG: COG1879
YP_690000.1	Code: KG; COG: COG1940
YP_690001.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_690002.1	flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine
YP_690003.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA
YP_690004.1	Code: T; COG: COG2204
YP_690006.1	Code: T; COG: COG0642
YP_690007.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_690008.1	YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function
YP_690009.1	Code: FJ; COG: COG0590
YP_690010.1	Code: E; COG: COG0560
YP_690011.1	Code: K; COG: COG1737
YP_690012.1	Code: L; COG: COG1961
YP_690013.1	Code: S; COG: COG4886
YP_690018.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_690019.1	Code: L; COG: COG2801
YP_690023.1	Code: L; COG: COG2963
YP_690024.1	Code: L; COG: COG2801
YP_690026.1	Code: L; COG: COG1662
YP_690028.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_690029.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_690030.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_690031.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_690032.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_690033.1	catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins
YP_690034.1	may be inner membrane protein; binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_690035.1	involved in the reduction of the SoxR iron-sulfur cluster
YP_690036.1	periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
YP_690037.1	Code: T; COG: COG3073
YP_690038.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_690039.1	Code: R; COG: COG4123
YP_690040.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_690041.1	Code: K; COG: COG0583
YP_690042.1	Code: E; COG: COG1280
YP_690043.1	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_690044.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_690045.1	Code: J; COG: COG0566
YP_690046.1	Code: OC; COG: COG0526
YP_690047.1	Code: S; COG: COG3148
YP_690048.1	Code: C; COG: COG1042
YP_690049.1	phospholipid synthesis; catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_690050.1	Code: R; COG: COG5544
YP_690051.1	Code: GEPR; COG: COG0477
YP_690054.1	with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline
YP_690055.1	responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA
YP_690056.1	Code: S; COG: COG1496
YP_690057.1	Code: O; COG: COG0542
YP_690058.1	Code: L; COG: COG3385
YP_690059.1	Code: R; COG: COG1611
YP_690060.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_690061.1	SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function
YP_690062.1	Code: S; COG: COG3098
YP_690063.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_690064.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_690065.1	Code: GEPR; COG: COG0477
YP_690066.1	Code: MR; COG: COG4948
YP_690067.1	Code: MR; COG: COG4948
YP_690068.1	activates OmpR by phophorylation; part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system
YP_690069.1	in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]
YP_690070.1	(p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP
YP_690071.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era
YP_690072.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_690073.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_690074.1	Code: R; COG: COG1512
YP_690075.1	Code: O; COG: COG0602
YP_690079.1	Code: GEPR; COG: COG0477
YP_690080.1	Code: C; COG: COG2086
YP_690081.1	Code: C; COG: COG2025
YP_690082.1	Code: L; COG: COG0582
YP_690083.1	Code: L; COG: COG2801
YP_690084.1	Code: L; COG: COG2963
YP_690092.1	Code: L; COG: COG1484
YP_690093.1	Code: L; COG: COG0305
YP_690098.1	Code: R; COG: COG3772
YP_690100.1	Code: L; COG: COG2801
YP_690101.1	Code: L; COG: COG2963
YP_690103.1	Code: L; COG: COG2801
YP_690104.1	Code: L; COG: COG2963
YP_690106.1	Code: L; COG: COG2801
YP_690107.1	Code: L; COG: COG4220
YP_690108.1	terminase large subunit; Code: R; COG: COG5525
YP_690109.1	Code: R; COG: COG5511
YP_690111.1	Code: OU; COG: COG0616
YP_690118.1	Code: N; COG: COG5492
YP_690121.1	Code: S; COG: COG4672
YP_690123.1	Code: S; COG: COG4723
YP_690124.1	Code: S; COG: COG4733
YP_690125.1	Code: M; COG: COG3637
YP_690128.1	Code: S; COG: COG4886
YP_690129.1	Code: C; COG: COG2440
YP_690130.1	Code: C; COG: COG0644
YP_690131.1	Code: H; COG: COG0720
YP_690132.1	catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity
YP_690133.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_690134.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_690136.1	catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3
YP_690137.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_690138.1	probably a GTPase; may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ
YP_690139.1	converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis
YP_690141.1	forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein
YP_690142.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_690143.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_690144.1	catalyzes the modification of U13 in tRNA(Glu)
YP_690145.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_690146.1	catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins
YP_690147.1	outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus
YP_690148.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses
YP_690149.1	Code: K; COG: COG1846
YP_690150.1	Code: H; COG: COG0163
YP_690151.1	Code: H; COG: COG0043
YP_690153.1	Code: L; COG: COG2801
YP_690154.1	Code: L; COG: COG2801
YP_690156.1	Code: L; COG: COG1662
YP_690157.1	Code: L; COG: COG2963
YP_690158.1	Code: I; COG: COG2084
YP_690159.1	Code: KG; COG: COG1349
YP_690160.1	This protein performs the mismatch recognition step during the DNA repair process
YP_690162.1	Code: KT; COG: COG3604
YP_690163.1	plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309
YP_690164.1	pleiotrophic effects on 3 hydrogenase isozymes; Code: O; COG: COG0409
YP_690165.1	pleiotrophic effects on 3 hydrogenase isozymes; HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase
YP_690166.1	GTP hydrolase involved in nickel liganding into hydrogenases
YP_690167.1	pleiotrophic effects on 3 hydrogenase isozymes; plays a role in hydrogenase nickel cofactor insertion
YP_690168.1	regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon
YP_690169.1	Code: C; COG: COG1142
YP_690170.1	Code: CP; COG: COG0651
YP_690171.1	Code: C; COG: COG0650
YP_690172.1	Code: C; COG: COG3261
YP_690173.1	electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate
YP_690174.1	Code: C; COG: COG3260
YP_690176.1	involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE
YP_690178.1	Code: K; COG: COG5499
YP_690179.1	Code: G; COG: COG2723
YP_690180.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_690181.1	Code: K; COG: COG1609
YP_690182.1	involved in electron transport from formate to hydrogen
YP_690183.1	Code: O; COG: COG0068
YP_690184.1	catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase
YP_690185.1	detoxifies nitric oxide using NADH
YP_690186.1	Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon
YP_690187.1	catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate
YP_690188.1	regulates genes involved in glucitol utilization
YP_690189.1	regulator for glucitol utilization
YP_690190.1	catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate
YP_690191.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_690192.1	Code: G; COG: COG3730
YP_690193.1	membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan
YP_690194.1	Code: R; COG: COG1546
YP_690195.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_690196.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_690197.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_690198.1	controls glycogen synthesis, gluconeogenesis, cell size and surface properties; affects carbohydrate metabolism; has regulatory role in many processes
YP_690199.1	YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent
YP_690200.1	Code: S; COG: COG1238
YP_690201.1	involved in the first step of glutathione biosynthesis
YP_690202.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_690203.1	Code: GEPR; COG: COG0477
YP_690204.1	DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB
YP_690206.1	Code: E; COG: COG1296
YP_690207.1	Code: GEPR; COG: COG0477
YP_690208.1	with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine
YP_690209.1	with ProVX is involved in the high-affinity uptake of glycine betaine
YP_690210.1	for glycine, betaine and proline; with ProWX is involved in the high-affinity uptake of glycine betaine
YP_690211.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_690212.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_690213.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_690214.1	Code: O; COG: COG0695
YP_690215.1	Code: S; COG: COG4575
YP_690218.1	Code: R; COG: COG2916
YP_690219.1	Code: P; COG: COG0607
YP_690220.1	Code: K; COG: COG0640
YP_690221.1	Code: S; COG: COG0401
YP_690222.1	Code: S; COG: COG1652
YP_690223.1	regulator of gab gene expression
YP_690224.1	Code: E; COG: COG1113
YP_690225.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_690226.1	catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate
YP_690227.1	in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution
YP_690229.1	Code: L; COG: COG2801
YP_690230.1	Code: L; COG: COG2963
YP_690231.1	Code: L; COG: COG1662
YP_690233.1	CP4-57 prophage; integrase
YP_690234.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_690235.1	Code: S; COG: COG2914
YP_690236.2	Code: J; COG: COG2913
YP_690237.1	Code: L; COG: COG0497
YP_690238.1	catalyzes the phosphorylation of NAD to NADP
YP_690239.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_690240.1	Code: P; COG: COG4536
YP_690241.1	Code: R; COG: COG4137
YP_690242.1	with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins
YP_690243.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_690244.1	Essential for efficient processing of 16S rRNA
YP_690245.1	tRNA (guanine-7-)-methyltransferase; methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_690246.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_690247.1	Code: M; COG: COG2885
YP_690248.1	Code: T; COG: COG2199
YP_690252.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_690253.1	catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_690254.1	catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_690255.1	associated with 30S ribosomal subunit; interferes with translation elongation
YP_690256.1	Code: L; COG: COG3385
YP_690257.1	Code: E; COG: COG0814
YP_690258.1	Code: E; COG: COG1760
YP_690259.1	has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups
YP_690260.1	Code: C; COG: COG1454
YP_690261.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_690262.1	Code: G; COG: COG0738
YP_690263.1	catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose
YP_690264.1	Code: G; COG: COG4154
YP_690265.1	regulates expression of genes involved in L-fucose utilization
YP_690266.1	Code: R; COG: COG2933
YP_690267.1	Code: S; COG: COG2363
YP_690268.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_690270.1	Code: E; COG: COG0520
YP_690271.1	Code: R; COG: COG2166
YP_690272.1	Code: H; COG: COG1179
YP_690273.1	membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_690274.1	Code: M; COG: COG0860
YP_690275.1	amino acid acetyltransferase; catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis
YP_690276.1	DNA helicase; ssDNA endonuclease; helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_690277.1	DNA helicase; , ssDNA endonuclease; helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_690278.1	Code: O; COG: COG1025
YP_690279.1	DNA helicase; ssDNA endonuclease; catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination
YP_690280.1	Code: NU; COG: COG4967
YP_690282.1	Code: U; COG: COG4795
YP_690283.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_690284.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_690285.1	member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr
YP_690286.1	hydrolyzes diadenosine polyphosphate
YP_690287.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_690288.1	Code: P; COG: COG0861
YP_690290.1	complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH
YP_690291.1	Code: GEPR; COG: COG0477
YP_690292.1	Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
YP_690293.1	controls transcription of galETKM
YP_690294.1	catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding
YP_690295.1	activates the transcription of the lysA gene encoding diaminopimelate decarboxylase
YP_690296.1	Code: M; COG: COG1794
YP_690297.1	Code: GEPR; COG: COG0477
YP_690298.1	catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate
YP_690299.1	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
YP_690300.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_690301.1	Code: L; COG: COG2963
YP_690302.1	Code: L; COG: COG2801
YP_690304.1	Code: M; COG: COG0739
YP_690306.1	Code: L; COG: COG1662
YP_690307.1	molybdenum cofactor-binding protein; participates in purine salvage
YP_690308.1	FAD-binding subunit; with XdhA and XdhC participates in purine salvage
YP_690309.1	iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage
YP_690311.1	Code: L; COG: COG1662
YP_690312.1	Code: F; COG: COG2233
YP_690313.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_690314.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_690315.1	5'-3' single-stranded-DNA-specific exonuclease
YP_690316.1	DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity
YP_690317.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_690318.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic
YP_690320.1	Code: S; COG: COG2938
YP_690321.1	physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator
YP_690322.1	Code: R; COG: COG1272
YP_690323.1	Code: S; COG: COG3097
YP_690324.1	Code: G; COG: COG2723
YP_690325.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_690326.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_690327.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_690328.1	Code: HC; COG: COG0654
YP_690329.1	Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone
YP_690330.1	exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide
YP_690331.1	the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown
YP_690332.1	Code: S; COG: COG3027
YP_690333.2	ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function
YP_690334.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_690335.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_690336.1	specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport
YP_690337.1	MDM; functions in conversion of succinate to propionate
YP_690338.1	functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins
YP_690339.1	catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA
YP_690340.1	Code: C; COG: COG0427
YP_690342.1	Code: S; COG: COG2968
YP_690343.1	Involved in the export of arginine
YP_690344.1	participates in the regulation of osmotic pressure changes within the cel
YP_690345.2	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_690346.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_690347.1	NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate
YP_690348.1	Code: R; COG: COG1661
YP_690352.1	Code: P; COG: COG1122
YP_690353.1	Code: P; COG: COG1118
YP_690354.1	Code: H; COG: COG1072
YP_690355.1	Code: K; COG: COG3722
YP_690356.1	Code: G; COG: COG1494
YP_690357.1	Code: ER; COG: COG1063
YP_690358.1	Code: L; COG: COG1662
YP_690360.1	Code: O; COG: COG0330
YP_690361.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_690362.1	Code: O; COG: COG0501
YP_690363.1	catalyzes the formation of putrescine from agmatine
YP_690365.1	Code: L; COG: COG1662
YP_690367.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_690370.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_690371.1	Code: GEPR; COG: COG0477
YP_690372.1	Code: S; COG: COG3091
YP_690373.1	Code: L; COG: COG2356
YP_690374.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_690375.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_690376.1	Code: K; COG: COG1678
YP_690377.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_690378.1	Code: NU; COG: COG2805
YP_690379.1	Code: R; COG: COG0325
YP_690380.1	Code: S; COG: COG0762
YP_690381.1	Code: S; COG: COG1872
YP_690382.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_690383.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_690386.1	Code: G; COG: COG3090
YP_690387.1	Code: G; COG: COG1593
YP_690389.1	catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis
YP_690391.1	Code: S; COG: COG3171
YP_690392.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_690393.1	Code: L; COG: COG1194
YP_690395.1	Code: CO; COG: COG2924
YP_690396.1	Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_690397.1	Code: GEPR; COG: COG0477
YP_690398.1	Code: E; COG: COG1982
YP_690399.1	Code: R; COG: COG1811
YP_690401.1	Code: L; COG: COG1662
YP_690403.1	Code: C; COG: COG1620
YP_690404.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_690405.1	Code: R; COG: COG3193
YP_690406.1	Code: K; COG: COG2186
YP_690410.1	Code: L; COG: COG1662
YP_690411.1	catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction
YP_690412.1	YghU; B2989; one of eight  glutathione transferases from E. coli
YP_690413.1	Code: O; COG: COG0298
YP_690414.1	may modulate levels of hydrogenease-2; plays a role in hydrogenase nickel cofactor insertion
YP_690416.1	protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC)
YP_690417.1	involved in hydrogen uptake
YP_690418.1	HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits
YP_690419.1	Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2
YP_690420.1	involved in hydrogen uptake
YP_690422.1	Code: Q; COG: COG0412
YP_690423.1	Code: C; COG: COG0667
YP_690424.1	Code: S; COG: COG2862
YP_690425.1	Code: IQR; COG: COG1028
YP_690426.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_690427.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_690428.1	catalyzes the formation of L-homocysteine from cystathionine
YP_690429.1	Code: S; COG: COG0586
YP_690430.1	Code: C; COG: COG1979
YP_690431.1	methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate
YP_690433.1	Code: M; COG: COG4238
YP_690434.1	Code: Q; COG: COG2132
YP_690435.1	Code: I; COG: COG0204
YP_690436.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_690437.1	Code: L; COG: COG3449
YP_690438.1	Code: S; COG: COG3111
YP_690439.1	quorum sensing Escherichia coli regulator B; response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes
YP_690440.1	quorum sensing Escherichia coli regulator C; Code: T; COG: COG0642
YP_690441.1	Code: R; COG: COG2249
YP_690442.1	Code: S; COG: COG1359
YP_690443.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_690444.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_690445.1	Code: R; COG: COG1409
YP_690446.1	Code: S; COG: COG3151
YP_690447.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_690448.1	trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell
YP_690449.1	Code: S; COG: COG5463
YP_690450.1	Code: E; COG: COG0754
YP_690451.1	seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine
YP_690452.1	Code: P; COG: COG0428
YP_690453.1	DHBP synthase; functions during riboflavin biosynthesis
YP_690454.1	Code: S; COG: COG2960
YP_690455.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_690456.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_690458.1	Code: L; COG: COG1662
YP_690459.1	catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose
YP_690460.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_690461.1	Code: S; COG: COG3025
YP_690462.1	Code: T; COG: COG3103
YP_690463.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_690464.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_690465.1	catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin
YP_690466.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_690467.1	activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol
YP_690468.1	Involved in the tartrate degradation pathway
YP_690469.1	Involved in the tartrate degradation pathway
YP_690470.1	Code: P; COG: COG0471
YP_690471.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_690472.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_690473.1	DNA biosynthesis; synthesizes RNA primers at the replication forks
YP_690474.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_690475.1	Code: L; COG: COG3385
YP_690476.1	Code: L; COG: COG3663
YP_690477.1	Code: K; COG: COG1695
YP_690478.1	catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate
YP_690479.1	Code: K; COG: COG1609
YP_690480.1	in Escherichia coli this is the second beta-galactosidase system
YP_690481.1	in Escherichia coli this is the second beta-galactosidase system
YP_690482.1	Code: E; COG: COG0531
YP_690484.1	Code: K; COG: COG5499
YP_690485.1	Code: S; COG: COG4680
YP_690486.1	Code: J; COG: COG2813
YP_690488.1	Code: S; COG: COG2949
YP_690489.1	Code: R; COG: COG0673
YP_690490.1	Code: P; COG: COG0861
YP_690491.1	involved in the import of serine and threonine coupled with the import of sodium
YP_690493.1	Code: G; COG: COG2721
YP_690494.1	catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism
YP_690495.1	Code: GEPR; COG: COG0477
YP_690498.1	Code: L; COG: COG1662
YP_690499.1	regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.
YP_690500.1	Code: S; COG: COG0586
YP_690503.1	Code: S; COG: COG4575
YP_690504.1	Code: S; COG: COG5393
YP_690506.1	Code: S; COG: COG2259
YP_690507.1	Code: O; COG: COG0435
YP_690508.1	Code: S; COG: COG3152
YP_690509.1	Code: K; COG: COG0583
YP_690510.1	Code: R; COG: COG1741
YP_690512.1	Code: S; COG: COG3681
YP_690513.1	Code: E; COG: COG0814
YP_690514.1	Code: E; COG: COG1760
YP_690515.1	Code: J; COG: COG0251
YP_690516.1	Code: C; COG: COG1882
YP_690517.2	catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism
YP_690518.1	involved in the import of threonine and serine in combination with the import of a proton
YP_690519.1	catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic
YP_690520.1	regulates the tdcABCDEFG operon which is involved in amino acid degradation
YP_690521.1	participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon
YP_690525.1	Code: G; COG: COG1929
YP_690526.1	catalyzes the reduction of tartronate semialdehyde to glycerate
YP_690527.1	Code: G; COG: COG3836
YP_690528.1	Code: GEPR; COG: COG0477
YP_690529.1	Code: L; COG: COG1662
YP_690531.1	Code: NU; COG: COG3121
YP_690532.1	Code: L; COG: COG2801
YP_690533.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_690534.1	Code: NU; COG: COG3539
YP_690535.1	Code: R; COG: COG0313
YP_690536.1	Code: R; COG: COG3107
YP_690537.1	Code: L; COG: COG0792
YP_690538.1	Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein
YP_690539.1	Code: R; COG: COG2823
YP_690540.1	Code: R; COG: COG0701
YP_690541.1	Code: MG; COG: COG0702
YP_690542.1	Code: R; COG: COG0693
YP_690543.1	Code: S; COG: COG3787
YP_690544.1	Code: L; COG: COG2827
YP_690545.1	Code: R; COG: COG3153
YP_690546.1	Code: I; COG: COG3154
YP_690547.1	Code: O; COG: COG0826
YP_690548.1	Code: O; COG: COG0826
YP_690549.1	Code: C; COG: COG2141
YP_690550.1	tryptophan transporter of high affinity
YP_690551.1	participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division
YP_690552.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_690553.1	Code: J; COG: COG1185
YP_690554.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_690555.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_690556.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_690557.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_690558.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_690559.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_690560.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_690561.2	Code: U; COG: COG1314
YP_690562.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_690563.1	catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate
YP_690564.1	inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins
YP_690565.1	Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit
YP_690566.1	RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability
YP_690567.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_690568.1	penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_690569.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_690570.1	Code: GER; COG: COG0697
YP_690571.1	involved in the peptidyltransferase reaction during translation
YP_690573.1	Code: H; COG: COG0142
YP_690574.1	activator of maltose metabolism genes
YP_690575.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_690576.1	Code: K; COG: COG5007
YP_690577.1	Code: R; COG: COG3113
YP_690578.1	Code: Q; COG: COG2854
YP_690579.1	Code: Q; COG: COG1463
YP_690580.1	Code: Q; COG: COG0767
YP_690581.1	ATP-binding subunit of a  ABC toluene efflux transporter
YP_690582.1	YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers
YP_690583.1	Code: M; COG: COG0794
YP_690584.1	forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis
YP_690585.1	Code: S; COG: COG3117
YP_690586.1	LptA; periplasmic binding protein part of a  ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system
YP_690587.1	Code: R; COG: COG1137
YP_690588.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen
YP_690589.1	YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing
YP_690590.1	Code: GT; COG: COG1762
YP_690591.1	Code: R; COG: COG1660
YP_690592.1	Code: G; COG: COG1925
YP_690594.1	Code: Q; COG: COG3155
YP_690595.1	sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA
YP_690596.1	Code: R; COG: COG1242
YP_690597.1	catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
YP_690598.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_690599.1	Code: L; COG: COG2963
YP_690600.1	Code: L; COG: COG2801
YP_690601.1	Code: G; COG: COG2731
YP_690602.1	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_690603.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_690604.1	Code: GEPR; COG: COG0477
YP_690605.1	catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid
YP_690606.1	Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization
YP_690608.1	Code: L; COG: COG1662
YP_690609.1	YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic
YP_690610.1	Code: R; COG: COG2969
YP_690611.1	transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation
YP_690612.1	forms a direct contact with the tRNA during translation
YP_690613.2	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_690614.1	Code: R; COG: COG1485
YP_690615.1	Code: S; COG: COG3105
YP_690616.1	Code: O; COG: COG0265
YP_690617.1	Code: O; COG: COG0265
YP_690618.1	oxidizes malate to oxaloacetate
YP_690619.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_690621.1	Code: K; COG: COG2732
YP_690622.1	with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_690623.1	with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_690624.2	membrane protein AaeX; the gene is a member of the aaeXAB operon
YP_690625.1	Code: K; COG: COG0583
YP_690626.1	responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA
YP_690627.1	Code: S; COG: COG3164
YP_690628.1	involved in the processing of the 5'end of 16S rRNA
YP_690629.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_690630.1	part of cell wall structural complex MreBCD; transmembrane component
YP_690631.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_690632.2	functions in MreBCD complex in some organisms
YP_690633.1	regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules
YP_690634.1	Code: CR; COG: COG0604
YP_690635.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_690636.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_690637.1	Code: S; COG: COG3924
YP_690638.1	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_690639.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_690640.1	Code: J; COG: COG0042
YP_690641.1	Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_690642.1	Code: L; COG: COG0863
YP_690643.1	Code: L; COG: COG1662
YP_690645.1	Code: ET; COG: COG0834
YP_690646.1	Code: E; COG: COG0765
YP_690647.1	Code: E; COG: COG1126
YP_690648.1	Code: R; COG: COG0663
YP_690650.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_690651.1	RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA
YP_690652.1	Code: S; COG: COG2922
YP_690653.1	Code: LU; COG: COG0758
YP_690654.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_690655.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_690656.1	catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase
YP_690657.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_690659.1	Code: L; COG: COG3436
YP_690660.1	Code: L; COG: COG3436
YP_690661.1	Code: L; COG: COG4584
YP_690662.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_690663.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_690664.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_690665.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_690666.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_690667.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_690668.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_690669.1	late assembly protein
YP_690670.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_690671.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_690672.1	binds 5S rRNA along with protein L5 and L25
YP_690673.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_690674.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_690675.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_690676.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_690677.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_690678.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_690679.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_690680.1	one of the stabilizing components for the large ribosomal subunit
YP_690681.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_690682.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_690683.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_690684.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_690685.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_690686.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_690687.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_690688.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_690689.1	Code: NOU; COG: COG1989
YP_690690.1	iron storage protein
YP_690691.1	Code: P; COG: COG2906
YP_690692.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_690693.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_690694.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_690695.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_690696.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_690697.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_690698.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_690699.1	Code: S; COG: COG2964
YP_690700.1	rotamase
YP_690701.1	Code: S; COG: COG2900
YP_690702.1	rotamase
YP_690703.1	Code: R; COG: COG3529
YP_690704.1	involved in potassium efflux
YP_690705.1	required for KefB activity
YP_690706.1	Code: R; COG: COG0488
YP_690707.1	Code: R; COG: COG0429
YP_690708.1	Code: S; COG: COG3089
YP_690709.1	Code: C; COG: COG3954
YP_690710.1	Code: O; COG: COG1765
YP_690711.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_690712.1	Code: S; COG: COG1289
YP_690713.1	DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate
YP_690714.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_690715.1	Code: D; COG: COG2184
YP_690717.1	Code: O; COG: COG0652
YP_690718.1	Code: GEPR; COG: COG0477
YP_690719.1	Code: C; COG: COG1251
YP_690720.1	involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations
YP_690721.1	member of the FNT family of formate and nitrite transporters
YP_690722.1	multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin
YP_690724.1	catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine
YP_690725.1	YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine
YP_690726.1	Code: G; COG: COG0524
YP_690727.1	may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes
YP_690731.1	phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE)
YP_690732.1	Code: G; COG: COG1015
YP_690733.1	Code: E; COG: COG3457
YP_690736.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_690737.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_690738.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_690739.1	Code: L; COG: COG0338
YP_690740.1	Code: S; COG: COG3266
YP_690741.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_690742.2	type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_690743.2	outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa
YP_690746.1	Code: NU; COG: COG3166
YP_690748.1	bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits
YP_690749.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_690751.1	Code: R; COG: COG1011
YP_690752.1	Code: J; COG: COG1188
YP_690753.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_690755.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_690756.1	membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR
YP_690757.1	part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation
YP_690758.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_690759.1	Code: K; COG: COG2183
YP_690760.1	Code: P; COG: COG1918
YP_690761.1	cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake
YP_690763.1	Code: S; COG: COG5464
YP_690764.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_690765.1	Code: L; COG: COG2801
YP_690766.1	Code: T; COG: COG2337
YP_690767.1	Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis
YP_690768.1	involved in high-affinity gluconate transport
YP_690769.1	cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_690770.1	Code: GE; COG: COG2610
YP_690771.1	amylomaltase; acts to release glucose from maltodextrins
YP_690772.1	Code: G; COG: COG0058
YP_690773.1	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides
YP_690774.1	catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester
YP_690775.1	Code: S; COG: COG1690
YP_690776.1	Code: KT; COG: COG4650
YP_690777.1	represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism
YP_690778.1	protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity
YP_690779.1	belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine
YP_690780.1	in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane
YP_690782.1	Code: L; COG: COG3385
YP_690784.1	Code: G; COG: COG0058
YP_690785.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_690786.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_690787.1	catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen
YP_690788.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_690789.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_690790.1	YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP)
YP_690791.1	thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate
YP_690792.1	Code: K; COG: COG1609
YP_690793.1	Code: R; COG: COG1741
YP_690794.1	Code: R; COG: COG0673
YP_690795.1	YhhY; regulated by the fur regulator; unknown function
YP_690796.1	periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides
YP_690798.1	hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate
YP_690799.1	with UgpABC is involved in uptake of glycerol-3-phosphate
YP_690800.1	with UgpEC is involved in the uptake of glycerol-3-phosphate
YP_690801.1	with UgpACE is involved in the uptake of glycerol-3-phosphate
YP_690802.1	with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_690803.1	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_690804.1	Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_690805.1	LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter
YP_690806.1	Code: E; COG: COG0683
YP_690808.1	Code: E; COG: COG0683
YP_690809.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_690810.1	ABC transporter, membrane protein
YP_690811.1	ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions
YP_690812.1	catalyzes the methylation of 16S rRNA at position G966
YP_690813.1	Code: S; COG: COG3776
YP_690815.1	Code: S; COG: COG3714
YP_690816.1	P-type ATPase involved in the export of lead, cadmium, zinc and mercury
YP_690817.1	TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs
YP_690818.1	Code: S; COG: COG1738
YP_690820.2	Code: GEPR; COG: COG0477
YP_690821.1	Code: R; COG: COG0628
YP_690822.1	Code: H; COG: COG2091
YP_690823.1	Code: E; COG: COG0747
YP_690824.1	with NikACDE is involved in nickel transport into the cell
YP_690825.1	with NikABDE is involved in nickel transport into the cell
YP_690826.1	with NikABCE is involved in nickel transport into the cell
YP_690827.1	with NikABCD is involved with nickel transport into the cell
YP_690828.1	Inhibits transcription at high concentrations of nickel
YP_690829.1	Code: S; COG: COG4226
YP_690830.1	Code: V; COG: COG0842
YP_690832.1	Code: M; COG: COG0845
YP_690840.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_690841.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_690843.1	Code: NU; COG: COG3121
YP_690845.1	Code: L; COG: COG2963
YP_690846.1	Code: L; COG: COG1662
YP_690848.1	Code: R; COG: COG2081
YP_690849.1	Code: P; COG: COG0306
YP_690850.1	ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_690851.1	Code: T; COG: COG0589
YP_690852.1	predicted SAM-dependent methyltransferase
YP_690853.1	Code: E; COG: COG0339
YP_690854.1	Code: R; COG: COG2961
YP_690855.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_690856.1	regulates the expression of of the arsRBC involved in resistance to arsenic
YP_690857.1	Code: P; COG: COG1055
YP_690858.1	Code: P; COG: COG1393
YP_690860.1	Code: L; COG: COG1662
YP_690861.1	Code: R; COG: COG0701
YP_690863.1	Code: M; COG: COG3065
YP_690864.1	Code: K; COG: COG2771
YP_690866.1	inactive form
YP_690867.1	Code: S; COG: COG3247
YP_690868.1	Code: K; COG: COG2771
YP_690869.1	Code: L; COG: COG1662
YP_690870.1	Code: L; COG: COG2963
YP_690871.1	Code: L; COG: COG2801
YP_690872.1	Code: K; COG: COG1278
YP_690873.1	Code: K; COG: COG2944
YP_690875.1	Code: CHR; COG: COG1052
YP_690876.1	Code: M; COG: COG2885
YP_690877.1	Code: C; COG: COG0243
YP_690878.1	Code: KR; COG: COG0454
YP_690879.2	constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine
YP_690880.1	Code: N; COG: COG5571
YP_690881.1	Code: GEPR; COG: COG0477
YP_690882.1	catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide
YP_690883.1	Code: E; COG: COG0747
YP_690884.1	transports peptides consisting of two or three amino acids
YP_690885.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_690886.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_690887.1	Code: E; COG: COG0814
YP_690890.1	Code: L; COG: COG1662
YP_690892.1	Code: D; COG: COG1192
YP_690893.1	binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
YP_690894.1	catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans
YP_690895.2	HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a  phosphodiesterase from E. coli
YP_690896.1	involved in the transport of C4-dicarboxylates across the membrane
YP_690897.1	Code: R; COG: COG0612
YP_690898.1	Code: G; COG: COG0524
YP_690899.1	in Escherichia coli this protein is involved in flagellar function
YP_690900.1	Code: M; COG: COG2982
YP_690901.1	Code: GEPR; COG: COG0477
YP_690902.1	Code: S; COG: COG1295
YP_690903.1	Code: K; COG: COG0583
YP_690904.1	Code: TK; COG: COG2197
YP_690905.1	Code: L; COG: COG3385
YP_690906.1	cytoplasmic; catalyzes the hydrolysis of trehalose to glucose
YP_690908.1	Code: L; COG: COG1662
YP_690909.1	Code: S; COG: COG3152
YP_690911.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_690912.1	Code: I; COG: COG2134
YP_690913.1	Code: P; COG: COG1613
YP_690914.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_690915.1	member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers
YP_690916.1	repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates
YP_690917.1	response regulator in two-component regulatory system with CpxA; part of the envelope stress response system
YP_690918.1	part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
YP_690919.1	Code: S; COG: COG2258
YP_690920.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_690921.1	Code: L; COG: COG2801
YP_690922.2	transports degraded pectin products into the bacterial cell
YP_690923.1	SodA; manganese binding; only present under aerobic conditions; destroys free radicals
YP_690924.1	Code: K; COG: COG2207
YP_690925.1	activates the expression of the rhaBAD operon and rhaT gene
YP_690926.1	catalyzes the ATP-dependent phosphorylation of rhamnulose
YP_690927.1	catalyzes the formation of L-rhamnulose from L-rhamnose
YP_690928.1	Code: G; COG: COG0235
YP_690929.1	Code: S; COG: COG3254
YP_690930.1	with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system
YP_690931.1	Code: G; COG: COG1299
YP_690932.1	with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars
YP_690934.1	Code: L; COG: COG1662
YP_690935.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_690936.1	Code: C; COG: COG0243
YP_690937.1	Code: C; COG: COG0437
YP_690938.1	cytochrome b556(FDO) component; heme containing
YP_690939.1	required for the formation of active formate dehydrogenase
YP_690945.1	Code: L; COG: COG1662
YP_690946.1	Code: KR; COG: COG0454
YP_690947.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_690948.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_690949.1	Code: R; COG: COG1011
YP_690950.1	Code: KG; COG: COG1349
YP_690951.1	Code: G; COG: COG0524
YP_690952.1	Code: I; COG: COG2084
YP_690953.1	Code: G; COG: COG3684
YP_690954.1	Code: G; COG: COG2942
YP_690955.1	Code: G; COG: COG2017
YP_690956.1	Code: G; COG: COG1501
YP_690957.1	Code: G; COG: COG2211
YP_690958.1	Code: G; COG: COG2211
YP_690960.1	Code: L; COG: COG1662
YP_690961.1	Code: GEPR; COG: COG0477
YP_690963.1	Code: K; COG: COG2188
YP_690964.1	Code: L; COG: COG3385
YP_690965.1	Code: T; COG: COG1217
YP_690966.1	forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme
YP_690967.1	sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation
YP_690968.1	response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54
YP_690969.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_690970.1	Code: S; COG: COG3078
YP_690971.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_690972.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_690973.2	Code: I; COG: COG0204
YP_690974.1	Code: L; COG: COG1662
YP_690975.1	Code: OC; COG: COG0526
YP_690976.1	catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages
YP_690977.1	Code: S; COG: COG3084
YP_690978.1	in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis
YP_690979.1	in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway
YP_690980.1	catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX
YP_690981.1	Code: P; COG: COG0168
YP_690982.1	Code: S; COG: COG1739
YP_690983.1	catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters
YP_690984.1	includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_690985.1	FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_690986.1	NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin
YP_690987.1	catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol
YP_690988.1	Code: K; COG: COG0250
YP_690989.1	magnesium dependent; not involved in the Sec-independent protein export system
YP_690990.1	with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane
YP_690991.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_690992.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_690993.1	an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions
YP_690994.1	Code: S; COG: COG3165
YP_690995.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_690996.1	YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner
YP_690997.1	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_690998.1	Code: Q; COG: COG0412
YP_690999.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_691000.1	Code: K; COG: COG0583
YP_691001.1	Code: GER; COG: COG0697
YP_691002.1	purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium
YP_691003.1	lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates
YP_691004.1	Code: E; COG: COG1280
YP_691005.1	Code: E; COG: COG1280
YP_691006.1	functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway
YP_691007.1	catalyzes the hydrolysis of phosphatidylcholine
YP_691008.1	Code: Q; COG: COG2050
YP_691009.1	Code: R; COG: COG2962
YP_691012.1	responsible for the influx of magnesium ions
YP_691014.1	Code: L; COG: COG3385
YP_691016.1	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_691017.1	YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function
YP_691018.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_691019.1	Code: S; COG: COG3159
YP_691020.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_691021.1	Code: N; COG: COG5567
YP_691025.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_691026.1	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_691027.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_691028.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_691029.1	Code: H; COG: COG2959
YP_691030.1	Code: H; COG: COG3071
YP_691031.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_691032.1	Code: L; COG: COG2801
YP_691033.1	Code: R; COG: COG0641
YP_691034.1	uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function
YP_691035.1	Code: M; COG: COG1922
YP_691036.1	enterobacterial common antigen polymerase
YP_691037.1	catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis
YP_691038.1	Code: R; COG: COG2244
YP_691039.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_691040.1	Code: KR; COG: COG0454
YP_691041.1	Code: M; COG: COG1209
YP_691042.1	Code: M; COG: COG1088
YP_691043.1	catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid
YP_691044.1	Code: M; COG: COG0381
YP_691045.1	Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein
YP_691046.1	Code: M; COG: COG0472
YP_691048.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_691049.1	Code: OC; COG: COG0526
YP_691050.1	enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
YP_691051.1	catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation
YP_691052.1	single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication
YP_691053.1	Code: O; COG: COG0760
YP_691054.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_691055.1	participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_691056.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_691057.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_691058.2	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_691059.1	Code: S; COG: COG3978
YP_691060.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_691061.1	among the AAA+ ATPases, the YifB protease belongs to the Helix 2 insert clade; unknown function
YP_691062.1	Code: S; COG: COG3085
YP_691063.1	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
YP_691064.1	Code: K; COG: COG2186
YP_691065.1	Code: GEPR; COG: COG0477
YP_691066.1	DNA-binding transcriptional repressor of ribose metabolism
YP_691067.1	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_691068.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_691069.1	Code: L; COG: COG1662
YP_691070.1	cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_691071.1	Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH
YP_691072.1	Code: L; COG: COG3385
YP_691073.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_691074.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_691075.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_691076.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_691077.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_691078.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_691079.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_691080.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_691081.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_691082.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_691083.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_691084.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_691085.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_691086.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_691087.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_691088.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_691089.1	contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA
YP_691090.2	interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase
YP_691091.1	Code: L; COG: COG3385
YP_691092.1	Code: NU; COG: COG3539
YP_691093.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_691094.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_691095.1	Code: NU; COG: COG3188
YP_691096.1	Code: NU; COG: COG3539
YP_691097.1	Code: P; COG: COG0226
YP_691098.1	part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_691099.1	Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_691100.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_691101.1	regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon
YP_691102.1	positive regulator of the beta-glucoside operon; transcriptional antiterminator
YP_691103.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_691104.1	Code: G; COG: COG2723
YP_691105.1	Code: G; COG: COG4580
YP_691106.1	Code: P; COG: COG2382
YP_691107.1	Code: G; COG: COG0363
YP_691108.1	Code: S; COG: COG3196
YP_691111.1	Code: L; COG: COG3436
YP_691113.1	might be involved in hypersensitivity to nitrofurzone
YP_691114.1	YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily
YP_691115.1	Code: R; COG: COG2252
YP_691116.1	Code: R; COG: COG0431
YP_691117.1	Code: H; COG: COG2091
YP_691118.1	Code: L; COG: COG2963
YP_691119.1	Code: L; COG: COG2801
YP_691121.1	Confers resistance to chloramphenicol
YP_691122.1	tryptophan transporter of low affinity
YP_691123.1	tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan
YP_691124.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_691125.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_691126.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_691127.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_691128.1	Code: L; COG: COG0593
YP_691129.1	binds the polymerase to DNA and acts as a sliding clamp
YP_691130.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_691131.1	negatively supercoils closed circular double-stranded DNA
YP_691132.1	Code: S; COG: COG3753
YP_691133.1	YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins
YP_691135.1	Code: G; COG: COG3734
YP_691136.1	Code: GEPR; COG: COG0477
YP_691137.1	FAD/NAD(P)-binding domain
YP_691139.1	Code: R; COG: COG5645
YP_691140.1	with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress
YP_691141.1	16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent
YP_691142.1	Code: R; COG: COG2985
YP_691143.1	Code: K; COG: COG2188
YP_691144.1	Code: G; COG: COG1263
YP_691145.1	Code: K; COG: COG2207
YP_691146.1	uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function
YP_691147.1	Code: P; COG: COG3119
YP_691149.1	Code: S; COG: COG2149
YP_691151.1	Code: R; COG: COG0641
YP_691152.1	multidrug efflux protein involved in adaptation to low energy shock
YP_691153.1	Code: EH; COG: COG0028
YP_691154.1	with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit
YP_691155.1	response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter
YP_691156.1	Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph
YP_691157.1	membrane protein regulates uhpT expression
YP_691158.1	cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate
YP_691159.1	catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type
YP_691160.1	Code: R; COG: COG2252
YP_691162.2	experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS
YP_691163.1	Code: L; COG: COG2963
YP_691164.1	Code: L; COG: COG2801
YP_691165.1	Code: P; COG: COG1629
YP_691166.1	Code: Q; COG: COG3486
YP_691167.1	Code: Q; COG: COG4264
YP_691168.1	Code: J; COG: COG1670
YP_691170.1	Code: GEPR; COG: COG0477
YP_691172.1	Code: L; COG: COG1662
YP_691173.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_691174.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_691175.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_691176.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_691177.1	Code: L; COG: COG2963
YP_691178.1	Code: L; COG: COG2801
YP_691180.1	Code: L; COG: COG2963
YP_691185.1	Code: L; COG: COG0582
YP_691186.1	catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides
YP_691188.1	Code: F; COG: COG2233
YP_691189.1	Code: E; COG: COG0786
YP_691190.1	catalyzes branch migration in Holliday junction intermediates
YP_691191.1	specifically modifies tRNA at position G18
YP_691192.1	Code: TK; COG: COG0317
YP_691193.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_691194.1	Essential for recycling GMP and indirectly, cGMP
YP_691196.1	this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+
YP_691197.1	Code: S; COG: COG2860
YP_691199.1	Code: S; COG: COG1561
YP_691200.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_691201.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_691202.1	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_691203.1	catalyzes the formation of dUMP from dUTP
YP_691204.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_691205.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_691206.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_691207.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_691208.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_691209.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_691211.1	Code: L; COG: COG1662
YP_691212.1	Code: M; COG: COG0859
YP_691213.1	Code: M; COG: COG0438
YP_691215.1	Code: M; COG: COG1442
YP_691217.1	Code: M; COG: COG1442
YP_691218.1	Code: M; COG: COG0438
YP_691219.1	Code: M; COG: COG3307
YP_691220.1	Code: M; COG: COG0859
YP_691221.1	catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core
YP_691222.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_691223.1	involved in lipopolysaccharide biosynthesis
YP_691224.1	catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine
YP_691225.1	converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism
YP_691226.1	Code: M; COG: COG0463
YP_691227.1	Code: L; COG: COG1662
YP_691228.1	Code: S; COG: COG2861
YP_691229.2	Code: D; COG: COG4942
YP_691230.2	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_691231.1	Code: L; COG: COG1662
YP_691233.1	Code: P; COG: COG0607
YP_691234.1	Code: O; COG: COG0695
YP_691235.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_691236.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_691237.1	catalyzes the O-acetylation of serine
YP_691238.1	member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates
YP_691239.1	flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration
YP_691240.1	represses the lctPRD operon
YP_691241.1	Code: C; COG: COG1620
YP_691242.1	Code: UW; COG: COG5295
YP_691245.1	Code: L; COG: COG1662
YP_691249.1	Acts as a repressor of the mtlAD operon
YP_691250.1	Code: G; COG: COG0246
YP_691251.1	Code: G; COG: COG2213
YP_691253.1	Code: V; COG: COG1566
YP_691254.1	Code: O; COG: COG0625
YP_691255.1	catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_691256.1	Code: J; COG: COG3276
YP_691257.1	Code: C; COG: COG1454
YP_691258.1	Code: C; COG: COG1012
YP_691261.1	Code: V; COG: COG1566
YP_691264.1	Code: L; COG: COG1662
YP_691265.1	Code: M; COG: COG3713
YP_691266.1	Code: S; COG: COG3533
YP_691267.1	Code: G; COG: COG2211
YP_691268.1	Code: K; COG: COG2207
YP_691269.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_691270.1	L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate
YP_691271.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate
YP_691272.1	Code: G; COG: COG1070
YP_691273.1	Code: G; COG: COG1638
YP_691274.1	Code: G; COG: COG1593
YP_691275.1	Code: G; COG: COG3090
YP_691276.1	Code: L; COG: COG1662
YP_691278.1	NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate
YP_691279.1	Code: K; COG: COG1414
YP_691280.1	Code: C; COG: COG1142
YP_691281.1	transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis
YP_691282.1	periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds
YP_691283.1	Code: R; COG: COG2992
YP_691284.1	with XylFH is part of the high affinity xylose ABC transporter
YP_691285.1	periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity
YP_691286.1	Code: G; COG: COG1070
YP_691287.1	Code: S; COG: COG4682
YP_691288.1	Code: S; COG: COG4682
YP_691289.1	Code: S; COG: COG3274
YP_691291.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_691292.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_691293.1	Code: L; COG: COG1662
YP_691296.1	Code: V; COG: COG0841
YP_691297.1	Code: K; COG: COG2207
YP_691298.1	regulates genes in response to acid and/or during stationary phase
YP_691299.1	Code: E; COG: COG0076
YP_691300.1	Code: P; COG: COG1858
YP_691301.1	Code: L; COG: COG1662
YP_691303.1	Code: S; COG: COG3691
YP_691304.1	with UspC and Usp E is involved in resistance to UV radiation
YP_691305.1	Code: C; COG: COG1018
YP_691306.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_691307.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_691308.1	Code: G; COG: COG0580
YP_691309.1	Code: S; COG: COG3074
YP_691310.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_691311.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_691312.1	heat shock protein involved in degradation of misfolded proteins
YP_691313.1	heat shock protein involved in degradation of misfolded proteins
YP_691314.1	Code: D; COG: COG3087
YP_691315.1	negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins
YP_691316.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_691317.1	member of the NlpC/P60 superfamily of peptidases
YP_691318.1	repressor of all met genes but metF; when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_691319.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_691320.1	multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_691321.1	MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor
YP_691322.1	Code: P; COG: COG0376
YP_691323.1	Code: GER; COG: COG0697
YP_691324.1	Code: S; COG: COG3738
YP_691325.1	FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site
YP_691326.1	FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS
YP_691327.1	involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein
YP_691328.1	Code: O; COG: COG1180
YP_691329.1	FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog
YP_691330.1	Code: K; COG: COG2207
YP_691331.1	Code: R; COG: COG2194
YP_691332.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_691333.1	catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis
YP_691334.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_691335.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_691336.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_691337.1	Code: L; COG: COG3385
YP_691338.1	Code: MR; COG: COG4948
YP_691339.1	Code: L; COG: COG1662
YP_691340.1	activator, hydrogen peroxide-inducible genes; Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA
YP_691341.1	catalyzes the conversion of NADPH to NADH
YP_691342.1	negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis
YP_691344.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_691345.2	involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space
YP_691346.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_691347.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_691348.1	catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon
YP_691349.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_691350.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_691351.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_691352.1	Modulates Rho-dependent transcription termination
YP_691353.1	binds directly to 23S ribosomal RNA
YP_691354.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_691355.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_691356.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_691357.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_691358.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_691359.1	in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center
YP_691360.2	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_691361.1	with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate
YP_691362.1	Code: H; COG: COG0476
YP_691363.1	catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_691364.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_691365.1	binds specifically to the major sigma factor sigma 70; active in stationary phase
YP_691366.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_691367.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_691368.1	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures
YP_691369.1	Code: S; COG: COG3068
YP_691370.1	histone-like DNA-binding protein
YP_691372.1	Code: UNTP; COG: COG3678
YP_691373.1	Code: T; COG: COG0642
YP_691374.1	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein
YP_691375.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_691376.1	involved in de novo purine biosynthesis
YP_691377.1	Code: KR; COG: COG0454
YP_691378.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_691379.1	Code: C; COG: COG2224
YP_691380.1	regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase
YP_691381.1	one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity
YP_691382.1	Code: P; COG: COG1283
YP_691383.1	alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family
YP_691384.1	Code: ER; COG: COG1063
YP_691385.1	Code: G; COG: COG3716
YP_691386.1	Code: G; COG: COG3715
YP_691387.1	Code: G; COG: COG3444
YP_691388.1	Code: G; COG: COG2893
YP_691389.1	Converts D-sorbitol-dphosphate to D-fructose-6-phosphate
YP_691390.1	Code: K; COG: COG2390
YP_691391.1	catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA
YP_691395.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_691396.1	C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration
YP_691397.1	response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration
YP_691398.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters
YP_691399.1	Code: C; COG: COG1951
YP_691400.1	Code: S; COG: COG3647
YP_691401.1	Code: G; COG: COG2211
YP_691402.1	Code: G; COG: COG1486
YP_691403.1	Code: K; COG: COG2207
YP_691404.1	Code: E; COG: COG1982
YP_691405.1	Code: K; COG: COG2207
YP_691406.1	Code: E; COG: COG0531
YP_691407.1	with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division
YP_691408.1	response regulator in two-component regulatory system with BasS
YP_691409.1	Code: T; COG: COG0642
YP_691410.1	Code: GEPR; COG: COG0477
YP_691413.1	Code: P; COG: COG2824
YP_691414.1	Code: S; COG: COG2764
YP_691415.1	Code: P; COG: COG3638
YP_691416.1	Code: P; COG: COG3221
YP_691418.1	Code: L; COG: COG1662
YP_691420.1	with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_691421.1	possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_691422.1	part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family
YP_691423.1	Code: R; COG: COG0790
YP_691424.1	carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system
YP_691425.1	Code: O; COG: COG4235
YP_691426.1	Code: O; COG: COG3088
YP_691427.1	with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552
YP_691428.1	Code: P; COG: COG3301
YP_691429.1	Code: C; COG: COG0437
YP_691430.1	part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia
YP_691431.1	catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552
YP_691432.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_691433.1	Code: S; COG: COG3162
YP_691434.1	member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake
YP_691435.1	Code: L; COG: COG1662
YP_691437.1	Code: P; COG: COG0025
YP_691438.1	Code: R; COG: COG2252
YP_691439.1	Code: K; COG: COG0789
YP_691440.1	regulates genes involved in response to oxidative stress
YP_691441.1	Code: T; COG: COG4943
YP_691443.1	Code: L; COG: COG1662
YP_691444.1	binds to single stranded DNA and PriA helcase facilitate replication restart
YP_691445.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_691446.1	Code: S; COG: COG2315
YP_691447.1	Code: S; COG: COG0432
YP_691448.1	Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity
YP_691449.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_691450.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_691451.1	Code: L; COG: COG0305
YP_691452.1	Code: CR; COG: COG0604
YP_691453.1	coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia
YP_691454.1	Code: J; COG: COG0042
YP_691457.1	Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB
YP_691458.1	unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential
YP_691459.1	Code: V; COG: COG0534
YP_691460.1	Represses a number of genes involved in the response to DNA damage
YP_691461.1	Code: M; COG: COG0818
YP_691462.2	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_691463.1	catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway
YP_691464.1	catalyzes the formation of 4-hydroxybenzoate from chorismate
YP_691465.1	Code: L; COG: COG1662
YP_691468.1	porin involved in the transport of maltose and maltodextrins
YP_691469.1	with malEFG is involved in import of maltose/maltodextrin
YP_691470.1	functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis
YP_691471.1	with MalKGE is involved in maltose transport into the cell
YP_691472.1	with MalKFE is involved in the transport of maltose into the cell
YP_691473.1	Code: S; COG: COG3223
YP_691477.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_691478.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive
YP_691479.1	Code: L; COG: COG3436
YP_691480.1	Code: L; COG: COG3436
YP_691482.1	IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_691483.2	IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_691484.1	in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown
YP_691485.1	Code: S; COG: COG3314
YP_691486.1	Code: S; COG: COG0700
YP_691488.1	Code: K; COG: COG0583
YP_691489.1	inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS
YP_691491.1	regulates the expression of uxuBA
YP_691492.1	Code: G; COG: COG0246
YP_691493.1	catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate
YP_691494.1	Code: GE; COG: COG2610
YP_691496.1	Code: NU; COG: COG3539
YP_691497.1	Code: NU; COG: COG3539
YP_691498.1	Code: NU; COG: COG3188
YP_691499.1	Code: NU; COG: COG3121
YP_691500.1	Code: L; COG: COG1662
YP_691501.1	Code: NU; COG: COG3539
YP_691502.1	inversion of on/off regulator of fimA
YP_691503.1	Code: L; COG: COG0582
YP_691505.1	Code: S; COG: COG3055
YP_691506.1	Code: L; COG: COG2801
YP_691507.1	Code: L; COG: COG1662
YP_691509.1	Code: KG; COG: COG1349
YP_691511.1	Code: L; COG: COG2963
YP_691514.1	Code: L; COG: COG1662
YP_691515.1	Code: L; COG: COG0582
YP_691516.1	Code: R; COG: COG1064
YP_691517.1	Code: R; COG: COG0433
YP_691518.1	Code: R; COG: COG0795
YP_691519.1	Code: R; COG: COG0795
YP_691520.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_691521.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_691522.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_691523.1	Code: S; COG: COG4269
YP_691524.1	Code: KR; COG: COG0454
YP_691525.1	Code: S; COG: COG3076
YP_691526.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.
YP_691528.1	Code: L; COG: COG1662
YP_691530.1	Code: G; COG: COG2731
YP_691531.1	Code: K; COG: COG1309
YP_691532.1	Code: IQR; COG: COG1028
YP_691533.1	Code: J; COG: COG0251
YP_691534.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_691535.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_691536.1	Code: J; COG: COG0251
YP_691537.1	P-type ATPase involved in magnesium influx
YP_691538.1	regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon
YP_691539.1	Code: G; COG: COG0366
YP_691540.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_691541.1	activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions
YP_691542.1	Code: C; COG: COG3783
YP_691543.1	protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
YP_691544.1	Code: S; COG: COG3028
YP_691545.1	Code: M; COG: COG0773
YP_691546.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_691547.1	Code: L; COG: COG3385
YP_691548.1	membrane component of a  sugar ABC transporter system
YP_691549.1	Code: G; COG: COG1172
YP_691550.1	Code: G; COG: COG1129
YP_691551.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_691552.1	Code: S; COG: COG2105
YP_691553.1	Code: S; COG: COG2911
YP_691554.1	Code: M; COG: COG0729
YP_691555.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_691556.1	Code: R; COG: COG1253
YP_691557.1	Code: R; COG: COG3054
YP_691559.1	catalyzes the formation of AMP from adenosine-3',5'-bisphosphate
YP_691560.1	periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate
YP_691561.1	Code: K; COG: COG1733
YP_691562.1	Code: MG; COG: COG0702
YP_691563.1	Code: GER; COG: COG0697
YP_691564.1	Involved in anaerobic NO protection and iron metabolism
YP_691565.1	involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
YP_691566.1	FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_691567.1	Code: M; COG: COG3061
YP_691569.2	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_691570.1	Code: G; COG: COG1082
YP_691571.1	Code: L; COG: COG1662
YP_691572.1	Code: L; COG: COG2801
YP_691573.1	Code: E; COG: COG0531
YP_691575.1	Code: L; COG: COG1662
YP_691576.1	Code: K; COG: COG1309
YP_691577.1	two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_691578.1	copper binding protein required for copper tolerance; involved in resistance toward heavy metals
YP_691579.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_691580.1	catalyzes the formation of fumarate from aspartate
YP_691581.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_691582.1	uncharacterized member of the APC superfamily of amino acid transporters; unknown function
YP_691583.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_691584.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_691588.1	Code: L; COG: COG1662
YP_691589.1	Code: E; COG: COG1509
YP_691590.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_691591.1	Code: S; COG: COG5510
YP_691592.1	Code: P; COG: COG2076
YP_691593.1	lipocalin; globomycin-sensitive outer membrane lipoprotein
YP_691594.1	Code: V; COG: COG1680
YP_691595.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_691596.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_691597.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_691598.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_691599.1	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_691600.1	Code: M; COG: COG3264
YP_691601.1	catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine
YP_691602.1	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_691603.2	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_691604.1	Code: C; COG: COG1600
YP_691606.1	possibly involved in cell wall synthesis
YP_691607.1	Code: M; COG: COG0860
YP_691608.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_691609.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_691610.1	Stimulates the elongation of poly(A) tails
YP_691611.1	involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein
YP_691612.1	with HflC inhibits proteolysis of lambda cII protein by FtsH
YP_691613.1	with HflK inhibits proteolysis of lambda cII protein by FtsH
YP_691614.1	Code: S; COG: COG3242
YP_691615.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_691616.1	negatively regulates the transcription of genes upregulated by nitrosative stress
YP_691617.1	3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs
YP_691618.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_691620.1	Code: L; COG: COG1662
YP_691621.1	Code: S; COG: COG5463
YP_691622.1	catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA
YP_691624.1	in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility
YP_691625.1	YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo
YP_691626.1	negative regulator of ulaG and ulaABCDEF
YP_691627.1	Code: R; COG: COG2220
YP_691628.1	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_691629.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_691630.1	involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_691631.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_691632.1	UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway
YP_691633.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_691635.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_691636.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_691637.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_691638.1	Code: L; COG: COG2963
YP_691639.1	Code: L; COG: COG2801
YP_691640.1	Code: L; COG: COG2801
YP_691641.1	Code: L; COG: COG2963
YP_691642.1	Code: S; COG: COG3586
YP_691643.1	involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response
YP_691644.1	Code: V; COG: COG0732
YP_691645.1	Code: V; COG: COG0286
YP_691646.1	Code: V; COG: COG4096
YP_691648.1	Code: L; COG: COG1662
YP_691650.1	Code: R; COG: COG0523
YP_691651.1	Code: S; COG: COG2879
YP_691652.1	Code: T; COG: COG1966
YP_691653.1	Code: R; COG: COG1853
YP_691654.1	Code: R; COG: COG1234
YP_691655.1	Code: K; COG: COG2207
YP_691656.1	Code: GEPR; COG: COG0477
YP_691657.1	Code: G; COG: COG3836
YP_691658.1	Code: Q; COG: COG3971
YP_691659.1	Code: E; COG: COG3232
YP_691660.1	Code: S; COG: COG3384
YP_691661.1	Code: C; COG: COG1012
YP_691662.1	Code: Q; COG: COG0179
YP_691663.1	Code: K; COG: COG1846
YP_691664.1	Code: NT; COG: COG0840
YP_691665.1	Code: GEPR; COG: COG0477
YP_691666.1	Code: K; COG: COG1802
YP_691667.1	Code: ER; COG: COG1063
YP_691668.2	catalyzes the transfer of phosphoglycerol to the glucan backbone
YP_691670.1	acts to load the DnaB helicase onto the initiation site during DNA replication
YP_691671.1	This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
YP_691672.1	Code: S; COG: COG3610
YP_691673.1	Code: S; COG: COG2966
YP_691675.1	Code: L; COG: COG1662
YP_691676.1	Code: TK; COG: COG2197
YP_691677.1	regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin
YP_691678.1	Code: R; COG: COG4114
YP_691680.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_691681.1	with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_691682.1	alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_691683.1	manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily
YP_691684.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_691685.1	Code: R; COG: COG2823
YP_691686.1	Code: R; COG: COG4667
YP_691687.1	Code: L; COG: COG0084
YP_691688.1	Code: O; COG: COG1180
YP_691690.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_691691.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_691692.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_691693.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_691694.1	Code: K; COG: COG1396
YP_691695.1	Code: R; COG: COG3726
YP_691696.1	catalyzes the formation of serine from O-phosphoserine
YP_691697.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_691698.1	catalyzes the formation of NAD(+) from nicotinamide ribonucleotide
YP_691699.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_691700.1	catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan
YP_691701.1	When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_691702.1	Code: S; COG: COG1986
YP_691703.1	catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate
YP_691704.1	Code: K; COG: COG2207
YP_691705.1	Code: S; COG: COG3045
YP_691706.1	response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation
YP_691707.1	part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation
YP_691708.1	Code: V; COG: COG4452
YP_691709.1	Code: TK; COG: COG0745
YP_691710.1	member of the SPOUT superfamily of methyltransferases