-- dump date 20140620_065413 -- class Genbank::misc_feature -- table misc_feature_note -- id note 373384000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 373384000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 373384000003 putative catalytic residues [active] 373384000004 putative nucleotide binding site [chemical binding]; other site 373384000005 putative aspartate binding site [chemical binding]; other site 373384000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 373384000007 dimer interface [polypeptide binding]; other site 373384000008 putative threonine allosteric regulatory site; other site 373384000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 373384000010 putative threonine allosteric regulatory site; other site 373384000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 373384000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 373384000013 homoserine kinase; Region: thrB; TIGR00191 373384000014 Protein of unknown function; Region: YhfT; pfam10797 373384000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373384000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 373384000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 373384000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384000019 catalytic residue [active] 373384000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 373384000021 hypothetical protein; Validated; Region: PRK02101 373384000022 transaldolase-like protein; Provisional; Region: PTZ00411 373384000023 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 373384000024 active site 373384000025 dimer interface [polypeptide binding]; other site 373384000026 catalytic residue [active] 373384000027 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 373384000028 MPT binding site; other site 373384000029 trimer interface [polypeptide binding]; other site 373384000030 hypothetical protein; Provisional; Region: PRK10659 373384000031 hypothetical protein; Provisional; Region: PRK10236 373384000032 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 373384000033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 373384000034 hypothetical protein; Provisional; Region: PRK10154 373384000035 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 373384000036 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 373384000037 nucleotide binding site [chemical binding]; other site 373384000038 NEF interaction site [polypeptide binding]; other site 373384000039 SBD interface [polypeptide binding]; other site 373384000040 chaperone protein DnaJ; Provisional; Region: PRK10767 373384000041 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373384000042 HSP70 interaction site [polypeptide binding]; other site 373384000043 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 373384000044 substrate binding site [polypeptide binding]; other site 373384000045 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 373384000046 Zn binding sites [ion binding]; other site 373384000047 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 373384000048 dimer interface [polypeptide binding]; other site 373384000049 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 373384000050 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 373384000051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384000052 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 373384000053 putative dimerization interface [polypeptide binding]; other site 373384000054 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384000055 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 373384000056 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 373384000057 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 373384000058 active site 373384000059 Riboflavin kinase; Region: Flavokinase; smart00904 373384000060 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 373384000061 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 373384000062 HIGH motif; other site 373384000063 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 373384000064 active site 373384000065 KMSKS motif; other site 373384000066 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 373384000067 tRNA binding surface [nucleotide binding]; other site 373384000068 anticodon binding site; other site 373384000069 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 373384000070 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 373384000071 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 373384000072 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373384000073 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 373384000074 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 373384000075 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 373384000076 active site 373384000077 tetramer interface [polypeptide binding]; other site 373384000078 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 373384000079 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 373384000080 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 373384000081 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 373384000082 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 373384000083 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 373384000084 catalytic site [active] 373384000085 subunit interface [polypeptide binding]; other site 373384000086 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 373384000087 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373384000088 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 373384000089 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 373384000090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373384000091 ATP-grasp domain; Region: ATP-grasp_4; cl17255 373384000092 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 373384000093 IMP binding site; other site 373384000094 dimer interface [polypeptide binding]; other site 373384000095 interdomain contacts; other site 373384000096 partial ornithine binding site; other site 373384000097 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 373384000098 carnitine operon protein CaiE; Provisional; Region: PRK13627 373384000099 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 373384000100 putative trimer interface [polypeptide binding]; other site 373384000101 putative metal binding site [ion binding]; other site 373384000102 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 373384000103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 373384000104 substrate binding site [chemical binding]; other site 373384000105 oxyanion hole (OAH) forming residues; other site 373384000106 trimer interface [polypeptide binding]; other site 373384000107 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 373384000108 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 373384000109 acyl-activating enzyme (AAE) consensus motif; other site 373384000110 putative active site [active] 373384000111 putative AMP binding site [chemical binding]; other site 373384000112 putative CoA binding site [chemical binding]; other site 373384000113 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 373384000114 CoA-transferase family III; Region: CoA_transf_3; pfam02515 373384000115 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 373384000116 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 373384000117 active site 373384000118 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 373384000119 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 373384000120 Ligand binding site [chemical binding]; other site 373384000121 Electron transfer flavoprotein domain; Region: ETF; pfam01012 373384000122 putative oxidoreductase FixC; Provisional; Region: PRK10157 373384000123 ferredoxin-like protein FixX; Provisional; Region: PRK15449 373384000124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384000125 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 373384000126 putative substrate translocation pore; other site 373384000127 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 373384000128 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 373384000129 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 373384000130 TrkA-N domain; Region: TrkA_N; pfam02254 373384000131 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 373384000132 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 373384000133 folate binding site [chemical binding]; other site 373384000134 NADP+ binding site [chemical binding]; other site 373384000135 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 373384000136 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 373384000137 active site 373384000138 metal binding site [ion binding]; metal-binding site 373384000139 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 373384000140 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 373384000141 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 373384000142 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 373384000143 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 373384000144 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 373384000145 SurA N-terminal domain; Region: SurA_N; pfam09312 373384000146 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 373384000147 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 373384000148 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 373384000149 OstA-like protein; Region: OstA; pfam03968 373384000150 Organic solvent tolerance protein; Region: OstA_C; pfam04453 373384000151 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 373384000152 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 373384000153 putative metal binding site [ion binding]; other site 373384000154 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373384000155 HSP70 interaction site [polypeptide binding]; other site 373384000156 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 373384000157 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 373384000158 active site 373384000159 ATP-dependent helicase HepA; Validated; Region: PRK04914 373384000160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384000161 ATP binding site [chemical binding]; other site 373384000162 putative Mg++ binding site [ion binding]; other site 373384000163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384000164 nucleotide binding region [chemical binding]; other site 373384000165 ATP-binding site [chemical binding]; other site 373384000166 DNA polymerase II; Reviewed; Region: PRK05762 373384000167 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 373384000168 active site 373384000169 catalytic site [active] 373384000170 substrate binding site [chemical binding]; other site 373384000171 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 373384000172 active site 373384000173 metal-binding site 373384000174 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 373384000175 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 373384000176 intersubunit interface [polypeptide binding]; other site 373384000177 active site 373384000178 Zn2+ binding site [ion binding]; other site 373384000179 L-arabinose isomerase; Provisional; Region: PRK02929 373384000180 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 373384000181 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 373384000182 trimer interface [polypeptide binding]; other site 373384000183 putative substrate binding site [chemical binding]; other site 373384000184 putative metal binding site [ion binding]; other site 373384000185 ribulokinase; Provisional; Region: PRK04123 373384000186 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 373384000187 N- and C-terminal domain interface [polypeptide binding]; other site 373384000188 active site 373384000189 MgATP binding site [chemical binding]; other site 373384000190 catalytic site [active] 373384000191 metal binding site [ion binding]; metal-binding site 373384000192 carbohydrate binding site [chemical binding]; other site 373384000193 homodimer interface [polypeptide binding]; other site 373384000194 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 373384000195 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 373384000196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384000197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384000198 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 373384000199 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373384000200 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 373384000201 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 373384000202 Walker A/P-loop; other site 373384000203 ATP binding site [chemical binding]; other site 373384000204 Q-loop/lid; other site 373384000205 ABC transporter signature motif; other site 373384000206 Walker B; other site 373384000207 D-loop; other site 373384000208 H-loop/switch region; other site 373384000209 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 373384000210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384000211 dimer interface [polypeptide binding]; other site 373384000212 conserved gate region; other site 373384000213 putative PBP binding loops; other site 373384000214 ABC-ATPase subunit interface; other site 373384000215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384000216 dimer interface [polypeptide binding]; other site 373384000217 conserved gate region; other site 373384000218 putative PBP binding loops; other site 373384000219 ABC-ATPase subunit interface; other site 373384000220 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 373384000221 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 373384000222 transcriptional regulator SgrR; Provisional; Region: PRK13626 373384000223 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 373384000224 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 373384000225 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 373384000226 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 373384000227 substrate binding site [chemical binding]; other site 373384000228 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 373384000229 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 373384000230 substrate binding site [chemical binding]; other site 373384000231 ligand binding site [chemical binding]; other site 373384000232 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 373384000233 tartrate dehydrogenase; Region: TTC; TIGR02089 373384000234 2-isopropylmalate synthase; Validated; Region: PRK00915 373384000235 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 373384000236 active site 373384000237 catalytic residues [active] 373384000238 metal binding site [ion binding]; metal-binding site 373384000239 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 373384000240 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 373384000241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384000242 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 373384000243 putative substrate binding pocket [chemical binding]; other site 373384000244 putative dimerization interface [polypeptide binding]; other site 373384000245 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 373384000246 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373384000247 PYR/PP interface [polypeptide binding]; other site 373384000248 dimer interface [polypeptide binding]; other site 373384000249 TPP binding site [chemical binding]; other site 373384000250 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373384000251 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 373384000252 TPP-binding site [chemical binding]; other site 373384000253 dimer interface [polypeptide binding]; other site 373384000254 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 373384000255 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 373384000256 putative valine binding site [chemical binding]; other site 373384000257 dimer interface [polypeptide binding]; other site 373384000258 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 373384000259 similar to fruR leader peptide 373384000260 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 373384000261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384000262 DNA binding site [nucleotide binding] 373384000263 domain linker motif; other site 373384000264 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 373384000265 dimerization interface [polypeptide binding]; other site 373384000266 ligand binding site [chemical binding]; other site 373384000267 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384000268 mraZ protein; Region: TIGR00242 373384000269 MraZ protein; Region: MraZ; pfam02381 373384000270 MraZ protein; Region: MraZ; pfam02381 373384000271 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 373384000272 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 373384000273 cell division protein FtsL; Provisional; Region: PRK10772 373384000274 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 373384000275 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 373384000276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 373384000277 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 373384000278 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373384000279 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373384000280 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373384000281 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 373384000282 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373384000283 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373384000284 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373384000285 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 373384000286 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 373384000287 Mg++ binding site [ion binding]; other site 373384000288 putative catalytic motif [active] 373384000289 putative substrate binding site [chemical binding]; other site 373384000290 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 373384000291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373384000292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373384000293 cell division protein FtsW; Provisional; Region: PRK10774 373384000294 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 373384000295 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 373384000296 active site 373384000297 homodimer interface [polypeptide binding]; other site 373384000298 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 373384000299 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373384000300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373384000301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373384000302 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 373384000303 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 373384000304 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 373384000305 cell division protein FtsQ; Provisional; Region: PRK10775 373384000306 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 373384000307 Cell division protein FtsQ; Region: FtsQ; pfam03799 373384000308 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 373384000309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373384000310 Cell division protein FtsA; Region: FtsA; pfam14450 373384000311 cell division protein FtsZ; Validated; Region: PRK09330 373384000312 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 373384000313 nucleotide binding site [chemical binding]; other site 373384000314 SulA interaction site; other site 373384000315 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 373384000316 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 373384000317 SecA regulator SecM; Provisional; Region: PRK02943 373384000318 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 373384000319 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 373384000320 SEC-C motif; Region: SEC-C; pfam02810 373384000321 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 373384000322 active site 373384000323 8-oxo-dGMP binding site [chemical binding]; other site 373384000324 nudix motif; other site 373384000325 metal binding site [ion binding]; metal-binding site 373384000326 DNA gyrase inhibitor; Reviewed; Region: PRK00418 373384000327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 373384000328 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 373384000329 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 373384000330 CoA-binding site [chemical binding]; other site 373384000331 ATP-binding [chemical binding]; other site 373384000332 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 373384000333 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 373384000334 active site 373384000335 type IV pilin biogenesis protein; Provisional; Region: PRK10573 373384000336 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 373384000337 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 373384000338 putative major pilin subunit; Provisional; Region: PRK10574 373384000339 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 373384000340 Pilin (bacterial filament); Region: Pilin; pfam00114 373384000341 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 373384000342 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 373384000343 dimerization interface [polypeptide binding]; other site 373384000344 active site 373384000345 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 373384000346 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 373384000347 amidase catalytic site [active] 373384000348 Zn binding residues [ion binding]; other site 373384000349 substrate binding site [chemical binding]; other site 373384000350 regulatory protein AmpE; Provisional; Region: PRK10987 373384000351 aromatic amino acid transporter; Provisional; Region: PRK10238 373384000352 Transcriptional regulators [Transcription]; Region: FadR; COG2186 373384000353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384000354 DNA-binding site [nucleotide binding]; DNA binding site 373384000355 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 373384000356 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 373384000357 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 373384000358 dimer interface [polypeptide binding]; other site 373384000359 TPP-binding site [chemical binding]; other site 373384000360 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 373384000361 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373384000362 E3 interaction surface; other site 373384000363 lipoyl attachment site [posttranslational modification]; other site 373384000364 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373384000365 E3 interaction surface; other site 373384000366 lipoyl attachment site [posttranslational modification]; other site 373384000367 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373384000368 E3 interaction surface; other site 373384000369 lipoyl attachment site [posttranslational modification]; other site 373384000370 e3 binding domain; Region: E3_binding; pfam02817 373384000371 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 373384000372 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 373384000373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373384000374 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384000375 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373384000376 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 373384000377 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 373384000378 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 373384000379 substrate binding site [chemical binding]; other site 373384000380 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 373384000381 substrate binding site [chemical binding]; other site 373384000382 ligand binding site [chemical binding]; other site 373384000383 hypothetical protein; Provisional; Region: PRK05248 373384000384 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 373384000385 spermidine synthase; Provisional; Region: PRK00811 373384000386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384000387 S-adenosylmethionine binding site [chemical binding]; other site 373384000388 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 373384000389 multicopper oxidase; Provisional; Region: PRK10965 373384000390 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 373384000391 Multicopper oxidase; Region: Cu-oxidase; pfam00394 373384000392 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 373384000393 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 373384000394 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 373384000395 Trp docking motif [polypeptide binding]; other site 373384000396 putative active site [active] 373384000397 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 373384000398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384000399 active site 373384000400 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 373384000401 active site clefts [active] 373384000402 zinc binding site [ion binding]; other site 373384000403 dimer interface [polypeptide binding]; other site 373384000404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373384000405 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373384000406 Walker A/P-loop; other site 373384000407 ATP binding site [chemical binding]; other site 373384000408 Q-loop/lid; other site 373384000409 ABC transporter signature motif; other site 373384000410 Walker B; other site 373384000411 D-loop; other site 373384000412 H-loop/switch region; other site 373384000413 inner membrane transport permease; Provisional; Region: PRK15066 373384000414 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 373384000415 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 373384000416 putative active site [active] 373384000417 putative metal binding site [ion binding]; other site 373384000418 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 373384000419 tetramerization interface [polypeptide binding]; other site 373384000420 active site 373384000421 Uncharacterized conserved protein [Function unknown]; Region: COG5464 373384000422 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 373384000423 pantoate--beta-alanine ligase; Region: panC; TIGR00018 373384000424 Pantoate-beta-alanine ligase; Region: PanC; cd00560 373384000425 active site 373384000426 ATP-binding site [chemical binding]; other site 373384000427 pantoate-binding site; other site 373384000428 HXXH motif; other site 373384000429 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 373384000430 oligomerization interface [polypeptide binding]; other site 373384000431 active site 373384000432 metal binding site [ion binding]; metal-binding site 373384000433 Fimbrial protein; Region: Fimbrial; cl01416 373384000434 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384000435 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 373384000436 catalytic center binding site [active] 373384000437 ATP binding site [chemical binding]; other site 373384000438 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 373384000439 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 373384000440 active site 373384000441 NTP binding site [chemical binding]; other site 373384000442 metal binding triad [ion binding]; metal-binding site 373384000443 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 373384000444 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 373384000445 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 373384000446 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 373384000447 active site 373384000448 nucleotide binding site [chemical binding]; other site 373384000449 HIGH motif; other site 373384000450 KMSKS motif; other site 373384000451 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 373384000452 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 373384000453 2'-5' RNA ligase; Provisional; Region: PRK15124 373384000454 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 373384000455 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 373384000456 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 373384000457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384000458 ATP binding site [chemical binding]; other site 373384000459 putative Mg++ binding site [ion binding]; other site 373384000460 nucleotide binding region [chemical binding]; other site 373384000461 helicase superfamily c-terminal domain; Region: HELICc; smart00490 373384000462 ATP-binding site [chemical binding]; other site 373384000463 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 373384000464 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 373384000465 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 373384000466 Transglycosylase; Region: Transgly; pfam00912 373384000467 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 373384000468 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 373384000469 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373384000470 N-terminal plug; other site 373384000471 ligand-binding site [chemical binding]; other site 373384000472 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 373384000473 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 373384000474 Walker A/P-loop; other site 373384000475 ATP binding site [chemical binding]; other site 373384000476 Q-loop/lid; other site 373384000477 ABC transporter signature motif; other site 373384000478 Walker B; other site 373384000479 D-loop; other site 373384000480 H-loop/switch region; other site 373384000481 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 373384000482 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 373384000483 siderophore binding site; other site 373384000484 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 373384000485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384000486 ABC-ATPase subunit interface; other site 373384000487 dimer interface [polypeptide binding]; other site 373384000488 putative PBP binding regions; other site 373384000489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384000490 ABC-ATPase subunit interface; other site 373384000491 dimer interface [polypeptide binding]; other site 373384000492 putative PBP binding regions; other site 373384000493 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 373384000494 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373384000495 inhibitor-cofactor binding pocket; inhibition site 373384000496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384000497 catalytic residue [active] 373384000498 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 373384000499 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 373384000500 Cl- selectivity filter; other site 373384000501 Cl- binding residues [ion binding]; other site 373384000502 pore gating glutamate residue; other site 373384000503 dimer interface [polypeptide binding]; other site 373384000504 H+/Cl- coupling transport residue; other site 373384000505 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 373384000506 hypothetical protein; Provisional; Region: PRK10578 373384000507 UPF0126 domain; Region: UPF0126; pfam03458 373384000508 UPF0126 domain; Region: UPF0126; pfam03458 373384000509 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 373384000510 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 373384000511 cobalamin binding residues [chemical binding]; other site 373384000512 putative BtuC binding residues; other site 373384000513 dimer interface [polypeptide binding]; other site 373384000514 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 373384000515 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 373384000516 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 373384000517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373384000518 Zn2+ binding site [ion binding]; other site 373384000519 Mg2+ binding site [ion binding]; other site 373384000520 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 373384000521 serine endoprotease; Provisional; Region: PRK10942 373384000522 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373384000523 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373384000524 protein binding site [polypeptide binding]; other site 373384000525 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373384000526 hypothetical protein; Provisional; Region: PRK13677 373384000527 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 373384000528 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 373384000529 trimer interface [polypeptide binding]; other site 373384000530 active site 373384000531 substrate binding site [chemical binding]; other site 373384000532 CoA binding site [chemical binding]; other site 373384000533 PII uridylyl-transferase; Provisional; Region: PRK05007 373384000534 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 373384000535 metal binding triad; other site 373384000536 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 373384000537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373384000538 Zn2+ binding site [ion binding]; other site 373384000539 Mg2+ binding site [ion binding]; other site 373384000540 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 373384000541 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 373384000542 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 373384000543 active site 373384000544 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 373384000545 rRNA interaction site [nucleotide binding]; other site 373384000546 S8 interaction site; other site 373384000547 putative laminin-1 binding site; other site 373384000548 elongation factor Ts; Provisional; Region: tsf; PRK09377 373384000549 UBA/TS-N domain; Region: UBA; pfam00627 373384000550 Elongation factor TS; Region: EF_TS; pfam00889 373384000551 Elongation factor TS; Region: EF_TS; pfam00889 373384000552 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 373384000553 putative nucleotide binding site [chemical binding]; other site 373384000554 uridine monophosphate binding site [chemical binding]; other site 373384000555 homohexameric interface [polypeptide binding]; other site 373384000556 ribosome recycling factor; Reviewed; Region: frr; PRK00083 373384000557 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 373384000558 hinge region; other site 373384000559 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 373384000560 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 373384000561 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 373384000562 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 373384000563 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 373384000564 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 373384000565 catalytic residue [active] 373384000566 putative FPP diphosphate binding site; other site 373384000567 putative FPP binding hydrophobic cleft; other site 373384000568 dimer interface [polypeptide binding]; other site 373384000569 putative IPP diphosphate binding site; other site 373384000570 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 373384000571 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 373384000572 zinc metallopeptidase RseP; Provisional; Region: PRK10779 373384000573 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 373384000574 active site 373384000575 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 373384000576 protein binding site [polypeptide binding]; other site 373384000577 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 373384000578 putative substrate binding region [chemical binding]; other site 373384000579 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 373384000580 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373384000581 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373384000582 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373384000583 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373384000584 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373384000585 Surface antigen; Region: Bac_surface_Ag; pfam01103 373384000586 periplasmic chaperone; Provisional; Region: PRK10780 373384000587 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 373384000588 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 373384000589 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 373384000590 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 373384000591 trimer interface [polypeptide binding]; other site 373384000592 active site 373384000593 UDP-GlcNAc binding site [chemical binding]; other site 373384000594 lipid binding site [chemical binding]; lipid-binding site 373384000595 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 373384000596 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 373384000597 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 373384000598 active site 373384000599 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 373384000600 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 373384000601 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 373384000602 RNA/DNA hybrid binding site [nucleotide binding]; other site 373384000603 active site 373384000604 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 373384000605 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 373384000606 putative active site [active] 373384000607 putative PHP Thumb interface [polypeptide binding]; other site 373384000608 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 373384000609 generic binding surface II; other site 373384000610 generic binding surface I; other site 373384000611 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 373384000612 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 373384000613 lysine decarboxylase LdcC; Provisional; Region: PRK15399 373384000614 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 373384000615 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 373384000616 homodimer interface [polypeptide binding]; other site 373384000617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384000618 catalytic residue [active] 373384000619 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 373384000620 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 373384000621 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373384000622 putative metal binding site [ion binding]; other site 373384000623 Rho-binding antiterminator; Provisional; Region: PRK11625 373384000624 hypothetical protein; Provisional; Region: PRK04964 373384000625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 373384000626 hypothetical protein; Provisional; Region: PRK09256 373384000627 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 373384000628 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 373384000629 NlpE N-terminal domain; Region: NlpE; pfam04170 373384000630 hypothetical protein; Provisional; Region: PRK11479 373384000631 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 373384000632 prolyl-tRNA synthetase; Provisional; Region: PRK09194 373384000633 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 373384000634 dimer interface [polypeptide binding]; other site 373384000635 motif 1; other site 373384000636 active site 373384000637 motif 2; other site 373384000638 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 373384000639 putative deacylase active site [active] 373384000640 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 373384000641 active site 373384000642 motif 3; other site 373384000643 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 373384000644 anticodon binding site; other site 373384000645 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 373384000646 homodimer interaction site [polypeptide binding]; other site 373384000647 cofactor binding site; other site 373384000648 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 373384000649 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 373384000650 lipoprotein, YaeC family; Region: TIGR00363 373384000651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384000652 dimer interface [polypeptide binding]; other site 373384000653 conserved gate region; other site 373384000654 ABC-ATPase subunit interface; other site 373384000655 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 373384000656 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 373384000657 Walker A/P-loop; other site 373384000658 ATP binding site [chemical binding]; other site 373384000659 Q-loop/lid; other site 373384000660 ABC transporter signature motif; other site 373384000661 Walker B; other site 373384000662 D-loop; other site 373384000663 H-loop/switch region; other site 373384000664 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 373384000665 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 373384000666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384000667 active site 373384000668 motif I; other site 373384000669 motif II; other site 373384000670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384000671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384000672 active site 373384000673 catalytic tetrad [active] 373384000674 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384000675 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384000676 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384000677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373384000678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384000679 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 373384000680 putative effector binding pocket; other site 373384000681 dimerization interface [polypeptide binding]; other site 373384000682 hypothetical protein; Provisional; Region: PRK05421 373384000683 putative catalytic site [active] 373384000684 putative metal binding site [ion binding]; other site 373384000685 putative phosphate binding site [ion binding]; other site 373384000686 putative catalytic site [active] 373384000687 putative phosphate binding site [ion binding]; other site 373384000688 putative metal binding site [ion binding]; other site 373384000689 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373384000690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384000691 S-adenosylmethionine binding site [chemical binding]; other site 373384000692 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 373384000693 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373384000694 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373384000695 catalytic residue [active] 373384000696 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384000697 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384000698 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 373384000699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384000700 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 373384000701 RNA/DNA hybrid binding site [nucleotide binding]; other site 373384000702 active site 373384000703 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 373384000704 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 373384000705 active site 373384000706 catalytic site [active] 373384000707 substrate binding site [chemical binding]; other site 373384000708 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 373384000709 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 373384000710 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 373384000711 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 373384000712 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 373384000713 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 373384000714 ImpE protein; Region: ImpE; pfam07024 373384000715 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384000716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384000717 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384000718 HTH-like domain; Region: HTH_21; pfam13276 373384000719 Integrase core domain; Region: rve; pfam00665 373384000720 Integrase core domain; Region: rve_3; pfam13683 373384000721 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 373384000722 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 373384000723 catalytic residues [active] 373384000724 Lysis protein S; Region: Lysis_S; pfam04971 373384000725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384000726 Transposase; Region: HTH_Tnp_1; pfam01527 373384000727 Integrase core domain; Region: rve; pfam00665 373384000728 Integrase core domain; Region: rve_3; pfam13683 373384000729 Terminase-like family; Region: Terminase_6; pfam03237 373384000730 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 373384000731 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 373384000732 coat protein; Region: PHA01511 373384000733 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 373384000734 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 373384000735 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 373384000736 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 373384000737 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 373384000738 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 373384000739 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 373384000740 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373384000741 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373384000742 catalytic residue [active] 373384000743 Transposase; Region: HTH_Tnp_1; cl17663 373384000744 putative transposase OrfB; Reviewed; Region: PHA02517 373384000745 HTH-like domain; Region: HTH_21; pfam13276 373384000746 Integrase core domain; Region: rve; pfam00665 373384000747 Integrase core domain; Region: rve_3; pfam13683 373384000748 HTH-like domain; Region: HTH_21; pfam13276 373384000749 Integrase core domain; Region: rve; pfam00665 373384000750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384000751 Transposase; Region: HTH_Tnp_1; pfam01527 373384000752 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 373384000753 Phage-related protein [Function unknown]; Region: COG4695 373384000754 Phage portal protein; Region: Phage_portal; pfam04860 373384000755 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 373384000756 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 373384000757 Phage capsid family; Region: Phage_capsid; pfam05065 373384000758 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 373384000759 oligomerization interface [polypeptide binding]; other site 373384000760 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 373384000761 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 373384000762 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 373384000763 Phage tail tube protein; Region: Tail_tube; pfam10618 373384000764 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 373384000765 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 373384000766 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 373384000767 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 373384000768 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 373384000769 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 373384000770 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 373384000771 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 373384000772 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 373384000773 Phage protein GP46; Region: GP46; pfam07409 373384000774 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 373384000775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 373384000776 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 373384000777 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 373384000778 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 373384000779 Ligand binding site; other site 373384000780 Putative Catalytic site; other site 373384000781 DXD motif; other site 373384000782 Predicted membrane protein [Function unknown]; Region: COG2246 373384000783 GtrA-like protein; Region: GtrA; pfam04138 373384000784 integrase; Provisional; Region: int; PHA02601 373384000785 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 373384000786 Int/Topo IB signature motif; other site 373384000787 Protein of unknown function (DUF551); Region: DUF551; pfam04448 373384000788 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 373384000789 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 373384000790 RecT family; Region: RecT; pfam03837 373384000791 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384000792 36-mer N-terminal peptide of the N protein (N36); Region: N36; pfam11438 373384000793 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 373384000794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384000795 non-specific DNA binding site [nucleotide binding]; other site 373384000796 salt bridge; other site 373384000797 sequence-specific DNA binding site [nucleotide binding]; other site 373384000798 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 373384000799 Catalytic site [active] 373384000800 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384000801 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384000802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384000803 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 373384000804 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 373384000805 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 373384000806 Walker A motif; other site 373384000807 ATP binding site [chemical binding]; other site 373384000808 Walker B motif; other site 373384000809 NinF protein; Region: NinF; pfam05810 373384000810 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 373384000811 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 373384000812 Endodeoxyribonuclease RusA; Region: RusA; cl01885 373384000813 Antitermination protein; Region: Antiterm; pfam03589 373384000814 Antitermination protein; Region: Antiterm; pfam03589 373384000815 phage holin, lambda family; Region: holin_lambda; TIGR01594 373384000816 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 373384000817 catalytic residue [active] 373384000818 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 373384000819 KilA-N domain; Region: KilA-N; pfam04383 373384000820 ORF11CD3 domain; Region: ORF11CD3; pfam10549 373384000821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384000822 Transposase; Region: HTH_Tnp_1; pfam01527 373384000823 HTH-like domain; Region: HTH_21; pfam13276 373384000824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384000825 Integrase core domain; Region: rve; pfam00665 373384000826 Integrase core domain; Region: rve_3; pfam13683 373384000827 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 373384000828 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 373384000829 putative catalytic cysteine [active] 373384000830 gamma-glutamyl kinase; Provisional; Region: PRK05429 373384000831 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 373384000832 nucleotide binding site [chemical binding]; other site 373384000833 homotetrameric interface [polypeptide binding]; other site 373384000834 putative phosphate binding site [ion binding]; other site 373384000835 putative allosteric binding site; other site 373384000836 PUA domain; Region: PUA; pfam01472 373384000837 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384000838 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 373384000839 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 373384000840 trimer interface [polypeptide binding]; other site 373384000841 eyelet of channel; other site 373384000842 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 373384000843 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 373384000844 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384000845 active site 373384000846 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 373384000847 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 373384000848 metal binding site [ion binding]; metal-binding site 373384000849 dimer interface [polypeptide binding]; other site 373384000850 hypothetical protein; Reviewed; Region: PRK09588 373384000851 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 373384000852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373384000853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384000854 Coenzyme A binding pocket [chemical binding]; other site 373384000855 putative toxin YafO; Provisional; Region: PRK09885 373384000856 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 373384000857 DNA polymerase IV; Validated; Region: PRK02406 373384000858 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 373384000859 DNA binding site [nucleotide binding] 373384000860 active site 373384000861 hypothetical protein; Validated; Region: PRK06778 373384000862 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373384000863 ligand binding site [chemical binding]; other site 373384000864 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 373384000865 FHIPEP family; Region: FHIPEP; pfam00771 373384000866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 373384000867 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 373384000868 NlpC/P60 family; Region: NLPC_P60; pfam00877 373384000869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 373384000870 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373384000871 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 373384000872 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 373384000873 putative active site [active] 373384000874 putative dimer interface [polypeptide binding]; other site 373384000875 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 373384000876 dimer interface [polypeptide binding]; other site 373384000877 active site 373384000878 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 373384000879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 373384000880 active site 373384000881 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 373384000882 C-lysozyme inhibitor; Provisional; Region: PRK09993 373384000883 C-N hydrolase family amidase; Provisional; Region: PRK10438 373384000884 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 373384000885 putative active site [active] 373384000886 catalytic triad [active] 373384000887 dimer interface [polypeptide binding]; other site 373384000888 multimer interface [polypeptide binding]; other site 373384000889 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 373384000890 RHS Repeat; Region: RHS_repeat; cl11982 373384000891 RHS protein; Region: RHS; pfam03527 373384000892 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 373384000893 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 373384000894 RHS Repeat; Region: RHS_repeat; pfam05593 373384000895 RHS Repeat; Region: RHS_repeat; pfam05593 373384000896 PAAR motif; Region: PAAR_motif; pfam05488 373384000897 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 373384000898 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 373384000899 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 373384000900 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 373384000901 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384000902 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 373384000903 Cysteine-rich domain; Region: CCG; pfam02754 373384000904 Cysteine-rich domain; Region: CCG; pfam02754 373384000905 iron-sulfur cluster-binding protein; Region: TIGR00273 373384000906 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 373384000907 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384000908 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 373384000909 Uncharacterized conserved protein [Function unknown]; Region: COG1556 373384000910 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373384000911 choline dehydrogenase; Validated; Region: PRK02106 373384000912 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 373384000913 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 373384000914 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 373384000915 tetrameric interface [polypeptide binding]; other site 373384000916 NAD binding site [chemical binding]; other site 373384000917 catalytic residues [active] 373384000918 transcriptional regulator BetI; Validated; Region: PRK00767 373384000919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384000920 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 373384000921 choline transport protein BetT; Provisional; Region: PRK09928 373384000922 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384000923 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 373384000924 Integrase core domain; Region: rve; pfam00665 373384000925 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 373384000926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384000927 substrate binding pocket [chemical binding]; other site 373384000928 membrane-bound complex binding site; other site 373384000929 hinge residues; other site 373384000930 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 373384000931 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 373384000932 Walker A/P-loop; other site 373384000933 ATP binding site [chemical binding]; other site 373384000934 Q-loop/lid; other site 373384000935 ABC transporter signature motif; other site 373384000936 Walker B; other site 373384000937 D-loop; other site 373384000938 H-loop/switch region; other site 373384000939 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 373384000940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384000941 dimer interface [polypeptide binding]; other site 373384000942 conserved gate region; other site 373384000943 putative PBP binding loops; other site 373384000944 ABC-ATPase subunit interface; other site 373384000945 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 373384000946 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 373384000947 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 373384000948 dimer interface [polypeptide binding]; other site 373384000949 active site 373384000950 Schiff base residues; other site 373384000951 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384000952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384000953 HTH-like domain; Region: HTH_21; pfam13276 373384000954 Integrase core domain; Region: rve; pfam00665 373384000955 putative transposase OrfB; Reviewed; Region: PHA02517 373384000956 HTH-like domain; Region: HTH_21; pfam13276 373384000957 Integrase core domain; Region: rve; pfam00665 373384000958 Integrase core domain; Region: rve_2; pfam13333 373384000959 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 373384000960 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 373384000961 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 373384000962 microcin B17 transporter; Reviewed; Region: PRK11098 373384000963 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 373384000964 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 373384000965 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 373384000966 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 373384000967 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 373384000968 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 373384000969 anti-RssB factor; Provisional; Region: PRK10244 373384000970 alkaline phosphatase; Provisional; Region: PRK10518 373384000971 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 373384000972 dimer interface [polypeptide binding]; other site 373384000973 active site 373384000974 hypothetical protein; Provisional; Region: PRK11505 373384000975 psiF repeat; Region: PsiF_repeat; pfam07769 373384000976 psiF repeat; Region: PsiF_repeat; pfam07769 373384000977 putative transposase OrfB; Reviewed; Region: PHA02517 373384000978 HTH-like domain; Region: HTH_21; pfam13276 373384000979 Integrase core domain; Region: rve; pfam00665 373384000980 Integrase core domain; Region: rve_3; pfam13683 373384000981 Transposase; Region: HTH_Tnp_1; cl17663 373384000982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384000983 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 373384000984 MASE2 domain; Region: MASE2; pfam05230 373384000985 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384000986 metal binding site [ion binding]; metal-binding site 373384000987 active site 373384000988 I-site; other site 373384000989 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 373384000990 pyrroline-5-carboxylate reductase; Region: PLN02688 373384000991 hypothetical protein; Validated; Region: PRK00124 373384000992 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 373384000993 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 373384000994 ADP binding site [chemical binding]; other site 373384000995 magnesium binding site [ion binding]; other site 373384000996 putative shikimate binding site; other site 373384000997 hypothetical protein; Provisional; Region: PRK10380 373384000998 hypothetical protein; Provisional; Region: PRK10481 373384000999 hypothetical protein; Provisional; Region: PRK10579 373384001000 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 373384001001 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 373384001002 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 373384001003 fructokinase; Reviewed; Region: PRK09557 373384001004 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373384001005 nucleotide binding site [chemical binding]; other site 373384001006 MFS transport protein AraJ; Provisional; Region: PRK10091 373384001007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384001008 putative substrate translocation pore; other site 373384001009 exonuclease subunit SbcC; Provisional; Region: PRK10246 373384001010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384001011 Walker A/P-loop; other site 373384001012 ATP binding site [chemical binding]; other site 373384001013 Q-loop/lid; other site 373384001014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384001015 ABC transporter signature motif; other site 373384001016 Walker B; other site 373384001017 D-loop; other site 373384001018 H-loop/switch region; other site 373384001019 exonuclease subunit SbcD; Provisional; Region: PRK10966 373384001020 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 373384001021 active site 373384001022 metal binding site [ion binding]; metal-binding site 373384001023 DNA binding site [nucleotide binding] 373384001024 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 373384001025 transcriptional regulator PhoB; Provisional; Region: PRK10161 373384001026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384001027 active site 373384001028 phosphorylation site [posttranslational modification] 373384001029 intermolecular recognition site; other site 373384001030 dimerization interface [polypeptide binding]; other site 373384001031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384001032 DNA binding site [nucleotide binding] 373384001033 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 373384001034 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 373384001035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373384001036 putative active site [active] 373384001037 heme pocket [chemical binding]; other site 373384001038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384001039 dimer interface [polypeptide binding]; other site 373384001040 phosphorylation site [posttranslational modification] 373384001041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384001042 ATP binding site [chemical binding]; other site 373384001043 Mg2+ binding site [ion binding]; other site 373384001044 G-X-G motif; other site 373384001045 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 373384001046 putative proline-specific permease; Provisional; Region: proY; PRK10580 373384001047 Spore germination protein; Region: Spore_permease; cl17796 373384001048 maltodextrin glucosidase; Provisional; Region: PRK10785 373384001049 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 373384001050 homodimer interface [polypeptide binding]; other site 373384001051 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 373384001052 active site 373384001053 homodimer interface [polypeptide binding]; other site 373384001054 catalytic site [active] 373384001055 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 373384001056 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 373384001057 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 373384001058 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 373384001059 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 373384001060 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 373384001061 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 373384001062 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 373384001063 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 373384001064 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 373384001065 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 373384001066 Protein export membrane protein; Region: SecD_SecF; pfam02355 373384001067 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 373384001068 active site 373384001069 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 373384001070 hypothetical protein; Provisional; Region: PRK11530 373384001071 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 373384001072 ATP cone domain; Region: ATP-cone; pfam03477 373384001073 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 373384001074 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 373384001075 catalytic motif [active] 373384001076 Zn binding site [ion binding]; other site 373384001077 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 373384001078 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 373384001079 homopentamer interface [polypeptide binding]; other site 373384001080 active site 373384001081 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 373384001082 putative RNA binding site [nucleotide binding]; other site 373384001083 thiamine monophosphate kinase; Provisional; Region: PRK05731 373384001084 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 373384001085 ATP binding site [chemical binding]; other site 373384001086 dimerization interface [polypeptide binding]; other site 373384001087 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 373384001088 tetramer interfaces [polypeptide binding]; other site 373384001089 binuclear metal-binding site [ion binding]; other site 373384001090 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384001091 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384001092 active site 373384001093 catalytic tetrad [active] 373384001094 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 373384001095 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 373384001096 TPP-binding site; other site 373384001097 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373384001098 PYR/PP interface [polypeptide binding]; other site 373384001099 dimer interface [polypeptide binding]; other site 373384001100 TPP binding site [chemical binding]; other site 373384001101 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373384001102 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 373384001103 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 373384001104 substrate binding pocket [chemical binding]; other site 373384001105 chain length determination region; other site 373384001106 substrate-Mg2+ binding site; other site 373384001107 catalytic residues [active] 373384001108 aspartate-rich region 1; other site 373384001109 active site lid residues [active] 373384001110 aspartate-rich region 2; other site 373384001111 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 373384001112 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 373384001113 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 373384001114 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 373384001115 Ligand Binding Site [chemical binding]; other site 373384001116 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373384001117 active site residue [active] 373384001118 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 373384001119 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 373384001120 conserved cys residue [active] 373384001121 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 373384001122 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 373384001123 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 373384001124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 373384001125 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 373384001126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 373384001127 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 373384001128 Sel1-like repeats; Region: SEL1; smart00671 373384001129 Sel1-like repeats; Region: SEL1; smart00671 373384001130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384001131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384001132 putative substrate translocation pore; other site 373384001133 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 373384001134 Sel1-like repeats; Region: SEL1; smart00671 373384001135 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 373384001136 Sel1-like repeats; Region: SEL1; smart00671 373384001137 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 373384001138 Sel1 repeat; Region: Sel1; pfam08238 373384001139 Sel1-like repeats; Region: SEL1; smart00671 373384001140 Sel1-like repeats; Region: SEL1; smart00671 373384001141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 373384001142 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 373384001143 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 373384001144 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 373384001145 Subunit I/III interface [polypeptide binding]; other site 373384001146 Subunit III/IV interface [polypeptide binding]; other site 373384001147 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 373384001148 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 373384001149 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384001150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384001151 Homeodomain-like domain; Region: HTH_23; pfam13384 373384001152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001153 Transposase; Region: HTH_Tnp_1; pfam01527 373384001154 muropeptide transporter; Reviewed; Region: ampG; PRK11902 373384001155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384001156 putative substrate translocation pore; other site 373384001157 hypothetical protein; Provisional; Region: PRK11627 373384001158 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 373384001159 trigger factor; Provisional; Region: tig; PRK01490 373384001160 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373384001161 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 373384001162 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 373384001163 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 373384001164 oligomer interface [polypeptide binding]; other site 373384001165 active site residues [active] 373384001166 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 373384001167 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 373384001168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384001169 Walker A motif; other site 373384001170 ATP binding site [chemical binding]; other site 373384001171 Walker B motif; other site 373384001172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 373384001173 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 373384001174 Found in ATP-dependent protease La (LON); Region: LON; smart00464 373384001175 Found in ATP-dependent protease La (LON); Region: LON; smart00464 373384001176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384001177 Walker A motif; other site 373384001178 ATP binding site [chemical binding]; other site 373384001179 Walker B motif; other site 373384001180 arginine finger; other site 373384001181 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 373384001182 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 373384001183 IHF dimer interface [polypeptide binding]; other site 373384001184 IHF - DNA interface [nucleotide binding]; other site 373384001185 periplasmic folding chaperone; Provisional; Region: PRK10788 373384001186 SurA N-terminal domain; Region: SurA_N_3; cl07813 373384001187 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 373384001188 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 373384001189 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 373384001190 active site 373384001191 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 373384001192 Ligand Binding Site [chemical binding]; other site 373384001193 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 373384001194 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 373384001195 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 373384001196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384001197 active site 373384001198 motif I; other site 373384001199 motif II; other site 373384001200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384001201 dimerization interface [polypeptide binding]; other site 373384001202 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 373384001203 putative DNA binding site [nucleotide binding]; other site 373384001204 putative Zn2+ binding site [ion binding]; other site 373384001205 AsnC family; Region: AsnC_trans_reg; pfam01037 373384001206 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373384001207 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 373384001208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384001209 Walker A/P-loop; other site 373384001210 ATP binding site [chemical binding]; other site 373384001211 Q-loop/lid; other site 373384001212 ABC transporter signature motif; other site 373384001213 Walker B; other site 373384001214 D-loop; other site 373384001215 H-loop/switch region; other site 373384001216 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 373384001217 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373384001218 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 373384001219 Walker A/P-loop; other site 373384001220 ATP binding site [chemical binding]; other site 373384001221 Q-loop/lid; other site 373384001222 ABC transporter signature motif; other site 373384001223 Walker B; other site 373384001224 D-loop; other site 373384001225 H-loop/switch region; other site 373384001226 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 373384001227 Nitrogen regulatory protein P-II; Region: P-II; smart00938 373384001228 ammonium transporter; Provisional; Region: PRK10666 373384001229 acyl-CoA thioesterase II; Provisional; Region: PRK10526 373384001230 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 373384001231 active site 373384001232 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 373384001233 catalytic triad [active] 373384001234 dimer interface [polypeptide binding]; other site 373384001235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 373384001236 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384001237 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384001238 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384001239 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 373384001240 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 373384001241 DNA binding site [nucleotide binding] 373384001242 active site 373384001243 Uncharacterized conserved protein [Function unknown]; Region: COG5507 373384001244 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 373384001245 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 373384001246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384001247 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 373384001248 maltose O-acetyltransferase; Provisional; Region: PRK10092 373384001249 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 373384001250 active site 373384001251 substrate binding site [chemical binding]; other site 373384001252 trimer interface [polypeptide binding]; other site 373384001253 CoA binding site [chemical binding]; other site 373384001254 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 373384001255 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 373384001256 Protein export membrane protein; Region: SecD_SecF; cl14618 373384001257 Protein export membrane protein; Region: SecD_SecF; cl14618 373384001258 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 373384001259 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384001260 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384001261 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 373384001262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384001263 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 373384001264 hypothetical protein; Provisional; Region: PRK11281 373384001265 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 373384001266 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 373384001267 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373384001268 hypothetical protein; Provisional; Region: PRK11038 373384001269 primosomal replication protein N''; Provisional; Region: PRK10093 373384001270 hypothetical protein; Provisional; Region: PRK10527 373384001271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384001272 active site 373384001273 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 373384001274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384001275 Walker A motif; other site 373384001276 ATP binding site [chemical binding]; other site 373384001277 Walker B motif; other site 373384001278 DNA polymerase III subunit delta'; Validated; Region: PRK08485 373384001279 arginine finger; other site 373384001280 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 373384001281 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 373384001282 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 373384001283 hypothetical protein; Validated; Region: PRK00153 373384001284 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 373384001285 RecR protein; Region: RecR; pfam02132 373384001286 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 373384001287 putative active site [active] 373384001288 putative metal-binding site [ion binding]; other site 373384001289 tetramer interface [polypeptide binding]; other site 373384001290 adenylate kinase; Reviewed; Region: adk; PRK00279 373384001291 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 373384001292 AMP-binding site [chemical binding]; other site 373384001293 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 373384001294 ferrochelatase; Region: hemH; TIGR00109 373384001295 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 373384001296 C-terminal domain interface [polypeptide binding]; other site 373384001297 active site 373384001298 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 373384001299 active site 373384001300 N-terminal domain interface [polypeptide binding]; other site 373384001301 acetyl esterase; Provisional; Region: PRK10162 373384001302 inosine/guanosine kinase; Provisional; Region: PRK15074 373384001303 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384001304 putative cation:proton antiport protein; Provisional; Region: PRK10669 373384001305 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 373384001306 TrkA-N domain; Region: TrkA_N; pfam02254 373384001307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384001308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384001309 putative substrate translocation pore; other site 373384001310 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 373384001311 putative deacylase active site [active] 373384001312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 373384001313 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 373384001314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384001315 non-specific DNA binding site [nucleotide binding]; other site 373384001316 salt bridge; other site 373384001317 sequence-specific DNA binding site [nucleotide binding]; other site 373384001318 copper exporting ATPase; Provisional; Region: copA; PRK10671 373384001319 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373384001320 metal-binding site [ion binding] 373384001321 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373384001322 metal-binding site [ion binding] 373384001323 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373384001324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384001325 motif II; other site 373384001326 glutaminase; Reviewed; Region: PRK12356 373384001327 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 373384001328 amino acid transporter; Region: 2A0306; TIGR00909 373384001329 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 373384001330 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 373384001331 DNA binding residues [nucleotide binding] 373384001332 dimer interface [polypeptide binding]; other site 373384001333 copper binding site [ion binding]; other site 373384001334 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 373384001335 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373384001336 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 373384001337 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 373384001338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384001339 Walker A/P-loop; other site 373384001340 ATP binding site [chemical binding]; other site 373384001341 Q-loop/lid; other site 373384001342 ABC transporter signature motif; other site 373384001343 Walker B; other site 373384001344 D-loop; other site 373384001345 H-loop/switch region; other site 373384001346 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 373384001347 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 373384001348 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 373384001349 oxidoreductase; Provisional; Region: PRK08017 373384001350 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 373384001351 NADP binding site [chemical binding]; other site 373384001352 active site 373384001353 steroid binding site; other site 373384001354 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 373384001355 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373384001356 Q-loop/lid; other site 373384001357 ABC transporter signature motif; other site 373384001358 Walker B; other site 373384001359 D-loop; other site 373384001360 H-loop/switch region; other site 373384001361 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 373384001362 FtsX-like permease family; Region: FtsX; pfam02687 373384001363 FtsX-like permease family; Region: FtsX; pfam02687 373384001364 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 373384001365 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 373384001366 active site residue [active] 373384001367 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 373384001368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384001369 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384001370 dimerization interface [polypeptide binding]; other site 373384001371 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 373384001372 ureidoglycolate hydrolase; Provisional; Region: PRK03606 373384001373 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 373384001374 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 373384001375 Bacterial transcriptional regulator; Region: IclR; pfam01614 373384001376 glyoxylate carboligase; Provisional; Region: PRK11269 373384001377 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373384001378 PYR/PP interface [polypeptide binding]; other site 373384001379 dimer interface [polypeptide binding]; other site 373384001380 TPP binding site [chemical binding]; other site 373384001381 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373384001382 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 373384001383 TPP-binding site [chemical binding]; other site 373384001384 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384001385 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 373384001386 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 373384001387 allantoate amidohydrolase; Region: AllC; TIGR03176 373384001388 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 373384001389 active site 373384001390 metal binding site [ion binding]; metal-binding site 373384001391 dimer interface [polypeptide binding]; other site 373384001392 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 373384001393 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 373384001394 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 373384001395 putative substrate binding site [chemical binding]; other site 373384001396 nucleotide binding site [chemical binding]; other site 373384001397 nucleotide binding site [chemical binding]; other site 373384001398 homodimer interface [polypeptide binding]; other site 373384001399 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 373384001400 ATP-grasp domain; Region: ATP-grasp; pfam02222 373384001401 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 373384001402 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 373384001403 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373384001404 putative active site [active] 373384001405 putative metal binding site [ion binding]; other site 373384001406 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 373384001407 substrate binding site [chemical binding]; other site 373384001408 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 373384001409 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373384001410 active site 373384001411 HIGH motif; other site 373384001412 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 373384001413 KMSKS motif; other site 373384001414 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 373384001415 tRNA binding surface [nucleotide binding]; other site 373384001416 anticodon binding site; other site 373384001417 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 373384001418 ribosome-associated protein; Provisional; Region: PRK11507 373384001419 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 373384001420 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 373384001421 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 373384001422 homodimer interface [polypeptide binding]; other site 373384001423 NADP binding site [chemical binding]; other site 373384001424 substrate binding site [chemical binding]; other site 373384001425 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 373384001426 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384001427 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 373384001428 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384001429 HTH-like domain; Region: HTH_21; pfam13276 373384001430 Integrase core domain; Region: rve; pfam00665 373384001431 Integrase core domain; Region: rve_3; pfam13683 373384001432 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384001433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001434 transcriptional regulator FimZ; Provisional; Region: PRK09935 373384001435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384001436 active site 373384001437 phosphorylation site [posttranslational modification] 373384001438 intermolecular recognition site; other site 373384001439 dimerization interface [polypeptide binding]; other site 373384001440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384001441 DNA binding residues [nucleotide binding] 373384001442 dimerization interface [polypeptide binding]; other site 373384001443 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 373384001444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384001445 hypothetical protein; Provisional; Region: PRK09936 373384001446 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 373384001447 active site 373384001448 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 373384001449 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 373384001450 sensor kinase CusS; Provisional; Region: PRK09835 373384001451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384001452 dimerization interface [polypeptide binding]; other site 373384001453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384001454 dimer interface [polypeptide binding]; other site 373384001455 phosphorylation site [posttranslational modification] 373384001456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384001457 ATP binding site [chemical binding]; other site 373384001458 Mg2+ binding site [ion binding]; other site 373384001459 G-X-G motif; other site 373384001460 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 373384001461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384001462 active site 373384001463 phosphorylation site [posttranslational modification] 373384001464 intermolecular recognition site; other site 373384001465 dimerization interface [polypeptide binding]; other site 373384001466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384001467 DNA binding site [nucleotide binding] 373384001468 periplasmic copper-binding protein; Provisional; Region: PRK09838 373384001469 Integrase core domain; Region: rve; pfam00665 373384001470 Integrase core domain; Region: rve_3; pfam13683 373384001471 Transposase; Region: HTH_Tnp_1; cl17663 373384001472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001473 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 373384001474 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 373384001475 HTH-like domain; Region: HTH_21; pfam13276 373384001476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384001477 Integrase core domain; Region: rve; pfam00665 373384001478 Integrase core domain; Region: rve_3; pfam13683 373384001479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001480 Transposase; Region: HTH_Tnp_1; pfam01527 373384001481 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384001482 HTH-like domain; Region: HTH_21; pfam13276 373384001483 Integrase core domain; Region: rve; pfam00665 373384001484 Integrase core domain; Region: rve_3; pfam13683 373384001485 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384001486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001487 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 373384001488 phenylalanine transporter; Provisional; Region: PRK10249 373384001489 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373384001490 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373384001491 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 373384001492 dimer interface [polypeptide binding]; other site 373384001493 FMN binding site [chemical binding]; other site 373384001494 hypothetical protein; Provisional; Region: PRK10250 373384001495 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 373384001496 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 373384001497 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 373384001498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001499 Helix-turn-helix domain; Region: HTH_28; pfam13518 373384001500 Helix-turn-helix domain; Region: HTH_28; pfam13518 373384001501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384001502 Integrase core domain; Region: rve; pfam00665 373384001503 Integrase core domain; Region: rve_3; pfam13683 373384001504 Integrase core domain; Region: rve; pfam00665 373384001505 Integrase core domain; Region: rve_3; pfam13683 373384001506 Transposase; Region: HTH_Tnp_1; cl17663 373384001507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001509 Transposase; Region: HTH_Tnp_1; pfam01527 373384001510 putative transposase OrfB; Reviewed; Region: PHA02517 373384001511 HTH-like domain; Region: HTH_21; pfam13276 373384001512 Integrase core domain; Region: rve; pfam00665 373384001513 Integrase core domain; Region: rve_2; pfam13333 373384001514 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 373384001515 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 373384001516 outer membrane receptor FepA; Provisional; Region: PRK13524 373384001517 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373384001518 N-terminal plug; other site 373384001519 ligand-binding site [chemical binding]; other site 373384001520 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 373384001521 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 373384001522 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 373384001523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 373384001524 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 373384001525 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 373384001526 acyl-activating enzyme (AAE) consensus motif; other site 373384001527 AMP binding site [chemical binding]; other site 373384001528 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 373384001529 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384001530 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 373384001531 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 373384001532 Walker A/P-loop; other site 373384001533 ATP binding site [chemical binding]; other site 373384001534 Q-loop/lid; other site 373384001535 ABC transporter signature motif; other site 373384001536 Walker B; other site 373384001537 D-loop; other site 373384001538 H-loop/switch region; other site 373384001539 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 373384001540 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384001541 ABC-ATPase subunit interface; other site 373384001542 dimer interface [polypeptide binding]; other site 373384001543 putative PBP binding regions; other site 373384001544 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 373384001545 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384001546 ABC-ATPase subunit interface; other site 373384001547 dimer interface [polypeptide binding]; other site 373384001548 putative PBP binding regions; other site 373384001549 enterobactin exporter EntS; Provisional; Region: PRK10489 373384001550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384001551 putative substrate translocation pore; other site 373384001552 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 373384001553 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 373384001554 siderophore binding site; other site 373384001555 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 373384001556 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 373384001557 acyl-activating enzyme (AAE) consensus motif; other site 373384001558 active site 373384001559 AMP binding site [chemical binding]; other site 373384001560 substrate binding site [chemical binding]; other site 373384001561 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 373384001562 hydrophobic substrate binding pocket; other site 373384001563 Isochorismatase family; Region: Isochorismatase; pfam00857 373384001564 active site 373384001565 conserved cis-peptide bond; other site 373384001566 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 373384001567 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 373384001568 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 373384001569 putative NAD(P) binding site [chemical binding]; other site 373384001570 active site 373384001571 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 373384001572 CoenzymeA binding site [chemical binding]; other site 373384001573 subunit interaction site [polypeptide binding]; other site 373384001574 PHB binding site; other site 373384001575 carbon starvation protein A; Provisional; Region: PRK15015 373384001576 Carbon starvation protein CstA; Region: CstA; pfam02554 373384001577 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 373384001578 Uncharacterized small protein [Function unknown]; Region: COG2879 373384001579 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 373384001580 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 373384001581 putative active site [active] 373384001582 metal binding site [ion binding]; metal-binding site 373384001583 methionine aminotransferase; Validated; Region: PRK09082 373384001584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384001585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384001586 homodimer interface [polypeptide binding]; other site 373384001587 catalytic residue [active] 373384001588 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 373384001589 ParB-like nuclease domain; Region: ParBc; pfam02195 373384001590 putative transposase OrfB; Reviewed; Region: PHA02517 373384001591 HTH-like domain; Region: HTH_21; pfam13276 373384001592 Integrase core domain; Region: rve; pfam00665 373384001593 Integrase core domain; Region: rve_3; pfam13683 373384001594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001595 Transposase; Region: HTH_Tnp_1; pfam01527 373384001596 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 373384001597 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 373384001598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384001599 Transposase; Region: HTH_Tnp_1; pfam01527 373384001600 putative transposase OrfB; Reviewed; Region: PHA02517 373384001601 HTH-like domain; Region: HTH_21; pfam13276 373384001602 Integrase core domain; Region: rve; pfam00665 373384001603 Integrase core domain; Region: rve_2; pfam13333 373384001604 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 373384001605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384001606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384001607 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 373384001608 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 373384001609 dimerization domain [polypeptide binding]; other site 373384001610 dimer interface [polypeptide binding]; other site 373384001611 catalytic residues [active] 373384001612 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 373384001613 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 373384001614 dimer interface [polypeptide binding]; other site 373384001615 decamer (pentamer of dimers) interface [polypeptide binding]; other site 373384001616 catalytic triad [active] 373384001617 peroxidatic and resolving cysteines [active] 373384001618 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 373384001619 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 373384001620 catalytic residue [active] 373384001621 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 373384001622 catalytic residues [active] 373384001623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373384001624 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373384001625 Ligand Binding Site [chemical binding]; other site 373384001626 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 373384001627 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373384001628 NAD binding site [chemical binding]; other site 373384001629 catalytic Zn binding site [ion binding]; other site 373384001630 structural Zn binding site [ion binding]; other site 373384001631 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 373384001632 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 373384001633 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 373384001634 B1 nucleotide binding pocket [chemical binding]; other site 373384001635 B2 nucleotide binding pocket [chemical binding]; other site 373384001636 CAS motifs; other site 373384001637 active site 373384001638 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373384001639 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 373384001640 transmembrane helices; other site 373384001641 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 373384001642 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 373384001643 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 373384001644 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 373384001645 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 373384001646 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384001647 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 373384001648 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 373384001649 dimer interface [polypeptide binding]; other site 373384001650 active site 373384001651 Int/Topo IB signature motif; other site 373384001652 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 373384001653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384001654 motif II; other site 373384001655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384001656 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 373384001657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384001658 Walker A/P-loop; other site 373384001659 ATP binding site [chemical binding]; other site 373384001660 Q-loop/lid; other site 373384001661 ABC transporter signature motif; other site 373384001662 Walker B; other site 373384001663 D-loop; other site 373384001664 H-loop/switch region; other site 373384001665 molybdenum-pterin binding domain; Region: Mop; TIGR00638 373384001666 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 373384001667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384001668 putative PBP binding loops; other site 373384001669 ABC-ATPase subunit interface; other site 373384001670 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 373384001671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384001672 substrate binding pocket [chemical binding]; other site 373384001673 membrane-bound complex binding site; other site 373384001674 hinge residues; other site 373384001675 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 373384001676 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 373384001677 molybdenum-pterin binding domain; Region: Mop; TIGR00638 373384001678 TOBE domain; Region: TOBE; pfam03459 373384001679 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 373384001680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 373384001681 Walker A/P-loop; other site 373384001682 ATP binding site [chemical binding]; other site 373384001683 Q-loop/lid; other site 373384001684 ABC transporter signature motif; other site 373384001685 Walker B; other site 373384001686 D-loop; other site 373384001687 H-loop/switch region; other site 373384001688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384001689 Walker A/P-loop; other site 373384001690 ATP binding site [chemical binding]; other site 373384001691 Q-loop/lid; other site 373384001692 ABC transporter signature motif; other site 373384001693 Walker B; other site 373384001694 D-loop; other site 373384001695 H-loop/switch region; other site 373384001696 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 373384001697 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 373384001698 NAD binding site [chemical binding]; other site 373384001699 homodimer interface [polypeptide binding]; other site 373384001700 active site 373384001701 substrate binding site [chemical binding]; other site 373384001702 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 373384001703 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 373384001704 dimer interface [polypeptide binding]; other site 373384001705 active site 373384001706 galactokinase; Provisional; Region: PRK05101 373384001707 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 373384001708 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373384001709 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 373384001710 active site 373384001711 catalytic residues [active] 373384001712 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373384001713 catalytic core [active] 373384001714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373384001715 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 373384001716 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 373384001717 YbgS-like protein; Region: YbgS; pfam13985 373384001718 zinc transporter ZitB; Provisional; Region: PRK03557 373384001719 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 373384001720 quinolinate synthetase; Provisional; Region: PRK09375 373384001721 tol-pal system protein YbgF; Provisional; Region: PRK10803 373384001722 Tetratricopeptide repeat; Region: TPR_6; pfam13174 373384001723 Tetratricopeptide repeat; Region: TPR_6; pfam13174 373384001724 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 373384001725 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373384001726 ligand binding site [chemical binding]; other site 373384001727 translocation protein TolB; Provisional; Region: tolB; PRK03629 373384001728 TolB amino-terminal domain; Region: TolB_N; pfam04052 373384001729 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 373384001730 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 373384001731 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 373384001732 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 373384001733 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 373384001734 TolA C-terminal; Region: TolA; pfam06519 373384001735 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 373384001736 colicin uptake protein TolR; Provisional; Region: PRK11024 373384001737 colicin uptake protein TolQ; Provisional; Region: PRK10801 373384001738 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 373384001739 active site 373384001740 hypothetical protein; Provisional; Region: PRK10588 373384001741 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 373384001742 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 373384001743 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 373384001744 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 373384001745 alpha-mannosidase; Provisional; Region: PRK09819 373384001746 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 373384001747 active site 373384001748 metal binding site [ion binding]; metal-binding site 373384001749 catalytic site [active] 373384001750 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 373384001751 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 373384001752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384001753 DNA-binding site [nucleotide binding]; DNA binding site 373384001754 UTRA domain; Region: UTRA; pfam07702 373384001755 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 373384001756 CoA binding domain; Region: CoA_binding; smart00881 373384001757 CoA-ligase; Region: Ligase_CoA; pfam00549 373384001758 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 373384001759 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 373384001760 CoA-ligase; Region: Ligase_CoA; pfam00549 373384001761 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 373384001762 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 373384001763 E3 interaction surface; other site 373384001764 lipoyl attachment site [posttranslational modification]; other site 373384001765 e3 binding domain; Region: E3_binding; pfam02817 373384001766 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 373384001767 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 373384001768 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 373384001769 TPP-binding site [chemical binding]; other site 373384001770 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 373384001771 dimer interface [polypeptide binding]; other site 373384001772 PYR/PP interface [polypeptide binding]; other site 373384001773 TPP binding site [chemical binding]; other site 373384001774 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 373384001775 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 373384001776 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 373384001777 L-aspartate oxidase; Provisional; Region: PRK06175 373384001778 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 373384001779 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 373384001780 SdhC subunit interface [polypeptide binding]; other site 373384001781 proximal heme binding site [chemical binding]; other site 373384001782 cardiolipin binding site; other site 373384001783 Iron-sulfur protein interface; other site 373384001784 proximal quinone binding site [chemical binding]; other site 373384001785 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 373384001786 Iron-sulfur protein interface; other site 373384001787 proximal quinone binding site [chemical binding]; other site 373384001788 SdhD (CybS) interface [polypeptide binding]; other site 373384001789 proximal heme binding site [chemical binding]; other site 373384001790 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 373384001791 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 373384001792 dimer interface [polypeptide binding]; other site 373384001793 active site 373384001794 citrylCoA binding site [chemical binding]; other site 373384001795 NADH binding [chemical binding]; other site 373384001796 cationic pore residues; other site 373384001797 oxalacetate/citrate binding site [chemical binding]; other site 373384001798 coenzyme A binding site [chemical binding]; other site 373384001799 catalytic triad [active] 373384001800 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 373384001801 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 373384001802 PapC N-terminal domain; Region: PapC_N; pfam13954 373384001803 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384001804 PapC C-terminal domain; Region: PapC_C; pfam13953 373384001805 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 373384001806 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384001807 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384001808 Fimbrial protein; Region: Fimbrial; pfam00419 373384001809 endonuclease VIII; Provisional; Region: PRK10445 373384001810 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 373384001811 DNA binding site [nucleotide binding] 373384001812 catalytic residue [active] 373384001813 putative catalytic residues [active] 373384001814 H2TH interface [polypeptide binding]; other site 373384001815 intercalation triad [nucleotide binding]; other site 373384001816 substrate specificity determining residue; other site 373384001817 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 373384001818 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 373384001819 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 373384001820 putative active site [active] 373384001821 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 373384001822 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 373384001823 Uncharacterized conserved protein [Function unknown]; Region: COG0327 373384001824 metal-binding protein; Provisional; Region: PRK10799 373384001825 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 373384001826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384001827 putative substrate translocation pore; other site 373384001828 POT family; Region: PTR2; pfam00854 373384001829 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 373384001830 DNA photolyase; Region: DNA_photolyase; pfam00875 373384001831 hypothetical protein; Provisional; Region: PRK10167 373384001832 Uncharacterized conserved protein [Function unknown]; Region: COG3272 373384001833 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 373384001834 PAAR motif; Region: PAAR_motif; pfam05488 373384001835 RHS Repeat; Region: RHS_repeat; cl11982 373384001836 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373384001837 RHS Repeat; Region: RHS_repeat; cl11982 373384001838 RHS Repeat; Region: RHS_repeat; pfam05593 373384001839 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 373384001840 RHS Repeat; Region: RHS_repeat; pfam05593 373384001841 RHS Repeat; Region: RHS_repeat; pfam05593 373384001842 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 373384001843 RHS Repeat; Region: RHS_repeat; pfam05593 373384001844 RHS Repeat; Region: RHS_repeat; pfam05593 373384001845 RHS Repeat; Region: RHS_repeat; pfam05593 373384001846 RHS protein; Region: RHS; pfam03527 373384001847 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 373384001848 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 373384001849 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384001850 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 373384001851 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 373384001852 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 373384001853 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 373384001854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384001855 active site 373384001856 phosphorylation site [posttranslational modification] 373384001857 intermolecular recognition site; other site 373384001858 dimerization interface [polypeptide binding]; other site 373384001859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384001860 DNA binding site [nucleotide binding] 373384001861 putrescine transporter; Provisional; Region: potE; PRK10655 373384001862 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 373384001863 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 373384001864 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 373384001865 active site 373384001866 substrate binding site [chemical binding]; other site 373384001867 metal binding site [ion binding]; metal-binding site 373384001868 replication initiation regulator SeqA; Provisional; Region: PRK11187 373384001869 acyl-CoA esterase; Provisional; Region: PRK10673 373384001870 PGAP1-like protein; Region: PGAP1; pfam07819 373384001871 LexA regulated protein; Provisional; Region: PRK11675 373384001872 flavodoxin FldA; Validated; Region: PRK09267 373384001873 ferric uptake regulator; Provisional; Region: fur; PRK09462 373384001874 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373384001875 metal binding site 2 [ion binding]; metal-binding site 373384001876 putative DNA binding helix; other site 373384001877 metal binding site 1 [ion binding]; metal-binding site 373384001878 dimer interface [polypeptide binding]; other site 373384001879 structural Zn2+ binding site [ion binding]; other site 373384001880 YbfN-like lipoprotein; Region: YbfN; pfam13982 373384001881 outer membrane porin, OprD family; Region: OprD; pfam03573 373384001882 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 373384001883 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373384001884 active site 373384001885 HIGH motif; other site 373384001886 nucleotide binding site [chemical binding]; other site 373384001887 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 373384001888 KMSKS motif; other site 373384001889 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 373384001890 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 373384001891 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 373384001892 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 373384001893 active site turn [active] 373384001894 phosphorylation site [posttranslational modification] 373384001895 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 373384001896 HPr interaction site; other site 373384001897 glycerol kinase (GK) interaction site [polypeptide binding]; other site 373384001898 active site 373384001899 phosphorylation site [posttranslational modification] 373384001900 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 373384001901 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 373384001902 active site 373384001903 trimer interface [polypeptide binding]; other site 373384001904 allosteric site; other site 373384001905 active site lid [active] 373384001906 hexamer (dimer of trimers) interface [polypeptide binding]; other site 373384001907 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 373384001908 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 373384001909 active site 373384001910 dimer interface [polypeptide binding]; other site 373384001911 MarR family; Region: MarR; pfam01047 373384001912 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373384001913 ROK family; Region: ROK; pfam00480 373384001914 UMP phosphatase; Provisional; Region: PRK10444 373384001915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384001916 active site 373384001917 motif I; other site 373384001918 motif II; other site 373384001919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384001920 asparagine synthetase B; Provisional; Region: asnB; PRK09431 373384001921 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 373384001922 active site 373384001923 dimer interface [polypeptide binding]; other site 373384001924 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 373384001925 Ligand Binding Site [chemical binding]; other site 373384001926 Molecular Tunnel; other site 373384001927 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 373384001928 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 373384001929 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 373384001930 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 373384001931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384001932 FeS/SAM binding site; other site 373384001933 TRAM domain; Region: TRAM; pfam01938 373384001934 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 373384001935 PhoH-like protein; Region: PhoH; pfam02562 373384001936 metal-binding heat shock protein; Provisional; Region: PRK00016 373384001937 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 373384001938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373384001939 Transporter associated domain; Region: CorC_HlyC; smart01091 373384001940 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 373384001941 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 373384001942 putative active site [active] 373384001943 catalytic triad [active] 373384001944 putative dimer interface [polypeptide binding]; other site 373384001945 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 373384001946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384001947 substrate binding pocket [chemical binding]; other site 373384001948 membrane-bound complex binding site; other site 373384001949 hinge residues; other site 373384001950 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373384001951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384001952 dimer interface [polypeptide binding]; other site 373384001953 conserved gate region; other site 373384001954 putative PBP binding loops; other site 373384001955 ABC-ATPase subunit interface; other site 373384001956 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373384001957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384001958 dimer interface [polypeptide binding]; other site 373384001959 conserved gate region; other site 373384001960 putative PBP binding loops; other site 373384001961 ABC-ATPase subunit interface; other site 373384001962 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373384001963 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 373384001964 Walker A/P-loop; other site 373384001965 ATP binding site [chemical binding]; other site 373384001966 Q-loop/lid; other site 373384001967 ABC transporter signature motif; other site 373384001968 Walker B; other site 373384001969 D-loop; other site 373384001970 H-loop/switch region; other site 373384001971 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 373384001972 active site 373384001973 tetramer interface [polypeptide binding]; other site 373384001974 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 373384001975 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 373384001976 nucleotide binding site [chemical binding]; other site 373384001977 putative NEF/HSP70 interaction site [polypeptide binding]; other site 373384001978 SBD interface [polypeptide binding]; other site 373384001979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 373384001980 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 373384001981 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 373384001982 Sel1-like repeats; Region: SEL1; smart00671 373384001983 Sel1-like repeats; Region: SEL1; smart00671 373384001984 Sel1-like repeats; Region: SEL1; smart00671 373384001985 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 373384001986 HSP70 interaction site [polypeptide binding]; other site 373384001987 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 373384001988 Sel1-like repeats; Region: SEL1; smart00671 373384001989 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 373384001990 Sel1-like repeats; Region: SEL1; smart00671 373384001991 Sel1-like repeats; Region: SEL1; smart00671 373384001992 Sel1-like repeats; Region: SEL1; smart00671 373384001993 Sel1-like repeats; Region: SEL1; smart00671 373384001994 Sel1-like repeats; Region: SEL1; smart00671 373384001995 Sel1-like repeats; Region: SEL1; smart00671 373384001996 hypothetical protein; Provisional; Region: PRK11032 373384001997 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 373384001998 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 373384001999 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 373384002000 HIGH motif; other site 373384002001 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 373384002002 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 373384002003 active site 373384002004 KMSKS motif; other site 373384002005 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 373384002006 tRNA binding surface [nucleotide binding]; other site 373384002007 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 373384002008 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 373384002009 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 373384002010 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 373384002011 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 373384002012 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 373384002013 active site 373384002014 (T/H)XGH motif; other site 373384002015 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373384002016 catalytic core [active] 373384002017 ribosome-associated protein; Provisional; Region: PRK11538 373384002018 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 373384002019 penicillin-binding protein 2; Provisional; Region: PRK10795 373384002020 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 373384002021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 373384002022 cell wall shape-determining protein; Provisional; Region: PRK10794 373384002023 rare lipoprotein A; Provisional; Region: PRK10672 373384002024 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 373384002025 Sporulation related domain; Region: SPOR; pfam05036 373384002026 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 373384002027 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 373384002028 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 373384002029 hypothetical protein; Provisional; Region: PRK04998 373384002030 lipoate-protein ligase B; Provisional; Region: PRK14342 373384002031 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 373384002032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384002033 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 373384002034 substrate binding pocket [chemical binding]; other site 373384002035 dimerization interface [polypeptide binding]; other site 373384002036 lipoyl synthase; Provisional; Region: PRK05481 373384002037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384002038 FeS/SAM binding site; other site 373384002039 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 373384002040 Predicted amidohydrolase [General function prediction only]; Region: COG0388 373384002041 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 373384002042 putative active site [active] 373384002043 catalytic triad [active] 373384002044 putative dimer interface [polypeptide binding]; other site 373384002045 chromosome condensation membrane protein; Provisional; Region: PRK14196 373384002046 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 373384002047 DNA-binding site [nucleotide binding]; DNA binding site 373384002048 RNA-binding motif; other site 373384002049 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 373384002050 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 373384002051 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 373384002052 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 373384002053 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 373384002054 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 373384002055 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 373384002056 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 373384002057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002058 Transposase; Region: HTH_Tnp_1; pfam01527 373384002059 HTH-like domain; Region: HTH_21; pfam13276 373384002060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384002061 Integrase core domain; Region: rve; pfam00665 373384002062 Integrase core domain; Region: rve_3; pfam13683 373384002063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 373384002064 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 373384002065 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 373384002066 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 373384002067 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 373384002068 Phage terminase large subunit; Region: Terminase_3; cl12054 373384002069 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384002070 HTH-like domain; Region: HTH_21; pfam13276 373384002071 Integrase core domain; Region: rve; pfam00665 373384002072 Integrase core domain; Region: rve_3; pfam13683 373384002073 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384002074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002075 Phage terminase large subunit; Region: Terminase_3; cl12054 373384002076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002077 Transposase; Region: HTH_Tnp_1; pfam01527 373384002078 Integrase core domain; Region: rve; pfam00665 373384002079 Integrase core domain; Region: rve_3; pfam13683 373384002080 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 373384002081 Integrase core domain; Region: rve_3; pfam13683 373384002082 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 373384002083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384002084 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 373384002085 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 373384002086 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 373384002087 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384002088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384002089 Homeodomain-like domain; Region: HTH_23; pfam13384 373384002090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002091 Transposase; Region: HTH_Tnp_1; pfam01527 373384002092 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 373384002093 catalytic residues [active] 373384002094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002095 Transposase; Region: HTH_Tnp_1; pfam01527 373384002096 HTH-like domain; Region: HTH_21; pfam13276 373384002097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384002098 Integrase core domain; Region: rve; pfam00665 373384002099 Integrase core domain; Region: rve_3; pfam13683 373384002100 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 373384002101 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 373384002102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 373384002103 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 373384002104 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 373384002105 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384002106 HTH-like domain; Region: HTH_21; pfam13276 373384002107 Integrase core domain; Region: rve; pfam00665 373384002108 Integrase core domain; Region: rve_3; pfam13683 373384002109 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384002110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002111 Ash protein family; Region: Phage_ASH; pfam10554 373384002112 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 373384002113 HTH-like domain; Region: HTH_21; pfam13276 373384002114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384002115 Integrase core domain; Region: rve; pfam00665 373384002116 Integrase core domain; Region: rve_3; pfam13683 373384002117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002118 Transposase; Region: HTH_Tnp_1; pfam01527 373384002119 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384002120 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 373384002121 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 373384002122 6-phosphogluconolactonase; Provisional; Region: PRK11028 373384002123 PrpF protein; Region: PrpF; pfam04303 373384002124 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373384002125 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 373384002126 transmembrane helices; other site 373384002127 putative hydratase; Provisional; Region: PRK11413 373384002128 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 373384002129 substrate binding site [chemical binding]; other site 373384002130 ligand binding site [chemical binding]; other site 373384002131 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 373384002132 substrate binding site [chemical binding]; other site 373384002133 acyl-CoA thioesterase; Provisional; Region: PRK10531 373384002134 putative pectinesterase; Region: PLN02432; cl01911 373384002135 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 373384002136 substrate binding site [chemical binding]; other site 373384002137 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 373384002138 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373384002139 inhibitor-cofactor binding pocket; inhibition site 373384002140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384002141 catalytic residue [active] 373384002142 biotin synthase; Provisional; Region: PRK15108 373384002143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384002144 FeS/SAM binding site; other site 373384002145 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 373384002146 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 373384002147 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 373384002148 substrate-cofactor binding pocket; other site 373384002149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384002150 catalytic residue [active] 373384002151 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 373384002152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384002153 S-adenosylmethionine binding site [chemical binding]; other site 373384002154 AAA domain; Region: AAA_26; pfam13500 373384002155 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373384002156 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 373384002157 ADP binding site [chemical binding]; other site 373384002158 excinuclease ABC subunit B; Provisional; Region: PRK05298 373384002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384002160 ATP binding site [chemical binding]; other site 373384002161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384002162 nucleotide binding region [chemical binding]; other site 373384002163 ATP-binding site [chemical binding]; other site 373384002164 Ultra-violet resistance protein B; Region: UvrB; pfam12344 373384002165 UvrB/uvrC motif; Region: UVR; pfam02151 373384002166 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 373384002167 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 373384002168 putative substrate binding pocket [chemical binding]; other site 373384002169 dimer interface [polypeptide binding]; other site 373384002170 phosphate binding site [ion binding]; other site 373384002171 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 373384002172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384002173 FeS/SAM binding site; other site 373384002174 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 373384002175 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 373384002176 MPT binding site; other site 373384002177 trimer interface [polypeptide binding]; other site 373384002178 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 373384002179 trimer interface [polypeptide binding]; other site 373384002180 dimer interface [polypeptide binding]; other site 373384002181 putative active site [active] 373384002182 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 373384002183 MoaE interaction surface [polypeptide binding]; other site 373384002184 MoeB interaction surface [polypeptide binding]; other site 373384002185 thiocarboxylated glycine; other site 373384002186 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 373384002187 MoaE homodimer interface [polypeptide binding]; other site 373384002188 MoaD interaction [polypeptide binding]; other site 373384002189 active site residues [active] 373384002190 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 373384002191 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 373384002192 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 373384002193 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 373384002194 Predicted integral membrane protein [Function unknown]; Region: COG0392 373384002195 cardiolipin synthase 2; Provisional; Region: PRK11263 373384002196 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 373384002197 putative active site [active] 373384002198 catalytic site [active] 373384002199 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 373384002200 putative active site [active] 373384002201 catalytic site [active] 373384002202 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 373384002203 putative catalytic site [active] 373384002204 putative metal binding site [ion binding]; other site 373384002205 putative phosphate binding site [ion binding]; other site 373384002206 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 373384002207 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 373384002208 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 373384002209 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 373384002210 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373384002211 Walker A/P-loop; other site 373384002212 ATP binding site [chemical binding]; other site 373384002213 Q-loop/lid; other site 373384002214 ABC transporter signature motif; other site 373384002215 Walker B; other site 373384002216 D-loop; other site 373384002217 H-loop/switch region; other site 373384002218 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 373384002219 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373384002220 Walker A/P-loop; other site 373384002221 ATP binding site [chemical binding]; other site 373384002222 Q-loop/lid; other site 373384002223 ABC transporter signature motif; other site 373384002224 Walker B; other site 373384002225 D-loop; other site 373384002226 H-loop/switch region; other site 373384002227 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 373384002228 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384002229 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384002230 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 373384002231 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 373384002232 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 373384002233 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 373384002234 ATP binding site [chemical binding]; other site 373384002235 Mg++ binding site [ion binding]; other site 373384002236 motif III; other site 373384002237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384002238 nucleotide binding region [chemical binding]; other site 373384002239 ATP-binding site [chemical binding]; other site 373384002240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 373384002241 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 373384002242 DEAD_2; Region: DEAD_2; pfam06733 373384002243 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 373384002244 glycosyl transferase family protein; Provisional; Region: PRK08136 373384002245 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 373384002246 putative dehydrogenase; Provisional; Region: PRK10098 373384002247 hypothetical protein; Provisional; Region: PRK10259 373384002248 hypothetical protein; Provisional; Region: PRK11019 373384002249 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 373384002250 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384002251 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384002252 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384002253 hypothetical protein; Provisional; Region: PRK10259 373384002254 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 373384002255 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 373384002256 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373384002257 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373384002258 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 373384002259 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 373384002260 Walker A/P-loop; other site 373384002261 ATP binding site [chemical binding]; other site 373384002262 Q-loop/lid; other site 373384002263 ABC transporter signature motif; other site 373384002264 Walker B; other site 373384002265 D-loop; other site 373384002266 H-loop/switch region; other site 373384002267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373384002268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384002269 dimer interface [polypeptide binding]; other site 373384002270 conserved gate region; other site 373384002271 putative PBP binding loops; other site 373384002272 ABC-ATPase subunit interface; other site 373384002273 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 373384002274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384002275 substrate binding pocket [chemical binding]; other site 373384002276 membrane-bound complex binding site; other site 373384002277 hinge residues; other site 373384002278 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 373384002279 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 373384002280 dimerization interface [polypeptide binding]; other site 373384002281 DPS ferroxidase diiron center [ion binding]; other site 373384002282 ion pore; other site 373384002283 threonine and homoserine efflux system; Provisional; Region: PRK10532 373384002284 EamA-like transporter family; Region: EamA; pfam00892 373384002285 outer membrane protein X; Provisional; Region: ompX; PRK09408 373384002286 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 373384002287 Sulfatase; Region: Sulfatase; pfam00884 373384002288 manganese transport regulator MntR; Provisional; Region: PRK11050 373384002289 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 373384002290 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 373384002291 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373384002292 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 373384002293 transmembrane helices; other site 373384002294 L,D-transpeptidase; Provisional; Region: PRK10260 373384002295 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373384002296 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 373384002297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384002298 Walker A/P-loop; other site 373384002299 ATP binding site [chemical binding]; other site 373384002300 Q-loop/lid; other site 373384002301 ABC transporter signature motif; other site 373384002302 Walker B; other site 373384002303 D-loop; other site 373384002304 H-loop/switch region; other site 373384002305 ABC transporter; Region: ABC_tran_2; pfam12848 373384002306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373384002307 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 373384002308 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 373384002309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384002310 active site 373384002311 motif I; other site 373384002312 motif II; other site 373384002313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384002314 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 373384002315 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 373384002316 dimer interface [polypeptide binding]; other site 373384002317 active site 373384002318 glycine loop; other site 373384002319 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 373384002320 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 373384002321 active site 373384002322 intersubunit interactions; other site 373384002323 catalytic residue [active] 373384002324 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 373384002325 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 373384002326 ATP binding site [chemical binding]; other site 373384002327 substrate interface [chemical binding]; other site 373384002328 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 373384002329 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 373384002330 dimer interface [polypeptide binding]; other site 373384002331 putative functional site; other site 373384002332 putative MPT binding site; other site 373384002333 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 373384002334 catalytic nucleophile [active] 373384002335 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 373384002336 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384002337 Walker A/P-loop; other site 373384002338 ATP binding site [chemical binding]; other site 373384002339 Q-loop/lid; other site 373384002340 ABC transporter signature motif; other site 373384002341 Walker B; other site 373384002342 D-loop; other site 373384002343 H-loop/switch region; other site 373384002344 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373384002345 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384002346 Walker A/P-loop; other site 373384002347 ATP binding site [chemical binding]; other site 373384002348 Q-loop/lid; other site 373384002349 ABC transporter signature motif; other site 373384002350 Walker B; other site 373384002351 D-loop; other site 373384002352 H-loop/switch region; other site 373384002353 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373384002354 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 373384002355 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 373384002356 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 373384002357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384002358 dimer interface [polypeptide binding]; other site 373384002359 conserved gate region; other site 373384002360 putative PBP binding loops; other site 373384002361 ABC-ATPase subunit interface; other site 373384002362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384002363 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373384002364 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384002365 metal binding site [ion binding]; metal-binding site 373384002366 active site 373384002367 I-site; other site 373384002368 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 373384002369 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 373384002370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384002371 FeS/SAM binding site; other site 373384002372 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 373384002373 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 373384002374 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 373384002375 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 373384002376 N-terminal domain interface [polypeptide binding]; other site 373384002377 dimer interface [polypeptide binding]; other site 373384002378 substrate binding pocket (H-site) [chemical binding]; other site 373384002379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002380 Transposase; Region: HTH_Tnp_1; pfam01527 373384002381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384002382 Integrase core domain; Region: rve; pfam00665 373384002383 Integrase core domain; Region: rve_3; pfam13683 373384002384 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 373384002385 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 373384002386 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384002387 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 373384002388 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 373384002389 active site 373384002390 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 373384002391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384002392 putative substrate translocation pore; other site 373384002393 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 373384002394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384002395 active site 373384002396 motif I; other site 373384002397 motif II; other site 373384002398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384002399 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 373384002400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384002401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384002402 putative substrate translocation pore; other site 373384002403 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 373384002404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384002405 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 373384002406 putative transporter; Provisional; Region: PRK04972 373384002407 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 373384002408 TrkA-C domain; Region: TrkA_C; pfam02080 373384002409 TrkA-C domain; Region: TrkA_C; pfam02080 373384002410 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 373384002411 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 373384002412 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 373384002413 GSH binding site [chemical binding]; other site 373384002414 catalytic residues [active] 373384002415 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 373384002416 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 373384002417 dimer interface [polypeptide binding]; other site 373384002418 FMN binding site [chemical binding]; other site 373384002419 NADPH bind site [chemical binding]; other site 373384002420 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 373384002421 RimK-like ATP-grasp domain; Region: RimK; pfam08443 373384002422 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 373384002423 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 373384002424 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 373384002425 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 373384002426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384002427 dimer interface [polypeptide binding]; other site 373384002428 conserved gate region; other site 373384002429 putative PBP binding loops; other site 373384002430 ABC-ATPase subunit interface; other site 373384002431 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 373384002432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384002433 dimer interface [polypeptide binding]; other site 373384002434 conserved gate region; other site 373384002435 putative PBP binding loops; other site 373384002436 ABC-ATPase subunit interface; other site 373384002437 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 373384002438 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 373384002439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384002440 S-adenosylmethionine binding site [chemical binding]; other site 373384002441 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 373384002442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384002443 substrate binding pocket [chemical binding]; other site 373384002444 membrane-bound complex binding site; other site 373384002445 hinge residues; other site 373384002446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384002447 dimer interface [polypeptide binding]; other site 373384002448 conserved gate region; other site 373384002449 putative PBP binding loops; other site 373384002450 ABC-ATPase subunit interface; other site 373384002451 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373384002452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384002453 dimer interface [polypeptide binding]; other site 373384002454 conserved gate region; other site 373384002455 putative PBP binding loops; other site 373384002456 ABC-ATPase subunit interface; other site 373384002457 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 373384002458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384002459 substrate binding pocket [chemical binding]; other site 373384002460 membrane-bound complex binding site; other site 373384002461 hinge residues; other site 373384002462 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 373384002463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384002464 Walker A/P-loop; other site 373384002465 ATP binding site [chemical binding]; other site 373384002466 Q-loop/lid; other site 373384002467 ABC transporter signature motif; other site 373384002468 Walker B; other site 373384002469 D-loop; other site 373384002470 H-loop/switch region; other site 373384002471 putative lipoprotein; Provisional; Region: PRK10533 373384002472 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002473 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 373384002474 hypothetical protein; Provisional; Region: PRK02877 373384002475 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 373384002476 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 373384002477 amidase catalytic site [active] 373384002478 Zn binding residues [ion binding]; other site 373384002479 substrate binding site [chemical binding]; other site 373384002480 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373384002481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373384002482 NAD(P) binding site [chemical binding]; other site 373384002483 active site 373384002484 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 373384002485 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 373384002486 putative NAD(P) binding site [chemical binding]; other site 373384002487 putative active site [active] 373384002488 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 373384002489 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 373384002490 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 373384002491 tetramer interface [polypeptide binding]; other site 373384002492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384002493 catalytic residue [active] 373384002494 pyruvate dehydrogenase; Provisional; Region: PRK09124 373384002495 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 373384002496 PYR/PP interface [polypeptide binding]; other site 373384002497 dimer interface [polypeptide binding]; other site 373384002498 tetramer interface [polypeptide binding]; other site 373384002499 TPP binding site [chemical binding]; other site 373384002500 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373384002501 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 373384002502 TPP-binding site [chemical binding]; other site 373384002503 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 373384002504 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 373384002505 FAD binding pocket [chemical binding]; other site 373384002506 FAD binding motif [chemical binding]; other site 373384002507 phosphate binding motif [ion binding]; other site 373384002508 beta-alpha-beta structure motif; other site 373384002509 NAD binding pocket [chemical binding]; other site 373384002510 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373384002511 catalytic loop [active] 373384002512 iron binding site [ion binding]; other site 373384002513 hybrid cluster protein; Provisional; Region: PRK05290 373384002514 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384002515 ACS interaction site; other site 373384002516 CODH interaction site; other site 373384002517 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 373384002518 hybrid metal cluster; other site 373384002519 Predicted membrane protein [Function unknown]; Region: COG2431 373384002520 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 373384002521 amphipathic channel; other site 373384002522 Asn-Pro-Ala signature motifs; other site 373384002523 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002524 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 373384002525 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 373384002526 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 373384002527 putative active site [active] 373384002528 putative metal-binding site [ion binding]; other site 373384002529 Protein of unknown function (DUF535); Region: DUF535; pfam04393 373384002530 macrolide transporter subunit MacA; Provisional; Region: PRK11578 373384002531 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384002532 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384002533 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 373384002534 DNA-binding site [nucleotide binding]; DNA binding site 373384002535 RNA-binding motif; other site 373384002536 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 373384002537 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 373384002538 Clp amino terminal domain; Region: Clp_N; pfam02861 373384002539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384002540 Walker A motif; other site 373384002541 ATP binding site [chemical binding]; other site 373384002542 Walker B motif; other site 373384002543 arginine finger; other site 373384002544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384002545 Walker A motif; other site 373384002546 ATP binding site [chemical binding]; other site 373384002547 Walker B motif; other site 373384002548 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 373384002549 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 373384002550 rRNA binding site [nucleotide binding]; other site 373384002551 predicted 30S ribosome binding site; other site 373384002552 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 373384002553 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 373384002554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373384002555 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 373384002556 Walker A/P-loop; other site 373384002557 ATP binding site [chemical binding]; other site 373384002558 Q-loop/lid; other site 373384002559 ABC transporter signature motif; other site 373384002560 Walker B; other site 373384002561 D-loop; other site 373384002562 H-loop/switch region; other site 373384002563 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 373384002564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373384002565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384002566 Walker A/P-loop; other site 373384002567 ATP binding site [chemical binding]; other site 373384002568 Q-loop/lid; other site 373384002569 ABC transporter signature motif; other site 373384002570 Walker B; other site 373384002571 D-loop; other site 373384002572 H-loop/switch region; other site 373384002573 thioredoxin reductase; Provisional; Region: PRK10262 373384002574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373384002575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384002576 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 373384002577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384002578 putative DNA binding site [nucleotide binding]; other site 373384002579 putative Zn2+ binding site [ion binding]; other site 373384002580 AsnC family; Region: AsnC_trans_reg; pfam01037 373384002581 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 373384002582 DNA translocase FtsK; Provisional; Region: PRK10263 373384002583 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 373384002584 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 373384002585 periplasmic chaperone LolA; Region: lolA; TIGR00547 373384002586 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 373384002587 recombination factor protein RarA; Reviewed; Region: PRK13342 373384002588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384002589 Walker A motif; other site 373384002590 ATP binding site [chemical binding]; other site 373384002591 Walker B motif; other site 373384002592 arginine finger; other site 373384002593 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 373384002594 seryl-tRNA synthetase; Provisional; Region: PRK05431 373384002595 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 373384002596 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 373384002597 dimer interface [polypeptide binding]; other site 373384002598 active site 373384002599 motif 1; other site 373384002600 motif 2; other site 373384002601 motif 3; other site 373384002602 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 373384002603 4Fe-4S binding domain; Region: Fer4; pfam00037 373384002604 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 373384002605 Isochorismatase family; Region: Isochorismatase; pfam00857 373384002606 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 373384002607 catalytic triad [active] 373384002608 dimer interface [polypeptide binding]; other site 373384002609 conserved cis-peptide bond; other site 373384002610 putative MFS family transporter protein; Provisional; Region: PRK03633 373384002611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384002612 putative substrate translocation pore; other site 373384002613 Homeodomain-like domain; Region: HTH_23; pfam13384 373384002614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002615 Transposase; Region: HTH_Tnp_1; pfam01527 373384002616 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384002617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384002618 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 373384002619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384002620 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 373384002621 Transposase; Region: HTH_Tnp_1; cl17663 373384002622 Integrase core domain; Region: rve; pfam00665 373384002623 Integrase core domain; Region: rve_3; pfam13683 373384002624 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 373384002625 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373384002627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384002628 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 373384002629 putative effector binding pocket; other site 373384002630 putative dimerization interface [polypeptide binding]; other site 373384002631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002632 Transposase; Region: HTH_Tnp_1; pfam01527 373384002633 HTH-like domain; Region: HTH_21; pfam13276 373384002634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384002635 Integrase core domain; Region: rve; pfam00665 373384002636 Integrase core domain; Region: rve_3; pfam13683 373384002637 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 373384002638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384002639 FeS/SAM binding site; other site 373384002640 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 373384002641 Pyruvate formate lyase 1; Region: PFL1; cd01678 373384002642 coenzyme A binding site [chemical binding]; other site 373384002643 active site 373384002644 catalytic residues [active] 373384002645 glycine loop; other site 373384002646 formate transporter; Provisional; Region: PRK10805 373384002647 uncharacterized domain; Region: TIGR00702 373384002648 YcaO-like family; Region: YcaO; pfam02624 373384002649 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 373384002650 homodimer interface [polypeptide binding]; other site 373384002651 substrate-cofactor binding pocket; other site 373384002652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384002653 catalytic residue [active] 373384002654 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 373384002655 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 373384002656 hinge; other site 373384002657 active site 373384002658 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384002659 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384002660 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384002661 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373384002662 cytidylate kinase; Provisional; Region: cmk; PRK00023 373384002663 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 373384002664 CMP-binding site; other site 373384002665 The sites determining sugar specificity; other site 373384002666 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 373384002667 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 373384002668 RNA binding site [nucleotide binding]; other site 373384002669 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 373384002670 RNA binding site [nucleotide binding]; other site 373384002671 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 373384002672 RNA binding site [nucleotide binding]; other site 373384002673 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 373384002674 RNA binding site [nucleotide binding]; other site 373384002675 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 373384002676 RNA binding site [nucleotide binding]; other site 373384002677 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 373384002678 IHF dimer interface [polypeptide binding]; other site 373384002679 IHF - DNA interface [nucleotide binding]; other site 373384002680 ComEC family competence protein; Provisional; Region: PRK11539 373384002681 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 373384002682 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 373384002683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 373384002684 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 373384002685 Walker A/P-loop; other site 373384002686 ATP binding site [chemical binding]; other site 373384002687 Q-loop/lid; other site 373384002688 ABC transporter signature motif; other site 373384002689 Walker B; other site 373384002690 D-loop; other site 373384002691 H-loop/switch region; other site 373384002692 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 373384002693 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 373384002694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 373384002695 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 373384002696 hypothetical protein; Provisional; Region: PRK11827 373384002697 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 373384002698 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 373384002699 Ligand binding site; other site 373384002700 oligomer interface; other site 373384002701 hypothetical protein; Provisional; Region: PRK10593 373384002702 Uncharacterized conserved protein [Function unknown]; Region: COG1434 373384002703 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373384002704 putative active site [active] 373384002705 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373384002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384002707 S-adenosylmethionine binding site [chemical binding]; other site 373384002708 condesin subunit F; Provisional; Region: PRK05260 373384002709 condesin subunit E; Provisional; Region: PRK05256 373384002710 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 373384002711 MukB N-terminal; Region: MukB; pfam04310 373384002712 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 373384002713 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384002714 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384002715 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384002716 murein L,D-transpeptidase; Provisional; Region: PRK10594 373384002717 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 373384002718 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373384002719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 373384002720 Peptidase M15; Region: Peptidase_M15_3; cl01194 373384002721 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 373384002722 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 373384002723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384002724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384002725 homodimer interface [polypeptide binding]; other site 373384002726 catalytic residue [active] 373384002727 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 373384002728 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 373384002729 trimer interface [polypeptide binding]; other site 373384002730 eyelet of channel; other site 373384002731 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 373384002732 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 373384002733 putative dimer interface [polypeptide binding]; other site 373384002734 putative anticodon binding site; other site 373384002735 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 373384002736 homodimer interface [polypeptide binding]; other site 373384002737 motif 1; other site 373384002738 motif 2; other site 373384002739 active site 373384002740 motif 3; other site 373384002741 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 373384002742 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 373384002743 active site 373384002744 aminopeptidase N; Provisional; Region: pepN; PRK14015 373384002745 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 373384002746 active site 373384002747 Zn binding site [ion binding]; other site 373384002748 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 373384002749 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 373384002750 Walker A/P-loop; other site 373384002751 ATP binding site [chemical binding]; other site 373384002752 Q-loop/lid; other site 373384002753 ABC transporter signature motif; other site 373384002754 Walker B; other site 373384002755 D-loop; other site 373384002756 H-loop/switch region; other site 373384002757 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 373384002758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384002759 dimer interface [polypeptide binding]; other site 373384002760 conserved gate region; other site 373384002761 putative PBP binding loops; other site 373384002762 ABC-ATPase subunit interface; other site 373384002763 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384002764 HTH-like domain; Region: HTH_21; pfam13276 373384002765 Integrase core domain; Region: rve; pfam00665 373384002766 Integrase core domain; Region: rve_3; pfam13683 373384002767 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384002768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002769 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 373384002770 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 373384002771 active site 373384002772 dimer interface [polypeptide binding]; other site 373384002773 non-prolyl cis peptide bond; other site 373384002774 insertion regions; other site 373384002775 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384002776 substrate binding pocket [chemical binding]; other site 373384002777 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 373384002778 membrane-bound complex binding site; other site 373384002779 hinge residues; other site 373384002780 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 373384002781 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373384002782 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002783 Fimbrial protein; Region: Fimbrial; cl01416 373384002784 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002785 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002786 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 373384002787 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384002788 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384002789 outer membrane usher protein; Provisional; Region: PRK15193 373384002790 PapC N-terminal domain; Region: PapC_N; pfam13954 373384002791 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384002792 PapC C-terminal domain; Region: PapC_C; pfam13953 373384002793 Fimbrial protein; Region: Fimbrial; cl01416 373384002794 Fimbrial protein; Region: Fimbrial; cl01416 373384002795 Fimbrial protein; Region: Fimbrial; cl01416 373384002796 putativi pili assembly chaperone; Provisional; Region: PRK11385 373384002797 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384002798 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384002799 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 373384002800 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 373384002801 quinone interaction residues [chemical binding]; other site 373384002802 active site 373384002803 catalytic residues [active] 373384002804 FMN binding site [chemical binding]; other site 373384002805 substrate binding site [chemical binding]; other site 373384002806 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 373384002807 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 373384002808 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 373384002809 MOSC domain; Region: MOSC; pfam03473 373384002810 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373384002811 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373384002812 catalytic loop [active] 373384002813 iron binding site [ion binding]; other site 373384002814 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 373384002815 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 373384002816 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 373384002817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384002818 S-adenosylmethionine binding site [chemical binding]; other site 373384002819 ABC transporter ATPase component; Reviewed; Region: PRK11147 373384002820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384002821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384002822 Walker A/P-loop; other site 373384002823 Walker A/P-loop; other site 373384002824 ATP binding site [chemical binding]; other site 373384002825 ATP binding site [chemical binding]; other site 373384002826 Q-loop/lid; other site 373384002827 Q-loop/lid; other site 373384002828 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373384002829 ABC transporter signature motif; other site 373384002830 Walker B; other site 373384002831 D-loop; other site 373384002832 ABC transporter; Region: ABC_tran_2; pfam12848 373384002833 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373384002834 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 373384002835 Paraquat-inducible protein A; Region: PqiA; pfam04403 373384002836 Paraquat-inducible protein A; Region: PqiA; pfam04403 373384002837 paraquat-inducible protein B; Provisional; Region: PRK10807 373384002838 mce related protein; Region: MCE; pfam02470 373384002839 mce related protein; Region: MCE; pfam02470 373384002840 mce related protein; Region: MCE; pfam02470 373384002841 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 373384002842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 373384002843 Protein of unknown function (DUF330); Region: DUF330; pfam03886 373384002844 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 373384002845 active site 1 [active] 373384002846 dimer interface [polypeptide binding]; other site 373384002847 active site 2 [active] 373384002848 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 373384002849 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 373384002850 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 373384002851 outer membrane protein A; Reviewed; Region: PRK10808 373384002852 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 373384002853 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373384002854 ligand binding site [chemical binding]; other site 373384002855 cell division inhibitor SulA; Region: sula; TIGR00623 373384002856 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384002857 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384002858 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384002859 HTH-like domain; Region: HTH_21; pfam13276 373384002860 Integrase core domain; Region: rve; pfam00665 373384002861 Integrase core domain; Region: rve_3; pfam13683 373384002862 TIGR01666 family membrane protein; Region: YCCS 373384002863 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 373384002864 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 373384002865 Predicted membrane protein [Function unknown]; Region: COG3304 373384002866 Domain of unknown function (DUF307); Region: DUF307; pfam03733 373384002867 Domain of unknown function (DUF307); Region: DUF307; pfam03733 373384002868 DNA helicase IV; Provisional; Region: helD; PRK11054 373384002869 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 373384002870 Part of AAA domain; Region: AAA_19; pfam13245 373384002871 Family description; Region: UvrD_C_2; pfam13538 373384002872 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 373384002873 active site 373384002874 dimer interfaces [polypeptide binding]; other site 373384002875 catalytic residues [active] 373384002876 hypothetical protein; Provisional; Region: PRK03641 373384002877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 373384002878 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 373384002879 heat shock protein HspQ; Provisional; Region: PRK14129 373384002880 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 373384002881 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 373384002882 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 373384002883 putative RNA binding site [nucleotide binding]; other site 373384002884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384002885 S-adenosylmethionine binding site [chemical binding]; other site 373384002886 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 373384002887 sulfur transfer protein TusE; Provisional; Region: PRK11508 373384002888 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 373384002889 YccA-like proteins; Region: YccA_like; cd10433 373384002890 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 373384002891 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 373384002892 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 373384002893 hydrogenase 1 large subunit; Provisional; Region: PRK10170 373384002894 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 373384002895 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 373384002896 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 373384002897 putative substrate-binding site; other site 373384002898 nickel binding site [ion binding]; other site 373384002899 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 373384002900 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 373384002901 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 373384002902 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 373384002903 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 373384002904 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 373384002905 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 373384002906 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 373384002907 catalytic core [active] 373384002908 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 373384002909 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 373384002910 Chain length determinant protein; Region: Wzz; pfam02706 373384002911 Chain length determinant protein; Region: Wzz; cl15801 373384002912 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373384002913 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 373384002914 Nucleotide binding site [chemical binding]; other site 373384002915 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373384002916 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 373384002917 active site 373384002918 polysaccharide export protein Wza; Provisional; Region: PRK15078 373384002919 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 373384002920 SLBB domain; Region: SLBB; pfam10531 373384002921 SLBB domain; Region: SLBB; pfam10531 373384002922 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 373384002923 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 373384002924 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 373384002925 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 373384002926 DNA-binding site [nucleotide binding]; DNA binding site 373384002927 RNA-binding motif; other site 373384002928 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002929 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 373384002930 DNA-binding site [nucleotide binding]; DNA binding site 373384002931 RNA-binding motif; other site 373384002932 GnsA/GnsB family; Region: GnsAB; pfam08178 373384002933 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 373384002934 4Fe-4S binding domain; Region: Fer4_5; pfam12801 373384002935 4Fe-4S binding domain; Region: Fer4_5; pfam12801 373384002936 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384002937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384002938 dimer interface [polypeptide binding]; other site 373384002939 phosphorylation site [posttranslational modification] 373384002940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384002941 ATP binding site [chemical binding]; other site 373384002942 Mg2+ binding site [ion binding]; other site 373384002943 G-X-G motif; other site 373384002944 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 373384002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384002946 active site 373384002947 phosphorylation site [posttranslational modification] 373384002948 intermolecular recognition site; other site 373384002949 dimerization interface [polypeptide binding]; other site 373384002950 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373384002951 putative binding surface; other site 373384002952 active site 373384002953 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 373384002954 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 373384002955 putative ligand binding site [chemical binding]; other site 373384002956 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 373384002957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384002958 active site 373384002959 phosphorylation site [posttranslational modification] 373384002960 intermolecular recognition site; other site 373384002961 dimerization interface [polypeptide binding]; other site 373384002962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384002963 DNA binding site [nucleotide binding] 373384002964 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 373384002965 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 373384002966 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 373384002967 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 373384002968 molybdopterin cofactor binding site [chemical binding]; other site 373384002969 substrate binding site [chemical binding]; other site 373384002970 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 373384002971 molybdopterin cofactor binding site; other site 373384002972 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384002973 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 373384002974 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 373384002975 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 373384002976 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373384002977 HSP70 interaction site [polypeptide binding]; other site 373384002978 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 373384002979 substrate binding site [polypeptide binding]; other site 373384002980 dimer interface [polypeptide binding]; other site 373384002981 hypothetical protein; Provisional; Region: PRK09784 373384002982 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 373384002983 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 373384002984 catalytic core [active] 373384002985 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 373384002986 hypothetical protein; Provisional; Region: PRK10174 373384002987 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 373384002988 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373384002989 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 373384002990 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 373384002991 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 373384002992 putative FMN binding site [chemical binding]; other site 373384002993 pyrimidine utilization protein D; Region: RutD; TIGR03611 373384002994 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 373384002995 homotrimer interaction site [polypeptide binding]; other site 373384002996 putative active site [active] 373384002997 Isochorismatase family; Region: Isochorismatase; pfam00857 373384002998 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 373384002999 catalytic triad [active] 373384003000 conserved cis-peptide bond; other site 373384003001 pyrimidine utilization protein A; Region: RutA; TIGR03612 373384003002 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 373384003003 active site 373384003004 dimer interface [polypeptide binding]; other site 373384003005 non-prolyl cis peptide bond; other site 373384003006 insertion regions; other site 373384003007 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 373384003008 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 373384003009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384003010 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 373384003011 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 373384003012 Putative transposase; Region: Y2_Tnp; pfam04986 373384003013 Iron permease FTR1 family; Region: FTR1; cl00475 373384003014 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 373384003015 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 373384003016 Imelysin; Region: Peptidase_M75; pfam09375 373384003017 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 373384003018 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 373384003019 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 373384003020 N-glycosyltransferase; Provisional; Region: PRK11204 373384003021 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 373384003022 DXD motif; other site 373384003023 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 373384003024 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384003025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373384003026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384003027 I-site; other site 373384003028 active site 373384003029 metal binding site [ion binding]; metal-binding site 373384003030 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 373384003031 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384003032 putative transposase OrfB; Reviewed; Region: PHA02517 373384003033 HTH-like domain; Region: HTH_21; pfam13276 373384003034 Integrase core domain; Region: rve; pfam00665 373384003035 Integrase core domain; Region: rve_2; pfam13333 373384003036 Transposase; Region: HTH_Tnp_1; cl17663 373384003037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003038 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 373384003039 putative hydrolase; Validated; Region: PRK09248 373384003040 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 373384003041 active site 373384003042 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 373384003043 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 373384003044 curli assembly protein CsgF; Provisional; Region: PRK10050 373384003045 curli assembly protein CsgE; Provisional; Region: PRK10386 373384003046 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 373384003047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384003048 DNA binding residues [nucleotide binding] 373384003049 dimerization interface [polypeptide binding]; other site 373384003050 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 373384003051 Curlin associated repeat; Region: Curlin_rpt; pfam07012 373384003052 Curlin associated repeat; Region: Curlin_rpt; pfam07012 373384003053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003054 Transposase; Region: HTH_Tnp_1; pfam01527 373384003055 Integrase core domain; Region: rve; pfam00665 373384003056 Fimbrial protein; Region: Fimbrial; cl01416 373384003057 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 373384003058 putative ADP-ribose binding site [chemical binding]; other site 373384003059 putative active site [active] 373384003060 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 373384003061 Acyltransferase family; Region: Acyl_transf_3; pfam01757 373384003062 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 373384003063 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 373384003064 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 373384003065 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 373384003066 Ligand binding site; other site 373384003067 DXD motif; other site 373384003068 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 373384003069 Putative transposase; Region: Y2_Tnp; pfam04986 373384003070 tape measure domain; Region: tape_meas_nterm; TIGR02675 373384003071 Integrase core domain; Region: rve; pfam00665 373384003072 Integrase core domain; Region: rve_3; pfam13683 373384003073 Transposase; Region: HTH_Tnp_1; cl17663 373384003074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003076 Transposase; Region: HTH_Tnp_1; pfam01527 373384003077 Integrase core domain; Region: rve; pfam00665 373384003078 Integrase core domain; Region: rve_3; pfam13683 373384003079 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384003080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003081 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384003082 HTH-like domain; Region: HTH_21; pfam13276 373384003083 Integrase core domain; Region: rve; pfam00665 373384003084 Integrase core domain; Region: rve_3; pfam13683 373384003085 Transposase; Region: HTH_Tnp_1; cl17663 373384003086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003087 putative transposase OrfB; Reviewed; Region: PHA02517 373384003088 Integrase core domain; Region: rve; pfam00665 373384003089 Integrase core domain; Region: rve_3; pfam13683 373384003090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003091 Transposase; Region: HTH_Tnp_1; pfam01527 373384003092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384003093 Integrase core domain; Region: rve; pfam00665 373384003094 Integrase core domain; Region: rve_3; pfam13683 373384003095 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 373384003096 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 373384003097 catalytic residues [active] 373384003098 catalytic nucleophile [active] 373384003099 Recombinase; Region: Recombinase; pfam07508 373384003100 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 373384003101 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 373384003102 putative acyl-acceptor binding pocket; other site 373384003103 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 373384003104 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 373384003105 active site residue [active] 373384003106 hypothetical protein; Provisional; Region: PRK03757 373384003107 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 373384003108 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 373384003109 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 373384003110 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373384003111 DNA damage-inducible protein I; Provisional; Region: PRK10597 373384003112 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 373384003113 active site 373384003114 substrate binding pocket [chemical binding]; other site 373384003115 dimer interface [polypeptide binding]; other site 373384003116 lipoprotein; Provisional; Region: PRK10598 373384003117 glutaredoxin 2; Provisional; Region: PRK10387 373384003118 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 373384003119 C-terminal domain interface [polypeptide binding]; other site 373384003120 GSH binding site (G-site) [chemical binding]; other site 373384003121 catalytic residues [active] 373384003122 putative dimer interface [polypeptide binding]; other site 373384003123 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 373384003124 N-terminal domain interface [polypeptide binding]; other site 373384003125 multidrug resistance protein MdtH; Provisional; Region: PRK11646 373384003126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384003127 putative substrate translocation pore; other site 373384003128 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 373384003129 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 373384003130 hypothetical protein; Provisional; Region: PRK11239 373384003131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 373384003132 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373384003133 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373384003134 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 373384003135 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 373384003136 MviN-like protein; Region: MVIN; pfam03023 373384003137 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 373384003138 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 373384003139 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 373384003140 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 373384003141 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 373384003142 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 373384003143 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 373384003144 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 373384003145 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 373384003146 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 373384003147 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 373384003148 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 373384003149 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 373384003150 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 373384003151 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 373384003152 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 373384003153 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 373384003154 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 373384003155 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 373384003156 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 373384003157 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 373384003158 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 373384003159 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 373384003160 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 373384003161 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 373384003162 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 373384003163 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 373384003164 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 373384003165 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 373384003166 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 373384003167 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 373384003168 homodimer interface [polypeptide binding]; other site 373384003169 oligonucleotide binding site [chemical binding]; other site 373384003170 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 373384003171 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 373384003172 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384003173 RNA binding surface [nucleotide binding]; other site 373384003174 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 373384003175 active site 373384003176 Maf-like protein; Region: Maf; pfam02545 373384003177 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 373384003178 active site 373384003179 dimer interface [polypeptide binding]; other site 373384003180 hypothetical protein; Provisional; Region: PRK11193 373384003181 putative phosphate acyltransferase; Provisional; Region: PRK05331 373384003182 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 373384003183 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 373384003184 dimer interface [polypeptide binding]; other site 373384003185 active site 373384003186 CoA binding pocket [chemical binding]; other site 373384003187 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 373384003188 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 373384003189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 373384003190 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 373384003191 NAD(P) binding site [chemical binding]; other site 373384003192 homotetramer interface [polypeptide binding]; other site 373384003193 homodimer interface [polypeptide binding]; other site 373384003194 active site 373384003195 acyl carrier protein; Provisional; Region: acpP; PRK00982 373384003196 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 373384003197 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 373384003198 dimer interface [polypeptide binding]; other site 373384003199 active site 373384003200 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 373384003201 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 373384003202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384003203 catalytic residue [active] 373384003204 conserved hypothetical protein, YceG family; Region: TIGR00247 373384003205 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 373384003206 dimerization interface [polypeptide binding]; other site 373384003207 thymidylate kinase; Validated; Region: tmk; PRK00698 373384003208 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 373384003209 TMP-binding site; other site 373384003210 ATP-binding site [chemical binding]; other site 373384003211 DNA polymerase III subunit delta'; Validated; Region: PRK07993 373384003212 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 373384003213 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 373384003214 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 373384003215 active site 373384003216 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 373384003217 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 373384003218 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 373384003219 active site turn [active] 373384003220 phosphorylation site [posttranslational modification] 373384003221 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 373384003222 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373384003223 N-terminal plug; other site 373384003224 ligand-binding site [chemical binding]; other site 373384003225 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 373384003226 nucleotide binding site/active site [active] 373384003227 HIT family signature motif; other site 373384003228 catalytic residue [active] 373384003229 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 373384003230 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 373384003231 putative dimer interface [polypeptide binding]; other site 373384003232 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 373384003233 thiamine kinase; Region: ycfN_thiK; TIGR02721 373384003234 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 373384003235 active site 373384003236 substrate binding site [chemical binding]; other site 373384003237 ATP binding site [chemical binding]; other site 373384003238 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 373384003239 beta-hexosaminidase; Provisional; Region: PRK05337 373384003240 hypothetical protein; Provisional; Region: PRK04940 373384003241 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 373384003242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384003243 hypothetical protein; Provisional; Region: PRK11280 373384003244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373384003245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384003246 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 373384003247 L,D-transpeptidase; Provisional; Region: PRK10260 373384003248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384003249 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373384003250 transcription-repair coupling factor; Provisional; Region: PRK10689 373384003251 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 373384003252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384003253 ATP binding site [chemical binding]; other site 373384003254 putative Mg++ binding site [ion binding]; other site 373384003255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384003256 nucleotide binding region [chemical binding]; other site 373384003257 ATP-binding site [chemical binding]; other site 373384003258 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 373384003259 Predicted membrane protein [Function unknown]; Region: COG4763 373384003260 Acyltransferase family; Region: Acyl_transf_3; pfam01757 373384003261 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 373384003262 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373384003263 FtsX-like permease family; Region: FtsX; pfam02687 373384003264 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 373384003265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 373384003266 Walker A/P-loop; other site 373384003267 ATP binding site [chemical binding]; other site 373384003268 Q-loop/lid; other site 373384003269 ABC transporter signature motif; other site 373384003270 Walker B; other site 373384003271 D-loop; other site 373384003272 H-loop/switch region; other site 373384003273 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 373384003274 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 373384003275 FtsX-like permease family; Region: FtsX; pfam02687 373384003276 fructokinase; Reviewed; Region: PRK09557 373384003277 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373384003278 nucleotide binding site [chemical binding]; other site 373384003279 NAD-dependent deacetylase; Provisional; Region: PRK00481 373384003280 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 373384003281 NAD+ binding site [chemical binding]; other site 373384003282 substrate binding site [chemical binding]; other site 373384003283 Zn binding site [ion binding]; other site 373384003284 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 373384003285 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 373384003286 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 373384003287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003288 dimer interface [polypeptide binding]; other site 373384003289 conserved gate region; other site 373384003290 putative PBP binding loops; other site 373384003291 ABC-ATPase subunit interface; other site 373384003292 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 373384003293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003294 dimer interface [polypeptide binding]; other site 373384003295 conserved gate region; other site 373384003296 putative PBP binding loops; other site 373384003297 ABC-ATPase subunit interface; other site 373384003298 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 373384003299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384003300 Walker A/P-loop; other site 373384003301 ATP binding site [chemical binding]; other site 373384003302 Q-loop/lid; other site 373384003303 ABC transporter signature motif; other site 373384003304 Walker B; other site 373384003305 D-loop; other site 373384003306 H-loop/switch region; other site 373384003307 TOBE domain; Region: TOBE_2; pfam08402 373384003308 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 373384003309 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 373384003310 metal binding site [ion binding]; metal-binding site 373384003311 dimer interface [polypeptide binding]; other site 373384003312 Uncharacterized conserved protein [Function unknown]; Region: COG2850 373384003313 Cupin-like domain; Region: Cupin_8; pfam13621 373384003314 integrase; Provisional; Region: PRK09692 373384003315 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 373384003316 active site 373384003317 Int/Topo IB signature motif; other site 373384003318 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 373384003319 D5 N terminal like; Region: D5_N; smart00885 373384003320 Phage associated DNA primase [General function prediction only]; Region: COG3378 373384003321 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 373384003322 PerC transcriptional activator; Region: PerC; pfam06069 373384003323 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384003324 Phage head maturation protease [General function prediction only]; Region: COG3740 373384003325 Phage-related protein [Function unknown]; Region: COG4695 373384003326 Phage portal protein; Region: Phage_portal; pfam04860 373384003327 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 373384003328 oligomerization interface [polypeptide binding]; other site 373384003329 Phage terminase, small subunit; Region: Terminase_4; cl01525 373384003330 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 373384003331 sensor protein PhoQ; Provisional; Region: PRK10815 373384003332 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 373384003333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 373384003334 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 373384003335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384003336 ATP binding site [chemical binding]; other site 373384003337 Mg2+ binding site [ion binding]; other site 373384003338 G-X-G motif; other site 373384003339 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 373384003340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384003341 active site 373384003342 phosphorylation site [posttranslational modification] 373384003343 intermolecular recognition site; other site 373384003344 dimerization interface [polypeptide binding]; other site 373384003345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384003346 DNA binding site [nucleotide binding] 373384003347 adenylosuccinate lyase; Provisional; Region: PRK09285 373384003348 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 373384003349 tetramer interface [polypeptide binding]; other site 373384003350 active site 373384003351 putative lysogenization regulator; Reviewed; Region: PRK00218 373384003352 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 373384003353 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 373384003354 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 373384003355 nudix motif; other site 373384003356 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 373384003357 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 373384003358 probable active site [active] 373384003359 isocitrate dehydrogenase; Validated; Region: PRK07362 373384003360 isocitrate dehydrogenase; Reviewed; Region: PRK07006 373384003361 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384003362 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 373384003363 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 373384003364 Autotransporter beta-domain; Region: Autotransporter; pfam03797 373384003365 Autotransporter beta-domain; Region: Autotransporter; smart00869 373384003366 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 373384003367 cell division inhibitor MinD; Provisional; Region: PRK10818 373384003368 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 373384003369 Switch I; other site 373384003370 Switch II; other site 373384003371 septum formation inhibitor; Reviewed; Region: minC; PRK03511 373384003372 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 373384003373 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 373384003374 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384003375 HTH-like domain; Region: HTH_21; pfam13276 373384003376 Integrase core domain; Region: rve; pfam00665 373384003377 Integrase core domain; Region: rve_3; pfam13683 373384003378 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384003379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003380 Transposase; Region: HTH_Tnp_1; cl17663 373384003381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003382 putative transposase OrfB; Reviewed; Region: PHA02517 373384003383 HTH-like domain; Region: HTH_21; pfam13276 373384003384 Integrase core domain; Region: rve; pfam00665 373384003385 Integrase core domain; Region: rve_2; pfam13333 373384003386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 373384003387 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 373384003388 hypothetical protein; Provisional; Region: PRK10691 373384003389 hypothetical protein; Provisional; Region: PRK05170 373384003390 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 373384003391 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 373384003392 Catalytic site [active] 373384003393 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 373384003394 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 373384003395 active site 373384003396 DNA binding site [nucleotide binding] 373384003397 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 373384003398 disulfide bond formation protein B; Provisional; Region: PRK01749 373384003399 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 373384003400 transmembrane helices; other site 373384003401 fatty acid metabolism regulator; Provisional; Region: PRK04984 373384003402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384003403 DNA-binding site [nucleotide binding]; DNA binding site 373384003404 FadR C-terminal domain; Region: FadR_C; pfam07840 373384003405 SpoVR family protein; Provisional; Region: PRK11767 373384003406 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 373384003407 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 373384003408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384003409 alanine racemase; Reviewed; Region: dadX; PRK03646 373384003410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 373384003411 active site 373384003412 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373384003413 substrate binding site [chemical binding]; other site 373384003414 catalytic residues [active] 373384003415 dimer interface [polypeptide binding]; other site 373384003416 Leucine rich repeat; Region: LRR_8; pfam13855 373384003417 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 373384003418 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 373384003419 TrkA-C domain; Region: TrkA_C; pfam02080 373384003420 Transporter associated domain; Region: CorC_HlyC; smart01091 373384003421 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 373384003422 dimer interface [polypeptide binding]; other site 373384003423 catalytic triad [active] 373384003424 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 373384003425 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373384003426 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373384003427 catalytic residue [active] 373384003428 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 373384003429 Flagellar regulator YcgR; Region: YcgR; pfam07317 373384003430 PilZ domain; Region: PilZ; pfam07238 373384003431 hypothetical protein; Provisional; Region: PRK10457 373384003432 molybdenum transport protein ModD; Provisional; Region: PRK06096 373384003433 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 373384003434 dimerization interface [polypeptide binding]; other site 373384003435 active site 373384003436 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373384003437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384003438 S-adenosylmethionine binding site [chemical binding]; other site 373384003439 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 373384003440 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 373384003441 Walker A/P-loop; other site 373384003442 ATP binding site [chemical binding]; other site 373384003443 Q-loop/lid; other site 373384003444 ABC transporter signature motif; other site 373384003445 Walker B; other site 373384003446 D-loop; other site 373384003447 H-loop/switch region; other site 373384003448 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 373384003449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384003450 ABC-ATPase subunit interface; other site 373384003451 dimer interface [polypeptide binding]; other site 373384003452 putative PBP binding regions; other site 373384003453 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 373384003454 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 373384003455 putative metal binding site [ion binding]; other site 373384003456 trehalase; Provisional; Region: treA; PRK13271 373384003457 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 373384003458 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 373384003459 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 373384003460 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373384003461 dimerization domain swap beta strand [polypeptide binding]; other site 373384003462 regulatory protein interface [polypeptide binding]; other site 373384003463 active site 373384003464 regulatory phosphorylation site [posttranslational modification]; other site 373384003465 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 373384003466 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373384003467 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 373384003468 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 373384003469 Dak1 domain; Region: Dak1; pfam02733 373384003470 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 373384003471 PAS domain; Region: PAS; smart00091 373384003472 putative active site [active] 373384003473 heme pocket [chemical binding]; other site 373384003474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384003475 Walker A motif; other site 373384003476 ATP binding site [chemical binding]; other site 373384003477 Walker B motif; other site 373384003478 arginine finger; other site 373384003479 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 373384003480 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 373384003481 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 373384003482 Autotransporter beta-domain; Region: Autotransporter; pfam03797 373384003483 GTP-binding protein YchF; Reviewed; Region: PRK09601 373384003484 YchF GTPase; Region: YchF; cd01900 373384003485 G1 box; other site 373384003486 GTP/Mg2+ binding site [chemical binding]; other site 373384003487 Switch I region; other site 373384003488 G2 box; other site 373384003489 Switch II region; other site 373384003490 G3 box; other site 373384003491 G4 box; other site 373384003492 G5 box; other site 373384003493 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 373384003494 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 373384003495 putative active site [active] 373384003496 catalytic residue [active] 373384003497 hypothetical protein; Provisional; Region: PRK10692 373384003498 putative transporter; Provisional; Region: PRK11660 373384003499 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 373384003500 Sulfate transporter family; Region: Sulfate_transp; pfam00916 373384003501 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 373384003502 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 373384003503 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 373384003504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384003505 active site 373384003506 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 373384003507 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 373384003508 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 373384003509 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 373384003510 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 373384003511 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 373384003512 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 373384003513 tRNA; other site 373384003514 putative tRNA binding site [nucleotide binding]; other site 373384003515 putative NADP binding site [chemical binding]; other site 373384003516 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 373384003517 peptide chain release factor 1; Validated; Region: prfA; PRK00591 373384003518 This domain is found in peptide chain release factors; Region: PCRF; smart00937 373384003519 RF-1 domain; Region: RF-1; pfam00472 373384003520 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 373384003521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384003522 hypothetical protein; Provisional; Region: PRK10278 373384003523 hypothetical protein; Provisional; Region: PRK10941 373384003524 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 373384003525 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 373384003526 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 373384003527 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384003528 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384003529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384003530 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 373384003531 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 373384003532 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373384003533 cation transport regulator; Reviewed; Region: chaB; PRK09582 373384003534 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 373384003535 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 373384003536 putative active site pocket [active] 373384003537 dimerization interface [polypeptide binding]; other site 373384003538 putative catalytic residue [active] 373384003539 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 373384003540 putative invasin; Provisional; Region: PRK10177 373384003541 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 373384003542 transcriptional regulator NarL; Provisional; Region: PRK10651 373384003543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384003544 active site 373384003545 phosphorylation site [posttranslational modification] 373384003546 intermolecular recognition site; other site 373384003547 dimerization interface [polypeptide binding]; other site 373384003548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384003549 DNA binding residues [nucleotide binding] 373384003550 dimerization interface [polypeptide binding]; other site 373384003551 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 373384003552 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 373384003553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384003554 dimerization interface [polypeptide binding]; other site 373384003555 Histidine kinase; Region: HisKA_3; pfam07730 373384003556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384003557 ATP binding site [chemical binding]; other site 373384003558 Mg2+ binding site [ion binding]; other site 373384003559 G-X-G motif; other site 373384003560 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 373384003561 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 373384003562 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 373384003563 [4Fe-4S] binding site [ion binding]; other site 373384003564 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384003565 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384003566 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384003567 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 373384003568 molybdopterin cofactor binding site; other site 373384003569 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 373384003570 4Fe-4S binding domain; Region: Fer4; cl02805 373384003571 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 373384003572 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 373384003573 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 373384003574 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 373384003575 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 373384003576 putative active site [active] 373384003577 putative substrate binding site [chemical binding]; other site 373384003578 putative cosubstrate binding site; other site 373384003579 catalytic site [active] 373384003580 SEC-C motif; Region: SEC-C; pfam02810 373384003581 hypothetical protein; Provisional; Region: PRK04233 373384003582 hypothetical protein; Provisional; Region: PRK10279 373384003583 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 373384003584 active site 373384003585 nucleophile elbow; other site 373384003586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384003587 active site 373384003588 response regulator of RpoS; Provisional; Region: PRK10693 373384003589 phosphorylation site [posttranslational modification] 373384003590 intermolecular recognition site; other site 373384003591 dimerization interface [polypeptide binding]; other site 373384003592 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 373384003593 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 373384003594 active site 373384003595 tetramer interface; other site 373384003596 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 373384003597 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 373384003598 thymidine kinase; Provisional; Region: PRK04296 373384003599 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384003600 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384003601 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384003602 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 373384003603 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 373384003604 putative catalytic cysteine [active] 373384003605 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 373384003606 putative active site [active] 373384003607 metal binding site [ion binding]; metal-binding site 373384003608 hypothetical protein; Provisional; Region: PRK11111 373384003609 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 373384003610 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 373384003611 peptide binding site [polypeptide binding]; other site 373384003612 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 373384003613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003614 dimer interface [polypeptide binding]; other site 373384003615 conserved gate region; other site 373384003616 putative PBP binding loops; other site 373384003617 ABC-ATPase subunit interface; other site 373384003618 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 373384003619 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 373384003620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003621 dimer interface [polypeptide binding]; other site 373384003622 conserved gate region; other site 373384003623 putative PBP binding loops; other site 373384003624 ABC-ATPase subunit interface; other site 373384003625 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 373384003626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384003627 Walker A/P-loop; other site 373384003628 ATP binding site [chemical binding]; other site 373384003629 Q-loop/lid; other site 373384003630 ABC transporter signature motif; other site 373384003631 Walker B; other site 373384003632 D-loop; other site 373384003633 H-loop/switch region; other site 373384003634 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 373384003635 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 373384003636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384003637 Walker A/P-loop; other site 373384003638 ATP binding site [chemical binding]; other site 373384003639 Q-loop/lid; other site 373384003640 ABC transporter signature motif; other site 373384003641 Walker B; other site 373384003642 D-loop; other site 373384003643 H-loop/switch region; other site 373384003644 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 373384003645 dsDNA-mimic protein; Reviewed; Region: PRK05094 373384003646 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 373384003647 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 373384003648 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 373384003649 putative active site [active] 373384003650 catalytic site [active] 373384003651 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 373384003652 putative active site [active] 373384003653 catalytic site [active] 373384003654 voltage-gated potassium channel; Provisional; Region: PRK10537 373384003655 Ion channel; Region: Ion_trans_2; pfam07885 373384003656 TrkA-N domain; Region: TrkA_N; pfam02254 373384003657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003658 Transposase; Region: HTH_Tnp_1; pfam01527 373384003659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384003660 Integrase core domain; Region: rve; pfam00665 373384003661 Integrase core domain; Region: rve_3; pfam13683 373384003662 YciI-like protein; Reviewed; Region: PRK11370 373384003663 transport protein TonB; Provisional; Region: PRK10819 373384003664 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 373384003665 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 373384003666 intracellular septation protein A; Reviewed; Region: PRK00259 373384003667 hypothetical protein; Provisional; Region: PRK02868 373384003668 outer membrane protein W; Provisional; Region: PRK10959 373384003669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 373384003670 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 373384003671 dimerization interface [polypeptide binding]; other site 373384003672 metal binding site [ion binding]; metal-binding site 373384003673 General stress protein [General function prediction only]; Region: GsiB; COG3729 373384003674 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 373384003675 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 373384003676 substrate binding site [chemical binding]; other site 373384003677 active site 373384003678 catalytic residues [active] 373384003679 heterodimer interface [polypeptide binding]; other site 373384003680 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 373384003681 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 373384003682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384003683 catalytic residue [active] 373384003684 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 373384003685 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 373384003686 active site 373384003687 ribulose/triose binding site [chemical binding]; other site 373384003688 phosphate binding site [ion binding]; other site 373384003689 substrate (anthranilate) binding pocket [chemical binding]; other site 373384003690 product (indole) binding pocket [chemical binding]; other site 373384003691 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 373384003692 active site 373384003693 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 373384003694 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 373384003695 glutamine binding [chemical binding]; other site 373384003696 catalytic triad [active] 373384003697 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 373384003698 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 373384003699 anthranilate synthase component I; Provisional; Region: PRK13564 373384003700 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 373384003701 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 373384003702 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 373384003703 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 373384003704 active site 373384003705 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 373384003706 hypothetical protein; Provisional; Region: PRK11630 373384003707 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 373384003708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384003709 RNA binding surface [nucleotide binding]; other site 373384003710 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 373384003711 probable active site [active] 373384003712 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 373384003713 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 373384003714 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 373384003715 homodimer interface [polypeptide binding]; other site 373384003716 Walker A motif; other site 373384003717 ATP binding site [chemical binding]; other site 373384003718 hydroxycobalamin binding site [chemical binding]; other site 373384003719 Walker B motif; other site 373384003720 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 373384003721 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 373384003722 NADP binding site [chemical binding]; other site 373384003723 homodimer interface [polypeptide binding]; other site 373384003724 active site 373384003725 putative inner membrane peptidase; Provisional; Region: PRK11778 373384003726 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 373384003727 tandem repeat interface [polypeptide binding]; other site 373384003728 oligomer interface [polypeptide binding]; other site 373384003729 active site residues [active] 373384003730 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 373384003731 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 373384003732 active site 373384003733 interdomain interaction site; other site 373384003734 putative metal-binding site [ion binding]; other site 373384003735 nucleotide binding site [chemical binding]; other site 373384003736 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 373384003737 domain I; other site 373384003738 DNA binding groove [nucleotide binding] 373384003739 phosphate binding site [ion binding]; other site 373384003740 domain II; other site 373384003741 domain III; other site 373384003742 nucleotide binding site [chemical binding]; other site 373384003743 catalytic site [active] 373384003744 domain IV; other site 373384003745 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 373384003746 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 373384003747 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 373384003748 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 373384003749 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 373384003750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384003751 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 373384003752 substrate binding site [chemical binding]; other site 373384003753 putative dimerization interface [polypeptide binding]; other site 373384003754 aconitate hydratase; Validated; Region: PRK09277 373384003755 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 373384003756 substrate binding site [chemical binding]; other site 373384003757 ligand binding site [chemical binding]; other site 373384003758 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 373384003759 substrate binding site [chemical binding]; other site 373384003760 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 373384003761 dimerization interface [polypeptide binding]; other site 373384003762 active site 373384003763 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 373384003764 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 373384003765 active site 373384003766 Predicted membrane protein [Function unknown]; Region: COG3771 373384003767 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 373384003768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373384003769 TPR motif; other site 373384003770 binding surface 373384003771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373384003772 binding surface 373384003773 TPR motif; other site 373384003774 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 373384003775 active site 373384003776 dimer interface [polypeptide binding]; other site 373384003777 translation initiation factor Sui1; Validated; Region: PRK06824 373384003778 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 373384003779 putative rRNA binding site [nucleotide binding]; other site 373384003780 lipoprotein; Provisional; Region: PRK10540 373384003781 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 373384003782 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 373384003783 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384003784 hypothetical protein; Provisional; Region: PRK13658 373384003785 exoribonuclease II; Provisional; Region: PRK05054 373384003786 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 373384003787 RNB domain; Region: RNB; pfam00773 373384003788 S1 RNA binding domain; Region: S1; pfam00575 373384003789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 373384003790 Uncharacterized conserved protein [Function unknown]; Region: COG2128 373384003791 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 373384003792 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 373384003793 NAD binding site [chemical binding]; other site 373384003794 homotetramer interface [polypeptide binding]; other site 373384003795 homodimer interface [polypeptide binding]; other site 373384003796 substrate binding site [chemical binding]; other site 373384003797 active site 373384003798 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 373384003799 putative active site [active] 373384003800 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 373384003801 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384003802 Walker A/P-loop; other site 373384003803 ATP binding site [chemical binding]; other site 373384003804 Q-loop/lid; other site 373384003805 ABC transporter signature motif; other site 373384003806 Walker B; other site 373384003807 D-loop; other site 373384003808 H-loop/switch region; other site 373384003809 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 373384003810 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384003811 Walker A/P-loop; other site 373384003812 ATP binding site [chemical binding]; other site 373384003813 Q-loop/lid; other site 373384003814 ABC transporter signature motif; other site 373384003815 Walker B; other site 373384003816 D-loop; other site 373384003817 H-loop/switch region; other site 373384003818 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373384003819 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 373384003820 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 373384003821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003822 dimer interface [polypeptide binding]; other site 373384003823 conserved gate region; other site 373384003824 putative PBP binding loops; other site 373384003825 ABC-ATPase subunit interface; other site 373384003826 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 373384003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003828 dimer interface [polypeptide binding]; other site 373384003829 conserved gate region; other site 373384003830 putative PBP binding loops; other site 373384003831 ABC-ATPase subunit interface; other site 373384003832 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 373384003833 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 373384003834 peptide binding site [polypeptide binding]; other site 373384003835 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 373384003836 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 373384003837 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 373384003838 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 373384003839 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 373384003840 catalytic triad [active] 373384003841 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 373384003842 Cupin domain; Region: Cupin_2; pfam07883 373384003843 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 373384003844 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 373384003845 NAD(P) binding site [chemical binding]; other site 373384003846 catalytic residues [active] 373384003847 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 373384003848 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 373384003849 4-aminobutyrate transaminase; Provisional; Region: PRK09792 373384003850 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373384003851 inhibitor-cofactor binding pocket; inhibition site 373384003852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384003853 catalytic residue [active] 373384003854 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 373384003855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384003856 Walker A motif; other site 373384003857 ATP binding site [chemical binding]; other site 373384003858 Walker B motif; other site 373384003859 arginine finger; other site 373384003860 phage shock protein PspA; Provisional; Region: PRK10698 373384003861 phage shock protein B; Provisional; Region: pspB; PRK09458 373384003862 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 373384003863 phage shock protein C; Region: phageshock_pspC; TIGR02978 373384003864 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 373384003865 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373384003866 active site residue [active] 373384003867 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384003868 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 373384003869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003870 dimer interface [polypeptide binding]; other site 373384003871 conserved gate region; other site 373384003872 putative PBP binding loops; other site 373384003873 ABC-ATPase subunit interface; other site 373384003874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373384003875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384003876 dimer interface [polypeptide binding]; other site 373384003877 conserved gate region; other site 373384003878 putative PBP binding loops; other site 373384003879 ABC-ATPase subunit interface; other site 373384003880 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373384003881 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 373384003882 putative NAD(P) binding site [chemical binding]; other site 373384003883 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 373384003884 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 373384003885 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 373384003886 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 373384003887 beta-phosphoglucomutase; Region: bPGM; TIGR01990 373384003888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384003889 motif II; other site 373384003890 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 373384003891 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 373384003892 Walker A/P-loop; other site 373384003893 ATP binding site [chemical binding]; other site 373384003894 Q-loop/lid; other site 373384003895 ABC transporter signature motif; other site 373384003896 Walker B; other site 373384003897 D-loop; other site 373384003898 H-loop/switch region; other site 373384003899 TOBE domain; Region: TOBE_2; pfam08402 373384003900 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373384003901 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384003902 DNA binding site [nucleotide binding] 373384003903 domain linker motif; other site 373384003904 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 373384003905 putative dimerization interface [polypeptide binding]; other site 373384003906 putative ligand binding site [chemical binding]; other site 373384003907 Predicted ATPase [General function prediction only]; Region: COG3106 373384003908 Predicted membrane protein [Function unknown]; Region: COG3768 373384003909 TIGR01620 family protein; Region: hyp_HI0043 373384003910 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 373384003911 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 373384003912 putative aromatic amino acid binding site; other site 373384003913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384003914 Walker A motif; other site 373384003915 ATP binding site [chemical binding]; other site 373384003916 Walker B motif; other site 373384003917 arginine finger; other site 373384003918 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 373384003919 dimer interface [polypeptide binding]; other site 373384003920 catalytic triad [active] 373384003921 peroxidatic and resolving cysteines [active] 373384003922 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 373384003923 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 373384003924 active site 373384003925 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 373384003926 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 373384003927 putative active site [active] 373384003928 Zn binding site [ion binding]; other site 373384003929 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 373384003930 NADH(P)-binding; Region: NAD_binding_10; pfam13460 373384003931 putative NAD(P) binding site [chemical binding]; other site 373384003932 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 373384003933 Transposase; Region: DEDD_Tnp_IS110; pfam01548 373384003934 Y-family of DNA polymerases; Region: PolY; cl12025 373384003935 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 373384003936 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 373384003937 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373384003938 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 373384003939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373384003940 Erv1 / Alr family; Region: Evr1_Alr; cl02107 373384003941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384003942 Integrase core domain; Region: rve; pfam00665 373384003943 Integrase core domain; Region: rve_3; pfam13683 373384003944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003945 Transposase; Region: HTH_Tnp_1; pfam01527 373384003946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003947 Transposase; Region: HTH_Tnp_1; pfam01527 373384003948 Integrase core domain; Region: rve; pfam00665 373384003949 Integrase core domain; Region: rve_3; pfam13683 373384003950 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384003951 HTH-like domain; Region: HTH_21; pfam13276 373384003952 Integrase core domain; Region: rve; pfam00665 373384003953 Integrase core domain; Region: rve_3; pfam13683 373384003954 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384003955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003956 primosomal protein DnaI; Provisional; Region: PRK02854 373384003957 putative replication protein; Provisional; Region: PRK12377 373384003958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384003959 Walker A motif; other site 373384003960 ATP binding site [chemical binding]; other site 373384003961 Walker B motif; other site 373384003962 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 373384003963 Protein of unknown function (DUF551); Region: DUF551; pfam04448 373384003964 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384003965 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 373384003966 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 373384003967 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 373384003968 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 373384003969 Int/Topo IB signature motif; other site 373384003970 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384003971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384003972 Integrase core domain; Region: rve; pfam00665 373384003973 Integrase core domain; Region: rve_3; pfam13683 373384003974 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 373384003975 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 373384003976 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384003977 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 373384003978 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384003979 ABC-ATPase subunit interface; other site 373384003980 dimer interface [polypeptide binding]; other site 373384003981 putative PBP binding regions; other site 373384003982 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 373384003983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384003984 putative PBP binding regions; other site 373384003985 ABC-ATPase subunit interface; other site 373384003986 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 373384003987 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 373384003988 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 373384003989 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 373384003990 metal binding site [ion binding]; metal-binding site 373384003991 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 373384003992 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 373384003993 Int/Topo IB signature motif; other site 373384003994 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384003995 Homeodomain-like domain; Region: HTH_23; pfam13384 373384003996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384003997 Transposase; Region: HTH_Tnp_1; pfam01527 373384003998 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384003999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384004000 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 373384004001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384004002 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 373384004003 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 373384004004 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 373384004005 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384004006 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 373384004007 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373384004008 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 373384004009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004010 Transposase; Region: HTH_Tnp_1; pfam01527 373384004011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384004012 Integrase core domain; Region: rve; pfam00665 373384004013 Integrase core domain; Region: rve_3; pfam13683 373384004014 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 373384004015 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 373384004016 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 373384004017 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 373384004018 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 373384004019 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 373384004020 mce related protein; Region: MCE; pfam02470 373384004021 mce related protein; Region: MCE; pfam02470 373384004022 mce related protein; Region: MCE; pfam02470 373384004023 mce related protein; Region: MCE; pfam02470 373384004024 mce related protein; Region: MCE; pfam02470 373384004025 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 373384004026 Paraquat-inducible protein A; Region: PqiA; pfam04403 373384004027 Paraquat-inducible protein A; Region: PqiA; pfam04403 373384004028 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 373384004029 GAF domain; Region: GAF_2; pfam13185 373384004030 ProP expression regulator; Provisional; Region: PRK04950 373384004031 ProQ/FINO family; Region: ProQ; pfam04352 373384004032 carboxy-terminal protease; Provisional; Region: PRK11186 373384004033 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 373384004034 protein binding site [polypeptide binding]; other site 373384004035 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 373384004036 Catalytic dyad [active] 373384004037 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 373384004038 heat shock protein HtpX; Provisional; Region: PRK05457 373384004039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384004041 putative substrate translocation pore; other site 373384004042 Predicted integral membrane protein [Function unknown]; Region: COG5521 373384004043 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 373384004044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384004045 dimerization interface [polypeptide binding]; other site 373384004046 putative Zn2+ binding site [ion binding]; other site 373384004047 putative DNA binding site [nucleotide binding]; other site 373384004048 Bacterial transcriptional regulator; Region: IclR; pfam01614 373384004049 PhoPQ regulatory protein; Provisional; Region: PRK10299 373384004050 YebO-like protein; Region: YebO; pfam13974 373384004051 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 373384004052 DNA-binding site [nucleotide binding]; DNA binding site 373384004053 RNA-binding motif; other site 373384004054 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 373384004055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384004056 S-adenosylmethionine binding site [chemical binding]; other site 373384004057 hypothetical protein; Provisional; Region: PRK11469 373384004058 Domain of unknown function DUF; Region: DUF204; pfam02659 373384004059 Domain of unknown function DUF; Region: DUF204; pfam02659 373384004060 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004061 Predicted membrane protein [Function unknown]; Region: COG4811 373384004062 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 373384004063 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 373384004064 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 373384004065 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 373384004066 active pocket/dimerization site; other site 373384004067 active site 373384004068 phosphorylation site [posttranslational modification] 373384004069 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 373384004070 active site 373384004071 phosphorylation site [posttranslational modification] 373384004072 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 373384004073 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 373384004074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373384004075 Transporter associated domain; Region: CorC_HlyC; smart01091 373384004076 phage resistance protein; Provisional; Region: PRK10551 373384004077 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 373384004078 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384004079 L-serine deaminase; Provisional; Region: PRK15023 373384004080 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 373384004081 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 373384004082 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 373384004083 putative active site [active] 373384004084 putative CoA binding site [chemical binding]; other site 373384004085 nudix motif; other site 373384004086 metal binding site [ion binding]; metal-binding site 373384004087 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 373384004088 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 373384004089 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 373384004090 hypothetical protein; Provisional; Region: PRK05114 373384004091 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 373384004092 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 373384004093 homotrimer interaction site [polypeptide binding]; other site 373384004094 putative active site [active] 373384004095 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 373384004096 DEAD/DEAH box helicase; Region: DEAD; pfam00270 373384004097 DEAD_2; Region: DEAD_2; pfam06733 373384004098 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 373384004099 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 373384004100 Glycoprotease family; Region: Peptidase_M22; pfam00814 373384004101 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 373384004102 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 373384004103 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 373384004104 acyl-activating enzyme (AAE) consensus motif; other site 373384004105 putative AMP binding site [chemical binding]; other site 373384004106 putative active site [active] 373384004107 putative CoA binding site [chemical binding]; other site 373384004108 ribonuclease D; Provisional; Region: PRK10829 373384004109 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 373384004110 catalytic site [active] 373384004111 putative active site [active] 373384004112 putative substrate binding site [chemical binding]; other site 373384004113 Helicase and RNase D C-terminal; Region: HRDC; smart00341 373384004114 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 373384004115 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 373384004116 FMN-binding pocket [chemical binding]; other site 373384004117 flavin binding motif; other site 373384004118 phosphate binding motif [ion binding]; other site 373384004119 beta-alpha-beta structure motif; other site 373384004120 NAD binding pocket [chemical binding]; other site 373384004121 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373384004122 catalytic loop [active] 373384004123 iron binding site [ion binding]; other site 373384004124 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373384004125 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 373384004126 putative alpha subunit interface [polypeptide binding]; other site 373384004127 putative active site [active] 373384004128 putative substrate binding site [chemical binding]; other site 373384004129 Fe binding site [ion binding]; other site 373384004130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004131 Transposase; Region: HTH_Tnp_1; pfam01527 373384004132 HTH-like domain; Region: HTH_21; pfam13276 373384004133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384004134 Integrase core domain; Region: rve; pfam00665 373384004135 Integrase core domain; Region: rve_3; pfam13683 373384004136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 373384004137 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373384004138 Walker A motif; other site 373384004139 ATP binding site [chemical binding]; other site 373384004140 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004141 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 373384004142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384004143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384004144 active site 373384004145 catalytic tetrad [active] 373384004146 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 373384004147 active site 373384004148 phosphate binding residues; other site 373384004149 catalytic residues [active] 373384004150 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 373384004151 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 373384004152 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 373384004153 methionine sulfoxide reductase B; Provisional; Region: PRK00222 373384004154 SelR domain; Region: SelR; pfam01641 373384004155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 373384004156 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373384004157 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 373384004158 putative NAD(P) binding site [chemical binding]; other site 373384004159 catalytic Zn binding site [ion binding]; other site 373384004160 structural Zn binding site [ion binding]; other site 373384004161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004162 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 373384004163 intersubunit interface [polypeptide binding]; other site 373384004164 active site 373384004165 zinc binding site [ion binding]; other site 373384004166 Na+ binding site [ion binding]; other site 373384004167 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384004168 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 373384004169 substrate binding site [chemical binding]; other site 373384004170 ATP binding site [chemical binding]; other site 373384004171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384004172 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384004173 active site 373384004174 catalytic tetrad [active] 373384004175 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 373384004176 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 373384004177 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384004178 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004179 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 373384004180 Isochorismatase family; Region: Isochorismatase; pfam00857 373384004181 catalytic triad [active] 373384004182 metal binding site [ion binding]; metal-binding site 373384004183 conserved cis-peptide bond; other site 373384004184 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 373384004185 homodimer interface [polypeptide binding]; other site 373384004186 active site 373384004187 protease 4; Provisional; Region: PRK10949 373384004188 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 373384004189 tandem repeat interface [polypeptide binding]; other site 373384004190 oligomer interface [polypeptide binding]; other site 373384004191 active site residues [active] 373384004192 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 373384004193 tandem repeat interface [polypeptide binding]; other site 373384004194 oligomer interface [polypeptide binding]; other site 373384004195 active site residues [active] 373384004196 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 373384004197 putative FMN binding site [chemical binding]; other site 373384004198 selenophosphate synthetase; Provisional; Region: PRK00943 373384004199 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 373384004200 dimerization interface [polypeptide binding]; other site 373384004201 putative ATP binding site [chemical binding]; other site 373384004202 DNA topoisomerase III; Provisional; Region: PRK07726 373384004203 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 373384004204 active site 373384004205 putative interdomain interaction site [polypeptide binding]; other site 373384004206 putative metal-binding site [ion binding]; other site 373384004207 putative nucleotide binding site [chemical binding]; other site 373384004208 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 373384004209 domain I; other site 373384004210 DNA binding groove [nucleotide binding] 373384004211 phosphate binding site [ion binding]; other site 373384004212 domain II; other site 373384004213 domain III; other site 373384004214 nucleotide binding site [chemical binding]; other site 373384004215 catalytic site [active] 373384004216 domain IV; other site 373384004217 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 373384004218 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004219 glutamate dehydrogenase; Provisional; Region: PRK09414 373384004220 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 373384004221 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 373384004222 NAD(P) binding site [chemical binding]; other site 373384004223 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 373384004224 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 373384004225 active site 373384004226 8-oxo-dGMP binding site [chemical binding]; other site 373384004227 nudix motif; other site 373384004228 metal binding site [ion binding]; metal-binding site 373384004229 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 373384004230 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 373384004231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384004232 Walker A/P-loop; other site 373384004233 ATP binding site [chemical binding]; other site 373384004234 Q-loop/lid; other site 373384004235 ABC transporter signature motif; other site 373384004236 Walker B; other site 373384004237 D-loop; other site 373384004238 H-loop/switch region; other site 373384004239 hypothetical protein; Provisional; Region: PRK11622 373384004240 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384004241 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384004242 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384004243 hypothetical protein; Provisional; Region: PRK11622 373384004244 Uncharacterized conserved protein [Function unknown]; Region: COG2128 373384004245 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 373384004246 Uncharacterized conserved protein [Function unknown]; Region: COG0398 373384004247 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373384004248 Uncharacterized conserved protein [Function unknown]; Region: COG0398 373384004249 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373384004250 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 373384004251 putative catalytic site [active] 373384004252 putative phosphate binding site [ion binding]; other site 373384004253 active site 373384004254 metal binding site A [ion binding]; metal-binding site 373384004255 DNA binding site [nucleotide binding] 373384004256 putative AP binding site [nucleotide binding]; other site 373384004257 putative metal binding site B [ion binding]; other site 373384004258 arginine succinyltransferase; Provisional; Region: PRK10456 373384004259 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 373384004260 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 373384004261 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 373384004262 NAD(P) binding site [chemical binding]; other site 373384004263 catalytic residues [active] 373384004264 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 373384004265 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 373384004266 putative active site [active] 373384004267 Zn binding site [ion binding]; other site 373384004268 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 373384004269 dimer interface [polypeptide binding]; other site 373384004270 hypothetical protein; Provisional; Region: PRK11396 373384004271 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 373384004272 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 373384004273 GIY-YIG motif/motif A; other site 373384004274 active site 373384004275 catalytic site [active] 373384004276 putative DNA binding site [nucleotide binding]; other site 373384004277 metal binding site [ion binding]; metal-binding site 373384004278 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 373384004279 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 373384004280 homodimer interface [polypeptide binding]; other site 373384004281 NAD binding pocket [chemical binding]; other site 373384004282 ATP binding pocket [chemical binding]; other site 373384004283 Mg binding site [ion binding]; other site 373384004284 active-site loop [active] 373384004285 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 373384004286 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 373384004287 active site 373384004288 P-loop; other site 373384004289 phosphorylation site [posttranslational modification] 373384004290 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 373384004291 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 373384004292 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 373384004293 methionine cluster; other site 373384004294 active site 373384004295 phosphorylation site [posttranslational modification] 373384004296 metal binding site [ion binding]; metal-binding site 373384004297 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 373384004298 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 373384004299 NAD binding site [chemical binding]; other site 373384004300 sugar binding site [chemical binding]; other site 373384004301 divalent metal binding site [ion binding]; other site 373384004302 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373384004303 dimer interface [polypeptide binding]; other site 373384004304 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 373384004305 putative active site [active] 373384004306 YdjC motif; other site 373384004307 Mg binding site [ion binding]; other site 373384004308 putative homodimer interface [polypeptide binding]; other site 373384004309 hydroperoxidase II; Provisional; Region: katE; PRK11249 373384004310 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 373384004311 tetramer interface [polypeptide binding]; other site 373384004312 heme binding pocket [chemical binding]; other site 373384004313 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 373384004314 domain interactions; other site 373384004315 cell division modulator; Provisional; Region: PRK10113 373384004316 inner membrane protein; Provisional; Region: PRK11648 373384004317 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 373384004318 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 373384004319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384004320 motif II; other site 373384004321 YniB-like protein; Region: YniB; pfam14002 373384004322 Phosphotransferase enzyme family; Region: APH; pfam01636 373384004323 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 373384004324 active site 373384004325 ATP binding site [chemical binding]; other site 373384004326 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 373384004327 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 373384004328 6-phosphofructokinase 2; Provisional; Region: PRK10294 373384004329 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 373384004330 putative substrate binding site [chemical binding]; other site 373384004331 putative ATP binding site [chemical binding]; other site 373384004332 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 373384004333 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004334 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 373384004335 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 373384004336 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 373384004337 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 373384004338 active site 373384004339 dimer interface [polypeptide binding]; other site 373384004340 motif 1; other site 373384004341 motif 2; other site 373384004342 motif 3; other site 373384004343 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 373384004344 anticodon binding site; other site 373384004345 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 373384004346 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 373384004347 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 373384004348 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 373384004349 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 373384004350 23S rRNA binding site [nucleotide binding]; other site 373384004351 L21 binding site [polypeptide binding]; other site 373384004352 L13 binding site [polypeptide binding]; other site 373384004353 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 373384004354 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 373384004355 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 373384004356 dimer interface [polypeptide binding]; other site 373384004357 motif 1; other site 373384004358 active site 373384004359 motif 2; other site 373384004360 motif 3; other site 373384004361 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 373384004362 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 373384004363 putative tRNA-binding site [nucleotide binding]; other site 373384004364 B3/4 domain; Region: B3_4; pfam03483 373384004365 tRNA synthetase B5 domain; Region: B5; smart00874 373384004366 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 373384004367 dimer interface [polypeptide binding]; other site 373384004368 motif 1; other site 373384004369 motif 3; other site 373384004370 motif 2; other site 373384004371 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 373384004372 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 373384004373 IHF dimer interface [polypeptide binding]; other site 373384004374 IHF - DNA interface [nucleotide binding]; other site 373384004375 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 373384004376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384004377 ABC-ATPase subunit interface; other site 373384004378 dimer interface [polypeptide binding]; other site 373384004379 putative PBP binding regions; other site 373384004380 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 373384004381 catalytic residues [active] 373384004382 dimer interface [polypeptide binding]; other site 373384004383 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 373384004384 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 373384004385 Walker A/P-loop; other site 373384004386 ATP binding site [chemical binding]; other site 373384004387 Q-loop/lid; other site 373384004388 ABC transporter signature motif; other site 373384004389 Walker B; other site 373384004390 D-loop; other site 373384004391 H-loop/switch region; other site 373384004392 NlpC/P60 family; Region: NLPC_P60; pfam00877 373384004393 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384004394 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384004395 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384004396 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 373384004397 hypothetical protein; Validated; Region: PRK00029 373384004398 Uncharacterized conserved protein [Function unknown]; Region: COG0397 373384004399 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 373384004400 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 373384004401 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 373384004402 PEP synthetase regulatory protein; Provisional; Region: PRK05339 373384004403 phosphoenolpyruvate synthase; Validated; Region: PRK06464 373384004404 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 373384004405 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373384004406 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 373384004407 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 373384004408 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 373384004409 acyl-activating enzyme (AAE) consensus motif; other site 373384004410 putative AMP binding site [chemical binding]; other site 373384004411 putative active site [active] 373384004412 putative CoA binding site [chemical binding]; other site 373384004413 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 373384004414 oxidoreductase; Provisional; Region: PRK10015 373384004415 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 373384004416 Electron transfer flavoprotein domain; Region: ETF; smart00893 373384004417 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 373384004418 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 373384004419 Ligand binding site [chemical binding]; other site 373384004420 Electron transfer flavoprotein domain; Region: ETF; pfam01012 373384004421 Cupin domain; Region: Cupin_2; pfam07883 373384004422 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004423 transcriptional regulator YdeO; Provisional; Region: PRK09940 373384004424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384004425 putative oxidoreductase; Provisional; Region: PRK09939 373384004426 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 373384004427 putative molybdopterin cofactor binding site [chemical binding]; other site 373384004428 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 373384004429 putative molybdopterin cofactor binding site; other site 373384004430 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 373384004431 mannosyl binding site [chemical binding]; other site 373384004432 Fimbrial protein; Region: Fimbrial; pfam00419 373384004433 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384004435 Integrase core domain; Region: rve; pfam00665 373384004436 Integrase core domain; Region: rve_3; pfam13683 373384004437 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 373384004438 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 373384004439 Protein of unknown function (DUF968); Region: DUF968; pfam06147 373384004440 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 373384004441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384004442 Integrase core domain; Region: rve; pfam00665 373384004443 Integrase core domain; Region: rve_3; pfam13683 373384004444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004445 Transposase; Region: HTH_Tnp_1; pfam01527 373384004446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004447 putative substrate translocation pore; other site 373384004448 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 373384004449 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 373384004450 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 373384004451 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 373384004452 Transcriptional regulators [Transcription]; Region: GntR; COG1802 373384004453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384004454 DNA-binding site [nucleotide binding]; DNA binding site 373384004455 FCD domain; Region: FCD; pfam07729 373384004456 malonic semialdehyde reductase; Provisional; Region: PRK10538 373384004457 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 373384004458 putative NAD(P) binding site [chemical binding]; other site 373384004459 homodimer interface [polypeptide binding]; other site 373384004460 homotetramer interface [polypeptide binding]; other site 373384004461 active site 373384004462 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 373384004463 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 373384004464 active site 373384004465 Zn binding site [ion binding]; other site 373384004466 hypothetical protein; Validated; Region: PRK03657 373384004467 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 373384004468 HTH-like domain; Region: HTH_21; pfam13276 373384004469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384004470 Integrase core domain; Region: rve; pfam00665 373384004471 Integrase core domain; Region: rve_3; pfam13683 373384004472 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384004473 molybdopterin cofactor binding site; other site 373384004474 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 373384004475 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 373384004476 hypothetical protein; Provisional; Region: PRK13659 373384004477 hypothetical protein; Provisional; Region: PRK02237 373384004478 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 373384004479 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 373384004480 putative active site pocket [active] 373384004481 putative metal binding site [ion binding]; other site 373384004482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004483 Transposase; Region: HTH_Tnp_1; pfam01527 373384004484 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384004485 HTH-like domain; Region: HTH_21; pfam13276 373384004486 Integrase core domain; Region: rve; pfam00665 373384004487 Integrase core domain; Region: rve_3; pfam13683 373384004488 Transposase; Region: HTH_Tnp_1; cl17663 373384004489 transcriptional regulator LsrR; Provisional; Region: PRK15418 373384004490 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 373384004491 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 373384004492 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 373384004493 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373384004494 Walker A/P-loop; other site 373384004495 ATP binding site [chemical binding]; other site 373384004496 Q-loop/lid; other site 373384004497 ABC transporter signature motif; other site 373384004498 Walker B; other site 373384004499 D-loop; other site 373384004500 H-loop/switch region; other site 373384004501 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 373384004502 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384004503 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384004504 TM-ABC transporter signature motif; other site 373384004505 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384004506 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384004507 TM-ABC transporter signature motif; other site 373384004508 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384004509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004510 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384004511 HTH-like domain; Region: HTH_21; pfam13276 373384004512 Integrase core domain; Region: rve; pfam00665 373384004513 Integrase core domain; Region: rve_3; pfam13683 373384004514 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 373384004515 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 373384004516 putative active site; other site 373384004517 catalytic residue [active] 373384004518 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 373384004519 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 373384004520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384004521 S-adenosylmethionine binding site [chemical binding]; other site 373384004522 Predicted membrane protein [Function unknown]; Region: COG3781 373384004523 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 373384004524 Putative transposase; Region: Y2_Tnp; pfam04986 373384004525 altronate oxidoreductase; Provisional; Region: PRK03643 373384004526 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 373384004527 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 373384004528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373384004529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384004530 metal binding site [ion binding]; metal-binding site 373384004531 active site 373384004532 I-site; other site 373384004533 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 373384004534 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 373384004535 glutaminase; Provisional; Region: PRK00971 373384004536 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004537 putative arabinose transporter; Provisional; Region: PRK03545 373384004538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004539 putative substrate translocation pore; other site 373384004540 inner membrane protein; Provisional; Region: PRK10995 373384004541 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 373384004542 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 373384004543 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 373384004544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384004545 hypothetical protein; Provisional; Region: PRK10106 373384004546 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 373384004547 EamA-like transporter family; Region: EamA; pfam00892 373384004548 EamA-like transporter family; Region: EamA; pfam00892 373384004549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004550 putative substrate translocation pore; other site 373384004551 putative transporter; Provisional; Region: PRK10054 373384004552 HTH-like domain; Region: HTH_21; pfam13276 373384004553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384004554 Integrase core domain; Region: rve; pfam00665 373384004555 Integrase core domain; Region: rve_3; pfam13683 373384004556 Homeodomain-like domain; Region: HTH_23; pfam13384 373384004557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004558 Transposase; Region: HTH_Tnp_1; pfam01527 373384004559 Transposase; Region: HTH_Tnp_1; cl17663 373384004560 Integrase core domain; Region: rve; pfam00665 373384004561 Integrase core domain; Region: rve_3; pfam13683 373384004562 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384004563 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 373384004564 putative molybdopterin cofactor binding site; other site 373384004565 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 373384004566 4Fe-4S binding domain; Region: Fer4; cl02805 373384004567 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 373384004568 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 373384004569 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 373384004570 Cl- selectivity filter; other site 373384004571 Cl- binding residues [ion binding]; other site 373384004572 pore gating glutamate residue; other site 373384004573 dimer interface [polypeptide binding]; other site 373384004574 putative dithiobiotin synthetase; Provisional; Region: PRK12374 373384004575 AAA domain; Region: AAA_26; pfam13500 373384004576 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 373384004577 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373384004578 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373384004579 nucleotide binding site [chemical binding]; other site 373384004580 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 373384004581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384004582 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 373384004583 dimerization interface [polypeptide binding]; other site 373384004584 substrate binding pocket [chemical binding]; other site 373384004585 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 373384004586 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 373384004587 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 373384004588 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 373384004589 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373384004590 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 373384004591 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 373384004592 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 373384004593 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 373384004594 ligand binding site [chemical binding]; other site 373384004595 homodimer interface [polypeptide binding]; other site 373384004596 NAD(P) binding site [chemical binding]; other site 373384004597 trimer interface B [polypeptide binding]; other site 373384004598 trimer interface A [polypeptide binding]; other site 373384004599 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 373384004600 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 373384004601 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 373384004602 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 373384004603 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 373384004604 Spore germination protein; Region: Spore_permease; cl17796 373384004605 dihydromonapterin reductase; Provisional; Region: PRK06483 373384004606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373384004607 NAD(P) binding site [chemical binding]; other site 373384004608 active site 373384004609 GlpM protein; Region: GlpM; pfam06942 373384004610 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 373384004611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384004612 active site 373384004613 phosphorylation site [posttranslational modification] 373384004614 intermolecular recognition site; other site 373384004615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384004616 DNA binding site [nucleotide binding] 373384004617 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 373384004618 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 373384004619 sensor protein RstB; Provisional; Region: PRK10604 373384004620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384004621 dimerization interface [polypeptide binding]; other site 373384004622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384004623 dimer interface [polypeptide binding]; other site 373384004624 phosphorylation site [posttranslational modification] 373384004625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384004626 ATP binding site [chemical binding]; other site 373384004627 Mg2+ binding site [ion binding]; other site 373384004628 G-X-G motif; other site 373384004629 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 373384004630 fumarate hydratase; Reviewed; Region: fumC; PRK00485 373384004631 Class II fumarases; Region: Fumarase_classII; cd01362 373384004632 active site 373384004633 tetramer interface [polypeptide binding]; other site 373384004634 fumarate hydratase; Provisional; Region: PRK15389 373384004635 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 373384004636 Fumarase C-terminus; Region: Fumerase_C; pfam05683 373384004637 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 373384004638 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 373384004639 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 373384004640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 373384004641 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 373384004642 putative outer membrane porin protein; Provisional; Region: PRK11379 373384004643 beta-D-glucuronidase; Provisional; Region: PRK10150 373384004644 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 373384004645 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 373384004646 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 373384004647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373384004648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384004649 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004650 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 373384004651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384004652 DNA binding site [nucleotide binding] 373384004653 domain linker motif; other site 373384004654 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 373384004655 putative dimerization interface [polypeptide binding]; other site 373384004656 putative ligand binding site [chemical binding]; other site 373384004657 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 373384004658 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 373384004659 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 373384004660 active site turn [active] 373384004661 phosphorylation site [posttranslational modification] 373384004662 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 373384004663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384004664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384004665 homodimer interface [polypeptide binding]; other site 373384004666 catalytic residue [active] 373384004667 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 373384004668 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 373384004669 active site 373384004670 purine riboside binding site [chemical binding]; other site 373384004671 putative oxidoreductase; Provisional; Region: PRK11579 373384004672 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373384004673 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 373384004674 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 373384004675 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 373384004676 electron transport complex protein RsxA; Provisional; Region: PRK05151 373384004677 electron transport complex protein RnfB; Provisional; Region: PRK05113 373384004678 Putative Fe-S cluster; Region: FeS; pfam04060 373384004679 4Fe-4S binding domain; Region: Fer4; pfam00037 373384004680 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 373384004681 SLBB domain; Region: SLBB; pfam10531 373384004682 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384004683 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 373384004684 electron transport complex protein RnfG; Validated; Region: PRK01908 373384004685 electron transport complex RsxE subunit; Provisional; Region: PRK12405 373384004686 endonuclease III; Provisional; Region: PRK10702 373384004687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373384004688 minor groove reading motif; other site 373384004689 helix-hairpin-helix signature motif; other site 373384004690 substrate binding pocket [chemical binding]; other site 373384004691 active site 373384004692 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 373384004693 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 373384004694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004695 putative substrate translocation pore; other site 373384004696 POT family; Region: PTR2; pfam00854 373384004697 glutathionine S-transferase; Provisional; Region: PRK10542 373384004698 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 373384004699 C-terminal domain interface [polypeptide binding]; other site 373384004700 GSH binding site (G-site) [chemical binding]; other site 373384004701 dimer interface [polypeptide binding]; other site 373384004702 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 373384004703 N-terminal domain interface [polypeptide binding]; other site 373384004704 dimer interface [polypeptide binding]; other site 373384004705 substrate binding pocket (H-site) [chemical binding]; other site 373384004706 pyridoxamine kinase; Validated; Region: PRK05756 373384004707 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 373384004708 dimer interface [polypeptide binding]; other site 373384004709 pyridoxal binding site [chemical binding]; other site 373384004710 ATP binding site [chemical binding]; other site 373384004711 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 373384004712 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 373384004713 active site 373384004714 HIGH motif; other site 373384004715 dimer interface [polypeptide binding]; other site 373384004716 KMSKS motif; other site 373384004717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384004718 RNA binding surface [nucleotide binding]; other site 373384004719 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 373384004720 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 373384004721 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 373384004722 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 373384004723 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384004724 HTH-like domain; Region: HTH_21; pfam13276 373384004725 Integrase core domain; Region: rve; pfam00665 373384004726 Integrase core domain; Region: rve_3; pfam13683 373384004727 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384004728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004729 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 373384004730 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 373384004731 transcriptional regulator SlyA; Provisional; Region: PRK03573 373384004732 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 373384004733 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 373384004734 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 373384004735 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384004736 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384004737 Fusaric acid resistance protein family; Region: FUSC; pfam04632 373384004738 Fusaric acid resistance protein family; Region: FUSC; pfam04632 373384004739 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 373384004740 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 373384004741 E-class dimer interface [polypeptide binding]; other site 373384004742 P-class dimer interface [polypeptide binding]; other site 373384004743 active site 373384004744 Cu2+ binding site [ion binding]; other site 373384004745 Zn2+ binding site [ion binding]; other site 373384004746 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384004747 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384004748 active site 373384004749 catalytic tetrad [active] 373384004750 Predicted Fe-S protein [General function prediction only]; Region: COG3313 373384004751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373384004752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384004753 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 373384004754 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 373384004755 FMN binding site [chemical binding]; other site 373384004756 active site 373384004757 substrate binding site [chemical binding]; other site 373384004758 catalytic residue [active] 373384004759 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373384004760 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 373384004761 dimer interface [polypeptide binding]; other site 373384004762 active site 373384004763 metal binding site [ion binding]; metal-binding site 373384004764 glutathione binding site [chemical binding]; other site 373384004765 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 373384004766 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 373384004767 dimer interface [polypeptide binding]; other site 373384004768 catalytic site [active] 373384004769 putative active site [active] 373384004770 putative substrate binding site [chemical binding]; other site 373384004771 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 373384004772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384004773 ATP binding site [chemical binding]; other site 373384004774 putative Mg++ binding site [ion binding]; other site 373384004775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384004776 nucleotide binding region [chemical binding]; other site 373384004777 ATP-binding site [chemical binding]; other site 373384004778 DEAD/H associated; Region: DEAD_assoc; pfam08494 373384004779 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 373384004780 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 373384004781 Probable transposase; Region: OrfB_IS605; pfam01385 373384004782 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 373384004783 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373384004784 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 373384004785 putative GSH binding site [chemical binding]; other site 373384004786 catalytic residues [active] 373384004787 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 373384004788 NlpC/P60 family; Region: NLPC_P60; pfam00877 373384004789 superoxide dismutase; Provisional; Region: PRK10543 373384004790 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 373384004791 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 373384004792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384004794 putative substrate translocation pore; other site 373384004795 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 373384004796 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384004797 DNA binding site [nucleotide binding] 373384004798 domain linker motif; other site 373384004799 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 373384004800 dimerization interface [polypeptide binding]; other site 373384004801 ligand binding site [chemical binding]; other site 373384004802 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 373384004803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384004804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384004805 dimerization interface [polypeptide binding]; other site 373384004806 putative transporter; Provisional; Region: PRK11043 373384004807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004808 putative substrate translocation pore; other site 373384004809 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 373384004810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 373384004811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384004812 S-adenosylmethionine binding site [chemical binding]; other site 373384004813 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 373384004814 Lumazine binding domain; Region: Lum_binding; pfam00677 373384004815 Lumazine binding domain; Region: Lum_binding; pfam00677 373384004816 multidrug efflux protein; Reviewed; Region: PRK01766 373384004817 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 373384004818 cation binding site [ion binding]; other site 373384004819 hypothetical protein; Provisional; Region: PRK09945 373384004820 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 373384004821 putative monooxygenase; Provisional; Region: PRK11118 373384004822 hypothetical protein; Provisional; Region: PRK09897 373384004823 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 373384004824 hypothetical protein; Provisional; Region: PRK09946 373384004825 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 373384004826 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 373384004827 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 373384004828 hypothetical protein; Provisional; Region: PRK09947 373384004829 putative oxidoreductase; Provisional; Region: PRK09849 373384004830 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 373384004831 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 373384004832 hypothetical protein; Provisional; Region: PRK09898 373384004833 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384004834 hypothetical protein; Provisional; Region: PRK10292 373384004835 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004836 pyruvate kinase; Provisional; Region: PRK09206 373384004837 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 373384004838 active site 373384004839 domain interfaces; other site 373384004840 murein lipoprotein; Provisional; Region: PRK15396 373384004841 L,D-transpeptidase; Provisional; Region: PRK10190 373384004842 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384004843 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373384004844 cysteine desufuration protein SufE; Provisional; Region: PRK09296 373384004845 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 373384004846 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 373384004847 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373384004848 catalytic residue [active] 373384004849 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 373384004850 FeS assembly protein SufD; Region: sufD; TIGR01981 373384004851 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 373384004852 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 373384004853 Walker A/P-loop; other site 373384004854 ATP binding site [chemical binding]; other site 373384004855 Q-loop/lid; other site 373384004856 ABC transporter signature motif; other site 373384004857 Walker B; other site 373384004858 D-loop; other site 373384004859 H-loop/switch region; other site 373384004860 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 373384004861 putative ABC transporter; Region: ycf24; CHL00085 373384004862 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 373384004863 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 373384004864 CoenzymeA binding site [chemical binding]; other site 373384004865 subunit interaction site [polypeptide binding]; other site 373384004866 PHB binding site; other site 373384004867 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 373384004868 FAD binding domain; Region: FAD_binding_4; pfam01565 373384004869 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 373384004870 putative inner membrane protein; Provisional; Region: PRK10983 373384004871 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373384004872 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 373384004873 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384004875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384004876 putative substrate translocation pore; other site 373384004877 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004878 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 373384004879 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 373384004880 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 373384004881 shikimate binding site; other site 373384004882 NAD(P) binding site [chemical binding]; other site 373384004883 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 373384004884 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 373384004885 active site 373384004886 catalytic residue [active] 373384004887 dimer interface [polypeptide binding]; other site 373384004888 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004889 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 373384004890 Sulfatase; Region: Sulfatase; pfam00884 373384004891 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 373384004892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384004893 FeS/SAM binding site; other site 373384004894 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 373384004895 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004896 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 373384004897 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 373384004898 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004899 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 373384004900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384004901 catalytic residue [active] 373384004902 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 373384004903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 373384004904 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 373384004905 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 373384004906 heme-binding site [chemical binding]; other site 373384004907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373384004908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384004909 metal binding site [ion binding]; metal-binding site 373384004910 active site 373384004911 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384004912 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 373384004913 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 373384004914 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 373384004915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384004916 dimer interface [polypeptide binding]; other site 373384004917 conserved gate region; other site 373384004918 putative PBP binding loops; other site 373384004919 ABC-ATPase subunit interface; other site 373384004920 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 373384004921 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384004922 Walker A/P-loop; other site 373384004923 ATP binding site [chemical binding]; other site 373384004924 Q-loop/lid; other site 373384004925 ABC transporter signature motif; other site 373384004926 Walker B; other site 373384004927 D-loop; other site 373384004928 H-loop/switch region; other site 373384004929 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 373384004930 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 373384004931 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384004932 Walker A/P-loop; other site 373384004933 ATP binding site [chemical binding]; other site 373384004934 Q-loop/lid; other site 373384004935 ABC transporter signature motif; other site 373384004936 Walker B; other site 373384004937 D-loop; other site 373384004938 H-loop/switch region; other site 373384004939 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 373384004940 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 373384004941 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004942 malate dehydrogenase; Provisional; Region: PRK13529 373384004943 Malic enzyme, N-terminal domain; Region: malic; pfam00390 373384004944 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 373384004945 NAD(P) binding site [chemical binding]; other site 373384004946 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 373384004947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384004948 non-specific DNA binding site [nucleotide binding]; other site 373384004949 salt bridge; other site 373384004950 sequence-specific DNA binding site [nucleotide binding]; other site 373384004951 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 373384004952 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 373384004953 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 373384004954 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 373384004955 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 373384004956 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 373384004957 [4Fe-4S] binding site [ion binding]; other site 373384004958 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384004959 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 373384004960 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 373384004961 molybdopterin cofactor binding site; other site 373384004962 aromatic amino acid exporter; Provisional; Region: PRK11689 373384004963 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004964 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 373384004965 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 373384004966 trimer interface [polypeptide binding]; other site 373384004967 eyelet of channel; other site 373384004968 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 373384004969 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384004970 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 373384004971 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 373384004972 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 373384004973 [4Fe-4S] binding site [ion binding]; other site 373384004974 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384004975 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384004976 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384004977 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 373384004978 molybdopterin cofactor binding site; other site 373384004979 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 373384004980 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 373384004981 Putative transposase; Region: Y2_Tnp; pfam04986 373384004982 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 373384004983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384004984 DNA-binding site [nucleotide binding]; DNA binding site 373384004985 FCD domain; Region: FCD; pfam07729 373384004986 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 373384004987 Prostaglandin dehydrogenases; Region: PGDH; cd05288 373384004988 NAD(P) binding site [chemical binding]; other site 373384004989 substrate binding site [chemical binding]; other site 373384004990 dimer interface [polypeptide binding]; other site 373384004991 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384004992 HTH-like domain; Region: HTH_21; pfam13276 373384004993 Integrase core domain; Region: rve; pfam00665 373384004994 Integrase core domain; Region: rve_3; pfam13683 373384004995 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384004996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384004997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 373384004998 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 373384004999 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 373384005000 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 373384005001 trimer interface [polypeptide binding]; other site 373384005002 active site 373384005003 substrate binding site [chemical binding]; other site 373384005004 CoA binding site [chemical binding]; other site 373384005005 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 373384005006 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 373384005007 tetrameric interface [polypeptide binding]; other site 373384005008 NAD binding site [chemical binding]; other site 373384005009 catalytic residues [active] 373384005010 substrate binding site [chemical binding]; other site 373384005011 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 373384005012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384005013 ABC-ATPase subunit interface; other site 373384005014 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 373384005015 Putative transposase; Region: Y2_Tnp; pfam04986 373384005016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 373384005017 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 373384005018 Probable transposase; Region: OrfB_IS605; pfam01385 373384005019 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 373384005020 tellurite resistance protein TehB; Provisional; Region: PRK11207 373384005021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384005022 S-adenosylmethionine binding site [chemical binding]; other site 373384005023 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 373384005024 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 373384005025 gating phenylalanine in ion channel; other site 373384005026 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373384005027 putative trimer interface [polypeptide binding]; other site 373384005028 putative CoA binding site [chemical binding]; other site 373384005029 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 373384005030 putative trimer interface [polypeptide binding]; other site 373384005031 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 373384005032 putative CoA binding site [chemical binding]; other site 373384005033 putative trimer interface [polypeptide binding]; other site 373384005034 putative CoA binding site [chemical binding]; other site 373384005035 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 373384005036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384005037 Coenzyme A binding pocket [chemical binding]; other site 373384005038 hypothetical protein; Provisional; Region: PRK11415 373384005039 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 373384005040 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 373384005041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 373384005042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 373384005043 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 373384005044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384005045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384005046 dimerization interface [polypeptide binding]; other site 373384005047 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 373384005048 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 373384005049 dimer interface [polypeptide binding]; other site 373384005050 ligand binding site [chemical binding]; other site 373384005051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384005052 dimerization interface [polypeptide binding]; other site 373384005053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373384005054 dimer interface [polypeptide binding]; other site 373384005055 putative CheW interface [polypeptide binding]; other site 373384005056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005057 Helix-turn-helix domain; Region: HTH_28; pfam13518 373384005058 Helix-turn-helix domain; Region: HTH_28; pfam13518 373384005059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384005060 Integrase core domain; Region: rve; pfam00665 373384005061 Integrase core domain; Region: rve_3; pfam13683 373384005062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005063 Transposase; Region: HTH_Tnp_1; pfam01527 373384005064 hypothetical protein; Provisional; Region: PRK10040 373384005065 cytochrome b561; Provisional; Region: PRK11513 373384005066 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 373384005067 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 373384005068 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 373384005069 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 373384005070 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 373384005071 NAD binding site [chemical binding]; other site 373384005072 catalytic residues [active] 373384005073 substrate binding site [chemical binding]; other site 373384005074 Uncharacterized conserved protein [Function unknown]; Region: COG1434 373384005075 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373384005076 putative active site [active] 373384005077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005078 Transposase; Region: HTH_Tnp_1; pfam01527 373384005079 putative transposase OrfB; Reviewed; Region: PHA02517 373384005080 Integrase core domain; Region: rve; pfam00665 373384005081 Integrase core domain; Region: rve_3; pfam13683 373384005082 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 373384005083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384005084 ATP binding site [chemical binding]; other site 373384005085 putative Mg++ binding site [ion binding]; other site 373384005086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384005087 nucleotide binding region [chemical binding]; other site 373384005088 ATP-binding site [chemical binding]; other site 373384005089 Helicase associated domain (HA2); Region: HA2; pfam04408 373384005090 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 373384005091 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 373384005092 azoreductase; Reviewed; Region: PRK00170 373384005093 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373384005094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005095 Transposase; Region: HTH_Tnp_1; pfam01527 373384005096 Integrase core domain; Region: rve; pfam00665 373384005097 Integrase core domain; Region: rve_3; pfam13683 373384005098 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 373384005099 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373384005100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384005101 S-adenosylmethionine binding site [chemical binding]; other site 373384005102 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 373384005103 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 373384005104 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 373384005105 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 373384005106 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 373384005107 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384005108 heat-inducible protein; Provisional; Region: PRK10449 373384005109 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 373384005110 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 373384005111 putative ligand binding site [chemical binding]; other site 373384005112 putative NAD binding site [chemical binding]; other site 373384005113 catalytic site [active] 373384005114 hypothetical protein; Provisional; Region: PRK10695 373384005115 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 373384005116 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384005117 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 373384005118 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 373384005119 dimer interface [polypeptide binding]; other site 373384005120 PYR/PP interface [polypeptide binding]; other site 373384005121 TPP binding site [chemical binding]; other site 373384005122 substrate binding site [chemical binding]; other site 373384005123 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 373384005124 Domain of unknown function; Region: EKR; smart00890 373384005125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384005126 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 373384005127 TPP-binding site [chemical binding]; other site 373384005128 dimer interface [polypeptide binding]; other site 373384005129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373384005130 Ligand Binding Site [chemical binding]; other site 373384005131 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 373384005132 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 373384005133 Ligand Binding Site [chemical binding]; other site 373384005134 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 373384005135 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 373384005136 ATP binding site [chemical binding]; other site 373384005137 Mg++ binding site [ion binding]; other site 373384005138 motif III; other site 373384005139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384005140 nucleotide binding region [chemical binding]; other site 373384005141 ATP-binding site [chemical binding]; other site 373384005142 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 373384005143 putative RNA binding site [nucleotide binding]; other site 373384005144 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 373384005145 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 373384005146 Cl binding site [ion binding]; other site 373384005147 oligomer interface [polypeptide binding]; other site 373384005148 PAS domain S-box; Region: sensory_box; TIGR00229 373384005149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373384005150 putative active site [active] 373384005151 heme pocket [chemical binding]; other site 373384005152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373384005153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384005154 metal binding site [ion binding]; metal-binding site 373384005155 active site 373384005156 I-site; other site 373384005157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 373384005158 Smr domain; Region: Smr; pfam01713 373384005159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384005160 putative substrate translocation pore; other site 373384005161 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 373384005162 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384005163 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 373384005164 Putative transposase; Region: Y2_Tnp; pfam04986 373384005165 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 373384005166 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384005167 Helix-turn-helix domain; Region: HTH_18; pfam12833 373384005168 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 373384005169 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 373384005170 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 373384005171 DNA binding site [nucleotide binding] 373384005172 active site 373384005173 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 373384005174 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373384005175 ligand binding site [chemical binding]; other site 373384005176 flexible hinge region; other site 373384005177 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373384005178 putative switch regulator; other site 373384005179 non-specific DNA interactions [nucleotide binding]; other site 373384005180 DNA binding site [nucleotide binding] 373384005181 sequence specific DNA binding site [nucleotide binding]; other site 373384005182 putative cAMP binding site [chemical binding]; other site 373384005183 universal stress protein UspE; Provisional; Region: PRK11175 373384005184 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373384005185 Ligand Binding Site [chemical binding]; other site 373384005186 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373384005187 Ligand Binding Site [chemical binding]; other site 373384005188 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 373384005189 Integrase core domain; Region: rve; pfam00665 373384005190 Integrase core domain; Region: rve_3; pfam13683 373384005191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005192 Transposase; Region: HTH_Tnp_1; pfam01527 373384005193 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 373384005194 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373384005195 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 373384005196 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 373384005197 peptide binding site [polypeptide binding]; other site 373384005198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005199 Transposase; Region: HTH_Tnp_1; pfam01527 373384005200 HTH-like domain; Region: HTH_21; pfam13276 373384005201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384005202 Integrase core domain; Region: rve; pfam00665 373384005203 Integrase core domain; Region: rve_3; pfam13683 373384005204 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 373384005205 AAA domain; Region: AAA_24; pfam13479 373384005206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005207 Transposase; Region: HTH_Tnp_1; pfam01527 373384005208 HTH-like domain; Region: HTH_21; pfam13276 373384005209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384005210 Integrase core domain; Region: rve; pfam00665 373384005211 Integrase core domain; Region: rve_3; pfam13683 373384005212 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 373384005213 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 373384005214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384005215 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 373384005216 dimer interface [polypeptide binding]; other site 373384005217 active site 373384005218 Int/Topo IB signature motif; other site 373384005219 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 373384005220 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 373384005221 hypothetical protein; Provisional; Region: PRK10301 373384005222 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 373384005223 Predicted amidohydrolase [General function prediction only]; Region: COG0388 373384005224 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 373384005225 exodeoxyribonuclease X; Provisional; Region: PRK07983 373384005226 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 373384005227 active site 373384005228 catalytic site [active] 373384005229 substrate binding site [chemical binding]; other site 373384005230 protease 2; Provisional; Region: PRK10115 373384005231 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373384005232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 373384005233 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 373384005234 putative metal binding site [ion binding]; other site 373384005235 hypothetical protein; Provisional; Region: PRK13680 373384005236 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 373384005237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 373384005238 ATP-grasp domain; Region: ATP-grasp; pfam02222 373384005239 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 373384005240 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 373384005241 active site 373384005242 intersubunit interface [polypeptide binding]; other site 373384005243 catalytic residue [active] 373384005244 phosphogluconate dehydratase; Validated; Region: PRK09054 373384005245 6-phosphogluconate dehydratase; Region: edd; TIGR01196 373384005246 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 373384005247 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 373384005248 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 373384005249 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 373384005250 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 373384005251 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 373384005252 putative active site [active] 373384005253 pyruvate kinase; Provisional; Region: PRK05826 373384005254 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 373384005255 domain interfaces; other site 373384005256 active site 373384005257 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 373384005258 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 373384005259 putative acyl-acceptor binding pocket; other site 373384005260 putative peptidase; Provisional; Region: PRK11649 373384005261 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 373384005262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384005263 Peptidase family M23; Region: Peptidase_M23; pfam01551 373384005264 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 373384005265 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 373384005266 metal binding site [ion binding]; metal-binding site 373384005267 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 373384005268 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 373384005269 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 373384005270 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 373384005271 ABC-ATPase subunit interface; other site 373384005272 dimer interface [polypeptide binding]; other site 373384005273 putative PBP binding regions; other site 373384005274 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 373384005275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384005276 Walker A motif; other site 373384005277 ATP binding site [chemical binding]; other site 373384005278 Walker B motif; other site 373384005279 arginine finger; other site 373384005280 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 373384005281 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 373384005282 RuvA N terminal domain; Region: RuvA_N; pfam01330 373384005283 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 373384005284 hypothetical protein; Provisional; Region: PRK11470 373384005285 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 373384005286 active site 373384005287 putative DNA-binding cleft [nucleotide binding]; other site 373384005288 dimer interface [polypeptide binding]; other site 373384005289 hypothetical protein; Validated; Region: PRK00110 373384005290 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 373384005291 nudix motif; other site 373384005292 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 373384005293 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 373384005294 dimer interface [polypeptide binding]; other site 373384005295 anticodon binding site; other site 373384005296 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 373384005297 homodimer interface [polypeptide binding]; other site 373384005298 motif 1; other site 373384005299 active site 373384005300 motif 2; other site 373384005301 GAD domain; Region: GAD; pfam02938 373384005302 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 373384005303 motif 3; other site 373384005304 Transposase; Region: DEDD_Tnp_IS110; pfam01548 373384005305 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 373384005306 DinI-like family; Region: DinI; pfam06183 373384005307 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 373384005308 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 373384005309 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 373384005310 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 373384005311 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384005312 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 373384005313 Phage-related protein, tail component [Function unknown]; Region: COG4733 373384005314 Putative phage tail protein; Region: Phage-tail_3; pfam13550 373384005315 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 373384005316 Interdomain contacts; other site 373384005317 Cytokine receptor motif; other site 373384005318 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 373384005319 Fibronectin type III protein; Region: DUF3672; pfam12421 373384005320 Phage-related protein, tail component [Function unknown]; Region: COG4723 373384005321 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 373384005322 MPN+ (JAMM) motif; other site 373384005323 Zinc-binding site [ion binding]; other site 373384005324 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 373384005325 NlpC/P60 family; Region: NLPC_P60; cl17555 373384005326 Phage minor tail protein; Region: Phage_min_tail; cl01940 373384005327 Phage-related protein [Function unknown]; Region: gp18; COG4672 373384005328 Minor tail protein T; Region: Phage_tail_T; pfam06223 373384005329 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 373384005330 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 373384005331 Bacterial Ig-like domain 2; Region: BID_2; smart00635 373384005332 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 373384005333 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 373384005334 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 373384005335 DNA packaging protein FI; Region: Packaging_FI; pfam14000 373384005336 Transposase; Region: DEDD_Tnp_IS110; pfam01548 373384005337 Y-family of DNA polymerases; Region: PolY; cl12025 373384005338 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 373384005339 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 373384005340 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 373384005341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005342 Transposase; Region: HTH_Tnp_1; pfam01527 373384005343 HTH-like domain; Region: HTH_21; pfam13276 373384005344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384005345 Integrase core domain; Region: rve; pfam00665 373384005346 Integrase core domain; Region: rve_3; pfam13683 373384005347 HTH-like domain; Region: HTH_21; pfam13276 373384005348 Integrase core domain; Region: rve; pfam00665 373384005349 Transposase; Region: HTH_Tnp_1; cl17663 373384005350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005351 tape measure domain; Region: tape_meas_nterm; TIGR02675 373384005352 Protein of unknown function DUF72; Region: DUF72; cl00777 373384005353 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 373384005354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384005355 S-adenosylmethionine binding site [chemical binding]; other site 373384005356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384005357 S-adenosylmethionine binding site [chemical binding]; other site 373384005358 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384005359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005360 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384005361 HTH-like domain; Region: HTH_21; pfam13276 373384005362 Integrase core domain; Region: rve; pfam00665 373384005363 Integrase core domain; Region: rve_3; pfam13683 373384005364 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 373384005365 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 373384005366 copper homeostasis protein CutC; Provisional; Region: PRK11572 373384005367 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 373384005368 putative metal binding site [ion binding]; other site 373384005369 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 373384005370 arginyl-tRNA synthetase; Region: argS; TIGR00456 373384005371 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 373384005372 active site 373384005373 HIGH motif; other site 373384005374 KMSK motif region; other site 373384005375 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 373384005376 tRNA binding surface [nucleotide binding]; other site 373384005377 anticodon binding site; other site 373384005378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 373384005379 Integrase core domain; Region: rve; pfam00665 373384005380 Integrase core domain; Region: rve_3; pfam13683 373384005381 putative transposase OrfB; Reviewed; Region: PHA02517 373384005382 Transposase; Region: HTH_Tnp_1; cl17663 373384005383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005384 Flagellar protein FlhE; Region: FlhE; pfam06366 373384005385 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 373384005386 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 373384005387 Integrase core domain; Region: rve; pfam00665 373384005388 Integrase core domain; Region: rve_3; pfam13683 373384005389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005390 Transposase; Region: HTH_Tnp_1; pfam01527 373384005391 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 373384005392 metal binding triad [ion binding]; metal-binding site 373384005393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384005394 Integrase core domain; Region: rve; pfam00665 373384005395 Integrase core domain; Region: rve_3; pfam13683 373384005396 chemotaxis regulator CheZ; Provisional; Region: PRK11166 373384005397 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 373384005398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384005399 active site 373384005400 phosphorylation site [posttranslational modification] 373384005401 intermolecular recognition site; other site 373384005402 dimerization interface [polypeptide binding]; other site 373384005403 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 373384005404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384005405 active site 373384005406 phosphorylation site [posttranslational modification] 373384005407 intermolecular recognition site; other site 373384005408 dimerization interface [polypeptide binding]; other site 373384005409 CheB methylesterase; Region: CheB_methylest; pfam01339 373384005410 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 373384005411 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 373384005412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384005413 S-adenosylmethionine binding site [chemical binding]; other site 373384005414 methyl-accepting protein IV; Provisional; Region: PRK09793 373384005415 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 373384005416 dimer interface [polypeptide binding]; other site 373384005417 ligand binding site [chemical binding]; other site 373384005418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384005419 dimerization interface [polypeptide binding]; other site 373384005420 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373384005421 dimer interface [polypeptide binding]; other site 373384005422 putative CheW interface [polypeptide binding]; other site 373384005423 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 373384005424 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 373384005425 dimer interface [polypeptide binding]; other site 373384005426 ligand binding site [chemical binding]; other site 373384005427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384005428 dimerization interface [polypeptide binding]; other site 373384005429 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373384005430 dimer interface [polypeptide binding]; other site 373384005431 putative CheW interface [polypeptide binding]; other site 373384005432 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 373384005433 putative CheA interaction surface; other site 373384005434 chemotaxis protein CheA; Provisional; Region: PRK10547 373384005435 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373384005436 putative binding surface; other site 373384005437 active site 373384005438 CheY binding; Region: CheY-binding; pfam09078 373384005439 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 373384005440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384005441 ATP binding site [chemical binding]; other site 373384005442 Mg2+ binding site [ion binding]; other site 373384005443 G-X-G motif; other site 373384005444 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 373384005445 flagellar motor protein MotB; Validated; Region: motB; PRK09041 373384005446 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 373384005447 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373384005448 ligand binding site [chemical binding]; other site 373384005449 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 373384005450 flagellar motor protein MotA; Validated; Region: PRK09110 373384005451 transcriptional activator FlhC; Provisional; Region: PRK12722 373384005452 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373384005453 Ligand Binding Site [chemical binding]; other site 373384005454 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 373384005455 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 373384005456 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384005457 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384005458 TM-ABC transporter signature motif; other site 373384005459 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 373384005460 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373384005461 Walker A/P-loop; other site 373384005462 ATP binding site [chemical binding]; other site 373384005463 Q-loop/lid; other site 373384005464 ABC transporter signature motif; other site 373384005465 Walker B; other site 373384005466 D-loop; other site 373384005467 H-loop/switch region; other site 373384005468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384005469 Walker A/P-loop; other site 373384005470 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 373384005471 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 373384005472 ligand binding site [chemical binding]; other site 373384005473 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 373384005474 Ferritin-like domain; Region: Ferritin; pfam00210 373384005475 ferroxidase diiron center [ion binding]; other site 373384005476 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 373384005477 YecR-like lipoprotein; Region: YecR; pfam13992 373384005478 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 373384005479 Ferritin-like domain; Region: Ferritin; pfam00210 373384005480 ferroxidase diiron center [ion binding]; other site 373384005481 probable metal-binding protein; Region: matur_matur; TIGR03853 373384005482 tyrosine transporter TyrP; Provisional; Region: PRK15132 373384005483 aromatic amino acid transport protein; Region: araaP; TIGR00837 373384005484 hypothetical protein; Provisional; Region: PRK10396 373384005485 yecA family protein; Region: ygfB_yecA; TIGR02292 373384005486 SEC-C motif; Region: SEC-C; pfam02810 373384005487 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 373384005488 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 373384005489 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 373384005490 active site 373384005491 catalytic site [active] 373384005492 putative DNA binding site [nucleotide binding]; other site 373384005493 GIY-YIG motif/motif A; other site 373384005494 metal binding site [ion binding]; metal-binding site 373384005495 UvrB/uvrC motif; Region: UVR; pfam02151 373384005496 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 373384005497 Helix-hairpin-helix motif; Region: HHH; pfam00633 373384005498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384005499 response regulator; Provisional; Region: PRK09483 373384005500 active site 373384005501 phosphorylation site [posttranslational modification] 373384005502 intermolecular recognition site; other site 373384005503 dimerization interface [polypeptide binding]; other site 373384005504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384005505 DNA binding residues [nucleotide binding] 373384005506 dimerization interface [polypeptide binding]; other site 373384005507 hypothetical protein; Provisional; Region: PRK10613 373384005508 Autoinducer binding domain; Region: Autoind_bind; pfam03472 373384005509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384005510 DNA binding residues [nucleotide binding] 373384005511 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 373384005512 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 373384005513 Walker A/P-loop; other site 373384005514 ATP binding site [chemical binding]; other site 373384005515 Q-loop/lid; other site 373384005516 ABC transporter signature motif; other site 373384005517 Walker B; other site 373384005518 D-loop; other site 373384005519 H-loop/switch region; other site 373384005520 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373384005521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384005522 dimer interface [polypeptide binding]; other site 373384005523 conserved gate region; other site 373384005524 putative PBP binding loops; other site 373384005525 ABC-ATPase subunit interface; other site 373384005526 D-cysteine desulfhydrase; Validated; Region: PRK03910 373384005527 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 373384005528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384005529 catalytic residue [active] 373384005530 cystine transporter subunit; Provisional; Region: PRK11260 373384005531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384005532 substrate binding pocket [chemical binding]; other site 373384005533 membrane-bound complex binding site; other site 373384005534 hinge residues; other site 373384005535 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 373384005536 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 373384005537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373384005538 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373384005539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373384005540 DNA binding residues [nucleotide binding] 373384005541 flagellin; Validated; Region: PRK08026 373384005542 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 373384005543 Flagellin protein; Region: FliC; pfam12445 373384005544 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 373384005545 flagellar capping protein; Reviewed; Region: fliD; PRK08032 373384005546 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 373384005547 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 373384005548 Flagellar protein FliS; Region: FliS; cl00654 373384005549 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 373384005550 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 373384005551 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 373384005552 active site 373384005553 Na/Ca binding site [ion binding]; other site 373384005554 catalytic site [active] 373384005555 lipoprotein; Provisional; Region: PRK10397 373384005556 putative inner membrane protein; Provisional; Region: PRK11099 373384005557 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 373384005558 CPxP motif; other site 373384005559 Probable transposase; Region: OrfB_IS605; pfam01385 373384005560 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 373384005561 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 373384005562 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 373384005563 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 373384005564 trimer interface [polypeptide binding]; other site 373384005565 eyelet of channel; other site 373384005566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373384005567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384005568 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 373384005569 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 373384005570 flagellar motor switch protein FliG; Region: fliG; TIGR00207 373384005571 FliG C-terminal domain; Region: FliG_C; pfam01706 373384005572 flagellar assembly protein H; Validated; Region: fliH; PRK05687 373384005573 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 373384005574 Flagellar assembly protein FliH; Region: FliH; pfam02108 373384005575 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 373384005576 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 373384005577 Walker A motif/ATP binding site; other site 373384005578 Walker B motif; other site 373384005579 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 373384005580 flagellar hook-length control protein; Provisional; Region: PRK10118 373384005581 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 373384005582 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 373384005583 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 373384005584 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 373384005585 flagellar motor switch protein; Validated; Region: fliN; PRK05698 373384005586 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 373384005587 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 373384005588 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 373384005589 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 373384005590 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 373384005591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384005592 DNA binding residues [nucleotide binding] 373384005593 dimerization interface [polypeptide binding]; other site 373384005594 hypothetical protein; Provisional; Region: PRK10708 373384005595 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 373384005596 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 373384005597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384005598 metal binding site [ion binding]; metal-binding site 373384005599 active site 373384005600 I-site; other site 373384005601 hypothetical protein; Provisional; Region: PRK10062 373384005602 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 373384005603 EamA-like transporter family; Region: EamA; pfam00892 373384005604 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 373384005605 additional DNA contacts [nucleotide binding]; other site 373384005606 mismatch recognition site; other site 373384005607 active site 373384005608 zinc binding site [ion binding]; other site 373384005609 DNA intercalation site [nucleotide binding]; other site 373384005610 DNA cytosine methylase; Provisional; Region: PRK10458 373384005611 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 373384005612 cofactor binding site; other site 373384005613 DNA binding site [nucleotide binding] 373384005614 substrate interaction site [chemical binding]; other site 373384005615 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 373384005616 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373384005617 Zn2+ binding site [ion binding]; other site 373384005618 Mg2+ binding site [ion binding]; other site 373384005619 putative transposase OrfB; Reviewed; Region: PHA02517 373384005620 HTH-like domain; Region: HTH_21; pfam13276 373384005621 Integrase core domain; Region: rve; pfam00665 373384005622 Integrase core domain; Region: rve_2; pfam13333 373384005623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005624 Transposase; Region: HTH_Tnp_1; pfam01527 373384005625 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 373384005626 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 373384005627 eyelet of channel; other site 373384005628 trimer interface [polypeptide binding]; other site 373384005629 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384005630 HTH-like domain; Region: HTH_21; pfam13276 373384005631 Integrase core domain; Region: rve; pfam00665 373384005632 Integrase core domain; Region: rve_3; pfam13683 373384005633 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384005634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005635 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 373384005636 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384005637 chaperone protein HchA; Provisional; Region: PRK04155 373384005638 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 373384005639 dimer interface [polypeptide binding]; other site 373384005640 metal binding site [ion binding]; metal-binding site 373384005641 potential oxyanion hole; other site 373384005642 potential catalytic triad [active] 373384005643 conserved cys residue [active] 373384005644 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 373384005645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384005646 dimer interface [polypeptide binding]; other site 373384005647 phosphorylation site [posttranslational modification] 373384005648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384005649 ATP binding site [chemical binding]; other site 373384005650 Mg2+ binding site [ion binding]; other site 373384005651 G-X-G motif; other site 373384005652 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 373384005653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384005654 active site 373384005655 phosphorylation site [posttranslational modification] 373384005656 intermolecular recognition site; other site 373384005657 dimerization interface [polypeptide binding]; other site 373384005658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384005659 DNA binding site [nucleotide binding] 373384005660 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 373384005661 active site 373384005662 homotetramer interface [polypeptide binding]; other site 373384005663 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 373384005664 zinc/cadmium-binding protein; Provisional; Region: PRK10306 373384005665 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 373384005666 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373384005667 Methyltransferase domain; Region: Methyltransf_12; pfam08242 373384005668 S-adenosylmethionine binding site [chemical binding]; other site 373384005669 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 373384005670 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 373384005671 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384005672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384005673 Integrase core domain; Region: rve; pfam00665 373384005674 Integrase core domain; Region: rve_3; pfam13683 373384005675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005676 Transposase; Region: HTH_Tnp_1; pfam01527 373384005677 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 373384005678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384005679 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 373384005680 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 373384005681 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384005682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384005683 Homeodomain-like domain; Region: HTH_23; pfam13384 373384005684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005685 Transposase; Region: HTH_Tnp_1; pfam01527 373384005686 Lysis protein S; Region: Lysis_S; pfam04971 373384005687 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 373384005688 Protein of unknown function (DUF968); Region: DUF968; pfam06147 373384005689 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384005690 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 373384005691 active site 373384005692 substrate binding site [chemical binding]; other site 373384005693 catalytic site [active] 373384005694 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384005695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384005696 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384005697 active site 373384005698 DNA binding site [nucleotide binding] 373384005699 Int/Topo IB signature motif; other site 373384005700 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 373384005701 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384005702 active site 373384005703 DNA binding site [nucleotide binding] 373384005704 Int/Topo IB signature motif; other site 373384005705 Integrase core domain; Region: rve; pfam00665 373384005706 Integrase core domain; Region: rve_3; pfam13683 373384005707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005708 Transposase; Region: HTH_Tnp_1; pfam01527 373384005709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384005710 Transposase; Region: HTH_Tnp_1; pfam01527 373384005711 HTH-like domain; Region: HTH_21; pfam13276 373384005712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384005713 Integrase core domain; Region: rve; pfam00665 373384005714 Integrase core domain; Region: rve_3; pfam13683 373384005715 AMP nucleosidase; Provisional; Region: PRK08292 373384005716 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 373384005717 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 373384005718 hypothetical protein; Provisional; Region: PRK12378 373384005719 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 373384005720 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 373384005721 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 373384005722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384005723 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 373384005724 putative substrate binding site [chemical binding]; other site 373384005725 dimerization interface [polypeptide binding]; other site 373384005726 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 373384005727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384005728 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 373384005729 putative dimerization interface [polypeptide binding]; other site 373384005730 L,D-transpeptidase; Provisional; Region: PRK10190 373384005731 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 373384005732 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 373384005733 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 373384005734 putative dimer interface [polypeptide binding]; other site 373384005735 active site pocket [active] 373384005736 putative cataytic base [active] 373384005737 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 373384005738 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 373384005739 homotrimer interface [polypeptide binding]; other site 373384005740 Walker A motif; other site 373384005741 GTP binding site [chemical binding]; other site 373384005742 Walker B motif; other site 373384005743 HTH-like domain; Region: HTH_21; pfam13276 373384005744 Integrase core domain; Region: rve; pfam00665 373384005745 Integrase core domain; Region: rve_3; cl15866 373384005746 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384005747 exonuclease I; Provisional; Region: sbcB; PRK11779 373384005748 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 373384005749 active site 373384005750 catalytic site [active] 373384005751 substrate binding site [chemical binding]; other site 373384005752 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 373384005753 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 373384005754 CPxP motif; other site 373384005755 Sulphur transport; Region: Sulf_transp; pfam04143 373384005756 Sulphur transport; Region: Sulf_transp; pfam04143 373384005757 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 373384005758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384005759 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 373384005760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384005761 dimerization interface [polypeptide binding]; other site 373384005762 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 373384005763 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 373384005764 putative NAD(P) binding site [chemical binding]; other site 373384005765 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 373384005766 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384005767 antitoxin YefM; Provisional; Region: PRK11409 373384005768 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 373384005769 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 373384005770 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 373384005771 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 373384005772 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 373384005773 NAD binding site [chemical binding]; other site 373384005774 dimerization interface [polypeptide binding]; other site 373384005775 product binding site; other site 373384005776 substrate binding site [chemical binding]; other site 373384005777 zinc binding site [ion binding]; other site 373384005778 catalytic residues [active] 373384005779 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 373384005780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384005782 homodimer interface [polypeptide binding]; other site 373384005783 catalytic residue [active] 373384005784 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 373384005785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384005786 active site 373384005787 motif I; other site 373384005788 motif II; other site 373384005789 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 373384005790 putative active site pocket [active] 373384005791 4-fold oligomerization interface [polypeptide binding]; other site 373384005792 metal binding residues [ion binding]; metal-binding site 373384005793 3-fold/trimer interface [polypeptide binding]; other site 373384005794 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 373384005795 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 373384005796 putative active site [active] 373384005797 oxyanion strand; other site 373384005798 catalytic triad [active] 373384005799 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 373384005800 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 373384005801 catalytic residues [active] 373384005802 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 373384005803 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 373384005804 substrate binding site [chemical binding]; other site 373384005805 glutamase interaction surface [polypeptide binding]; other site 373384005806 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 373384005807 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 373384005808 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 373384005809 metal binding site [ion binding]; metal-binding site 373384005810 chain length determinant protein WzzB; Provisional; Region: PRK15471 373384005811 Chain length determinant protein; Region: Wzz; pfam02706 373384005812 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 373384005813 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 373384005814 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 373384005815 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 373384005816 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 373384005817 Probable Catalytic site; other site 373384005818 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 373384005819 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 373384005820 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373384005821 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 373384005822 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 373384005823 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 373384005824 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 373384005825 substrate binding site; other site 373384005826 tetramer interface; other site 373384005827 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 373384005828 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 373384005829 NADP binding site [chemical binding]; other site 373384005830 active site 373384005831 putative substrate binding site [chemical binding]; other site 373384005832 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 373384005833 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 373384005834 NAD binding site [chemical binding]; other site 373384005835 substrate binding site [chemical binding]; other site 373384005836 homodimer interface [polypeptide binding]; other site 373384005837 active site 373384005838 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 373384005839 active site 373384005840 tetramer interface; other site 373384005841 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 373384005842 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 373384005843 putative ADP-binding pocket [chemical binding]; other site 373384005844 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 373384005845 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 373384005846 colanic acid exporter; Provisional; Region: PRK10459 373384005847 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 373384005848 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 373384005849 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 373384005850 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 373384005851 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 373384005852 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 373384005853 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 373384005854 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 373384005855 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 373384005856 active site 373384005857 GDP-Mannose binding site [chemical binding]; other site 373384005858 dimer interface [polypeptide binding]; other site 373384005859 modified nudix motif 373384005860 metal binding site [ion binding]; metal-binding site 373384005861 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 373384005862 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 373384005863 NADP binding site [chemical binding]; other site 373384005864 active site 373384005865 putative substrate binding site [chemical binding]; other site 373384005866 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 373384005867 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 373384005868 NADP-binding site; other site 373384005869 homotetramer interface [polypeptide binding]; other site 373384005870 substrate binding site [chemical binding]; other site 373384005871 homodimer interface [polypeptide binding]; other site 373384005872 active site 373384005873 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 373384005874 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 373384005875 putative trimer interface [polypeptide binding]; other site 373384005876 putative active site [active] 373384005877 putative substrate binding site [chemical binding]; other site 373384005878 putative CoA binding site [chemical binding]; other site 373384005879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 373384005880 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384005881 putative glycosyl transferase; Provisional; Region: PRK10063 373384005882 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 373384005883 metal-binding site 373384005884 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 373384005885 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 373384005886 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373384005887 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373384005888 putative acyl transferase; Provisional; Region: PRK10191 373384005889 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373384005890 trimer interface [polypeptide binding]; other site 373384005891 active site 373384005892 substrate binding site [chemical binding]; other site 373384005893 CoA binding site [chemical binding]; other site 373384005894 putative glycosyl transferase; Provisional; Region: PRK10018 373384005895 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 373384005896 active site 373384005897 tyrosine kinase; Provisional; Region: PRK11519 373384005898 Chain length determinant protein; Region: Wzz; pfam02706 373384005899 Chain length determinant protein; Region: Wzz; cl15801 373384005900 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 373384005901 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373384005902 Low molecular weight phosphatase family; Region: LMWPc; cd00115 373384005903 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 373384005904 active site 373384005905 polysaccharide export protein Wza; Provisional; Region: PRK15078 373384005906 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 373384005907 SLBB domain; Region: SLBB; pfam10531 373384005908 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 373384005909 FOG: CBS domain [General function prediction only]; Region: COG0517 373384005910 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373384005911 Transporter associated domain; Region: CorC_HlyC; smart01091 373384005912 putative assembly protein; Provisional; Region: PRK10833 373384005913 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 373384005914 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 373384005915 trimer interface [polypeptide binding]; other site 373384005916 active site 373384005917 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 373384005918 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 373384005919 ATP-binding site [chemical binding]; other site 373384005920 Sugar specificity; other site 373384005921 Pyrimidine base specificity; other site 373384005922 Transposase; Region: DEDD_Tnp_IS110; pfam01548 373384005923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 373384005924 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 373384005925 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 373384005926 metal ion-dependent adhesion site (MIDAS); other site 373384005927 Protein phosphatase 2C; Region: PP2C_2; pfam13672 373384005928 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 373384005929 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 373384005930 substrate binding site [chemical binding]; other site 373384005931 activation loop (A-loop); other site 373384005932 putative chaperone; Provisional; Region: PRK11678 373384005933 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 373384005934 nucleotide binding site [chemical binding]; other site 373384005935 putative NEF/HSP70 interaction site [polypeptide binding]; other site 373384005936 SBD interface [polypeptide binding]; other site 373384005937 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 373384005938 AlkA N-terminal domain; Region: AlkA_N; smart01009 373384005939 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373384005940 minor groove reading motif; other site 373384005941 helix-hairpin-helix signature motif; other site 373384005942 substrate binding pocket [chemical binding]; other site 373384005943 active site 373384005944 Transposase; Region: DEDD_Tnp_IS110; pfam01548 373384005945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 373384005946 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 373384005947 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 373384005948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384005949 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384005950 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 373384005951 Protein export membrane protein; Region: SecD_SecF; cl14618 373384005952 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 373384005953 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 373384005954 putative transporter; Provisional; Region: PRK10504 373384005955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384005956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384005957 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 373384005958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384005959 dimerization interface [polypeptide binding]; other site 373384005960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384005961 dimer interface [polypeptide binding]; other site 373384005962 phosphorylation site [posttranslational modification] 373384005963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384005964 ATP binding site [chemical binding]; other site 373384005965 Mg2+ binding site [ion binding]; other site 373384005966 G-X-G motif; other site 373384005967 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 373384005968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384005969 active site 373384005970 phosphorylation site [posttranslational modification] 373384005971 intermolecular recognition site; other site 373384005972 dimerization interface [polypeptide binding]; other site 373384005973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384005974 DNA binding site [nucleotide binding] 373384005975 Uncharacterized conserved protein [Function unknown]; Region: COG3422 373384005976 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 373384005977 putative protease; Provisional; Region: PRK15452 373384005978 Peptidase family U32; Region: Peptidase_U32; pfam01136 373384005979 lipid kinase; Reviewed; Region: PRK13054 373384005980 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 373384005981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 373384005982 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 373384005983 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384005984 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 373384005985 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 373384005986 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 373384005987 active site 373384005988 P-loop; other site 373384005989 phosphorylation site [posttranslational modification] 373384005990 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 373384005991 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 373384005992 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 373384005993 intersubunit interface [polypeptide binding]; other site 373384005994 active site 373384005995 zinc binding site [ion binding]; other site 373384005996 Na+ binding site [ion binding]; other site 373384005997 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 373384005998 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 373384005999 putative active site; other site 373384006000 catalytic residue [active] 373384006001 nucleoside transporter; Region: 2A0110; TIGR00889 373384006002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384006003 putative substrate translocation pore; other site 373384006004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384006005 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 373384006006 substrate binding site [chemical binding]; other site 373384006007 ATP binding site [chemical binding]; other site 373384006008 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 373384006009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384006010 DNA-binding site [nucleotide binding]; DNA binding site 373384006011 UTRA domain; Region: UTRA; pfam07702 373384006012 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 373384006013 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 373384006014 active site 373384006015 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 373384006016 dimer interface [polypeptide binding]; other site 373384006017 substrate binding site [chemical binding]; other site 373384006018 ATP binding site [chemical binding]; other site 373384006019 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 373384006020 substrate binding site [chemical binding]; other site 373384006021 multimerization interface [polypeptide binding]; other site 373384006022 ATP binding site [chemical binding]; other site 373384006023 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 373384006024 putative metal binding site [ion binding]; other site 373384006025 putative homodimer interface [polypeptide binding]; other site 373384006026 putative homotetramer interface [polypeptide binding]; other site 373384006027 putative homodimer-homodimer interface [polypeptide binding]; other site 373384006028 putative allosteric switch controlling residues; other site 373384006029 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 373384006030 Predicted integral membrane protein [Function unknown]; Region: COG5455 373384006031 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 373384006032 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 373384006033 PapC N-terminal domain; Region: PapC_N; pfam13954 373384006034 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384006035 PapC C-terminal domain; Region: PapC_C; pfam13953 373384006036 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384006037 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384006038 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384006039 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 373384006040 antiporter inner membrane protein; Provisional; Region: PRK11670 373384006041 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 373384006042 Walker A motif; other site 373384006043 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 373384006044 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 373384006045 active site 373384006046 HIGH motif; other site 373384006047 KMSKS motif; other site 373384006048 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 373384006049 tRNA binding surface [nucleotide binding]; other site 373384006050 anticodon binding site; other site 373384006051 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 373384006052 dimer interface [polypeptide binding]; other site 373384006053 putative tRNA-binding site [nucleotide binding]; other site 373384006054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384006055 Integrase core domain; Region: rve; pfam00665 373384006056 Integrase core domain; Region: rve_3; pfam13683 373384006057 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 373384006058 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384006059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 373384006060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 373384006061 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 373384006062 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 373384006063 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 373384006064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384006065 active site 373384006066 phosphorylation site [posttranslational modification] 373384006067 intermolecular recognition site; other site 373384006068 dimerization interface [polypeptide binding]; other site 373384006069 LytTr DNA-binding domain; Region: LytTR; pfam04397 373384006070 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 373384006071 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 373384006072 GAF domain; Region: GAF; pfam01590 373384006073 Histidine kinase; Region: His_kinase; pfam06580 373384006074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384006075 ATP binding site [chemical binding]; other site 373384006076 Mg2+ binding site [ion binding]; other site 373384006077 G-X-G motif; other site 373384006078 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384006079 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384006080 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384006081 DinI-like family; Region: DinI; pfam06183 373384006082 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 373384006083 Methyltransferase domain; Region: Methyltransf_31; pfam13847 373384006084 Methyltransferase domain; Region: Methyltransf_12; pfam08242 373384006085 S-adenosylmethionine binding site [chemical binding]; other site 373384006086 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 373384006087 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 373384006088 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384006089 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 373384006090 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384006091 Fimbrial protein; Region: Fimbrial; cl01416 373384006092 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384006093 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 373384006094 HTH-like domain; Region: HTH_21; pfam13276 373384006095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384006096 Integrase core domain; Region: rve; pfam00665 373384006097 Integrase core domain; Region: rve_3; pfam13683 373384006098 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 373384006099 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 373384006100 Int/Topo IB signature motif; other site 373384006101 Transposase; Region: HTH_Tnp_1; cl17663 373384006102 putative transposase OrfB; Reviewed; Region: PHA02517 373384006103 HTH-like domain; Region: HTH_21; pfam13276 373384006104 Integrase core domain; Region: rve; pfam00665 373384006105 Integrase core domain; Region: rve_3; pfam13683 373384006106 hypothetical protein; Provisional; Region: PRK13681 373384006107 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 373384006108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384006109 dimer interface [polypeptide binding]; other site 373384006110 conserved gate region; other site 373384006111 putative PBP binding loops; other site 373384006112 ABC-ATPase subunit interface; other site 373384006113 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 373384006114 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 373384006115 Walker A/P-loop; other site 373384006116 ATP binding site [chemical binding]; other site 373384006117 Q-loop/lid; other site 373384006118 ABC transporter signature motif; other site 373384006119 Walker B; other site 373384006120 D-loop; other site 373384006121 H-loop/switch region; other site 373384006122 CBS domain; Region: CBS; pfam00571 373384006123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384006124 dimer interface [polypeptide binding]; other site 373384006125 conserved gate region; other site 373384006126 ABC-ATPase subunit interface; other site 373384006127 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 373384006128 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 373384006129 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 373384006130 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 373384006131 D-lactate dehydrogenase; Provisional; Region: PRK11183 373384006132 FAD binding domain; Region: FAD_binding_4; pfam01565 373384006133 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 373384006134 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 373384006135 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 373384006136 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 373384006137 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 373384006138 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 373384006139 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 373384006140 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 373384006141 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 373384006142 FMN binding site [chemical binding]; other site 373384006143 active site 373384006144 catalytic residues [active] 373384006145 substrate binding site [chemical binding]; other site 373384006146 hypothetical protein; Provisional; Region: PRK01821 373384006147 hypothetical protein; Provisional; Region: PRK10711 373384006148 cytidine deaminase; Provisional; Region: PRK09027 373384006149 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 373384006150 active site 373384006151 catalytic motif [active] 373384006152 Zn binding site [ion binding]; other site 373384006153 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 373384006154 active site 373384006155 catalytic motif [active] 373384006156 Zn binding site [ion binding]; other site 373384006157 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373384006158 putative active site [active] 373384006159 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 373384006160 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 373384006161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373384006162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384006163 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384006164 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384006165 TM-ABC transporter signature motif; other site 373384006166 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373384006167 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 373384006168 Walker A/P-loop; other site 373384006169 ATP binding site [chemical binding]; other site 373384006170 Q-loop/lid; other site 373384006171 ABC transporter signature motif; other site 373384006172 Walker B; other site 373384006173 D-loop; other site 373384006174 H-loop/switch region; other site 373384006175 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 373384006176 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 373384006177 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 373384006178 ligand binding site [chemical binding]; other site 373384006179 calcium binding site [ion binding]; other site 373384006180 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 373384006181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384006182 DNA binding site [nucleotide binding] 373384006183 domain linker motif; other site 373384006184 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 373384006185 dimerization interface (closed form) [polypeptide binding]; other site 373384006186 ligand binding site [chemical binding]; other site 373384006187 Predicted membrane protein [Function unknown]; Region: COG2311 373384006188 hypothetical protein; Provisional; Region: PRK10835 373384006189 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 373384006190 homodecamer interface [polypeptide binding]; other site 373384006191 GTP cyclohydrolase I; Provisional; Region: PLN03044 373384006192 active site 373384006193 putative catalytic site residues [active] 373384006194 zinc binding site [ion binding]; other site 373384006195 GTP-CH-I/GFRP interaction surface; other site 373384006196 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 373384006197 S-formylglutathione hydrolase; Region: PLN02442 373384006198 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 373384006199 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373384006200 N-terminal plug; other site 373384006201 ligand-binding site [chemical binding]; other site 373384006202 lysine transporter; Provisional; Region: PRK10836 373384006203 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 373384006204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384006205 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 373384006206 putative dimerization interface [polypeptide binding]; other site 373384006207 conserved hypothetical integral membrane protein; Region: TIGR00698 373384006208 endonuclease IV; Provisional; Region: PRK01060 373384006209 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 373384006210 AP (apurinic/apyrimidinic) site pocket; other site 373384006211 DNA interaction; other site 373384006212 Metal-binding active site; metal-binding site 373384006213 putative kinase; Provisional; Region: PRK09954 373384006214 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 373384006215 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 373384006216 substrate binding site [chemical binding]; other site 373384006217 ATP binding site [chemical binding]; other site 373384006218 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 373384006219 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 373384006220 Nucleoside recognition; Region: Gate; pfam07670 373384006221 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 373384006222 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 373384006223 active site 373384006224 tetramer interface [polypeptide binding]; other site 373384006225 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 373384006226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373384006227 ligand binding site [chemical binding]; other site 373384006228 flexible hinge region; other site 373384006229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 373384006230 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 373384006231 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 373384006232 Nucleoside recognition; Region: Gate; pfam07670 373384006233 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 373384006234 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 373384006235 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 373384006236 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384006237 substrate binding site [chemical binding]; other site 373384006238 ATP binding site [chemical binding]; other site 373384006239 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 373384006240 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 373384006241 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 373384006242 active site 373384006243 P-loop; other site 373384006244 phosphorylation site [posttranslational modification] 373384006245 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 373384006246 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 373384006247 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 373384006248 putative substrate binding site [chemical binding]; other site 373384006249 putative ATP binding site [chemical binding]; other site 373384006250 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 373384006251 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 373384006252 active site 373384006253 phosphorylation site [posttranslational modification] 373384006254 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373384006255 dimerization domain swap beta strand [polypeptide binding]; other site 373384006256 regulatory protein interface [polypeptide binding]; other site 373384006257 active site 373384006258 regulatory phosphorylation site [posttranslational modification]; other site 373384006259 sugar efflux transporter B; Provisional; Region: PRK15011 373384006260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384006261 putative substrate translocation pore; other site 373384006262 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384006263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 373384006264 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 373384006265 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 373384006266 elongation factor P; Provisional; Region: PRK04542 373384006267 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 373384006268 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 373384006269 RNA binding site [nucleotide binding]; other site 373384006270 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 373384006271 RNA binding site [nucleotide binding]; other site 373384006272 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 373384006273 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 373384006274 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 373384006275 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 373384006276 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 373384006277 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 373384006278 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 373384006279 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 373384006280 active site 373384006281 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 373384006282 NlpC/P60 family; Region: NLPC_P60; pfam00877 373384006283 phage resistance protein; Provisional; Region: PRK10551 373384006284 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 373384006285 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384006286 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 373384006287 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 373384006288 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 373384006289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384006290 dimer interface [polypeptide binding]; other site 373384006291 conserved gate region; other site 373384006292 putative PBP binding loops; other site 373384006293 ABC-ATPase subunit interface; other site 373384006294 microcin C ABC transporter permease; Provisional; Region: PRK15021 373384006295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384006296 dimer interface [polypeptide binding]; other site 373384006297 conserved gate region; other site 373384006298 ABC-ATPase subunit interface; other site 373384006299 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 373384006300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384006301 Walker A/P-loop; other site 373384006302 ATP binding site [chemical binding]; other site 373384006303 Q-loop/lid; other site 373384006304 ABC transporter signature motif; other site 373384006305 Walker B; other site 373384006306 D-loop; other site 373384006307 H-loop/switch region; other site 373384006308 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373384006309 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384006310 Walker A/P-loop; other site 373384006311 ATP binding site [chemical binding]; other site 373384006312 Q-loop/lid; other site 373384006313 ABC transporter signature motif; other site 373384006314 Walker B; other site 373384006315 D-loop; other site 373384006316 H-loop/switch region; other site 373384006317 hypothetical protein; Provisional; Region: PRK11835 373384006318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384006319 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 373384006320 putative substrate translocation pore; other site 373384006321 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 373384006322 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384006323 RNA binding surface [nucleotide binding]; other site 373384006324 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 373384006325 active site 373384006326 uracil binding [chemical binding]; other site 373384006327 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 373384006328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384006329 ATP binding site [chemical binding]; other site 373384006330 putative Mg++ binding site [ion binding]; other site 373384006331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384006332 nucleotide binding region [chemical binding]; other site 373384006333 ATP-binding site [chemical binding]; other site 373384006334 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 373384006335 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 373384006336 5S rRNA interface [nucleotide binding]; other site 373384006337 CTC domain interface [polypeptide binding]; other site 373384006338 L16 interface [polypeptide binding]; other site 373384006339 Nucleoid-associated protein [General function prediction only]; Region: COG3081 373384006340 nucleoid-associated protein NdpA; Validated; Region: PRK00378 373384006341 hypothetical protein; Provisional; Region: PRK13689 373384006342 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 373384006343 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 373384006344 Sulfatase; Region: Sulfatase; pfam00884 373384006345 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 373384006346 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 373384006347 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 373384006348 Autotransporter beta-domain; Region: Autotransporter; pfam03797 373384006349 transcriptional regulator NarP; Provisional; Region: PRK10403 373384006350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384006351 active site 373384006352 phosphorylation site [posttranslational modification] 373384006353 intermolecular recognition site; other site 373384006354 dimerization interface [polypeptide binding]; other site 373384006355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384006356 DNA binding residues [nucleotide binding] 373384006357 dimerization interface [polypeptide binding]; other site 373384006358 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 373384006359 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 373384006360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373384006361 binding surface 373384006362 TPR motif; other site 373384006363 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 373384006364 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 373384006365 catalytic residues [active] 373384006366 central insert; other site 373384006367 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 373384006368 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 373384006369 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 373384006370 heme exporter protein CcmC; Region: ccmC; TIGR01191 373384006371 heme exporter protein CcmB; Region: ccmB; TIGR01190 373384006372 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 373384006373 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 373384006374 Walker A/P-loop; other site 373384006375 ATP binding site [chemical binding]; other site 373384006376 Q-loop/lid; other site 373384006377 ABC transporter signature motif; other site 373384006378 Walker B; other site 373384006379 D-loop; other site 373384006380 H-loop/switch region; other site 373384006381 cytochrome c-type protein NapC; Provisional; Region: PRK10617 373384006382 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 373384006383 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 373384006384 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 373384006385 4Fe-4S binding domain; Region: Fer4_5; pfam12801 373384006386 4Fe-4S binding domain; Region: Fer4; cl02805 373384006387 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 373384006388 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 373384006389 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 373384006390 [4Fe-4S] binding site [ion binding]; other site 373384006391 molybdopterin cofactor binding site; other site 373384006392 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 373384006393 molybdopterin cofactor binding site; other site 373384006394 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 373384006395 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 373384006396 secondary substrate binding site; other site 373384006397 primary substrate binding site; other site 373384006398 inhibition loop; other site 373384006399 dimerization interface [polypeptide binding]; other site 373384006400 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 373384006401 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 373384006402 Walker A/P-loop; other site 373384006403 ATP binding site [chemical binding]; other site 373384006404 Q-loop/lid; other site 373384006405 ABC transporter signature motif; other site 373384006406 Walker B; other site 373384006407 D-loop; other site 373384006408 H-loop/switch region; other site 373384006409 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 373384006410 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 373384006411 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 373384006412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384006413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384006414 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 373384006415 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 373384006416 DNA binding site [nucleotide binding] 373384006417 active site 373384006418 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 373384006419 ApbE family; Region: ApbE; pfam02424 373384006420 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 373384006421 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 373384006422 trimer interface [polypeptide binding]; other site 373384006423 eyelet of channel; other site 373384006424 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 373384006425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384006426 ATP binding site [chemical binding]; other site 373384006427 G-X-G motif; other site 373384006428 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373384006429 putative binding surface; other site 373384006430 active site 373384006431 transcriptional regulator RcsB; Provisional; Region: PRK10840 373384006432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384006433 active site 373384006434 phosphorylation site [posttranslational modification] 373384006435 intermolecular recognition site; other site 373384006436 dimerization interface [polypeptide binding]; other site 373384006437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384006438 DNA binding residues [nucleotide binding] 373384006439 dimerization interface [polypeptide binding]; other site 373384006440 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 373384006441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384006442 dimer interface [polypeptide binding]; other site 373384006443 phosphorylation site [posttranslational modification] 373384006444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384006445 ATP binding site [chemical binding]; other site 373384006446 Mg2+ binding site [ion binding]; other site 373384006447 G-X-G motif; other site 373384006448 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 373384006449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384006450 active site 373384006451 phosphorylation site [posttranslational modification] 373384006452 intermolecular recognition site; other site 373384006453 dimerization interface [polypeptide binding]; other site 373384006454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 373384006455 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 373384006456 Predicted secreted protein [Function unknown]; Region: COG5445 373384006457 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 373384006458 Predicted secreted protein [Function unknown]; Region: COG5445 373384006459 Stage II sporulation protein; Region: SpoIID; pfam08486 373384006460 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 373384006461 putative transposase OrfB; Reviewed; Region: PHA02517 373384006462 HTH-like domain; Region: HTH_21; pfam13276 373384006463 Integrase core domain; Region: rve; pfam00665 373384006464 Integrase core domain; Region: rve_3; pfam13683 373384006465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384006466 Transposase; Region: HTH_Tnp_1; pfam01527 373384006467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 373384006468 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 373384006469 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916 373384006470 DNA gyrase subunit A; Validated; Region: PRK05560 373384006471 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 373384006472 CAP-like domain; other site 373384006473 active site 373384006474 primary dimer interface [polypeptide binding]; other site 373384006475 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373384006476 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373384006477 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373384006478 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373384006479 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373384006480 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373384006481 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 373384006482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384006483 S-adenosylmethionine binding site [chemical binding]; other site 373384006484 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384006485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384006486 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384006487 HTH-like domain; Region: HTH_21; pfam13276 373384006488 Integrase core domain; Region: rve; pfam00665 373384006489 Integrase core domain; Region: rve_3; pfam13683 373384006490 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 373384006491 ATP cone domain; Region: ATP-cone; pfam03477 373384006492 Class I ribonucleotide reductase; Region: RNR_I; cd01679 373384006493 active site 373384006494 dimer interface [polypeptide binding]; other site 373384006495 catalytic residues [active] 373384006496 effector binding site; other site 373384006497 R2 peptide binding site; other site 373384006498 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 373384006499 dimer interface [polypeptide binding]; other site 373384006500 putative radical transfer pathway; other site 373384006501 diiron center [ion binding]; other site 373384006502 tyrosyl radical; other site 373384006503 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373384006504 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373384006505 catalytic loop [active] 373384006506 iron binding site [ion binding]; other site 373384006507 hypothetical protein; Provisional; Region: PRK09902 373384006508 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 373384006509 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 373384006510 active site 373384006511 catalytic site [active] 373384006512 metal binding site [ion binding]; metal-binding site 373384006513 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 373384006514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384006515 putative substrate translocation pore; other site 373384006516 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 373384006517 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373384006518 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 373384006519 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 373384006520 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 373384006521 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 373384006522 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384006523 Cysteine-rich domain; Region: CCG; pfam02754 373384006524 Cysteine-rich domain; Region: CCG; pfam02754 373384006525 hypothetical protein; Provisional; Region: PRK09956 373384006526 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 373384006527 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 373384006528 Competence-damaged protein; Region: CinA; cl00666 373384006529 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 373384006530 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 373384006531 putative MPT binding site; other site 373384006532 YfaZ precursor; Region: YfaZ; pfam07437 373384006533 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 373384006534 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 373384006535 catalytic core [active] 373384006536 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 373384006537 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373384006538 inhibitor-cofactor binding pocket; inhibition site 373384006539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384006540 catalytic residue [active] 373384006541 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 373384006542 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 373384006543 Ligand binding site; other site 373384006544 Putative Catalytic site; other site 373384006545 DXD motif; other site 373384006546 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 373384006547 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 373384006548 substrate binding site [chemical binding]; other site 373384006549 cosubstrate binding site; other site 373384006550 catalytic site [active] 373384006551 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 373384006552 active site 373384006553 hexamer interface [polypeptide binding]; other site 373384006554 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 373384006555 NAD binding site [chemical binding]; other site 373384006556 substrate binding site [chemical binding]; other site 373384006557 active site 373384006558 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 373384006559 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 373384006560 putative active site [active] 373384006561 putative catalytic site [active] 373384006562 putative Zn binding site [ion binding]; other site 373384006563 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 373384006564 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 373384006565 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 373384006566 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 373384006567 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 373384006568 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 373384006569 acyl-activating enzyme (AAE) consensus motif; other site 373384006570 putative AMP binding site [chemical binding]; other site 373384006571 putative active site [active] 373384006572 putative CoA binding site [chemical binding]; other site 373384006573 O-succinylbenzoate synthase; Provisional; Region: PRK05105 373384006574 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 373384006575 active site 373384006576 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 373384006577 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 373384006578 substrate binding site [chemical binding]; other site 373384006579 oxyanion hole (OAH) forming residues; other site 373384006580 trimer interface [polypeptide binding]; other site 373384006581 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 373384006582 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 373384006583 catalytic site [active] 373384006584 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 373384006585 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 373384006586 dimer interface [polypeptide binding]; other site 373384006587 tetramer interface [polypeptide binding]; other site 373384006588 PYR/PP interface [polypeptide binding]; other site 373384006589 TPP binding site [chemical binding]; other site 373384006590 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 373384006591 TPP-binding site; other site 373384006592 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 373384006593 isochorismate synthases; Region: isochor_syn; TIGR00543 373384006594 hypothetical protein; Provisional; Region: PRK10404 373384006595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384006596 Coenzyme A binding pocket [chemical binding]; other site 373384006597 ribonuclease BN; Region: true_RNase_BN; TIGR02649 373384006598 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384006599 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 373384006600 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 373384006601 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373384006602 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 373384006603 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373384006604 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 373384006605 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 373384006606 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373384006607 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 373384006608 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 373384006609 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 373384006610 4Fe-4S binding domain; Region: Fer4; pfam00037 373384006611 4Fe-4S binding domain; Region: Fer4; pfam00037 373384006612 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 373384006613 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 373384006614 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373384006615 catalytic loop [active] 373384006616 iron binding site [ion binding]; other site 373384006617 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 373384006618 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 373384006619 [4Fe-4S] binding site [ion binding]; other site 373384006620 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 373384006621 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 373384006622 SLBB domain; Region: SLBB; pfam10531 373384006623 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 373384006624 NADH dehydrogenase subunit E; Validated; Region: PRK07539 373384006625 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 373384006626 putative dimer interface [polypeptide binding]; other site 373384006627 [2Fe-2S] cluster binding site [ion binding]; other site 373384006628 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 373384006629 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 373384006630 NADH dehydrogenase subunit D; Validated; Region: PRK06075 373384006631 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 373384006632 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 373384006633 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 373384006634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384006635 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 373384006636 putative dimerization interface [polypeptide binding]; other site 373384006637 aminotransferase AlaT; Validated; Region: PRK09265 373384006638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384006639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384006640 homodimer interface [polypeptide binding]; other site 373384006641 catalytic residue [active] 373384006642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373384006643 Zn2+ binding site [ion binding]; other site 373384006644 Mg2+ binding site [ion binding]; other site 373384006645 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 373384006646 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373384006647 TrkA-C domain; Region: TrkA_C; pfam02080 373384006648 TrkA-C domain; Region: TrkA_C; pfam02080 373384006649 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 373384006650 putative phosphatase; Provisional; Region: PRK11587 373384006651 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 373384006652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384006653 motif II; other site 373384006654 hypothetical protein; Validated; Region: PRK05445 373384006655 hypothetical protein; Provisional; Region: PRK01816 373384006656 propionate/acetate kinase; Provisional; Region: PRK12379 373384006657 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 373384006658 phosphate acetyltransferase; Reviewed; Region: PRK05632 373384006659 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373384006660 DRTGG domain; Region: DRTGG; pfam07085 373384006661 phosphate acetyltransferase; Region: pta; TIGR00651 373384006662 hypothetical protein; Provisional; Region: PRK11588 373384006663 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 373384006664 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 373384006665 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 373384006666 nudix motif; other site 373384006667 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 373384006668 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373384006669 active site 373384006670 metal binding site [ion binding]; metal-binding site 373384006671 homotetramer interface [polypeptide binding]; other site 373384006672 glutathione S-transferase; Provisional; Region: PRK15113 373384006673 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 373384006674 C-terminal domain interface [polypeptide binding]; other site 373384006675 GSH binding site (G-site) [chemical binding]; other site 373384006676 dimer interface [polypeptide binding]; other site 373384006677 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 373384006678 N-terminal domain interface [polypeptide binding]; other site 373384006679 putative dimer interface [polypeptide binding]; other site 373384006680 putative substrate binding pocket (H-site) [chemical binding]; other site 373384006681 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 373384006682 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 373384006683 C-terminal domain interface [polypeptide binding]; other site 373384006684 GSH binding site (G-site) [chemical binding]; other site 373384006685 dimer interface [polypeptide binding]; other site 373384006686 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 373384006687 N-terminal domain interface [polypeptide binding]; other site 373384006688 putative dimer interface [polypeptide binding]; other site 373384006689 active site 373384006690 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 373384006691 homooctamer interface [polypeptide binding]; other site 373384006692 active site 373384006693 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 373384006694 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 373384006695 putative NAD(P) binding site [chemical binding]; other site 373384006696 putative active site [active] 373384006697 putative transposase; Provisional; Region: PRK09857 373384006698 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 373384006699 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 373384006700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 373384006701 Walker A/P-loop; other site 373384006702 ATP binding site [chemical binding]; other site 373384006703 Q-loop/lid; other site 373384006704 ABC transporter signature motif; other site 373384006705 Walker B; other site 373384006706 D-loop; other site 373384006707 H-loop/switch region; other site 373384006708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384006709 dimer interface [polypeptide binding]; other site 373384006710 conserved gate region; other site 373384006711 putative PBP binding loops; other site 373384006712 ABC-ATPase subunit interface; other site 373384006713 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373384006714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384006715 dimer interface [polypeptide binding]; other site 373384006716 conserved gate region; other site 373384006717 putative PBP binding loops; other site 373384006718 ABC-ATPase subunit interface; other site 373384006719 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 373384006720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384006721 substrate binding pocket [chemical binding]; other site 373384006722 membrane-bound complex binding site; other site 373384006723 hinge residues; other site 373384006724 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384006725 substrate binding pocket [chemical binding]; other site 373384006726 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 373384006727 membrane-bound complex binding site; other site 373384006728 hinge residues; other site 373384006729 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384006730 HTH-like domain; Region: HTH_21; pfam13276 373384006731 Integrase core domain; Region: rve; pfam00665 373384006732 Integrase core domain; Region: rve_3; pfam13683 373384006733 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384006734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384006735 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 373384006736 Flavoprotein; Region: Flavoprotein; pfam02441 373384006737 amidophosphoribosyltransferase; Provisional; Region: PRK09246 373384006738 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 373384006739 active site 373384006740 tetramer interface [polypeptide binding]; other site 373384006741 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384006742 active site 373384006743 colicin V production protein; Provisional; Region: PRK10845 373384006744 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 373384006745 cell division protein DedD; Provisional; Region: PRK11633 373384006746 Sporulation related domain; Region: SPOR; pfam05036 373384006747 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 373384006748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373384006749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373384006750 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 373384006751 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 373384006752 hypothetical protein; Provisional; Region: PRK10847 373384006753 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 373384006754 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 373384006755 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 373384006756 dimerization interface 3.5A [polypeptide binding]; other site 373384006757 active site 373384006758 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 373384006759 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 373384006760 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 373384006761 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 373384006762 ligand binding site [chemical binding]; other site 373384006763 NAD binding site [chemical binding]; other site 373384006764 catalytic site [active] 373384006765 homodimer interface [polypeptide binding]; other site 373384006766 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 373384006767 putative transporter; Provisional; Region: PRK12382 373384006768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384006769 putative substrate translocation pore; other site 373384006770 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 373384006771 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 373384006772 dimer interface [polypeptide binding]; other site 373384006773 active site 373384006774 Uncharacterized conserved protein [Function unknown]; Region: COG4121 373384006775 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 373384006776 YfcL protein; Region: YfcL; pfam08891 373384006777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 373384006778 hypothetical protein; Provisional; Region: PRK10621 373384006779 Predicted permeases [General function prediction only]; Region: COG0730 373384006780 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 373384006781 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 373384006782 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 373384006783 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 373384006784 Tetramer interface [polypeptide binding]; other site 373384006785 active site 373384006786 FMN-binding site [chemical binding]; other site 373384006787 HemK family putative methylases; Region: hemK_fam; TIGR00536 373384006788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384006789 S-adenosylmethionine binding site [chemical binding]; other site 373384006790 hypothetical protein; Provisional; Region: PRK04946 373384006791 Smr domain; Region: Smr; pfam01713 373384006792 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 373384006793 Fimbrial protein; Region: Fimbrial; cl01416 373384006794 Fimbrial protein; Region: Fimbrial; cl01416 373384006795 Fimbrial protein; Region: Fimbrial; cl01416 373384006796 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384006797 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384006798 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 373384006799 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373384006800 catalytic core [active] 373384006801 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 373384006802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 373384006803 substrate binding site [chemical binding]; other site 373384006804 oxyanion hole (OAH) forming residues; other site 373384006805 trimer interface [polypeptide binding]; other site 373384006806 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 373384006807 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 373384006808 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 373384006809 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 373384006810 dimer interface [polypeptide binding]; other site 373384006811 active site 373384006812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 373384006813 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 373384006814 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 373384006815 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 373384006816 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384006817 Integrase core domain; Region: rve; pfam00665 373384006818 Integrase core domain; Region: rve_3; pfam13683 373384006819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384006820 Transposase; Region: HTH_Tnp_1; pfam01527 373384006821 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 373384006822 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384006823 putative substrate binding site [chemical binding]; other site 373384006824 putative ATP binding site [chemical binding]; other site 373384006825 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384006826 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384006827 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384006828 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 373384006829 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 373384006830 substrate binding [chemical binding]; other site 373384006831 active site 373384006832 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 373384006833 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384006834 DNA binding site [nucleotide binding] 373384006835 domain linker motif; other site 373384006836 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 373384006837 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 373384006838 putative dimerization interface [polypeptide binding]; other site 373384006839 putative ligand binding site [chemical binding]; other site 373384006840 fructuronate transporter; Provisional; Region: PRK10034; cl15264 373384006841 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 373384006842 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 373384006843 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373384006844 catalytic residue [active] 373384006845 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 373384006846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384006847 putative substrate translocation pore; other site 373384006848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384006849 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 373384006850 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384006851 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 373384006852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384006853 active site 373384006854 phosphorylation site [posttranslational modification] 373384006855 intermolecular recognition site; other site 373384006856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384006857 DNA binding residues [nucleotide binding] 373384006858 dimerization interface [polypeptide binding]; other site 373384006859 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 373384006860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384006861 substrate binding pocket [chemical binding]; other site 373384006862 membrane-bound complex binding site; other site 373384006863 hinge residues; other site 373384006864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384006865 substrate binding pocket [chemical binding]; other site 373384006866 membrane-bound complex binding site; other site 373384006867 hinge residues; other site 373384006868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384006869 dimer interface [polypeptide binding]; other site 373384006870 phosphorylation site [posttranslational modification] 373384006871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384006872 ATP binding site [chemical binding]; other site 373384006873 Mg2+ binding site [ion binding]; other site 373384006874 G-X-G motif; other site 373384006875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384006876 active site 373384006877 phosphorylation site [posttranslational modification] 373384006878 intermolecular recognition site; other site 373384006879 dimerization interface [polypeptide binding]; other site 373384006880 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373384006881 putative binding surface; other site 373384006882 active site 373384006883 putative CoA-transferase; Provisional; Region: PRK11430 373384006884 CoA-transferase family III; Region: CoA_transf_3; pfam02515 373384006885 putative transporter YfdV; Provisional; Region: PRK09903 373384006886 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 373384006887 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373384006888 PYR/PP interface [polypeptide binding]; other site 373384006889 dimer interface [polypeptide binding]; other site 373384006890 TPP binding site [chemical binding]; other site 373384006891 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373384006892 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 373384006893 TPP-binding site; other site 373384006894 dimer interface [polypeptide binding]; other site 373384006895 formyl-coenzyme A transferase; Provisional; Region: PRK05398 373384006896 CoA-transferase family III; Region: CoA_transf_3; pfam02515 373384006897 hypothetical protein; Provisional; Region: PRK10316 373384006898 YfdX protein; Region: YfdX; pfam10938 373384006899 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 373384006900 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 373384006901 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 373384006902 putative acyl-acceptor binding pocket; other site 373384006903 aminotransferase; Validated; Region: PRK08175 373384006904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384006905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384006906 homodimer interface [polypeptide binding]; other site 373384006907 catalytic residue [active] 373384006908 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 373384006909 GAF domain; Region: GAF; pfam01590 373384006910 Histidine kinase; Region: His_kinase; pfam06580 373384006911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384006912 ATP binding site [chemical binding]; other site 373384006913 Mg2+ binding site [ion binding]; other site 373384006914 G-X-G motif; other site 373384006915 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 373384006916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384006917 active site 373384006918 phosphorylation site [posttranslational modification] 373384006919 intermolecular recognition site; other site 373384006920 dimerization interface [polypeptide binding]; other site 373384006921 LytTr DNA-binding domain; Region: LytTR; pfam04397 373384006922 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373384006923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384006924 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373384006925 dimerization domain swap beta strand [polypeptide binding]; other site 373384006926 regulatory protein interface [polypeptide binding]; other site 373384006927 active site 373384006928 regulatory phosphorylation site [posttranslational modification]; other site 373384006929 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 373384006930 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 373384006931 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373384006932 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 373384006933 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 373384006934 active site 373384006935 phosphorylation site [posttranslational modification] 373384006936 exoaminopeptidase; Provisional; Region: PRK09961 373384006937 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 373384006938 oligomer interface [polypeptide binding]; other site 373384006939 active site 373384006940 metal binding site [ion binding]; metal-binding site 373384006941 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 373384006942 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 373384006943 active site 373384006944 P-loop; other site 373384006945 phosphorylation site [posttranslational modification] 373384006946 glucokinase, proteobacterial type; Region: glk; TIGR00749 373384006947 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373384006948 nucleotide binding site [chemical binding]; other site 373384006949 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 373384006950 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 373384006951 Cl- selectivity filter; other site 373384006952 Cl- binding residues [ion binding]; other site 373384006953 pore gating glutamate residue; other site 373384006954 dimer interface [polypeptide binding]; other site 373384006955 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 373384006956 manganese transport protein MntH; Reviewed; Region: PRK00701 373384006957 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 373384006958 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 373384006959 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 373384006960 Nucleoside recognition; Region: Gate; pfam07670 373384006961 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 373384006962 MASE1; Region: MASE1; pfam05231 373384006963 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373384006964 diguanylate cyclase; Region: GGDEF; smart00267 373384006965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384006966 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 373384006967 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 373384006968 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 373384006969 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373384006970 active site 373384006971 HIGH motif; other site 373384006972 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 373384006973 active site 373384006974 KMSKS motif; other site 373384006975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373384006976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384006977 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 373384006978 putative dimerization interface [polypeptide binding]; other site 373384006979 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 373384006980 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 373384006981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 373384006982 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 373384006983 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 373384006984 nucleotide binding pocket [chemical binding]; other site 373384006985 K-X-D-G motif; other site 373384006986 catalytic site [active] 373384006987 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 373384006988 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 373384006989 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 373384006990 Dimer interface [polypeptide binding]; other site 373384006991 BRCT sequence motif; other site 373384006992 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 373384006993 cell division protein ZipA; Provisional; Region: PRK03427 373384006994 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 373384006995 FtsZ protein binding site [polypeptide binding]; other site 373384006996 putative sulfate transport protein CysZ; Validated; Region: PRK04949 373384006997 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 373384006998 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 373384006999 dimer interface [polypeptide binding]; other site 373384007000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384007001 catalytic residue [active] 373384007002 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373384007003 dimerization domain swap beta strand [polypeptide binding]; other site 373384007004 regulatory protein interface [polypeptide binding]; other site 373384007005 active site 373384007006 regulatory phosphorylation site [posttranslational modification]; other site 373384007007 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 373384007008 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 373384007009 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373384007010 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 373384007011 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 373384007012 HPr interaction site; other site 373384007013 glycerol kinase (GK) interaction site [polypeptide binding]; other site 373384007014 active site 373384007015 phosphorylation site [posttranslational modification] 373384007016 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 373384007017 dimer interface [polypeptide binding]; other site 373384007018 pyridoxamine kinase; Validated; Region: PRK05756 373384007019 pyridoxal binding site [chemical binding]; other site 373384007020 ATP binding site [chemical binding]; other site 373384007021 hypothetical protein; Provisional; Region: PRK10318 373384007022 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 373384007023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 373384007024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 373384007025 cysteine synthase B; Region: cysM; TIGR01138 373384007026 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 373384007027 dimer interface [polypeptide binding]; other site 373384007028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384007029 catalytic residue [active] 373384007030 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 373384007031 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 373384007032 Walker A/P-loop; other site 373384007033 ATP binding site [chemical binding]; other site 373384007034 Q-loop/lid; other site 373384007035 ABC transporter signature motif; other site 373384007036 Walker B; other site 373384007037 D-loop; other site 373384007038 H-loop/switch region; other site 373384007039 TOBE-like domain; Region: TOBE_3; pfam12857 373384007040 sulfate transport protein; Provisional; Region: cysT; CHL00187 373384007041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384007042 dimer interface [polypeptide binding]; other site 373384007043 conserved gate region; other site 373384007044 putative PBP binding loops; other site 373384007045 ABC-ATPase subunit interface; other site 373384007046 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 373384007047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384007048 dimer interface [polypeptide binding]; other site 373384007049 conserved gate region; other site 373384007050 putative PBP binding loops; other site 373384007051 ABC-ATPase subunit interface; other site 373384007052 thiosulfate transporter subunit; Provisional; Region: PRK10852 373384007053 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 373384007054 short chain dehydrogenase; Provisional; Region: PRK08226 373384007055 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 373384007056 NAD binding site [chemical binding]; other site 373384007057 homotetramer interface [polypeptide binding]; other site 373384007058 homodimer interface [polypeptide binding]; other site 373384007059 active site 373384007060 transcriptional regulator MurR; Provisional; Region: PRK15482 373384007061 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 373384007062 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 373384007063 putative active site [active] 373384007064 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 373384007065 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 373384007066 putative active site [active] 373384007067 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 373384007068 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 373384007069 active site turn [active] 373384007070 phosphorylation site [posttranslational modification] 373384007071 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 373384007072 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 373384007073 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 373384007074 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 373384007075 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 373384007076 putative acetyltransferase; Provisional; Region: PRK03624 373384007077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384007078 Coenzyme A binding pocket [chemical binding]; other site 373384007079 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 373384007080 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373384007081 active site 373384007082 metal binding site [ion binding]; metal-binding site 373384007083 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 373384007084 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 373384007085 transcriptional regulator EutR; Provisional; Region: PRK10130 373384007086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384007087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384007088 carboxysome structural protein EutK; Provisional; Region: PRK15466 373384007089 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 373384007090 Hexamer interface [polypeptide binding]; other site 373384007091 Hexagonal pore residue; other site 373384007092 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 373384007093 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 373384007094 putative hexamer interface [polypeptide binding]; other site 373384007095 putative hexagonal pore; other site 373384007096 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 373384007097 putative hexamer interface [polypeptide binding]; other site 373384007098 putative hexagonal pore; other site 373384007099 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 373384007100 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384007101 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373384007102 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 373384007103 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 373384007104 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384007105 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384007106 HTH-like domain; Region: HTH_21; pfam13276 373384007107 Integrase core domain; Region: rve; pfam00665 373384007108 Integrase core domain; Region: rve_3; pfam13683 373384007109 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384007110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007111 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 373384007112 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 373384007113 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 373384007114 G1 box; other site 373384007115 GTP/Mg2+ binding site [chemical binding]; other site 373384007116 G2 box; other site 373384007117 Switch I region; other site 373384007118 G3 box; other site 373384007119 Switch II region; other site 373384007120 G4 box; other site 373384007121 G5 box; other site 373384007122 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 373384007123 putative hexamer interface [polypeptide binding]; other site 373384007124 putative hexagonal pore; other site 373384007125 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 373384007126 Malic enzyme, N-terminal domain; Region: malic; pfam00390 373384007127 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 373384007128 putative NAD(P) binding site [chemical binding]; other site 373384007129 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 373384007130 transaldolase-like protein; Provisional; Region: PTZ00411 373384007131 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 373384007132 active site 373384007133 dimer interface [polypeptide binding]; other site 373384007134 catalytic residue [active] 373384007135 transketolase; Reviewed; Region: PRK12753 373384007136 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 373384007137 TPP-binding site [chemical binding]; other site 373384007138 dimer interface [polypeptide binding]; other site 373384007139 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373384007140 PYR/PP interface [polypeptide binding]; other site 373384007141 dimer interface [polypeptide binding]; other site 373384007142 TPP binding site [chemical binding]; other site 373384007143 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373384007144 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 373384007145 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 373384007146 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 373384007147 dimer interface [polypeptide binding]; other site 373384007148 ADP-ribose binding site [chemical binding]; other site 373384007149 active site 373384007150 nudix motif; other site 373384007151 metal binding site [ion binding]; metal-binding site 373384007152 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 373384007153 4Fe-4S binding domain; Region: Fer4; pfam00037 373384007154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 373384007155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384007156 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 373384007157 Protein export membrane protein; Region: SecD_SecF; cl14618 373384007158 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 373384007159 ArsC family; Region: ArsC; pfam03960 373384007160 putative catalytic residues [active] 373384007161 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 373384007162 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 373384007163 metal binding site [ion binding]; metal-binding site 373384007164 dimer interface [polypeptide binding]; other site 373384007165 hypothetical protein; Provisional; Region: PRK13664 373384007166 putative hydrolase; Provisional; Region: PRK11460 373384007167 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 373384007168 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 373384007169 Helicase; Region: Helicase_RecD; pfam05127 373384007170 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 373384007171 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 373384007172 Predicted metalloprotease [General function prediction only]; Region: COG2321 373384007173 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 373384007174 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 373384007175 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 373384007176 ATP binding site [chemical binding]; other site 373384007177 active site 373384007178 substrate binding site [chemical binding]; other site 373384007179 lipoprotein; Provisional; Region: PRK11679 373384007180 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 373384007181 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 373384007182 dihydrodipicolinate synthase; Region: dapA; TIGR00674 373384007183 dimer interface [polypeptide binding]; other site 373384007184 active site 373384007185 catalytic residue [active] 373384007186 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 373384007187 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 373384007188 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 373384007189 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 373384007190 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 373384007191 catalytic triad [active] 373384007192 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 373384007193 4Fe-4S binding domain; Region: Fer4; pfam00037 373384007194 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 373384007195 NADH dehydrogenase; Region: NADHdh; cl00469 373384007196 hydrogenase 4 subunit D; Validated; Region: PRK06525 373384007197 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373384007198 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 373384007199 hydrogenase 4 subunit F; Validated; Region: PRK06458 373384007200 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373384007201 hydrogenase 4 subunit H; Validated; Region: PRK08222 373384007202 4Fe-4S binding domain; Region: Fer4; pfam00037 373384007203 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 373384007204 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 373384007205 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 373384007206 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373384007207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384007208 Walker A motif; other site 373384007209 ATP binding site [chemical binding]; other site 373384007210 Walker B motif; other site 373384007211 arginine finger; other site 373384007212 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 373384007213 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 373384007214 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373384007215 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 373384007216 Peptidase family M48; Region: Peptidase_M48; cl12018 373384007217 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 373384007218 ArsC family; Region: ArsC; pfam03960 373384007219 catalytic residues [active] 373384007220 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 373384007221 DNA replication initiation factor; Provisional; Region: PRK08084 373384007222 uracil transporter; Provisional; Region: PRK10720 373384007223 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384007224 active site 373384007225 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 373384007226 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 373384007227 dimerization interface [polypeptide binding]; other site 373384007228 putative ATP binding site [chemical binding]; other site 373384007229 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 373384007230 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 373384007231 active site 373384007232 substrate binding site [chemical binding]; other site 373384007233 cosubstrate binding site; other site 373384007234 catalytic site [active] 373384007235 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 373384007236 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 373384007237 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 373384007238 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 373384007239 domain interface [polypeptide binding]; other site 373384007240 active site 373384007241 catalytic site [active] 373384007242 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 373384007243 putative active site [active] 373384007244 catalytic site [active] 373384007245 exopolyphosphatase; Provisional; Region: PRK10854 373384007246 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 373384007247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007248 Transposase; Region: HTH_Tnp_1; pfam01527 373384007249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384007250 Integrase core domain; Region: rve; pfam00665 373384007251 Integrase core domain; Region: rve_3; pfam13683 373384007252 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 373384007253 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 373384007254 GMP synthase; Reviewed; Region: guaA; PRK00074 373384007255 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 373384007256 AMP/PPi binding site [chemical binding]; other site 373384007257 candidate oxyanion hole; other site 373384007258 catalytic triad [active] 373384007259 potential glutamine specificity residues [chemical binding]; other site 373384007260 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 373384007261 ATP Binding subdomain [chemical binding]; other site 373384007262 Ligand Binding sites [chemical binding]; other site 373384007263 Dimerization subdomain; other site 373384007264 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 373384007265 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 373384007266 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 373384007267 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 373384007268 active site 373384007269 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 373384007270 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 373384007271 generic binding surface II; other site 373384007272 generic binding surface I; other site 373384007273 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 373384007274 GTP-binding protein Der; Reviewed; Region: PRK00093 373384007275 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 373384007276 G1 box; other site 373384007277 GTP/Mg2+ binding site [chemical binding]; other site 373384007278 Switch I region; other site 373384007279 G2 box; other site 373384007280 Switch II region; other site 373384007281 G3 box; other site 373384007282 G4 box; other site 373384007283 G5 box; other site 373384007284 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 373384007285 G1 box; other site 373384007286 GTP/Mg2+ binding site [chemical binding]; other site 373384007287 Switch I region; other site 373384007288 G2 box; other site 373384007289 G3 box; other site 373384007290 Switch II region; other site 373384007291 G4 box; other site 373384007292 G5 box; other site 373384007293 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 373384007294 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 373384007295 Trp docking motif [polypeptide binding]; other site 373384007296 active site 373384007297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 373384007298 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 373384007299 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 373384007300 dimer interface [polypeptide binding]; other site 373384007301 motif 1; other site 373384007302 active site 373384007303 motif 2; other site 373384007304 motif 3; other site 373384007305 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 373384007306 anticodon binding site; other site 373384007307 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 373384007308 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 373384007309 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 373384007310 cytoskeletal protein RodZ; Provisional; Region: PRK10856 373384007311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384007312 non-specific DNA binding site [nucleotide binding]; other site 373384007313 salt bridge; other site 373384007314 sequence-specific DNA binding site [nucleotide binding]; other site 373384007315 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 373384007316 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 373384007317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384007318 FeS/SAM binding site; other site 373384007319 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 373384007320 active site 373384007321 multimer interface [polypeptide binding]; other site 373384007322 Transglycosylase; Region: Transgly; pfam00912 373384007323 penicillin-binding protein 1C; Provisional; Region: PRK11240 373384007324 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 373384007325 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 373384007326 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 373384007327 Transposase; Region: DEDD_Tnp_IS110; pfam01548 373384007328 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 373384007329 aminopeptidase B; Provisional; Region: PRK05015 373384007330 Peptidase; Region: DUF3663; pfam12404 373384007331 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 373384007332 interface (dimer of trimers) [polypeptide binding]; other site 373384007333 Substrate-binding/catalytic site; other site 373384007334 Zn-binding sites [ion binding]; other site 373384007335 hypothetical protein; Provisional; Region: PRK10721 373384007336 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 373384007337 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373384007338 catalytic loop [active] 373384007339 iron binding site [ion binding]; other site 373384007340 chaperone protein HscA; Provisional; Region: hscA; PRK05183 373384007341 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 373384007342 nucleotide binding site [chemical binding]; other site 373384007343 putative NEF/HSP70 interaction site [polypeptide binding]; other site 373384007344 SBD interface [polypeptide binding]; other site 373384007345 co-chaperone HscB; Provisional; Region: hscB; PRK05014 373384007346 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 373384007347 HSP70 interaction site [polypeptide binding]; other site 373384007348 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 373384007349 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 373384007350 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 373384007351 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 373384007352 trimerization site [polypeptide binding]; other site 373384007353 active site 373384007354 cysteine desulfurase; Provisional; Region: PRK14012 373384007355 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 373384007356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373384007357 catalytic residue [active] 373384007358 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 373384007359 Rrf2 family protein; Region: rrf2_super; TIGR00738 373384007360 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 373384007361 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 373384007362 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 373384007363 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 373384007364 active site 373384007365 dimerization interface [polypeptide binding]; other site 373384007366 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 373384007367 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373384007368 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 373384007369 PRD domain; Region: PRD; pfam00874 373384007370 PRD domain; Region: PRD; pfam00874 373384007371 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 373384007372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384007373 putative substrate translocation pore; other site 373384007374 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 373384007375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384007376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384007377 dimerization interface [polypeptide binding]; other site 373384007378 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 373384007379 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 373384007380 iron-sulfur cluster [ion binding]; other site 373384007381 [2Fe-2S] cluster binding site [ion binding]; other site 373384007382 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 373384007383 beta subunit interface [polypeptide binding]; other site 373384007384 alpha subunit interface [polypeptide binding]; other site 373384007385 active site 373384007386 substrate binding site [chemical binding]; other site 373384007387 Fe binding site [ion binding]; other site 373384007388 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 373384007389 inter-subunit interface; other site 373384007390 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 373384007391 [2Fe-2S] cluster binding site [ion binding]; other site 373384007392 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 373384007393 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 373384007394 NAD binding site [chemical binding]; other site 373384007395 active site 373384007396 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 373384007397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384007398 Predicted membrane protein [Function unknown]; Region: COG2259 373384007399 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 373384007400 active site 373384007401 catalytic residues [active] 373384007402 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373384007403 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 373384007404 putative NAD(P) binding site [chemical binding]; other site 373384007405 catalytic Zn binding site [ion binding]; other site 373384007406 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384007407 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384007408 TM-ABC transporter signature motif; other site 373384007409 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 373384007410 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373384007411 Walker A/P-loop; other site 373384007412 ATP binding site [chemical binding]; other site 373384007413 Q-loop/lid; other site 373384007414 ABC transporter signature motif; other site 373384007415 Walker B; other site 373384007416 D-loop; other site 373384007417 H-loop/switch region; other site 373384007418 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 373384007419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 373384007420 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 373384007421 ligand binding site [chemical binding]; other site 373384007422 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 373384007423 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 373384007424 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373384007425 nucleotide binding site [chemical binding]; other site 373384007426 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 373384007427 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 373384007428 dimer interface [polypeptide binding]; other site 373384007429 active site 373384007430 glycine-pyridoxal phosphate binding site [chemical binding]; other site 373384007431 folate binding site [chemical binding]; other site 373384007432 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 373384007433 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 373384007434 heme-binding site [chemical binding]; other site 373384007435 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 373384007436 FAD binding pocket [chemical binding]; other site 373384007437 FAD binding motif [chemical binding]; other site 373384007438 phosphate binding motif [ion binding]; other site 373384007439 beta-alpha-beta structure motif; other site 373384007440 NAD binding pocket [chemical binding]; other site 373384007441 Heme binding pocket [chemical binding]; other site 373384007442 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 373384007443 Nitrogen regulatory protein P-II; Region: P-II; smart00938 373384007444 response regulator GlrR; Provisional; Region: PRK15115 373384007445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384007446 active site 373384007447 phosphorylation site [posttranslational modification] 373384007448 intermolecular recognition site; other site 373384007449 dimerization interface [polypeptide binding]; other site 373384007450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384007451 Walker A motif; other site 373384007452 ATP binding site [chemical binding]; other site 373384007453 Walker B motif; other site 373384007454 arginine finger; other site 373384007455 hypothetical protein; Provisional; Region: PRK10722 373384007456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 373384007457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384007458 dimer interface [polypeptide binding]; other site 373384007459 phosphorylation site [posttranslational modification] 373384007460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384007461 ATP binding site [chemical binding]; other site 373384007462 Mg2+ binding site [ion binding]; other site 373384007463 G-X-G motif; other site 373384007464 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 373384007465 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 373384007466 dimerization interface [polypeptide binding]; other site 373384007467 ATP binding site [chemical binding]; other site 373384007468 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 373384007469 dimerization interface [polypeptide binding]; other site 373384007470 ATP binding site [chemical binding]; other site 373384007471 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 373384007472 putative active site [active] 373384007473 catalytic triad [active] 373384007474 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 373384007475 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384007476 substrate binding pocket [chemical binding]; other site 373384007477 membrane-bound complex binding site; other site 373384007478 hinge residues; other site 373384007479 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373384007480 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373384007481 catalytic residue [active] 373384007482 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 373384007483 nucleoside/Zn binding site; other site 373384007484 dimer interface [polypeptide binding]; other site 373384007485 catalytic motif [active] 373384007486 hypothetical protein; Provisional; Region: PRK11590 373384007487 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 373384007488 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 373384007489 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 373384007490 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 373384007491 putative active site [active] 373384007492 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 373384007493 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 373384007494 catalytic residues [active] 373384007495 catalytic nucleophile [active] 373384007496 Presynaptic Site I dimer interface [polypeptide binding]; other site 373384007497 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 373384007498 Synaptic Flat tetramer interface [polypeptide binding]; other site 373384007499 Synaptic Site I dimer interface [polypeptide binding]; other site 373384007500 DNA binding site [nucleotide binding] 373384007501 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 373384007502 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 373384007503 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384007504 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 373384007505 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 373384007506 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 373384007507 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384007508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007509 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384007510 HTH-like domain; Region: HTH_21; pfam13276 373384007511 Integrase core domain; Region: rve; pfam00665 373384007512 Integrase core domain; Region: rve_3; pfam13683 373384007513 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 373384007514 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 373384007515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007516 Transposase; Region: HTH_Tnp_1; pfam01527 373384007517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384007518 Integrase core domain; Region: rve; pfam00665 373384007519 Integrase core domain; Region: rve_3; pfam13683 373384007520 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384007521 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384007522 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 373384007523 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 373384007524 active site 373384007525 hydrophilic channel; other site 373384007526 dimerization interface [polypeptide binding]; other site 373384007527 catalytic residues [active] 373384007528 active site lid [active] 373384007529 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 373384007530 Recombination protein O N terminal; Region: RecO_N; pfam11967 373384007531 Recombination protein O C terminal; Region: RecO_C; pfam02565 373384007532 GTPase Era; Reviewed; Region: era; PRK00089 373384007533 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 373384007534 G1 box; other site 373384007535 GTP/Mg2+ binding site [chemical binding]; other site 373384007536 Switch I region; other site 373384007537 G2 box; other site 373384007538 Switch II region; other site 373384007539 G3 box; other site 373384007540 G4 box; other site 373384007541 G5 box; other site 373384007542 KH domain; Region: KH_2; pfam07650 373384007543 ribonuclease III; Reviewed; Region: rnc; PRK00102 373384007544 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 373384007545 dimerization interface [polypeptide binding]; other site 373384007546 active site 373384007547 metal binding site [ion binding]; metal-binding site 373384007548 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 373384007549 dsRNA binding site [nucleotide binding]; other site 373384007550 signal peptidase I; Provisional; Region: PRK10861 373384007551 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 373384007552 Catalytic site [active] 373384007553 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 373384007554 GTP-binding protein LepA; Provisional; Region: PRK05433 373384007555 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 373384007556 G1 box; other site 373384007557 putative GEF interaction site [polypeptide binding]; other site 373384007558 GTP/Mg2+ binding site [chemical binding]; other site 373384007559 Switch I region; other site 373384007560 G2 box; other site 373384007561 G3 box; other site 373384007562 Switch II region; other site 373384007563 G4 box; other site 373384007564 G5 box; other site 373384007565 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 373384007566 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 373384007567 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 373384007568 SoxR reducing system protein RseC; Provisional; Region: PRK10862 373384007569 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 373384007570 anti-sigma E factor; Provisional; Region: rseB; PRK09455 373384007571 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 373384007572 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 373384007573 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 373384007574 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 373384007575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373384007576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373384007577 DNA binding residues [nucleotide binding] 373384007578 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 373384007579 Methyltransferase domain; Region: Methyltransf_26; pfam13659 373384007580 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 373384007581 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 373384007582 ATP binding site [chemical binding]; other site 373384007583 Mg++ binding site [ion binding]; other site 373384007584 motif III; other site 373384007585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384007586 nucleotide binding region [chemical binding]; other site 373384007587 ATP-binding site [chemical binding]; other site 373384007588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373384007589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384007590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 373384007591 dimerization interface [polypeptide binding]; other site 373384007592 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 373384007593 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 373384007594 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 373384007595 ligand binding site [chemical binding]; other site 373384007596 active site 373384007597 UGI interface [polypeptide binding]; other site 373384007598 catalytic site [active] 373384007599 putative methyltransferase; Provisional; Region: PRK10864 373384007600 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 373384007601 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 373384007602 thioredoxin 2; Provisional; Region: PRK10996 373384007603 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 373384007604 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373384007605 catalytic residues [active] 373384007606 Uncharacterized conserved protein [Function unknown]; Region: COG3148 373384007607 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 373384007608 CoA binding domain; Region: CoA_binding_2; pfam13380 373384007609 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 373384007610 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 373384007611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 373384007612 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 373384007613 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 373384007614 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 373384007615 domain interface [polypeptide binding]; other site 373384007616 putative active site [active] 373384007617 catalytic site [active] 373384007618 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 373384007619 domain interface [polypeptide binding]; other site 373384007620 putative active site [active] 373384007621 catalytic site [active] 373384007622 lipoprotein; Provisional; Region: PRK10759 373384007623 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 373384007624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384007625 putative substrate translocation pore; other site 373384007626 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384007627 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384007628 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384007629 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384007630 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384007631 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 373384007632 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 373384007633 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 373384007634 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384007635 RNA binding surface [nucleotide binding]; other site 373384007636 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 373384007637 active site 373384007638 hypothetical protein; Provisional; Region: PRK10723 373384007639 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 373384007640 protein disaggregation chaperone; Provisional; Region: PRK10865 373384007641 Clp amino terminal domain; Region: Clp_N; pfam02861 373384007642 Clp amino terminal domain; Region: Clp_N; pfam02861 373384007643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384007644 Walker A motif; other site 373384007645 ATP binding site [chemical binding]; other site 373384007646 Walker B motif; other site 373384007647 arginine finger; other site 373384007648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384007649 Walker A motif; other site 373384007650 ATP binding site [chemical binding]; other site 373384007651 Walker B motif; other site 373384007652 arginine finger; other site 373384007653 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 373384007654 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384007655 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384007656 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384007657 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 373384007658 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 373384007659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 373384007660 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 373384007661 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 373384007662 SecY interacting protein Syd; Provisional; Region: PRK04968 373384007663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 373384007664 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 373384007665 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 373384007666 probable active site [active] 373384007667 flavodoxin; Provisional; Region: PRK08105 373384007668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384007669 D-galactonate transporter; Region: 2A0114; TIGR00893 373384007670 putative substrate translocation pore; other site 373384007671 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 373384007672 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 373384007673 active site 373384007674 tetramer interface [polypeptide binding]; other site 373384007675 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 373384007676 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 373384007677 active site 373384007678 tetramer interface [polypeptide binding]; other site 373384007679 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 373384007680 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 373384007681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384007682 dimerization interface [polypeptide binding]; other site 373384007683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384007684 dimer interface [polypeptide binding]; other site 373384007685 phosphorylation site [posttranslational modification] 373384007686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384007687 ATP binding site [chemical binding]; other site 373384007688 Mg2+ binding site [ion binding]; other site 373384007689 G-X-G motif; other site 373384007690 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 373384007691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384007692 active site 373384007693 phosphorylation site [posttranslational modification] 373384007694 intermolecular recognition site; other site 373384007695 dimerization interface [polypeptide binding]; other site 373384007696 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373384007697 putative binding surface; other site 373384007698 active site 373384007699 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 373384007700 TRAM domain; Region: TRAM; pfam01938 373384007701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384007702 S-adenosylmethionine binding site [chemical binding]; other site 373384007703 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 373384007704 HD domain; Region: HD_4; pfam13328 373384007705 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 373384007706 synthetase active site [active] 373384007707 NTP binding site [chemical binding]; other site 373384007708 metal binding site [ion binding]; metal-binding site 373384007709 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 373384007710 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 373384007711 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 373384007712 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 373384007713 homodimer interface [polypeptide binding]; other site 373384007714 metal binding site [ion binding]; metal-binding site 373384007715 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 373384007716 homodimer interface [polypeptide binding]; other site 373384007717 active site 373384007718 putative chemical substrate binding site [chemical binding]; other site 373384007719 metal binding site [ion binding]; metal-binding site 373384007720 CTP synthetase; Validated; Region: pyrG; PRK05380 373384007721 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 373384007722 Catalytic site [active] 373384007723 active site 373384007724 UTP binding site [chemical binding]; other site 373384007725 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 373384007726 active site 373384007727 putative oxyanion hole; other site 373384007728 catalytic triad [active] 373384007729 enolase; Provisional; Region: eno; PRK00077 373384007730 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 373384007731 dimer interface [polypeptide binding]; other site 373384007732 metal binding site [ion binding]; metal-binding site 373384007733 substrate binding pocket [chemical binding]; other site 373384007734 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 373384007735 Repair protein; Region: Repair_PSII; pfam04536 373384007736 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 373384007737 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 373384007738 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384007739 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384007740 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 373384007741 benzoate transport; Region: 2A0115; TIGR00895 373384007742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384007743 putative substrate translocation pore; other site 373384007744 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 373384007745 Ligand binding site [chemical binding]; other site 373384007746 Electron transfer flavoprotein domain; Region: ETF; pfam01012 373384007747 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 373384007748 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 373384007749 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 373384007750 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 373384007751 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 373384007752 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 373384007753 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384007754 HTH-like domain; Region: HTH_21; pfam13276 373384007755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384007756 Integrase core domain; Region: rve; pfam00665 373384007757 Integrase core domain; Region: rve_3; pfam13683 373384007758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007759 Transposase; Region: HTH_Tnp_1; pfam01527 373384007760 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 373384007761 active site 373384007762 metal binding site [ion binding]; metal-binding site 373384007763 interdomain interaction site; other site 373384007764 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 373384007765 Homing endonuclease; Region: Hom_end; pfam05204 373384007766 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 373384007767 ATP binding site [chemical binding]; other site 373384007768 AAA domain; Region: AAA_25; pfam13481 373384007769 Walker B motif; other site 373384007770 NinB protein; Region: NinB; pfam05772 373384007771 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 373384007772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384007773 salt bridge; other site 373384007774 non-specific DNA binding site [nucleotide binding]; other site 373384007775 sequence-specific DNA binding site [nucleotide binding]; other site 373384007776 Ash protein family; Region: Phage_ASH; pfam10554 373384007777 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 373384007778 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 373384007779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384007780 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 373384007781 Walker A motif; other site 373384007782 ATP binding site [chemical binding]; other site 373384007783 Walker B motif; other site 373384007784 arginine finger; other site 373384007785 replicative DNA helicase; Region: DnaB; TIGR00665 373384007786 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 373384007787 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 373384007788 Walker A motif; other site 373384007789 ATP binding site [chemical binding]; other site 373384007790 Walker B motif; other site 373384007791 DNA binding loops [nucleotide binding] 373384007792 Phage NinH protein; Region: Phage_NinH; pfam06322 373384007793 Lysis protein S; Region: Lysis_S; pfam04971 373384007794 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 373384007795 catalytic residues [active] 373384007796 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 373384007797 HTH-like domain; Region: HTH_21; pfam13276 373384007798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384007799 Integrase core domain; Region: rve; pfam00665 373384007800 Integrase core domain; Region: rve_3; pfam13683 373384007801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007802 Transposase; Region: HTH_Tnp_1; pfam01527 373384007803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007804 Transposase; Region: HTH_Tnp_1; cl17663 373384007805 putative transposase OrfB; Reviewed; Region: PHA02517 373384007806 HTH-like domain; Region: HTH_21; pfam13276 373384007807 Integrase core domain; Region: rve; pfam00665 373384007808 Integrase core domain; Region: rve_3; pfam13683 373384007809 Transposase; Region: HTH_Tnp_1; cl17663 373384007810 HTH-like domain; Region: HTH_21; pfam13276 373384007811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384007812 Integrase core domain; Region: rve; pfam00665 373384007813 Integrase core domain; Region: rve_3; pfam13683 373384007814 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 373384007815 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 373384007816 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 373384007817 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 373384007818 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 373384007819 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 373384007820 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 373384007821 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 373384007822 tandem repeat interface [polypeptide binding]; other site 373384007823 oligomer interface [polypeptide binding]; other site 373384007824 active site residues [active] 373384007825 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 373384007826 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 373384007827 DNA packaging protein FI; Region: Packaging_FI; pfam14000 373384007828 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 373384007829 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 373384007830 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 373384007831 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 373384007832 Bacterial Ig-like domain 2; Region: BID_2; smart00635 373384007833 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 373384007834 Minor tail protein T; Region: Phage_tail_T; pfam06223 373384007835 Phage minor tail protein; Region: Phage_min_tail; cl01940 373384007836 Phage-related protein [Function unknown]; Region: gp18; COG4672 373384007837 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 373384007838 MPN+ (JAMM) motif; other site 373384007839 Zinc-binding site [ion binding]; other site 373384007840 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 373384007841 NlpC/P60 family; Region: NLPC_P60; cl17555 373384007842 Phage-related protein, tail component [Function unknown]; Region: COG4723 373384007843 Phage-related protein, tail component [Function unknown]; Region: COG4733 373384007844 Putative phage tail protein; Region: Phage-tail_3; pfam13550 373384007845 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 373384007846 Interdomain contacts; other site 373384007847 Cytokine receptor motif; other site 373384007848 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 373384007849 Fibronectin type III protein; Region: DUF3672; pfam12421 373384007850 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 373384007851 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 373384007852 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 373384007853 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 373384007854 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 373384007855 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 373384007856 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 373384007857 putative oxidoreductase FixC; Provisional; Region: PRK10157 373384007858 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 373384007859 homohexamer interface [polypeptide binding]; other site 373384007860 putative substrate stabilizing pore; other site 373384007861 pterin binding site; other site 373384007862 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 373384007863 Flavodoxin; Region: Flavodoxin_1; pfam00258 373384007864 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 373384007865 FAD binding pocket [chemical binding]; other site 373384007866 FAD binding motif [chemical binding]; other site 373384007867 catalytic residues [active] 373384007868 NAD binding pocket [chemical binding]; other site 373384007869 phosphate binding motif [ion binding]; other site 373384007870 beta-alpha-beta structure motif; other site 373384007871 sulfite reductase subunit beta; Provisional; Region: PRK13504 373384007872 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 373384007873 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 373384007874 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 373384007875 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 373384007876 Active Sites [active] 373384007877 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 373384007878 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 373384007879 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 373384007880 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 373384007881 metal binding site [ion binding]; metal-binding site 373384007882 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 373384007883 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 373384007884 Active Sites [active] 373384007885 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 373384007886 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 373384007887 CysD dimerization site [polypeptide binding]; other site 373384007888 G1 box; other site 373384007889 putative GEF interaction site [polypeptide binding]; other site 373384007890 GTP/Mg2+ binding site [chemical binding]; other site 373384007891 Switch I region; other site 373384007892 G2 box; other site 373384007893 G3 box; other site 373384007894 Switch II region; other site 373384007895 G4 box; other site 373384007896 G5 box; other site 373384007897 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 373384007898 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 373384007899 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 373384007900 ligand-binding site [chemical binding]; other site 373384007901 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 373384007902 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 373384007903 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 373384007904 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 373384007905 substrate binding site; other site 373384007906 dimer interface; other site 373384007907 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 373384007908 homotrimer interaction site [polypeptide binding]; other site 373384007909 zinc binding site [ion binding]; other site 373384007910 CDP-binding sites; other site 373384007911 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 373384007912 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 373384007913 Permutation of conserved domain; other site 373384007914 active site 373384007915 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 373384007916 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 373384007917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384007918 S-adenosylmethionine binding site [chemical binding]; other site 373384007919 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 373384007920 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384007921 Peptidase family M23; Region: Peptidase_M23; pfam01551 373384007922 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 373384007923 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373384007924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373384007925 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373384007926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373384007927 DNA binding residues [nucleotide binding] 373384007928 MarR family; Region: MarR_2; cl17246 373384007929 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 373384007930 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 373384007931 Flavoprotein; Region: Flavoprotein; pfam02441 373384007932 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 373384007933 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 373384007934 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 373384007935 Integrase core domain; Region: rve; pfam00665 373384007936 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 373384007937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384007938 Integrase core domain; Region: rve; pfam00665 373384007939 Integrase core domain; Region: rve_3; pfam13683 373384007940 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384007941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384007942 Transposase; Region: HTH_Tnp_1; pfam01527 373384007943 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 373384007944 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 373384007945 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 373384007946 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 373384007947 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384007948 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 373384007949 MutS domain I; Region: MutS_I; pfam01624 373384007950 MutS domain II; Region: MutS_II; pfam05188 373384007951 MutS domain III; Region: MutS_III; pfam05192 373384007952 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 373384007953 Walker A/P-loop; other site 373384007954 ATP binding site [chemical binding]; other site 373384007955 Q-loop/lid; other site 373384007956 ABC transporter signature motif; other site 373384007957 Walker B; other site 373384007958 D-loop; other site 373384007959 H-loop/switch region; other site 373384007960 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 373384007961 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 373384007962 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373384007963 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373384007964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384007965 Walker A motif; other site 373384007966 ATP binding site [chemical binding]; other site 373384007967 Walker B motif; other site 373384007968 arginine finger; other site 373384007969 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 373384007970 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 373384007971 dimerization interface [polypeptide binding]; other site 373384007972 ATP binding site [chemical binding]; other site 373384007973 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 373384007974 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 373384007975 hydrogenase assembly chaperone; Provisional; Region: PRK10409 373384007976 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 373384007977 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 373384007978 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 373384007979 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 373384007980 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 373384007981 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 373384007982 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 373384007983 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 373384007984 NADH dehydrogenase; Region: NADHdh; cl00469 373384007985 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 373384007986 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 373384007987 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 373384007988 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 373384007989 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384007990 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 373384007991 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 373384007992 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 373384007993 nickel binding site [ion binding]; other site 373384007994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384007995 non-specific DNA binding site [nucleotide binding]; other site 373384007996 salt bridge; other site 373384007997 sequence-specific DNA binding site [nucleotide binding]; other site 373384007998 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 373384007999 beta-galactosidase; Region: BGL; TIGR03356 373384008000 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 373384008001 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 373384008002 active site turn [active] 373384008003 phosphorylation site [posttranslational modification] 373384008004 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 373384008005 Transcriptional regulators [Transcription]; Region: PurR; COG1609 373384008006 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384008007 DNA binding site [nucleotide binding] 373384008008 domain linker motif; other site 373384008009 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 373384008010 dimerization interface (closed form) [polypeptide binding]; other site 373384008011 ligand binding site [chemical binding]; other site 373384008012 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 373384008013 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 373384008014 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 373384008015 Acylphosphatase; Region: Acylphosphatase; pfam00708 373384008016 HypF finger; Region: zf-HYPF; pfam07503 373384008017 HypF finger; Region: zf-HYPF; pfam07503 373384008018 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 373384008019 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 373384008020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373384008021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384008022 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 373384008023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 373384008024 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 373384008025 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 373384008026 iron binding site [ion binding]; other site 373384008027 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 373384008028 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373384008029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384008030 Walker A motif; other site 373384008031 ATP binding site [chemical binding]; other site 373384008032 Walker B motif; other site 373384008033 arginine finger; other site 373384008034 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 373384008035 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 373384008036 putative active site [active] 373384008037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 373384008038 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 373384008039 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 373384008040 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384008041 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 373384008042 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 373384008043 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 373384008044 putative NAD(P) binding site [chemical binding]; other site 373384008045 active site 373384008046 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 373384008047 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 373384008048 Transglycosylase SLT domain; Region: SLT_2; pfam13406 373384008049 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373384008050 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373384008051 hypothetical protein; Validated; Region: PRK03661 373384008052 recombinase A; Provisional; Region: recA; PRK09354 373384008053 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 373384008054 hexamer interface [polypeptide binding]; other site 373384008055 Walker A motif; other site 373384008056 ATP binding site [chemical binding]; other site 373384008057 Walker B motif; other site 373384008058 recombination regulator RecX; Reviewed; Region: recX; PRK00117 373384008059 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 373384008060 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 373384008061 motif 1; other site 373384008062 active site 373384008063 motif 2; other site 373384008064 motif 3; other site 373384008065 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 373384008066 DHHA1 domain; Region: DHHA1; pfam02272 373384008067 carbon storage regulator; Provisional; Region: PRK01712 373384008068 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 373384008069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384008070 motif II; other site 373384008071 Predicted membrane protein [Function unknown]; Region: COG1238 373384008072 glutamate--cysteine ligase; Provisional; Region: PRK02107 373384008073 S-ribosylhomocysteinase; Provisional; Region: PRK02260 373384008074 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 373384008075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008076 putative substrate translocation pore; other site 373384008077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008078 transcriptional repressor MprA; Provisional; Region: PRK10870 373384008079 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 373384008080 putative L-valine exporter; Provisional; Region: PRK10408 373384008081 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 373384008082 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 373384008083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008084 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 373384008085 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 373384008086 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 373384008087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384008088 dimer interface [polypeptide binding]; other site 373384008089 conserved gate region; other site 373384008090 putative PBP binding loops; other site 373384008091 ABC-ATPase subunit interface; other site 373384008092 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 373384008093 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 373384008094 Walker A/P-loop; other site 373384008095 ATP binding site [chemical binding]; other site 373384008096 Q-loop/lid; other site 373384008097 ABC transporter signature motif; other site 373384008098 Walker B; other site 373384008099 D-loop; other site 373384008100 H-loop/switch region; other site 373384008101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 373384008102 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 373384008103 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 373384008104 dimer interface [polypeptide binding]; other site 373384008105 putative radical transfer pathway; other site 373384008106 diiron center [ion binding]; other site 373384008107 tyrosyl radical; other site 373384008108 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 373384008109 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 373384008110 Class I ribonucleotide reductase; Region: RNR_I; cd01679 373384008111 active site 373384008112 dimer interface [polypeptide binding]; other site 373384008113 catalytic residues [active] 373384008114 effector binding site; other site 373384008115 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 373384008116 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 373384008117 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 373384008118 catalytic residues [active] 373384008119 hypothetical protein; Provisional; Region: PRK10132 373384008120 hypothetical protein; Provisional; Region: PRK10556 373384008121 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 373384008122 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 373384008123 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 373384008124 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 373384008125 active site residue [active] 373384008126 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 373384008127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384008128 dimerization interface [polypeptide binding]; other site 373384008129 putative DNA binding site [nucleotide binding]; other site 373384008130 putative Zn2+ binding site [ion binding]; other site 373384008131 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 373384008132 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 373384008133 bacterial OsmY and nodulation domain; Region: BON; smart00749 373384008134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384008135 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 373384008136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384008137 DNA-binding site [nucleotide binding]; DNA binding site 373384008138 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 373384008139 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 373384008140 TMPIT-like protein; Region: TMPIT; pfam07851 373384008141 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 373384008142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373384008143 inhibitor-cofactor binding pocket; inhibition site 373384008144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384008145 catalytic residue [active] 373384008146 Predicted dehydrogenase [General function prediction only]; Region: COG0579 373384008147 hydroxyglutarate oxidase; Provisional; Region: PRK11728 373384008148 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 373384008149 substrate binding pocket [chemical binding]; other site 373384008150 active site 373384008151 iron coordination sites [ion binding]; other site 373384008152 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 373384008153 active site 373384008154 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 373384008155 Ca binding site [ion binding]; other site 373384008156 catalytic site [active] 373384008157 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 373384008158 putative transposase OrfB; Reviewed; Region: PHA02517 373384008159 HTH-like domain; Region: HTH_21; pfam13276 373384008160 Integrase core domain; Region: rve; pfam00665 373384008161 Integrase core domain; Region: rve_2; pfam13333 373384008162 Transposase; Region: HTH_Tnp_1; cl17663 373384008163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384008164 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008165 integrase; Provisional; Region: PRK09692 373384008166 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 373384008167 active site 373384008168 Int/Topo IB signature motif; other site 373384008169 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 373384008170 SmpB-tmRNA interface; other site 373384008171 hypothetical protein; Validated; Region: PRK01777 373384008172 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 373384008173 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 373384008174 recombination and repair protein; Provisional; Region: PRK10869 373384008175 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 373384008176 Walker A/P-loop; other site 373384008177 ATP binding site [chemical binding]; other site 373384008178 Q-loop/lid; other site 373384008179 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 373384008180 Q-loop/lid; other site 373384008181 ABC transporter signature motif; other site 373384008182 Walker B; other site 373384008183 D-loop; other site 373384008184 H-loop/switch region; other site 373384008185 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 373384008186 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 373384008187 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 373384008188 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 373384008189 dimer interface [polypeptide binding]; other site 373384008190 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 373384008191 hypothetical protein; Provisional; Region: PRK11573 373384008192 Domain of unknown function DUF21; Region: DUF21; pfam01595 373384008193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373384008194 Transporter associated domain; Region: CorC_HlyC; smart01091 373384008195 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 373384008196 signal recognition particle protein; Provisional; Region: PRK10867 373384008197 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 373384008198 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 373384008199 P loop; other site 373384008200 GTP binding site [chemical binding]; other site 373384008201 Signal peptide binding domain; Region: SRP_SPB; pfam02978 373384008202 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 373384008203 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 373384008204 RimM N-terminal domain; Region: RimM; pfam01782 373384008205 PRC-barrel domain; Region: PRC; pfam05239 373384008206 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 373384008207 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 373384008208 putative outer membrane lipoprotein; Provisional; Region: PRK09967 373384008209 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373384008210 ligand binding site [chemical binding]; other site 373384008211 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 373384008212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384008213 metal binding site [ion binding]; metal-binding site 373384008214 active site 373384008215 I-site; other site 373384008216 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 373384008217 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 373384008218 lipoprotein; Provisional; Region: PRK11443 373384008219 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 373384008220 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 373384008221 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 373384008222 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 373384008223 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 373384008224 prephenate dehydrogenase; Validated; Region: PRK08507 373384008225 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 373384008226 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 373384008227 Prephenate dehydratase; Region: PDT; pfam00800 373384008228 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 373384008229 putative L-Phe binding site [chemical binding]; other site 373384008230 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 373384008231 30S subunit binding site; other site 373384008232 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384008233 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384008234 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384008235 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 373384008236 serine transporter; Region: stp; TIGR00814 373384008237 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 373384008238 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 373384008239 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 373384008240 flap endonuclease-like protein; Provisional; Region: PRK09482 373384008241 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 373384008242 active site 373384008243 metal binding site 1 [ion binding]; metal-binding site 373384008244 putative 5' ssDNA interaction site; other site 373384008245 metal binding site 3; metal-binding site 373384008246 metal binding site 2 [ion binding]; metal-binding site 373384008247 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 373384008248 putative DNA binding site [nucleotide binding]; other site 373384008249 putative metal binding site [ion binding]; other site 373384008250 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 373384008251 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 373384008252 dimer interface [polypeptide binding]; other site 373384008253 active site 373384008254 metal binding site [ion binding]; metal-binding site 373384008255 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 373384008256 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 373384008257 intersubunit interface [polypeptide binding]; other site 373384008258 active site 373384008259 Zn2+ binding site [ion binding]; other site 373384008260 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 373384008261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008262 putative substrate translocation pore; other site 373384008263 L-fucose isomerase; Provisional; Region: fucI; PRK10991 373384008264 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 373384008265 hexamer (dimer of trimers) interface [polypeptide binding]; other site 373384008266 trimer interface [polypeptide binding]; other site 373384008267 substrate binding site [chemical binding]; other site 373384008268 Mn binding site [ion binding]; other site 373384008269 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 373384008270 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 373384008271 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 373384008272 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384008273 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 373384008274 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 373384008275 hypothetical protein; Provisional; Region: PRK10873 373384008276 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 373384008277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384008278 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 373384008279 dimerization interface [polypeptide binding]; other site 373384008280 substrate binding pocket [chemical binding]; other site 373384008281 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 373384008282 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 373384008283 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 373384008284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373384008285 catalytic residue [active] 373384008286 CsdA-binding activator; Provisional; Region: PRK15019 373384008287 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 373384008288 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 373384008289 putative ATP binding site [chemical binding]; other site 373384008290 putative substrate interface [chemical binding]; other site 373384008291 murein transglycosylase A; Provisional; Region: mltA; PRK11162 373384008292 MltA specific insert domain; Region: MltA; pfam03562 373384008293 3D domain; Region: 3D; pfam06725 373384008294 AMIN domain; Region: AMIN; pfam11741 373384008295 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373384008296 active site 373384008297 metal binding site [ion binding]; metal-binding site 373384008298 N-acetylglutamate synthase; Validated; Region: PRK05279 373384008299 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 373384008300 putative feedback inhibition sensing region; other site 373384008301 putative nucleotide binding site [chemical binding]; other site 373384008302 putative substrate binding site [chemical binding]; other site 373384008303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384008304 Coenzyme A binding pocket [chemical binding]; other site 373384008305 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 373384008306 AAA domain; Region: AAA_30; pfam13604 373384008307 Family description; Region: UvrD_C_2; pfam13538 373384008308 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 373384008309 protease3; Provisional; Region: PRK15101 373384008310 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 373384008311 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373384008312 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373384008313 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 373384008314 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 373384008315 hypothetical protein; Provisional; Region: PRK10332 373384008316 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 373384008317 hypothetical protein; Provisional; Region: PRK11521 373384008318 hypothetical protein; Provisional; Region: PRK10557 373384008319 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 373384008320 thymidylate synthase; Reviewed; Region: thyA; PRK01827 373384008321 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 373384008322 dimerization interface [polypeptide binding]; other site 373384008323 active site 373384008324 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 373384008325 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 373384008326 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 373384008327 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 373384008328 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 373384008329 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 373384008330 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 373384008331 putative active site [active] 373384008332 Ap4A binding site [chemical binding]; other site 373384008333 nudix motif; other site 373384008334 putative metal binding site [ion binding]; other site 373384008335 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 373384008336 putative DNA-binding cleft [nucleotide binding]; other site 373384008337 putative DNA clevage site; other site 373384008338 molecular lever; other site 373384008339 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 373384008340 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 373384008341 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384008342 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384008343 active site 373384008344 catalytic tetrad [active] 373384008345 lysophospholipid transporter LplT; Provisional; Region: PRK11195 373384008346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008347 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 373384008348 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 373384008349 putative acyl-acceptor binding pocket; other site 373384008350 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 373384008351 acyl-activating enzyme (AAE) consensus motif; other site 373384008352 putative AMP binding site [chemical binding]; other site 373384008353 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 373384008354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384008355 DNA binding site [nucleotide binding] 373384008356 domain linker motif; other site 373384008357 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 373384008358 dimerization interface (closed form) [polypeptide binding]; other site 373384008359 ligand binding site [chemical binding]; other site 373384008360 diaminopimelate decarboxylase; Provisional; Region: PRK11165 373384008361 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 373384008362 active site 373384008363 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373384008364 substrate binding site [chemical binding]; other site 373384008365 catalytic residues [active] 373384008366 dimer interface [polypeptide binding]; other site 373384008367 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 373384008368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384008369 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 373384008370 putative dimerization interface [polypeptide binding]; other site 373384008371 putative racemase; Provisional; Region: PRK10200 373384008372 aspartate racemase; Region: asp_race; TIGR00035 373384008373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384008374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008375 putative substrate translocation pore; other site 373384008376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008377 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 373384008378 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 373384008379 NADP binding site [chemical binding]; other site 373384008380 homodimer interface [polypeptide binding]; other site 373384008381 active site 373384008382 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 373384008383 putative acyltransferase; Provisional; Region: PRK05790 373384008384 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 373384008385 dimer interface [polypeptide binding]; other site 373384008386 active site 373384008387 Transposase; Region: HTH_Tnp_1; cl17663 373384008388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384008389 putative transposase OrfB; Reviewed; Region: PHA02517 373384008390 HTH-like domain; Region: HTH_21; pfam13276 373384008391 Integrase core domain; Region: rve; pfam00665 373384008392 Integrase core domain; Region: rve_2; pfam13333 373384008393 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 373384008394 Peptidase family M23; Region: Peptidase_M23; pfam01551 373384008395 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008396 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 373384008397 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 373384008398 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 373384008399 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 373384008400 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 373384008401 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 373384008402 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 373384008403 catalytic loop [active] 373384008404 iron binding site [ion binding]; other site 373384008405 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 373384008406 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008407 xanthine permease; Region: pbuX; TIGR03173 373384008408 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 373384008409 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 373384008410 active site 373384008411 metal binding site [ion binding]; metal-binding site 373384008412 nudix motif; other site 373384008413 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 373384008414 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 373384008415 dimer interface [polypeptide binding]; other site 373384008416 putative anticodon binding site; other site 373384008417 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 373384008418 motif 1; other site 373384008419 active site 373384008420 motif 2; other site 373384008421 motif 3; other site 373384008422 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 373384008423 DHH family; Region: DHH; pfam01368 373384008424 DHHA1 domain; Region: DHHA1; pfam02272 373384008425 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 373384008426 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 373384008427 dimerization domain [polypeptide binding]; other site 373384008428 dimer interface [polypeptide binding]; other site 373384008429 catalytic residues [active] 373384008430 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 373384008431 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 373384008432 active site 373384008433 Int/Topo IB signature motif; other site 373384008434 flavodoxin FldB; Provisional; Region: PRK12359 373384008435 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 373384008436 hypothetical protein; Provisional; Region: PRK10878 373384008437 putative global regulator; Reviewed; Region: PRK09559 373384008438 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 373384008439 hemolysin; Provisional; Region: PRK15087 373384008440 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 373384008441 hypothetical protein; Provisional; Region: PRK04980 373384008442 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 373384008443 beta-galactosidase; Region: BGL; TIGR03356 373384008444 glycine dehydrogenase; Provisional; Region: PRK05367 373384008445 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 373384008446 tetramer interface [polypeptide binding]; other site 373384008447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384008448 catalytic residue [active] 373384008449 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 373384008450 tetramer interface [polypeptide binding]; other site 373384008451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384008452 catalytic residue [active] 373384008453 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 373384008454 lipoyl attachment site [posttranslational modification]; other site 373384008455 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 373384008456 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 373384008457 oxidoreductase; Provisional; Region: PRK08013 373384008458 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 373384008459 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 373384008460 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 373384008461 proline aminopeptidase P II; Provisional; Region: PRK10879 373384008462 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 373384008463 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 373384008464 active site 373384008465 hypothetical protein; Reviewed; Region: PRK01736 373384008466 Z-ring-associated protein; Provisional; Region: PRK10972 373384008467 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 373384008468 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 373384008469 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 373384008470 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 373384008471 ligand binding site [chemical binding]; other site 373384008472 NAD binding site [chemical binding]; other site 373384008473 tetramer interface [polypeptide binding]; other site 373384008474 catalytic site [active] 373384008475 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 373384008476 L-serine binding site [chemical binding]; other site 373384008477 ACT domain interface; other site 373384008478 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 373384008479 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373384008480 active site 373384008481 dimer interface [polypeptide binding]; other site 373384008482 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 373384008483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384008484 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 373384008485 putative dimerization interface [polypeptide binding]; other site 373384008486 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 373384008487 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 373384008488 active site 373384008489 substrate binding site [chemical binding]; other site 373384008490 coenzyme B12 binding site [chemical binding]; other site 373384008491 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 373384008492 B12 binding site [chemical binding]; other site 373384008493 cobalt ligand [ion binding]; other site 373384008494 membrane ATPase/protein kinase; Provisional; Region: PRK09435 373384008495 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 373384008496 Walker A; other site 373384008497 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 373384008498 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 373384008499 substrate binding site [chemical binding]; other site 373384008500 oxyanion hole (OAH) forming residues; other site 373384008501 trimer interface [polypeptide binding]; other site 373384008502 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 373384008503 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 373384008504 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 373384008505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384008506 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373384008507 oxidative stress defense protein; Provisional; Region: PRK11087 373384008508 Uncharacterized conserved protein [Function unknown]; Region: COG2968 373384008509 arginine exporter protein; Provisional; Region: PRK09304 373384008510 mechanosensitive channel MscS; Provisional; Region: PRK10334 373384008511 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373384008512 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 373384008513 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 373384008514 active site 373384008515 intersubunit interface [polypeptide binding]; other site 373384008516 zinc binding site [ion binding]; other site 373384008517 Na+ binding site [ion binding]; other site 373384008518 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 373384008519 Phosphoglycerate kinase; Region: PGK; pfam00162 373384008520 substrate binding site [chemical binding]; other site 373384008521 hinge regions; other site 373384008522 ADP binding site [chemical binding]; other site 373384008523 catalytic site [active] 373384008524 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 373384008525 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 373384008526 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 373384008527 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 373384008528 trimer interface [polypeptide binding]; other site 373384008529 putative Zn binding site [ion binding]; other site 373384008530 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 373384008531 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 373384008532 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 373384008533 Walker A/P-loop; other site 373384008534 ATP binding site [chemical binding]; other site 373384008535 Q-loop/lid; other site 373384008536 ABC transporter signature motif; other site 373384008537 Walker B; other site 373384008538 D-loop; other site 373384008539 H-loop/switch region; other site 373384008540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384008541 Q-loop/lid; other site 373384008542 ABC transporter signature motif; other site 373384008543 Walker B; other site 373384008544 D-loop; other site 373384008545 H-loop/switch region; other site 373384008546 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 373384008547 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 373384008548 active site 373384008549 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 373384008550 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 373384008551 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 373384008552 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 373384008553 putative active site [active] 373384008554 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 373384008555 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373384008556 putative NAD(P) binding site [chemical binding]; other site 373384008557 catalytic Zn binding site [ion binding]; other site 373384008558 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008559 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 373384008560 SPFH domain / Band 7 family; Region: Band_7; pfam01145 373384008561 transketolase; Reviewed; Region: PRK12753 373384008562 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 373384008563 TPP-binding site [chemical binding]; other site 373384008564 dimer interface [polypeptide binding]; other site 373384008565 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 373384008566 PYR/PP interface [polypeptide binding]; other site 373384008567 dimer interface [polypeptide binding]; other site 373384008568 TPP binding site [chemical binding]; other site 373384008569 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 373384008570 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 373384008571 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 373384008572 agmatinase; Region: agmatinase; TIGR01230 373384008573 oligomer interface [polypeptide binding]; other site 373384008574 putative active site [active] 373384008575 Mn binding site [ion binding]; other site 373384008576 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008577 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 373384008578 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 373384008579 dimer interface [polypeptide binding]; other site 373384008580 active site 373384008581 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373384008582 catalytic residues [active] 373384008583 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 373384008584 Virulence promoting factor; Region: YqgB; pfam11036 373384008585 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 373384008586 S-adenosylmethionine synthetase; Validated; Region: PRK05250 373384008587 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 373384008588 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 373384008589 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 373384008590 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 373384008591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008592 putative substrate translocation pore; other site 373384008593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008594 hypothetical protein; Provisional; Region: PRK04860 373384008595 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 373384008596 DNA-specific endonuclease I; Provisional; Region: PRK15137 373384008597 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 373384008598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 373384008599 RNA methyltransferase, RsmE family; Region: TIGR00046 373384008600 glutathione synthetase; Provisional; Region: PRK05246 373384008601 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 373384008602 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 373384008603 hypothetical protein; Validated; Region: PRK00228 373384008604 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 373384008605 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 373384008606 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 373384008607 Walker A motif; other site 373384008608 ATP binding site [chemical binding]; other site 373384008609 Walker B motif; other site 373384008610 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 373384008611 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373384008612 catalytic residue [active] 373384008613 YGGT family; Region: YGGT; pfam02325 373384008614 YGGT family; Region: YGGT; pfam02325 373384008615 hypothetical protein; Validated; Region: PRK05090 373384008616 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 373384008617 active site 373384008618 dimerization interface [polypeptide binding]; other site 373384008619 HemN family oxidoreductase; Provisional; Region: PRK05660 373384008620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384008621 FeS/SAM binding site; other site 373384008622 HemN C-terminal domain; Region: HemN_C; pfam06969 373384008623 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 373384008624 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 373384008625 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 373384008626 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 373384008627 DctM-like transporters; Region: DctM; pfam06808 373384008628 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 373384008629 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 373384008630 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 373384008631 homodimer interface [polypeptide binding]; other site 373384008632 active site 373384008633 hypothetical protein; Provisional; Region: PRK10626 373384008634 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 373384008635 hypothetical protein; Provisional; Region: PRK11702 373384008636 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 373384008637 adenine DNA glycosylase; Provisional; Region: PRK10880 373384008638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 373384008639 minor groove reading motif; other site 373384008640 helix-hairpin-helix signature motif; other site 373384008641 substrate binding pocket [chemical binding]; other site 373384008642 active site 373384008643 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 373384008644 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 373384008645 DNA binding and oxoG recognition site [nucleotide binding] 373384008646 oxidative damage protection protein; Provisional; Region: PRK05408 373384008647 murein transglycosylase C; Provisional; Region: mltC; PRK11671 373384008648 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 373384008649 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373384008650 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373384008651 catalytic residue [active] 373384008652 nucleoside transporter; Region: 2A0110; TIGR00889 373384008653 ornithine decarboxylase; Provisional; Region: PRK13578 373384008654 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 373384008655 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 373384008656 homodimer interface [polypeptide binding]; other site 373384008657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384008658 catalytic residue [active] 373384008659 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 373384008660 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 373384008661 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008662 glycolate transporter; Provisional; Region: PRK09695 373384008663 L-lactate permease; Region: Lactate_perm; cl00701 373384008664 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 373384008665 active site 373384008666 hypothetical protein; Provisional; Region: PRK09732 373384008667 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 373384008668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384008669 DNA-binding site [nucleotide binding]; DNA binding site 373384008670 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 373384008671 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008672 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 373384008673 CHAP domain; Region: CHAP; pfam05257 373384008674 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 373384008675 putative S-transferase; Provisional; Region: PRK11752 373384008676 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 373384008677 C-terminal domain interface [polypeptide binding]; other site 373384008678 GSH binding site (G-site) [chemical binding]; other site 373384008679 dimer interface [polypeptide binding]; other site 373384008680 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 373384008681 dimer interface [polypeptide binding]; other site 373384008682 N-terminal domain interface [polypeptide binding]; other site 373384008683 active site 373384008684 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 373384008685 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 373384008686 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 373384008687 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 373384008688 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 373384008689 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 373384008690 putative substrate-binding site; other site 373384008691 nickel binding site [ion binding]; other site 373384008692 hydrogenase 2 large subunit; Provisional; Region: PRK10467 373384008693 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 373384008694 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 373384008695 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 373384008696 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 373384008697 4Fe-4S binding domain; Region: Fer4_6; pfam12837 373384008698 hydrogenase 2 small subunit; Provisional; Region: PRK10468 373384008699 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 373384008700 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 373384008701 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 373384008702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373384008703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384008704 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384008705 active site 373384008706 catalytic tetrad [active] 373384008707 hypothetical protein; Provisional; Region: PRK05208 373384008708 oxidoreductase; Provisional; Region: PRK07985 373384008709 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 373384008710 NAD binding site [chemical binding]; other site 373384008711 metal binding site [ion binding]; metal-binding site 373384008712 active site 373384008713 biopolymer transport protein ExbD; Provisional; Region: PRK11267 373384008714 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 373384008715 biopolymer transport protein ExbB; Provisional; Region: PRK10414 373384008716 cystathionine beta-lyase; Provisional; Region: PRK08114 373384008717 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 373384008718 homodimer interface [polypeptide binding]; other site 373384008719 substrate-cofactor binding pocket; other site 373384008720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384008721 catalytic residue [active] 373384008722 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 373384008723 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 373384008724 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 373384008725 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 373384008726 dimer interface [polypeptide binding]; other site 373384008727 active site 373384008728 metal binding site [ion binding]; metal-binding site 373384008729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 373384008730 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 373384008731 active site 373384008732 catalytic tetrad [active] 373384008733 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 373384008734 putative outer membrane lipoprotein; Provisional; Region: PRK09973 373384008735 FtsI repressor; Provisional; Region: PRK10883 373384008736 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 373384008737 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 373384008738 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 373384008739 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 373384008740 putative acyl-acceptor binding pocket; other site 373384008741 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 373384008742 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 373384008743 CAP-like domain; other site 373384008744 active site 373384008745 primary dimer interface [polypeptide binding]; other site 373384008746 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 373384008747 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 373384008748 TIGR00156 family protein; Region: TIGR00156 373384008749 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 373384008750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384008751 active site 373384008752 phosphorylation site [posttranslational modification] 373384008753 intermolecular recognition site; other site 373384008754 dimerization interface [polypeptide binding]; other site 373384008755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384008756 DNA binding site [nucleotide binding] 373384008757 sensor protein QseC; Provisional; Region: PRK10337 373384008758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384008759 dimer interface [polypeptide binding]; other site 373384008760 phosphorylation site [posttranslational modification] 373384008761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384008762 ATP binding site [chemical binding]; other site 373384008763 Mg2+ binding site [ion binding]; other site 373384008764 G-X-G motif; other site 373384008765 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 373384008766 Uncharacterized conserved protein [Function unknown]; Region: COG1359 373384008767 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 373384008768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384008769 ATP binding site [chemical binding]; other site 373384008770 Mg2+ binding site [ion binding]; other site 373384008771 G-X-G motif; other site 373384008772 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 373384008773 anchoring element; other site 373384008774 dimer interface [polypeptide binding]; other site 373384008775 ATP binding site [chemical binding]; other site 373384008776 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 373384008777 active site 373384008778 metal binding site [ion binding]; metal-binding site 373384008779 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 373384008780 esterase YqiA; Provisional; Region: PRK11071 373384008781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 373384008782 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 373384008783 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 373384008784 active site 373384008785 metal binding site [ion binding]; metal-binding site 373384008786 hexamer interface [polypeptide binding]; other site 373384008787 putative dehydrogenase; Provisional; Region: PRK11039 373384008788 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 373384008789 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 373384008790 dimer interface [polypeptide binding]; other site 373384008791 ADP-ribose binding site [chemical binding]; other site 373384008792 active site 373384008793 nudix motif; other site 373384008794 metal binding site [ion binding]; metal-binding site 373384008795 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 373384008796 hypothetical protein; Provisional; Region: PRK11653 373384008797 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 373384008798 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 373384008799 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 373384008800 putative active site [active] 373384008801 metal binding site [ion binding]; metal-binding site 373384008802 zinc transporter ZupT; Provisional; Region: PRK04201 373384008803 ZIP Zinc transporter; Region: Zip; pfam02535 373384008804 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 373384008805 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 373384008806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 373384008807 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384008808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384008809 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384008810 HTH-like domain; Region: HTH_21; pfam13276 373384008811 Integrase core domain; Region: rve; pfam00665 373384008812 Integrase core domain; Region: rve_3; pfam13683 373384008813 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008814 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 373384008815 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 373384008816 putative ribose interaction site [chemical binding]; other site 373384008817 putative ADP binding site [chemical binding]; other site 373384008818 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 373384008819 active site 373384008820 nucleotide binding site [chemical binding]; other site 373384008821 HIGH motif; other site 373384008822 KMSKS motif; other site 373384008823 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 373384008824 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 373384008825 metal binding triad; other site 373384008826 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 373384008827 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 373384008828 metal binding triad; other site 373384008829 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 373384008830 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 373384008831 Uncharacterized conserved protein [Function unknown]; Region: COG3025 373384008832 putative active site [active] 373384008833 putative triphosphate binding site [ion binding]; other site 373384008834 putative metal binding residues [ion binding]; other site 373384008835 CHAD domain; Region: CHAD; pfam05235 373384008836 SH3 domain-containing protein; Provisional; Region: PRK10884 373384008837 Bacterial SH3 domain homologues; Region: SH3b; smart00287 373384008838 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 373384008839 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 373384008840 active site 373384008841 NTP binding site [chemical binding]; other site 373384008842 metal binding triad [ion binding]; metal-binding site 373384008843 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 373384008844 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373384008845 Zn2+ binding site [ion binding]; other site 373384008846 Mg2+ binding site [ion binding]; other site 373384008847 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 373384008848 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 373384008849 homooctamer interface [polypeptide binding]; other site 373384008850 active site 373384008851 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 373384008852 transcriptional activator TtdR; Provisional; Region: PRK09801 373384008853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384008854 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 373384008855 putative effector binding pocket; other site 373384008856 putative dimerization interface [polypeptide binding]; other site 373384008857 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 373384008858 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 373384008859 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 373384008860 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 373384008861 transmembrane helices; other site 373384008862 UGMP family protein; Validated; Region: PRK09604 373384008863 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 373384008864 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 373384008865 DNA primase; Validated; Region: dnaG; PRK05667 373384008866 CHC2 zinc finger; Region: zf-CHC2; pfam01807 373384008867 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 373384008868 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 373384008869 active site 373384008870 metal binding site [ion binding]; metal-binding site 373384008871 interdomain interaction site; other site 373384008872 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 373384008873 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 373384008874 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 373384008875 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 373384008876 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 373384008877 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 373384008878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373384008879 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 373384008880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373384008881 DNA binding residues [nucleotide binding] 373384008882 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384008883 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384008884 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384008885 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 373384008886 active site 373384008887 SUMO-1 interface [polypeptide binding]; other site 373384008888 Predicted transcriptional regulators [Transcription]; Region: COG1695 373384008889 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 373384008890 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 373384008891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373384008892 inhibitor-cofactor binding pocket; inhibition site 373384008893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384008894 catalytic residue [active] 373384008895 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 373384008896 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384008897 DNA binding site [nucleotide binding] 373384008898 domain linker motif; other site 373384008899 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 373384008900 putative dimerization interface [polypeptide binding]; other site 373384008901 putative ligand binding site [chemical binding]; other site 373384008902 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 373384008903 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 373384008904 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 373384008905 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 373384008906 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 373384008907 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 373384008908 inner membrane transporter YjeM; Provisional; Region: PRK15238 373384008909 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 373384008910 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 373384008911 active site 373384008912 FMN binding site [chemical binding]; other site 373384008913 2,4-decadienoyl-CoA binding site; other site 373384008914 catalytic residue [active] 373384008915 4Fe-4S cluster binding site [ion binding]; other site 373384008916 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 373384008917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384008918 non-specific DNA binding site [nucleotide binding]; other site 373384008919 salt bridge; other site 373384008920 sequence-specific DNA binding site [nucleotide binding]; other site 373384008921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 373384008922 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 373384008923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384008924 S-adenosylmethionine binding site [chemical binding]; other site 373384008925 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 373384008926 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 373384008927 putative active site [active] 373384008928 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 373384008929 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373384008930 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 373384008931 serine/threonine transporter SstT; Provisional; Region: PRK13628 373384008932 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 373384008933 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 373384008934 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 373384008935 galactarate dehydratase; Region: galactar-dH20; TIGR03248 373384008936 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 373384008937 Glucuronate isomerase; Region: UxaC; pfam02614 373384008938 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 373384008939 D-galactonate transporter; Region: 2A0114; TIGR00893 373384008940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384008941 putative substrate translocation pore; other site 373384008942 CblD like pilus biogenesis initiator; Region: CblD; cl06460 373384008943 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 373384008944 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384008945 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384008946 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 373384008947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384008948 DNA-binding site [nucleotide binding]; DNA binding site 373384008949 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 373384008950 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 373384008951 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 373384008952 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 373384008953 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 373384008954 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 373384008955 Predicted membrane protein [Function unknown]; Region: COG5393 373384008956 YqjK-like protein; Region: YqjK; pfam13997 373384008957 Predicted membrane protein [Function unknown]; Region: COG2259 373384008958 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 373384008959 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 373384008960 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 373384008961 putative dimer interface [polypeptide binding]; other site 373384008962 N-terminal domain interface [polypeptide binding]; other site 373384008963 putative substrate binding pocket (H-site) [chemical binding]; other site 373384008964 Predicted membrane protein [Function unknown]; Region: COG3152 373384008965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384008966 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 373384008967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384008968 dimerization interface [polypeptide binding]; other site 373384008969 Pirin-related protein [General function prediction only]; Region: COG1741 373384008970 Pirin; Region: Pirin; pfam02678 373384008971 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 373384008972 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 373384008973 serine transporter; Region: stp; TIGR00814 373384008974 L-serine dehydratase TdcG; Provisional; Region: PRK15040 373384008975 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 373384008976 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 373384008977 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 373384008978 homotrimer interaction site [polypeptide binding]; other site 373384008979 putative active site [active] 373384008980 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 373384008981 Pyruvate formate lyase 1; Region: PFL1; cd01678 373384008982 coenzyme A binding site [chemical binding]; other site 373384008983 active site 373384008984 catalytic residues [active] 373384008985 glycine loop; other site 373384008986 propionate/acetate kinase; Provisional; Region: PRK12379 373384008987 Acetokinase family; Region: Acetate_kinase; cl17229 373384008988 threonine/serine transporter TdcC; Provisional; Region: PRK13629 373384008989 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 373384008990 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 373384008991 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 373384008992 tetramer interface [polypeptide binding]; other site 373384008993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384008994 catalytic residue [active] 373384008995 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 373384008996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384008997 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 373384008998 putative substrate binding pocket [chemical binding]; other site 373384008999 putative dimerization interface [polypeptide binding]; other site 373384009000 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 373384009001 hypothetical protein; Provisional; Region: PRK09716 373384009002 glycerate kinase I; Provisional; Region: PRK10342 373384009003 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 373384009004 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 373384009005 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 373384009006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384009007 D-galactonate transporter; Region: 2A0114; TIGR00893 373384009008 putative substrate translocation pore; other site 373384009009 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384009010 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 373384009011 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384009012 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384009013 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384009014 HTH-like domain; Region: HTH_21; pfam13276 373384009015 Integrase core domain; Region: rve; pfam00665 373384009016 Integrase core domain; Region: rve_3; pfam13683 373384009017 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384009018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384009019 Fimbrial protein; Region: Fimbrial; pfam00419 373384009020 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 373384009021 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 373384009022 putative SAM binding site [chemical binding]; other site 373384009023 putative homodimer interface [polypeptide binding]; other site 373384009024 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 373384009025 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 373384009026 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 373384009027 putative ligand binding site [chemical binding]; other site 373384009028 TIGR00252 family protein; Region: TIGR00252 373384009029 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 373384009030 dimer interface [polypeptide binding]; other site 373384009031 active site 373384009032 outer membrane lipoprotein; Provisional; Region: PRK11023 373384009033 BON domain; Region: BON; pfam04972 373384009034 BON domain; Region: BON; pfam04972 373384009035 Predicted permease; Region: DUF318; pfam03773 373384009036 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 373384009037 NADH(P)-binding; Region: NAD_binding_10; pfam13460 373384009038 NAD binding site [chemical binding]; other site 373384009039 active site 373384009040 intracellular protease, PfpI family; Region: PfpI; TIGR01382 373384009041 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 373384009042 proposed catalytic triad [active] 373384009043 conserved cys residue [active] 373384009044 hypothetical protein; Provisional; Region: PRK03467 373384009045 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 373384009046 GIY-YIG motif/motif A; other site 373384009047 putative active site [active] 373384009048 putative metal binding site [ion binding]; other site 373384009049 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 373384009050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384009051 Coenzyme A binding pocket [chemical binding]; other site 373384009052 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 373384009053 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 373384009054 Peptidase family U32; Region: Peptidase_U32; pfam01136 373384009055 putative protease; Provisional; Region: PRK15447 373384009056 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 373384009057 hypothetical protein; Provisional; Region: PRK10508 373384009058 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 373384009059 tryptophan permease; Provisional; Region: PRK10483 373384009060 aromatic amino acid transport protein; Region: araaP; TIGR00837 373384009061 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 373384009062 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 373384009063 ATP binding site [chemical binding]; other site 373384009064 Mg++ binding site [ion binding]; other site 373384009065 motif III; other site 373384009066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384009067 nucleotide binding region [chemical binding]; other site 373384009068 ATP-binding site [chemical binding]; other site 373384009069 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 373384009070 putative RNA binding site [nucleotide binding]; other site 373384009071 lipoprotein NlpI; Provisional; Region: PRK11189 373384009072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373384009073 binding surface 373384009074 TPR motif; other site 373384009075 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 373384009076 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 373384009077 RNase E interface [polypeptide binding]; other site 373384009078 trimer interface [polypeptide binding]; other site 373384009079 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 373384009080 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 373384009081 RNase E interface [polypeptide binding]; other site 373384009082 trimer interface [polypeptide binding]; other site 373384009083 active site 373384009084 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 373384009085 putative nucleic acid binding region [nucleotide binding]; other site 373384009086 G-X-X-G motif; other site 373384009087 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 373384009088 RNA binding site [nucleotide binding]; other site 373384009089 domain interface; other site 373384009090 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 373384009091 16S/18S rRNA binding site [nucleotide binding]; other site 373384009092 S13e-L30e interaction site [polypeptide binding]; other site 373384009093 25S rRNA binding site [nucleotide binding]; other site 373384009094 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 373384009095 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 373384009096 RNA binding site [nucleotide binding]; other site 373384009097 active site 373384009098 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 373384009099 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 373384009100 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 373384009101 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 373384009102 translation initiation factor IF-2; Region: IF-2; TIGR00487 373384009103 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 373384009104 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 373384009105 G1 box; other site 373384009106 putative GEF interaction site [polypeptide binding]; other site 373384009107 GTP/Mg2+ binding site [chemical binding]; other site 373384009108 Switch I region; other site 373384009109 G2 box; other site 373384009110 G3 box; other site 373384009111 Switch II region; other site 373384009112 G4 box; other site 373384009113 G5 box; other site 373384009114 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 373384009115 Translation-initiation factor 2; Region: IF-2; pfam11987 373384009116 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 373384009117 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 373384009118 NusA N-terminal domain; Region: NusA_N; pfam08529 373384009119 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 373384009120 RNA binding site [nucleotide binding]; other site 373384009121 homodimer interface [polypeptide binding]; other site 373384009122 NusA-like KH domain; Region: KH_5; pfam13184 373384009123 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 373384009124 G-X-X-G motif; other site 373384009125 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 373384009126 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 373384009127 ribosome maturation protein RimP; Reviewed; Region: PRK00092 373384009128 Sm and related proteins; Region: Sm_like; cl00259 373384009129 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 373384009130 putative oligomer interface [polypeptide binding]; other site 373384009131 putative RNA binding site [nucleotide binding]; other site 373384009132 argininosuccinate synthase; Validated; Region: PRK05370 373384009133 Preprotein translocase SecG subunit; Region: SecG; pfam03840 373384009134 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 373384009135 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 373384009136 active site 373384009137 substrate binding site [chemical binding]; other site 373384009138 metal binding site [ion binding]; metal-binding site 373384009139 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 373384009140 dihydropteroate synthase; Region: DHPS; TIGR01496 373384009141 substrate binding pocket [chemical binding]; other site 373384009142 dimer interface [polypeptide binding]; other site 373384009143 inhibitor binding site; inhibition site 373384009144 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 373384009145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384009146 Walker A motif; other site 373384009147 ATP binding site [chemical binding]; other site 373384009148 Walker B motif; other site 373384009149 arginine finger; other site 373384009150 Peptidase family M41; Region: Peptidase_M41; pfam01434 373384009151 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 373384009152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384009153 S-adenosylmethionine binding site [chemical binding]; other site 373384009154 RNA-binding protein YhbY; Provisional; Region: PRK10343 373384009155 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 373384009156 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 373384009157 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 373384009158 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 373384009159 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 373384009160 GTPase CgtA; Reviewed; Region: obgE; PRK12298 373384009161 GTP1/OBG; Region: GTP1_OBG; pfam01018 373384009162 Obg GTPase; Region: Obg; cd01898 373384009163 G1 box; other site 373384009164 GTP/Mg2+ binding site [chemical binding]; other site 373384009165 Switch I region; other site 373384009166 G2 box; other site 373384009167 G3 box; other site 373384009168 Switch II region; other site 373384009169 G4 box; other site 373384009170 G5 box; other site 373384009171 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 373384009172 EamA-like transporter family; Region: EamA; pfam00892 373384009173 EamA-like transporter family; Region: EamA; pfam00892 373384009174 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 373384009175 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 373384009176 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 373384009177 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 373384009178 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 373384009179 substrate binding pocket [chemical binding]; other site 373384009180 chain length determination region; other site 373384009181 substrate-Mg2+ binding site; other site 373384009182 catalytic residues [active] 373384009183 aspartate-rich region 1; other site 373384009184 active site lid residues [active] 373384009185 aspartate-rich region 2; other site 373384009186 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 373384009187 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 373384009188 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 373384009189 hinge; other site 373384009190 active site 373384009191 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 373384009192 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 373384009193 anti sigma factor interaction site; other site 373384009194 regulatory phosphorylation site [posttranslational modification]; other site 373384009195 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 373384009196 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 373384009197 mce related protein; Region: MCE; pfam02470 373384009198 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 373384009199 conserved hypothetical integral membrane protein; Region: TIGR00056 373384009200 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 373384009201 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 373384009202 Walker A/P-loop; other site 373384009203 ATP binding site [chemical binding]; other site 373384009204 Q-loop/lid; other site 373384009205 ABC transporter signature motif; other site 373384009206 Walker B; other site 373384009207 D-loop; other site 373384009208 H-loop/switch region; other site 373384009209 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 373384009210 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373384009211 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 373384009212 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 373384009213 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 373384009214 putative active site [active] 373384009215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 373384009216 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 373384009217 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 373384009218 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 373384009219 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 373384009220 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 373384009221 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 373384009222 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 373384009223 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 373384009224 Walker A/P-loop; other site 373384009225 ATP binding site [chemical binding]; other site 373384009226 Q-loop/lid; other site 373384009227 ABC transporter signature motif; other site 373384009228 Walker B; other site 373384009229 D-loop; other site 373384009230 H-loop/switch region; other site 373384009231 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 373384009232 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 373384009233 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 373384009234 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 373384009235 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 373384009236 30S subunit binding site; other site 373384009237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 373384009238 active site 373384009239 phosphorylation site [posttranslational modification] 373384009240 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 373384009241 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 373384009242 dimerization domain swap beta strand [polypeptide binding]; other site 373384009243 regulatory protein interface [polypeptide binding]; other site 373384009244 active site 373384009245 regulatory phosphorylation site [posttranslational modification]; other site 373384009246 hypothetical protein; Provisional; Region: PRK10345 373384009247 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 373384009248 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 373384009249 conserved cys residue [active] 373384009250 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 373384009251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373384009252 putative active site [active] 373384009253 heme pocket [chemical binding]; other site 373384009254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384009255 dimer interface [polypeptide binding]; other site 373384009256 phosphorylation site [posttranslational modification] 373384009257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384009258 ATP binding site [chemical binding]; other site 373384009259 Mg2+ binding site [ion binding]; other site 373384009260 G-X-G motif; other site 373384009261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384009262 active site 373384009263 phosphorylation site [posttranslational modification] 373384009264 intermolecular recognition site; other site 373384009265 dimerization interface [polypeptide binding]; other site 373384009266 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 373384009267 putative binding surface; other site 373384009268 active site 373384009269 radical SAM protein, TIGR01212 family; Region: TIGR01212 373384009270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384009271 FeS/SAM binding site; other site 373384009272 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 373384009273 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 373384009274 active site 373384009275 dimer interface [polypeptide binding]; other site 373384009276 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 373384009277 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 373384009278 active site 373384009279 FMN binding site [chemical binding]; other site 373384009280 substrate binding site [chemical binding]; other site 373384009281 3Fe-4S cluster binding site [ion binding]; other site 373384009282 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 373384009283 domain interface; other site 373384009284 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 373384009285 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 373384009286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373384009287 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384009288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384009289 Transposase; Region: HTH_Tnp_1; pfam01527 373384009290 HTH-like domain; Region: HTH_21; pfam13276 373384009291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384009292 Integrase core domain; Region: rve; pfam00665 373384009293 Integrase core domain; Region: rve_3; pfam13683 373384009294 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 373384009295 N-acetylmannosamine kinase; Provisional; Region: PRK05082 373384009296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 373384009297 nucleotide binding site [chemical binding]; other site 373384009298 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 373384009299 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 373384009300 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 373384009301 putative active site cavity [active] 373384009302 putative sialic acid transporter; Provisional; Region: PRK03893 373384009303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384009304 putative substrate translocation pore; other site 373384009305 N-acetylneuraminate lyase; Region: nanA; TIGR00683 373384009306 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 373384009307 inhibitor site; inhibition site 373384009308 active site 373384009309 dimer interface [polypeptide binding]; other site 373384009310 catalytic residue [active] 373384009311 transcriptional regulator NanR; Provisional; Region: PRK03837 373384009312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384009313 DNA-binding site [nucleotide binding]; DNA binding site 373384009314 FCD domain; Region: FCD; pfam07729 373384009315 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384009316 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 373384009317 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 373384009318 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 373384009319 stringent starvation protein A; Provisional; Region: sspA; PRK09481 373384009320 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 373384009321 C-terminal domain interface [polypeptide binding]; other site 373384009322 putative GSH binding site (G-site) [chemical binding]; other site 373384009323 dimer interface [polypeptide binding]; other site 373384009324 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 373384009325 dimer interface [polypeptide binding]; other site 373384009326 N-terminal domain interface [polypeptide binding]; other site 373384009327 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 373384009328 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 373384009329 23S rRNA interface [nucleotide binding]; other site 373384009330 L3 interface [polypeptide binding]; other site 373384009331 Predicted ATPase [General function prediction only]; Region: COG1485 373384009332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 373384009333 hypothetical protein; Provisional; Region: PRK11677 373384009334 serine endoprotease; Provisional; Region: PRK10139 373384009335 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373384009336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373384009337 protein binding site [polypeptide binding]; other site 373384009338 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373384009339 serine endoprotease; Provisional; Region: PRK10898 373384009340 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 373384009341 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 373384009342 malate dehydrogenase; Provisional; Region: PRK05086 373384009343 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 373384009344 NAD binding site [chemical binding]; other site 373384009345 dimerization interface [polypeptide binding]; other site 373384009346 Substrate binding site [chemical binding]; other site 373384009347 arginine repressor; Provisional; Region: PRK05066 373384009348 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 373384009349 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 373384009350 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 373384009351 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 373384009352 RNAase interaction site [polypeptide binding]; other site 373384009353 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 373384009354 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 373384009355 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 373384009356 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384009357 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384009358 efflux system membrane protein; Provisional; Region: PRK11594 373384009359 transcriptional regulator; Provisional; Region: PRK10632 373384009360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384009361 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 373384009362 putative effector binding pocket; other site 373384009363 dimerization interface [polypeptide binding]; other site 373384009364 protease TldD; Provisional; Region: tldD; PRK10735 373384009365 hypothetical protein; Provisional; Region: PRK10899 373384009366 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 373384009367 ribonuclease G; Provisional; Region: PRK11712 373384009368 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 373384009369 homodimer interface [polypeptide binding]; other site 373384009370 oligonucleotide binding site [chemical binding]; other site 373384009371 Maf-like protein; Region: Maf; pfam02545 373384009372 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 373384009373 active site 373384009374 dimer interface [polypeptide binding]; other site 373384009375 rod shape-determining protein MreD; Provisional; Region: PRK11060 373384009376 rod shape-determining protein MreC; Region: mreC; TIGR00219 373384009377 rod shape-determining protein MreC; Region: MreC; pfam04085 373384009378 rod shape-determining protein MreB; Provisional; Region: PRK13927 373384009379 MreB and similar proteins; Region: MreB_like; cd10225 373384009380 nucleotide binding site [chemical binding]; other site 373384009381 Mg binding site [ion binding]; other site 373384009382 putative protofilament interaction site [polypeptide binding]; other site 373384009383 RodZ interaction site [polypeptide binding]; other site 373384009384 regulatory protein CsrD; Provisional; Region: PRK11059 373384009385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384009386 metal binding site [ion binding]; metal-binding site 373384009387 active site 373384009388 I-site; other site 373384009389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384009390 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 373384009391 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 373384009392 NADP binding site [chemical binding]; other site 373384009393 dimer interface [polypeptide binding]; other site 373384009394 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 373384009395 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 373384009396 carboxyltransferase (CT) interaction site; other site 373384009397 biotinylation site [posttranslational modification]; other site 373384009398 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 373384009399 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 373384009400 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 373384009401 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 373384009402 hypothetical protein; Provisional; Region: PRK10633 373384009403 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 373384009404 Na binding site [ion binding]; other site 373384009405 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 373384009406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 373384009407 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 373384009408 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 373384009409 FMN binding site [chemical binding]; other site 373384009410 active site 373384009411 catalytic residues [active] 373384009412 substrate binding site [chemical binding]; other site 373384009413 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 373384009414 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 373384009415 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 373384009416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384009417 DNA methylase; Region: N6_N4_Mtase; pfam01555 373384009418 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384009419 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 373384009420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384009421 substrate binding pocket [chemical binding]; other site 373384009422 membrane-bound complex binding site; other site 373384009423 hinge residues; other site 373384009424 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 373384009425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384009426 dimer interface [polypeptide binding]; other site 373384009427 conserved gate region; other site 373384009428 putative PBP binding loops; other site 373384009429 ABC-ATPase subunit interface; other site 373384009430 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 373384009431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 373384009432 Walker A/P-loop; other site 373384009433 ATP binding site [chemical binding]; other site 373384009434 Q-loop/lid; other site 373384009435 ABC transporter signature motif; other site 373384009436 Walker B; other site 373384009437 D-loop; other site 373384009438 H-loop/switch region; other site 373384009439 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 373384009440 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 373384009441 trimer interface [polypeptide binding]; other site 373384009442 putative metal binding site [ion binding]; other site 373384009443 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 373384009444 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 373384009445 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 373384009446 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 373384009447 shikimate binding site; other site 373384009448 NAD(P) binding site [chemical binding]; other site 373384009449 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 373384009450 hypothetical protein; Validated; Region: PRK03430 373384009451 hypothetical protein; Provisional; Region: PRK10736 373384009452 DNA protecting protein DprA; Region: dprA; TIGR00732 373384009453 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 373384009454 active site 373384009455 catalytic residues [active] 373384009456 metal binding site [ion binding]; metal-binding site 373384009457 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 373384009458 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 373384009459 putative active site [active] 373384009460 substrate binding site [chemical binding]; other site 373384009461 putative cosubstrate binding site; other site 373384009462 catalytic site [active] 373384009463 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 373384009464 substrate binding site [chemical binding]; other site 373384009465 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 373384009466 putative RNA binding site [nucleotide binding]; other site 373384009467 16S rRNA methyltransferase B; Provisional; Region: PRK10901 373384009468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384009469 S-adenosylmethionine binding site [chemical binding]; other site 373384009470 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 373384009471 TrkA-N domain; Region: TrkA_N; pfam02254 373384009472 TrkA-C domain; Region: TrkA_C; pfam02080 373384009473 TrkA-N domain; Region: TrkA_N; pfam02254 373384009474 TrkA-C domain; Region: TrkA_C; pfam02080 373384009475 Homeodomain-like domain; Region: HTH_23; pfam13384 373384009476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384009477 Transposase; Region: HTH_Tnp_1; pfam01527 373384009478 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384009479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384009480 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 373384009481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384009482 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 373384009483 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 373384009484 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 373384009485 Homeodomain-like domain; Region: HTH_23; pfam13384 373384009486 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 373384009487 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 373384009488 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 373384009489 alphaNTD homodimer interface [polypeptide binding]; other site 373384009490 alphaNTD - beta interaction site [polypeptide binding]; other site 373384009491 alphaNTD - beta' interaction site [polypeptide binding]; other site 373384009492 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 373384009493 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 373384009494 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 373384009495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384009496 RNA binding surface [nucleotide binding]; other site 373384009497 30S ribosomal protein S11; Validated; Region: PRK05309 373384009498 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 373384009499 30S ribosomal protein S13; Region: bact_S13; TIGR03631 373384009500 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 373384009501 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 373384009502 SecY translocase; Region: SecY; pfam00344 373384009503 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 373384009504 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 373384009505 23S rRNA binding site [nucleotide binding]; other site 373384009506 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 373384009507 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 373384009508 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 373384009509 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 373384009510 23S rRNA interface [nucleotide binding]; other site 373384009511 5S rRNA interface [nucleotide binding]; other site 373384009512 L27 interface [polypeptide binding]; other site 373384009513 L5 interface [polypeptide binding]; other site 373384009514 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 373384009515 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 373384009516 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 373384009517 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 373384009518 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 373384009519 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 373384009520 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 373384009521 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 373384009522 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 373384009523 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 373384009524 RNA binding site [nucleotide binding]; other site 373384009525 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 373384009526 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 373384009527 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 373384009528 23S rRNA interface [nucleotide binding]; other site 373384009529 putative translocon interaction site; other site 373384009530 signal recognition particle (SRP54) interaction site; other site 373384009531 L23 interface [polypeptide binding]; other site 373384009532 trigger factor interaction site; other site 373384009533 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 373384009534 23S rRNA interface [nucleotide binding]; other site 373384009535 5S rRNA interface [nucleotide binding]; other site 373384009536 putative antibiotic binding site [chemical binding]; other site 373384009537 L25 interface [polypeptide binding]; other site 373384009538 L27 interface [polypeptide binding]; other site 373384009539 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 373384009540 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 373384009541 G-X-X-G motif; other site 373384009542 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 373384009543 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 373384009544 protein-rRNA interface [nucleotide binding]; other site 373384009545 putative translocon binding site; other site 373384009546 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 373384009547 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 373384009548 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 373384009549 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 373384009550 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 373384009551 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 373384009552 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 373384009553 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 373384009554 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 373384009555 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 373384009556 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 373384009557 heme binding site [chemical binding]; other site 373384009558 ferroxidase pore; other site 373384009559 ferroxidase diiron center [ion binding]; other site 373384009560 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 373384009561 elongation factor Tu; Reviewed; Region: PRK00049 373384009562 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 373384009563 G1 box; other site 373384009564 GEF interaction site [polypeptide binding]; other site 373384009565 GTP/Mg2+ binding site [chemical binding]; other site 373384009566 Switch I region; other site 373384009567 G2 box; other site 373384009568 G3 box; other site 373384009569 Switch II region; other site 373384009570 G4 box; other site 373384009571 G5 box; other site 373384009572 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 373384009573 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 373384009574 Antibiotic Binding Site [chemical binding]; other site 373384009575 elongation factor G; Reviewed; Region: PRK00007 373384009576 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 373384009577 G1 box; other site 373384009578 putative GEF interaction site [polypeptide binding]; other site 373384009579 GTP/Mg2+ binding site [chemical binding]; other site 373384009580 Switch I region; other site 373384009581 G2 box; other site 373384009582 G3 box; other site 373384009583 Switch II region; other site 373384009584 G4 box; other site 373384009585 G5 box; other site 373384009586 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 373384009587 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 373384009588 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 373384009589 30S ribosomal protein S7; Validated; Region: PRK05302 373384009590 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 373384009591 S17 interaction site [polypeptide binding]; other site 373384009592 S8 interaction site; other site 373384009593 16S rRNA interaction site [nucleotide binding]; other site 373384009594 streptomycin interaction site [chemical binding]; other site 373384009595 23S rRNA interaction site [nucleotide binding]; other site 373384009596 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 373384009597 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 373384009598 sulfur relay protein TusC; Validated; Region: PRK00211 373384009599 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 373384009600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 373384009601 YheO-like PAS domain; Region: PAS_6; pfam08348 373384009602 HTH domain; Region: HTH_22; pfam13309 373384009603 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 373384009604 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 373384009605 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373384009606 phi X174 lysis protein; Provisional; Region: PRK02793 373384009607 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 373384009608 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373384009609 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 373384009610 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 373384009611 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 373384009612 TrkA-N domain; Region: TrkA_N; pfam02254 373384009613 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 373384009614 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 373384009615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384009616 Walker A/P-loop; other site 373384009617 ATP binding site [chemical binding]; other site 373384009618 Q-loop/lid; other site 373384009619 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373384009620 ABC transporter; Region: ABC_tran_2; pfam12848 373384009621 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373384009622 putative hydrolase; Provisional; Region: PRK10985 373384009623 hypothetical protein; Provisional; Region: PRK04966 373384009624 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 373384009625 active site 373384009626 hypothetical protein; Provisional; Region: PRK10738 373384009627 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 373384009628 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 373384009629 ligand binding site [chemical binding]; other site 373384009630 flexible hinge region; other site 373384009631 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 373384009632 putative switch regulator; other site 373384009633 non-specific DNA interactions [nucleotide binding]; other site 373384009634 DNA binding site [nucleotide binding] 373384009635 sequence specific DNA binding site [nucleotide binding]; other site 373384009636 putative cAMP binding site [chemical binding]; other site 373384009637 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 373384009638 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 373384009639 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 373384009640 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 373384009641 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 373384009642 inhibitor-cofactor binding pocket; inhibition site 373384009643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384009644 catalytic residue [active] 373384009645 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 373384009646 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 373384009647 glutamine binding [chemical binding]; other site 373384009648 catalytic triad [active] 373384009649 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 373384009650 cell filamentation protein Fic; Provisional; Region: PRK10347 373384009651 hypothetical protein; Provisional; Region: PRK10204 373384009652 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 373384009653 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 373384009654 substrate binding site [chemical binding]; other site 373384009655 putative transporter; Provisional; Region: PRK03699 373384009656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384009657 putative substrate translocation pore; other site 373384009658 nitrite reductase subunit NirD; Provisional; Region: PRK14989 373384009659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384009660 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 373384009661 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 373384009662 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 373384009663 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 373384009664 nitrite transporter NirC; Provisional; Region: PRK11562 373384009665 siroheme synthase; Provisional; Region: cysG; PRK10637 373384009666 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 373384009667 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 373384009668 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 373384009669 active site 373384009670 SAM binding site [chemical binding]; other site 373384009671 homodimer interface [polypeptide binding]; other site 373384009672 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 373384009673 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 373384009674 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 373384009675 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 373384009676 dimer interface [polypeptide binding]; other site 373384009677 active site 373384009678 fructoselysine 3-epimerase; Provisional; Region: PRK09856 373384009679 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 373384009680 AP (apurinic/apyrimidinic) site pocket; other site 373384009681 DNA interaction; other site 373384009682 Metal-binding active site; metal-binding site 373384009683 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 373384009684 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384009685 substrate binding site [chemical binding]; other site 373384009686 ATP binding site [chemical binding]; other site 373384009687 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 373384009688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384009689 DNA-binding site [nucleotide binding]; DNA binding site 373384009690 UTRA domain; Region: UTRA; pfam07702 373384009691 Protein of unknown function; Region: YhfT; pfam10797 373384009692 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 373384009693 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 373384009694 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 373384009695 active site 373384009696 substrate binding pocket [chemical binding]; other site 373384009697 homodimer interaction site [polypeptide binding]; other site 373384009698 putative mutase; Provisional; Region: PRK12383 373384009699 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 373384009700 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 373384009701 dimer interface [polypeptide binding]; other site 373384009702 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 373384009703 active site 373384009704 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373384009705 substrate binding site [chemical binding]; other site 373384009706 catalytic residue [active] 373384009707 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 373384009708 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 373384009709 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 373384009710 active site 373384009711 HIGH motif; other site 373384009712 dimer interface [polypeptide binding]; other site 373384009713 KMSKS motif; other site 373384009714 phosphoglycolate phosphatase; Provisional; Region: PRK13222 373384009715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384009716 motif II; other site 373384009717 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 373384009718 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 373384009719 substrate binding site [chemical binding]; other site 373384009720 hexamer interface [polypeptide binding]; other site 373384009721 metal binding site [ion binding]; metal-binding site 373384009722 DNA adenine methylase; Provisional; Region: PRK10904 373384009723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 373384009724 cell division protein DamX; Validated; Region: PRK10905 373384009725 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 373384009726 active site 373384009727 dimer interface [polypeptide binding]; other site 373384009728 metal binding site [ion binding]; metal-binding site 373384009729 shikimate kinase; Reviewed; Region: aroK; PRK00131 373384009730 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 373384009731 ADP binding site [chemical binding]; other site 373384009732 magnesium binding site [ion binding]; other site 373384009733 putative shikimate binding site; other site 373384009734 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 373384009735 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 373384009736 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 373384009737 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 373384009738 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 373384009739 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 373384009740 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 373384009741 Transglycosylase; Region: Transgly; pfam00912 373384009742 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 373384009743 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 373384009744 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 373384009745 ADP-ribose binding site [chemical binding]; other site 373384009746 dimer interface [polypeptide binding]; other site 373384009747 active site 373384009748 nudix motif; other site 373384009749 metal binding site [ion binding]; metal-binding site 373384009750 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 373384009751 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 373384009752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384009753 motif II; other site 373384009754 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384009755 RNA binding surface [nucleotide binding]; other site 373384009756 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 373384009757 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 373384009758 dimerization interface [polypeptide binding]; other site 373384009759 domain crossover interface; other site 373384009760 redox-dependent activation switch; other site 373384009761 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 373384009762 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 373384009763 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 373384009764 active site 373384009765 substrate-binding site [chemical binding]; other site 373384009766 metal-binding site [ion binding] 373384009767 ATP binding site [chemical binding]; other site 373384009768 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 373384009769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384009770 dimerization interface [polypeptide binding]; other site 373384009771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384009772 dimer interface [polypeptide binding]; other site 373384009773 phosphorylation site [posttranslational modification] 373384009774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384009775 ATP binding site [chemical binding]; other site 373384009776 G-X-G motif; other site 373384009777 osmolarity response regulator; Provisional; Region: ompR; PRK09468 373384009778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384009779 active site 373384009780 phosphorylation site [posttranslational modification] 373384009781 intermolecular recognition site; other site 373384009782 dimerization interface [polypeptide binding]; other site 373384009783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384009784 DNA binding site [nucleotide binding] 373384009785 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 373384009786 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 373384009787 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 373384009788 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 373384009789 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 373384009790 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 373384009791 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 373384009792 RNA binding site [nucleotide binding]; other site 373384009793 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 373384009794 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 373384009795 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 373384009796 G1 box; other site 373384009797 GTP/Mg2+ binding site [chemical binding]; other site 373384009798 Switch I region; other site 373384009799 G2 box; other site 373384009800 G3 box; other site 373384009801 Switch II region; other site 373384009802 G4 box; other site 373384009803 G5 box; other site 373384009804 Nucleoside recognition; Region: Gate; pfam07670 373384009805 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 373384009806 Nucleoside recognition; Region: Gate; pfam07670 373384009807 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 373384009808 putative transposase; Provisional; Region: PRK09857 373384009809 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 373384009810 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384009811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384009812 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384009813 HTH-like domain; Region: HTH_21; pfam13276 373384009814 Integrase core domain; Region: rve; pfam00665 373384009815 Integrase core domain; Region: rve_3; pfam13683 373384009816 PemK-like protein; Region: PemK; pfam02452 373384009817 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 373384009818 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 373384009819 DNA utilization protein GntX; Provisional; Region: PRK11595 373384009820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384009821 active site 373384009822 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 373384009823 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 373384009824 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 373384009825 high-affinity gluconate transporter; Provisional; Region: PRK14984 373384009826 gluconate transporter; Region: gntP; TIGR00791 373384009827 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 373384009828 4-alpha-glucanotransferase; Region: malQ; TIGR00217 373384009829 maltodextrin phosphorylase; Provisional; Region: PRK14985 373384009830 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 373384009831 homodimer interface [polypeptide binding]; other site 373384009832 active site pocket [active] 373384009833 transcriptional regulator MalT; Provisional; Region: PRK04841 373384009834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384009835 DNA binding residues [nucleotide binding] 373384009836 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 373384009837 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 373384009838 putative active site [active] 373384009839 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 373384009840 hypothetical protein; Reviewed; Region: PRK09588 373384009841 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 373384009842 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 373384009843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384009844 Walker A motif; other site 373384009845 ATP binding site [chemical binding]; other site 373384009846 Walker B motif; other site 373384009847 arginine finger; other site 373384009848 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 373384009849 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 373384009850 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384009851 intramembrane serine protease GlpG; Provisional; Region: PRK10907 373384009852 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 373384009853 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 373384009854 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 373384009855 active site residue [active] 373384009856 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 373384009857 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384009858 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384009859 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384009860 glycogen phosphorylase; Provisional; Region: PRK14986 373384009861 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 373384009862 homodimer interface [polypeptide binding]; other site 373384009863 active site pocket [active] 373384009864 glycogen synthase; Provisional; Region: glgA; PRK00654 373384009865 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 373384009866 ADP-binding pocket [chemical binding]; other site 373384009867 homodimer interface [polypeptide binding]; other site 373384009868 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 373384009869 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 373384009870 ligand binding site; other site 373384009871 oligomer interface; other site 373384009872 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 373384009873 sulfate 1 binding site; other site 373384009874 glycogen debranching enzyme; Provisional; Region: PRK03705 373384009875 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 373384009876 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 373384009877 active site 373384009878 catalytic site [active] 373384009879 glycogen branching enzyme; Provisional; Region: PRK05402 373384009880 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 373384009881 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 373384009882 active site 373384009883 catalytic site [active] 373384009884 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 373384009885 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 373384009886 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 373384009887 putative antibiotic transporter; Provisional; Region: PRK10739 373384009888 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 373384009889 ATP-binding site [chemical binding]; other site 373384009890 Gluconate-6-phosphate binding site [chemical binding]; other site 373384009891 Shikimate kinase; Region: SKI; pfam01202 373384009892 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 373384009893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384009894 DNA binding site [nucleotide binding] 373384009895 domain linker motif; other site 373384009896 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 373384009897 putative ligand binding site [chemical binding]; other site 373384009898 putative dimerization interface [polypeptide binding]; other site 373384009899 Pirin-related protein [General function prediction only]; Region: COG1741 373384009900 Pirin; Region: Pirin; pfam02678 373384009901 putative oxidoreductase; Provisional; Region: PRK10206 373384009902 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 373384009903 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 373384009904 putative acetyltransferase YhhY; Provisional; Region: PRK10140 373384009905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384009906 Coenzyme A binding pocket [chemical binding]; other site 373384009907 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 373384009908 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 373384009909 hypothetical protein; Provisional; Region: PRK10350 373384009910 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 373384009911 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 373384009912 putative active site [active] 373384009913 catalytic site [active] 373384009914 putative metal binding site [ion binding]; other site 373384009915 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373384009916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384009917 dimer interface [polypeptide binding]; other site 373384009918 conserved gate region; other site 373384009919 putative PBP binding loops; other site 373384009920 ABC-ATPase subunit interface; other site 373384009921 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 373384009922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384009923 dimer interface [polypeptide binding]; other site 373384009924 conserved gate region; other site 373384009925 putative PBP binding loops; other site 373384009926 ABC-ATPase subunit interface; other site 373384009927 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 373384009928 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 373384009929 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 373384009930 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 373384009931 Walker A/P-loop; other site 373384009932 ATP binding site [chemical binding]; other site 373384009933 Q-loop/lid; other site 373384009934 ABC transporter signature motif; other site 373384009935 Walker B; other site 373384009936 D-loop; other site 373384009937 H-loop/switch region; other site 373384009938 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 373384009939 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 373384009940 Walker A/P-loop; other site 373384009941 ATP binding site [chemical binding]; other site 373384009942 Q-loop/lid; other site 373384009943 ABC transporter signature motif; other site 373384009944 Walker B; other site 373384009945 D-loop; other site 373384009946 H-loop/switch region; other site 373384009947 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 373384009948 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 373384009949 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 373384009950 TM-ABC transporter signature motif; other site 373384009951 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384009952 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 373384009953 TM-ABC transporter signature motif; other site 373384009954 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 373384009955 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 373384009956 dimerization interface [polypeptide binding]; other site 373384009957 ligand binding site [chemical binding]; other site 373384009958 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 373384009959 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 373384009960 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 373384009961 dimerization interface [polypeptide binding]; other site 373384009962 ligand binding site [chemical binding]; other site 373384009963 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 373384009964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 373384009965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 373384009966 DNA binding residues [nucleotide binding] 373384009967 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 373384009968 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 373384009969 cell division protein FtsE; Provisional; Region: PRK10908 373384009970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384009971 Walker A/P-loop; other site 373384009972 ATP binding site [chemical binding]; other site 373384009973 Q-loop/lid; other site 373384009974 ABC transporter signature motif; other site 373384009975 Walker B; other site 373384009976 D-loop; other site 373384009977 H-loop/switch region; other site 373384009978 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 373384009979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384009980 S-adenosylmethionine binding site [chemical binding]; other site 373384009981 hypothetical protein; Provisional; Region: PRK10910 373384009982 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 373384009983 Predicted membrane protein [Function unknown]; Region: COG3714 373384009984 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 373384009985 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 373384009986 metal-binding site [ion binding] 373384009987 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373384009988 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 373384009989 CPxP motif; other site 373384009990 hypothetical protein; Provisional; Region: PRK11212 373384009991 hypothetical protein; Provisional; Region: PRK11615 373384009992 major facilitator superfamily transporter; Provisional; Region: PRK05122 373384009993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384009994 putative substrate translocation pore; other site 373384009995 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 373384009996 Domain of unknown function DUF20; Region: UPF0118; pfam01594 373384009997 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 373384009998 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 373384009999 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 373384010000 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 373384010001 substrate binding site [chemical binding]; other site 373384010002 nickel transporter permease NikB; Provisional; Region: PRK10352 373384010003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384010004 dimer interface [polypeptide binding]; other site 373384010005 conserved gate region; other site 373384010006 putative PBP binding loops; other site 373384010007 ABC-ATPase subunit interface; other site 373384010008 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 373384010009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384010010 dimer interface [polypeptide binding]; other site 373384010011 conserved gate region; other site 373384010012 putative PBP binding loops; other site 373384010013 ABC-ATPase subunit interface; other site 373384010014 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 373384010015 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384010016 Walker A/P-loop; other site 373384010017 ATP binding site [chemical binding]; other site 373384010018 Q-loop/lid; other site 373384010019 ABC transporter signature motif; other site 373384010020 Walker B; other site 373384010021 D-loop; other site 373384010022 H-loop/switch region; other site 373384010023 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 373384010024 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 373384010025 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384010026 Walker A/P-loop; other site 373384010027 ATP binding site [chemical binding]; other site 373384010028 Q-loop/lid; other site 373384010029 ABC transporter signature motif; other site 373384010030 Walker B; other site 373384010031 D-loop; other site 373384010032 H-loop/switch region; other site 373384010033 nickel responsive regulator; Provisional; Region: PRK02967 373384010034 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 373384010035 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 373384010036 HicB family; Region: HicB; pfam05534 373384010037 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 373384010038 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 373384010039 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373384010040 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 373384010041 Walker A/P-loop; other site 373384010042 ATP binding site [chemical binding]; other site 373384010043 Q-loop/lid; other site 373384010044 ABC transporter signature motif; other site 373384010045 Walker B; other site 373384010046 D-loop; other site 373384010047 H-loop/switch region; other site 373384010048 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 373384010049 Walker A/P-loop; other site 373384010050 ATP binding site [chemical binding]; other site 373384010051 Q-loop/lid; other site 373384010052 ABC transporter signature motif; other site 373384010053 Walker B; other site 373384010054 D-loop; other site 373384010055 H-loop/switch region; other site 373384010056 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 373384010057 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 373384010058 HlyD family secretion protein; Region: HlyD; pfam00529 373384010059 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384010060 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384010061 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 373384010062 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 373384010063 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 373384010064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 373384010065 DNA binding site [nucleotide binding] 373384010066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373384010067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384010068 DNA binding residues [nucleotide binding] 373384010069 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 373384010070 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384010071 PapC C-terminal domain; Region: PapC_C; pfam13953 373384010072 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384010073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010074 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384010075 HTH-like domain; Region: HTH_21; pfam13276 373384010076 Integrase core domain; Region: rve; pfam00665 373384010077 Integrase core domain; Region: rve_3; pfam13683 373384010078 PapC N-terminal domain; Region: PapC_N; pfam13954 373384010079 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 373384010080 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384010081 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 373384010082 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384010083 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384010084 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373384010085 O-Antigen ligase; Region: Wzy_C; pfam04932 373384010086 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 373384010087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010088 Transposase; Region: HTH_Tnp_1; pfam01527 373384010089 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010090 Predicted flavoproteins [General function prediction only]; Region: COG2081 373384010091 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 373384010092 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 373384010093 universal stress protein UspB; Provisional; Region: PRK04960 373384010094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373384010095 Ligand Binding Site [chemical binding]; other site 373384010096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384010097 S-adenosylmethionine binding site [chemical binding]; other site 373384010098 oligopeptidase A; Provisional; Region: PRK10911 373384010099 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 373384010100 active site 373384010101 Zn binding site [ion binding]; other site 373384010102 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 373384010103 glutathione reductase; Validated; Region: PRK06116 373384010104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373384010105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384010106 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373384010107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384010108 dimerization interface [polypeptide binding]; other site 373384010109 putative DNA binding site [nucleotide binding]; other site 373384010110 putative Zn2+ binding site [ion binding]; other site 373384010111 arsenical pump membrane protein; Provisional; Region: PRK15445 373384010112 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 373384010113 transmembrane helices; other site 373384010114 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 373384010115 ArsC family; Region: ArsC; pfam03960 373384010116 catalytic residues [active] 373384010117 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010118 Predicted permeases [General function prediction only]; Region: COG0701 373384010119 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 373384010120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373384010121 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384010122 DNA binding residues [nucleotide binding] 373384010123 dimerization interface [polypeptide binding]; other site 373384010124 acid-resistance protein; Provisional; Region: hdeB; PRK11566 373384010125 acid-resistance protein; Provisional; Region: PRK10208 373384010126 acid-resistance membrane protein; Provisional; Region: PRK10209 373384010127 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 373384010128 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 373384010129 pyruvate kinase; Provisional; Region: PRK05826 373384010130 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010132 Helix-turn-helix domain; Region: HTH_28; pfam13518 373384010133 Helix-turn-helix domain; Region: HTH_28; pfam13518 373384010134 putative transposase OrfB; Reviewed; Region: PHA02517 373384010135 HTH-like domain; Region: HTH_21; pfam13276 373384010136 Integrase core domain; Region: rve; pfam00665 373384010137 Integrase core domain; Region: rve_2; pfam13333 373384010138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 373384010139 DNA-binding site [nucleotide binding]; DNA binding site 373384010140 RNA-binding motif; other site 373384010141 Predicted transcriptional regulator [Transcription]; Region: COG2944 373384010142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384010143 non-specific DNA binding site [nucleotide binding]; other site 373384010144 salt bridge; other site 373384010145 sequence-specific DNA binding site [nucleotide binding]; other site 373384010146 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 373384010147 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 373384010148 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 373384010149 dimerization interface [polypeptide binding]; other site 373384010150 ligand binding site [chemical binding]; other site 373384010151 NADP binding site [chemical binding]; other site 373384010152 catalytic site [active] 373384010153 putative outer membrane lipoprotein; Provisional; Region: PRK10510 373384010154 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 373384010155 ligand binding site [chemical binding]; other site 373384010156 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 373384010157 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 373384010158 molybdopterin cofactor binding site [chemical binding]; other site 373384010159 substrate binding site [chemical binding]; other site 373384010160 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 373384010161 molybdopterin cofactor binding site; other site 373384010162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373384010163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384010164 Coenzyme A binding pocket [chemical binding]; other site 373384010165 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 373384010166 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 373384010167 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 373384010168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384010169 putative substrate translocation pore; other site 373384010170 phosphoethanolamine transferase; Provisional; Region: PRK11560 373384010171 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 373384010172 Sulfatase; Region: Sulfatase; pfam00884 373384010173 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 373384010174 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 373384010175 peptide binding site [polypeptide binding]; other site 373384010176 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 373384010177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384010178 dimer interface [polypeptide binding]; other site 373384010179 conserved gate region; other site 373384010180 putative PBP binding loops; other site 373384010181 ABC-ATPase subunit interface; other site 373384010182 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 373384010183 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384010184 Walker A/P-loop; other site 373384010185 ATP binding site [chemical binding]; other site 373384010186 Q-loop/lid; other site 373384010187 ABC transporter signature motif; other site 373384010188 Walker B; other site 373384010189 D-loop; other site 373384010190 H-loop/switch region; other site 373384010191 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 373384010192 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 373384010193 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 373384010194 Walker A/P-loop; other site 373384010195 ATP binding site [chemical binding]; other site 373384010196 Q-loop/lid; other site 373384010197 ABC transporter signature motif; other site 373384010198 Walker B; other site 373384010199 D-loop; other site 373384010200 H-loop/switch region; other site 373384010201 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 373384010202 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 373384010203 serine transporter; Region: stp; TIGR00814 373384010204 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 373384010205 Protein of unknown function (DUF2636); Region: DUF2636; cl11897 373384010206 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010207 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 373384010208 cell division protein; Provisional; Region: PRK10037 373384010209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 373384010210 cellulose synthase regulator protein; Provisional; Region: PRK11114 373384010211 endo-1,4-D-glucanase; Provisional; Region: PRK11097 373384010212 putative diguanylate cyclase; Provisional; Region: PRK13561 373384010213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 373384010214 metal binding site [ion binding]; metal-binding site 373384010215 active site 373384010216 I-site; other site 373384010217 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384010218 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 373384010219 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 373384010220 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 373384010221 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 373384010222 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384010223 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 373384010224 substrate binding site [chemical binding]; other site 373384010225 ATP binding site [chemical binding]; other site 373384010226 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384010227 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 373384010228 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 373384010229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384010230 metabolite-proton symporter; Region: 2A0106; TIGR00883 373384010231 putative substrate translocation pore; other site 373384010232 inner membrane protein YhjD; Region: TIGR00766 373384010233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373384010234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384010235 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 373384010236 putative effector binding pocket; other site 373384010237 putative dimerization interface [polypeptide binding]; other site 373384010238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373384010239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384010240 DNA binding residues [nucleotide binding] 373384010241 dimerization interface [polypeptide binding]; other site 373384010242 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384010243 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384010244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384010245 trehalase; Provisional; Region: treF; PRK13270 373384010246 Trehalase; Region: Trehalase; pfam01204 373384010247 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010248 Predicted membrane protein [Function unknown]; Region: COG3152 373384010249 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 373384010250 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 373384010251 triosephosphate isomerase; Provisional; Region: PRK14567 373384010252 substrate binding site [chemical binding]; other site 373384010253 dimer interface [polypeptide binding]; other site 373384010254 catalytic triad [active] 373384010255 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 373384010256 sulfate transporter subunit; Provisional; Region: PRK10752 373384010257 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 373384010258 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 373384010259 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 373384010260 active site 373384010261 ADP/pyrophosphate binding site [chemical binding]; other site 373384010262 dimerization interface [polypeptide binding]; other site 373384010263 allosteric effector site; other site 373384010264 fructose-1,6-bisphosphate binding site; other site 373384010265 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 373384010266 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 373384010267 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 373384010268 dimer interface [polypeptide binding]; other site 373384010269 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 373384010270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384010271 intermolecular recognition site; other site 373384010272 active site 373384010273 dimerization interface [polypeptide binding]; other site 373384010274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384010275 DNA binding site [nucleotide binding] 373384010276 two-component sensor protein; Provisional; Region: cpxA; PRK09470 373384010277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384010278 dimerization interface [polypeptide binding]; other site 373384010279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384010280 dimer interface [polypeptide binding]; other site 373384010281 phosphorylation site [posttranslational modification] 373384010282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384010283 ATP binding site [chemical binding]; other site 373384010284 Mg2+ binding site [ion binding]; other site 373384010285 G-X-G motif; other site 373384010286 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 373384010287 MOSC domain; Region: MOSC; pfam03473 373384010288 3-alpha domain; Region: 3-alpha; pfam03475 373384010289 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384010290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010291 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384010292 HTH-like domain; Region: HTH_21; pfam13276 373384010293 Integrase core domain; Region: rve; pfam00665 373384010294 Integrase core domain; Region: rve_3; pfam13683 373384010295 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 373384010296 superoxide dismutase; Provisional; Region: PRK10925 373384010297 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 373384010298 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 373384010299 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 373384010300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384010301 transcriptional activator RhaS; Provisional; Region: PRK13503 373384010302 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 373384010303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384010304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384010305 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 373384010306 N- and C-terminal domain interface [polypeptide binding]; other site 373384010307 active site 373384010308 putative catalytic site [active] 373384010309 metal binding site [ion binding]; metal-binding site 373384010310 ATP binding site [chemical binding]; other site 373384010311 rhamnulokinase; Provisional; Region: rhaB; PRK10640 373384010312 carbohydrate binding site [chemical binding]; other site 373384010313 L-rhamnose isomerase; Provisional; Region: PRK01076 373384010314 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 373384010315 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 373384010316 active site 373384010317 intersubunit interface [polypeptide binding]; other site 373384010318 Zn2+ binding site [ion binding]; other site 373384010319 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 373384010320 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 373384010321 active site 373384010322 phosphorylation site [posttranslational modification] 373384010323 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 373384010324 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 373384010325 active site 373384010326 P-loop; other site 373384010327 phosphorylation site [posttranslational modification] 373384010328 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 373384010329 putative peptidase; Provisional; Region: PRK09864 373384010330 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 373384010331 oligomer interface [polypeptide binding]; other site 373384010332 active site 373384010333 metal binding site [ion binding]; metal-binding site 373384010334 HTH domain; Region: HTH_11; pfam08279 373384010335 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010336 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 373384010337 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 373384010338 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 373384010339 [4Fe-4S] binding site [ion binding]; other site 373384010340 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 373384010341 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 373384010342 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 373384010343 molybdopterin cofactor binding site; other site 373384010344 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 373384010345 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 373384010346 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 373384010347 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 373384010348 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 373384010349 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 373384010350 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 373384010351 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384010353 Coenzyme A binding pocket [chemical binding]; other site 373384010354 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 373384010355 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 373384010356 putative active site [active] 373384010357 dimerization interface [polypeptide binding]; other site 373384010358 putative tRNAtyr binding site [nucleotide binding]; other site 373384010359 hypothetical protein; Reviewed; Region: PRK01637 373384010360 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 373384010361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384010362 motif II; other site 373384010363 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 373384010364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384010365 putative DNA binding site [nucleotide binding]; other site 373384010366 putative Zn2+ binding site [ion binding]; other site 373384010367 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384010368 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384010369 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 373384010370 substrate binding site [chemical binding]; other site 373384010371 ATP binding site [chemical binding]; other site 373384010372 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 373384010373 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 373384010374 Class I aldolases; Region: Aldolase_Class_I; cl17187 373384010375 catalytic residue [active] 373384010376 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 373384010377 dimerization interface [polypeptide binding]; other site 373384010378 putative active cleft [active] 373384010379 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 373384010380 active site 373384010381 catalytic residues [active] 373384010382 alpha-glucosidase; Provisional; Region: PRK10426 373384010383 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 373384010384 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 373384010385 putative active site [active] 373384010386 putative catalytic site [active] 373384010387 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 373384010388 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 373384010389 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 373384010390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384010391 putative substrate translocation pore; other site 373384010392 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 373384010393 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384010395 putative substrate translocation pore; other site 373384010396 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 373384010397 transcriptional regulator protein; Region: phnR; TIGR03337 373384010398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384010399 DNA-binding site [nucleotide binding]; DNA binding site 373384010400 UTRA domain; Region: UTRA; pfam07702 373384010401 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384010402 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384010403 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384010404 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 373384010405 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373384010406 G2 box; other site 373384010407 Switch I region; other site 373384010408 G3 box; other site 373384010409 Switch II region; other site 373384010410 GTP/Mg2+ binding site [chemical binding]; other site 373384010411 G4 box; other site 373384010412 G5 box; other site 373384010413 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 373384010414 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 373384010415 glutamine synthetase; Provisional; Region: glnA; PRK09469 373384010416 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 373384010417 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 373384010418 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 373384010419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 373384010420 putative active site [active] 373384010421 heme pocket [chemical binding]; other site 373384010422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384010423 dimer interface [polypeptide binding]; other site 373384010424 phosphorylation site [posttranslational modification] 373384010425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384010426 ATP binding site [chemical binding]; other site 373384010427 Mg2+ binding site [ion binding]; other site 373384010428 G-X-G motif; other site 373384010429 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 373384010430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384010431 active site 373384010432 phosphorylation site [posttranslational modification] 373384010433 intermolecular recognition site; other site 373384010434 dimerization interface [polypeptide binding]; other site 373384010435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384010436 Walker A motif; other site 373384010437 ATP binding site [chemical binding]; other site 373384010438 Walker B motif; other site 373384010439 arginine finger; other site 373384010440 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 373384010441 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 373384010442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384010443 FeS/SAM binding site; other site 373384010444 HemN C-terminal domain; Region: HemN_C; pfam06969 373384010445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 373384010446 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 373384010447 G1 box; other site 373384010448 GTP/Mg2+ binding site [chemical binding]; other site 373384010449 Switch I region; other site 373384010450 G2 box; other site 373384010451 G3 box; other site 373384010452 Switch II region; other site 373384010453 G4 box; other site 373384010454 G5 box; other site 373384010455 DNA polymerase I; Provisional; Region: PRK05755 373384010456 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 373384010457 active site 373384010458 metal binding site 1 [ion binding]; metal-binding site 373384010459 putative 5' ssDNA interaction site; other site 373384010460 metal binding site 3; metal-binding site 373384010461 metal binding site 2 [ion binding]; metal-binding site 373384010462 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 373384010463 putative DNA binding site [nucleotide binding]; other site 373384010464 putative metal binding site [ion binding]; other site 373384010465 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 373384010466 active site 373384010467 catalytic site [active] 373384010468 substrate binding site [chemical binding]; other site 373384010469 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 373384010470 active site 373384010471 DNA binding site [nucleotide binding] 373384010472 catalytic site [active] 373384010473 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 373384010474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 373384010475 putative acyl-acceptor binding pocket; other site 373384010476 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010477 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 373384010478 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 373384010479 catalytic residues [active] 373384010480 hinge region; other site 373384010481 alpha helical domain; other site 373384010482 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 373384010483 serine/threonine protein kinase; Provisional; Region: PRK11768 373384010484 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 373384010485 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 373384010486 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 373384010487 GTP binding site; other site 373384010488 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 373384010489 Walker A motif; other site 373384010490 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 373384010491 potassium transporter; Provisional; Region: PRK10750 373384010492 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 373384010493 hypothetical protein; Provisional; Region: PRK11568 373384010494 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 373384010495 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 373384010496 proline dipeptidase; Provisional; Region: PRK13607 373384010497 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 373384010498 active site 373384010499 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 373384010500 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 373384010501 substrate binding site [chemical binding]; other site 373384010502 oxyanion hole (OAH) forming residues; other site 373384010503 trimer interface [polypeptide binding]; other site 373384010504 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 373384010505 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 373384010506 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 373384010507 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 373384010508 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 373384010509 dimer interface [polypeptide binding]; other site 373384010510 active site 373384010511 FMN reductase; Validated; Region: fre; PRK08051 373384010512 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 373384010513 FAD binding pocket [chemical binding]; other site 373384010514 FAD binding motif [chemical binding]; other site 373384010515 phosphate binding motif [ion binding]; other site 373384010516 beta-alpha-beta structure motif; other site 373384010517 NAD binding pocket [chemical binding]; other site 373384010518 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 373384010519 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 373384010520 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 373384010521 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 373384010522 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 373384010523 active site 373384010524 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 373384010525 sec-independent translocase; Provisional; Region: PRK01770 373384010526 sec-independent translocase; Provisional; Region: tatB; PRK00404 373384010527 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 373384010528 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 373384010529 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 373384010530 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 373384010531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 373384010532 SCP-2 sterol transfer family; Region: SCP2; pfam02036 373384010533 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 373384010534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384010535 S-adenosylmethionine binding site [chemical binding]; other site 373384010536 DNA recombination protein RmuC; Provisional; Region: PRK10361 373384010537 RmuC family; Region: RmuC; pfam02646 373384010538 uridine phosphorylase; Provisional; Region: PRK11178 373384010539 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 373384010540 Dienelactone hydrolase family; Region: DLH; pfam01738 373384010541 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 373384010542 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 373384010543 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 373384010544 THF binding site; other site 373384010545 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 373384010546 substrate binding site [chemical binding]; other site 373384010547 THF binding site; other site 373384010548 zinc-binding site [ion binding]; other site 373384010549 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 373384010550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384010551 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 373384010552 putative dimerization interface [polypeptide binding]; other site 373384010553 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 373384010554 EamA-like transporter family; Region: EamA; pfam00892 373384010555 putative hydrolase; Provisional; Region: PRK10976 373384010556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384010557 active site 373384010558 motif I; other site 373384010559 motif II; other site 373384010560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384010561 lysophospholipase L2; Provisional; Region: PRK10749 373384010562 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373384010563 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 373384010564 threonine efflux system; Provisional; Region: PRK10229 373384010565 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 373384010566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384010567 ATP binding site [chemical binding]; other site 373384010568 putative Mg++ binding site [ion binding]; other site 373384010569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384010570 nucleotide binding region [chemical binding]; other site 373384010571 ATP-binding site [chemical binding]; other site 373384010572 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 373384010573 Helicase and RNase D C-terminal; Region: HRDC; smart00341 373384010574 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 373384010575 dimerization interface [polypeptide binding]; other site 373384010576 substrate binding site [chemical binding]; other site 373384010577 active site 373384010578 calcium binding site [ion binding]; other site 373384010579 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 373384010580 CoenzymeA binding site [chemical binding]; other site 373384010581 subunit interaction site [polypeptide binding]; other site 373384010582 PHB binding site; other site 373384010583 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 373384010584 EamA-like transporter family; Region: EamA; cl17759 373384010585 hypothetical protein; Provisional; Region: PRK11371 373384010586 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 373384010587 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 373384010588 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 373384010589 Cl binding site [ion binding]; other site 373384010590 oligomer interface [polypeptide binding]; other site 373384010591 Predicted periplasmic protein [Function unknown]; Region: COG3698 373384010592 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384010593 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384010594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384010595 Predicted periplasmic protein [Function unknown]; Region: COG3698 373384010596 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 373384010597 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 373384010598 Part of AAA domain; Region: AAA_19; pfam13245 373384010599 Family description; Region: UvrD_C_2; pfam13538 373384010600 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 373384010601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384010602 motif II; other site 373384010603 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 373384010604 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384010605 active site 373384010606 DNA binding site [nucleotide binding] 373384010607 Int/Topo IB signature motif; other site 373384010608 hypothetical protein; Provisional; Region: PRK10963 373384010609 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 373384010610 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 373384010611 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 373384010612 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 373384010613 DKNYY family; Region: DKNYY; pfam13644 373384010614 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 373384010615 putative iron binding site [ion binding]; other site 373384010616 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 373384010617 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 373384010618 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 373384010619 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 373384010620 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 373384010621 domain interfaces; other site 373384010622 active site 373384010623 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 373384010624 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 373384010625 active site 373384010626 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 373384010627 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 373384010628 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 373384010629 HemY protein N-terminus; Region: HemY_N; pfam07219 373384010630 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384010631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010632 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384010633 HTH-like domain; Region: HTH_21; pfam13276 373384010634 Integrase core domain; Region: rve; pfam00665 373384010635 Integrase core domain; Region: rve_3; pfam13683 373384010636 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 373384010637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384010638 FeS/SAM binding site; other site 373384010639 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 373384010640 putative transport protein YifK; Provisional; Region: PRK10746 373384010641 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 373384010642 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 373384010643 putative common antigen polymerase; Provisional; Region: PRK02975 373384010644 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 373384010645 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 373384010646 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 373384010647 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 373384010648 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 373384010649 inhibitor-cofactor binding pocket; inhibition site 373384010650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384010651 catalytic residue [active] 373384010652 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 373384010653 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 373384010654 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 373384010655 substrate binding site; other site 373384010656 tetramer interface; other site 373384010657 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 373384010658 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 373384010659 NAD binding site [chemical binding]; other site 373384010660 substrate binding site [chemical binding]; other site 373384010661 homodimer interface [polypeptide binding]; other site 373384010662 active site 373384010663 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 373384010664 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 373384010665 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 373384010666 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 373384010667 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 373384010668 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 373384010669 active site 373384010670 homodimer interface [polypeptide binding]; other site 373384010671 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 373384010672 Chain length determinant protein; Region: Wzz; pfam02706 373384010673 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 373384010674 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 373384010675 Mg++ binding site [ion binding]; other site 373384010676 putative catalytic motif [active] 373384010677 substrate binding site [chemical binding]; other site 373384010678 transcription termination factor Rho; Provisional; Region: rho; PRK09376 373384010679 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 373384010680 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 373384010681 RNA binding site [nucleotide binding]; other site 373384010682 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 373384010683 multimer interface [polypeptide binding]; other site 373384010684 Walker A motif; other site 373384010685 ATP binding site [chemical binding]; other site 373384010686 Walker B motif; other site 373384010687 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 373384010688 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 373384010689 catalytic residues [active] 373384010690 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 373384010691 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 373384010692 ATP binding site [chemical binding]; other site 373384010693 Mg++ binding site [ion binding]; other site 373384010694 motif III; other site 373384010695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384010696 nucleotide binding region [chemical binding]; other site 373384010697 ATP-binding site [chemical binding]; other site 373384010698 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 373384010699 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 373384010700 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 373384010701 Part of AAA domain; Region: AAA_19; pfam13245 373384010702 Family description; Region: UvrD_C_2; pfam13538 373384010703 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 373384010704 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 373384010705 ketol-acid reductoisomerase; Validated; Region: PRK05225 373384010706 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 373384010707 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 373384010708 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 373384010709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384010710 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 373384010711 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 373384010712 putative dimerization interface [polypeptide binding]; other site 373384010713 threonine dehydratase; Reviewed; Region: PRK09224 373384010714 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 373384010715 tetramer interface [polypeptide binding]; other site 373384010716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384010717 catalytic residue [active] 373384010718 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 373384010719 putative Ile/Val binding site [chemical binding]; other site 373384010720 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 373384010721 putative Ile/Val binding site [chemical binding]; other site 373384010722 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 373384010723 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 373384010724 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 373384010725 homodimer interface [polypeptide binding]; other site 373384010726 substrate-cofactor binding pocket; other site 373384010727 catalytic residue [active] 373384010728 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 373384010729 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 373384010730 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373384010731 PYR/PP interface [polypeptide binding]; other site 373384010732 dimer interface [polypeptide binding]; other site 373384010733 TPP binding site [chemical binding]; other site 373384010734 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373384010735 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 373384010736 TPP-binding site [chemical binding]; other site 373384010737 dimer interface [polypeptide binding]; other site 373384010738 putative ATP-dependent protease; Provisional; Region: PRK09862 373384010739 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 373384010740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384010741 Walker A motif; other site 373384010742 ATP binding site [chemical binding]; other site 373384010743 Walker B motif; other site 373384010744 arginine finger; other site 373384010745 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 373384010746 hypothetical protein; Provisional; Region: PRK11027 373384010747 transcriptional regulator HdfR; Provisional; Region: PRK03601 373384010748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384010749 LysR substrate binding domain; Region: LysR_substrate; pfam03466 373384010750 dimerization interface [polypeptide binding]; other site 373384010751 Transcriptional regulators [Transcription]; Region: FadR; COG2186 373384010752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384010753 DNA-binding site [nucleotide binding]; DNA binding site 373384010754 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 373384010755 putative transporter; Provisional; Region: PRK10504 373384010756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384010757 putative substrate translocation pore; other site 373384010758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384010759 transcriptional repressor RbsR; Provisional; Region: PRK10423 373384010760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384010761 DNA binding site [nucleotide binding] 373384010762 domain linker motif; other site 373384010763 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 373384010764 dimerization interface [polypeptide binding]; other site 373384010765 ligand binding site [chemical binding]; other site 373384010766 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 373384010767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 373384010768 substrate binding site [chemical binding]; other site 373384010769 dimer interface [polypeptide binding]; other site 373384010770 ATP binding site [chemical binding]; other site 373384010771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384010772 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384010773 TM-ABC transporter signature motif; other site 373384010774 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384010775 D-ribose pyranase; Provisional; Region: PRK11797 373384010776 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 373384010777 potassium uptake protein; Region: kup; TIGR00794 373384010778 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384010779 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384010780 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384010781 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 373384010782 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 373384010783 glutaminase active site [active] 373384010784 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 373384010785 dimer interface [polypeptide binding]; other site 373384010786 active site 373384010787 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 373384010788 dimer interface [polypeptide binding]; other site 373384010789 active site 373384010790 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 373384010791 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 373384010792 Substrate binding site; other site 373384010793 Mg++ binding site; other site 373384010794 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 373384010795 active site 373384010796 substrate binding site [chemical binding]; other site 373384010797 CoA binding site [chemical binding]; other site 373384010798 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 373384010799 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 373384010800 gamma subunit interface [polypeptide binding]; other site 373384010801 epsilon subunit interface [polypeptide binding]; other site 373384010802 LBP interface [polypeptide binding]; other site 373384010803 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 373384010804 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 373384010805 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 373384010806 alpha subunit interaction interface [polypeptide binding]; other site 373384010807 Walker A motif; other site 373384010808 ATP binding site [chemical binding]; other site 373384010809 Walker B motif; other site 373384010810 inhibitor binding site; inhibition site 373384010811 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373384010812 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 373384010813 core domain interface [polypeptide binding]; other site 373384010814 delta subunit interface [polypeptide binding]; other site 373384010815 epsilon subunit interface [polypeptide binding]; other site 373384010816 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 373384010817 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 373384010818 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 373384010819 beta subunit interaction interface [polypeptide binding]; other site 373384010820 Walker A motif; other site 373384010821 ATP binding site [chemical binding]; other site 373384010822 Walker B motif; other site 373384010823 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 373384010824 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 373384010825 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 373384010826 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 373384010827 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 373384010828 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 373384010829 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 373384010830 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 373384010831 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 373384010832 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 373384010833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384010834 S-adenosylmethionine binding site [chemical binding]; other site 373384010835 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 373384010836 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 373384010837 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 373384010838 FMN-binding protein MioC; Provisional; Region: PRK09004 373384010839 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 373384010840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384010841 putative DNA binding site [nucleotide binding]; other site 373384010842 putative Zn2+ binding site [ion binding]; other site 373384010843 AsnC family; Region: AsnC_trans_reg; pfam01037 373384010844 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 373384010845 dimer interface [polypeptide binding]; other site 373384010846 active site 373384010847 hypothetical protein; Provisional; Region: yieM; PRK10997 373384010848 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 373384010849 metal ion-dependent adhesion site (MIDAS); other site 373384010850 regulatory ATPase RavA; Provisional; Region: PRK13531 373384010851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384010852 Walker A motif; other site 373384010853 ATP binding site [chemical binding]; other site 373384010854 Walker B motif; other site 373384010855 arginine finger; other site 373384010856 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 373384010857 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384010858 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384010859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384010860 fimbrial protein; Provisional; Region: lpfA; PRK15289 373384010861 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384010862 HTH-like domain; Region: HTH_21; pfam13276 373384010863 Integrase core domain; Region: rve; pfam00665 373384010864 Integrase core domain; Region: rve_3; pfam13683 373384010865 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384010866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010867 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 373384010868 PapC N-terminal domain; Region: PapC_N; pfam13954 373384010869 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384010870 PapC C-terminal domain; Region: PapC_C; pfam13953 373384010871 Fimbrial protein; Region: Fimbrial; cl01416 373384010872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 373384010873 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 373384010874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384010875 dimer interface [polypeptide binding]; other site 373384010876 conserved gate region; other site 373384010877 putative PBP binding loops; other site 373384010878 ABC-ATPase subunit interface; other site 373384010879 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 373384010880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384010881 dimer interface [polypeptide binding]; other site 373384010882 conserved gate region; other site 373384010883 putative PBP binding loops; other site 373384010884 ABC-ATPase subunit interface; other site 373384010885 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 373384010886 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 373384010887 Walker A/P-loop; other site 373384010888 ATP binding site [chemical binding]; other site 373384010889 Q-loop/lid; other site 373384010890 ABC transporter signature motif; other site 373384010891 Walker B; other site 373384010892 D-loop; other site 373384010893 H-loop/switch region; other site 373384010894 transcriptional regulator PhoU; Provisional; Region: PRK11115 373384010895 PhoU domain; Region: PhoU; pfam01895 373384010896 PhoU domain; Region: PhoU; pfam01895 373384010897 transcriptional antiterminator BglG; Provisional; Region: PRK09772 373384010898 CAT RNA binding domain; Region: CAT_RBD; pfam03123 373384010899 PRD domain; Region: PRD; pfam00874 373384010900 PRD domain; Region: PRD; pfam00874 373384010901 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 373384010902 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 373384010903 active site turn [active] 373384010904 phosphorylation site [posttranslational modification] 373384010905 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 373384010906 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 373384010907 HPr interaction site; other site 373384010908 glycerol kinase (GK) interaction site [polypeptide binding]; other site 373384010909 active site 373384010910 phosphorylation site [posttranslational modification] 373384010911 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 373384010912 beta-galactosidase; Region: BGL; TIGR03356 373384010913 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 373384010914 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 373384010915 trimer interface; other site 373384010916 sugar binding site [chemical binding]; other site 373384010917 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 373384010918 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 373384010919 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 373384010920 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 373384010921 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 373384010922 active site 373384010923 trimer interface [polypeptide binding]; other site 373384010924 allosteric site; other site 373384010925 active site lid [active] 373384010926 hexamer (dimer of trimers) interface [polypeptide binding]; other site 373384010927 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 373384010928 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 373384010929 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 373384010930 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384010931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384010932 Homeodomain-like domain; Region: HTH_23; pfam13384 373384010933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010934 Transposase; Region: HTH_Tnp_1; pfam01527 373384010935 putative inner membrane protein; Provisional; Region: PRK09823 373384010936 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 373384010937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384010938 active site 373384010939 motif I; other site 373384010940 motif II; other site 373384010941 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 373384010942 Predicted flavoprotein [General function prediction only]; Region: COG0431 373384010943 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 373384010944 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 373384010945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384010946 Transposase; Region: HTH_Tnp_1; pfam01527 373384010947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384010948 Integrase core domain; Region: rve; pfam00665 373384010949 Integrase core domain; Region: rve_3; pfam13683 373384010950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384010951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384010952 dimerization interface [polypeptide binding]; other site 373384010953 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 373384010954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384010955 putative substrate translocation pore; other site 373384010956 tryptophan permease TnaB; Provisional; Region: PRK09664 373384010957 aromatic amino acid transport protein; Region: araaP; TIGR00837 373384010958 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 373384010959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 373384010960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373384010961 catalytic residue [active] 373384010962 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 373384010963 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 373384010964 trmE is a tRNA modification GTPase; Region: trmE; cd04164 373384010965 G1 box; other site 373384010966 GTP/Mg2+ binding site [chemical binding]; other site 373384010967 Switch I region; other site 373384010968 G2 box; other site 373384010969 Switch II region; other site 373384010970 G3 box; other site 373384010971 G4 box; other site 373384010972 G5 box; other site 373384010973 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 373384010974 membrane protein insertase; Provisional; Region: PRK01318 373384010975 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 373384010976 ribonuclease P; Reviewed; Region: rnpA; PRK01732 373384010977 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 373384010978 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 373384010979 DnaA N-terminal domain; Region: DnaA_N; pfam11638 373384010980 Bacterial dnaA protein; Region: Bac_DnaA; pfam00308 373384010981 Walker A motif; other site 373384010982 ATP binding site [chemical binding]; other site 373384010983 Walker B motif; other site 373384010984 arginine finger; other site 373384010985 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 373384010986 DnaA box-binding interface [nucleotide binding]; other site 373384010987 DNA polymerase III subunit beta; Validated; Region: PRK05643 373384010988 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 373384010989 putative DNA binding surface [nucleotide binding]; other site 373384010990 dimer interface [polypeptide binding]; other site 373384010991 beta-clamp/clamp loader binding surface; other site 373384010992 beta-clamp/translesion DNA polymerase binding surface; other site 373384010993 recF protein; Region: recf; TIGR00611 373384010994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384010995 Walker A/P-loop; other site 373384010996 ATP binding site [chemical binding]; other site 373384010997 Q-loop/lid; other site 373384010998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384010999 ABC transporter signature motif; other site 373384011000 Walker B; other site 373384011001 D-loop; other site 373384011002 H-loop/switch region; other site 373384011003 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 373384011004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384011005 Mg2+ binding site [ion binding]; other site 373384011006 G-X-G motif; other site 373384011007 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 373384011008 anchoring element; other site 373384011009 dimer interface [polypeptide binding]; other site 373384011010 ATP binding site [chemical binding]; other site 373384011011 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 373384011012 active site 373384011013 putative metal-binding site [ion binding]; other site 373384011014 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 373384011015 hypothetical protein; Provisional; Region: PRK11426 373384011016 sugar phosphate phosphatase; Provisional; Region: PRK10513 373384011017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384011018 active site 373384011019 motif I; other site 373384011020 motif II; other site 373384011021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384011022 hypothetical protein; Provisional; Region: PRK10215 373384011023 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 373384011024 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 373384011025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384011026 D-galactonate transporter; Region: 2A0114; TIGR00893 373384011027 putative substrate translocation pore; other site 373384011028 putative oxidoreductase; Provisional; Region: PRK11445 373384011029 hypothetical protein; Provisional; Region: PRK07236 373384011030 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 373384011031 hypothetical protein; Provisional; Region: PRK11616 373384011032 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373384011033 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 373384011034 putative dimer interface [polypeptide binding]; other site 373384011035 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 373384011036 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 373384011037 putative dimer interface [polypeptide binding]; other site 373384011038 putative transporter; Validated; Region: PRK03818 373384011039 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 373384011040 TrkA-C domain; Region: TrkA_C; pfam02080 373384011041 TrkA-C domain; Region: TrkA_C; pfam02080 373384011042 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 373384011043 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 373384011044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384011045 DNA-binding site [nucleotide binding]; DNA binding site 373384011046 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 373384011047 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 373384011048 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 373384011049 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 373384011050 active site turn [active] 373384011051 phosphorylation site [posttranslational modification] 373384011052 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 373384011053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373384011055 putative transporter; Provisional; Region: PRK10484 373384011056 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 373384011057 Na binding site [ion binding]; other site 373384011058 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 373384011059 Sulfatase; Region: Sulfatase; pfam00884 373384011060 Predicted membrane protein [Function unknown]; Region: COG2149 373384011061 Domain of unknown function (DUF202); Region: DUF202; pfam02656 373384011062 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 373384011063 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 373384011064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384011065 putative substrate translocation pore; other site 373384011066 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 373384011067 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 373384011068 PYR/PP interface [polypeptide binding]; other site 373384011069 dimer interface [polypeptide binding]; other site 373384011070 TPP binding site [chemical binding]; other site 373384011071 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 373384011072 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 373384011073 TPP-binding site [chemical binding]; other site 373384011074 dimer interface [polypeptide binding]; other site 373384011075 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 373384011076 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 373384011077 putative valine binding site [chemical binding]; other site 373384011078 dimer interface [polypeptide binding]; other site 373384011079 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 373384011080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384011081 active site 373384011082 phosphorylation site [posttranslational modification] 373384011083 intermolecular recognition site; other site 373384011084 dimerization interface [polypeptide binding]; other site 373384011085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384011086 DNA binding residues [nucleotide binding] 373384011087 dimerization interface [polypeptide binding]; other site 373384011088 sensory histidine kinase UhpB; Provisional; Region: PRK11644 373384011089 MASE1; Region: MASE1; pfam05231 373384011090 Histidine kinase; Region: HisKA_3; pfam07730 373384011091 regulatory protein UhpC; Provisional; Region: PRK11663 373384011092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384011093 putative substrate translocation pore; other site 373384011094 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 373384011095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384011096 putative substrate translocation pore; other site 373384011097 cryptic adenine deaminase; Provisional; Region: PRK10027 373384011098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 373384011099 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 373384011100 active site 373384011101 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 373384011102 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 373384011103 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 373384011104 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 373384011105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384011106 putative substrate translocation pore; other site 373384011107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384011108 Transposase; Region: HTH_Tnp_1; pfam01527 373384011109 HTH-like domain; Region: HTH_21; pfam13276 373384011110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384011111 Integrase core domain; Region: rve; pfam00665 373384011112 Integrase core domain; Region: rve_3; pfam13683 373384011113 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 373384011114 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373384011115 N-terminal plug; other site 373384011116 ligand-binding site [chemical binding]; other site 373384011117 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 373384011118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 373384011119 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 373384011120 IucA / IucC family; Region: IucA_IucC; pfam04183 373384011121 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 373384011122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 373384011123 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 373384011124 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 373384011125 IucA / IucC family; Region: IucA_IucC; pfam04183 373384011126 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 373384011127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384011128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 373384011129 putative substrate translocation pore; other site 373384011130 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011131 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384011132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384011133 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384011134 HTH-like domain; Region: HTH_21; pfam13276 373384011135 Integrase core domain; Region: rve; pfam00665 373384011136 Integrase core domain; Region: rve_3; pfam13683 373384011137 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384011138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384011139 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384011140 HTH-like domain; Region: HTH_21; pfam13276 373384011141 Integrase core domain; Region: rve; pfam00665 373384011142 Integrase core domain; Region: rve_3; pfam13683 373384011143 Transposase; Region: HTH_Tnp_1; cl17663 373384011144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384011145 Integrase core domain; Region: rve; pfam00665 373384011146 Integrase core domain; Region: rve_3; pfam13683 373384011147 putative transposase OrfB; Reviewed; Region: PHA02517 373384011148 Integrase core domain; Region: rve; pfam00665 373384011149 Integrase core domain; Region: rve_2; pfam13333 373384011150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 373384011151 TPR motif; other site 373384011152 binding surface 373384011153 integrase; Provisional; Region: PRK09692 373384011154 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 373384011155 active site 373384011156 Int/Topo IB signature motif; other site 373384011157 putative alpha-glucosidase; Provisional; Region: PRK10658 373384011158 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 373384011159 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 373384011160 active site 373384011161 homotrimer interface [polypeptide binding]; other site 373384011162 catalytic site [active] 373384011163 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 373384011164 AsmA family; Region: AsmA; pfam05170 373384011165 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 373384011166 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 373384011167 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 373384011168 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 373384011169 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 373384011170 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 373384011171 generic binding surface II; other site 373384011172 ssDNA binding site; other site 373384011173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384011174 ATP binding site [chemical binding]; other site 373384011175 putative Mg++ binding site [ion binding]; other site 373384011176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 373384011177 nucleotide binding region [chemical binding]; other site 373384011178 ATP-binding site [chemical binding]; other site 373384011179 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 373384011180 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 373384011181 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 373384011182 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 373384011183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 373384011184 Zn2+ binding site [ion binding]; other site 373384011185 Mg2+ binding site [ion binding]; other site 373384011186 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 373384011187 synthetase active site [active] 373384011188 NTP binding site [chemical binding]; other site 373384011189 metal binding site [ion binding]; metal-binding site 373384011190 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 373384011191 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 373384011192 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 373384011193 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 373384011194 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 373384011195 catalytic site [active] 373384011196 G-X2-G-X-G-K; other site 373384011197 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 373384011198 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 373384011199 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 373384011200 nucleotide binding pocket [chemical binding]; other site 373384011201 K-X-D-G motif; other site 373384011202 catalytic site [active] 373384011203 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 373384011204 Predicted membrane protein [Function unknown]; Region: COG2860 373384011205 UPF0126 domain; Region: UPF0126; pfam03458 373384011206 UPF0126 domain; Region: UPF0126; pfam03458 373384011207 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 373384011208 BRO family, N-terminal domain; Region: Bro-N; pfam02498 373384011209 hypothetical protein; Provisional; Region: PRK11820 373384011210 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 373384011211 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 373384011212 ribonuclease PH; Reviewed; Region: rph; PRK00173 373384011213 Ribonuclease PH; Region: RNase_PH_bact; cd11362 373384011214 hexamer interface [polypeptide binding]; other site 373384011215 active site 373384011216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 373384011217 active site 373384011218 division inhibitor protein; Provisional; Region: slmA; PRK09480 373384011219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384011220 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 373384011221 trimer interface [polypeptide binding]; other site 373384011222 active site 373384011223 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 373384011224 Flavoprotein; Region: Flavoprotein; pfam02441 373384011225 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 373384011226 hypothetical protein; Reviewed; Region: PRK00024 373384011227 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 373384011228 MPN+ (JAMM) motif; other site 373384011229 Zinc-binding site [ion binding]; other site 373384011230 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 373384011231 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 373384011232 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 373384011233 DNA binding site [nucleotide binding] 373384011234 catalytic residue [active] 373384011235 H2TH interface [polypeptide binding]; other site 373384011236 putative catalytic residues [active] 373384011237 turnover-facilitating residue; other site 373384011238 intercalation triad [nucleotide binding]; other site 373384011239 8OG recognition residue [nucleotide binding]; other site 373384011240 putative reading head residues; other site 373384011241 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 373384011242 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 373384011243 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 373384011244 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 373384011245 active site 373384011246 (T/H)XGH motif; other site 373384011247 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 373384011248 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 373384011249 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 373384011250 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011251 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 373384011252 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 373384011253 putative active site [active] 373384011254 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373384011255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 373384011256 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 373384011257 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 373384011258 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 373384011259 Ligand binding site; other site 373384011260 metal-binding site 373384011261 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 373384011262 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 373384011263 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 373384011264 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 373384011265 Ligand binding site; other site 373384011266 metal-binding site 373384011267 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 373384011268 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 373384011269 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 373384011270 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 373384011271 O-antigen ligase RfaL; Provisional; Region: PRK15487 373384011272 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 373384011273 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 373384011274 putative active site [active] 373384011275 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 373384011276 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 373384011277 putative active site [active] 373384011278 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 373384011279 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 373384011280 NADP binding site [chemical binding]; other site 373384011281 homopentamer interface [polypeptide binding]; other site 373384011282 substrate binding site [chemical binding]; other site 373384011283 active site 373384011284 hypothetical protein; Provisional; Region: PRK11346 373384011285 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 373384011286 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 373384011287 substrate-cofactor binding pocket; other site 373384011288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384011289 catalytic residue [active] 373384011290 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 373384011291 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 373384011292 NAD(P) binding site [chemical binding]; other site 373384011293 putative glycosyl transferase; Provisional; Region: PRK10073 373384011294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 373384011295 active site 373384011296 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011297 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 373384011298 putative active site [active] 373384011299 NodB motif; other site 373384011300 AmiB activator; Provisional; Region: PRK11637 373384011301 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 373384011302 Peptidase family M23; Region: Peptidase_M23; pfam01551 373384011303 phosphoglyceromutase; Provisional; Region: PRK05434 373384011304 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 373384011305 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011306 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 373384011307 active site residue [active] 373384011308 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 373384011309 GSH binding site [chemical binding]; other site 373384011310 catalytic residues [active] 373384011311 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 373384011312 SecA binding site; other site 373384011313 Preprotein binding site; other site 373384011314 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 373384011315 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 373384011316 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 373384011317 serine acetyltransferase; Provisional; Region: cysE; PRK11132 373384011318 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 373384011319 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 373384011320 trimer interface [polypeptide binding]; other site 373384011321 active site 373384011322 substrate binding site [chemical binding]; other site 373384011323 CoA binding site [chemical binding]; other site 373384011324 putative rRNA methylase; Provisional; Region: PRK10358 373384011325 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 373384011326 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 373384011327 phosphate binding site [ion binding]; other site 373384011328 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 373384011329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384011330 DNA-binding site [nucleotide binding]; DNA binding site 373384011331 FCD domain; Region: FCD; pfam07729 373384011332 L-lactate permease; Provisional; Region: PRK10420 373384011333 glycolate transporter; Provisional; Region: PRK09695 373384011334 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 373384011335 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 373384011336 trimer interface [polypeptide binding]; other site 373384011337 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 373384011338 Haemagglutinin; Region: HIM; pfam05662 373384011339 YadA-like C-terminal region; Region: YadA; pfam03895 373384011340 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 373384011341 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 373384011342 trimer interface [polypeptide binding]; other site 373384011343 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 373384011344 trimer interface [polypeptide binding]; other site 373384011345 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 373384011346 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011347 hypothetical protein; Provisional; Region: PRK11020 373384011348 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 373384011349 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 373384011350 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 373384011351 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 373384011352 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 373384011353 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 373384011354 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 373384011355 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 373384011356 active site 373384011357 P-loop; other site 373384011358 phosphorylation site [posttranslational modification] 373384011359 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 373384011360 active site 373384011361 phosphorylation site [posttranslational modification] 373384011362 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 373384011363 HlyD family secretion protein; Region: HlyD; pfam00529 373384011364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384011365 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384011366 putative glutathione S-transferase; Provisional; Region: PRK10357 373384011367 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 373384011368 putative C-terminal domain interface [polypeptide binding]; other site 373384011369 putative GSH binding site (G-site) [chemical binding]; other site 373384011370 putative dimer interface [polypeptide binding]; other site 373384011371 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 373384011372 dimer interface [polypeptide binding]; other site 373384011373 N-terminal domain interface [polypeptide binding]; other site 373384011374 putative substrate binding pocket (H-site) [chemical binding]; other site 373384011375 selenocysteine synthase; Provisional; Region: PRK04311 373384011376 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 373384011377 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 373384011378 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 373384011379 catalytic residue [active] 373384011380 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 373384011381 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 373384011382 G1 box; other site 373384011383 putative GEF interaction site [polypeptide binding]; other site 373384011384 GTP/Mg2+ binding site [chemical binding]; other site 373384011385 Switch I region; other site 373384011386 G2 box; other site 373384011387 G3 box; other site 373384011388 Switch II region; other site 373384011389 G4 box; other site 373384011390 G5 box; other site 373384011391 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 373384011392 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 373384011393 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 373384011394 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 373384011395 putative alcohol dehydrogenase; Provisional; Region: PRK09860 373384011396 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 373384011397 dimer interface [polypeptide binding]; other site 373384011398 active site 373384011399 metal binding site [ion binding]; metal-binding site 373384011400 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 373384011401 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 373384011402 NAD(P) binding site [chemical binding]; other site 373384011403 catalytic residues [active] 373384011404 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 373384011405 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 373384011406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384011407 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384011408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 373384011409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 373384011410 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011411 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 373384011412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 373384011413 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 373384011414 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 373384011415 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 373384011416 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 373384011417 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 373384011418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011419 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 373384011420 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 373384011421 intersubunit interface [polypeptide binding]; other site 373384011422 active site 373384011423 Zn2+ binding site [ion binding]; other site 373384011424 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 373384011425 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 373384011426 AP (apurinic/apyrimidinic) site pocket; other site 373384011427 DNA interaction; other site 373384011428 Metal-binding active site; metal-binding site 373384011429 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 373384011430 active site 373384011431 dimer interface [polypeptide binding]; other site 373384011432 magnesium binding site [ion binding]; other site 373384011433 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 373384011434 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 373384011435 putative N- and C-terminal domain interface [polypeptide binding]; other site 373384011436 putative active site [active] 373384011437 MgATP binding site [chemical binding]; other site 373384011438 catalytic site [active] 373384011439 metal binding site [ion binding]; metal-binding site 373384011440 putative xylulose binding site [chemical binding]; other site 373384011441 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 373384011442 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 373384011443 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 373384011444 DctM-like transporters; Region: DctM; pfam06808 373384011445 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 373384011446 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011447 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 373384011448 Transcriptional regulator [Transcription]; Region: IclR; COG1414 373384011449 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 373384011450 Bacterial transcriptional regulator; Region: IclR; pfam01614 373384011451 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 373384011452 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 373384011453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384011454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384011455 homodimer interface [polypeptide binding]; other site 373384011456 catalytic residue [active] 373384011457 alpha-amylase; Reviewed; Region: malS; PRK09505 373384011458 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 373384011459 active site 373384011460 catalytic site [active] 373384011461 hypothetical protein; Provisional; Region: PRK10356 373384011462 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 373384011463 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 373384011464 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373384011465 Walker A/P-loop; other site 373384011466 ATP binding site [chemical binding]; other site 373384011467 Q-loop/lid; other site 373384011468 ABC transporter signature motif; other site 373384011469 Walker B; other site 373384011470 D-loop; other site 373384011471 H-loop/switch region; other site 373384011472 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 373384011473 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 373384011474 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 373384011475 putative ligand binding site [chemical binding]; other site 373384011476 xylulokinase; Provisional; Region: PRK15027 373384011477 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 373384011478 N- and C-terminal domain interface [polypeptide binding]; other site 373384011479 active site 373384011480 MgATP binding site [chemical binding]; other site 373384011481 catalytic site [active] 373384011482 metal binding site [ion binding]; metal-binding site 373384011483 xylulose binding site [chemical binding]; other site 373384011484 homodimer interface [polypeptide binding]; other site 373384011485 hypothetical protein; Provisional; Region: PRK11403 373384011486 yiaA/B two helix domain; Region: YiaAB; pfam05360 373384011487 hypothetical protein; Provisional; Region: PRK11383 373384011488 yiaA/B two helix domain; Region: YiaAB; pfam05360 373384011489 yiaA/B two helix domain; Region: YiaAB; pfam05360 373384011490 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 373384011491 Acyltransferase family; Region: Acyl_transf_3; pfam01757 373384011492 YsaB-like lipoprotein; Region: YsaB; pfam13983 373384011493 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 373384011494 dimer interface [polypeptide binding]; other site 373384011495 motif 1; other site 373384011496 active site 373384011497 motif 2; other site 373384011498 motif 3; other site 373384011499 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 373384011500 DALR anticodon binding domain; Region: DALR_1; pfam05746 373384011501 anticodon binding site; other site 373384011502 tRNA binding surface [nucleotide binding]; other site 373384011503 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011504 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 373384011505 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 373384011506 Protein export membrane protein; Region: SecD_SecF; cl14618 373384011507 transcriptional regulator YdeO; Provisional; Region: PRK09940 373384011508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011509 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 373384011510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011511 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 373384011512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384011513 catalytic residue [active] 373384011514 Haem-binding domain; Region: Haem_bd; pfam14376 373384011515 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 373384011516 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011517 hypothetical protein; Provisional; Region: PRK09981 373384011518 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 373384011519 Ligand Binding Site [chemical binding]; other site 373384011520 ferredoxin-NADP reductase; Provisional; Region: PRK10926 373384011521 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 373384011522 FAD binding pocket [chemical binding]; other site 373384011523 FAD binding motif [chemical binding]; other site 373384011524 phosphate binding motif [ion binding]; other site 373384011525 beta-alpha-beta structure motif; other site 373384011526 NAD binding pocket [chemical binding]; other site 373384011527 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 373384011528 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 373384011529 putative active site [active] 373384011530 glycerol kinase; Provisional; Region: glpK; PRK00047 373384011531 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 373384011532 N- and C-terminal domain interface [polypeptide binding]; other site 373384011533 homotetramer interface [polypeptide binding]; other site 373384011534 homodimer interface [polypeptide binding]; other site 373384011535 active site 373384011536 glycerol binding site [chemical binding]; other site 373384011537 FBP binding site [chemical binding]; other site 373384011538 MgATP binding site [chemical binding]; other site 373384011539 protein IIAGlc interface [polypeptide binding]; other site 373384011540 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 373384011541 amphipathic channel; other site 373384011542 Asn-Pro-Ala signature motifs; other site 373384011543 septal ring assembly protein ZapB; Provisional; Region: PRK15422 373384011544 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 373384011545 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 373384011546 UbiA prenyltransferase family; Region: UbiA; pfam01040 373384011547 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 373384011548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384011549 Walker A motif; other site 373384011550 ATP binding site [chemical binding]; other site 373384011551 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 373384011552 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 373384011553 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 373384011554 active site 373384011555 HslU subunit interaction site [polypeptide binding]; other site 373384011556 essential cell division protein FtsN; Provisional; Region: PRK10927 373384011557 cell division protein FtsN; Provisional; Region: PRK12757 373384011558 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 373384011559 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 373384011560 dimerization interface [polypeptide binding]; other site 373384011561 ligand binding site [chemical binding]; other site 373384011562 primosome assembly protein PriA; Validated; Region: PRK05580 373384011563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384011564 ATP binding site [chemical binding]; other site 373384011565 putative Mg++ binding site [ion binding]; other site 373384011566 helicase superfamily c-terminal domain; Region: HELICc; smart00490 373384011567 ATP-binding site [chemical binding]; other site 373384011568 hypothetical protein; Provisional; Region: PRK10030 373384011569 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 373384011570 dimerization interface [polypeptide binding]; other site 373384011571 DNA binding site [nucleotide binding] 373384011572 corepressor binding sites; other site 373384011573 cystathionine gamma-synthase; Provisional; Region: PRK08045 373384011574 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 373384011575 homodimer interface [polypeptide binding]; other site 373384011576 substrate-cofactor binding pocket; other site 373384011577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384011578 catalytic residue [active] 373384011579 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 373384011580 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 373384011581 putative catalytic residues [active] 373384011582 putative nucleotide binding site [chemical binding]; other site 373384011583 putative aspartate binding site [chemical binding]; other site 373384011584 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 373384011585 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 373384011586 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 373384011587 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 373384011588 FAD binding site [chemical binding]; other site 373384011589 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 373384011590 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 373384011591 heme binding site [chemical binding]; other site 373384011592 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 373384011593 EamA-like transporter family; Region: EamA; pfam00892 373384011594 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 373384011595 EamA-like transporter family; Region: EamA; pfam00892 373384011596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 373384011597 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 373384011598 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 373384011599 active site 373384011600 P-loop; other site 373384011601 phosphorylation site [posttranslational modification] 373384011602 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 373384011603 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 373384011604 dimer interface [polypeptide binding]; other site 373384011605 active site 373384011606 glycine loop; other site 373384011607 pyruvate formate lyase II activase; Provisional; Region: PRK10076 373384011608 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 373384011609 active site 373384011610 P-loop; other site 373384011611 phosphorylation site [posttranslational modification] 373384011612 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373384011613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011614 hypothetical protein; Provisional; Region: PRK10649 373384011615 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 373384011616 Sulfatase; Region: Sulfatase; pfam00884 373384011617 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 373384011618 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 373384011619 acetylornithine deacetylase; Provisional; Region: PRK05111 373384011620 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 373384011621 metal binding site [ion binding]; metal-binding site 373384011622 putative dimer interface [polypeptide binding]; other site 373384011623 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 373384011624 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 373384011625 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 373384011626 nucleotide binding site [chemical binding]; other site 373384011627 N-acetyl-L-glutamate binding site [chemical binding]; other site 373384011628 argininosuccinate lyase; Provisional; Region: PRK04833 373384011629 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 373384011630 active sites [active] 373384011631 tetramer interface [polypeptide binding]; other site 373384011632 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384011633 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384011634 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384011635 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 373384011636 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 373384011637 putative active site pocket [active] 373384011638 putative metal binding site [ion binding]; other site 373384011639 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011640 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 373384011641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384011642 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 373384011643 dimerization interface [polypeptide binding]; other site 373384011644 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 373384011645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 373384011646 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 373384011647 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 373384011648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384011649 hypothetical protein; Provisional; Region: PRK11056 373384011650 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 373384011651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384011652 S-adenosylmethionine binding site [chemical binding]; other site 373384011653 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 373384011654 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 373384011655 N-terminal plug; other site 373384011656 ligand-binding site [chemical binding]; other site 373384011657 glutamate racemase; Provisional; Region: PRK00865 373384011658 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 373384011659 FAD binding domain; Region: FAD_binding_4; pfam01565 373384011660 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 373384011661 Biotin operon repressor [Transcription]; Region: BirA; COG1654 373384011662 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 373384011663 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 373384011664 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 373384011665 pantothenate kinase; Provisional; Region: PRK05439 373384011666 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 373384011667 ATP-binding site [chemical binding]; other site 373384011668 CoA-binding site [chemical binding]; other site 373384011669 Mg2+-binding site [ion binding]; other site 373384011670 elongation factor Tu; Reviewed; Region: PRK00049 373384011671 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 373384011672 G1 box; other site 373384011673 GEF interaction site [polypeptide binding]; other site 373384011674 GTP/Mg2+ binding site [chemical binding]; other site 373384011675 Switch I region; other site 373384011676 G2 box; other site 373384011677 G3 box; other site 373384011678 Switch II region; other site 373384011679 G4 box; other site 373384011680 G5 box; other site 373384011681 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 373384011682 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 373384011683 Antibiotic Binding Site [chemical binding]; other site 373384011684 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 373384011685 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 373384011686 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 373384011687 putative homodimer interface [polypeptide binding]; other site 373384011688 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 373384011689 heterodimer interface [polypeptide binding]; other site 373384011690 homodimer interface [polypeptide binding]; other site 373384011691 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 373384011692 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 373384011693 23S rRNA interface [nucleotide binding]; other site 373384011694 L7/L12 interface [polypeptide binding]; other site 373384011695 putative thiostrepton binding site; other site 373384011696 L25 interface [polypeptide binding]; other site 373384011697 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 373384011698 mRNA/rRNA interface [nucleotide binding]; other site 373384011699 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 373384011700 23S rRNA interface [nucleotide binding]; other site 373384011701 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 373384011702 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 373384011703 core dimer interface [polypeptide binding]; other site 373384011704 peripheral dimer interface [polypeptide binding]; other site 373384011705 L10 interface [polypeptide binding]; other site 373384011706 L11 interface [polypeptide binding]; other site 373384011707 putative EF-Tu interaction site [polypeptide binding]; other site 373384011708 putative EF-G interaction site [polypeptide binding]; other site 373384011709 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 373384011710 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 373384011711 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 373384011712 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 373384011713 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 373384011714 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 373384011715 RPB3 interaction site [polypeptide binding]; other site 373384011716 RPB1 interaction site [polypeptide binding]; other site 373384011717 RPB11 interaction site [polypeptide binding]; other site 373384011718 RPB10 interaction site [polypeptide binding]; other site 373384011719 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 373384011720 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 373384011721 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 373384011722 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 373384011723 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 373384011724 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 373384011725 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 373384011726 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 373384011727 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 373384011728 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 373384011729 DNA binding site [nucleotide binding] 373384011730 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 373384011731 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 373384011732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384011733 FeS/SAM binding site; other site 373384011734 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 373384011735 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 373384011736 ThiS interaction site; other site 373384011737 putative active site [active] 373384011738 tetramer interface [polypeptide binding]; other site 373384011739 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 373384011740 thiS-thiF/thiG interaction site; other site 373384011741 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 373384011742 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 373384011743 ATP binding site [chemical binding]; other site 373384011744 substrate interface [chemical binding]; other site 373384011745 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 373384011746 thiamine phosphate binding site [chemical binding]; other site 373384011747 active site 373384011748 pyrophosphate binding site [ion binding]; other site 373384011749 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 373384011750 ThiC-associated domain; Region: ThiC-associated; pfam13667 373384011751 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 373384011752 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 373384011753 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 373384011754 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 373384011755 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 373384011756 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 373384011757 putative NADH binding site [chemical binding]; other site 373384011758 putative active site [active] 373384011759 nudix motif; other site 373384011760 putative metal binding site [ion binding]; other site 373384011761 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 373384011762 substrate binding site [chemical binding]; other site 373384011763 active site 373384011764 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 373384011765 Active_site [active] 373384011766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 373384011767 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 373384011768 IHF dimer interface [polypeptide binding]; other site 373384011769 IHF - DNA interface [nucleotide binding]; other site 373384011770 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 373384011771 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 373384011772 dimer interface [polypeptide binding]; other site 373384011773 sensor protein ZraS; Provisional; Region: PRK10364 373384011774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384011775 dimer interface [polypeptide binding]; other site 373384011776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384011777 ATP binding site [chemical binding]; other site 373384011778 Mg2+ binding site [ion binding]; other site 373384011779 G-X-G motif; other site 373384011780 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 373384011781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384011782 active site 373384011783 phosphorylation site [posttranslational modification] 373384011784 intermolecular recognition site; other site 373384011785 dimerization interface [polypeptide binding]; other site 373384011786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384011787 Walker A motif; other site 373384011788 ATP binding site [chemical binding]; other site 373384011789 Walker B motif; other site 373384011790 arginine finger; other site 373384011791 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 373384011792 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 373384011793 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 373384011794 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 373384011795 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 373384011796 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 373384011797 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 373384011798 purine monophosphate binding site [chemical binding]; other site 373384011799 dimer interface [polypeptide binding]; other site 373384011800 putative catalytic residues [active] 373384011801 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 373384011802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 373384011803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384011804 Coenzyme A binding pocket [chemical binding]; other site 373384011805 homoserine O-succinyltransferase; Provisional; Region: PRK05368 373384011806 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 373384011807 proposed active site lysine [active] 373384011808 conserved cys residue [active] 373384011809 isocitrate lyase; Provisional; Region: PRK15063 373384011810 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 373384011811 tetramer interface [polypeptide binding]; other site 373384011812 active site 373384011813 Mg2+/Mn2+ binding site [ion binding]; other site 373384011814 transcriptional repressor IclR; Provisional; Region: PRK11569 373384011815 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 373384011816 Bacterial transcriptional regulator; Region: IclR; pfam01614 373384011817 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 373384011818 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 373384011819 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 373384011820 substrate binding pocket [chemical binding]; other site 373384011821 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 373384011822 B12 binding site [chemical binding]; other site 373384011823 cobalt ligand [ion binding]; other site 373384011824 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 373384011825 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 373384011826 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 373384011827 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 373384011828 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 373384011829 active site pocket [active] 373384011830 oxyanion hole [active] 373384011831 catalytic triad [active] 373384011832 active site nucleophile [active] 373384011833 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 373384011834 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373384011835 putative NAD(P) binding site [chemical binding]; other site 373384011836 catalytic Zn binding site [ion binding]; other site 373384011837 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 373384011838 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 373384011839 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 373384011840 active site 373384011841 phosphorylation site [posttranslational modification] 373384011842 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 373384011843 active pocket/dimerization site; other site 373384011844 active site 373384011845 phosphorylation site [posttranslational modification] 373384011846 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 373384011847 classical (c) SDRs; Region: SDR_c; cd05233 373384011848 NAD(P) binding site [chemical binding]; other site 373384011849 active site 373384011850 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 373384011851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 373384011852 putative DNA binding site [nucleotide binding]; other site 373384011853 putative Zn2+ binding site [ion binding]; other site 373384011854 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 373384011855 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 373384011856 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 373384011857 RNA binding surface [nucleotide binding]; other site 373384011858 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 373384011859 probable active site [active] 373384011860 hypothetical protein; Provisional; Region: PRK10515 373384011861 Integrase core domain; Region: rve_3; pfam13683 373384011862 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384011863 HTH-like domain; Region: HTH_21; pfam13276 373384011864 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384011865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384011866 sensory histidine kinase DcuS; Provisional; Region: PRK11086 373384011867 PAS domain; Region: PAS; smart00091 373384011868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384011869 ATP binding site [chemical binding]; other site 373384011870 Mg2+ binding site [ion binding]; other site 373384011871 G-X-G motif; other site 373384011872 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 373384011873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384011874 active site 373384011875 phosphorylation site [posttranslational modification] 373384011876 intermolecular recognition site; other site 373384011877 dimerization interface [polypeptide binding]; other site 373384011878 Transcriptional regulator; Region: CitT; pfam12431 373384011879 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 373384011880 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 373384011881 fumarate hydratase; Provisional; Region: PRK15389 373384011882 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 373384011883 Fumarase C-terminus; Region: Fumerase_C; pfam05683 373384011884 hypothetical protein; Provisional; Region: PRK09867 373384011885 melibiose:sodium symporter; Provisional; Region: PRK10429 373384011886 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 373384011887 alpha-galactosidase; Provisional; Region: PRK15076 373384011888 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 373384011889 NAD binding site [chemical binding]; other site 373384011890 sugar binding site [chemical binding]; other site 373384011891 divalent metal binding site [ion binding]; other site 373384011892 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 373384011893 dimer interface [polypeptide binding]; other site 373384011894 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 373384011895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011897 arginine decarboxylase; Provisional; Region: PRK15029 373384011898 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 373384011899 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 373384011900 homodimer interface [polypeptide binding]; other site 373384011901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384011902 catalytic residue [active] 373384011903 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 373384011904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 373384011905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384011906 arginine:agmatin antiporter; Provisional; Region: PRK10644 373384011907 putative metal dependent hydrolase; Provisional; Region: PRK11598 373384011908 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 373384011909 Sulfatase; Region: Sulfatase; pfam00884 373384011910 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 373384011911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384011912 active site 373384011913 phosphorylation site [posttranslational modification] 373384011914 intermolecular recognition site; other site 373384011915 dimerization interface [polypeptide binding]; other site 373384011916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384011917 DNA binding site [nucleotide binding] 373384011918 sensor protein BasS/PmrB; Provisional; Region: PRK10755 373384011919 HAMP domain; Region: HAMP; pfam00672 373384011920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384011921 dimer interface [polypeptide binding]; other site 373384011922 phosphorylation site [posttranslational modification] 373384011923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384011924 ATP binding site [chemical binding]; other site 373384011925 Mg2+ binding site [ion binding]; other site 373384011926 G-X-G motif; other site 373384011927 proline/glycine betaine transporter; Provisional; Region: PRK10642 373384011928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384011929 putative substrate translocation pore; other site 373384011930 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 373384011931 YjcZ-like protein; Region: YjcZ; pfam13990 373384011932 hypothetical protein; Provisional; Region: PRK09866 373384011933 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 373384011934 G1 box; other site 373384011935 GTP/Mg2+ binding site [chemical binding]; other site 373384011936 G2 box; other site 373384011937 Switch I region; other site 373384011938 G3 box; other site 373384011939 Switch II region; other site 373384011940 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 373384011941 G2 box; other site 373384011942 Switch I region; other site 373384011943 G3 box; other site 373384011944 Switch II region; other site 373384011945 G4 box; other site 373384011946 G5 box; other site 373384011947 hypothetical protein; Provisional; Region: PRK10220 373384011948 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 373384011949 PhnA protein; Region: PhnA; pfam03831 373384011950 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 373384011951 dimer interface [polypeptide binding]; other site 373384011952 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 373384011953 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 373384011954 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 373384011955 Walker A/P-loop; other site 373384011956 ATP binding site [chemical binding]; other site 373384011957 Q-loop/lid; other site 373384011958 ABC transporter signature motif; other site 373384011959 Walker B; other site 373384011960 D-loop; other site 373384011961 H-loop/switch region; other site 373384011962 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 373384011963 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 373384011964 substrate binding pocket [chemical binding]; other site 373384011965 membrane-bound complex binding site; other site 373384011966 hinge residues; other site 373384011967 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 373384011968 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384011969 multidrug resistance protein MdtN; Provisional; Region: PRK10476 373384011970 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 373384011971 HlyD family secretion protein; Region: HlyD_3; pfam13437 373384011972 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 373384011973 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 373384011974 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 373384011975 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 373384011976 Sel1-like repeats; Region: SEL1; smart00671 373384011977 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 373384011978 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 373384011979 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 373384011980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 373384011981 binding surface 373384011982 TPR motif; other site 373384011983 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 373384011984 heme lyase subunit NrfE; Provisional; Region: PRK10369 373384011985 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 373384011986 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 373384011987 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 373384011988 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 373384011989 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 373384011990 acetyl-CoA synthetase; Provisional; Region: PRK00174 373384011991 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 373384011992 active site 373384011993 CoA binding site [chemical binding]; other site 373384011994 acyl-activating enzyme (AAE) consensus motif; other site 373384011995 AMP binding site [chemical binding]; other site 373384011996 acetate binding site [chemical binding]; other site 373384011997 Predicted membrane protein [Function unknown]; Region: COG3162 373384011998 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 373384011999 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 373384012000 Na binding site [ion binding]; other site 373384012001 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012002 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 373384012003 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 373384012004 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 373384012005 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 373384012006 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 373384012007 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 373384012008 DNA binding residues [nucleotide binding] 373384012009 dimer interface [polypeptide binding]; other site 373384012010 [2Fe-2S] cluster binding site [ion binding]; other site 373384012011 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 373384012012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384012013 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 373384012014 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 373384012015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 373384012016 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012017 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 373384012018 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 373384012019 dimer interface [polypeptide binding]; other site 373384012020 ssDNA binding site [nucleotide binding]; other site 373384012021 tetramer (dimer of dimers) interface [polypeptide binding]; other site 373384012022 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 373384012023 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 373384012024 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 373384012025 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 373384012026 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 373384012027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 373384012028 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 373384012029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384012030 active site 373384012031 motif I; other site 373384012032 motif II; other site 373384012033 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 373384012034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 373384012035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 373384012036 homodimer interface [polypeptide binding]; other site 373384012037 catalytic residue [active] 373384012038 alanine racemase; Reviewed; Region: alr; PRK00053 373384012039 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 373384012040 active site 373384012041 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 373384012042 substrate binding site [chemical binding]; other site 373384012043 catalytic residues [active] 373384012044 dimer interface [polypeptide binding]; other site 373384012045 replicative DNA helicase; Provisional; Region: PRK08006 373384012046 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 373384012047 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 373384012048 Walker A motif; other site 373384012049 ATP binding site [chemical binding]; other site 373384012050 Walker B motif; other site 373384012051 DNA binding loops [nucleotide binding] 373384012052 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 373384012053 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 373384012054 NADP binding site [chemical binding]; other site 373384012055 dimer interface [polypeptide binding]; other site 373384012056 phage shock protein G; Reviewed; Region: pspG; PRK09459 373384012057 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 373384012058 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 373384012059 FMN binding site [chemical binding]; other site 373384012060 active site 373384012061 catalytic residues [active] 373384012062 substrate binding site [chemical binding]; other site 373384012063 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 373384012064 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 373384012065 metal binding site 2 [ion binding]; metal-binding site 373384012066 putative DNA binding helix; other site 373384012067 metal binding site 1 [ion binding]; metal-binding site 373384012068 dimer interface [polypeptide binding]; other site 373384012069 structural Zn2+ binding site [ion binding]; other site 373384012070 hypothetical protein; Provisional; Region: PRK10428 373384012071 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 373384012072 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 373384012073 LexA repressor; Validated; Region: PRK00215 373384012074 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 373384012075 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 373384012076 Catalytic site [active] 373384012077 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 373384012078 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 373384012079 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 373384012080 putative acyl-acceptor binding pocket; other site 373384012081 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 373384012082 UbiA prenyltransferase family; Region: UbiA; pfam01040 373384012083 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 373384012084 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012085 maltose regulon periplasmic protein; Provisional; Region: PRK10564 373384012086 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 373384012087 trimer interface; other site 373384012088 sugar binding site [chemical binding]; other site 373384012089 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 373384012090 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 373384012091 Walker A/P-loop; other site 373384012092 ATP binding site [chemical binding]; other site 373384012093 Q-loop/lid; other site 373384012094 ABC transporter signature motif; other site 373384012095 Walker B; other site 373384012096 D-loop; other site 373384012097 H-loop/switch region; other site 373384012098 TOBE domain; Region: TOBE_2; pfam08402 373384012099 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 373384012100 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 373384012101 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 373384012102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384012103 dimer interface [polypeptide binding]; other site 373384012104 conserved gate region; other site 373384012105 putative PBP binding loops; other site 373384012106 ABC-ATPase subunit interface; other site 373384012107 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 373384012108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 373384012109 dimer interface [polypeptide binding]; other site 373384012110 conserved gate region; other site 373384012111 putative PBP binding loops; other site 373384012112 ABC-ATPase subunit interface; other site 373384012113 Predicted membrane protein [Function unknown]; Region: COG3223 373384012114 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 373384012115 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 373384012116 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 373384012117 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 373384012118 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 373384012119 active site 373384012120 dimer interface [polypeptide binding]; other site 373384012121 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 373384012122 dimer interface [polypeptide binding]; other site 373384012123 active site 373384012124 aspartate kinase III; Validated; Region: PRK09084 373384012125 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 373384012126 nucleotide binding site [chemical binding]; other site 373384012127 substrate binding site [chemical binding]; other site 373384012128 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 373384012129 lysine allosteric regulatory site; other site 373384012130 dimer interface [polypeptide binding]; other site 373384012131 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 373384012132 dimer interface [polypeptide binding]; other site 373384012133 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 373384012134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384012135 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 373384012136 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 373384012137 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 373384012138 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 373384012139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 373384012140 Homeodomain-like domain; Region: HTH_23; pfam13384 373384012141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384012142 Transposase; Region: HTH_Tnp_1; pfam01527 373384012143 IS2 repressor TnpA; Reviewed; Region: PRK09413 373384012144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384012145 IS2 transposase TnpB; Reviewed; Region: PRK09409 373384012146 HTH-like domain; Region: HTH_21; pfam13276 373384012147 Integrase core domain; Region: rve; pfam00665 373384012148 Integrase core domain; Region: rve_3; pfam13683 373384012149 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 373384012150 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 373384012151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 373384012152 Nucleoside recognition; Region: Gate; pfam07670 373384012153 hypothetical protein; Provisional; Region: PRK10519 373384012154 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 373384012155 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 373384012156 dimer interface [polypeptide binding]; other site 373384012157 active site 373384012158 cell density-dependent motility repressor; Provisional; Region: PRK10082 373384012159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 373384012160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 373384012161 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 373384012162 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 373384012163 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 373384012164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384012165 DNA-binding site [nucleotide binding]; DNA binding site 373384012166 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 373384012167 D-mannonate oxidoreductase; Provisional; Region: PRK15037 373384012168 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 373384012169 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 373384012170 mannonate dehydratase; Region: uxuA; TIGR00695 373384012171 mannonate dehydratase; Provisional; Region: PRK03906 373384012172 fructuronate transporter; Provisional; Region: PRK10034 373384012173 gluconate transporter; Region: gntP; TIGR00791 373384012174 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 373384012175 mannosyl binding site [chemical binding]; other site 373384012176 Fimbrial protein; Region: Fimbrial; pfam00419 373384012177 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 373384012178 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 373384012179 outer membrane usher protein; Provisional; Region: PRK15193 373384012180 PapC N-terminal domain; Region: PapC_N; pfam13954 373384012181 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 373384012182 PapC C-terminal domain; Region: PapC_C; pfam13953 373384012183 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 373384012184 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 373384012185 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 373384012186 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012187 Fimbrial protein; Region: Fimbrial; cl01416 373384012188 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 373384012189 Int/Topo IB signature motif; other site 373384012190 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 373384012191 active site 373384012192 Int/Topo IB signature motif; other site 373384012193 DNA binding site [nucleotide binding] 373384012194 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 373384012195 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 373384012196 Kelch motif; Region: Kelch_1; pfam01344 373384012197 Domain of unknown function (DUF303); Region: DUF303; pfam03629 373384012198 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012199 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384012200 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 373384012201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384012202 Transposase; Region: HTH_Tnp_1; pfam01527 373384012203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384012204 Transposase; Region: HTH_Tnp_1; pfam01527 373384012205 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012206 integrase; Provisional; Region: PRK09692 373384012207 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 373384012208 active site 373384012209 Int/Topo IB signature motif; other site 373384012210 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 373384012211 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 373384012212 putative NAD(P) binding site [chemical binding]; other site 373384012213 putative substrate binding site [chemical binding]; other site 373384012214 catalytic Zn binding site [ion binding]; other site 373384012215 structural Zn binding site [ion binding]; other site 373384012216 dimer interface [polypeptide binding]; other site 373384012217 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 373384012218 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 373384012219 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 373384012220 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 373384012221 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 373384012222 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 373384012223 multifunctional aminopeptidase A; Provisional; Region: PRK00913 373384012224 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 373384012225 interface (dimer of trimers) [polypeptide binding]; other site 373384012226 Substrate-binding/catalytic site; other site 373384012227 Zn-binding sites [ion binding]; other site 373384012228 DNA polymerase III subunit chi; Validated; Region: PRK05728 373384012229 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 373384012230 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 373384012231 HIGH motif; other site 373384012232 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 373384012233 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 373384012234 active site 373384012235 KMSKS motif; other site 373384012236 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 373384012237 tRNA binding surface [nucleotide binding]; other site 373384012238 anticodon binding site; other site 373384012239 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 373384012240 Predicted membrane protein [Function unknown]; Region: COG4269 373384012241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384012242 Coenzyme A binding pocket [chemical binding]; other site 373384012243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 373384012244 RNase E inhibitor protein; Provisional; Region: PRK11191 373384012245 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 373384012246 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 373384012247 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 373384012248 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012249 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 373384012250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373384012251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384012252 oxidoreductase; Provisional; Region: PRK12742 373384012253 classical (c) SDRs; Region: SDR_c; cd05233 373384012254 NAD(P) binding site [chemical binding]; other site 373384012255 active site 373384012256 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 373384012257 homotrimer interaction site [polypeptide binding]; other site 373384012258 putative active site [active] 373384012259 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 373384012260 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 373384012261 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 373384012262 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 373384012263 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 373384012264 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 373384012265 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 373384012266 homotrimer interaction site [polypeptide binding]; other site 373384012267 putative active site [active] 373384012268 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 373384012269 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 373384012270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 373384012271 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 373384012272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384012273 motif II; other site 373384012274 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 373384012275 trehalose repressor; Provisional; Region: treR; PRK09492 373384012276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 373384012277 DNA binding site [nucleotide binding] 373384012278 domain linker motif; other site 373384012279 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 373384012280 dimerization interface [polypeptide binding]; other site 373384012281 ligand binding site [chemical binding]; other site 373384012282 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 373384012283 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 373384012284 Ca binding site [ion binding]; other site 373384012285 active site 373384012286 catalytic site [active] 373384012287 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 373384012288 ATP cone domain; Region: ATP-cone; pfam03477 373384012289 Class III ribonucleotide reductase; Region: RNR_III; cd01675 373384012290 effector binding site; other site 373384012291 active site 373384012292 Zn binding site [ion binding]; other site 373384012293 glycine loop; other site 373384012294 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 373384012295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384012296 FeS/SAM binding site; other site 373384012297 cytochrome b562; Provisional; Region: PRK15058 373384012298 peptidase PmbA; Provisional; Region: PRK11040 373384012299 hypothetical protein; Provisional; Region: PRK05255 373384012300 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 373384012301 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 373384012302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 373384012303 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 373384012304 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 373384012305 AMP binding site [chemical binding]; other site 373384012306 metal binding site [ion binding]; metal-binding site 373384012307 active site 373384012308 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 373384012309 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 373384012310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 373384012311 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384012312 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384012313 TM-ABC transporter signature motif; other site 373384012314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 373384012315 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 373384012316 TM-ABC transporter signature motif; other site 373384012317 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 373384012318 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 373384012319 Walker A/P-loop; other site 373384012320 ATP binding site [chemical binding]; other site 373384012321 Q-loop/lid; other site 373384012322 ABC transporter signature motif; other site 373384012323 Walker B; other site 373384012324 D-loop; other site 373384012325 H-loop/switch region; other site 373384012326 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 373384012327 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 373384012328 dimer interface [polypeptide binding]; other site 373384012329 substrate binding site [chemical binding]; other site 373384012330 metal binding sites [ion binding]; metal-binding site 373384012331 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 373384012332 putative active site pocket [active] 373384012333 dimerization interface [polypeptide binding]; other site 373384012334 putative catalytic residue [active] 373384012335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 373384012336 Family of unknown function (DUF490); Region: DUF490; pfam04357 373384012337 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 373384012338 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 373384012339 Surface antigen; Region: Bac_surface_Ag; pfam01103 373384012340 methionine sulfoxide reductase A; Provisional; Region: PRK00058 373384012341 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 373384012342 Domain of unknown function DUF21; Region: DUF21; pfam01595 373384012343 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 373384012344 Transporter associated domain; Region: CorC_HlyC; smart01091 373384012345 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 373384012346 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 373384012347 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 373384012348 active site 373384012349 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 373384012350 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 373384012351 active site 373384012352 metal binding site [ion binding]; metal-binding site 373384012353 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 373384012354 Predicted transcriptional regulators [Transcription]; Region: COG1733 373384012355 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 373384012356 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 373384012357 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 373384012358 NADP binding site [chemical binding]; other site 373384012359 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 373384012360 EamA-like transporter family; Region: EamA; pfam00892 373384012361 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 373384012362 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 373384012363 Hemerythrin-like domain; Region: Hr-like; cd12108 373384012364 Fe binding site [ion binding]; other site 373384012365 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 373384012366 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 373384012367 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 373384012368 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 373384012369 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 373384012370 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 373384012371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 373384012372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384012373 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 373384012374 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 373384012375 putative NAD(P) binding site [chemical binding]; other site 373384012376 active site 373384012377 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 373384012378 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012379 putative transposase OrfB; Reviewed; Region: PHA02517 373384012380 Integrase core domain; Region: rve; pfam00665 373384012381 Integrase core domain; Region: rve_3; pfam13683 373384012382 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 373384012383 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012384 putative transcriptional regulator; Provisional; Region: PRK11640 373384012385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 373384012386 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 373384012387 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 373384012388 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 373384012389 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 373384012390 DsbD alpha interface [polypeptide binding]; other site 373384012391 catalytic residues [active] 373384012392 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 373384012393 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 373384012394 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 373384012395 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 373384012396 Aspartase; Region: Aspartase; cd01357 373384012397 active sites [active] 373384012398 tetramer interface [polypeptide binding]; other site 373384012399 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 373384012400 putative transporter; Provisional; Region: PRK11021 373384012401 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 373384012402 oligomerisation interface [polypeptide binding]; other site 373384012403 mobile loop; other site 373384012404 roof hairpin; other site 373384012405 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 373384012406 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 373384012407 ring oligomerisation interface [polypeptide binding]; other site 373384012408 ATP/Mg binding site [chemical binding]; other site 373384012409 stacking interactions; other site 373384012410 hinge regions; other site 373384012411 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 373384012412 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012413 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 373384012414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384012415 FeS/SAM binding site; other site 373384012416 elongation factor P; Validated; Region: PRK00529 373384012417 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 373384012418 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 373384012419 RNA binding site [nucleotide binding]; other site 373384012420 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 373384012421 RNA binding site [nucleotide binding]; other site 373384012422 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 373384012423 multidrug efflux system protein; Provisional; Region: PRK11431 373384012424 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 373384012425 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 373384012426 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 373384012427 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 373384012428 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 373384012429 Iron-sulfur protein interface; other site 373384012430 proximal quinone binding site [chemical binding]; other site 373384012431 C-subunit interface; other site 373384012432 distal quinone binding site; other site 373384012433 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 373384012434 D-subunit interface [polypeptide binding]; other site 373384012435 Iron-sulfur protein interface; other site 373384012436 proximal quinone binding site [chemical binding]; other site 373384012437 distal quinone binding site [chemical binding]; other site 373384012438 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 373384012439 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 373384012440 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 373384012441 L-aspartate oxidase; Provisional; Region: PRK06175 373384012442 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 373384012443 poxB regulator PoxA; Provisional; Region: PRK09350 373384012444 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 373384012445 motif 1; other site 373384012446 dimer interface [polypeptide binding]; other site 373384012447 active site 373384012448 motif 2; other site 373384012449 motif 3; other site 373384012450 putative mechanosensitive channel protein; Provisional; Region: PRK10929 373384012451 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 373384012452 DNA-binding site [nucleotide binding]; DNA binding site 373384012453 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 373384012454 Mechanosensitive ion channel; Region: MS_channel; pfam00924 373384012455 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 373384012456 GTPase RsgA; Reviewed; Region: PRK12288 373384012457 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 373384012458 RNA binding site [nucleotide binding]; other site 373384012459 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 373384012460 GTPase/Zn-binding domain interface [polypeptide binding]; other site 373384012461 GTP/Mg2+ binding site [chemical binding]; other site 373384012462 G4 box; other site 373384012463 G5 box; other site 373384012464 G1 box; other site 373384012465 Switch I region; other site 373384012466 G2 box; other site 373384012467 G3 box; other site 373384012468 Switch II region; other site 373384012469 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 373384012470 catalytic site [active] 373384012471 putative active site [active] 373384012472 putative substrate binding site [chemical binding]; other site 373384012473 dimer interface [polypeptide binding]; other site 373384012474 epoxyqueuosine reductase; Region: TIGR00276 373384012475 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 373384012476 putative carbohydrate kinase; Provisional; Region: PRK10565 373384012477 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 373384012478 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 373384012479 putative substrate binding site [chemical binding]; other site 373384012480 putative ATP binding site [chemical binding]; other site 373384012481 ADP-binding protein; Provisional; Region: PRK10646 373384012482 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 373384012483 AMIN domain; Region: AMIN; pfam11741 373384012484 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 373384012485 active site 373384012486 metal binding site [ion binding]; metal-binding site 373384012487 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 373384012488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384012489 ATP binding site [chemical binding]; other site 373384012490 Mg2+ binding site [ion binding]; other site 373384012491 G-X-G motif; other site 373384012492 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 373384012493 ATP binding site [chemical binding]; other site 373384012494 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 373384012495 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 373384012496 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 373384012497 bacterial Hfq-like; Region: Hfq; cd01716 373384012498 hexamer interface [polypeptide binding]; other site 373384012499 Sm1 motif; other site 373384012500 RNA binding site [nucleotide binding]; other site 373384012501 Sm2 motif; other site 373384012502 GTPase HflX; Provisional; Region: PRK11058 373384012503 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 373384012504 HflX GTPase family; Region: HflX; cd01878 373384012505 G1 box; other site 373384012506 GTP/Mg2+ binding site [chemical binding]; other site 373384012507 Switch I region; other site 373384012508 G2 box; other site 373384012509 G3 box; other site 373384012510 Switch II region; other site 373384012511 G4 box; other site 373384012512 G5 box; other site 373384012513 FtsH protease regulator HflK; Provisional; Region: PRK10930 373384012514 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 373384012515 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 373384012516 FtsH protease regulator HflC; Provisional; Region: PRK11029 373384012517 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 373384012518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 373384012519 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 373384012520 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 373384012521 GDP-binding site [chemical binding]; other site 373384012522 ACT binding site; other site 373384012523 IMP binding site; other site 373384012524 Predicted transcriptional regulator [Transcription]; Region: COG1959 373384012525 transcriptional repressor NsrR; Provisional; Region: PRK11014 373384012526 exoribonuclease R; Provisional; Region: PRK11642 373384012527 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 373384012528 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 373384012529 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 373384012530 RNB domain; Region: RNB; pfam00773 373384012531 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 373384012532 RNA binding site [nucleotide binding]; other site 373384012533 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 373384012534 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 373384012535 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 373384012536 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012537 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 373384012538 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 373384012539 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 373384012540 FAD binding site [chemical binding]; other site 373384012541 substrate binding site [chemical binding]; other site 373384012542 catalytic residues [active] 373384012543 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 373384012544 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 373384012545 esterase; Provisional; Region: PRK10566 373384012546 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 373384012547 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 373384012548 transcriptional repressor UlaR; Provisional; Region: PRK13509 373384012549 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 373384012550 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 373384012551 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 373384012552 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 373384012553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 373384012554 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 373384012555 active site 373384012556 P-loop; other site 373384012557 phosphorylation site [posttranslational modification] 373384012558 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 373384012559 active site 373384012560 phosphorylation site [posttranslational modification] 373384012561 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 373384012562 active site 373384012563 dimer interface [polypeptide binding]; other site 373384012564 magnesium binding site [ion binding]; other site 373384012565 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 373384012566 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 373384012567 AP (apurinic/apyrimidinic) site pocket; other site 373384012568 DNA interaction; other site 373384012569 Metal-binding active site; metal-binding site 373384012570 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 373384012571 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 373384012572 intersubunit interface [polypeptide binding]; other site 373384012573 active site 373384012574 Zn2+ binding site [ion binding]; other site 373384012575 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 373384012576 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 373384012577 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 373384012578 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 373384012579 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 373384012580 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 373384012581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384012582 Transposase; Region: HTH_Tnp_1; pfam01527 373384012583 HTH-like domain; Region: HTH_21; pfam13276 373384012584 Integrase core domain; Region: rve; pfam00665 373384012585 HTH-like domain; Region: HTH_21; pfam13276 373384012586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 373384012587 Integrase core domain; Region: rve; pfam00665 373384012588 Integrase core domain; Region: rve_3; pfam13683 373384012589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 373384012590 Transposase; Region: HTH_Tnp_1; pfam01527 373384012591 Uncharacterized conserved protein [Function unknown]; Region: COG3586 373384012592 endoribonuclease SymE; Provisional; Region: PRK13605 373384012593 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 373384012594 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373384012595 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 373384012596 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 373384012597 HsdM N-terminal domain; Region: HsdM_N; pfam12161 373384012598 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 373384012599 Methyltransferase domain; Region: Methyltransf_26; pfam13659 373384012600 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 373384012601 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 373384012602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 373384012603 ATP binding site [chemical binding]; other site 373384012604 putative Mg++ binding site [ion binding]; other site 373384012605 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012606 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 373384012607 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 373384012608 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 373384012609 P-loop, Walker A motif; other site 373384012610 Base recognition motif; other site 373384012611 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 373384012612 Uncharacterized small protein [Function unknown]; Region: COG2879 373384012613 carbon starvation protein A; Provisional; Region: PRK15015 373384012614 Carbon starvation protein CstA; Region: CstA; pfam02554 373384012615 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 373384012616 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 373384012617 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 373384012618 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 373384012619 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 373384012620 Cupin domain; Region: Cupin_2; pfam07883 373384012621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384012622 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 373384012623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384012624 putative substrate translocation pore; other site 373384012625 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 373384012626 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 373384012627 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 373384012628 putative substrate binding pocket [chemical binding]; other site 373384012629 trimer interface [polypeptide binding]; other site 373384012630 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 373384012631 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 373384012632 putative active site [active] 373384012633 putative metal binding site [ion binding]; other site 373384012634 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 373384012635 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 373384012636 NAD binding site [chemical binding]; other site 373384012637 catalytic residues [active] 373384012638 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 373384012639 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 373384012640 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 373384012641 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 373384012642 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 373384012643 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 373384012644 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 373384012645 dimer interface [polypeptide binding]; other site 373384012646 ligand binding site [chemical binding]; other site 373384012647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384012648 dimerization interface [polypeptide binding]; other site 373384012649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 373384012650 dimer interface [polypeptide binding]; other site 373384012651 putative CheW interface [polypeptide binding]; other site 373384012652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 373384012653 D-galactonate transporter; Region: 2A0114; TIGR00893 373384012654 putative substrate translocation pore; other site 373384012655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 373384012656 DNA-binding site [nucleotide binding]; DNA binding site 373384012657 Transcriptional regulators [Transcription]; Region: GntR; COG1802 373384012658 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 373384012659 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 373384012660 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 373384012661 NAD(P) binding site [chemical binding]; other site 373384012662 phosphoglycerol transferase I; Provisional; Region: PRK03776 373384012663 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 373384012664 hypothetical protein; Provisional; Region: PRK11667 373384012665 DNA replication protein DnaC; Validated; Region: PRK07952 373384012666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 373384012667 Walker A motif; other site 373384012668 ATP binding site [chemical binding]; other site 373384012669 Walker B motif; other site 373384012670 primosomal protein DnaI; Provisional; Region: PRK02854 373384012671 hypothetical protein; Provisional; Region: PRK09917 373384012672 Uncharacterized conserved protein [Function unknown]; Region: COG2966 373384012673 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 373384012674 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 373384012675 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 373384012676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384012677 DNA binding residues [nucleotide binding] 373384012678 dimerization interface [polypeptide binding]; other site 373384012679 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 373384012680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 373384012681 DNA binding residues [nucleotide binding] 373384012682 dimerization interface [polypeptide binding]; other site 373384012683 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 373384012684 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 373384012685 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 373384012686 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 373384012687 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 373384012688 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 373384012689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 373384012690 S-adenosylmethionine binding site [chemical binding]; other site 373384012691 DNA polymerase III subunit psi; Validated; Region: PRK06856 373384012692 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 373384012693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 373384012694 Coenzyme A binding pocket [chemical binding]; other site 373384012695 dUMP phosphatase; Provisional; Region: PRK09449 373384012696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384012697 motif II; other site 373384012698 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 373384012699 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 373384012700 G1 box; other site 373384012701 putative GEF interaction site [polypeptide binding]; other site 373384012702 GTP/Mg2+ binding site [chemical binding]; other site 373384012703 Switch I region; other site 373384012704 G2 box; other site 373384012705 G3 box; other site 373384012706 Switch II region; other site 373384012707 G4 box; other site 373384012708 G5 box; other site 373384012709 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 373384012710 periplasmic protein; Provisional; Region: PRK10568 373384012711 BON domain; Region: BON; pfam04972 373384012712 BON domain; Region: BON; pfam04972 373384012713 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 373384012714 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 373384012715 active site 373384012716 nucleophile elbow; other site 373384012717 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 373384012718 active site 373384012719 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 373384012720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 373384012721 FeS/SAM binding site; other site 373384012722 hypothetical protein; Provisional; Region: PRK10977 373384012723 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 373384012724 intersubunit interface [polypeptide binding]; other site 373384012725 active site 373384012726 catalytic residue [active] 373384012727 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 373384012728 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 373384012729 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 373384012730 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 373384012731 phosphopentomutase; Provisional; Region: PRK05362 373384012732 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 373384012733 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 373384012734 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 373384012735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384012736 non-specific DNA binding site [nucleotide binding]; other site 373384012737 salt bridge; other site 373384012738 sequence-specific DNA binding site [nucleotide binding]; other site 373384012739 hypothetical protein; Provisional; Region: PRK11246 373384012740 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 373384012741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 373384012742 motif II; other site 373384012743 DNA repair protein RadA; Region: sms; TIGR00416 373384012744 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 373384012745 Walker A motif/ATP binding site; other site 373384012746 ATP binding site [chemical binding]; other site 373384012747 Walker B motif; other site 373384012748 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 373384012749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 373384012750 non-specific DNA binding site [nucleotide binding]; other site 373384012751 salt bridge; other site 373384012752 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 373384012753 sequence-specific DNA binding site [nucleotide binding]; other site 373384012754 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 373384012755 active site 373384012756 (T/H)XGH motif; other site 373384012757 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 373384012758 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 373384012759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 373384012760 Walker A/P-loop; other site 373384012761 ATP binding site [chemical binding]; other site 373384012762 Q-loop/lid; other site 373384012763 ABC transporter signature motif; other site 373384012764 Walker B; other site 373384012765 D-loop; other site 373384012766 H-loop/switch region; other site 373384012767 ABC transporter; Region: ABC_tran_2; pfam12848 373384012768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 373384012769 lytic murein transglycosylase; Provisional; Region: PRK11619 373384012770 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 373384012771 N-acetyl-D-glucosamine binding site [chemical binding]; other site 373384012772 catalytic residue [active] 373384012773 Trp operon repressor; Provisional; Region: PRK01381 373384012774 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 373384012775 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 373384012776 catalytic core [active] 373384012777 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 373384012778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 373384012779 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 373384012780 hypothetical protein; Provisional; Region: PRK10756 373384012781 CreA protein; Region: CreA; pfam05981 373384012782 DNA-binding response regulator CreB; Provisional; Region: PRK11083 373384012783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384012784 active site 373384012785 phosphorylation site [posttranslational modification] 373384012786 intermolecular recognition site; other site 373384012787 dimerization interface [polypeptide binding]; other site 373384012788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384012789 DNA binding site [nucleotide binding] 373384012790 sensory histidine kinase CreC; Provisional; Region: PRK11100 373384012791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 373384012792 dimerization interface [polypeptide binding]; other site 373384012793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 373384012794 dimer interface [polypeptide binding]; other site 373384012795 phosphorylation site [posttranslational modification] 373384012796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 373384012797 ATP binding site [chemical binding]; other site 373384012798 Mg2+ binding site [ion binding]; other site 373384012799 G-X-G motif; other site 373384012800 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 373384012801 two-component response regulator; Provisional; Region: PRK11173 373384012802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 373384012803 active site 373384012804 phosphorylation site [posttranslational modification] 373384012805 intermolecular recognition site; other site 373384012806 dimerization interface [polypeptide binding]; other site 373384012807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 373384012808 DNA binding site [nucleotide binding] 373384012809 putative RNA methyltransferase; Provisional; Region: PRK10433 373384012810 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050